92 - Fluid Biomarkers for Alzheimer's Disease Part 2: September 2020

Elyn is back with more on fluid biomarkers for Alzheimer’s Disease from September 2020 papers. Here, she covers new candidate biomarkers including panels of lipids, soluble TREM2, and methylation sites on known risk genes. She also dives into insight into APOE4 mechanisms revealed by biomarkers, the stark overlap between vascular dementia and Alzheimer’s disease, and much more. This is a long one, but definitely worth a listen!  

Sections in this episode:  

Lipids - 6 papers - 3:22  

Hormones/lipoproteins - 3 papers  - 13:05  

Metabolites - 4 papers - 17:31  

Inflammation - 6 papers - 24:24  

Other Protein Targets - 5 papers - 33:18  

Nucleic Acids - 3 papers - 40:20 

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Today's episode was scripted and hosted by Elyn Rowe, and reviewed and edited by Alexandra Pavel. Big thanks to Elyn Rowe and Jacques Ferreira for sorting all the papers published in September 2020 into themes for our episodes, and props to the team that works very hard behind the scenes to make all this possible. 

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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Elyn Rowe would like to acknowledge her support from the Alzheimer Society of Canada, through the Alzheimer Society Research Program. The Alzheimer Society is committed to knowledge dissemination as a key pillar in their mission to  promote the search for causes, treatments, and a cure for Alzheimer disease.

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with abstract summary and podcast editing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  

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Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"