98 - Cerebrovascular changes in Alzheimer's Disease Part 2: September 2020

In this episode, Elyn caps off the papers on Cerebrovascular Changes in AD from September 2020. There’s mounting evidence for a significant overlap between vascular disease and brain health, and Elyn dives into the newest papers exploring this relationship. Tune in to hear about how cerebral small vessel disease might be the mediator between arteriosclerosis and cognitive impairment, how APOE is related to microbleeds, and how ACE1 inhibitors might be relevant in AD!  

Sections in this episode:  

1:50 - Relationship between Cerebral Small Vessel Disease & AD  

11:40 - Cerebral Small Vessel Disease & AD Progression  

14:09 - GWAS on Micro-bleeds  

15:46 - Mechanistic animal studies 

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Today's episode was scripted and hosted by Elyn Rowe, and reviewed and edited by Alexandra Pavel. Big thanks to Elyn Rowe and Jacques Ferreira for sorting all the papers published in September into themes for our episodes, and props to the team that works very hard behind the scenes to make all this possible. 

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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Elyn Rowe would like to acknowledge her support from the Alzheimer Society of Canada, through the Alzheimer Society Research Program. The Alzheimer Society is committed to knowledge dissemination as a key pillar in their mission to  promote the search for causes, treatments, and a cure for Alzheimer disease.

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with abstract summary and podcast editing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"