It is proposed that the endocrine hormone melatonin may regulate after its synthesis and secretion from the pineal gland, the deacetylase acivity of Sirtuin1 to diminish the SASP repertoire of aging and may be linked to common morbidity of pathophysiology linked to COPD and generic Respiratory Distress Syndrome (RDS)presentation.
Papers of Record in this episode
Int J Mol Sci. 2019 Mar; 20(5): 1223.
Int. J. Mol. Sci. 2014, 15, 16848-16884
International Immunopharmacology Volume 62, September 2018, Pages 23-28