Adaptation to stress-such as the fear response obtains dopaminergic input to striatum and prefrontal cortex and is thought to signal unexpected events and facilitate a shift in attention to promote new learning within the contralateral primary somatosensory cortex (SI) which has been associated with the agentic categories of both the quality and quantity of thought event ontology. This process works in conjunction with the bilateral secondary somatosensory cortex (SII) process involved in executive decision making. Where stimulated, the primary sensory motor-neuronal process is integrated with novel extra-dimensional learning .
Recall that this fear stress response can lose functional valency upon immune-regulating, senescent secretory phenotypes.
In the aging brain, where CRF axon terminals are widely distributed, (including within catecholamine and serotonin nuclei) there are widespread cortical projections into the medial prefrontal cortex; linking executive functional responses to adverse stimuli.
Dr. Daniel J. Guerra
Authentic Biochemistry
Published 20 Jan 2021
Refs
Neuroimage. 2008 May 1;40(4):1765-71.
Biol Psychiatry. 2009 Sep 15; 66(6): 586–593.