LC axonal projections to the mPFC modulate a diversity of cognitive processes, including working memory, sustained attention, and flexible attention and under moderate rates of LC activity and NE release, high-affinity postsvnaptic α2 adrenergic receptors in the PFC are preferentially engaged and promote working memory However, with elevated LC firing and activation of lower affinity α1 adrenergic receptors, working memory is impaired while agentic focused attention becomes prominent so it seems that LC projections to the PFC modulate different cognitive processes in a context-sensitive manner.
his latter mechanism could correlate with the experienced rapid response such as in “fight or flee” decision making upon immediate threatening danger. The sensation perception recognition and response behaviour all works sequentially from these neuronal loci post encounter to the stimulus and as such fit well into Kantian epistemology which obtains that the individual is presented with a particular stimulus-sense data or “intuition” that is processed by the faculty of the understanding as a perception of danger in association with a concept-abstracted from previous experience. This representation is then acted upon and the neural network-already poised to respond sequentially follows suit and ultimately directs the motor cortex to act.
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