Big Data are increasingly being used for both research and clinical care. Despite the increase of machine learning applications in both these fields, there is minimal work being done specifically in pediatrics, which presents a unique environment compared to adult care. Dr. Judith Dexheimer discusses the role and impact of AI and ML in research with the electronic health records, explore unique aspects of conducting work in pediatrics with biomedical informatics, and examine what is being done now with ML and what the future might hold.