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Confessions of a Male Gynecologist

125: The Truth About Semaglutide

39 min • 24 april 2025

Semaglutide has become the weight management sensation of the decade, but what's the science behind the hype? In this episode, I break down how these GLP-1 agonists really work, why 85% of patients regain weight after stopping, and why I use them as just one tool in my comprehensive approach to metabolic health. From side effects to proper patient selection, get the unfiltered medical perspective you need before considering these medications.

Episode Highlights:

  • The meteoric rise of Ozempic, Wegovy and Rybelsus that's causing nationwide shortages
  • How semaglutide actually works in your brain and digestive system to reduce appetite
  • Why patients regain weight after stopping and the importance of lifestyle integration
  • Real talk about side effects - from common digestive issues to rarer complications
  • The critical shift needed in how medicine approaches obesity treatment
  • Important differences between FDA-approved formulations and compounded alternatives
  • My professional recommendations for patient selection and monitoring protocols
  • How H.E.R. University supports comprehensive metabolic health beyond medication

Episode Resources:

Dr. Shawn Tassone's Practice | https://www.drshawntassone.com

Dr. Shawn Tassone's Book | The Hormone Balance Bible

Dr. Shawn Tassone's Integrative Hormonal Mapping System | Hormone Archetype Quiz

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Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.

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