DiabetesBio

Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes. 

6:30 In the first interview segment, our hosts discuss an article titled “Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice.” They’re joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419. 

25:20 Our hosts discuss the latest Paper of the Month, entitled “An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target.” They’re joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497. 

38:55 In the special edition of “Sweet Talk,” our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They’re joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD,  professor at UT Southwestern Medical Center in Dallas, Texas. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the March 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2025 issue of Diabetes. 

3:20 In the first interview segment, our hosts discuss the Paper of the Month, “Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays.” They’re joined by Anne Gresch, PhD, a postdoctoral fellow at the University of Colorado’s Anschutz Medical Campus, and Prof. Dr. Martina Düfer, from the Department of Pharmacology at the University of Munster Pharmaceutical and Medicinal Chemistry in Munster, Germany. This article is available for free at doi.org/10.2337/db23-0870. 

22:40 Our hosts discuss an article from the February issue of Diabetes, entitled “Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes.” They’re joined by lead author Delnaz Roshandel, PhD, Senior Research Associate, and Andrew Paterson, MD, both of the Genetics and Genome Biology Program at the Hospital for Sick Children in Toronto, Canada. This article is available for free at doi.org/10.2337/db24-0340. 

36:20 In the special edition of “Sweet Talk,” our hosts welcome Jeffrey S Flier, MD, former Dean of Harvard Medical School and past recipient of the ADA’s Banting Medal, as well as Christopher Bang Newgard, PhD, leader in pancreatic islet biology and metabolic disease at Duke University School of Medicine and previous recipient of the ADA’s Outstanding Scientific Achievement Award. They discuss an article by Diabetes editor-in-chief, David A. D’Alessio, on the historic development of the insulin radioimmunoassay, available for free at doi.org/10.2337/dbi24-0055. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the February 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2025 issue of Diabetes. 

3:55 In the first interview segment, our hosts our joined by Francis C. Lynn, BSc PhD, Associate Professor in the Department of Surgery and School of Biomedical Engineering at the University of British Columbia in Vancouver. He is the corresponding author of the article “Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line.” The article is available for free at doi.org/10.2337/db24-0756. 

18:25 Darleen, Kevin, and Kirk speak with David C. Wraith, PhD, Emeritus Professor of Immunology, and Michael J. Price, PhD, a research fellow, both at the Institute of Immunology and Immunotherapy at the University of Birmingham in the UK. They discuss their article, “Pre-clinical development of a tolerogenic peptide from glutamate decarboxylase as a candidate for antigen-specific immunotherapy in type 1 diabetes,” available at doi.org/10.2337/db23-0996. 

35:50 In the latest edition of “Sweet Talk,” our hosts welcome Bret H. Goodpaster, PhD, Scientific Director and Senior Investigator at the AdventHealth Translational Research Institute for Metabolism and Diabetes in Orlando, FL, and Professor of Medicine at Johns Hopkins University. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes. 

2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature. 

3:35 In part one of this special Sweet Talk segment, our hosts are joined by Philipp Scherer, PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and Joel Elmquist, DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA’s Outstanding Scientific Achievement Award, and Scherer recently received the ADA’s Banting Medal. 

They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases. 

33:00 In part two, our hosts speak with Jonathan Flak, PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA’s Pathway to Stop Diabetes Award. He discusses his work on the brain’s role in glucose regulation, energy balance, and bodyweight control. 

His article, “Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes,” can be found in the January 2025 issue of Diabetes. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes. 

0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include: 

• Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445
• Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388
• Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172
• Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020
• Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827
• Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175

6:15 Darleen is joined by Lukas Stilgenbauer of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as Mariana Sadagurski, associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University.  They discuss their article “Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.” This article is available for free at doi.org/10.2337/db24-0110

33:45 Kirk and Kevin dive into the December issue’s Paper of the Month, “Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes.” They’re joined by lead author Max Petersen, an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at doi.org/10.2337/db24-0083.

47:20 Finally, this month’s edition of Sweet Talk focuses on work funded by the American Diabetes Association’s Pathway to Stop Diabetes initiative. Kathleen Alanna Page, Associate Professor of Medicine at the University of Southern California’s Keck School of Medicine, and Jasmin Alves, a postdoctoral research fellow with Page, stop by to discuss Page’s study, “Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes.” The article is available at doi.org/10.2337/dbi24-0012

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes. 

3:45 After a quick rundown of our hosts' Halloween plans, this month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 

5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article “Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior.” This article is available for free at doi.org/10.2337/db24-0207. 

27:05 Our hosts discuss the November issue’s Paper of the Month, “Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy.” They’re joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at doi.org/10.2337/db24-0107. 

50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month’s Sweet Talk segment features Dr. Giles Yeo, a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 

4:05 This month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 

5:15 Darleen and Kirk speak with Dr. Magnus Grøndahl, faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, “Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis.” This article is available for free at doi.org/10.2337/db24-0305. 

19:05 Our hosts discuss a featured article entitled “Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function.” They’re joined by the study’s lead author, Dr. Jessie Barra, and corresponding author—as well as Barra’s mentor—Dr. Holger Russ. This study is available at doi.org/10.2337/db24-0346. 

35:00 Finally, just in time for National Vision Awareness Month, a Sweet Talk segment first: a discussion on the important topic of diabetic retinopathy. Dr. Siddharth Sunilkumar and Dr. Michael Dennis discuss their Perspectives article, “REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes,” funded by the ADA Pathway to Stop Diabetes Initiator Award, which was given to Dr. Dennis in 2014. This article is freely accessible at doi.org/10.2337/dbi24-0013. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 

4:20: Darleen and Kirk are joined by Jose A. Ortiz and Hsun Teresa Ku, first and last authors of “Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0490. 

25:07: Kirk and Darleen talk to Adrian Vella, last author of “The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.” This article is also an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db24-0192. 

50:21: In this month’s Sweet Talk segment, Kevin chats with Matthew J. Webber, a 2019 Pathway to Stop Diabetes Accelerator Award winner, about his research on materials that can sense and respond to changing glucose. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to a very special episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care “On Air,” acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care “On Air”; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care “On Air,” DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer.

This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the “bench-to-bedside” spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.)  

Correction: •Dr. Carmella Evans-Molina is from the Indiana University School of Medicine •Dr. Lou Philipson is from the University of Chicago

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes. 

2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled “Glucose Transporters Are Key Components of the Human Glucostat.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508. 

27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of “Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676.

50:21: In this month’s Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent “Classics in Diabetes” feature, named “Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/dbi24-0025. The original “Classics” article is freely accessible at https://doi.org/10.2337/diab.42.11.1678. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the July 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2024 issue of Diabetes. 

4:31: Darleen and Kirk are joined by Dr. Jordan J. Wright, first author of the Paper of the Month, entitled “Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0009. 

17:23: Kirk and Darleen then chat with Dr. Lisa Smeehuijzen, first author of the article “Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0970.

20:26: In a very special Sweet Talk segment, Kevin is joined by cohosts Darleen and Kirk for an interview with Dr. Rury R. Holman, the winner of the 2024 Banting Medal for Scientific Achievement. More details about this award can be found at https://professional.diabetes.org/awards/banting-medal-scientific-achievement-award.     

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the June 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2024 issue of Diabetes. 

2:27: Darleen and Kirk are joined by Dr. Ralph A. DeFronzo, senior author of the article “Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects.” This article is freely accessible at https://doi.org/10.2337/db23-0457.

20:26: In this month’s Sweet Talk segment, Kevin and Kirk highlight this month’s Point-Counterpoint feature on whether a new model is needed on the regulation of β-cell KATP channels in glucose metabolism. First, they talk to Drs. Matthew J. Merrins and Richard G. Kibbey, authors of the Counterpoint, titled “Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!” This article is freely accessible at https://doi.org/10.2337/dbi23-0032. 

35:00: Kevin next is joined by Drs. Guy A. Rutter and Ian R. Sweet, authors of the Point article, titled “Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?” This article is freely accessible at https://doi.org/10.2337/dbi23-0031.   

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the May 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2024 issue of Diabetes. 

5:06: Darleen and Kirk are joined by Drs. Devi Kasinathan, Zheng Guo, and Dax Fu, authors the May Paper of the Month, “Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice.” This article can be freely accessed at https://doi.org/10.2337/db23-0568.

20:14: Next, Kirk and Darleen highlight one of the ADA’s membership engagement groups, the Women’s Interprofessional Network of the ADA (WIN ADA), by chatting with Drs. Jennifer Lee and Rebecca Scalzo, the current cochairs of WIN ADA. They discuss the history and growth of WIN ADA, which is a members-only network for female clinicians, scientists, educators, and other health professionals in diabetes. Learn more about WIN ADA, including how to join, at https://professional.diabetes.org/membership/win-ada.

36:45: For the Sweet Talk segment, Kevin is joined by Drs. Olga T. Gupta and Rana K. Gupta, authors of May’s “Classics in Diabetes” article. The classic article they focus on is 1985’s “The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913,” by Ohlson et al. Kevin and his guests discuss the evolving concepts of regional adiposity and diabetes and other chronic disorders. Their “Classics” article is freely available at https://doi.org/10.2337/dbi24-0021, and the 1985 classic by Ohlson et al. can be found at https://doi.org/10.2337/diab.34.10.1055.   

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the April 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2024 issue of Diabetes. 

2:55: To kick things off, Darleen and Kirk are joined by Dr. Sebastian Kalamajski (Lund University), senior author of “Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.” This article can be freely accessed at https://doi.org/10.2337/db23-0531.

15:16: Darleen and Kirk chat with Dr. Yuval Dor (The Hebrew University of Jerusalem), senior author of “DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets.” This study can be freely accessed at https://doi.org/10.2337/db23-0704.

42:50: Darleen introduces a very special guest for this month’s Sweet Talk, Dr. Carmella Evans-Molina. She is the director of the Center for Diabetes and Metabolic Diseases at Indiana University School of Medicine, and she was awarded the 2023 Outstanding Scientific Achievement Award by the American Diabetes Association. Darleen and Kevin raise many topics in this conversation with Dr. Evans-Molina, from her focus on the role of calcium in regulating insulin secretion to the importance of serendipity and collaboration in scientific research to her recent hobby of learning to play the piano. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the special Sweet Talk March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. Our host is Dr. Kevin Williams. 

 1:00 Sweet Talk, part 1. Kevin introduces the guests for the first part of Sweet Talk, Dr. Christopher Newgard from Duke University Medical Center and Dr. Louis Philipson from the University of Chicago School of Medicine. They are co-chairs of the American Diabetes Association’s Pathway to Stop Diabetes Mentor Advisory Group. The Pathway program seeks to identify and support exceptional young scientists in the field of diabetes research. Drs. Newgard and Philipson explain the history of the program, expand on the importance of mentorship for young scientists, and relate challenges faced by the program, from funding cuts to the COVID-19 pandemic. 

18:56 Sweet Talk, part 2. To wrap up the episode, Kevin brings in Dr. Céline E. Riera, recipient of a Pathway to Stop Diabetes initiator award in 2015. Dr. Riera is the author of a thought-provoking Perspective article in the March 2024 issue of Diabetes that is based on her award-winning research. This article can be freely accessed at https://doi.org/10.2337/db23-0706. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2024 issue of Diabetes. 

1:15 Before getting underway with this week’s interviews, Kirk gives a quick shout-out to March’s Paper of the Month: “High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans,” by Gray et al. Although they only mention it in passing, Kirk does offer a ringing endorsement: “It’s excellent work, and all things glucagon are good.” This article is freely available at https://doi.org/10.2337/db23-0201. 

 2:44 Darleen announces that the March DiabetesBio is actually two episodes. The first part features Darleen and Kirk interviewing authors of the feature articles of the month, and the second part is devoted to Sweet Talk with Kevin. In this special episode, Kevin delves into the ADA’s Pathway to Stop Diabetes initiative with two of the initiative’s key members and one of the initiative’s award-winning researchers. 

 4:30 Darleen and Kirk interview Mr. Harry B. Cutler and Dr. David E. James, first and last authors of “Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia.” They discuss the use of a dual tracer test and describe insights into tissue-specific insulin action. They also raise an interesting question: Could it be that the popular belief that peripheral insulin resistance leads to hyperinsulinemia is inaccurate? This article can be freely accessed at https://doi.org/10.2337/db23-0035. 

 27:50 Kirk and Darleen then host Dr. Lori Sussel, last author of “PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress.” Dr. Sussel and her group determined that β-cells lacking PTPN2 are more susceptible to inflammatory stress associated with T1D due to impaired glucose-stimulated insulin secretion, mitochondrial defects, and reduced glucose-induced metabolic flux, indicating a role for PTPN2 in maintaining metabolic fitness in β-cells. This article can be freely accessed at https://doi.org/10.2337/db23-0355. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the February 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2024 issue of Diabetes. 

2:25: To kick things off, Darleen and Kirk are joined by Dr. Satya Dash of University Health Network and the Banting & Best Diabetes Centre, University of Toronto. Dr. Dash is the senior author of “Erythritol as a Potential Causal Contributor to Cardiometabolic Disease: A Mendelian Randomization Study.” Do low-calorie sweeteners possibly contribute to cardiometabolic disease? Listen to hear about the results of Dr. Dash’s study. This article can be freely accessed at https://doi.org/10.2337/db23-0330. 

14:52: Next, the Big 10 is well represented when Darleen and Kirk meet with Drs. Jeffrey Hodgin (University of Michigan) and Alan Attie (University of Wisconsin) to discuss their fascinating collaboration on their “Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice.” Drs. Hodgin and Attie’s study can be freely accessed at https://doi.org/10.2337/db23-0444. 

36:51: Sweet talk! Kevin introduces the first installment of the journal’s “Classics in Diabetes” series. This new format brings timeless articles into the spotlight and showcases their value for today’s scientists. The first installment, “GPCR Promiscuity Reshapes Islet Physiology” (https://doi.org/10.2337/dbi23-0014), was co-authored by Diabetes Associate Editor Jonathan Campbell and Frans Schuit and appears in the September 2023 issue of the journal. This commentary explores the work of Dr. Schuit, its implications for the understanding of diabetes, and how it laid the foundation for a rethinking of a traditional role of glucagon. Here, in this enlightening discussion, Dr. Schuit takes us through the historical context that led to the hypothesis and conclusions of his January 1998 classic, “Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors” (https://doi.org/10.2337/diab.47.1.66), and Dr. Campbell explains how rediscovering the concepts and findings of Dr. Schuit’s work has informed his current research. Drs. Schuit and Campbell conclude the discussion by sharing their thoughts on glucagon research and diabetes treatment. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the premiere episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In each episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams will discuss the latest and greatest content in Diabetes. The team kicks off this first episode with some brief introductions before passing the mic to Diabetes editor-in-chief David D’Alessio (5:35), who shares his experiences as the editor of the journal and describes new initiatives involving the journal.  

15:35: In addition, Dave and the team discuss the legacy and contributions of Daniel Porte Jr. Dan passed away at the age of 91 in May 2023, and he is the subject of a “Profiles in Progress” remembrance by Steven Kahn et al. in the January 2024 issue of Diabetes: https://doi.org/10.2337/db23-0787.

20:42: Darleen and Kirk then interview Dr. Gregory Steinberg of McMaster University. Dr. Steinberg is the senior author of “Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.” This article, which can be freely accessed at https://doi.org/10.2337/db23-0495, is the editor-selected Paper of the Month for the January 2024 issue of Diabetes.

31:49: In the “Sweet Talk” segment, Darleen and Kirk wrap up the episode by reviewing several interesting articles in January 2024 issue of Diabetes. Studies highlighted in this segment include:

• M.W. Pataky et al. Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors. https://doi.org/10.2337/db23-0142
• K. Motomura et al. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. https://doi.org/10.2337/db23-0212 
• C Jiménez-Sánchez et al. Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release. https://doi.org/10.2337/db23-0205
• C.M. Cohrs et al. Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis. https://doi.org/10.2337/dbi20-0018

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening!