The Roles of Oxytocin and Vasopressin in the Autistic Phenotype

39 min • 24 juni 2024

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.

Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/

Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/

Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue

Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284

Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis

https://pubmed.ncbi.nlm.nih.gov/33400920/

Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/

(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives

(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)

(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic

(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light

(8:58) Magnocellular and Parvocellular