Per-oral endoscopic myotomy (POEM) is a specialized endoscopic procedure to treat motility disorders of the esophagus. But what’s the procedure’s specific use in treating achalasia and other esophageal dysmotilities? To help answer that key question, Dr. Peter Buch is joined by Dr. Michel Kahaleh, Professor of Medicine and Director of the Pancreas Program in the Department of Medicine at Robert Wood Johnson Medical School, to discuss which patients to consider for POEM and key limitations of the procedure that clinicians should be aware of.