Silvia Molino - Polyphenol Expert

Bienvenidos Ah, this is where no, sorry, I screwed it up. So I got really nervous. It's like the lights came on. Okay.

Remember, we're actually saying that Yeah.

Okay, there we go. Three. You ready? Oh, yeah. Okay. Three, two on bmnh Oh, god check project. Your soy, Eric. Esta Dr. Brown,

Dr. Brown Como estas Morgana, grassy asmita story super emotional o por el podcastone tenemos en invitado fantastical. gephi ancestors that podcast story.

Sylvia done this style of video.

Wait, wait, wait, wait, wait, guys, I can't speak English. Oh, okay.

Oh, thank goodness cuz I'm pretty sure that's all the Spanish Eric knew. And banyo I got that down too. So why don't we Why don't we start over and just take it from the top in English. Now that we know that our wonderful guest who lives in Spain to learn all about That's right. actually speaks English. Okay, probably should have figured that out. Before we started the podcast

guys. I'm gonna start all over. So welcome gut check project fans and KB MD health family. It's now episode number 49. I'm Eric. This is my awesome co host Dr. Kenneth Brown. And today we've got an incredible special guest that I tried. I you know, I can't I tried Spanish.

I tried. You did so Eric. Eric dusted off his eighth grade Spanish. He was trying to impress Silvia you know, I mean, we're both a little nervous because what what we have on the podcast today is super special. Everybody has heroes in their life and Silvia is my hero because she is a poly phenol expert. She's getting her doctorate in specifically the polyphenols that we use on Tron teal. So she knows more about it than anybody I've ever met. And I'm so excited and nervous that we actually tried to speak in her native her native language.

I'm just embarrassed that but there'll be a welcome to the show. Welcome to go check project. Thank you so much for making

videos.

She said y'all she's trying to

learn some Texas now first of all, Silvia get us up to speed you're living in Granada Spain. What is going on there? You You WhatsApp to me You guys got a little earthquake situation right?

Yeah, we were we were we were that weights. But now where? We stay better here. Fortunately, visitation is is better.

You said it so calm. When you just WhatsApp you're like, oh, things are good. Here. We're dealing with a lot of earthquakes. Thanks for asking. Tough in Spain.

We used to.

So this is this is super cool. Thank you so much for coming on the podcast. I have followed your work. Some of the work that you have done as the lead author I have used we've discussed it on multiple podcasts. If you've seen Episode 47 Episode 46 multiple other episodes, we always refer to the large stable polyphenols and how they get broken down by the microbiome and the purse that articles that always reference. This is the author of those articles. Sylvia Molino, who is I almost called you doctor but you're almost a doctor, right? almost almost.

Nice. Nice. Hey, so

why don't you tell us a bit about your background how you ended up there? What's going on? Everything Everything about Silvia Molino.

Okay, so I am a biologist. I got my master's degree in Italy. But I the my train sheep here in Granada, where we started working with embitter. And they're just in implementation. And I fell in love with this argument. And then in one Congress, I met Michaela Battaglia is the CEO of silica team, that Britain is a b2b company that produced what the word leader is producing tannins that are polyphenols, sure, and he got interested in my work. So we started collaborating and and then we had the idea to create a new project to investigate the application of tannins in humans. And so I just started with my PhD working on that, and I'm still working on that and we have continuing on that

Yeah, that's awesome. So when you when you first hopped into it, were polyphenol something that drew your interest in their immediate applications for for health or is it something that just kind of just happened over time? What was it that drew you into wanting to study about polyphenols?

Well, um, I ever I always have been interesting in polyphenols about more in general about nutraceutical okay, because I believe that we could treat some diseases or some dysfunction with natural product, because actually, we are using a lot of synthetic treatment, but they were discovered from studying nature. So sometimes I think that we could go back to the power of nature. And in this case, 10 is

absolutely Well honestly, the timing really couldn't be better and where we find ourselves not just in the United States, but obviously all the way around the world for us to find and escape from synthetic solutions to what otherwise are just natural problems. And if probably we were consuming more polythene hauls as a you know, for the entire earth we would be in better shape. Yeah.

Repeat that.

Eric was just saying that you're exactly right. We have always we have a we have felt that the consumption of polyphenols is what what we're lacking in the western American diet. If we had more polyphenols we would have better health.

Yeah, yeah, for sure. Yeah,

I was just gonna say you use the word nutraceutical, which is, which is interesting because we've, we've coined that term, but what does nutraceutical mean to you as a scientist?

Wow, it's a hard question for me and you're just starting over is a solution that could be assumed for from a person by person. Like it will be a part of the natural diet like it will be a tude. Okay, so something more natural.

Okay, so a functional food, nutraceutical interesting, a molecule that can have health benefits, but it's found in nature?

Yeah, exactly.

And so you through your research, you found that these beautiful molecules called polyphenols have hold all this potential to be bioactive and possibly a nutraceutical for humans. So, for anybody that has not heard this, can you explain in your words what a poly phenol is?

Well, polyphenols are molecules if we can find in a network, obviously, the name derives from the chemical structure and they are well known for the multiple by activities beneficial by activities. First of all, they are antioxidant, they are what non antioxidant. And this is a super important characteristic of them because they help us to counteract the action of the oxidative stress. The oxidative stress is a normal events that we have that happens in our bodies, and can lead to a lot a lot of diseases and a lot of problems.

So leading to like inflammation, is that kind of what you're talking about there with long exposures of oxidative stress?

Well, can you repeat, please?

Sure. Are you saying that oxidative stress leads to inflammation, like more inflammation around tissues? Is that what you're saying?

Yeah, for sure. Well, normally we our normal metabolism, I produce free radicals. Okay. And this normal normal process of power rally, but what happens if we produce a high amount of, of these free radicals, and it's normal to breathe in sometimes to produce a lot of free radicals. And the causes could be external factors, such as stress or bad diet, for example, we have some endogenous mechanisms of our body to counteract these production of oxidative stress done by the free radicals, but these are not sufficient and are not not the most of the times. So we need to intake somehow. From from external hub. And in this case, we have to take antioxidant. And antioxidant we can find, for example, polyphenols, other one on the oxygen, for example, our could be vitamin C, Vitamin E. But from our study, for example, we could discover that time knees, among other 43 years has exert a higher activity than this well known molecules, such as vitamin C. So we cou...