Infectious Disease Puscast

On episode #43 of the Infectious Disease Puscast, Sara reviews the infectious disease literature for the weeks of 11/22 – 12/06/23.

Host: Sara Dong

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• Treatment for first cytomegalovirus infection post-hematopoietic cell transplant (CID)
• Mortality among children aged

On episode #42 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/09 – 11/21/23.

Host: Daniel Griffin and Sara Dong

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• Progress toward measles elimination (CDC)
• Slaying the troll of transplantation (TID)
• Association between the neutrophil-to-lymphocyte ratio and adverse outcomes in children aged

On episode #41 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/26 - 11/08/23.

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Host: Daniel Griffin and Sara Dong

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• Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong (JID)
• Efficacy and safety of corticosteroid therapy for community-acquired pneumonia (CID)
• Hydrocortisone in severe community-acquired pneumonia (NEJM)
• Early oral antibiotic switch in Staphylococcus aureus bacteraemia (CID)
• Outbreak of invasive Group A Streptococcus in children (PIDS)
• Inhaled amikacin to prevent ventilator-associated pneumonia (NEJM)
• Assessing risk for complications in acute hematogenous osteomyelitis in children (JPIDS)
• Empirical antibiotic therapy in diabetic foot ulcer infection increases hospitalization(OFID)
• 2023 guideline on diagnosis and management of acute bacterial arthritis in pediatrics (JPIDS)
• Natural history of antibiotic-treated lower limb cellulitis (OFID)
• Missed opportunities for preventing congenital syphilis (CDC)
• Diverse clinical manifestations and challenges of mucormycosis (OFID)
• Malaria (The Lancet)
• Clinical characteristics and outcomes of Chagas disease (AJTMH) 
• Direct gloving vs hand hygiene before donning gloves in adherence to hospital infection control practices (JAMA)
• How I approach diarrhea in hematological transplant patients (TID)
• Innovating pediatric infectious diseases recruitment and training (JPIDS)

Music is by Ronald Jenkees

On episode #40 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/13 – 10/25/23.

Host: Daniel Griffin and Sara Dong

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• Sustained viral suppression with dolutegravir monotherapy over 192 weeks in patients starting combination antiretroviral therapy during primary HIV infection (CID)
• Dolutegravir monotherapy possibly boosted by highly active natural immunity (CID)
• Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet)
• Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis (JID)
• Adjunctive dexamethasone for tuberculous meningitis in HIV-positive adults (NEJM)
• Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection (JAMA)
• Acute kidney injury with empirical antibiotics for sepsis (JAMA)
• Mycobacterium abscessus outbreak related to contaminated water among  ventilator-dependent residents of a pediatric facility (CDC)
• Trial of Vancomycin and Cefazolin as surgical prophylaxis in arthroplasty (NEJM)
• Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients (CMI)
• Risk of hematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals (CMI)
• In vitro susceptibility patterns for slowly growing non-tuberculous mycobacteria (JAC)
• Real-world use of mold-active triazole prophylaxis in the prevention of invasive fungal diseases (OFID)
• Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 (INI)
• Real-time dermoscopy of numerous mites crawling on the crusted scabies (CMI)
• The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis (The Lancet)
• Decolonization in nursing homes to prevent infection and hospitalization (NEJM)
• Can chatbot artificial intelligence replace ID physicians in the management of bloodstream infections (CID)
• Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in ICUs (JAMA)
• FDA Approves PENBRAYATM for the prevention of the five most common serogroups causing meningococcal disease in adolescents (Pfizer)

Music is by Ronald Jenkees

On episode #39 of the Infectious Disease Puscast, recorded at IDWeek in Boston, Daniel and special host Priya Kodiyanplakkal review the infectious disease literature for the weeks of 9/27 – 10/12/23.

Host: Daniel Griffin and Priya Kodiyanplakkal

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• Survival from rabies in a young child from India (AJTMH)
• The perils of overly-sensitive viral load testing for persons living with HIV (OFID)
• Letermovir vs Valganciclovir for prophylaxis of Cytomegalovirus in high-risk kidney transplant recipients (JAMA)
• Frailty and survival in the 1918 influenza pandemic (PNAS)
• Adverse pregnancy outcomes among HIV-infected Women taking isoniazid preventive therapy during the first trimester (CID)
• Ceftobiprole for treatment of complicated Staphylococcus aureus bacteremia (NEJM)
• Real-world application of oral therapy for infective endocarditis (CID)
• Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections (The Lancet)
• Information delay of significant bloodstream isolates and patient mortality (CID)
• Critical appraisal beyond clinical guidelines for intra-abdominal candidiasis (CC)
• Update on outbreak of fungal meningitis among Americans who received epidural anesthesia at clinics in Mexico
• Increasing prevalence of artemisinin-resistant HRP2-negative malaria in Eritrea (NEJM)
• Gender differences in psychosocial determinants of hand hygiene among physicians (ICHE)

Music is by Ronald Jenkees

On episode #38 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 9/14 – 9/27/23.

Host: Daniel Griffin and Sara Dong

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• Features of Long COVID identified through immune profiling (Nature)
• Severity of influenza-associated hospitalizations by influenza type (The Lancet)
• Cefazolin for the treatment of CNS infections (CID)
• Rifampin based therapy for patients with Staphylococcus aureus native vertebral Osteomyelitis (CID)
• State of the management of infections caused by multidrug-resistant organisms (CID)
• Are contact precautions “essential” for the prevention of healthcare-associated methicillin-resistant Staphylococcus aureus? (CID)
• Impact of the sequential implementation of a pharmacy-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal-swab ordering policy and vancomycin 72-hour restriction protocol on standardized antibiotic administration ratio (ICHE)
• Update on outbreak of fungal meningitis among US residents who received epidural anesthesia at two clinics in Mexico (CID)
• Paratracheal abscess by plant fungus Chondrostereum purpureum (MMCR)
• Canadian Blood Services traceback investigation of a suspected case of transfusion-transmitted malaria (Transfusion)
• Strongyloides infection screening in transplant candidates (TID)
• The world of microbial odors (JID)

Music is by Ronald Jenkees

On episode #37 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 8/31 – 9/13/23.

Host: Daniel Griffin and Sara Dong

Click arrow to play Download Puscast 037 (22 MB .mp3, 31 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• Association between varicella zoster virus and dementia (NS)
• Safety, efficacy, and immunogenicity of V160 vaccine in cytomegalovirus-seronegative women (The Lancet)
• Microorganisms detected in intussusception cases and controls in children (OFID)
• Clinician testing and treatment thresholds for management of UTIs (OFID)
• Clinical outcomes and management of NAAT-positive/toxin-negative Clostridioides difficile infection (CID)
• Associations of standard care, intrathecal antibiotics, and antibiotic impregnated catheters with cerebrospinal fluid shunt infection (JPIDS)
• Advances in asynchronous telemedicine call for increased antibiotic surveillance (CID)
• Two artificial tears outbreak-associated cases of extensively drug-resistant Pseudomonas aeruginosa detected through whole genome surveillance (JID)
• Pre-XDR congenital TB in an extremely premature baby (CID)
• Emerging Roles of (1→3)-β-D-glucan in cerebrospinal fluid for detection and therapeutic monitoring of fungal diseases (CID)
• Outbreak of locally acquired mosquito-transmitted malaria (CDC)
• Complexity of infectious diseases compared to other cognitive medical subspecialties (OFID)
• Risk of opportunistic infections associated with long-term glucocorticoid therapies in adults (CID)

Music is by Ronald Jenkees

On episode #36 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 8/17 – 8/30/23.

Host: Daniel Griffin

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• Detection of rotavirus in respiratory specimens from children aged under 2 years hospitalized for acute gastroenteritis (JID)
• Risk of Bell’s palsy following SARS-CoV-2 infection (CMI)
• Evaluation and management of diabetes-related foot infections (CID)
• Impact of mandatory infectious disease specialist approval on Clostridioides difficile infection rates and testing appropriateness (CID)
• Role of cerebral imaging on diagnosis and management in patients with suspected infective endocarditis (CID)
• Identifying effective durations of antibiotic therapy for the treatment of carbapenem-resistant Enterobacterales bloodstream infections (CID)
• Impact on clinical outcome of follow-up blood cultures and risk factors for persistent bacteraemia (CMI)
• State-of-the-art review: Neurosyphilis (CID)
• Oritavancin compared to the standard of care for treatment of non-endovascular gram-positive bloodstream Infections (OFID)
• How to approach suppressive antibiotic therapy following debridement, antibiotics, and implant retention for prosthetic joint infection (CID)
• 2023 Duke-International Society for cardiovascular infectious diseases criteria for infective endocarditis (CID)
• Adjunctive diagnostic studies completed following detection of candidemia in children (JPIDS)
• Oral lipid nanocrystal amphotericin b for cryptococcal meningitis (CID)
• Efficacy of 23 commonly used liquid disinfectants against Candida auris (IC&HE)
• Burrow ink test for scabies (NEJM)
• Evolution of partial resistance to artemisinins in malaria parasites in Uganda (NEJM)
• Human neural larva migrans caused by Ophidascaris robertsi ascarid (EID)

Music is by Ronald Jenkees

On episode #35 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 8/3 – 8/16/23.

Host: Daniel Griffin

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• Powassan virus encephalitis: a tertiary center experience (CID)
• Diagnostic accuracy of hospital antibiograms in predicting the risk of antimicrobial resistance in Enterobacteriaceae isolates (CID)
• Timely diagnosis of incubating syphilis infections using Treponema pallidum (CID)
• Impact of rapid identification and stewardship intervention on coagulase-negative Staphylococcus bloodstream infection (OFID)
• Natural antibodies mediate protection against Acinetobacter baumannii respiratory infections (JID)
• Risk of misleading conclusions in observational studies of time-to-antibiotics and mortality in suspected sepsis (CID)
• Cryptococcal meningitis in young, immunocompetent patients (OFID)
• Experimental acquisition, maintenance, and transmission of methicillin-resistant Staphylococcus aureus (MRSA) (JID)
• Clinical characteristics and prognosis of pediatric Phthirus pubis coinfestation of the eyelashes and scalp hairs (AMJTMH)
• Prognostic significance of Lymphocyte Subpopulations for ICU-acquired Infections in sepsis patients (JHI)

Music is by Ronald Jenkees

On episode #34 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/20 – 8/2/23.

Host: Daniel Griffin

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• FDA approves first treatment for molluscum contagiosum (FDA)
• Identifying children likely to benefit from antibiotics for Acute Sinusitis (JAMA)
• Impact of metagenomic next-generation sequencing of plasma cell-free DNA testing in patients with suspected infectious diseases (OFID)
• Impact of infectious diseases consultation in patients with candidemia at a multisite healthcare system (OFID)
• Relapsing babesiosis with molecular evidence of resistance to certain antimicrobials commonly used to treat Babesia microti infections (OFID)
• Seroprevalence of Chagas disease among people of Latin American descent (AJTMH)
• Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults (The Lancet)
• The human blood fluke, Schistosoma mansoni, harbors bacteria throughout the parasite’s life cycle (JID)
• Health care provider knowledge regarding Alpha-gal syndrome (CDC)

Music is by Ronald Jenkees

On episode #33 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/6 – 7/19/23.

Host: Daniel Griffin

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• Early antiretroviral therapy not associated with higher cryptococcal Meningitis mortality in people with HIV in high-income countries (CID)
• Implementing a rapid Antiretroviral therapy program using starter packs for emergency department patients diagnosed with HIV infection (OFID)
• Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk Penicillin allergy (JAMA)
• Infectious diseases consultation associated with reduced mortality in gram-negative bacteremia (CID)
• Positive impact of [18F]FDG-PET/CT on mortality in patients with Staphylococcus aureus Bacteremia explained by immortal time bias (CID)
• Azithromycin for bacterial watery diarrhea (JID) 
• Periprosthetic joint infection: current clinical challenges (CID)
• Old World medieval Treponema pallidum complex treponematosis (JID)
• Clinical Impact of polymerase chain reaction–based Aspergillus and Azole resistance detection in invasive aspergillosis (CID)
• Superior accuracy of Aspergillus plasma cell-free DNA PCR over serum galactomannan for the diagnosis of invasive aspergillosis (CID)
• Tafenoquine co-administered with dihydroartemisinin–piperaquine for the radical cure of Plasmodium vivax malaria (The Lancet)
• Doubling of cyclosporiasis cases partially attributable to a salad kit (CDC)
• Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia (BMC)

Music is by Ronald Jenkees

On episode #32 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/21 – 7/4/23.

Hosts: Daniel Griffin and Sara Dong

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• Clinical characteristics and outcomes among travelers with severe dengue (AIM)
• Phase 3 randomized trial of Bulevirtide in chronic hepatitis D (NEJM)
• Increased peripheral inflammation associated with structural brain changes and reduced blood flow in virologically controlled people with HIV (JID)
• Sustained viral suppression with dolutegravir monotherapy over 192 weeks in HIV patients (CID)
• Side-by-side comparative study of the immunogenicity of the intramuscular and intradermal rabies post-exposure prophylaxis regimens in suspected RABV exposed individuals (CID)
• Reliability of admission procalcitonin testing for capturing bacteremia across the sepsis spectrum (CCM)
• Early discontinuation of antibiotics in patients admitted with clinically suspected serious infection but negative cultures (OFID)
• Short-course therapy for urinary tract infections in children (JAMA)
• Autochthonous Leprosy in the United States (NEJM)
• Management of pediatric pneumonia (CID)
• Added value of (1,3)-β-D-glucan for the diagnosis of Invasive candidiasis in ICU patients (Infection)
• Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles (PLOS Pathogens)
• Locally acquired malaria cases identified in the US (CDC)
• Nanoplasmonic amplification in microfluidics enables accelerated colorimetric quantification of nucleic acid biomarkers from pathogens (NN)

Music is by Ronald Jenkees

On episode #31 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/8 – 6/20/23.

Hosts: Daniel Griffin and Sara Dong

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• Relative effectiveness of the cell-based quadrivalent influenza vaccine in preventing cardiorespiratory hospitalizations (OFID)
• Evaluation of Oseltamivir used to prevent hospitalization in outpatients with influenza (JAMA)
• Pan-ebolavirus monoclonal antibody cocktail provides protection against Ebola and Sudan viruses (JID)
• Inappropriate antibiotic prescribing and its determinants among outpatient children in low-and middle-income countries (PLOS)
• IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections (IDSA)
• Evaluating antimicrobial duration for gram-negative bacteremia in patients with neutropenia (TID)
• Antibiotic myths for the ID clinician (CID)
• Dalbavancin for the treatment of acute bacterial skin and skin structure infection in patients with obesity or Diabetes (OFID)
• Global differences in the management of S. aureus bacteremia (CID)
• Clinical risk Scores to Predict Trimethoprim-Sulfamethoxazole, Fluoroquinolone, Nitrofurantoin, and Cephalosporin non-susceptibility among outpatient episodes of complicated UTI among adults (OFID)
• Continuous vs intermittent meropenem administration in critically ill patients with sepsis (JAMA)
• Current pyuria cutoffs promote inappropriate UTI diagnosis in older women (CID)
• Paenibacillus infection as a novel cause of sepsis in term neonates with high risk of sequelae in Uganda (CID)
• Antimicrobial for 7 or 14 Days for febrile urinary tract infection in men (CID)
• Candida auris‒associated hospitalizations (EID)
• Fatal invasive mold infections after transplantation of organs recovered from drowned donors (EID)

Music is by Ronald Jenkees

On episode #30 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/24 – 6/7/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Foodborne illness outbreaks at retail food establishments (CDC)
• Donor-derived fulminant herpes simplex virus hepatitis after liver transplantation (TID)
• High-dose influenza vaccine is associated with reduced mortality among older adults with breakthrough influenza (CID)
• Letermovir vs valganciclovir for prophylaxis of cytomegalovirus in high-risk kidney transplant recipients (JAMA)
• Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with pneumonia (CC)
• Safety of Streptococcus pyogenes vaccines (CID)
• Meningococcal ACWYX conjugate vaccine in 2 to 29 year olds (NEJM)
• Orthopaedic surgical management of pressure-ulcer related pelvic osteomyelitis (OFID)
• On culture and blood cultures (CMI)
• Benchmarking of outpatient pediatric antibiotic prescribing (JPIDS)
• Outbreak of suspected fungal meningitis in US patients who underwent surgical procedures under epidural anesthesia (CDC)
• Risk of systemic fungal infections after exposure to wildfires (The Lancet)
• Giardia duodenalis and dysentery in Iron Age Jerusalem (Parastiology)
• Community water fluoridation levels to promote effectiveness and safety in oral health (CDC)

Music is by Ronald Jenkees

On episode #29 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/11 – 5/23/23.

Hosts: Daniel Griffin and Sara Dong

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• Harmonie phase IIIb study trial results of nirsevimab against RSV lower respiratory tract infection hospitalization for infants (ESPID)
• Mogamulizumab for treatment of HTLV-1 associated Myelopathy/Tropical Spastic Paraparesis (IDSA)
• Revised protocol for secondary prevention of congenital cytomegalovirus infection with valaciclovir (IDSA)
• Increase in false positive fourth generation HIV tests in patients with COVID-19 (CID)
• Implementation of an antibiotic stewardship initiative in a large urgent care network (JAMA)
• Clindamycin + vancomycin versus linezolid for treatment of necrotizing soft tissue infection (OFID)
• Assessing empiric antimicrobial therapy with the dundee classification for skin and soft tissue infections (OFID)
• Combination of amoxicillin 3000mg and probenecid vs 1500mg amoxicillin monotherapy for treating syphilis in patients with HIV (CID)
• The sympathetic nervous system is necessary for development of CD4+ T cell memory following Staphylococcus aureus infection (JID)
• Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with infections caused by Acinetobacter baumannii-calcoaceticu complex (The Lancet)
• First reported US cases of tinea caused by Trichophyton indotineae (CDC)
• How to use direct microscopy for diagnosing fungal infections (CMI)
• Limited Cutaneous Leishmaniasis as Ulcerated Verrucous Plaque on leg (EID)
• Can Ivermectin kill Sarcoptes scabiei during the molting process? (PLOS)
• The Infectious Diseases Specialist, at risk of extinction (JID)
• Ticks harbor and excrete chronic wasting disease prions (NIH)

Music is by Ronald Jenkees

On episode #28 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/26 – 5/10/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Unprecedented outbreak of West Nile Virus (CDC)
• Approval of first RSV vaccine approved for individuals 60 years and older (FDA)
• FDA approves orally administered fecal microbiota product for the prevention of recurrence of C-difficile (FDA)
• Using thermal imaging to track cellulitis (OFID)
• Burden of Typhoid and Paratyphoid fever in India (NEJM)
• Early switch to oral antimicrobials in brain abscess (CMI)
• Considering vancomycin alternatives for pediatric methicillin-resistant Staphylococcus aureus bacteremia (JPIDS)
• Navigating treatment options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus complex infections (CID)
• 2023 Duke-ISCVID criteria for infective Endocarditis (CID)
• Molecular characterization of Candida auris outbreak isolates in Qatar from COVID-19 patients (CMI)
• Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi (JID)
• Impact of Sequestration on Artemisinin-Induced Parasite Clearance in Plasmodium falciparum Malaria (CID)
• Advances in artificial intelligence for infectious disease surveillance (NEJM)

Music is by Ronald Jenkees

On episode #27 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/13 – 4/25/23.

Hosts: Daniel Griffin and Sara Dong

Click arrow to play Download Puscast 027 (19 MB .mp3, 31 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• Prevalence, clinical severity, and seasonality of Adenovirus 40/41, Astrovirus, Sapovirus, and Rotavirus among children with moderate-to severe diarrhea (CID)
• Antibiotic-prescribing practices for management of childhood diarrhea in 3 sub-Saharan African countries (CID)
• Drivers of decline in diarrhea mortality (CID)
• Breastfeeding among people with HIV in North America (CID)
• Wearable sensor-based detection of Influenza in presymptomatic and asymptomatic individuals (JID)
• Emergence of erythromycin-resistant invasive group a Streptococcus (EID)
• Piperacillin-Tazobactam compared With Cefoxitin as antimicrobial prophylaxis for pancreatoduodenectomy (JAMA)
• VE303 for prevention of recurrent Clostridioides difficile infection (JAMA)
• Geographic patterns of antimicrobial susceptibilities for Bacteroides species worldwide (IJAA)
• Intravenous to oral antibiotic switch therapy among patients hospitalized with community-acquired pneumonia (CID)
• Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalized with suspected gastroenteritis (The Lancet)
• Treatment of pulmonary mucormycosis with adjunctive nebulized amphotericin B (Mycoses)
• Giardia detection and codetection with other enteric pathogens in children in the vaccine impact on diarrhea in Africa (CID)
• Feasibility of training community health workers to use smartphone-attached microscopy for point-of-care visualization of soil-transmitted helminths (AJTMH)
• Compassionate use of bacteriophages for failed persistent infections (OFID)

Music is by Ronald Jenkees

On episode #26 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/30 – 4/12/23.

Hosts: Daniel Griffin and Sara Dong

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• Fatal rabies infection with failure of post-exposure prophylaxis following a zoonotic exposure (CID)
• Bivalent perfusion F vaccine in pregnancy to prevent RSV in infants (NEJM)
• Adeno-associated virus type 2 in US children with severe hepatitis (Nature)
• Genomic investigations of unexplained hepatitis in children (Nature)
• Antiretroviral treatment of HIV/AIDS during pregnancy (JAMA)
• Rapid PCR for respiratory viruses reduces time to result and improves clinical care (JOI)
• Postexposure doxycycline to prevent bacterial sexually transmitted infection (NEJM)
• Survey on antimicrobial resistance genes of used probiotic bacteria (EURO)
• Structured immune work-up in healthy children with episode of severe bacterial infection (JID)
• Antibiotic prescribing in U.S. nursing homes (JID)
• Syndromic panel testing among patients with infectious diarrhea (OFID) 
• Early predictors of infected pancreatic necrosis in severe pancreatitis (DD)
• Management of nontuberculous mycobacteria in lung transplant cases (ERJ)
• Impact of extended-infusion piperacillin-tazobactam (Infectious Medicine)
• Camber Pharmaceuticals issues nationwide recall of atovaquone oral suspension due to potential Bacillus cereus contamination (FDA)
• Cluster of Blastomycosis among neighborhood residents (CDC)
• Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients (IJID)
• Hyponatremia predicts cryptococcal meningitis and mortality in HIV-Positive asymptomatic individuals with cryptococcal antigenemia (OFID)
• Investigation of donor-derived Strongyloides stercoralis infection in multiple solid organ transplant recipients (TID)
• Promising new malaria vaccine for kids approved in Ghana (AP)

Music is by Ronald Jenkees

On episode #25 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/23 – 3/29/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates (Nature)
• First evidence of locally acquired Dengue infection (CDC)
• Respiratory viral infections in recipients of cellular therapies (OFID)
• Evolving Japanese encephalitis situation in Australia (JTM)
• Attainment of target antibiotic levels by oral treatment of left-sided infective endocarditis (CID)
• Utility of PCR vs serology based testing in immunocompromised patients with Bartonella (OFID)
• Source-associated mobile genetic elements to identify zoonotic coli infections (OneHealth)
• The risk of urinary tract infection in vegetarians and non-vegetarians (Nature)
• Hydrocortisone in severe community acquired pneumonia (NEJM)
• Adjunctive dexamethasone treatment in adults with Listeria monocytogenes meningitis (The Lancet)
• Worsening spread of Candida auris in the United States (AIM)
• Origin, resistance, and spread of the emerging human fungal pathogen Candida auris (PLOS)
• Emergence of Candida auris (mBio)
• Invasive aspergillosis in liver transplant recipients (Transplant ID)
• Trends in reported babesiosis cases (CDC)
• PCR assay for diagnosis of tick-borne infections in children (OFID)
• Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum (PLOS)
• Emphasis of diversity, equity and inclusion on U.S Adult Infectious Disease Fellowship program websites (JID)

Music is by Ronald Jenkees

On episode #24 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/1 – 3/22/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Re-emergence of Parechovirus: 2017-2022 national trends of detection in CSF (OFID)
• Screening and testing for hepatitis B virus infection (CDC)
• Changing epidemiology of carbapenemases among carbapenem-Resistant Enterobacterales (OFID)
• Comparison of a short vs long-course antibiotic therapy for ventilator-associated pneumonia (eClinicalMedicine)
• The impact of timing of infectious disease consultation for Staphylococcus aureus bacteremia (CID)
• Intravenous doxycycline, azithromycin, or both for severe scrub typhus (NEJM)
• Cronobacter sakazakii infections in two infants linked to powdered infant formula and breast pump equipment (CDC)
• Piperacillin/tazobactam vs cefepime or carbapenems for cefoxitin-non-susceptible bacteraemia in immunocompromised patients (JAC)
• Positive impact of [18F) FDG-PET/CT on mortality in patients with Staphylococcus aureus bacteremia (CID)
• Association of antibody immunity with cryptococcal antigenemia and mortality in a South African cohort with advanced HIV (CID)
• Practical guide to antifungal susceptibility testing (JPIDS)
• Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID)
• Emergence and Persistence of Candida auris in Western New York with no epidemiologic links (OFID)

Music is by Ronald Jenkees

On episode #23 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/16 – 2/28/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Association between cytomegalovirus infection and tuberculosis disease (JID)
• In-depth virological and immunological characterization of HIV-1 cure after allogeneic hematopoietic stem cell transplantation (Nature)

• Algorithm-based Clostridioides difficile testing as a tool for antibiotic stewardship(CMI)

• Clinical utility of nasal surveillance swabs in ruling-out MRSA infections in children (JPIDS)
• Antimicrobial for 7 or 14 days for febrile UTI in men (CID)
• Treatment strategy for rifampin-susceptible TB (NEJM)
• Current pyuria cut-offs promote inappropriate UTI diagnosis in older women (CID)
• Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults (CID)
• Hospitalizations for unspecified mycoses and implications for fungal disease burden estimates (OFID)
• Invasive mold infections following Hurricane Harvey (OFID)
• Cryptococcal meningitis and clinical outcomes in persons with HIV (CID)
• Rapid range shifts in African Anopheles mosquitoes over the last century (Biology Letters)
• Neuroangiostrongyliasis: Rat lungworm invades Europe (ASTMH)
• Balamuthia mandrillaris encephalitis presenting as a symptomatic focal hypodensityin an immunocompromised patient (OFID)
• Low rates of antibiotics prescribed during telehealth primary-care visits persisted during COVID19 (ICHE)

Music is by Ronald Jenkees

On episode #22 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/2 – 2/15/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Influence of rapid influenza diagnostic testing on clinician decision-making for patients with acute respiratory infection (CID)
• Outbreak of extensively drug-resistant Pseudomonas aeruginosa (CDC)
• Epidemiology and clinical outcomes of non-HACEK gram-negative infective endocarditis (OFID)
• Azithromycin to prevent sepsis or death in women planning a vaginal birth (NEJM)
• Clinical significance of concomitant bacteruria in patients with Staphylococcus aureus bacteremia (EJCM)
• Health disparities in hemodialysis associated Staph aureus bloodstream infections (CDC)
• Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteremia (CMI)
• Genome-wide analysis of transposon mobility in the human fungal pathogen Cryptococcus deneoformans (PNAS)
• Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia (CID)
• Prevalence of Ocular Complications in candidemia (CID)
• Rapid and spontaneous post-partum clearance of Plasmodium falciparum (JID)
• Adoption and utilization of social media among adult and pediatric infectious diseases divisions and fellowship programs (OFID)
• Canine detection of chronic wasting disease in laboratory and field settings (Prion)

Music is by Ronald Jenkees

On episode #21 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/18/23 – 2/1/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• The impact of cold temperature in the pattern of influenza virus infection (OFID)
• Janssen to discontinue Phase 3 Mosaico HIV vaccine clinical trial (JNJ)
• Randomized trial of vaccines for Zaire Ebola virus disease (NEJM)
• PD-1 blockade and lenalidomide combination therapy for Epstein-Barr virus infection (CMI)
• Outcomes of Daptomycin plus Ceftaroline vs alternative therapy for persistent MRSA bacteremia (IJAA)
• Detection of a novel strain of multidrug-non-susceptible Neisseria gonorrhoeae (The Lancet)
• Impact of a device to reduce blood culture contamination and false-positive central-line bloodstream infections (ICHE)
• Addition of anaerobic coverage for treatment of biliary tract infections (JAC)
• High dose Cefepime vs Carbapenems for bacteremia caused by Enterobacterales(OFID)
• Assessing the diagnostic performance of IGRAs for Mycobacterium tuberculosis (CID)
• Infective endocarditis after transcatheter aortic valve replacement (JACC)
• Discordant clinical and microbiological outcomes are associated with late clinical relapse in clinical trials for complicated UTIs (CID)
• Real-world use of bezlotoxumab and fecal microbiota transplantation for the treatment of Cdiff (OFID)
• Blastomycosis in New England (OFID)
• Management of invasive candidiasis in hematopoietic cell transplant recipients (TCT)
• Short course of Antifungal therapy in patients with uncomplicated Candida Bloodstream infection (OFID)
• Parasites and childhood stunting (Cell)
• Comparing complication rates of midline catheter vs. PICC line (OFID)
• Novel prion strain as the cause of chronic wasting disease in a moose (EID)
• Agreement of respiratory viruses’ detection between nasopharyngeal swab and bronchoalveolar lavage in adults with pneumonia (CMI)

Music is by Ronald Jenkees

On episode #20 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/4/23 – 1/17/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Neuroinvasive West Nile infection in solid organ transplant recipients (TID)
• Clinical markers of post-Chikungunya chronic inflammatory joint disease (PLOSNTD)
• Cholera outbreak in Haiti (CDC)
• Legionella bononiensis isolated from a hotel water in Nothern Italy (MS)
• Contemporary pharmacotherapies for nontuberculosis mycobacterial infections (IDT)
• Defining the optimal duration of therapy for hospitalized patients with UTIs and Bacteremia (CID)
• Fidaxomicin to prevent recurrent Clostridioides difficile (JAC)
• Evaluating predictive value of resected proximal bone margins in Diabetic Foot Osteomyelitis(OFID)
• Postoperative inflammation and fever after elective aortic valve and aortic root replacement (OFID)
• Fungal nomenclature: managing change is the name of the game (OFID)
• Clinical microbiology laboratories should use nomenclature based on current taxonomy (JCM)
• Race and ethnicity: risk factors for fungal infections (PLOS)
• Mosquito net use in early childhood and survival to adulthood in Tanzania (NEJM)
• Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand (The Lancet)

Music is by Ronald Jenkees

On episode #19 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/22/22 – 1/3/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Burden of postinfectious symptoms after Acute Dengue (EID)
• Maribavir for CMV treatment in the real world (OFID)
• 24-Week all-oral regimen for Rifampin-Resistant Tuberculosis (NEJM)
• Beta lactam allergy association with surgical site infections (JPIDS)
• Effect of Macrolides on mortality in Bacteremic Pneumonia (CID)
• Association of repeated blood cultures with mortality in adult patients with Gram-Negative Bacilli Bacteremia (OFID)
• Evaluating predictive value of surgical resected proximal bone margins in Diabetic foot Osteomyelitis with clinical outcomes (OFID)
• Burden of serious Fungal Infections in India (OFID)
• Bartonella quintana transmitted by head lice (CID)
• Balamuthia mandrillaris Granulomatous Amoebic Encephalitis (JPIDS)
• Detecting Leishmania in dogs (PLOS NTD)
• Primer on home infusion administration methods (OFID)
• Biomarkers of infection or sepsis at the bedside (ICM)
• Implementation roadmap for establishing remote infectious disease specialist support in resource-limited settings (OFID)
• Perceptions and reality of antimicrobial prescribing during the transition to comfort measures (OFID)
• Can the future of ID escape the inertial dogma of its past? (OFID

Music is by Ronald Jenkees

On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Human Rabies in Texas, 2021 (CDC)
• Human rabies despite post-exposure prophylaxis (The Lancet)
• The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet)
• An update on eukaryotic viruses revived from ancient permafrost (bioRx)
• Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM)
• Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID)
• Salmonella enteritidis cardiovascular implantable electronic device infection (OFID)
• Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID)
• Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID)
• Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID)
• Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID)
• Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID)
• Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID)
• Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID)
• Factors contributing to delayed academic advancement of women in infectious diseases (OFID)
• Characterization of problematic alcohol use among physicians (JAMA)
• Alpha-gal syndrome in the ID clinic (OFID)
• Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet)

Music is by Ronald Jenkees

On episode #17 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 11/24/22 – 12/8/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Antiretroviral drugs for treatment and prevention of HIV infection in adults (JAMA)
• Outcomes of short versus long duration of antibiotic therapy for residual osteomyelitis in diabetic foot infection (Journal of Antimicrobial Chemotherapy)
• Rectal culture-based versus empirical antibiotic prophylaxis to prevent infectious complications in men undergoing transrectal prostate biopsy (CID)
• Outbreak of Burkholderia stabilis infections associated with contaminated nonsterile multiuse ultrasound gel (CDC)
• Factors associated with receiving longer than recommended therapy among culture-negative pulmonary tuberculosis patients (OFID)
• Seasonality of healthcare-associated Stenotrophomonas maltophilia (ASHE)
• Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (The Lancet)
• Characteristics of antifungal utilization for hospitalized children in the United States (ASHE)
• Cutaneous blastomycosis presenting as a nonhealing wound (NIH)
• Evaluation of the diagnostic accuracy and clinical utility of fungla profile (OFID)
• Parasitic infection increases risk-taking in a social, intermediate host carnivore (Nature)
• Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense (The Lancet)
• Simple nodular cutaneous Leishmaniasis caused by Autochthonous Leishmania orientalis (AJTMH)
• Emerging and Reemerging Infectious Diseases (NEJM)

Music is by Ronald Jenkees

On episode #16 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 11/9/22 – 11/23/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Recommendations of the advisory committee on immunization practices for measles, mumps, rubella (CDC)
• Bacteremia with anaerobic bacteria and association with colorectal cancer (CID)
• Factors impacting the yield of image-guided biopsy in native vertebral osteomyelitis (OFID)
• Development of a clinical prediction score to inform tuberculosis treatment among children with HIV (OFID) 
• First detection and molecular identification of Rickettsia massiliae, a human pathogen (PLOS)
• Short-course vs long-course antibiotic therapy for children with nonsevere community-acquired pneumonia (JAMA)
• The timing of preoperative urinary tract infection influences the risk of prosthetic joint infection following primary total hip and knee arthroplasty (JOA)
• Recurrent candidemia: trends and risk factors among persons residing in 4 US States (OFID)
• Spread of Sporothrix spp through respiratory droplets from infected cats (Medical Mycology)
• Comparison of mold active triazoles as primary antifungal prophylaxis in patients with newly diagnosed acute myeloid leukemia (CID)
• Geographic distribution of dimorphic mycoses in the United States (CID)
• Knowledge, experiences, and practices of women affected by female genital schistosomiasis in rural Madagascar (PLOS NTDs)
• Dynamic immune profile in French Toxoplasmosis patients 
• White-Tailed deer are susceptible to the agent of classical sheep scrapie after experimental oronasal exposure (JID)
• The Lanzhou Brucella Leak: The largest laboratory accident in the history of Infectious Diseases (CID)

Music is by Ronald Jenkees

On episode #15 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 10/27/22 – 9/9/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Clinical presentation and severity of adenovirus detection alone vs adenovirus co-detection with other respiratory viruses in US children (JPID)
• Effectiveness of different antimicrobial strategies for staphylococcal prosthetic joint infection (OFID)
• Clinical impact of ceftriaxone resistance in E. coli bloodstream infections (OFID) 
• Adjunctive Gentamicin and Rifampin in staphylococcal prosthetic valve Endocarditis (OFID)
• Diagnostic performance of physician gestalt for bacteremia in patients in the process of being admitted with suspected infection (OFID)
• Effectiveness of quinolone prophylaxis in pediatric acute leukemia and hematopoietic stem cell transplantation (OFID)
• Risk factors for Vancomycin drug reaction with Eosinophilia and Systemic symptoms syndrome (JAMA)
• Prospective evaluation of the fungitell 1>3 beta-d-glucan assay as a diagnostic tool for invasive fungal disease (Wiley)
• Safety and efficacy of a monoclonal antibody against malaria in Mali (NEJM)
• Hospitalizations associated with strongyloidiasis in the United States (CID) 
• Prophylactic benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs (PLOS NTD)
• Baker’s dozen of top antimicrobial stewardship intervention publications for hospitalized patients (OFID)
• Baker’s dozen of top antimicrobial stewardship intervention publications in non-hospital care settings in 2021 (OFID)
• Medical student debt and the US ID workforce (CID)

Music is by Ronald Jenkees

On episode #14 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 10/13/22 – 10/26/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Relative Effectiveness of cell-based versus egg-based quadrivalent Influenza vaccines in adults (OFID)
• Oral is the new iv. challenging decades of Blood and Bone Infection Dogma (American Journal of Medicine)
• The burden of bacterial antimicrobial resistance in the WHO European region in 2019 (The Lancet)
• What is the appropriate dose, route and duration of antibiotic therapy for pediatric acute hematogenous osteomyelitis? (JPIDS)
• How generalizable are Randomized Controlled Trials in Staphylococcus aureus Bacteremia? (CID)
• Current treatments against mucormycosis and future directions (PLOS)
• The Effect of regularly dosed Acetaminophen vs no Acetaminophen on renal function in Plasmodium knowlesi Malaria (IDSA)
• The value of metagenomic next-generation sequencing in Leishmaniasis diagnosis (OFID)
• AmBisome monotherapy and combination AmBisome–Miltefosine therapy for the treatment of Visceral Leishmaniasis in patients coinfected With HIV (CID)
• Does Calcified Neurocysticercosis affect migraine characteristics and treatment responsiveness? (ASTMH)
• Association between personal ambient carbon dioxide level monitoring and incidence of Tuberculosis infection (CID)
• Change in the perception of oral antibiotics among medical students (OFID)
• Impact of antivenom administration on the evolution of cutaneous lesions in loxoscelism (PLOS)

Music is by Ronald Jenkees

On episode #13 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 9/29/22 – 10/12/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Efficacy and safety of switching to Dolutegravir/Lamivudine versus continuing Tenofovir Alafenamide (CID)
• Antibiotic combinations reduce Staphylococcus aureus clearance (Nature)
• Cholera Vaccine: Recommendations of the advisory committee on immunization practices (CDC)
• Detection of Treponema pallidum DNA during early syphilis stages (CID)
• Association between toxoplasmosis and bipolar disorder (Journal of Psychiatry)
• The efficacy of soap against schistosome cercariae (PLOS NTD)
• Recurrent ESBL Escherichia coli urosepsis in a pediatric renal transplant patient (NIH)
• After action review of the response to an outbreak of Lassa fever in Sierra Leone (PLOS NTD)

Music is by Ronald Jenkees

On episode #12 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 9/15/22 – 9/28/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Use of long-acting cabotegravir plus rilpivirine for people living with HIV-1 (HIV Medicine)
• Effectiveness of different antimicrobial strategies for staphylococcal prosthetic joint infection (OFID)
• Antibiotic Treatment Duration in Pseudomonas aeruginosa ventilator associated pneumonia (CID)
• Polymicrobial Foot Infection Patterns are common & associated With treatment failure (OFID)
• Faecal microbiota transplantation for first or second C. difficile infection (EarlyFMT) 
• Impact of Enterococcus faecalis endocarditis treatment on risk of relapse (CID)
• Comparison between culture-positive and culture-negative septic shock in patients (NIH)
• Evaluation of serum mucorales PCR for the diagnosis of Mucormycoses (CID)
• Humanized transgenic mice are resistant to chronic wasting disease prions from Norwegian reindeer and moose (JID)
• Dentist’s visits and risk of brain abscess (CID)

Music is by Ronald Jenkees

On episode #11 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 9/1/22 - 9/14/22.

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Links for this episode

• Post-Ebola symptoms infection (CID)
• Legionella identified as cause of cluster of pneumonia cases (PAHO)
• Frequency of exposure to antibiotics for enteropathogenic bacteria among young children (PNAS)
• Should Linezolid replace Clindamycin as the adjunctive antimicrobial of choice in Toxic Shock Syndrome (CID)
• Treatment with a three-drug regimen for Pulmonary Tuberculosis (OFID)
• The skip phenomenon in Staphylococcus Aureus Bacteremia (Science Direct)
• The relationship between antibiotic agent and mortality in patients with Febrile Neutropenia (OFID)
• Antibiotic indications and appropriateness in the pediatric intensive care unit (CID)
• Clinical features and treatment outcomes of Pulmonary Mycobacterium avium-intracellulare complex (OFID)
• Outcomes of partial oral antibiotic treatment for complicated S. Aureus Bacteremia in drug users (CID)
• Short-versus long-course antibiotic treatment for uncomplicated vancomycin-resistant enterococcal bacteraemia (CMI)
• Infectious Disease Consults of Pseudomonas aeruginosa bloodstream infection and impact on health outcomes (OFID)
• Paracoccidioidomycosis: current status and future trends (Clinical Microbiology)
• Comparative outcomes of Candida Auris Bloodstream Infections (CID)
• Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical Malaria (The Lancet)
• Leishmaniasis: Diagnosis and Treatment in the United States (JPIDS)
• Malaria Surveillance — United States, 2018 (CDC)
• Anti-bacteriophage immunity in phage therapy (JID)
• Improving understanding and utilization of the antibiogram among medical residents (Cambridge) 

Music is by Ronald Jenkees

On episode #10 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 8/17/22 – 8/31/22.

Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Tomato flu outbreak (Ped Inf Dis)
• Rabies vaccination of dogs (PLoS NTD)
• Repeat revision TKR (Arch Orthopedic Trauma Surg)
• Cat scratch fever (Open Forum Inf Dis)
• Treatment of post transplant asymptomatic bacteruria (Transplant Inf Dis)
• Shorter antibiotic courses in immunocompromised (Clin Micro Inf)
• Risk of cardiovascular implantable electronic device infection (Open For Inf Dis)
• Diagnosis of leprosy and cerebral coenurosis (Open For Inf Dis)
• Enterococcus central line infection (Eur J Clin Micr Inf Dis)
• Treatment of otitis media (J Pediatrics)
• Fungal infections in US (CDC)
• Surveillance for fungal infections US (CDC)
• Cryptococcal antigenemia in AIDS (Clin Inf Dis)
• Intestinal parasites in medieval UK (Int J Paleopathology)
• Nephrotoxicity of vancomycin (Clin Inf Dis)
• Administration of beta-lactam before vancomycin (Clin Inf Dis)
• Early beta-lactam catches the germ (Clin Inf Dis)
• Machines that help machines help patients (Curr Clin Oncol)
• In-person vs telemedicine (Open For Inf Dis)
• Impact of COVID-19 on community hospital acquired infections (Clin Inf Dis)

Music is by Ronald Jenkees

On episode #9 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 8/4/22 – 8/17/22.

 

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Zoonotic henipavirus in febrile patients in China (NEJM)
• Role of prospective monitoring, pre-emptive and prophylactic therapy for human Herpesvirus-6 after stem cell transplantation (OFID)
• Tuberculosis outbreak in the USA linked to bone graft product (Lancet ID)
• Surgical and medical management of Diabetic Foot Osteomyelitis (OFID)
• Increase in Pediatric Intracranial Infections during COVID-19 Pandemic (CDC)
• Incidence of Acute Chest Syndrome in children with Sickle Cell Disease following Pneumococcal vaccine (JAMA)
• Antibiotic resistance genes in the gut microbiota of mothers (Nature Microbiology)
• Clinical characteristics, health care utilization, and outcomes among patients for Invasive Mold Disease (OFID)
• Low-Dose subcutaneous/intravenous Monoclonal Antibody to prevent Malaria (NEJM)
• Revisiting practice of the treatment of Toxoplasmic Encephalitis
• Phase two trial of oral fexinidazole in adults with chronic indeterminate Chagas disease (CID)
• Half of human pathogenic diseases can be aggravated by climate change (Nature)
• The Impact of standardized infectious diseases consultation on Postsplenectomy care and outcomes
• Potential value and patient confidentiality implications of infectious disease clinician peer consultations via social media (OFID)

Music is by Ronald Jenkees

On episode #8 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 7/21/22 – 8/3/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Pediatric hepatitis linked to infection with two viruses (BMJ) 
• Protection duration of Yellow Fever vaccination (CID)
• Impact of CSF panel on duration of treatment (OFID)
• Cluster of Parechovirus infections in infants (MMWR)
• Molecular ecology and risk factors for Escherichia coli (Journal of Antimicrobial Therapy) 
• Melioidosis endemic in areas of the Mississippi gulf coast (CDC)
• Early switch from intravenous to oral antibiotics in infections (OFID)
• Duration of therapy and the use of Quinolone/Rifampin-Based regimens for joint infections (OFID)
• Efficacy of Doxycycline for mild-to-moderate community-acquired Pneumonia in adults (CID)
• Effectiveness of a Vancomycin dosing protocol (Cambridge Core)
• Outcomes of Fungemia in patients receiving extracorporeal membrane oxygenation (IDSA) 
• Malaria transmission intensity likely modifies RTS, S/AS01 efficacy (IDSA)
• Ultrashort course antibiotics for suspected pneumonia (CID)

Music is by Ronald Jenkees

On episode #7 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 7/7/22 – 7/20/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients (Eurosurveillance) 
• The impact of churn on HIV outcomes in the southern United States (OFID)
• Health Advisory: Recent Reports of PeV in the US (CDC)
• Cytomegalovirus viremia as risk factor for mortality in HIV-associated meningitis (International Journal of Infectious Diseases)
• Ghana declares its first outbreak of Marburg virus disease (BMJ)
• Case series of children with acute hepatitis and human adenovirus (NEJM)
• Pharmacokinetic variability of vancomycin in meningitis patients (Journal of Clinical Pharmacy and Therapeutics)
• Association of vancomycin plus piperacillin in critically ill adults (Intensive Care Medicine)
• Comparison of Sequential Dalbavancin to SOC treatment for bloodstream infections (OFID)
• Outbreak of sexually transmitted drug resistant Shigella sonnei in the UK (Lancet ID)
• Listeria illness and deaths associated with ongoing contamination of ice cream products (CID)
• Antibiotics for preventing recurrent uninary tract infections (OFID)
• Congenital tuberculosis after In-vitro fertilization (CID)
• Enhancing diagnostics in orthopedic infections (Journal of Clinical Microbiology)
• Screening for ocular finding among patients with candidemia (CDC)
• Effects of day-to-day variation of Opisthorchis viverrini antigen in urine (PLOS ONE)
• Disposable versus reusable medical gowns (The American Journal of Infection Control)

Music by Ronald Jenkees

On episode #6 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 6/23/22 – 7/6/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Analysis of acute Hepatitis of unknown etiology in children aged (CDC)
• A contemporary review of Monkeypox for healthcare workers (IDSA)
• Rapid antigen test for detection of orthopoxviruses (The Lancet)
• Decision making regarding anal cancer screening in HIV-positive people (IDSA)
• Updated guidelines for testing of transplant candidates (CDC)
• Effect of automated telephone infectious disease consultations to nonacademic hospitals (JAMA)
• Prevalence and predictors of Pseudomonas aeruginosa among hospitalized patients (OFID)
• High yield of blood cultures in the diagnosis of cellulitis and more in elderly patients (OFID)
• The impact of glove and gown use on C. difficile (CID)
• Antibiotic therapeutic drug monitoring in critically ill patients CID)
• Utility of induced sputum in assessing bacterial etiology in children (JPIDS)
• Epidemiology of UTI infections due to Enterobacterales (OFID)
• Analysis of linezolid combined with methadone or buprenorphine (OFID)
• Management of histoplasmosis by ID physicians (OFID)
• Increased deaths from fungal infections during pandemic (CID)
• Clinical utility of antifungal susceptibility testing (JAC)
• Spotlight on sporothrix and sporotrichosis (Mycopathologia) 
• Guidelines on diagnosing, preventing, and managing cryptococcal disease in HIV-positive adults and children (WHO)
• Dracunculiasis eradication: end stage challenges (ASTMH) 
• Range expansion of native and invasive ticks (JID)
• Vaccine-hesitant moment (NEJM)
• FDG-PET-CT compared with CT for persistent fever in high-risk patients (The Lancet)

Intro music is by Ronald Jenkees

On episode #5 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 6/8/22 – 6/22/22.

Host: Daniel Griffin

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Links for this episode

• Effect of testing for respiratory pathogens on antibiotic use of children (JAMA)
• Outbreak of hepatitis in children (Intensive Care Medicine)
• Leptospirosis in retirees in rural areas (IDSA)
• Comparing Ceftolozane/Tazobactam to standard of care in the management of neutropenia and fever in patients with hematological malignancies (IDSA)
• Development of an electronic algorithm to target outpatient antimicrobial stewardship efforts for acute bronchitis and pharyngitis (IDSA)
• Compassionate-use of phages in twenty patients with drug-resistant mycobacterial disease (CID)
• Microbial Cell-Free DNA Identifies the Causative Pathogen in Infective Endocarditis (CID)
• The source of the Black Death in fourteenth-century central Eurasia (Nature)
• Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases (OFID)
• WHO guideline for the treatment of visceral leishmaniasis in HIV co-infected patients (WHO)
• Broad antimicrobial resistance in a case of relapsing babesiosis successfully treated with tafenoquine (CID)
• Human Filariasis in Travelers and Migrants (CID) 
• Therapeutic hyperthermia is associated with improved survival in afebrile critically ill patients with sepsis (Critical Care Medicine)
• Does a school-based intervention to engage parents change opportunity for handwashing with soap at home? (PLOS NTD)
• Infectious diseases compensation in the USA (The Lancet)

Intro music is by Ronald Jenkees

On episode #4 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 5/25/22 – 6/8/22. Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Clinical features and managements of human Monkeypox (The Lancet)
• Clinical course and outcome of human Monkeypox in Nigeria (CID)
• Monkeypox outbreak report in United States – May 2022 (CDC)
• Travel notice for Monkeypox (CDC)
• Immunoglobulin-free strategy to prevent HBV mother to children transmission in Cambodia (The Lancet)
• CD4 T-cell depletion prevents Lassa fever associated hearing loss in mouse model 
• Economic and clinical burden associated with infections after cell transplant (Transplant infectious disease)
• Multistate outbreak of Listeria monocytogenes infections linked to soft Hispanic-Style cheese – United States, 2021 (CDC)
• Evaluation of Mycobacterium avium complex pulmonary disease treatment completion and adherence to ATS/IDSA guidelines (NIH)
• Case Report: Pulmonary leptospirosis misdiagnosed as COVID-19 (ASTMH)
• Association of inappropriate outpatient pediatric antibiotic prescriptions with adverse drugs events (JAMA) 
• Exploration of Primary care clinician attitudes associated with prescribing antibiotics for asymptomatic bacteriuria (JAMA)
• Case Report: Bartonella Quintana endocarditis in a child from Northern Manitoba, Canada
• Chlorhexidine and Mupirocin for Clearance of Methicillin Resistant Staphylococcus aureus Colonization After Hospital Discharge (CID)
• Daptomycin-Resistant Enterococcus Bacteremia Is Associated With Prior Daptomycin Use and Increased Mortality After Liver Transplantation (CID)
• Updated consolidated guidelines for Malaria (WHO)
• Podoconiosis: Clinical spectrum and microscopic presentations (PLOS)
• Pharmacist gender and physician acceptance of antibiotic stewardship recommendations (ICHE)
• Prevention of Neisseria gonorrhoeae with meningococcal B vaccine: a matched cohort study in Southern California (IDSA)

Intro music is by Ronald Jenkees Send your questions for Puscast to [email protected]

On the third episode of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 5/11/22 – 5/25/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

• Monkeypox Virus Infection in the United States and Other Non-endemic Countries—2022 (CDC)
• Monkeypox course (WHO)
• Monkeypox on TWiV 902 and TWiV Special
• Progress Toward Polio Eradication — Worldwide, January 2020–April 2022 (MMWR)
• Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection (NEJM)
• Rabies in a Dog Imported from Azerbaijan — Pennsylvania, 2021 (MMWR)
• Burden, clinical characteristics, risk factors, and seasonality of adenovirus 40/41 diarrhea in children in eight low-resource settings (Open For Inf Dis)
• Comparison of 8 vs 15 days of antibiotic therapy for Pseudomonas aeruginosaventilator-associated pneumonia in adults (Intensive Care Med)
• High prevalence of Pseudomonas aeruginosa carriage in residents of French and German long-term care facilities (Clin Micro Inf)
• Antibiotic treatment duration for community acquired pneumonia in outpatient children in high-income countries – a systematic review and meta-analysis (Clin Inf Dis)
• Follow-up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center (Open For Inf Dis)
• Meningococcal disease and immunization activities in Hajj and Umrah Pilgrimage: a review (Inf Dis Therapy)
• Treatment with reduced dose trimethoprim-sulfamethoxazole is effective in mild to moderate Pneumocystis jirovecii pneumonia in patients with hematologic malignancies (Clin Inf Dis)
• Occupational risk of cutaneous larva migrans: A case report and a systematic literature review (PLoS NTD)
• Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis (JID)
• Diagnosis and management of infective endocarditis in people who inject drugs(JACC)
• A mechanistic model of snakebite as a zoonosis: Envenoming incidence is driven by snake ecology, socioeconomics and its impacts on snakes (PLoS NTD)
• Strategies to prevent central-line associated bloodstream infections in acute-care hospitals (Infection Control & Hosp Epi)
• Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute care hospitals (Infection Control & Hosp Epi)
• Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis (PLoS NTD)
• Chagas Disease: The New HIV/AIDS of the Americas (PLoS NTD)
• Digital Strategy and Social Media in Infectious Diseases (Clin Inf Dis)

Intro music is by Ronald Jenkees Send your questions for Puscast to [email protected]

On the the second episode of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/27/22 – 5/11/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

•Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022(MMWR) •Case Series of False-Positive HIV Test Results in Pediatric Acute Lymphoblastic Leukemia Patients Following Chimeric Antigen Receptor T-Cell Therapy: Guidance on How to Avoid and Resolve Diagnostic Dilemmas (J IDSA) •Immunological correlates of prevention of the onset of seasonal H3N2 influenza (JID) •Use of a Modified Preexposure Prophylaxis Vaccination Schedule to Prevent Human Rabies: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 (MMWR) •Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults(MMWR) •The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children (J PIDS) •Factors Potentially Contributing to the Contamination of Packaged Leafy Greens Implicated in the Outbreak of Salmonella Typhimurium During the Summer of 2021 (FDA) •Short-course intravenous antibiotics for young infants with urinary tract infection (Arch Dis Children) •Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence (Clin Inf Dis) •2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults (Clin Inf Dis) •Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa (Lancet) •Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults (JAMA) •Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management (Clin Inf Dis) •Frequency and Duration of, and Risk Factors for, Diagnostic Delays Associated with Histoplasmosis (J Fungi) •Intestinal parasitic infections and associated factors among people living with HIV attending Dessie Referral Hospital, Dessie town, North-east Ethiopia (AIDS Res Ther) •Association of zoonotic protozoan parasites with microplastics in seawater and implications for human and wildlife health (Nat Sci Rep) •Climate change increases cross-species viral transmission risk (Nature and TWiV 898)

Intro music is by Ronald Jenkees Send your questions for Puscast to [email protected]

On the first episode of the Infectious Disease Puscast, Daniel and Sara bring Marc Crislip’s well known Puscast back to life, and present a review of the infectious disease literature for the previous two weeks, 4/13 – 4/27/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• Rabies from an anteater (MMWR)
• Oral Tebipenem Pivoxil Hydrobromide in Complicated UTI (NEJM)
• Therapeutic monitoring of vancomycin for serious MRSA infections (IDSA)
• Time to retire Vancomycin for MRAS Endovascular Infections? (Op Forum Inf Dis)
• Impact of ID consultation on outcome of patients with enterococcal bacteremia (Op Forum Inf Dis)
• Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia (JAMA)
• Effect of Antimicrobial Prophylaxis Duration on Health Care-Associated Infections After Clean Orthopedic Surgery (JAMA)
• Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection (Op Forum Inf Dis)
• Vehicle Windshield Wiper Fluid as Potential Source of Sporadic Legionnaires’ Disease in Commercial Truck Drivers (MMWR)
• Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM)
• High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine (JID)
• Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d’Ivoire (J Inf Dis)

Intro music is by Ronald Jenkees Send your questions for Puscast to [email protected]