Merle and Lee talk to Christos Lynteris, a medical anthropologist, on the Third Pandemic of Plague and its impact across the globe between 1894 and 1959. The pandemic is discussed in terms of its origins, spread and social, political and epistemological consequences, but also in terms of establishing the notion of the pandemic in medicine and beyond. Christos offers insights into the long-lasting legacies of the pandemic, including the development of the scientific study of zoonosis, epidemic photography, and various technologies of epidemic control.