Arafaat Valiani (University of Oregon) has a conversation with the Infectious Historians about genomic and genetic research with indigenous communities. Arafaat goes over what is genomic research, then describes how tests work and the bioethical debate surrounding them. He describes some of the different approaches among biomedical researchers that approach marginalized communities. The conversation moves on to discuss some of the practicalities of working with and within these communities, followed by a reflection about whether other communities should adopt similar practices as well. The interview finishes with a discussion of the role of AI within genomic research.