Jim Harris (Ohio State University) joins Merle and Lee to offer an overview of the development of vaccinations since the first smallpox vaccine in the late 18th century. The discussion touches upon pre-18th century practices for treating smallpox, before examining the spread in vaccination use. The second part of the interview moves to discuss anti-vaccination ideas and movements in their socio-cultural contexts. Finishing at the present, it covers the main factors influencing anti-vaccination as the group attempts to understand it as a historical phenomenon.