Stephanie Marciniak (Penn State University) joins Merle and Lee to discuss some of the fascinating developments in studying historical diseases from a scientific perspective: ancient DNA and more broadly paleogenetics. Stephanie provides some context for this research approach, before touching upon several related topics: the process of researching ancient DNA, the diseases that we can (or cannot) identify in human remains, some of the research questions that interest ancient DNA scientists, and a few issues concerning numbers of remains and of positive identifications of disease.