#10 Parkinson’s Disease: Just a movement disorder? Brain-to-brain with Elisa Percolla.

Do you know someone who has Parkinson’s disease? It is often characterized by trembling hands, but actually has many more aspects. Elisa Percolla is a scientific researcher at the institute of Cognitive Science in Osnabrück. She wrote her master thesis on Parkinson’s disease and studied the brains of patients with EEG. During the interview Elisa describes her way into the field of cognitive science and how the broadness of the field can sometimes go hand in hand with a feeling of inaccuracy since you can never be equally good at each sub-discipline. She proceeds to explain that we should sometimes be a little more lenient with ourselves. Listen to this episode to learn how symptoms of Parkinson’s disease show, what underlying mechanisms are, and what the current state of research in treatment is!

Related literature:

– Last discoveries (EEG and alpha frequency band): Özkurt T. E. (2024). Abnormally low sensorimotor alpha band nonlinearity serves as an effective EEG biomarker of Parkinson’s Disease. Journal of neurophysiology, 10.1152/jn.00272.2023. Advance online publication. https://doi.org/10.1152/jn.00272.2023 – Noradrenaline and not just Dopamine: new frontier of Parkinson’s Disease Research Barone, P. (2010). Neurotransmission in Parkinson’s disease: Beyond dopamine. European journal of neurology : the official journal of the European Federation of Neurological Societies, 17:364–76. Delaville, C., De Deurwaerdère, P., and Benazzouz, A. (2011). Noradrenaline and Parkinson’s disease. Frontiers in systems neuroscience, 5:31. – Non-motor Symptoms in Parkinson’s Disease (more general) Bodis-Wollner, I., Tzelepi, A., Sagliocco, L., Bandini, F., Mari, Z., Pierantozzi, A., Ogliastro, E., Kim, J., Ko, C., and Gulzar, J. (1998). Visual processing deficit in Parkinson’s disease, pages 606–611. Lees, A., Hardy, J., and Revesz, T. (2009). Spectrum of non-motor symptoms in Parkinson’s disease. Lancet, 373(9680):2055–2066. Kumaresan, M. and Khan, S. (2021). Spectrum of non-motor symptoms in parkin- son’s disease. Cureus, 13. Schapira, A., Ray Chaudhuri, K., and Jenner, P. (2017). Non-motor features of Parkinson’s disease. Nature Reviews Neuroscience, 18. Hobson, D., Lang, A., Martin, W., Razmy, A., Rivest, J., Fleming, J., Pourcher, E., and Members, C. (2002). Excessive daytime sleepiness and sudden-onset sleep in parkinson’s disease: A survey by the canadian movement disorders group. JAMA The Journal of the American Medical Association, 287:455–463. Kehagia, A. (2016). Neuropsychiatric symptoms in parkinson’s disease: Beyond complications. Frontiers in Psychiatry, 7. Doty, R. (2012). Olfactory dysfunction in parkinson disease. Nature reviews. Neurology, 8:329–39. Kehagia, A., Barker, R., and Robbins, T. (2012a). Cognitive impairment in parkin- son’s disease: The dual syndrome hypothesis. Neuro-degenerative diseases, 11. – Neural correlates of motor and non-motor symptoms correspondence: Marquez, J., Hasan, S. M. S., Siddiquee, M., Luca, C., Mishra, V., Mari, Z., and Bai, O. (2020). Neural correlates of freezing of gait in parkinson’s disease: An electrophysiology mini-review. Frontiers in Neurology, 11. – Previous work on Event-related Potential Components as biomarkers of Impaired Novelty Detection in Parkinson’s Disease: Solıs-Vivanco, R., Ricardo-Garcell, J., Rodrıguez-Camacho, M., Prado-Alcala, R., Rodriguez, U., Rodrıguez-Violante, M., and Rodrıguez-Agudelo, Y. (2011). Involuntary attention impairment in early Parkinson’s disease: An event-related potential study. Neuroscience letters, 495:144–9. Solıs-Vivanco, R., Rodrıguez-Violante, M., Cervantes-Arriaga, A., Justo-Guillén, E., and Ricardo-Garcell, J. (2018). Brain oscillations reveal impaired novelty detection from early stages of parkinson’s disease. NeuroImage: Clinical, 18. Solıs-Vivanco, R., Rodrıguez-Violante, M., Rodrıguez-Agudelo, Y., Schilmann, A., Rodrıguez-Ortiz, U., and Ricardo-Garcell, J. (2015). The p3a wave: A re- liable neurophysiological measure of parkinsońs disease duration and severity. Clinical Neurophysiology, 126. Lagopoulos, J., Gordon, E., Barhamali, H., Lim, C. L., Li, W., Clouston, P., and Morris, J. (1998). Dysfunctions of automatic (p300a) and controlled (p300b) processing in Parkinson’s disease. Neurological research, 20:5–10. – Vibrotactile cueing and Parkinsonian Freezing of Gait Kaiser, V. (2021). The impact of a vibrotactile cueing device on freezing of gait and other gait impairments in parkinson’s disease – a longitudinal study.

Credits:

Produced by: Sophie Kühne and Alina Ohnesorge Logo by: Annika Richter Music by: Jan-Luca Schröder