S2 #23 What does a (brain) pacemaker do in your brain? Brain-to-brain with Dora Meyer-Doll.

Doras ongoing study: https://www.drks.de/DRKS00024593

Literature: Gadot, Ron et al. “Efficacy of deep brain stimulation for treatment-resistant obsessive-compulsive disorder: systematic review and meta-analysis.” Journal of neurology, neurosurgery, and psychiatry, jnnp-2021-328738. 20 Sep. 2022, doi:10.1136/jnnp-2021-328738 Schläpfer, T.E., Kayser, S. “Deep Brain Stimulation for Treatment-Resistant Depression” Klin Neurophysiol 2014; 45: 113–117, http://dx.doi.org/10.1055/s-0034-1375605 Human Medial Forebrain Bundle (MFB) and Anterior Thalamic Radiation (ATR): Imaging of Two Major Subcortical Pathways and the Dynamic Balance of Opposite Affects in Understanding Depression Volker A. Coenen, M.D. Jaak Panksepp, Ph.D. Trevor A. Hurwitz, M.D. Horst Urbach, M.D. Coenen, V.A.; Schlaepfer, T.E.; Sajonz, B.E.A.; Reinacher, P.C.; Döbrössy, M.D.; Reisert, M. “The Heart Asks Pleasure First”— Conceptualizing Psychiatric Diseases as MAINTENANCE Network Dysfunctions through Insights from slMFB DBS in Depression and Obsessive–Compulsive Disorder. Brain Sci. 2022, 12, 438. https:// doi.org/10.3390/brainsci12040438 Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook Thomas E Schlaepfer*,1,2, Bettina H Bewernick1, Sarah Kayser1, Rene Hurlemann1 and Volker A Coenen3

A book on the topic: The pleasure shock, Lone Frank Some (german) documentaries: Hunting For Hedonia ( https://vimeo.com/ondemand/huntingforhedonia/363300769?autoplay=1 ) Schrittmacher gegen Depressionen( https://www.youtube.com/watch?v=lZPB2TKUhYE ) Landesschau Baden-Württemberg: Ein Schrittmacher im Hirn bändigt seine Depression ( https://www.ardmediathek.de/video/landesschau-baden-wuerttemberg/ein-schrittmacher-im-hirn-baendigt-seine-depression/swr-bw/Y3JpZDovL3N3ci5kZS9hZXgvbzE5MTQzOTA )

Podcast Credits: Produced by: Imogen Hüsing, Clara Kühne, Sophie Kühne, Sönke Lülf, Elisa Palme and Leslie Wolk Logo by: Annika Richter Music by: Jan-Luca Schröder Write us an email to: [email protected] Contact us on Instagram: @kaleidoscience_pod