How to Improve Your Healthspan Using DNA Insights with Dr. Bartek Nogal

In this episode of Longevity By Design, Dr. Gil Blander interviews Dr. Bartek Nogal about genetic predispositions to conditions of aging. This episode goes deep into explaining how to improve your healthspan using DNA insights. Dr. Blander and Dr. Nogal talk about bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevated ApoB, grip strength, and more. Knowing your genetic predispositions to certain traits can help you fine tune your wellness plan, and Dr. Nogel and Dr. Blander explain how to do so in this episode.

Episode timestamps: 

• Introduction: (0:00–3:40) 
• What led Dr. Nogel to become a scientist (3:40–5:32)
• Moving from academia to InsideTracker (5:32–7:28) 
• What is DNA? (7:28–9:12) 
• How similar is DNA across animal species? (9:12–10:05) 
• Single Nucleotide Polymorphisms (SNPs) (10:05–14:10)
• How polygenic scores are calculated (14:10–17:25) 
• Defining heritability (17:25–22:53) 
• ApoB is highly heritable (22:53–24:24) 
• Why you should measure blood and DNA together (24:24–31:50) 
• Science behind the new polygenic scores added to InsideTracker (31:50–38:20)
• How many SNPs are in the ApoB score? (38:20–41:20)
• Visceral fat (41:20–45:07) 
• Age related muscle weakness (45:07–49:10) 
• Bone mineral density (49:10–51:45) 
• Chronotype—genetic predisposition to morningness (51:45–55:37)
• Lifespan DNA score (55:37–60:10) 
• Epigenetic age acceleration (60:10–1:06:40)
• Cognitive aging (1:06:40–1:08:20)
• Age at menopause (1:08:20–1:10:40)
• Top tip for healthspan: (1:10:40–end) 

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