Lost Women of Science

In the early 1960s, chemist Dr. Dora Richardson synthesized a chemical compound that became one of the most important drugs to treat breast cancer: tamoxifen. Although her name is on the original patent, her contributions have been lost to history. 

In the first episode of this two-part podcast, Katie Couric introduces us to Dora’s story. Lost Women of Science producer Marcy Thompson tracked down Dora’s firsthand account of the history of the drug’s development. This document, lost for decades, tells the story of how the compound was made and how Imperial Chemical Industries, where Richardson worked, almost terminated the project because the company was hoping to produce a contraceptive, not a cancer therapy.

While researching her book about thalidomide in America, Jennifer Vanderbes discovered that there were far more survivors in the U.S. than originally thought – at least ten times more. These survivors were born with shortened limbs and other serious medical conditions after their mothers unwittingly took thalidomide in the early 1960s in so-called clinical trials. Wonder Drug tells the story of Vanderbes’ trek across the U.S. in search of these thalidomide survivors. It also revisits the role of the U.S. Food and Drug Administration medical reviewer Dr. Frances Oldham Kelsey – the subject of our recent five-part season – who refused to approve thalidomide for sale in the U.S. In the process of writing her book, Vanderbes became an advocate for the survivors, now in their sixties, and their search for justice and support. 

It’s September 2024 and a group of American thalidomide survivors arrive in Washington D.C. to lobby the government for support. More than 60 years have gone by since Frances Kelsey first stalled the New Drug Approval application from pharma company Merrell for thalidomide. Although she stopped the drug from going on the market in the U.S., hundreds of pregnant women still took thalidomide in Merrell’s so-called clinical trials, and many had babies with shortened limbs and serious medical conditions. Others had miscarriages or stillborn babies. Here we look at the legacy of thalidomide, the changes in drug regulations in the wake of the scandal, and what happened to our hero, Frances Kelsey. 

It’s the summer of 1962 and thalidomide has been off the market in Europe for months. But in the U.S., people are only just beginning to find out about the scandal. The Washington Post breaks the story and puts a picture of Frances Kelsey on the front page. She’s the hero who saved American lives. President John F. Kennedy gives her a medal and her image is splashed across newspapers around the country. At the end of the previous year, Merrell, the company that wanted to sell thalidomide in the U.S., had made a half-hearted attempt to contact some of the doctors who had been given millions of thalidomide samples for so-called clinical trials. Just how many pregnant women might have thalidomide in their medicine cabinets?

It’s 1961 and Widukind Lenz, a German pediatrician, is going door to door in his efforts to find out what is causing the epidemic of babies born with shortened limbs and other serious medical conditions. In the U.S., drug company Merrell is battling with Dr. Frances Kelsey at the Food and Drug Administration about the approval for thalidomide. She’s asking for data that shows it’s safe in pregnancy (spoiler alert: it’s not). Meanwhile, Merrell continues to send hundreds of thousands of thalidomide pills to doctors in so-called clinical trials. In November 1961, Dr. Lenz goes public with the results of his medical sleuthing and, as host Katie Hafner puts it, “the proverbial shit hits the proverbial fan.”

It’s the early 1960s and the German pharmaceutical market is booming. A sedative called Contergan is one of the bestselling drugs. Contergan’s active ingredient is thalidomide and it is touted as a wonder drug, a non-addictive sedative safer than barbiturates. In the U.S., the drug is called Kevadon, and its distributor is impatient to get the drug on the market. But Dr. Frances Kelsey, a medical examiner at the U.S. Food and Drug Administration, is stalling the approval of Kevadon. She wants more information from the manufacturer to prove it is safe. Meanwhile, doctors in Scotland and Australia are beginning to suspect thalidomide might, in fact, be very toxic. And in Germany, reports are beginning to emerge of a mysterious epidemic of babies born with missing limbs and other serious medical conditions, but doctors have no idea what's causing it.

In this first chapter of a new five-part season we meet Dr. Frances Oldham Kelsey, a physician and pharmacologist who joined the U.S. Food and Drug Administration as a medical reviewer in 1960. Before the year is out, Dr. Kelsey finds herself standing up to big pharma. 

It’s September 1960 and a thick New Drug Application lands on Dr. Kelsey’s desk. The drug has already been on the market in Europe for three years and Dr. Kelsey’s supervisors expect her to rubber stamp the application. The drug is called Kevadon. Active ingredient: thalidomide. And to Frances Kelsey’s keen eye, something looks off.

In the 1950s, a German drug company developed a new sedative that was supposed to be 100% safe: thalidomide. So safe, in fact, it was promoted to women as a treatment for morning sickness. It quickly became a bestseller. But in the early 1960s, shocking news started coming out of Europe. Thousands of babies were being born with shortened arms and legs, heart defects, and other serious problems. Many died. 

In the United States things were different, thanks to one principled, strong-minded skeptic who joined the Federal Drug Administration in 1960 as a medical reviewer. One of her first assignments was to review the approval application of that very wonder drug, thalidomide. But the application was, to her mind, flawed. 

Dr. Frances Oldham Kelsey was a physician, a pharmacologist, and a nitpicker who refused to be intimidated by big pharma.

Starting in September, a new five-part series from Lost Women of Science: The Devil in the Details, the story of Frances Oldham Kelsey, The Doctor Who Said No To Thalidomide. 

In the 1920s, when newspapers and magazines started to showcase stories about science, many of the early science journalists were women, working alongside their male colleagues despite less pay and outright misogyny. They were often single or divorced and, as Marcel Chotkowski LaFollette explains, writing for their lives. From Emma Reh, who traveled to Mexico to get a divorce and ended up trekking to archeological digs on horseback, to Jane Stafford, who took on taboo topics like sex and sexually transmitted diseases, they started a tradition of explaining science to non-scientists, accurately and with flair. 

By the second half of the 20th century, physicists were on a mission to find the ultimate building blocks of the universe. What you get when you zoom in all the way to the tiniest bits that can’t be broken down anymore. They had a kind of treasure map, a theory describing these building blocks and where we might find them. But to actually find them, physicists needed to recreate the blistering-hot conditions of the early universe, when many of these particles last existed. That’s why, in the mid-1970s, a major national laboratory entrusted Helen Edwards with a huge task: to oversee the design and construction of the most powerful particle accelerator in the world, the first of a new generation of particle colliders built to uncover the inner workings of the universe. 

Dr. Jess Wade is a physicist at Imperial College London who’s made it her mission to write and update the Wikipedia pages of as many women in STEM as she possibly can. She inspired us at Lost Women of Science to start our own Wikipedia project to ensure that all the female scientists we profile have accurate and complete Wikipedia pages. In this episode, Jess talks with us about what she does and why she does it. 

Dr. Nancy Hopkins, a molecular biologist who made major discoveries in cancer genetics, became an unlikely activist in her early fifties. She had always believed that if you did great science, you would get the recognition you deserved. But after years of humiliations — being snubbed for promotions and realizing the women's labs were smaller than those of their male counterparts — she finally woke up to the fact that her beloved MIT did not value women scientists. So measuring tape in hand, she collected the data to prove her point. In The Exceptions: Nancy Hopkins, MIT, and the Fight for Women in Science, Kate Zernike tells Nancy's story, which led to MIT’s historic admission of discrimination against its female scientists in 1999. Host Julianna LeMieux talks with Kate and Nancy about the journey.

 “The only time I ever saw something that I thought was abnormal…there was a human arm in the refrigerator,” said J. Peter Willard about his aunt, Mary Louisa Willard. Otherwise, he insisted, she was just “very normal.” But Mary Louisa Willard, a chemistry professor at Pennsylvania State University in the late 1920s, left a strong impression on most people, to say the least. Her hometown of State College, Pennsylvania, knew her for stopping traffic in her pink Cadillac to chat with friends and for throwing birthday bashes for her beloved cocker spaniels. Police around the world knew her for her side hustle: using chemistry to help solve crimes.

When Laura J. Martin decided to write a history of ecological restoration, she didn’t think she would have to go back further than the 1980s to uncover its beginnings. What she found, however, deep in the archives, was evidence of a network of early female botanists from the turn of the last century who had been written out of history. Wild by Design: The Rise of Ecological Restoration sets the record straight. It tells the stories of Eloise Butler, Edith Roberts and the wild and wonderful gardens they planted and studied. 

In our final episode, we explore Dorothy Andersen’s legacy — what she left behind and how her work has lived on since her death. Describing her mentor’s influence on her life and career, Dr. Celia Ores gives us a rare look at what Dr. Andersen was really like. We then turn to researchers, physicians, and patients, who fill us in on the many areas of progress that have grown out of Dr. Andersen’s work. These major developments include the discovery of the cystic fibrosis gene, the tremendous impact of the drug Trikafta, and the lifesaving potential of gene editing techniques. We end the episode with an update on the effect Trikafta has had on the lives of many CF patients, who can now expect to live a normal life. 

The missing portrait of Dr. Andersen takes us on a journey into the perils of memorialization and who gets to be remembered. Dr. John Scott Baird, Dorothy Andersen’s biographer, looks for the portrait, and Drs. Nientara Anderson and Lizzy Fitzsousa, former medical students at Yale University, explain how “dude walls” — the paintings of male scientists that line institutional walls — can have an insidious effect on those who walk past them every day. And we go back to Columbia University to give you an update on the hunt for the missing portrait.

Our associate producer, Sophie McNulty, rummages through boxes in a Connecticut basement, looking for clues to Dorothy Andersen’s life story. Pediatric critical care physician Dr. John Scott Baird, who published a biography of Dorothy Andersen in 2021, suggests we take a second look at the conventional wisdom surrounding the evolution of cystic fibrosis research in the 1950s. And in this updated episode, we interview science historian Margaret Rossiter, who coined the term “Matilda Effect” to describe how credit for work done by female scientists too often goes to their male colleagues. We examine how this affected Dorothy Andersen and her groundbreaking research into cystic fibrosis.

A few important things have happened in the three years since we first aired The Pathologist in the Basement, the story of Dr. Dorothy Andersen, the first to identify cystic fibrosis. It’s safe to say that Dr. Anderson is now a little less lost. In Episode 1, Dr. Andersen sleuths her way to the discovery of cystic fibrosis, a fatal disease that affects the lungs, the pancreas, and a host of other organs. So, who was Dorothy Andersen, and how did she come to make this seminal medical contribution?

When poet Jessy Randall started researching the lives of female scientists she became angry. And we certainly can relate here at Lost Women of Science. So many women made important discoveries but received little recognition. In this episode of Lost Women of Science Conversations, Randall talks to Carol Sutton Lewis about Mathematics for Ladies: Poems on Women in Science, the collection of poems born of that anger. They discuss what it means to be the first in a field, the ethics of poetic license, and the importance of female role models in STEM. Randall’s poems are about some of the women we’ve featured in our podcast, including the first Black female doctor, Rebecca Lee Crumpler, and the physicist Lise Meitner.

“We were each put on earth to torment the other,” says cognitive scientist Steven Pinker of Elizabeth Bates, a psychologist who challenged the prevailing theory about how humans acquire language. Bates believed that language emerges from interactions between our brains and our environments, and that we do not have an innate language capacity. To many, that sounds like an innocuous statement. But in making these claims, Bates challenged formidable linguists like Pinker and Noam Chomsky, placing herself at the center of a heated debate that remains unresolved half a century later.

Melba Phillips, who grew up on a farm in Indiana at the turn of the 20th century, was one of J. Robert Oppenheimer’s first graduate students at the University of California, Berkeley. Together they discovered the Oppenheimer-Phillips Process, which explained a particular kind of nuclear reaction. In this episode, we explain what that is, with a little help from generative AI. Phillips did not follow Oppenheimer to Los Alamos, and was vocal in her opposition to nuclear weapons. During the McCarthy era, she lost her teaching job, and did not return to academia until 1957. In 1962, then in her mid-fifties, she finally became a full professor at the University of Chicago.

Cecilia Payne-Gaposchkin was in her early 20s when she figured out what the stars are made of. Both she and her groundbreaking findings were ahead of their time. Continuing the legacy of women working at the Harvard College Observatory, Cecilia charted the way for a generation of female astronomers to come. This Best Of episode of Lost Women of Science follows Cecilia’s journey of discovery, journals her drive and determination against all odds, and takes you to the Harvard College Observatory itself to walk in Cecilia’s footsteps.

The year is 1897 and Annie Maunder, an amateur astronomer, is boarding a steamship bound for India from England. Her goal: to photograph a total solar eclipse. Like the many people whose gaze will turn upwards in North America on April 8, Maunder was fascinated by the secrets of the sun and was determined to travel the globe and unlock them. She understood that the few minutes of darkness during a solar eclipse presented a special opportunity to explore the nature of the sun. Her observations led to our greater understanding of how the sun affects the earth, but like so many early female scientists, her contributions and achievements have been forgotten.

In this episode of Lost Women of Science Conversations, Michelle Nijhuis talks to historian Catherine McNeur about how she rediscovered the lives and work of Elizabeth and Margaretta Morris, two natural scientists who made significant contributions to botany and entomology in the mid-19th Century. Elizabeth collected rare plant species and sent them to institutions around the world, and Margaretta not only discovered new insects but also helped farmers combat the pests that were devastating their fields. Nevertheless, by both design and accident, these women were lost to history. McNeur tells us how that happened and how, piece by piece, she recovered their stories.

While working at the Salk Institute in California, Ursula Bellugi discovered that sign language was made up of specific building blocks that were assembled following strict rules, much like in spoken language. Her subsequent discoveries about the complexities of sign language led both to linguistic breakthroughs and to changes in the way deaf people felt about signing. Bellugi demonstrated that sign language is as rich and complex as any spoken language. Her work deepened our understanding of what it means to communicate as humans.

Katharine “Kay” Way was a nuclear physicist who worked at multiple Manhattan Project sites. She was an expert in radioactive decay. But after the atomic bombs were dropped on Japan, she became increasingly concerned about the ethics of nuclear weapons. Dr. Way signed the Szilard Petition and worked to spread awareness of the moral responsibility surrounding atomic weaponry, including co-editing the influential One World or None: a Report to the Public on the Full Meaning of the Atomic Bomb, remaining an outspoken advocate for fairness and justice.

“Hoots and derision, which did not worry me at all,” Lilian Bland wrote, describing her visit to an airshow in Blackpool, England in 1909. She’d been telling everyone there that she intended to build and fly her own airplane. They were unimpressed. Lilian was undeterred. She built a DIY plane of bamboo, wood, and fabric, with a bicycle handlebar for steering and an engine she carried from England back to her home in Ireland. But would the Mayfly, as she called it, fly?

In the first of a new series we’re calling Lost Women of Science Conversations—and a fitting choice for Black History Month—we talk to Maria Smilios, author of a new book that tells the story of Black nurses who were lured from the Jim Crow South to work at a tuberculosis (TB) hospital called Sea View on Staten Island, N.Y. Facing unsanitary conditions and racial prejudice, these “Black Angels” cared for TB patients for decades before a cure that they helped develop was found. It’s a story of bravery and dedication that Smilios pieced together from oral histories and medical records because there were no archives that described these nurses’ work.

Sara Little Turnbull was a force in the world of material science and industrial design. It’s safe to say most people will have used something that started life on her drawing board, but few will know her name. She worked with engineered fabrics at 3M, designing a moldable bra cup that inspired the design of the N95 mask. Later 3M disputed her role in coming up with the mask. She also worked on clear glass cooktop development, the early microwave, storage systems, and many other products.

The Australian physicist Ruby Payne-Scott helped lay the groundwork for a whole new kind of astronomy: radio astronomy. By scanning the skies for radio waves instead of the light waves we can see with our eyes, Ruby and her colleagues opened a window into the universe and transformed the way we explore it. But to keep her job as a woman working for the Australian government in the 1940s, Ruby had to keep a pretty big secret.

Sallie Pero Mead was first hired at AT&T in 1915 as a “computer”—a human calculator—shortly after completing her master’s degree in mathematics at Columbia University. Before long she started working on the company’s transmission engineering team as both a mathematician and an electrical engineer. She and her team developed and tested hollow metal tubes used as waveguides: structures that confine and direct electromagnetic waves. In 1933 they discovered a new way that hyperfrequency waves could propagate down these tubes, and this made radar technology possible—just in time for use in World War II.

Scientist Leona Zacharias was a rare woman. She graduated from Barnard College in 1927 with a degree in biology, followed by a Ph.D. from Columbia University. But throughout her career she labored behind men with loftier titles who got the bulk of the credit. In the 1940s, when premature babies born with healthy eyes were going blind, Dr. Zacharias was part of the team that worked to root out the cause.

In this best of Lost Women of Science episode, host Katie Hafner visits the archives at M.I.T. and The Massachusetts Eye and Ear Infirmary in Boston to try to understand Dr. Zacharias’s role in rooting out the cause. For host Katie Hafner, it's personal: Leona Zacharias was her grandmother.

Vera Peters began her career studying treatment for Hodgkin lymphoma. She used techniques that had seen positive outcomes on Hodgkin’s to treat breast cancer patients, and she discovered a treatment that was equally effective and much less invasive than the radical mastectomy, saving hundreds of thousands of women from that life-altering surgery.

Annie Montague Alexander was an adventurer, amateur paleontologist, and the founding benefactor of two venerated research collections at UC Berkeley - the UC Museum of Paleontology and the Museum of Vertebrate Zoology. She was born in 1867, the daughter of a wealthy sugar baron, but she never quite fit in with her high society peers. Instead, Annie created for herself a grand life out of doors, away from the constraints of the era: she funded expeditions up and down the West Coast, hunting fossils. And sometimes she wore pants!

But there was a catch. Annie always had to be accompanied by a female chaperone, as it was considered unseemly for a woman to travel surrounded only by men. Luckily, this worked out well for Annie: One of those female chaperones would become her life partner.

For show notes and transcript, visit lostwomenofscience.org

Emma Unson Rotor took leave from her job as a math teacher in the Philippines to study physics at Johns Hopkins University in 1941. Her plans were disrupted when the Imperial Japanese Army invaded and occupied the Philippines. Unable to access her Philippine government scholarship to attend Johns Hopkins, she joined the Ordnance Development Division at the National Bureau of Standards. It was here that she did groundbreaking research on the proximity fuze, the “world’s first ‘smart’ weapon,” in the words of physicist Frank Belknap Baldwin, who also helped develop the technology. 

In 1925, a young anthropologist named Margaret Mead traveled to Samoa to explore the impact of cultural factors on adolescent development. In her subsequent book Coming of Age in Samoa, Mead described teenagers who were free to explore and express their sexuality. The book struck a chord with readers in the U.S., became a bestseller, and Mead skyrocketed to fame. But what were her actual methods and motivations? This episode traces Mead’s legendary nine-month stay in the South Pacific.

Christine Ladd-Franklin is best known for her theory of the evolution of color vision, but her research spanned math, symbolic logic, philosophy, biology, and psychology. Born in Connecticut in 1847, she was clever, sharp-tongued, and never shied away from a battle of wits. When she decided to go to college instead of pursuing a marriage, she convinced her skeptical grandmother by pointing to statistics: there was an excess of women in New England, so a husband would be hard to find; she’d better get an education instead. “Grandma succumbed,” she wrote in her diary. When a man didn't give her credit for her “antilogism,” the core construct in her system of deductive reasoning, she took him to task in print, taking time to praise the beauty of her own concepts. And when Johns Hopkins University attempted to grant Ladd-Franklin an honorary PhD in 1926, she insisted that they grant her the one she'd already earned — after all, she’d completed her dissertation there, without official recognition, more than 40 years earlier. Johns Hopkins succumbed.

There's a test that we at Lost Women of Science seem to fail again and again: the Finkbeiner Test. Named for the science writer, Ann Finkbeiner, the Finkbeiner Test is a checklist for writing profiles of female scientists without being sexist. It includes rules like not mentioning her husband’s job, or her childcare arrangements, or how she was the “first woman to…”—all rules we break regularly on this show. In this episode, Katie Hafner talks to Christie Aschwanden, the science writer who created the test, and Ann Finkbeiner, who inspired it, to find out how they came up with these rules, and to see if there might be hope yet for our series. She reports her findings to Carol Sutton Lewis, who has a whole other set of rules for telling these stories.

Today we tell the story of Mária Telkes, one of the developers of solar thermal storage systems, who was so dedicated to the world of solar energy that while she was working at MIT, she earned the nickname: The Sun Queen. Over her lifetime, she registered more than 20 patents, nearly all related to harnessing the power of the sun. Her inventions included an oven, a desalination device, and one of the first solar-heated houses in 1948: the Dover Sun House. We heard about Mária Telkes from Erin Twamley, a children's book author who shares the stories, careers, and the superpowers of everyday women. She said she would love Dr. Mária Telkes to be in every fifth grade classroom to inspire young people.

In 1856, decades before the term “greenhouse gas” was coined, Eunice Newton Foote demonstrated the greenhouse effect in her home laboratory. She placed a glass cylinder full of carbon dioxide in the sun, and found that it heated up much faster than a cylinder of ordinary air. Her conclusion: more carbon dioxide in the atmosphere results in a warmer planet. Several years later, a British scientist named John Tyndall conducted a far more complicated experiment that demonstrated the same effect and revealed how it worked. Today, he’s widely known as the man who discovered the greenhouse gas effect. There’s even a crater on the moon named for him! Eunice Newton Foote, meanwhile, was lost to history—until an amateur historian stumbled on her story.

Dr. Rebecca Lee Crumpler, born in 1831, was the first African American female medical doctor in the U.S. and is considered the first Black person to publish a medical book. In it, Dr. Crumpler lays out best practices for good health with a focus on women and children. She writes that she was inspired by her aunt, a community healer and midwife, who raised her in Pennsylvania. In 1864, during the Civil War, Rebecca graduated from the New England Female Medical College, the world’s first medical school for women and the founding institution of what is now the Boston University Chobanian & Avedisian School of Medicine. The following year, in the chaotic aftermath of the Civil War, she traveled to Virginia to treat refugees. Many women and children, suddenly freed from bondage, were dying. She worked to dispel the myth that recently freed slaves were spreading disease, rightly pointing instead to poor living conditions. There are no known photos of Rebecca Crumpler, but a Boston newspaper article describes her in her 60s as “tall and straight, with light brown skin and gray hair”. Rebecca Crumpler was ahead of her time, promoting preventive medicine, and she paved the way for women of color in the field of public health.

In the 1960s, a Black home economist at Howard University recruited kids for an experimental preschool program. All were Black and lived in poor neighborhoods around campus.

Flemmie Kittrell had grown up poor herself, just two generations removed from slavery, and she’d seen firsthand the effects of poverty. While Flemmie earned a PhD from Cornell, most of her siblings didn’t make it to college. One of her sisters died at just 22 years old of malnutrition. And it was the combination of these experiences that drove Flemmie to apply her academic training to help improve the lives of people in her community.

In the early 1960s, Flemmie decided to see what would happen if you gave poor kids a boost early in life, in the form of a really great preschool. Every day for two years, parents would get free childcare, and their kids would get comprehensive care for body and mind—with plenty of nutritious food, fun activities, and hugs. What kind of difference would that make? And would it matter later on?

Harriet Jane Lawrence was one of the first female pathologists in the U.S. In the early 1900s she worked in Portland, Oregon, where she hunted microbes and developed vaccines and serum therapies with the help of 200 guinea pigs that she kept in her garage. Her work on a vaccine during the 1918 influenza pandemic earned her presidential recognition and has had a lasting impact on medicine.

Known as “America’s first female cryptanalyst,” Elizebeth Smith Friedman was a master codebreaker who played a pivotal role in both world wars, but for many years, no one knew what she had done—not even her own family.

Elizebeth didn’t set out to be a codebreaker. In 1917, she was a 23-year-old English lit major, looking for an interesting job. That all changed when an eccentric millionaire whisked her off to his lavish country estate and recruited her to work on his passion project: finding the secret codes in Shakespeare’s plays. Elizabeth scoured the texts alongside a tiny team of self-taught codebreakers. No hidden messages surfaced. But soon, the U.S. government came knocking with a slightly higher priority mission. Perhaps her greatest coup was when she uncovered a Nazi spy ring in North America during World War II. J. Edgar Hoover took credit on behalf of the FBI, while Friedman signed an NDA, never speaking of her achievements, and fell into obscurity. Records of what she had done were found in the National Archives annex in College Park, Maryland.

Christine Essenberg had an unusual life and an unusual career trajectory. She was married, then divorced, and earned her PhD in zoology from University of California, Berkeley at age 41. She went on to become one of the early researchers at what is now The Scripps Institution of Oceanography. We know the story of Christine Essenberg only because of a serendipitous find. Host Katie Hafner, searching in an archive jammed with the papers of male scientists, came across a slim folder, "Folder 29", in the back of a box at UC San Diego Special Collections & Archives. Just eight pages as a jumping-off point to flesh out a life, which raises the question: How many other unknown women scientists are out there, hidden away in boxes? This is the story of Christine Essenberg's own journey from researcher to teacher. It’s the first discovery of what we’re calling The Folder 29 Project, a research initiative to uncover the work of lost women of science, hidden in the archives of universities across the country.

Born in 1850, Sarah Loguen found her calling as a child, when she helped her parents and Harriet Tubman bandage the leg of an injured person escaping slavery. When the Civil War ended and Reconstruction opened up opportunities for African Americans, Loguen became one of the first Black women to earn a medical license. But quickly, racist Jim Crow laws prevailed. At the urging of family friend Frederick Douglass, Loguen married and, with her new husband, set sail for the Dominican Republic where more was possible for a person of color. This is her story. 

In the late 1920s, Lillian Gilbreth enlisted her children — she had 11— in an experiment: bake a strawberry shortcake in record time. Kitchens at the time tended to have haphazard configurations—pots and pans could be at one end of the kitchen, the stove in another, and the utensils in another room altogether—but Lillian figured that with a well-designed kitchen, she could slash baking time dramatically and make cooks’ lives easier. And if anyone was going to hack the kitchen, Lillian Gilbreth was the woman for the job.

Lillian and her late husband, Frank, were absolute fiends for efficiency. They’d used the study of “time and motion” to dissect the activities of factory and office workers, and had made a business of optimizing efficiency in the workplace. Now widowed, Lillian Gilbreth, was set to tackle efficiency in the home when their clients would continue working with her and the business failed. Her innovations—she’s widely credited with inventing the pedal trash can and refrigerator door shelves—live with us to this day.

We continue the story of Jewish physicist Lise Meitner, the first person to understand that the atom had been split. This is the second in a two-part series featuring new letters from and to Lise Meitner translated by author Marissa Moss, author of The Woman who Split the Atom: The Life of Lise Meitner (2022). The letters show the fraught and complex relationship between Otto Hahn and Meitner and the role that antisemitism played in the decision to give the Nobel Prize in 1944 to Hahn and not Meitner.

After the discovery of nuclear fission, Meitner grappled with its implication: the advent of nuclear weapons and who would get credit for the discovery of nuclear fission. This would lead to a breakdown of Meitner and Hahn’s decades-long scientific collaboration. Meitner, who had fled Germany because of the Nazis, was horrified at the thought of an atomic bomb. She also faulted Hahn for not speaking out about Nazi atrocities, and questioned his character, though she remained loyal to him to the end. It was their working relationship that defined her life.

New translations of hundreds of letters explain, in a two-part episode of Lost Women of Science, why physicist Lise Meitner was not awarded the Nobel Prize in 1944 for splitting the atom. Instead, it was given to her long-time collaborator, chemist Otto Hahn.

Lise Meitner was born in Vienna in November of 1878 and moved to Berlin before the first World War where she started work with Hahn. When Marissa Moss came to research her biography of Meitner, The Woman who Split the Atom: The Life of Lise Meitner (2022), she found thousands of her letters in the Cambridge University archive, many of which had never been translated.

In this episode we're diving into one particularly illuminating aspect of Meitner's story: her letters with Hahn, which reveal not only that it was Meitner who discovered nuclear fission, when she interpreted experiments that Hahn could not understand, but also her fraught relationship with Hahn. She went to great lengths through her letters to understand his refusal to give her credit for her work before and after the 1944 Nobel Prize was awarded. This first episode takes us up to the end of World War Two.

In the early 1990s, two physicists, Ruth Howes and Caroline Herzenberg, began looking into a question that had aroused their curiosity: Just who were the female scientists who worked on the Manhattan Project?

Nearly ten years and hundreds of interviews later, they documented hundreds of women across a broad spectrum of scientific fields — physics, chemistry, biology, mathematics — who played crucial roles in the top-secret race to build a nuclear weapon that would end World War II.

Since the film Oppenheimer came out earlier this summer, Their Day in the Sun: Women of the Manhattan Project has enjoyed a revival of sorts as new attention is paid to the women for whom recognition is long overdue.

Katharine “Kay” Way was a nuclear physicist who worked at multiple Manhattan Project sites. She was an expert in radioactive decay. But after the atomic bombs were dropped on Japan, she became increasingly concerned about the ethics of the nuclear weapons. Dr. Way signed the Szilard Petition and  worked to spread awareness of the moral responsibility surrounding atomic weaponry, including co-editing the influential One World or None: a Report to the Public on the Full Meaning of the Atomic Bomb, remaining an outspoken advocate for fairness and justice.

Lilli Hornig was only 23 years old when she arrived at Los Alamos to contribute to the development of an atomic bomb that would end World War II. A talented chemist, Lilli battled sexism throughout her career and remained a steadfast advocate for female scientists like herself.

Lilli is the only female scientist named in Christopher Nolan’s film Oppenheimer. But the character is a blur, popping up here and there to say they didn’t teach typing in her graduate chemistry program at Harvard, when asked whether she could be a typist, or to rib a colleague, telling him that her reproductive system was better protected from radiation than his. The real Hornig worked closely on plutonium research and was part of the team that developed and tested the mechanism for the plutonium weapon in the Trinity test.

Naomi Livesay, born in 1916 in the northern reaches of Montana, aspired to one career: mathematics. She earned a bachelor’s degree in math, but when she decided to pursue a Ph.D. at the University of Wisconsin, men on the faculty balked. Mathematics, they said, was no place for a woman.

Then fate intervened, and Livesay embarked on a circuitous route to Los Alamos, where she landed in 1944 and started as a supervisor in the computation lab during the Manhattan Project. She played, as episode guest Nichole Dale Lewis describes it, “a unique role at a unique place under unique pressures.”

Livesay was a reluctant recruit, and it wasn’t until the physicist Richard Feynman stepped in to persuade her to take the job of supervising work on the IBM punch card accounting machinery, that she agreed. And then Oppenheimer himself went out of his way to make sure that Livesay had everything she needed to get the job done.

Floy Agnes Lee was a hematologist at Los Alamos. Recruited to the Manhattan Project while still  a student at University of New Mexico, she collected blood samples from many Manhattan Project scientists, including Louis Slotin, following an accident that exposed him to a fatal dose of radiation. Years after the war, she returned to Los Alamos National Laboratory and conducted research on the impact of radiation on chromosomes.

Leona Woods Marshall Libby was the only woman hired onto Enrico Fermi's team at the Metallurgical Laboratory at the University of Chicago. She was just 23 years old, already had a Ph.D. in molecular spectroscopy and a deep understanding  of vacuum technology. She was also the only woman present at the world’s first successful nuclear chain reaction. Amid all this, she managed to conceal her pregnancy until two days before her baby was born.

During World War II, thousands of scientists and engineers worked on the Manhattan project, the top secret push to develop an atomic bomb that would end the war. Two bombs dropped on Hiroshima and Nagasaki did just that, while also killing hundreds of thousands of Japanese civilians. The devastating potential of nuclear weapons sparked a moral controversy that continues to this day.

Hundreds of the scientists who worked on the Manhattan Project were women. Over the next few weeks we’ll be bringing you a few of their stories.

Welcome to the first in our From Our Inbox series, in which we give listeners a taste of the mail we get from folks wanting to bring a particular forgotten scientist to our attention. Here’s the story of Alessandra Giliani, brought to us by Barbara Quick, an author and poet in the San Francisco Bay Area.

There’s a persistent myth in the Emilia-Romagna region of Italy about Alessandra Giliani, a 14th-century girl who defied the laws of Church and state to attend medical school. The most concrete evidence of her existence comes in the form of illuminated manuscripts depicting an assistant to anatomist Mondino de Liuzzi who appears to be a cross-dressed woman. In this episode, associate producer Mackenzie Tatananni speaks with author Barbara Quick about Alessandra’s discoveries, which were well ahead of their time.

Cecilia Payne was in her early 20s when she figured out what the stars are made of. Both she and her groundbreaking findings were ahead of their time. Continuing the legacy of women working at the Harvard Observatory, Cecilia charted the way for a generation of female astronomers to come. This episode of Lost Women of Science: shorts follows Cecilia’s journey of discovery, journals her drive and determination against all odds, and takes you to the Harvard Observatory itself to walk in Cecilia’s footsteps.

In 1992, a Dutch doctor named Josh von Soer Clemm von Hohenberg wrote a letter to Henning Voscherau, the mayor of Hamburg, Germany, requesting that a street be named after Marie Nyswander.

The doctor had never met Marie, but he had founded a clinic for treating people with drug addiction, and he’d seen methadone treatment — co-developed by Marie — save lives. Four years later, doctors gathered on a street in northwest Hamburg to celebrate that street’s new name: Nyswanderweg. We’re investigating how German streets get their names, and why so few of them honor women like Marie, who have made historic achievements.

Marie Nyswander died in 1986. She’d achieved almost everything she set out to, but she wanted more: even better medications than methadone, fewer regulations, and the holy grail—a cure for addiction. Addiction science has come a long way since Marie’s time, and it turns out, a lot of the field’s earlier assumptions were probably wrong. Neuroscientist Kent Berridge explains why wanting something isn’t the same as liking it. But a cure is still out of our reach

A reminder that our next episode is scheduled to come out next Thursday!

In the meantime, we’ve hit a slight snag—Katie has COVID—but she’s resting up, and we’re doing our best to get that episode to you on time. Stay tuned for updates. We'll be back very soon.

Marie Nyswander and her team at Rockefeller unveil their findings at last: methadone has utterly transformed their patients. They’re going back to school, getting jobs, and reconnecting with family and friends. One of the very first patients went onto college and graduated with a degree in aeronautical engineering, all while taking methadone. But soon, Marie’s treatment starts getting resistance, from fellow doctors as well as patients, who think what she’s doing is immoral.

See show notes and full transcripts at lostwomenofscience.org

After years of disappointing results in her quest to treat heroin addiction, Marie Nyswander was more than ready to try something new. When she met a prominent doctor from the prestigious Rockefeller Institute, they embarked on an experiment that would define both of their careers and revolutionize the treatment of addiction for decades to come. But not everyone was happy about it.

In the early 1950s, Marie Nyswander was ready to move on from addiction. She set up a private practice and specialized in treating women afflicted with what she would call one of the “gravest problems of our time”: sexual frigidity. She and her adoring husband were living the good life, hanging out with rich art collectors and members of the New York literary scene. But when Marie started getting phone calls for help, she got pulled in a very different direction.

Show notes and episode transcripts are available at lostwomenofscience.org

In 1946, Marie Nyswander, a recent medical school graduate, joined the U.S. Public Health Service looking for adventure abroad. Instead, they sent her to Lexington, Kentucky’s Narcotic Farm, a prison and rehabilitation facility for people with drug addiction, where therapies included milking cows and basket-making. It was at Lexington that Marie encountered addiction for the first time, and what she saw there disturbed her—and reset her life’s course.

For show notes and episode transcripts, visit lostwomenofscience.org

In 1965, a team of doctors at Rockefeller University announced what sounded like a miracle—they’d found a treatment for heroin addiction that actually seemed to work.

For nearly two years, the researchers had been running an experiment with a small group of men, aged 19 to 37, who’d been using heroin for several years—and the results were astonishing. Men who’d been transfixed by heroin cravings for years, who had tried to quit before and failed, were suddenly able to return to their lives. One started painting. Another finished high school and got a scholarship to go to college. 

The key to these transformations was a drug called methadone. But the treatment was controversial, and one of the doctors on the team already had a bit of a reputation as a bold, and possibly even reckless, defier of convention: Marie Nyswander.

This season, we bring you her story and the radical treatment that would upend the landscape of addiction for decades to come.

In 1909, the Mayor of Tokyo sent a gift of 2,000 prized cherry trees to Washington, D.C. But the iconic blossoms enjoyed each spring along the Tidal Basin are not from those trees. That’s because Flora Patterson, who was the Mycologist in Charge at the USDA, recognized the original saplings were infected, and the shipment was burned on the National Mall. In this episode, assistant producer Hilda Gitchell explores Flora’s lasting impact on the field of mycology, starting with a blight that killed off the American chestnut trees, and how she helped make the USDA’s National Fungus Collection the largest in the world.

Scientist Leona Zacharias was a rare woman. She graduated from Barnard College in 1927 with a degree in biology, followed by a Ph.D. from Columbia University. But throughout her career she labored behind men with loftier titles who got the bulk of the credit. In the 1940s, when premature newborns were going blind after being born with perfectly healthy eyes, Dr. Zacharias was part of the team that worked to root out the cause.

In this inaugural episode of Lost Women of Science Shorts, host Katie Hafner visits the archives at M.I.T. and The Massachusetts Eye and Ear Infirmary in Boston to try to understand Dr. Zacharias’s role in rooting out the cause.For host Katie Hafner, it's personal: Leona Zacharias was her grandmother.

Each season of Lost Women of Science tells the story of one remarkable female scientist, but hundreds more remain overlooked. That’s why we’re introducing Shorts—each 30-minute episode tells the remarkable story of a scientific breakthrough and the woman who played a crucial role in it. Join us as we launch Shorts on January 12th.

We’re hard at work producing the next season of Lost Women of Science, but we wanted to bring you this special guest episode from Portraits, a podcast from the Smithsonian’s National Portrait Gallery. Dr. Chien-Shiung Wu was a towering figure in science whose parity experiment shattered our understanding of the physical world. She enjoyed rockstar status in China, met the pope, inspired an opera and even became a “Jeopardy!” question. But to Jada Yuan, she was grandma.

See the portraits discussed in the episode:

Dr. Wu in the lab

Tsung-Dao Lee, Nobel Laureate

Chen-Ning Yang, Nobel Laureate

Dr. Wu on the forever stamp

Also, check out Jada Yuan’s article about her grandmother here!

There's a test that we at Lost Women of Science seem to fail again and again: the Finkbeiner Test. Named for the science writer, Ann Finkbeiner, the Finkbeiner Test is a checklist for writing profiles of female scientists without being sexist. It includes rules like not mentioning her husband’s job, or her childcare arrangements, or how she was the “first woman to…”—all rules we break regularly on this show. In this episode, Katie Hafner talks to Christie Aschwanden, the science writer who created the test, and Ann Finkbeiner, who inspired it, to find out how they came up with these rules, and to see if there might be hope yet for our series. She reports her findings to Carol Sutton Lewis, who has a whole other set of rules for telling these stories.

This week, we’re bringing you an episode from another podcast hosted and produced by Katie Hafner, Our Mothers Ourselves. It’s a show that celebrates extraordinary mothers through conversations with their children. In this episode, Katie speaks with Yvonne Young Clark’s daughter, Carol Lawson.

We hope you enjoy this episode of Our Mothers Ourselves, “The ‘Relentlessly Positive’ Yvonne Young Clark: An Interview with Y.Y.'s Daughter, Carol Lawson.”

YY taught at Tennessee State University, a historically Black university, for 55 years. In this episode, we hear from YY’s colleagues, students and family members about who she was as an educator and how she’s remembered. We’ll also explore where HBCUs stand today – particularly, why they graduate so many successful Black scientists compared to other institutions, and their place in the future of science. Plus, a reimagining of YY’s accomplishments: what did it mean to be the first?

Access a transcript of the episode here: https://www.scientificamerican.com/article/this-black-female-engineer-broke-through-the-double-bind-of-racism-and-sexism-and-directly-nurtured-a-legion-of-stem-leaders/

What is mechanical engineering? What was YY actually doing? This episode is about the work itself – specifically, the work Yvonne Young Clark did at NASA on the Saturn V rocket, and in designing the “moon rock box” for transporting lunar samples back to Earth. And we take a deep dive into the history of the American space program, the mechanics of a rocket, and how YY brought her troubleshooter’s mind to a problem that was plaguing some of the country’s top scientists.

Access a transcript of the episode here: https://www.scientificamerican.com/article/nasas-saturn-v-rocket-the-moon-rock-box-and-the-woman-who-made-them-work-properly/

When YY started college at Howard University as a mechanical engineering student, there were three things she swore she’d never do: marry a tall man, become a teacher, and work for the government. But love and life had other plans, and YY soon discovered the difficulty of entering private industry as one of the few Black women in her field. After success at RCA-Victor and Frankford Arsenal, YY moved back to the South, where Brown v. Board of Education had recently integrated public schools, prompting a violent backlash.

Access a transcript of the episode here: https://www.scientificamerican.com/article/for-the-first-lady-of-engineering-freedom-meant-facing-down-racism-and-sexism-and-breaking-her-own-rules/

With a librarian mother and a physician father, YY was brought up in a supportive, educated, and prosperous Black enclave of Louisville, Kentucky. Her parents nurtured her knack for engineering. She got her start as a young child when she repaired the family toaster. An early introduction to a Black pilot group inspired her to fly planes, and she applied to the University of Louisville, where she hoped to study engineering and eventually aeronautics—until she learned her race disqualified her.

Access a transcript of the episode here: https://www.scientificamerican.com/article/the-first-lady-of-engineering-lost-women-of-science-podcast-season-3-episode-1/

Yvonne Y. Clark, known as YY throughout her career, has also been nicknamed “The First Lady of Engineering,” because of her groundbreaking achievements as a Black female mechanical engineer. Season 3 of Lost Women of Science traces her trajectory, from her unconventional childhood interest in fixing appliances to civil rights breakthroughs in the segregated South; from her trailblazing role at historically Black colleges and universities to her work at NASA. What can YY teach us about what it means to be the first in a scientific field, especially as a Black woman in America?

Carol Sutton Lewis, host of the podcast Ground Control Parenting, has long been interested in Black history. This season, she’s joining Lost Women of Science as a cohost to help tell the story of the mechanical engineer, Yvonne Young Clark. Known as Professor Clark to her students and YY to her engineering colleagues, YY’s career spanned academia and industry. She was a dedicated STEM educator and a champion of historically Black colleges and universities. Alongside cohost Katie Hafner, Carol will trace YY’s life and work through fascinating chapters of Black history, from the promises of Reconstruction to integration efforts at NASA.

We saw the story over and over again: computer programmer Klára Dán von Neumann was a pioneer in weather forecasting. But when we talked to Thomas Haigh, a historian who studies Klári’s work, he said he’s found absolutely no evidence of this. How did this weather myth start? We set out to answer that question, and in the process, we asked this: Why is it so tempting to credit the wrong person, even when that false credit is given with the best of intentions?

Note: we’d like to acknowledge the operators of the ENIAC who ran the 1950 weather simulation, Homé McAllister and Clyde Hauff.

Access a transcript of the episode here: https://www.scientificamerican.com/article/the-weather-myth-lost-women-of-science-podcast-season-2-bonus-episode/

After Johnny’s death, Klári becomes the keeper of his legacy. It’s an exhausting, full-time commitment that takes her out of the computing world for good. She marries her fourth husband, a physicist, and moves to a Southern California beach town. She resolves to settle down, and starts writing a memoir. We discuss her legacy in computing and beyond, and the current state of gender and programming.

Note: this episode includes content that could be upsetting. We’ll be talking about depression and self-harm.


Access a transcript of the episode here.

After World War II, tensions build between the Soviet Union and the U.S. Scientists at Los Alamos continue developing nuclear weapons, helped by the recently-reconfigured ENIAC. Using a statistical method called Monte Carlo, they optimize nuclear weapons through computer simulations. In these simulations, physics is neither purely experimental nor theoretical–it’s both, creating what historian Peter Galison calls a “netherland…at once nowhere and everywhere.” And Klári finds herself immersed in this sort of netherworld, turning nuclear physics into code.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-4-netherworld/

When John von Neumann runs into fellow mathematician Herman Goldstine at a train station, Goldstine clues him into a new powerful computer called the ENIAC that is being constructed to help with the war effort, and Johnny immediately grasps the machine’s enormous potential. Though the computer is not completed in time to be useful in the second world war, it finds new purpose in the war’s aftermath. Soon, Klári von Neumann is enlisted to instruct the machine what to do, and in doing so, becomes one of the first coders. This episode takes a deep dive into the workings of the ENIAC and the origins of computing in the 1940s.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-3-the-experimental-rabbit/

With John von Neumann absorbed in work, Klári struggles to find a niche in her new suburban home while dealing with devastating losses. A new chapter opens for Klári when the U.S. finally enters the war and women are called into the workforce.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-two-women-needed/

To understand how Klára Dán von Neumann arrived at computer programming, we need to first understand where she came from. Born in Budapest to a wealthy Jewish family, Klári grew up surrounded by artists, playwrights, and intellectuals. Her first marriage, to an inveterate gambler, took her on a tour of Europe’s casinos, and in one of them, she had a chance encounter with the famous mathematician, John von Neumann.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-one-the-grasshopper/

The first modern-style code executed on a computer was written in the 1940s by a woman named Klára Dán von Neumann–or Klári to her family and friends. And the historic program she wrote was used to optimize nuclear weapons. This season, we dive into this fascinating moment in postwar America through Klári’s work. We explore the evolution of early computers, the vital role women played in early programming, and the inescapable connection between computing and war.

In 1949, at the height of his career, Rustin McIntosh, the director of pediatrics at Columbia University’s Babies Hospital, submitted his letter of resignation. Dr. Scott Baird, who wrote a biography on Dorothy Andersen, takes us back to this pivotal moment, which occurred at the dawn of pediatric pathology in the United States. Through archival resources, Scott explores the institutional tensions that led to this abrupt resignation. At the eye of the storm is a character we’ve come to know well, perhaps the most important person working in pediatric pathology at the time: Dr. Dorothy Andersen.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-bonus-episode-the-resignation/

In our final episode, we explore Dorothy Andersen’s legacy—what she left behind and how her work has lived on since her death. Describing her mentor’s influence on her life and career, Dr. Celia Ores gives us a rare look into what Dr. Andersen was really like. We then turn to researchers, doctors, and patients, who fill us in on the progress that has grown from Dr. Andersen’s initial work. These major developments include the discovery of the cystic fibrosis gene, the tremendous impact of the drug Trikafta, and the lifesaving potential of gene editing techniques.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-4-breakfast-in-the-snow/

A missing portrait of Dr. Andersen takes us on a journey into the perils of memorialization—and who gets to be remembered. Dr. Scott Baird hunts for the portrait, and Drs. Nientara Anderson and Lizzy Fitzsousa, former medical students at Yale, explain how, in today’s diverse communities, “dude walls” can have an insidious effect on those who walk past them every day.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-3-the-case-of-the-missing-portrait/

A passionate outdoorswoman, a “rugged individualist,” and a bit of an enigma—the few traces Dr. Andersen left behind give us glimpses into who she was. In this episode, we track down people determined to stitch together her life. Our associate producer, Sophie McNulty, rummages through the basement of Dr. Andersen’s colleague for clues about the elusive pathologist. Meanwhile, in Manhattan, pediatric intensivist Scott Baird suggests we take a second look at the conventional wisdom surrounding the evolution of cystic fibrosis research in the 1950s.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-2-the-matilda-effect/

When Dr. Dorothy Andersen confronted a slew of confounding infant deaths, she suspected the accepted diagnosis wasn’t right. Her medical sleuthing led to the world’s understanding of cystic fibrosis, a disease that affects the lungs, the pancreas, and a host of other organs. But hers is by no means a household name. Who was this scientist, and how did she come to quietly make such an important medical contribution?

Access a transcript of the episode here: https://www.scientificamerican.com/article/the-lost-women-of-science-episode-1-the-question-mark/

When Dr. Dorothy Andersen confronted a slew of confounding infant deaths, she knew the accepted diagnosis couldn’t be right. Her medical detective work led to our current understanding of Cystic Fibrosis, a disease that circuitously impacts the pancreas and lungs. But she is by no means a household name, and the details of her life get scarcer every day. Who was this scientist, and how did she come to quietly make such an important medical contribution?

For every Marie Curie or Rosalind Franklin whose story has been told, hundreds of female scientists remain unknown to the public at large. We illuminate the lives and work of a diverse array of groundbreaking scientists who, because of time, place and gender, have gone largely unrecognized. Each season focuses on one scientist, putting her narrative into context, explaining not just the science but also the social and historical conditions in which she lived and worked. We also bring these stories to the present, painting a full picture of how her work endures.