Medscape InDiscussion: Psoriasis

Drs Steve Feldman and Megan Noe fill in the gaps about pustular psoriasis, a relatively rare but serious condition that can be tough to diagnose.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986155). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Palmoplantar Pustulosis: Current Understanding of Disease Definition and Pathomechanism https://pubmed.ncbi.nlm.nih.gov/32201085/

Evaluation of a Case Series of Patients With Generalized Pustular Psoriasis in the United States https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655659/

Pathophysiology of Generalized Pustular Psoriasis https://pubmed.ncbi.nlm.nih.gov/36779688/

Trial of Spesolimab for Generalized Pustular Psoriasis https://pubmed.ncbi.nlm.nih.gov/34936739/

Drs Steve Feldman and Andrew Blauvelt have a fascinating chat about contrasts and similarities between biologics and biosimilars, covering pharmacoeconomic and legal differences between the US and Europe.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986154). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Biosimilar Drugs for Psoriasis: Principles, Present, and Near Future https://pubmed.ncbi.nlm.nih.gov/29549597/

International Psoriasis Council https://psoriasiscouncil.org/

Biosimilars for Psoriasis: Clinical Studies to Determine Similarity https://pubmed.ncbi.nlm.nih.gov/27639072/

Safety, Efficacy and Drug Survival of Biologics and Biosimilars for Moderate-to-severe Plaque Psoriasis https://pubmed.ncbi.nlm.nih.gov/29094341/

Dr Steven R. Feldman and nurse practitioner Lakshi M. Aldredge discuss systemic therapy for psoriasis and how nurse practitioners and physician associates fill an important gap.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986153). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199465/?report=reader

Tumor Necrosis Factor Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK482425/

Deucravacitinib for the Treatment of Psoriatic Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372960/

Drs Steven R. Feldman and Kim A. Papp discuss the expanding universe of opportunities and advances for halting limited psoriasis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986152). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Trial of Roflumilast Cream for Chronic Plaque Psoriasis https://pubmed.ncbi.nlm.nih.gov/32668113/

Psoriasis in Special Localizations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330687/

Vitamin D Analogs in the Treatment of Psoriasis: Where Are We Standing and Where Will We Be Going? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219168/

Dr Steve Feldman speaks with Drs Mehta, Ritchlin, and Fried who share an exciting new roadmap for calming key psoriasis comorbidities.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986151). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Treatment of Psoriasis With Biologic Therapy Is Associated With Improvement of Coronary Artery Plaque Lipid-rich Necrotic Core: Results From a Prospective, Observational Study https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.120.011199

Treating the Skin With Biologics in Patients With Psoriasis Decreases the Incidence of Psoriatic Arthritis https://pubmed.ncbi.nlm.nih.gov/34281904/

The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener https://pubmed.ncbi.nlm.nih.gov/14583691/

Dr Steven Feldman and Leah Howard, National Psoriasis Foundation President and CEO, discuss how an unseen and unheard patient population has begun to step out and speak up — at the US Capitol and beyond.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986130). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

National Psoriasis Foundation (NPF) https://www.psoriasis.org/

Management of Psoriasis as a Systemic Disease: What Is the Evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187293/

Psoriasis: Classical and Emerging Comorbidities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323693/

Host Dr Steven Feldman unpacks years of accrued knowledge on managing psoriasis using biologic therapy, with our special guest Dr Craig Leonardi.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/965167). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Joint AAD-NPF Guidelines of Care for the Management and Treatment of Psoriasis With Biologics https://www.jaad.org/article/S0190-9622(18)33001-9/fulltext

Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review https://pubmed.ncbi.nlm.nih.gov/32121574/

Biologic Treatments of Psoriasis: An Update for the Clinician https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896737/

This podcast has the goods on what oral therapy to recommend for almost any circumstance, even weddings. Drs Steven Feldman and Bruce Strober share a treasure trove of practical wisdom.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/965165). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Acitretin Revisited in the Era of Biologics https://pubmed.ncbi.nlm.nih.gov/20673152/

Combining Biologic Therapies With Other Systemic Treatments in Psoriasis: Evidence-Based, Best-Practice Recommendations From the Medical Board of the National Psoriasis Foundation https://jamanetwork.com/journals/jamadermatology/article-abstract/2019961

Joint American Academy of Dermatology–National Psoriasis Foundation Guidelines of Care for the Management of Psoriasis with Systemic Nonbiologic Therapies https://www.jaad.org/article/S0190-9622(20)30284-X/fulltext

Dr Joel Gelfand talks with host Dr Steven Feldman about why phototherapy is a great tool for treating psoriasis. He shares insights on who can benefit and how to approach patients about it.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965163). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Plaque Psoriasis Treatment & Management https://emedicine.medscape.com/article/1108072-treatment#d11

Effect of UV-B Phototherapy on Plasma HIV Type 1 RNA Viral Level: A Self-Controlled Prospective Study https://jamanetwork.com/journals/jamadermatology/fullarticle/189280

Effect of Two Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991103/

Dermatologists Steven Feldman and Melinda Gooderham share expert advice and go-to options for topical use in patients with psoriasis.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965162). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Joint AAD–NPF Guidelines of Care for the Management and Treatment of Psoriasis With Topical Therapy and Alternative Medicine Modalities for Psoriasis Severity Measures https://www.jaad.org/article/S0190-9622(20)32288-X/fulltext#secsectitle0050

Does the Vehicle Matter? Real-World Evidence on Adherence to Topical Treatment in Psoriasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539972/

Optimizing the Use of Topical Agents in Psoriasis https://www.scmsjournal.com/wp-content/uploads/2017/02/v33i2s-Optimizing-the-use-of-Topical-Agents.pdf

What's the best way to screen for common comorbidities in patients with psoriasis, and how do the experts respond when clues of systemic disease show up?

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965161). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

Psoriasis https://emedicine.medscape.com/article/1943419-overview#a6

Axial Psoriatic Arthritis: An Update for Dermatologists https://www.jaad.org/article/S0190-9622(20)30959-2/fulltext

Psoriatic Arthritis https://emedicine.medscape.com/article/2196539-overview

Psoriatic Arthritis: State of the Art Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297592/pdf/clinmed-17-1-65.pdf

Joint American Academy of Dermatology–National Psoriasis Foundation Guidelines of Care for the Management of Psoriasis With Systemic Nonbiologic Therapies https://www.jaad.org/article/S0190-9622(20)30284-X/fulltext

Axial Spondyloarthritis https://ard.bmj.com/content/80/12/1511.long

Use of IL-23 Inhibitors for the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727454/pdf/40257_2020_Article_578.pdf

Risankizumab, an IL-23 inhibitor, for Ankylosing Spondylitis: Results of a Randomized, Double-blind, Placebo-Controlled, Proof-of-concept, Dose-Finding Phase 2 Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104676/pdf/annrheumdis-2018-213328.pdf

Axial Involvement in Psoriatic Arthritis Cohort (AXIS): The Protocol of a Joint Project of the Assessment of SpondyloArthritis International Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721378/pdf/10.1177_1759720X211057975.pdf

Three Multicenter, Randomized, Double-blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis https://onlinelibrary.wiley.com/doi/10.1002/art.40728

Efficacy of Guselkumab on Axial Involvement in Patients With Active Psoriatic Arthritis and Sacroiliitis: A Post-Hoc Analysis of the Phase 3 DISCOVER-1 and DISCOVER-2 Studies https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(21)00105-3/fulltext

Efficacy and Safety of Ustekinumab in Psoriatic Arthritis Patients With Peripheral Arthritis and Physician-Reported Spondylitis: Post-hoc Analyses From Two Phase III, Multicentre, Double-blind, Placebo-Controlled Studies (PSUMMIT-1/PSUMMIT-2) https://ard.bmj.com/content/75/11/1984.long

BASDAI Calculator https://qxmd.com/calculate/calculator_299/basdai

Effectiveness, Costs and Cost-effectiveness of Chiropractic Care and Physiotherapy Compared With Information and Advice in the Treatment of Non-specific Chronic Low Back Pain: Study Protocol for a Randomised Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741874/pdf/13063_2017_Article_2351.pdf

Axial Involvement in Psoriatic Arthritis: An Update for Rheumatologists https://www.sciencedirect.com/science/article/pii/S0049017221001190?via%3Dihub

Dactylitis: A Hallmark of Psoriatic Arthritis https://www.sciencedirect.com/science/article/pii/S0049017217306261?via%3Dihub

Psoriasis Workup https://emedicine.medscape.com/article/1943419-workup#c2

Treatment Guidelines in Psoriatic Arthritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065461/pdf/kez383.pdf

Risk of Myocardial Infarction in Patients With Psoriasis https://jamanetwork.com/journals/jama/fullarticle/203598

Cardiovascular Disease Prevention for Psoriasis and Psoriatic Arthritis (CP3) https://www.med.upenn.edu/gelfand/research.html

Primary Care-Based Screening for Cardiovascular Risk Factors in Patients With Psoriasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113692/pdf/BJD-175-348.pdf

Psoriasis: Comorbidities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252780/pdf/JDE-48-732.pdf

Changing Health Behaviours in Rheumatology: An Introduction to Behavioural Economics https://www.nature.com/articles/s41584-019-0336-1

The Influence of Body Weight of Patients With Chronic Plaque Psoriasis on Biological Treatment Response https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262805/

What drives patients with psoriasis to seek care? Dr Steven Feldman and Professor Andrew Finlay, inventor of the Dermatology Life Quality Index, explore what matters most to patients.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/965160). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

How is the severity of psoriatic arthritis and psoriasis usually assessed? https://www.medscape.com/answers/2196539-155443/how-is-the-severity-of-psoriatic-arthritis-and-psoriasis-is-usually-assessed

Dermatology Life Quality Index (DLQI) https://www.bad.org.uk/shared/get-file.ashx?id=1653&itemtype=document

Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2230.1994.tb01167.x

Determining the Minimal Clinically Important Difference and Responsiveness of the Dermatology Life Quality Index (DLQI): Further Data https://www.karger.com/Article/FullText/365390

A Changed Life: The Life Experiences of Patients With Psoriasis Receiving Biological Treatment https://onlinelibrary.wiley.com/doi/10.1111/bjd.18876

Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): The Correlation Between Disease Severity and Psychological Burden in Patients Treated With Biological Therapies https://pubmed.ncbi.nlm.nih.gov/23425140/