Biochemistry & Molecular Biology of Serotonin Receptors, Tryptamines & Psychedelics | Ryan Gumpper | 102

Send us a text

Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds with therapeutic benefits, as well as the inspiration Ryan received from reading Alexander Shulgin's famous book, PIHKAL.

*Not medical advice.

Support the show

All episodes, show notes, transcripts, etc. at the M&M Substack

Affiliates:

• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Readwise: Organize and share what you read. Use your phone's link.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.
• KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription.
• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off.

For all the ways you can support my efforts