1347 avsnitt • Längd: 20 min • Veckovis: Torsdag
Your One Stop Shop For All Things Self-Improvement Related
The podcast More Plates More Dates is created by Derek. The podcast and the artwork on this page are embedded on this page using the public podcast feed (RSS).
📌 Check out the full podcast here: https://youtu.be/E0mudvCm-bo
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
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📌 Check out the full podcast here: https://youtu.be/E0mudvCm-bo
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📌 Check out the full podcast here: https://youtu.be/_PG6sLMuWS8
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📌 Sponsors To Check Out:
🛌 Eight Sleep - Code "MPMD" will save $200 off the Pod 4, or $350 off the Pod 4 Ultra: https://www.eightsleep.com/moreplatesmoredates/
⚕️ Marek Health - Preventive Medicine, HRT, & Rigorous Bloodwork Analysis: https://bit.ly/373k791
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🕑 Timestamps:
0:00:00 – Intro
0:00:57 – The ‘Rejuvenation Olympics’ Leaderboard
0:02:47 – Who Is Bryan Johnson?
0:09:05 – How Bryan Transitioned From Near-Billionaire Tech Entrepreneur To Experimental Biohacker
0:13:07 – Why Bryan Johnson's Johnson Is The Most Measured Johnson On Earth
0:18:14 – Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used)
0:21:56 – Erection Quality Metrics And Issues With Tracking
0:23:36 – The Exotic Drugs In Bryan Johnson's "Don't Die" Protocol
0:27:34 – "Don't Die" (but take experimental drugs?) | Grilling Bryan Johnson On His Choice Of Drugs
0:30:58 – Bryan’s View On Hair Transplants, Facial Fillers, Plastic Surgery, Or Anything Surgical That Conflates The Visual Perception Of A Person’s Age
0:33:40 – "HGH Was Catastrophic" | Bryan’s Experience With HGH And Thymus Rejuvenation
0:36:52 – Rapamycin For ‘Anti-Aging’
0:40:23 – Why Bryan Tried Follistatin Gene Therapy, IV Stem Cells, And Is Using 17α-Estradiol And Metformin
0:45:13 – Power Outage
0:45:14 – Bryan Johnson Risks Ruining His Perfect Sleep Score To Try A Gorilla Mind Energy Drink
0:49:22 – Dissecting The Results Of Bryan Johnson's $25,000 Follistatin Gene Therapy
1:06:38 – What Is Bryan’s ‘Blueprint’ Protocol?
1:15:33 – Bryan Reacts To Elon Musk Saying He Looked Better Before
1:23:54 – Bryan Reacts To Chuando Tan (58 years old) - Does Biohacking Even Work?
1:30:15 – How To Become A Centenarian (100+ Years Old)
1:32:59 – The Most Impactful Of The Exotic Biohacks Bryan Has Tried
1:39:59 – Why Bryan Went On TRT, And Then Came Off
1:44:54 – Does Bryan Have Financial Upside In Any Of The Companies He Promotes That He Hasn’t Explicitly Stated Are His Companies?
1:46:26 – Why 15% Of Bryan’s Daily Calories Come From Extra Virgin Olive Oil (EVOO)
1:48:43 – Diary Of A CEO Podcast Quote About EVOO | “It’s Better Than Ozempic”
1:57:52 – Bryan Psychoanalyzes Me
2:07:11 – Marek Health (Preventive Medicine, HRT, & Rigorous Bloodwork Analysis)
2:13:37 – Bryan Dissects My Mindset
2:16:15 – Determining What Content Creators To Learn From
2:19:11 – The Understanding Of Myostatin Inhibiting Muscle Growth Over The Years
2:22:32 – The Challenges Of Being A Night Owl And Not Sleeping Enough
2:26:01 – Chasing Success, Even When It Starts To Eat Into The Rest Of Your Life
2:32:52 – Imposter Syndrome
2:35:27 – If I Could Change One Thing About How The Medical System Works
2:38:37 – Influencer Burnout
2:40:10 – My Ancestry And Nature Vs. Nurture
2:44:37 – Jordan Peterson's Opinion Of Bryan Johnson’s Life Philosophy
2:53:13 – Thoroughly Dissecting Bryan’s New Supplement Line, His Motivations Behind Starting It, And His Claims Made About Its Efficacy
3:34:36 – Bryan Stating On Diary Of A CEO That Everybody Should Know Their Weight, Speed Of Aging, And Duration Of Nighttime Erections
3:36:33 – The Legitimacy And Utility Of Age Clocks, And When They Can Be Helpful Vs. Harmful
3:58:52 – Bryan’s Use Of Thyroid Hormone Replacement Since He Was 21 Years Old
4:01:14 – Is Drinking Your Own Urine A Dark Horse Biohack? Bryan’s Reaction
4:04:03 – If Bryan Could Go Back In Time Before He Sold His Company For $800 Million, What Would He Tell Himself
4:08:45 – How Does Bryan Factor In Social Loneliness Outranking Essentially Everything For Accelerating Dying
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📌 Sponsors To Check Out:
🛌 Eight Sleep - Code "MPMD" will save $200 off the Pod 4, or $350 off the Pod 4 Ultra: https://www.eightsleep.com/moreplatesmoredates/
⚕️ Marek Health - Preventive Medicine, HRT, & Rigorous Blood Work: https://bit.ly/373k791
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
————————————
🕑 Timestamps:
0:00:00 - 0:13:37 – Epigenetics, Methylation, And Aging
0:13:37 - 0:19:02 – Books That Have Dramatically Impacted Peter’s Life. His Current Career Goals.
0:19:02 - 0:22:42 – Sponsor: Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used)
0:22:44 - 0:29:50 – AI, And Why Peter Typically Doesn’t Find Tests That Look For Early ASCVD Valuable
0:29:50 - 0:32:12 – Is There An APOB Level That Guarantees No Risk Of Atherosclerosis?
0:32:12 - 0:33:27 – For Those With Hypofunctioning PCSK9 And Extremely Low LDL-C, What Is Their Average Age Of Death, And What Are They Dying From?
0:33:27 - 0:35:06 – How Much Cholesterol Is Needed For Brain Development?
0:35:06 - 0:36:22 – How Lipid Managing Medications Work
0:36:22 - 0:41:16 – How Peter Evaluates The Best Strategy For Managing APOB For Each Patient
0:41:16 - 0:42:39 – Can You Trust Grocery Store Olive Oil?
0:42:39 - 0:44:09 – Is Olive Oil Healthier Than Eating Less?
0:44:09 - 0:47:56 – If You’re Thriving With Bad Lipids, What Should You Do?
0:47:56 - 0:49:34 – Are Statins Evil?
0:49:34 - 0:53:00 – Tests For Targeted Lipid Management
0:53:00 - 0:56:28 – Bempedoic Acid Vs. Statins
0:56:28 - 1:00:03 – Peter’s Multipronged Approach To Lipid Managing Pharmacology
1:00:03 - 1:05:22 – Sponsor: Marek Health (Preventive Medicine, HRT, & Rigorous Blood Work)
1:05:22 - 1:06:45 – Liver Toxicity And NAFLD
1:06:45 - 1:08:57 – Which Statins Are The Most Likely To Cause Side Effects?
1:08:57 - 1:10:49 – Repatha
1:10:49 - 1:14:04 – Will Obicetrapib Obliterate Atherosclerosis?
1:14:04 - 1:17:47 – Medications That Lower Lp(a)
1:17:47 - 1:25:01 – If Someone Has High Lp(a), But Excellent Metabolic Health, Can They Still Develop Premature Heart Disease?
1:25:01 - 1:26:50 – The Reason Why We Develop Plaque In Arteries, But Not Veins
1:26:50 - 1:27:33 – Maintain ≤ 120/80 Blood Pressure To Smash Your Risk Of Heart Disease And Dementia
1:27:33 - 1:28:34 – Is Lower Than 120/80 Better?
1:28:34 - 1:31:49 – How To Fix High Blood Pressure
1:31:49 - 1:34:12 – DEXA Scans And What A “Good” FFMI Is
1:34:12 - 1:36:24 – Is There Any Way To Verify Endothelial Damage?
1:36:24 - 1:38:16 – How Helpful Is A CT Angiogram?
1:38:16 - 1:40:06 – Can You Accurately Detect Plaque Accumulation In Yearly Intervals With CT Angiography?
1:40:06 - 1:43:47 – Why You Can Have No Detectable Inflammation In Bloodwork, But Still Develop Raging Atherosclerosis
1:43:47 - 1:51:24 – Why Peter Is Starting HRT, And What His Protocol Will Be
1:51:24 - 2:00:47 – Women’s Birth Control Options
2:00:47 - 2:05:42 – When Should Women Start HRT?
2:05:42 - 2:15:48 – Optimizing Women’s HRT Protocols
2:15:48 - 2:18:51 – The Prevalence Of Hypothyroidism
2:18:51 - 2:22:09 – When Should You Treat Inflammation With Supplements Or Medications?
2:22:09 - 2:24:48 – Will Cold Plunge Pre-Workout Inhibit Muscle Growth?
2:24:48 - 2:25:43 – Cold Plunge Increases Dopamine As Much As Coke!?
2:25:43 - 2:30:54 – Peter’s Use Of Modafinil, Nicotine, Caffeine, And What He Thinks The Best Nootropic Is
2:30:54 - 2:33:29 – How To Properly Dose Omega-3 Supplements
2:33:29 - 2:38:30 – Sponsor: Gorilla Mind (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations)
2:38:30 - 2:42:33 – What Actually Causes Brain Fog?
2:42:33 - 2:46:36 – How Obesity Impacts Mitochondrial Function
2:46:36 - 2:48:38 – Ideal Daily Magnesium Intake
2:48:38 - 2:51:42 – What Are The Most Important Sleep Metrics?
2:51:42 - 3:22:27 – F1 Talk
3:22:27 - 3:30:26 – Reconnecting Peter Attia With His Long-Lost Obsession... Tearing Phone Books!
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
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Hope you guys enjoy this clip from next week’s podcast with Peter Attia. We covered a lot of great topics, not just phone books. It goes live next Monday on the MPMD YouTube channel!
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
Instagram: https://www.instagram.com/moreplatesmoredates/
Twitter: https://x.com/Derek_Fitness
Snapchat: https://www.snapchat.com/add/derek-fit
TikTok: https://www.tiktok.com/@moreplates
Facebook: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
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Andrew’s Website & New Book: https://www.neverenough.com/
Andrew’s Social Media:
Twitter: https://x.com/awilkinson
YouTube: @NeverEnough2024
Instagram: https://www.instagram.com/awilkinson/
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📌 Sponsors/Limited Time Black Friday Deals:
⚕️ Marek Health - Preventive Medicine, HRT, Pharma Grade Hair Loss Treatments, & Rigorous Blood Work: https://bit.ly/373k791 | code "BLACK" for 25% off
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🕑 Timestamps:
0:00:00 - 0:03:09 – Who Is Andrew Wilkinson?
0:03:09 - 0:04:18 – Dropping Out Of College And Being A Barista For $6.50 CAD/Hour
0:04:18 - 0:06:22 – How Andrew Got Inspired To Learn How To Design Websites, Self-Educated, And Then Started Getting Jobs Doing It
0:06:22 - 0:08:02 – Warren Buffett, And How Andrew Emulated His Investing Strategy To Acquire And Build Businesses
0:08:02 - 0:12:59 – Working At McDonalds, The Gap, A Coffee Shop, And Getting The Cheat Codes To Entrepreneurship
0:12:59 - 0:18:26 – The 3 Most Impactful Books Andrew Has Ever Read
0:18:26 - 0:21:18 – Pound Valuable Information Into Your Head Multiple Times Instead Of Mass Consuming Content
0:21:18 - 0:25:49 – Why Would A Billionaire Spend Thousands Of Hours Writing A Book?
0:25:49 - 0:28:08 – Some Of Andrew’s Favorite Products And Services (Part 1)
0:28:08 - 0:33:24 – Sponsor: Marek Health (Preventive Medicine, HRT, Pharma Grade Hair Loss Treatments, & Rigorous Blood Work)
0:33:24 - 0:36:26 – Some Of Andrew’s Favorite Products And Services (Part 2)
0:36:26 - 0:46:43 – The Super Yacht Billionaire. The Grass Is ALWAYS Greener.
0:46:43 - 0:48:09 – Are Charities Almost Always Just A Ruse To Get Tax Breaks For The Ultra Wealthy?
0:48:09 - 0:52:00 – The Annual Income Amount Where Actual Happiness Level Peaks
0:52:00 - 0:53:48 – Almost All Billionaires Don’t Actually Have $1 Billion
0:53:48 - 0:57:34 – What Life Was Like When Andrew Was A Billionaire
0:57:34 - 1:01:20 – Andrew’s Screening Process To Invest In Winning Companies
1:01:20 - 1:02:10 – Corporate Tax Rates Going Up And Warren Buffett Selling A Ton Of Apple Stock
1:02:10 - 1:06:20 – Sponsor: Gorilla Mind (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations)
1:06:20 - 1:11:00 – Corporate Tax Rates Going Up And Warren Buffett Selling A Ton Of Apple Stock (continued)
1:11:00 - 1:16:13 – Living Where You Want Vs. Living Somewhere To Pay Less In Tax
1:16:13 - 1:20:16 – The Obscene Costs Of Real Estate In Vancouver And Toronto
1:20:16 - 1:23:10 – Do Most Successful Entrepreneurs From Canada Wish They Moved Out Of The Country Before Becoming Wealthy?
1:23:10 - 1:25:05 – The 3 Places Andrew Would Choose To Live If He Didn’t Live In Victoria
1:25:05 - 1:31:37 – If You Were Broke Again, How Would You Make Your First Million Dollars?
1:31:37 - 1:36:02 – Charlatans Who Got Rich Selling Courses On How They “Got Rich”
1:36:02 - 1:38:07 – The First Rule Of Fishing – Charlie Munger
1:38:07 - 1:41:42 – Luxury Clothes, And How Rich People Try To Covertly Flex Their Wealth
1:41:42 - 1:50:49 – Andrew’s Daily Routine Now Vs. When He Was Trying To Get Rich
1:50:49 - 1:53:25 – Acquiring A Yerba Mate Company With Andrew Huberman
1:53:25 - 1:55:46 – Asking Andrew If He’s Still Trapped On The Hedonic Treadmill
1:55:46 - 1:56:54 – Andrew’s Interest In Artistic Electronics
1:56:54 - 1:58:07 – Why Andrew Treats Himself Like An Addict To Avoid Social Media
1:58:07 - 2:02:27 – Andrew’s Experience With SSRI’s For Anxiety
2:02:27 - 2:07:47 – Some Of Andrew’s Favorite Products And Services (Part 3)
2:07:47 - 2:09:01 – Andrew’s Most Impactful Levers For Maximizing Productivity
2:09:01 - 2:09:57 – Where To Find Andrew’s New Book And His Podcast Hosting Me
————————————
Entrepreneur Andrew Wilkinson On His Experience Trying SSRI’s For His Lifelong Anxiety, And What Happened To His Mind Afterwards
————————————
Andrew’s Website & New Book: https://www.neverenough.com/
Andrew’s Social Media:
Twitter: https://x.com/awilkinson
YouTube: @NeverEnough2024
Instagram: https://www.instagram.com/awilkinson/
LinkedIn: https://www.linkedin.com/in/awilkinson/
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
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TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
Andrew’s Website & New Book: https://www.neverenough.com/
Andrew’s Social Media:
Twitter: https://x.com/awilkinson
YouTube: @NeverEnough2024
Instagram: https://www.instagram.com/awilkinson/
LinkedIn: https://www.linkedin.com/in/awilkinson/
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
————————————
📌 Check out the full video here: https://youtu.be/eNSx4sV-jys
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
————————————
INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#hormones #olympics #boxing
————————————
📌 Check out the full podcast here: https://youtu.be/JNpgqpyzW98
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Third-Party Tested Micronized Creatine Monohydrate: https://bit.ly/47XyJ8S | code "MPMD" for 10% off
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
————————————
INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
📌 Check out the full podcast here: https://youtu.be/IfRbc1E9boM
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Check out the full podcast here: https://youtu.be/JNpgqpyzW98
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
————————————
INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
————————————
Follow Me On
————————————
INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Third-Party Tested Micronized Creatine Monohydrate: https://gorillamind.com/products/creatine?variant=42386041929773&selling_plan=1077706797 | code "MPMD" for 10% off
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
————————————
INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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🦍 Gorilla Mode 2.0 Pre-Workout Is Now Live! | https://gorillamind.com/products/gorilla-mode | code "MPMD" for 10% off
————————————
📌 Table Of Contents:
• [0:00] Intro
• [1:58] What Changed and Why?
• [6:32] Summary Of Changes
• [13:54] The Formula
• [15:26] Dosage Changes
• [16:38] Ingredient Additions
• [17:57] Ingredient Removals
• [26:44] Flavors & Mixability
• [28:25] Formula Breakdown
○ [28:26] Essential Vitamins
∙ [30:08] Niacin (as Niacinamide) – 32 mg
∙ [30:34] P5P (Vitamin B6) (as Pyridoxal 5’-Phosphate) – 20 mg
∙ [31:56] Vitamin B12 (as Methylcobalamin) – 250 mcg
○ [33:05] Minerals & Electrolytes – 1430 mg
∙ [34:09] Impact Of Hydration
∙ [36:58] Pump, Performance, And Muscular Creatine Uptake
○ [41:26] Pure L-Citrulline (not Citrulline Malate) – 10,000 mg
∙ [45:49] Why Nitric Oxide Is Important
∙ [48:00] Muscular Endurance, RPE, And Relief Of Muscle Soreness
∙ [50:55] Explosive Power And Grip Strength
∙ [51:34] Vasodilation, Power Output, And Time To Exhaustion
∙ [52:13] Citrulline Vs. Arginine
∙ [53:12] Cardiometabolic Health
∙ [54:21] The Problem With Citrulline Malate In The Supplement Industry
○ [1:00:48] Malic Acid – 3000 mg
○ [1:05:30] Creatine Monohydrate – 5000 mg
∙ [1:05:57] How Much Can Creatine Increase Strength?
∙ [1:06:44] 10+ Pound Gain In A Week After Starting Creatine!? How Much Does Creatine Increase Muscle Size?
∙ [1:08:54] Carbohydrate Mediated Muscle Glycogen Supercompensation
∙ [1:09:39] Does Creatine Increase Your Natural Limit? The Effect On Satellite Cells & Myonuclei
∙ [1:10:58] Myostatin Levels
∙ [1:14:47] Cognitive Function
∙ [1:15:32] Do You Need To Supplement Creatine? Or Can You Get It Through Diet?
∙ [1:17:05] Methylation And Health Status
∙ [1:21:19] Why Include Creatine In A Pre-Workout If Its Effects Accumulate?
∙ [1:24:56] Does Timing Of When You Take Creatine Matter?
∙ [1:26:05] Do You Need To Cycle Off?
∙ [1:27:08] Does Creatine Cause Kidney Damage?
∙ [1:27:55] The Optimal Dosage
○ [1:30:20] L-Tyrosine – 5000 mg
∙ [1:31:03] The Pathway For Catecholamine And Trace Amine Synthesis
∙ [1:31:46] Reaction Time And Vigilance
∙ [1:31:59] Memory And Military Tracking Performance
∙ [1:32:54] Dextroamphetamine Vs. L-Tyrosine
∙ [1:34:52] Cognitive Flexibility
∙ [1:35:18] Endurance In Heat
○ [1:36:56] Betaine Anhydrous (Trimethylglycine) – 4000 mg
∙ [1:38:53] Muscular Strength, Power, And Size
∙ [1:43:23] Homocysteine And The Vasodilation Brick Wall
∙ [1:47:33] The Optimal Dosage (More Isn’t Always Better)
○ [1:51:20] Hydroprime® Glycerol Powder (65%) – 4000 mg
∙ [1:52:35] IV Infusion Of Fluids Vs. Oral Glycerol For Enhancing Endurance
∙ [1:53:52] Aerobic And Anaerobic Performance
∙ [1:54:30] The Synergistic Effect Of Glycerol + Creatine
∙ [1:58:35] Dosage
∙ [2:01:14] Why We Switched From Glycerpump® To Hydroprime®
○ [2:02:54] Alpha-GPC 50% (L-alpha-glycerylphosphorylcholine) – 800 mg
∙ [2:03:59] Memory, Focus And Overall Cognitive Function
∙ [2:06:25] HGH Production
∙ [2:07:19] Force Production And Power Output
∙ [2:11:41] Motivation Levels
∙ [2:12:43] Alpha-GPC Vs. Citicoline (CDP-Choline)
∙ [2:17:37] How Much Choline Do You Need Per Day?
∙ [2:19:05] How Choline Affects Methylation And Health Status
○ [2:21:15] Caffeine Anhydrous – 400 mg
∙ [2:22:23] Strength And Power
∙ [2:27:09] Workload When Well-Slept Vs. Sleep Deprived
∙ [2:27:58] Energy Expenditure (Calories Burned) Per Day
∙ [2:28:47] Alertness, Wakefulness And Readiness
∙ [2:29:09] Attention And Concentration
∙ [2:29:45] Working Memory
∙ [2:30:22] Reaction Time
∙ [2:31:44] Mental Fatigue
∙ [2:31:55] The Minimum Effective Dose
∙ [2:33:10] The Dosage Necessary For Enhanced Mental Or Physical Performance
∙ [2:36:22] Should You Wait 90 Minutes After Waking Up To Take Caffeine?
○ [2:44:17] Huperzine A – 200 mcg
∙ [2:44:31] Cholinergic Activity
∙ [2:46:35] Dopaminergic Activity
∙ [2:47:36] Participants Infused With IV Cocaine
• [2:49:57] Ingredients I Didn’t Include In The Formula And Why
• [3:55:12] Conclusion
————————————
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⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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TWITTER: https://twitter.com/Derek_Fitness
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TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Check out the full podcast here: https://youtu.be/IfRbc1E9boM
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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TWITTER: https://twitter.com/Derek_Fitness
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TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd
📌 Check out the full podcast here: https://youtu.be/bLyFvocD-eU?si=mqvX0-GOnUsAsVKR
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#craigjones #gordonryan #nickyrod
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📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#craigjones #cji #jiujitsu
————————————
🐟 Omega-3 Elixir™ Is Now Live! The Most Robust & Rigorously Vetted Omega-3 Support: https://gorillamind.com/products/omega-3-elixir | code "MPMD" for 10% off (and another 20% off on subscriptions)
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Follow Me On
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#fishoil #omega3 #supplements
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⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd
————————————
🕑 Time Stamps:
0:00:00 - Craigs Jones’ first time in Canada and the guy who threatened to kill him
0:02:00 - Who is Craig Jones?
0:02:57 - The $3 million CJI tournament anonymous donor, and bringing $1 million cash on Joe Rogan’s podcast
0:05:43 - Why Craig started Jiu-Jitsu. MMA was illegal in Australia
0:06:47 - Why Joe Rogan refuses to come to Canada. Would Derek ever leave Canada?
0:12:45 - Jiu-Jitsu vs MMA and the ROI for the risk of brain damage
0:13:23 - Beating drug testing in tested sports
0:14:29 - Who are the most elite Jiu-Jitsu athletes who could also do well in MMA?
0:16:56 - There was no money in Jiu-Jitsu when Craig started
0:18:01 - The misconception that Jiu-Jitsu isn’t gay and weird
0:19:38 - The top 3 martial arts you should learn to defend yourself
0:21:12 - The most important form of combat to learn first before anything else
0:21:59 - The most ineffective combat skill that is often mistakenly believed to be useful
0:24:29 - Bragging rights of winning tournaments
0:25:59 - How B-Team is playing 4D chess by claiming to be the second best
0:27:40 - Craig’s Instagram beefs, and who the weirdest athletes are
0:28:50 - Brazilian Jiu-Jitsu (BJJ) vs. Jiu-Jitsu
0:30:21 - The kids who came up to Derek on the beach asking about building muscle for Jiu-Jitsu
0:31:33 - How train to progress as quickly as possible in Jiu-Jitsu
0:32:41 - The curse of Larry Wheels, and athletes ruining their careers by training stupidly
0:35:52 - The performance downsides of getting juiced out of your mind massive for Jiu-Jitsu
0:37:24 - The Danaher Death Squad and why Craig, Nicky Ryan, Nicky Rod, and Ethan Crelinsten left
0:39:34 - How hard is it to get a black belt and how long does it take? Is it a covert multi-level marketing scheme?
0:47:28 - How to optimize week of training to max out progress in Jiu-Jitsu
0:49:28 - How to learn submissions as quickly as possible
0:51:39 - Craig's tier list for the best and worst submissions
0:55:45 - The craziest submission Craig has ever hit
0:56:44 - Jiu-Jitsu paywalled instructional videos from elite athletes
1:00:00 - Why most of the best Jiu-Jitsu athletes in the world make less than $100K per year
1:02:27 - The top prizes for winning the most elite submission grappling competition in the world (ADCC), and now the $2.6 million at stake for the first Craig Jones Invitational (CJI)
1:03:30 - The identity of the anonymous donor who put up $3 million for CJI
1:05:15 - Why Craig is so motivated to take down ADCC
1:07:18 - Sponsor: Marek Health
1:08:37 - The super fights, custom fight pit to push action, and why CJI will be the most elite, high stakes, grappling tournament on earth
1:18:28 - The origins of the Abu Dhabi Combat Club (ADCC)
1:19:27 - Craig’s blood work and his review of Marek Health so far
1:21:27 - The importance of expert oversight in Jiu-Jitsu to optimize health, performance, and longevity in the sport
1:25:48 - Do you need to be on PEDs to excel in Jiu-Jitsu?
1:29:15 - The world championship combination of autism and steroids in Jiu-Jitsu
1:30:51 - Life changing money at CJI. Winning $1 million at CJI vs. ADCC prestige
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#hormones #olympics #boxing
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0:00:00 - 0:03:38 – What Is “The Vertical Diet”?
0:03:38 - 0:09:53 – 98 Pounds In High School - How Stan Delayed Puberty By Not Eating Or Sleeping Enough
0:09:53 - 0:12:43 – 145 ng/dL Testosterone Level At 20 Years Old – Discovering His Varicocele, Hypogonadism Diagnosis, And Getting On Testosterone
0:12:43 - 0:14:58 – The Steroid Cycle Stan Used In The 90’s To Get To Nearly 300 Pounds
0:14:58 - 0:18:33 – How To Determine If You Have IFBB Pro Bodybuilder Caliber Genetics
0:18:33 - 0:20:27 – Stan’s Thoughts On Cycling Off Vs. Blasting And Cruising
0:20:27 - 0:21:28 – The Results Of Stan’s Varicocele Surgery
0:21:28 - 0:25:00 – Female Softball Players Who Became Anemic From Removing Red Meat, Dairy, Fruit, And Egg Yolks
0:25:00 - 0:30:03 – Sponsor: Marek Health
0:30:03 - 0:34:22 – Bulking And Cutting Mistakes Preventing Progress
0:34:22 - 0:36:13 – When Are You Too Fat To Bulk?
0:36:13 - 0:44:09 – Permabulking And Staying Healthy While Pushing The Scale
0:44:09 - 0:44:45 – Mitchell Hooper’s Diet For The World’s Strongest Man
0:44:45 - 0:45:40 – Dairy
0:45:40 - 0:46:33 – Fermented Foods - Yogurt, Kefir, Kimchee, Gut Microbiome
0:46:33 - 0:49:48 – Keto Diet Advocates Who Transitioned Back To Including Carbs
0:49:48 - 0:54:04 – The Majority Of Health Benefits From Any Diet Coming From Weight Loss
0:54:04 - 0:55:32 – Paul Saladino’s Bold Assertion About APOB And Metabolic Health
0:55:32 - 0:59:05 – Anthony Chaffee, People With High LDL-C Live Longer?
0:59:05 - 1:03:26 – How Dana White ACTUALLY Transformed (weight loss and TRT) – Gary Brecka’s Wild Claims
1:03:26 - 1:04:53 – Addressing Vitamin Deficiencies
1:04:53 - 1:09:38 – The Ideal Protein Intake For Steroid Users Vs. Nattys
1:09:38 - 1:14:15 – The Best Diet For Weight Loss
1:14:15 - 1:16:38 – One Of The Main Ways Diet Can Lead To Ruthless Brain Fog
1:16:38 - 1:20:02 – The Utility Of Continuous Glucose Monitors (CGM’s)
1:20:02 - 1:20:44 – Why It’s Worthwhile To Count Calories (at least for a bit)
1:20:44 - 1:26:31 – Are Seed Oils Actually Unhealthy?
1:26:31 - 1:28:11 – How Hafþór Júlíus Björnsson Got Up To A Healthier 440 Pounds
1:28:11 - 1:33:39 – After Losing Weight Should You Stop Using Your CPAP Machine For Sleep Apnea?
1:33:39 - 1:38:31 – “It Was Absolutely Horrible!” - Stan Describes Coming Off Testosterone After 10 Years
1:38:31 - 1:41:33 – Why Stan Decided To Go Back On Steroids In 2006 At 39 Years Old
1:41:33 - 1:45:24 – The Steroid Cycle, Training, & Diet Flex Wheeler Put Stan Efferding On To Win His IFBB Pro Card In Bodybuilding
1:45:24 - 1:48:14 – Powerlifter Vs. Bodybuilder Steroid Use - Stan’s 2009 Stack To Hit A 2,221.2 Pound Total
1:48:14 - 1:56:17 – Getting Stronger But Not Getting Bigger - The “Horrible Lesson” IFBB Pro Stan Efferding Learned About Muscle Growth
1:56:17 - 2:01:38 – The Biggest Steroid Cycle Stan Efferding Has Ever Ran And What Happened - At A Point, Less Is More
2:01:38 - 2:03:43 – Can You Grow Muscle On Steroids Without Even Training?
2:03:43 - 2:05:36 – The Steroid Dosages IFBB Pro Bodybuilders Typically Take
2:05:36 - 2:11:30 – How Stan Approaches His Steroid Use And Training Now At 56 Years Old
2:11:30 - 2:15:48 – Stan’s Experience Using Growth Hormone And Insulin
2:15:48 - 2:18:25 – Stan’s Updated Recommendations On Sodium Intake
2:18:25 - 2:19:51 – Stan’s Updated Opinion On Seed Oils And Getting Sufficient Omega 3’s
2:19:51 - 2:28:10 – An Example Full Day Of Vertical Diet Eating For The Average Guy Trying To Gain Muscle
2:28:10 - 2:38:34 – The Most Impactful Changes Stan Made Working With Jon Jones, Hafþór Björnsson, Brian Shaw, Lane Johnson, Henry Cejudo, Mitchell Hooper, Gordon Ryan, And Other Elite Athletes He’s Worked With
2:38:34 - 2:44:08 – Organic Food Is A Scam? How Much Of A Difference Is There In Quality Between Organic Vs. Conventional Meat, Eggs, Fruit, And Vegetables? Grass-Fed Vs. Grain-Fed Beef. Fresh Vs. Frozen Fruit.
2:44:08 - 2:45:15 – Where To Buy The Vertical Diet 4.0 And Where To Follow Stan For More Information
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🕑 Time Stamps:
0:00:00 – 0:00:50 – Introduction
0:00:50 – 0:05:32 – Why Paul Saladino Stopped The Carnivore Diet After 2 Years
0:05:32 – 0:08:41 – Is There Ever A Point Of Doing A Keto Diet?
0:08:41 – 0:11:21 – Why Paul Reached Out To Me To Do A Second Podcast After Seeing Me Speak With Peter Attia
0:11:21 – 0:17:36 – What Actually Causes Atherosclerosis? Paul’s Take On The Traditional Hypothesis
0:17:36 – 0:22:17 – Should We Ignore High LDL-C Or APOB?
0:22:17 – 0:25:05 – Paul Describes How Some Studies Suggest That Those With Higher HDL-C Levels May Be Less Likely To Get Atherosclerosis Despite Having High LDL-C Levels
0:25:05 – 0:25:26 – Paul’s Perspective On Why Many Doctors Aren’t Educating Their Patients About Metabolic Health
0:25:26 – 0:33:41 – "Ignore Nutrition Just Focus On Exercise"
0:33:41 – 0:37:55 – Sponsor: Eight Sleep
0:37:55 – 0:39:02 – The Most Important Lab Tests For Avoiding Atherosclerosis
0:39:02 – 0:42:53 – Is It Possible To Get Atherosclerosis If You Have A Fasting Insulin Of 3 uIU/mL Or Less
0:42:53 – 0:46:27 – Familial Hypercholesterolemia (FH) And Why It’s A Phenotypic Diagnosis, Not A Genotypic Diagnosis
0:46:27 – 0:49:41 – What Happens When You Replace Saturated Fat With Linoleic Acid?
0:49:41 – 0:52:38 – How A Pure Carnivore Diet Affects Thyroid Metabolism
0:52:38 – 0:56:45 – Can Someone On A Keto Diet Long-Term Develop Atherosclerosis Despite Having A Low Fasting Insulin? Dave Feldman’s Lean Mass Hyper-Responder Study
0:56:45 – 1:00:56 – How Paul’s Perspective Differs From Dave Feldman and Shawn Baker
• The Baseline Data From The LMHR Study Paul Mentioned: https://twitter.com/realDaveFeldman/status/1733387107610063195
1:00:56 – 1:03:55 – What Is APOB And LP(a)?
1:03:55 – 1:06:44 – Sponsor: Marek Health
1:06:44 – 1:10:21 – How Long It Takes For Plaque To Develop And Show On A CT Angiogram
1:10:21 – 1:13:46 – Why Paul Uses Proxy Biomarkers In Atherosclerosis Data Analysis To Discern Insulin Sensitivity
1:13:46 – 1:18:14 – Does Paul Think It Is Ever Justified To Take Lipid Lowering Medication To Avoid Atherosclerosis?
1:18:14 – 1:20:13 – How Should You Track If You Are Developing Atherosclerosis?
1:20:13 – 1:45:27 – Lipid Lowering Medication Risk-Reward Analysis. Will Lowering LDL-C Impair Quality Of Life, Regardless Of The Medication Used? Do Adolescents With Hypofunctioning PCSK9 And Very Low APOB Have Impaired Development Cognitively Or Structurally?
1:45:27 – 1:47:39 – If You Don’t Lower APOB But Want To Track Plaque Accumulation, Is The Dose Of Radiation From A CT Angiogram Concerning?
1:47:39 – 1:56:45 –Why Certain Tribes Have Lower Rates Of Cardiovascular Disease Than The Average Person. Should Or Shouldn’t We Copy What They’re Doing?
1:56:45 – 2:16:17 – The Lowest Hanging Fruit For Avoiding Atherosclerosis And Evaluating Your Risk
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Time Stamps:
00:00:00 - Peter Attia’s new book ‘Outlive’
00:02:26 - Who is Peter Attia? What is Medicine 3.0?
00:03:28 - Peter Attia’s career. How did he become a doctor? And how did he evolve into his unique approach to preventative medicine?
00:07:54 - What do the acronyms in Peter’s Instagram bio stand for?
00:13:53 - The Four Horseman of Death (most will die from one of these)
00:22:46 - How to not die from atherosclerotic disease (the leading cause of death)
00:29:59 - The impact of smoking on atherosclerotic disease
00:30:36 - The impact of high blood pressure (hypertension) on atherosclerotic disease, how common it really is, and how to track it
00:32:32 - The accuracy of manual vs. automatic blood pressure cuffs
00:35:41 - The impact of APOB/all atherogenic particles (LDL’s, LP(a)’s, VLDL’s, and IDL’s) on atherosclerotic disease
00:40:57 - The minimum APOB level needed for adequate function
00:42:43 - PCSK-9 gene and its effect on LDL. How PCSK-9 inhibitors work to lower LDL
00:43:24 - APOB vs. APOA
00:44:56 - The most effective lipid managing dr*gs for preventing atherosclerosis
00:50:16 - Why Peter doesn’t see a reason why anybody should have an APOB over 60 mg/dL
00:52:15 - If Peter could go back in time knowing what he knows now and with modern pharmacology, at what age would he start lowering his APOB
00:55:04 - Arterial plaque accumulation starts as early as when you are a teenager. Calcification takes years to show up on a coronary CT calcium scan, but that does not mean plaque isn’t accumulating
00:57:12 - Should you screen for atherosclerosis before taking medication? If so, how?
01:01:06 - Why are carnivore diet zealots so dogmatic about cholesterol and atherosclerosis? What does the data show to date?
01:06:05 - If those with average genetics maintain a near perfect diet, exercise regimen and sleep hygiene, will many of those individuals still develop atherosclerosis?
01:09:41 - How to lower blood pressure
01:13:25 - Sleep Apnea and the use of CPAP
01:16:49 - Cancer: Causes, Prevention, and Proactive Screening
01:35:53 - The devices and metrics Peter uses to track his sleep and recovery
01:41:50 - Resting heart rate, HRV, heart rate recovery, and how predictive they are of mortality
01:44:43 - Peter's full daily routine and diet
01:54:35 - Why Peter stopped fasting
01:57:12 - Bodybuilders abuse of T3, Clen, DNP, and other metabolic modulators
01:58:54 - Peter breaks down his 6000+ calorie diet, 6 hours of daily exercise, and the most absurd meals he ate to maintain his weight when he was younger
02:01:25 - How Peter’s kids eat. How strict should the diet be for your kids when it comes to food quality to maximize growth potential?
02:07:41 - Where is the best burger in Austin?
02:08:22 - What time Peter stops eating each night, and the hack he uses to prevent him from overeating
02:11:33 - Peter's non-negotiable nightly practices for maximizing sleep quality
02:12:31 - Why Peter has a Bat phone
02:14:29 - How to live in the moment and be happy. The vicious circle of financial success and/or accolades never being enough.
02:22:46 - How to decide if you should have kids
02:25:13 - Peter’s Top 10 Supplements and Top 10 Dr*gs
02:29:35 - Peter's personal supplement stack and dr*g protocol
02:42:26 - Homocysteine reduction protocol
02:44:11 - Vitamin B6 deficiency paradoxically caused by Pyridoxine Hydrochloride supplementation
02:46:00 - How safe is TRT for cardiovascular health? TRAVERSE clinical trial results
02:51:31 - Comparison of TRT administration methods. What Peter prefers for patients
02:52:40 - What podcasts and YouTube channels Peter likes to watch or listen to
02:55:09 - Formula 1
02:55:54 - AlphaTauri x Hugo Boss
02:56:21 - Daniel Ricciardo, Max Verstappen
02:59:33 - How Red Bull became such a dominant F1 team
03:01:35 - Sim racing
03:05:13 - How Peter got so interested in F1
03:06:33 - Peter’s dream car
03:06:50 - Ayrton Senna
03:08:25 - Outro
📌 Intelligent Microneedling Pen: https://intelligent.shop/products/intelligent-microneedling-pen 📌 Intelligent Derma Roller: https://intelligent.shop/derma-roller
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📩 My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: http://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
THREADS: https://www.threads.net/@moreplatesmoredates
FACEBOOK: https://www.facebook.com/moreplates/
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TWITTER: https://twitter.com/Derek_Fitness
TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#HairLoss #Minoxidil #IntelligentShop
————————————
Alex's Instagram: https://www.instagram.com/hormozi/
Alex's YouTube Channel: https://www.youtube.com/c/AlexHormozi
————————————
💊 Head over to https://thld.co/seed_derek_0622 to get 15% off your first month’s supply of Seed’s DS-01™ Daily Synbiotic using code DEREK at checkout.
🪒 Get 20% OFF @MANSCAPED + Free Shipping with promo code DEREK at https://www.MANSCAPED.com/
————————————
Time Stamps:
00:00:00 – Alex’s unique entrepreneurial content with no “secrets” withheld
00:03:03 – Alex’s journey from broke to $100 million revenue per year
00:08:49 – Software and machine learning to maximize leads, and does Alex regret starting a software company
00:12:10 – The inception of Acquisition.com, qualifications (revenue, net profit, types of companies, founder character traits etc.) needed for Alex to consider buying/taking on a minority stake in a new company he will add to his portfolio, and how he grows them quickly
00:40:02 – Alex’s perspective on the stock market, crypto, real estate, and why he’s mostly liquid and sitting on cash
00:43:01 – How much equity do you need to have enough skin in the game for a minority stake to be worth your time to grow the company?
00:43:43 – How Alex oversees the 8 companies he has equity in simultaneously
00:47:52 – Valuation calculations of companies, negotiating it during corporate exits, and how much Alex sold his last 3 companies for
00:55:45 – Tax strategy during corporate exits
00:59:38 – The most challenging aspects of scaling multiple 8 figure companies
01:01:51 – Finding executives and A player employees when scaling, and how to compensate them
01:08:52 – The real secret to get from $10 million to $100 million. The billion-dollar skill.
01:11:10 – Have you fired any executives, and if so, what were the reasons?
01:13:03 – Why Alex had to hire and fire 8 executive assistants until he found a winner. The difference between an administrative and executive assistant. Yearly salaries for assistants.
01:20:30 – High net worth goals have long-term time horizons, but does Alex also micro-segment his goals into yearly or quarterly objectives?
01:26:46 – Tax secrets of the wealthy and what happens when we die
01:36:16 – Entrepreneurs living somewhere they don’t want to live to save on taxes
01:39:02 – The corporate structure of Acquisition.com (LLC vs. C-Corp vs. ESOP)
01:43:10 – How much Alex spends per month to maintain his lifestyle (living like a**holes)
01:45:20 – Social awkwardness around people you don’t share common interests with
01:47:49 – Alex and I each give our reasons why we don’t want kids right now
01:50:49 – What is the most overrated piece of business advice among high-net-worth entrepreneurs? The lady in the red dress
01:54:42 – Delayed gratification and sacrificing long-term enterprise value for today’s cash value
01:57:49 – Should you take distributions or reinvest everything back into your business?
01:59:49 – Fake millionaires and our thoughts on college/university
02:06:32 – What a day in the life of Alex Hormozi looks like - How his schedule and task lists break down start to finish to optimize his time
02:15:20 – Alex and I discuss our productivity hacks to stay focused and avoid distractions
02:19:45 – Alex’s strict sleep schedule and how it adjusted the past few years
02:22:02 – Biohacks used by high performing entrepreneurs
02:25:15 – Brain fog from hard training and being “passively jacked”
02:28:16 – The biggest Alex has ever gotten, his lifts and bodybuilding stats over the years, TRT and if he is natty or not
02:37:19 – Alex’s diet. What each meal looks like every day. Productivity while fasting vs. eating.
02:40:15 – Alex’s experience with “smart drugs” and what he currently takes
02:47:30 – Entrepreneurs that ruin their productivity by trying to over-optimize their day for productivity
————————————
Greg's Instagram: https://www.instagram.com/gregogallagher/
Greg's YouTube Channel: https://www.youtube.com/c/Kinobody
————————————
🥬 To get a 1 year supply of Vitamin D3 & K2 + 5 individual travel packs for free with your first purchase, go to https://athleticgreens.com/moreplatesmoredates
💊 Use code DEREK at checkout for 15% off your first month's supply of Seed's Daily Synbiotic: https://thld.co/seed_derek_0422
————————————
🕑 Time Stamps:
0:00 - Steroid Accusations And How He Healed His Ruthless Elbow Tendinitis
9:16 - Lifting Only 3 Days A Week For Maximum Gains - How To Gain Muscle & Strength
37:53 - How Long It Takes To Reach Your Genetic Limit And How To Beat PR's Once You've Plateaued
55:23 - How Much Faster Would You Get To Your Genetic Peak If You Didn't Cut
1:02:09 - How Greg O'Gallagher Stays Below 10% Body Fat Year Round Naturally Without Doing Cardio Or 10,000 Steps
1:30:00 - Number 1 Piece Of Advice For Young Men
1:44:56 - Testosterone Makes Effort Feel Good, Sleep Regimen & Edibles Crushing Motivation
1:54:49 - Scientifically Dismantling Greg O'Gallagher's Blood Test Results
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks)
💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off
⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off
🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
TWITTER: https://twitter.com/Derek_Fitness
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TIKTOK: https://www.tiktok.com/@moreplates
FACEBOOK: https://www.facebook.com/moreplates/
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Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#moreplatesmoredates #gregogallagher #kinobody
————————————
Paul's Instagram: https://www.instagram.com/carnivoremd2.0/
Paul's YouTube Channel: https://www.youtube.com/c/PaulSaladinoMD
————————————
🥄 Go to https://magicspoon.com/derek and use code DEREK to get your own variety pack of macro friendly/high protein cereal for $5 off
💊 Use code DEREK at checkout for 15% off your first month's supply of Seed's Daily Synbiotic: https://thld.co/seed_derek_0422
————————————
Time Stamps:
0:00 - Intro
6:35 - Eating Raw Meat, Effective Dose Of Liver & The Most Important Organ Meats
26:41 - Jordan Peterson And Why Paul Saladino Switched From A Vegan Diet To A Carnivore Diet
46:59 - Paul Saladino On Horrible Free Testosterone Levels On Keto And Carnivore Diets
54:04 - Paul Saladino - The TRUTH About "Mental Clarity" On Ketogenic Diets And Eating Sugar With Red Meat
1:04:52 - Paul Saladino's Macros That Keep Him Shredded And Daily Routine For Productivity
1:18:20 - Paul Saladino's Routine To Get Optimal Sleep Quality (lights, EMF, diet, circadian rhythm, etc.)
1:29:03 - Paul Saladino On Liver King & If Medications/Supplements Can Substitute As Hormetic Stressors
1:46:11 - Paul Saladino On The New Controversial Metformin Study And Diabetes
2:01:58 - How To Cure Jada Pinkett Smith's Alopecia Areata & Leaky Gut Explained - Paul Saladino Weighs In
2:15:08 - Paul Saladino Getting Railroaded By "The Doctors" On TV
2:25:02 - Is The Carnivore Diet Affordable? How Much Muscle Meat And Organs Paul Saladino Eats Per Day
2:27:07 - Paul Saladino On His Sky High Cholesterol Levels And What Actually Causes Atherosclerosis
2:35:19 - Are Enhanced Bodybuilders All Screwed Because Of Their Low HDL Levels?
2:42:02 - Is Fructose Unhealthy? Should You Avoid Fruit? Should You Shop Organic?
2:47:08 - Paul Saladino On Hitting Micronutrient Needs, The Healthiest Water Filter & Biohacking
2:53:57 - Lean Mass Hyper-Responders & Carbs For Bodybuilding
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
THREADS: https://www.threads.net/@moreplatesmoredates
FACEBOOK: https://www.facebook.com/moreplates/
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TWITTER: https://twitter.com/Derek_Fitness
TIKTOK: https://www.tiktok.com/@moreplates
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#MorePlatesMoreDates #PaulSaladino #CarnivoreDiet
————————————
📌 You can purchase Dan's new book "The Setup" here: https://dbthesetup.co/
————————————
Dan's Social Media:
Instagram: https://www.instagram.com/danbilzerian
Facebook: https://www.facebook.com/danbilzerianofficial
Twitter: https://twitter.com/DanBilzerian
TikTok: https://www.tiktok.com/@danbilzerian
YouTube: https://www.youtube.com/c/danbilzerian
————————————
📍 Sponsors:
💊 Use code DEREK at checkout for 15% off your first month's supply of Seed's Daily Synbiotic: https://thld.co/seed_derek
🥄 Go to https://magicspoon.com/derek and use code DEREK to get your own variety pack of macro friendly/high protein cereal for $5 off
————————————
🕑 Time Stamps:
00:00:00 – What Caused Dan's Heart Attack
00:04:20 – The Mind Warping Effect of Fame and Wealth at a Young Age
00:12:00 – Taxes on High Stakes Poker Earnings and Losses
00:15:06 – NFTs, CryptoPunks & If He Regrets Cashing Out of Bitcoin at $16,500
00:34:37 – Floyd Mayweather's Instagram Promo's, Steve Aoki & Social Media Strategy
00:41:32 – The Media's Portrayal of Dan's Downfall
00:48:43 – "Magic Juice", PED Use (Tren?) and Stem Cells
01:10:49 – The Natty Legend Mike O'Hearn
01:16:53 – Trans Athletes, Doping and The Capabilities of a Natty Physique
01:23:34 – How Dan Bilzerian Trained Himself to do Well with Women in College and Frat Life
01:37:18 – "The Game", Mystery Method and the OG Pick Up Artists
01:46:29 – Banging the Former CEO of Bodybuilding.com's 22 Year Old Girlfriend
01:55:02 – How Age Impacts Your Appeal to Women, Racial Disparity
02:10:32 – Tinder, Bumble and If Going to College is still Worth It
02:20:08 – Social Media and Smartphones are Modern Day Distractions
02:27:51 – NEW Perspective on Smoking and Dating Older Women
02:35:01 – Small Nuts And How My Deca Video Gave Him ED
02:40:50 – Melanotan II Transformations, Peptides, Ice Baths & His Current Diet
02:50:31 – Dan Bilzerian's Unfiltered Opinion on Dwayne 'The Rock' Johnson
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
————————————
Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
THREADS: https://www.threads.net/@moreplatesmoredates
FACEBOOK: https://www.facebook.com/moreplates/
SNAPCHAT: https://www.snapchat.com/add/derek-fit
TWITTER: https://twitter.com/Derek_Fitness
TIKTOK: https://www.tiktok.com/@moreplates
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#MorePlatesMoreDates #DanBilzerian #Podcast
————————————
Go to https://thld.co/seed_dereknov and get 15% off your first month’s supply of Seed’s Daily Synbiotic by using code DEREK at checkout. Thanks to Seed for sponsoring today’s video.
————————————
🕑 Time Stamps:
00:00 - NAFLD
05:47 - Joesthetics & rippling muscles disease
12:58 - Trap Lore Ross YouTube channel
15:56 - Merchandise
18:45 - Top Mr. Olympia bodybuilder cycle review intro
21:45 - Bloodwork review
37:35 - Recommendations for next blood test part 1
41:06 - Wearable technology
45:03 - Recommendations for next blood test part 2/prostate
46:24 - Scanning/How to get it Thailand & Dubai
48:31 - Liver notes/health/protocol
49:36 - Udca/tudca + rest of liver protocol
57:18 - Sponsor
1:06:03 - Ancillary medications
1:06:47 - Post cycle therapy/fertility and bodybuilders coming FULLY off cycle
1:18:08 - Bloodwork findings/LDL
1:23:57 - ApoeB
1:27:57 - Bloodwork findings/blood pressure
1:28:56 - Bloodwork findings/cardiovascular health
1:31:33 - Bloodwork findings/liver
1:32:13 - Bloodwork findings/kidney/creatine/cyastatin C
1:34:52 - Bostin Loyd's health
1:36:47 - Creatine for bodybuilding
1:39:57 - Changes on bloodwork/internal bleeding
1:42:54 - Mr. Olympia contest prep cycle review
2:00:58 - Our opinion on the cycle/heart problem
2:10:08 - Leo’s story of the guy in Dubai with synthol + Wesley Vissers + round shoulders
2:15:06 - Tony Huge, Nick Trigili
2:17:55 - Weeks 10 to 6
2:23:26 - Protocol design 14 weeks in advance
2:27:57 - Weeks 6 to 4
2:31:21 - Injectable winstrol, leaving cosmetic compounds to the end
2:34:43 - SERMs + AIs, overlapping AIs
2:42:26 - Empiricism vs. theory in cycle design
2:45:20 - Confirmation bias/sampling
2:50:24 - Multiple DHT-based compounds?
2:53:26 - End of Olympia cycle review
2:54:34 - Why we presented this information to the audience
3:01:09 - Having a positive calcium score at 40/Guy Cisternino and Lee Priest CAC scores
3:02:31 - The need for prophylactic lipid management for bodybuilders: ezetimibe, statins, PCSK9i
3:04:02 - Is Steve going bald?
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
————————————
Follow Me On
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INSTAGRAM: https://www.instagram.com/moreplatesmoredates/
THREADS: https://www.threads.net/@moreplatesmoredates
FACEBOOK: https://www.facebook.com/moreplates/
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TWITTER: https://twitter.com/Derek_Fitness
TIKTOK: https://www.tiktok.com/@moreplates
————————————
Subscribe To The More Plates More Dates Podcast
————————————
Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
————————————
#MorePlatesMoreDates #MrOlympia #Bodybuilding
————————————
📌 Noel's Social Media:
YouTube: https://www.youtube.com/c/NoelDeyzel
Instagram: https://www.instagram.com/noeldeyzel_bodybuilder/
TikTok: https://www.tiktok.com/@noeldeyzel_bodybuilder/
————————————
🥄 Go to https://magicspoon.thld.co/DEREK_1021b and use code DEREK to get your own variety pack for $5 off (cinnamon, frosted, peanut butter and cocoa are still my favorites right now)
————————————
🕑 Time Stamps:
0:00 - How to pronounce “Noel Deyzel”
1:00 - How quickly Noel’s social media has exploded
1:55 - Starting training at 23-24 years old and the sports Noel used to play
3:49 - Getting injured shortly after blowing up on TikTok
5:05 - Noel's starting stats before he started training and how much size he’s gained since then
7:04 - Upcoming plans for getting on stage and competing and Olympia aspirations
9:57 - Maintaining a leaner physique year round
11:10 - Noel's thoughts on the 2021 Mr. Olympia results and aesthetics vs. sheer mass
18:47 - Bodybuilding goals vs. a rigorous social media and business schedule
23:54 - Noel's software company
25:39 - Noel’s social media team and what he allocates his time to each day
27:22 - How long it takes Noel to make his videos and the process that goes into each
29:53 - Getting comfortable on camera
32:21 - Transitioning between entertainment and educational content
33:40 - Was there a specific video that went viral, or a moment that motivated Noel to go all in on social media?
38:16 - The “honeymoon phase” on TikTok and new creators blowing up
42:29 - Does Noel watch TikTok content himself?
44:32 - The longevity of TikTok and if new creators should focus on it as their main platform
48:08 - Making money off social media
50:46 - Noel's unique video style (lighting, quality, entertainment, information, etc.)
53:44 – People assuming we live in a different country
56:02 - How people started calling Noel “Daddy Noel”
1:00:13 - Noel's GTR
1:01:13 - Noel's dream car
1:01:44 - Honda Civic Type R (FK2)
1:02:20 - Aspiring to get the GTR and buying one
1:07:00 - Wide Body Liberty Walk Silhouette GTR
1:09:25 - Noel's plan to immigrate to the US and my own plans
1:12:41 - New content being worked on behind the scenes
1:15:04 - Noel's most and least favorite types of videos to make
1:18:36 - Sponsor
1:24:59 - Noel gives us a behind the scenes tour of his gym he films and trains in
1:30:45 - Will Noel start an OnlyFans?
1:33:02 - The strangest requests Noel has received (spoiler: they’re weird)
1:35:42 - WanderBoy2010, Producing House Music, Cringing At Old Content & Sus Comments
1:42:09 - The way people treat Noel now that he’s an internet celebrity
1:48:23 - Noel’s upbringing, building his company and discipline
1:51:29 - How Squid Game derailed us
1:53:20 - Avoiding burnout and what a structured week looks like now
1:55:41 - How diagnosing his sleep apnea changed Noel’s life and getting used to a mask strapped to your face with a CPAP machine
2:05:27 - Our struggles with maintaining a dialed in circadian rhythm
2:09:40 - The story of Noel’s first cycle and why he is open about his use of anabolics
2:16:09 - How Noel started his education about anabolics/bodybuilding pharmacology
2:19:30 - What Noel would’ve changed in his approach to bodybuilding if he could go back in time
2:20:37 - The double-edged sword of social media when it comes to education about bodybuilding pharmacology
2:26:44 - Noel’s experience with judgmental doctors, the importance of preventative medicine, lab work, diagnostics and getting high quality medical oversight
2:34:20 - The rise in young bodybuilder deaths
2:38:22 - Mr Gay World South Africa
2:42:40 - Was it well received when Noel came out
2:45:03 - Where Noel sees himself in 5 years, the positive impact his platform has had on the industry, and his plans for the future
————————————
📌 Dr. Andrew Huberman's YouTube Channel: https://www.youtube.com/c/AndrewHubermanLab/
————————————
📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
————————————
🕑 Time Stamps:
0:00:00 – Dr. Andrew Huberman Measures My Digit Ratio
0:12:30 – My Secret Last Name, Mike Mentzer's Steroid Advice To Andrew Huberman & Unique Research
0:24:43 – How To Pronounce Turkesterone, Marek Health And Why Blood Work Is Crucial
0:37:47 – How To Fix Your Sleep - Supplements, Importance Of Time You Go To Sleep & Protocols
0:57:09 – Nootropics And The Dark Side Of Curcumin And Health Supplements
1:04:33 – Gyno In The UFC & How Cannabis Actually Affects Hormone Levels
1:18:24 – Peptides & UGL Gear
1:25:05 – QUADRUPLING Of Natural Testosterone Levels Using These Supplements
1:48:20 – Andrew Huberman Describes His TRT Protocol And What Effects He Noticed
2:04:11 – How Much Birth Control Pills CRUSH Female Testosterone Levels & DHEA Supplementation To Spike It
2:10:02 – Pseudohermaphrodites Gaining MULTIPLE Inches In Penis Size & Getting MORE Jacked Than Their Brothers
2:32:58 – TEENS TAKING TREN | Will They PERMANENTLY Alter Their Brain Chemistry?
2:40:48 – Greg Doucette Vs. Andrew Huberman - Calories In Calories Out DOESN'T Work!?
2:53:56 – Andrew Huberman's EXACT Diet And Supplement Routine To Stay Dialed In
3:10:41 – Andrew Huberman's Testosterone Levels After TRT & Ideal Free Testosterone Levels
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💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#moreplatesmoredates #andrewhuberman #podcast
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PsychedSubstance YouTube Channel: https://www.youtube.com/channel/UCn8V3KNSgDr1Dai77_y8JrQ
————————————
🕑 Time Stamps:
0:00:00 - Pysched Substance Reveals Why He Started Steroids
0:09:38 - Psyched Substance's Doctor Calls Me An Idiot And Makes Him Beg For Bloodwork
0:15:22 - Dissecting Psyched Substance's Hypogonadal Blood Work
0:43:29 - His TRT Before And After Effects
0:54:31 - How To Beast & 500 Mg Testosterone Per Week For TRT!?
1:03:33 - Should Psyched Substance Drop His Dose? My Analysis
1:15:03 - Feeling Like SH*T On TRT...
1:28:36 - His Effects On 240 Mg & What Happens To Your Face On Testosterone
1:53:29 - My NIGHTMARE Sleep Schedule
2:14:38 - Spinning Plates
2:29:07 - Fake Girlfriend Challenges & Celebrities Making YouTube Channels
2:35:47 - Pysched Substance Long Term Goals
2:45:26 - Getting Rejected By Girls Wearing $600 Creed Aventus
2:54:09 - Noel Deyzel, Production Value & The Algo
3:14:50 - What I Normally Do On A Work Day From Start To Finish
3:22:36 - GLITCH
3:35:32 - Meeting Subs In Person + Deciding If I Should Microdose
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#MorePlatesMoreDates #PsychedSubstance
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Jo's YouTube Channel: https://www.youtube.com/user/xRaFFniX
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🕑 Time Stamps:
0:00:00 - Joesthetics Talks About Blowing Up On Instagram And Moving From Germany To Thailand
0:10:52 - Thailand Vs Dubai - Jo's Experience Living In Each
0:14:13 - German Women Vs Dubai Women Vs Thailand Women - Joesthetics Explains
0:18:33 - Joesthetics On What Dating Is Like Before And After 4.5 Million Instagram Followers
0:33:18 - The History Of "Alien Gains"
0:38:09 - Jo's 10 Day Get Shredded Protocol, His Training Style & Will He Bulk Again?
0:44:11 - Jo's Peak Natural Physique And How Much Muscle He Gained On Steroids
0:53:49 - Joesthetics FAVORITE Cycle
1:01:55 - Joesthetics Favorite Fat Burning Compounds
1:09:25 - Joesthetics Stay Shredded Year Round Cardio And Diet Regimen Explained
1:17:54 - Joesthetics TOP Fat Loss Tips & Appetite Hacks To Get AND STAY Shredded
1:23:07 - Joesthetics Current Stack, Gyno Removal & Chronic AI Use
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#MorePlatesMoreDates #Joesthetics #JoLindner
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PsychedSubstance YouTube Channel: https://www.youtube.com/channel/UCn8V3KNSgDr1Dai77_y8JrQ
————————————
🕑 Time Stamps:
0:00:00 - PsychedSubstance And MPMD Dissect The Mind Of Connor Murphy
0:23:11 - PsychedSubstance And MPMD React To "RIP Connor Murphy"
0:54:46 - PsychedSubstance And MPMD Discuss The "Amphetamine Recovery Protocol"
0:57:48 - The Truth About Leveling Up Your Character In The Simulation And Becoming "Enlightened"
1:03:42 - How Long Does It Take Your Brain To Fix Itself After A BAD Ayahuasca Trip? (or does it?)
1:06:07 - Will Entrepreneurs Get Wrecked By Psychedelics? - Dopamine RUNNING YOUR LIFE
1:30:48 - Creating MY Psychedelics Protocol!
1:38:08 - Using Psychedelics As A PED In The Gym, In Sports And To Get Shredded
1:50:17 - PsychedSubstance Got JACKED & SHREDDED - Natty Or Not
2:08:30 - TRT Vs. Adderall | PsychedSubstance & MPMD Delve Into Using Testosterone
2:19:20 - PsychedSubstance And MPMD Talk PUA, Cold Approach And The Dating Economy
2:40:31 - Adam's "Asking Strangers To Have Sex" 8 Year Old Viral Cold Approach Video
2:58:06 - PsychedSubstance And MPMD Mega Q&A
4:01:58 - PsychedSubstance And MPMD React To Connor Murphy's Deleted Mental Break Video
4:30:56 - PsychedSubstance Takes DMT LIVE ON THE PODCAST To Show Me Exactly What Happens
4:37:35 - Going Blind And Fighting Demons - PsychedSubstance Tells Me About His WORST TRIP
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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THREADS: https://www.threads.net/@moreplatesmoredates
FACEBOOK: https://www.facebook.com/moreplates/
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TWITTER: https://twitter.com/Derek_Fitness
TIKTOK: https://www.tiktok.com/@moreplates
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#MorePlatesMoreDates #PsychedSubstance
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Firas' YouTube Channel: https://www.youtube.com/user/tristargymcanada
————————————
🕑 Time Stamps:
0:00:00 - Why Firas Thinks Jake Paul Is On PED's And Tyron Woodley Is Natural
0:14:35 - Jake Paul's Hit List
0:22:20 - Firas Zahabi's Official Prediction On Jake Paul Vs Tyron Woodley
0:28:09 - Paulo Costa Vs Marvin Vettori Prediction
0:30:08 - Georges St-Pierre - Natty Or Not
0:48:08 - The REAL Reason Why The GSP Vs Anderson Silva Superfight Never Happened
0:53:56 - Jose Aldo's Sample When He Fought McGregor, Drug Testing Fighters In Different Countries,
0:56:15 - UFC Fighters Cranking Pre And Post-USADA + Costa Vs Adesanya Rematch
1:08:00 - GynoGate
1:12:28 - The UFC "TRT" ABUSE Era
1:20:54 - Steroid Use In BJJ & Can Gordon Ryan Transition To MMA?
1:30:14 - Jake Paul Vs. Logan Paul - Firas Zahabi On Who Wins
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#FirasZahabi #JakePaul #TyronWoodley
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MattDoesFitness' YouTube Channel: https://www.youtube.com/user/MattDoesFitness
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🕑 Time Stamps:
0:00:00 - Intro
0:01:06 - Matt's suspect natty status, and why he wants to get drug tested
0:04:42 - Bloodwork
0:11:12 - People accusing MattDoesFitness using PED's
0:12:00 - WNBF/WADA Testing
0:16:55 - How definitive would these test results be for determining natty status?
0:22:49 - Frequency of testing and why it needs to be completely random
0:28:24 - Matt's physique development over the years and stats
0:38:02 - Matt's physique during his triple jumping days
0:47:50 - Matt's body fat % and DEXA scan results
0:50:13 - Bulking, cutting, and Matt's metabolism
0:55:03 - Matt's stats in University
0:57:13 - Matt says why he has never taken drugs
0:58:48 - Matt's Testosterone levels
1:00:28 - Facial hair and body hair and how much its impacted from Testosterone levels
1:01:56 - Is Matt going to take TRT in the future?
1:05:48 - Matt proposes we subject him to the most rigorous drug testing possible
1:07:00 - Fake natty accusations and the impact on perceptions
1:10:39 - Fake nattys not stepping up to get drug tested
1:11:50 - Testing organizations
1:13:15 - YADA (YouTube Anti-Doping Association)
1:14:33 - Outro
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📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW
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🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order
⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
🧪 Blood Work: https://bit.ly/2wI3k9J
🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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#MorePlatesMoreDates #MattDoesFitness #NattyOrNot
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One Phase 1 study on the SARM RAD140 has been conducted [R].
The Phase 1 trials are the first stage of testing in human subjects designed to assess safety, side effects, best dosage, and formulation method for the drug.
In this podcast episode, I go over the recently published results of that trial.
https://moreplatesmoredates.com/rad140-testolone-review/#rad140_clinical_trials
In a study evaluating dose-response to a moderate and high Anadrol dosage, muscle and strength gains from 50 mg per day and 100 mg per day were compared.
By now you've probably heard me outline the "less is more" concept when it comes to steroid use.
On one side of the spectrum, the clinical data does show that the more steroids you use, the more muscle you will gain over the span of a cycle.
However, the same studies also reveal a dose-dependent decline in muscle growth response relative to increased drug load.
Basically, more works better, but there are diminishing returns the higher your dosages go, and how much muscle you net over the span of your life bodybuilding will likely differ based on how aggressively you approach your mass building phases.
https://youtu.be/JmICCDzhKRo
50 mg Vs. 100 mg Anadrol Study ResultsIn the following study, we can see changes in body weight, lean body mass (what we mainly care about), and fat loss in response to a moderate and high Anadrol dosage (50 mg vs. 100 mg) [R].
The placebo group didn't gain any lean body mass, nor did they lose any body fat.
The 50 mg Anadrol treated group gained 3.3 kilograms of lean body mass and lost 2.6 kg of fat.
The 100 mg Anadrol treated group gained 4.2 kilograms of lean body mass and lost 2.5 kg of fat.
Looking at lean body mass, we can see that when comparing the two dosage groups, the 100 mg group only gained 0.9 kg lean body mass more than the 50 mg group.
This is after three-month exposure to twice the amount of drug.
If we compare biomarkers between the two groups, we can see that the effect 100 mg of Anadrol had on ALT and AST levels was far more deleterious than the 50 mg group.
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are commonly used biomarkers for assessing liver damage.
Placebo 50 mg/day 100 mg/day PValue ALT, U/l 0 ± 2 21 ± 15 72 ± 67 0.001 AST, U/l 1 ± 2 14 ± 6 38 ± 29The anabolic steroid family tree is a framework that simplifies how different steroids impact muscle building and performance.
In general, the most commonly used anabolic steroids fall into one of three different families/categories.
Testosterone and its derivatives, Dihydrotestosterone (DHT) and its derivatives, and Nandrolone (19-Nortestosterone) and its derivatives.
Expectedly, many of the anabolic steroids in each family have similar attributes to one another.
There are exceptions to this in each family, but in general breaking down anabolic steroids into the three families provides a simplified framework to identify the targeted action of each compound, as well as how they impact muscle building and overall performance.
Gorilla Mode Nitric Pre-Workout is the most potent and comprehensive stimulant free pre-workout on the market in ALL aspects.
All angles of saturating the muscle with blood and hydration have been addressed in this formula and are quite literally maxed out.
https://youtu.be/iFlmwQXBs6U
Gorilla Mode Nitric Supplement FactsPer Full Daily Dose:
This is the most maxed out stimulant free pre-workout formula on the market in all aspects.
It is also the most comprehensive formula that targets nitric oxide (NO), vasodilation and intracellular hyper-hydration from multiple angles, while maintaining top end dosages across all of those pathways.
We completely saturate the traditional Arginine–eNOS–nitric oxide (NO) pathway with a massive 10 gram dose of L-Citrulline, 1.5 grams of Nitrosigine and 1.5 grams of Agmatine Sulfate.
The often neglected nitrate–nitrite–nitric oxide (NO) pathway is also topped out with a 1500 mg dose of Sodium Nitrate.
A high level of intracellular hyper-hydration is achieved with 5 grams of Creatine Monohydrate, 4 grams of Glycerpump and 4 grams of Betaine Anhydrous.
We also addressed the enzyme angiotensin converting enzyme (ACE) with VasoDrive-AP®, which acts as an ACE inhibitor and significantly increases vasodilation.
Finally, we have 3 grams of Malic Acid added in on top of the 10 grams of pure L-Citrulline to act as a Krebs cycle intermediary and counter lactic acid buildup during training.
Some of these pathways are so maxed out that we could have easily just chosen one of them and sold the product for $39.99 and still had one of the most potent pre-workouts in the industry.
Instead, I packed it all into one absurd product that clocks in with over 30 grams of efficacious active ingredients per full dose.
It was incredibly expensive to create, but I am very happy with how it turned out, and I am not exaggerating when I say that this pre-workout is absolutely unmatched.
Basically, I just included exactly what I would want to see in a stimulant free pre-workout, even at the obvious detriment of our margins.
This product is even more potent than Gorilla Mode when it comes to pure pump and performance.
The full daily dose is 2 scoops.
Even a half dose (1 scoop) is still far more potent than the majority of other pre-workouts out there at their max dosages.
This is another product I wanted to be head and shoulders, clear as day, superior to everything else in the industry.
Just like in my description of how Gorilla Mode stacks up to other products in this industry, we can actually back up why our product is better than the rest.
When (insert fitness influencer name here) launches their own supplement line, they will regurgitate the same story about how their products are effectively dosed, only use the highest quality ingredients, blah blah blah.
They don't even know what they're selling half the time, let alone what combinations of ingredients work synergistically, or how to dose a product properly.
They employ others to manufacture their products, or use a pre-made formula their manufacturer uses for every company where they just slap a different label on it and sell it for a huge margin.
At the end of the day, most fitness influencers have no idea what goes into making an effective product.
They don't know how their products work, they probably wouldn’t even use them if they didn’t sell them, they didn't formulate them, and they have to pay the overhead involved with having a team under them who is responsible for all of that.
As you’ve already experienced with Gorilla Mode and Gorilla Mind Nootropics, it is me formulating the products, and they work because I actually put in them what I would want in a product and buy myself if I didn’t have a company.
The same applies with Gorilla Mode Nitric.
If I didn’t have this product, for an effective stim-free pre-workout I would probably be mixing up 6000-10,000 mg of L-Citrulline for vasodilation (with 6000 mg being the bare minimum of pure L-Citrulline, not Citrulline Malate, and would be dependent on my budget at the time), a saturation dose of Creatine Monohydrate (5000 mg), 3000-4000 mg of Glycerpump to hyper-hydrate the muscle with water, and maybe a quarter teaspoon of Himalayan Pink Salt.
The fact that a significant amount of supplement companies will skimp out on Creatine Monohydrate and either not include it at all, or only include a subpar dosage, really sheds light on how scammy this industry can be.
That is the cheapest ingredient they could easily dose properly, and even that they won't shell out the money for in their formulas.
It’s not hard to put 5 grams of Creatine in a pre-workout, and it is actually pretty cheap to put in there.
The reason is, they want you to go buy their creatine product, and will intentionally manipulate their ingredient profile to be deficient in several areas to make you buy more stuff from them.
With my products, everything is turnkey.
You don’t need to go buy a separate Creatine product from us, you don’t need to stack extra stims on top of our stim-based products, you don’t need to go buy something else to get the max dose of a certain ingredient in any of our formulas, everything you need is in each product at an efficacious dosage.
Flavor And MixabilityThe flavor we chose to start with for Nitric was Mango Peach as it is a more mainstream appealing flavor than Tiger's Blood.
Tiger's Blood and a fruit punch flavor will probably be next in the pipeline of flavor releases.
Mango Peach is easily a 9 or 10/10 flavor, even for the pickiest of tongues.
As there’s such a high concentration of ingredients in this formula we were really happy with how the flavor systems turned out.
We were expecting something this potent to be nearly impossible to avoid tasting like ass.
Fortunately, that wasn’t the case.
It also mixes very well considering the concentration of L-Citrulline, GlycerPump, and all of the other ingredients in this product.
There is some grittiness, but that just comes with the territory with putting out a 35 gram serving size product with 10 grams of L-Citrulline and 4 grams of Glycerpump.
You will just have to use a bit more water than you would with your standard pre-workout because there are simply more active ingredients in this product that will require more liquid to mix well.
How To Dose Gorilla Mode NitricMix 1-2 scoops of Gorilla Mode Nitric in 12-14 ounces of water and consume 30 minutes prior to training.
Vary the amount of water to achieve your desired flavor level.
First time users should begin use with 1/2-1 scoop or less to evaluate tolerance.
DO NOT EXCEED 2 SCOOPS IN ANY 24 HOUR PERIOD.
Gorilla Mode Nitric Ingredients Breakdown L-Citrulline – 10,000 mgL-Citrulline is the most effective supplement you can use to boost nitric oxide (NO) in the body.
Why Nitric Oxide (NO) Is ImportantNitric oxide (NO) is made naturally in our bodies and plays a significant role in cardiovascular health.
It dilates blood vessels (vasodilation), which lowers blood pressure and increases oxygen in the blood.
https://youtu.be/EoYhQIHmKoE
Nitric oxide (NO) acts as a messenger to signal blood vessels to dilate, or contract and relax.
Sufficient nitric oxide is needed to signal blood vessels to contract or relax to ensure blood is able to flow to and from the heart effectively.
Nitric oxide production decreases with age, consequently reducing the elasticity of the cardiovascular system, and impairing the body's ability to ensure sufficient amounts of oxygenated blood are reaching vital organs.
Eating enough nitrates and/or supplementing with nitric oxide precursors is very important to ensure that your cardiovascular system maintains optimized function as you get older.
In addition, maintaining optimal nitric oxide levels will make you more vascular, allow you to get a much better pump, increase muscle volume, enhance the delivery of oxygen and nutrients to working muscles, support recovery and improve overall physical performance.
Increased Muscular EnduranceCitrulline has also shown to significantly increase muscular endurance, with one study finding that compared to placebo, a single 8000 mg dose of Citrulline Malate increased the number of reps performed per set, on every set after set 2 [R].
The impact Citrulline had on performance increased the more sets were performed.
During the last set performed, the group that took Citrulline had a 52.92% increase in the number of reps they could perform relative to placebo.
It also decreased muscle soreness by 40% at 24 and 48 hours after the training session compared to placebo.
Effect On Body CompositionThere isn’t much data on the direct effect Citrulline has on muscle growth and fat loss in humans.
However, a rodent model assessed the effect Citrulline had on body composition and found that 20 month old rats that were given a diet that included the human equivalent dose of 160 mg/kg per day for 12 weeks had 13% less body fat and 9% more lean body mass relative to the rats fed a standard diet without Citrulline supplementation [R].
Visceral fat mass was also reduced by 32%.
The mortality rate of the rats taking Citrulline was 0%, while the standard diet fed rats had a mortality rate of 20%.
L-Citrulline is one of the most promising supplements on the market and has significantly more upside above and beyond its increase in vascularity and pumps in the gym.
The Maximum Effective Dose Of L-CitrullineCitrulline is found in watermelons.
You would need to eat 1.5 kg of watermelon every day to get 3 grams of L-Citrulline though, which is the minimum effective dose [R].
To get the maximum effective dose of L-Citrulline from your diet, you would need to eat 5.0 kg of watermelon per day to get 10 grams (10,000 mg) of L-Citrulline [R].
Obviously, nobody is going to eat that much watermelon, nor is it a good idea to begin with in my opinion when there are far better ways to allocate your macronutrient/micronutrient intake allotments.
This is why L-Citrulline supplementation could actually be worthwhile.
The Problem With Citrulline Malate In The Supplement IndustryWhile L-Citrulline is a great supplement to have in your daily regimen, there is a red flag around L-Citrulline supplementation that you need to know about.
I'm sure you've seen that some supplements have L-Citrulline in them, and some have Citrulline Malate.
Some even say "L-Citrulline Malate".
This is a cheap trick companies use to deceive customers.
Citrulline Malate is composed of 50% Malic Acid, unless the ratio states otherwise.
Authentic Citrulline Malate is produced by chemically bonding free-form L-Citrulline to DL-Malic Acid.
When L-Citrulline is chemically bonded to DL-Malic Acid, the end result is Citrulline Malate, which has unique properties.
But the problem with the Citrulline Malate in the supplement industry is that it doesn't have this chemical reaction.
It's just Citrulline mixed with malic acid in a big mixing vat in the manufacturing facility.
There is no chemical bond like there should be to create authentic Citrulline Malate.
It's just the two ingredients being mixed together in a cheap blend, and it's sold as "Citrulline Malate", or "L-Citrulline Malate".
The reality is that it's just Citrulline stirred up with malic acid.
While this isn't a huge deal in itself, the problem lies in the labeling practices companies use to artificially inflate the perceived potency of their product.
6-8 grams is seen as the max clinically proven efficacious dosage in the supplement industry in general.
At least, that's what companies will tell you in their marketing.
First of all, we already know that the actual maximum efficacious dosage of L-Citrulline is 10 grams per day [R]. In addition, the main issue is that the "L-Citrulline" in their product is actually as low as half of the stated label claim.
As mentioned, Citrulline Malate is just a mixture of Citrulline and malic acid.
Somehow, companies are getting away with labeling their products with the chemically bonded form Citrulline Malate and claiming they have 6-8 grams per serving in their pre-workout, when they actually just have 3-4 grams of Citrulline and 3-4 grams of malic acid per serving.
Instead of labeling the following:
These companies are labeling their products like this:
Or like this:
Making you think you are getting a high dose, when in reality you are getting the bare minimum efficacious dose per serving of 3 grams.
Sometimes, companies will tweak the ratio to be a bit more in favor of a higher Citrulline content relative to malic acid, but this is rarely higher than a 2:1 ratio.
So, if you see the following:
That just means that the company has 4 grams of L-Citrulline and 2 grams of malic acid per serving.
This is the exact manufacturing process involved in producing the L-Citrulline and "Citrulline Malate" you get in pre-workouts in the supplement industry: As you can see, the Citrulline Malate manufacturing flowchart on the right literally just says, "mix".
If this was authentic Citrulline Malate, you wouldn't need to mix L-Citrulline with malic acid, it would be chemically bonded together by the end of the manufacturing process.
You're not really getting what you're paying for, and most don't realize this is a tactic in the industry to get better margins and artificially inflate a products perceived efficacy.
Even if a pre-workout had what on paper appears to be a top end efficacious dose of 8 grams per serving, how much L-Citrulline are you actually getting out of that serving?
4-6 grams at most.
I have yet to see a pre-workout formula actually hit a top end L-Citrulline dosage, and of the ones that get close, they use Citrulline Malate to inflate their label.
In addition, even if you had the bonded version (which supplements don't), reacted Citrulline Malate will break apart into L-Citrulline and malic acid right away after its mixed in water.
It's all just a trick to artificially inflate a products perceived potency on a label, as each ingredient should be listed separately.
Most supplements have malic acid anyways in the "other ingredients" section, which is still an active ingredient that does have some potential performance benefits that you would get from the “Malate” portion of Citrulline Malate.
L-Citrulline and malic acid work via a different mechanism of action.
Citrulline bypasses the liver and gets converted to arginine, which increases NO levels in the body.
Malic acid is a Krebs cycle intermediary that counters lactic acid buildup.
How much do you need of each though?
With Citrulline, we know where the top end data lies.
Malic acid, we don't.
There is research on Citrulline and Citrulline Malate, but not much data on supplementing with malic acid to replenish depleted levels as a Krebs cycle intermediary.
I don't think we can make a generalized overview on how effective the malic acid component was in the Citrulline Malate research either because we can't determine if the results were derived from the malic acid, the L-Citrulline, or both.
Considering this, I included an additional 3000 mg of malic acid separately in the Gorilla Mode Nitric formula as an active ingredient in the main ingredients panel.
As mentioned, malic acid is most commonly used as a filler in supplements, and will be found in small amounts in many product "other ingredients" sections.
The only other time it is used is by companies artificially inflating their perceived L-Citrulline dosage via Citrulline Malate.
No companies are including a maxed out dose of pure L-Citrulline as well as malic acid separetely though.
It is always a subpar amount of each.
So, if there is some sort of performance enhancing benefit to having a high dose of malic acid, you are also getting it via Nitric on top of the maximum efficacious 10,000 mg dose of pure L-Citrulline.
At the end of the day, for vasodilation you should concern yourself with is how much pure L-Citrulline is in your pre-workout supplement.
I have yet to see a product with more than 6000 mg of PURE L-Citrulline.
I have only seen a handful of products with 6 grams of L-Citrulline, and another handful of products with 8 grams of Citrulline Malate (which only yields 4-5 grams of actual L-Citrulline, with the remainder as malic acid).
I put 10 grams of PURE L-Citrulline in Gorilla Mode Nitric, as well as 3 grams of malic acid separately, so you can get the full benefits of the max dosage of each ingredient and transparently see exactly what you are actually getting in the product.
Even if you decide to only use a half dose of this product you will still get 5000 mg of pure L-Citrulline, and the formula is still top notch even when cut in half.
Citrulline Vs ArginineOne of the most well-known pump ingredients is Arginine.
The problem with L-Arginine is that it is very ineffective at increasing Nitric Oxide synthesis.
Logically, you would assume that taking Arginine would be the most effective way to increase Arginine levels in the body.
However, this is not the case.
Oral L-Arginine is taken up and metabolized by the liver so much that it does not actually effectively increase Arginine levels, and it may even be unsafe to use because of how much excessive urea it yields [R].
L-Citrulline bypasses the liver and passes freely to the kidneys where it is metabolized to Arginine [R].
The most effective supplement that can be used to increase Arginine levels in the body to improve cardiovascular and metabolic health outcomes is L-Citrulline [R].
L-Citrulline supplementation has shown to lower blood pressure and provide atherogenic-endothelial protection [R].
When it comes to NO precursors that significantly improve pumps, nothing beats an efficacious dose of pure L-Citrulline.
Creatine Monohydrate – 5000 mgCreatine is the best studied and most effective performance enhancing supplement outside of exogenous hormones and drugs.
Creatine’s Effect On Muscle Size And StrengthSupplementing with creatine has shown time and time again to significantly improve strength, power output and muscle size [R].
Creatine’s effect on strength is facilitated by increasing the body’s stores of phosphocreatine, which is then used during high intensity exercise to produce ATP [R, R].
Creatine’s effect on muscle size is facilitated by drawing water into the muscle via osmosis, consequently increasing body weight and muscle size.
In addition, with the increased strength creatine provides, heavier weights can be used in the gym which provide more stimulus for growth, consequently increasing muscle accrual in the long-term.
Creatine supplementation also appears to increase the number of myonuclei that satellite cells will donate to damaged muscle fibers, which increases the potential for growth of those fibers [R].
A typical omnivorous diet provides about 1 gram of creatine per day, which isn’t enough to get the benefits you would from supplementation, and also isn’t nearly enough to support health status and methylation in those with genetic polymorphisms.
Creatine’s Effect On Methylation And Health StatusAbout 1 gram of creatine is endogenously produced in the body naturally in young healthy adults [R].
Most of the human body's total creatine and phosphocreatine stores are found in skeletal muscle, while the remainder is distributed in the blood, brain, and other tissues [R].
While there are a host of processes in the body that rely on creatine to be carried out optimally (and are often completely neglected), one of the most notable functions of creatine is neurological support [R].
In addition, the endogenous synthesis of creatine relies on a process called methylation.
Arginine and Glycine are combined by an enzyme to form guanidinoacetate, which is then methylated into creatine.
The problem is that this process is dependent on a mechanism of action that is commonly inhibited in the general population via endogenous Arginine deficiency, Glycine deficiency, or MTHFR polymorphisms.
The MTHFR gene codes for an enzyme called methylenetetrahydrofolate reductase or MTHFR.
This enzyme is needed for the production of DNA and methylation pathways that are essential for all bodily functions.
Genetic variations in this gene results in reduced activity of the enzyme and has been associated with cardiovascular disease, neurological defects, some forms of cancer, and a myriad of other diseases and disorders [R, R].
Personally, I am homozygous for C677T of MTHFR, which results in a 80-90% decrease in my efficiency in processing folic acid.
The direct reflection of that in blood biomarkers can be high homocysteine and low B12 and folate levels.
I determined this via a simple 23andMe genetics test.
Upwards of 45% of your body’s methylation demands are used to synthesize creatine.
For someone with a MTHFR polymorphism, you can put a significant amount of stress on your methylation pathway and deplete far more methyl groups than you should be just to create the 1 gram per day that you endogenously synthesize.
We lose up to 2-3 grams of creatine per day because it converts to creatinine and is then passed out of the body via urine.
As you can see, adequate replenishment of creatine is probably not being accomplished if you aren’t consistently eating a fair bit of meat or fish.
And for those with impaired methylation pathways, supplementing with exogenous creatine is likely the only way creatine replenishment can be achieved.
One study found that supplementing with 5 grams of creatine per day lowered plasma homocysteine levels by almost 50% in the subject who is homozygous for C677T of MTHFR [R].
Creatine supplementation can significantly lower the body’s demands for methylation and prevent the depletion of methyl groups.
This is why I personally supplement with 5 grams of creatine per day.
Do You Need To Cycle Off Of Creatine?No, you do not need to cycle off of creatine.
Your body does not get used to it, and long-term use has shown to be safe in healthy adults [R].
Betaine Anhydrous – 4000 mgBetaine, also called Trimethylglycine, acts as a methyl donor and an osmolyte in the body.
Earlier in the creatine breakdown, I briefly outlined the importance of having a sufficient amount of methyl donors available for methylation processes in the body, including the endogenous synthesis of creatine.
For some individuals (depending on PEMT gene variations) Betaine can substitute for folate and B12 in the regeneration of methionine and can be choline sparing via this mechanism.
It can also provide additional needed methyl donors when over-depletion occurs in genetically predisposed individuals that do not supplement with creatine, or have other deficiencies.
As an osmolyte, Betaine helps balance fluid levels inside and outside of cells.
The main reason I included Betaine in this formula is for its ability to induce intracellular hyper-hydration.
By improving hydration status in cells, Betaine increases the pump you get in the gym, and can help prevent dehydration during exercise.
Research has also shown that Betaine supplementation may reduce the risk of cardiovascular disease, as well as improve digestion and liver function [R, R, R, R].
In a performance enhancing context, Betaine supplementation has also shown to increase power, endurance, muscle growth and fat loss [R, R, R].
How significant will this effect on body composition be in practical application?
Negligible in my honest opinion, but the enhanced pump made this ingredient worthwhile to add into the formula.
GlycerPump™ (65% Glycerol Powder) – 4000 mgGlycerol significantly enhances pumps and performance by hyper-hydrating the muscle with water.
Glycerol’s Effect On Hydration, Pumps And EnduranceIf you drink a lot of water with nothing else in hopes of hyper-hydrating your muscles, the fall in osmolarity in your body stimulates the kidneys to remove most of the excess water within an hour.
If you add glycerol to the water, this prevents the drop in osmolarity and can extend the hyper-hydration of your muscles by up to four hours.
By adding Glycerol to your pre-workout, you can hold upwards of an extra liter of water via this hyper-hydrating effect.
Hydration is one of the most critical factors when it comes to performance.
Aside from massive pumps, Glycerol use has shown to increase endurance by as much as 24%, as well as improve aerobic and anaerobic power and performance [R, R].
Only a 2% loss in fluids can result in as much as a 20% decrease in exercise performance.
GlycerPump™ Vs Other Forms Of GlycerolWe chose the trademarked GlycerPump because it doesn’t clump up nearly as much as other forms of Glycerol powder and it’s more stable.
Glycerol is normally a liquid at standard temperature and pressure, and many supplement companies have attempted to create a powder form of Glycerol that is stable.
Glycerol products get clumpy, have horrible viscosity and have a short shelf life.
Because of this, most companies avoid this ingredient entirely, as it can cause severe clumping within just a couple months of being manufactured.
Regular glycerol containing products only yield as low as 10% glycerol, which makes them ineffective, and higher yielding glycerol products can be unstable within complex formulas like ours and result in a clumpy product, or complete product failure.
GlycerPump™ is created using unique spray drying technology, yielding a stable powder form of glycerol standardized to 65%.
It is MUCH better than other alternatives and won't result in the powder turning into a rock.
Keep in mind, while it is manageable, this is not a clump-free product, and there’s nothing I could do about that if I wanted to include the high concentration of ingredients that I did in Gorilla Mode Nitric.
Store Gorilla Mode Nitric in a cool dry place, and if it clumps, that’s just what comes with the territory with a product dosed like this.
If it clumps, just get out a knife or spoon and chop it up, and it will still mix fine once it hits the water in your cup.
Agmatine Sulfate – 1500 mgAgmatine has shown to induce NO production via the same processes as arginine, but does it far more effectively [R].
This results in even bigger pumps in the gym and improved overall performance.
Agmatine has also shown to be neuroprotective against excitotoxicity and stroke, and also has anti-anxiety and anti-depressant effects that may enhance state of well-being and mood elevation with supplementation.
Agmatine has also shown to manipulate pain receptors, which may result in an increased pain tolerance during intense training.
Agmatine is a very misunderstood compound and is believed by some to antagonize other vasodilators.
Agmatine works in a more selective way than other vasodilators, as it only increases one of the three Nitric oxide synthase (NOS) isoforms.
It also decreases the other two NOS isoforms, which is where the hypothesis about it being vasoconstricting was raised as a legitimate concern.
The three NOS isoforms include iNOS, nNOS and eNOS.
They each play their own role in certain tissues to regulate vasodilation.
eNOS is the main isoform that most are familiar with that increases blood flow and lowers blood pressure.
It is also the main isoform that facilitates massive pumps in the gym.
While NO is great for the gym and vascular health, it can be inflammatory in excess.
NO production by eNOS has shown to play a protective role in cerebral ischemia by maintaining vascular permeability, whereas NO derived from nNOS and iNOS is neurotoxic and can enhance the neuronal damage occurring in ischemia [R].
This is where the selective activity of Agmatine shines, as data suggests that Agmatine's mechanism of action is facilitated by inhibiting iNOS and nNOS and increasing eNOS [R, R].
Agmatine has shown to selectively increase eNOS levels while simultaneously decreasing iNOS and MMP-9 protein expression [R, R].
Anecdotally, Agmatine does not seem to inhibit any of the positive effects of L-Citrulline or other vasodilators.
On the contrary, it seems to complement other "pump" compounds very effectively.
On paper, Agmatine sounds like the perfect ancillary compound to add to a pre-workout as it increases expression of the NOS isoform we want, while simultaneously inhibiting the isoforms that can be more inflammatory in excess.
Nitrosigine® (inositol-stabilized arginine silicate) – 1500 mgNitrosigine got some hype behind it when independent researchers from the University of Arkansas presented data suggesting that 1500 mg of Nitrosigine was almost as effective as 8000 mg of Citrulline Malate 2:1 (5333.33 mg L-Citrulline and 2666.66 mg Malic Acid) at increasing flow mediated dilation (FMD) [R].
FMD refers to dilation of an artery when blood flow increases in that artery.
Because the primary cause of FMD is release of nitric oxide by endothelial cells, we can use FMD as a proxy for NO levels.
To circumvent the lackluster efficacy of plain oral Arginine, Nutrition 21 (the developers of Nitrosigine) created a complex of bonded arginine and silicon.
The inositol acts as a stabilizer and increases the bioavailability of the complex, consequently resulting in a potent NO boosting compound.
Remember that the main issue with Arginine is poor bioavailability.
The inositol stabilizer helps circumvent that issue [R].
Unlike plain Arginine, Inositol-stabilized Arginine silicate (Nitrosigine) has shown to kick in within 15 minutes and elevate blood Arginine levels for up to six hours after ingestion [R, R].
Nitrosigine has some impressive data reinforcing its efficacy, and it is purported to be much more effective milligram for milligram than other common vasodilators at increasing NO levels.
On top of the increase in vasodilation and pumps, the developers claim that after a single dose Nitrosigine can increase mental acuity and focus by 33% within 15 minutes, with a compounding effect over time.
In addition, they claim that Nitrosigine supports enhanced recovery by reducing markers of muscle damage [R].
Nitrosigine Vs. L-Citrulline Vs. Agmatine Sulfate In VitroAn in vitro study was designed by Nutrition 21 to compare the cellular production of NO of several sports nutrition ingredients.
These ingredients included Nitrosigine, L-Arginine, L-Arginine AKG, L-Citrulline, Citrulline Malate and Agmatine Sulfate.
Nitrosigine was dosed at a concentration of 1.0 g/L.
Cell culture concentrations of the other compounds were dosed relative to a 1500 mg dose of Nitrosigine using the following doses:
As NO is unstable and rapidly converts to nitrites or nitrates, nitrite levels were measured as a proxy for NO production.
At the doses used in this study, Nitrosigine significantly increased NO production over each of the five other compounds tested.
There was a greater than 5X increase in NO production with Nitrosigine compared to the other tested vasodilators.
In addition, of the compounds tested, only Nitrosigine significantly increased NO production versus control.
While this looks very impressive for Nitrosigine, you have to consider that this is an in vitro study conducted by Nutrition 21 themselves.
The results basically indicate that every single clinically proven vasodilator that we know works is useless as it couldn't increase NO production above control, meanwhile Nitrosigine somehow cranked it through the roof over 5x higher than the rest.
While the results are certainly interesting, I would take this data with a grain of salt.
Nitrosigine Vs. Citrulline Malate - Vasodilation Study On Young AdultsUnlike the in vitro study comparing Nitrosigine to Citrulline Malate, another study in 2019 was apparently conducted independently from the company without their knowledge whatsoever [R].
This study was conducted on young, healthy, physically active adults, and provides more acceptable parameters for us to take seriously when it comes to evaluating Nitrosigine's efficacy in humans relative to a decent dose of the most widely used vasodilator in the industry, Citrulline Malate (assuming that the study was actually unbiased as is implied) [R].
16 healthy young men and 8 healthy young women participated in the study.
Each subject either received 1500 mg of Nitrosigine, 8000 mg of Citrulline Malate 2:1, or dextrose placebo.
Keep in mind, this is Citrulline Malate 2:1, so the subjects are only actually getting 5333.33 mg of L-Citrulline.
The study was randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period.
Baseline flow mediated dilation (FMD) measurement was obtained for each visit, followed by consumption of one clinical dose Citrulline Malate (8 grams), Nitrosigine (1.5 grams), or dextrose placebo (8 g).
Following a 60-min digestion period, FMD was repeated.
Supplementation order was randomized controlling for potential order effects.
Basically, the subjects would show up, get their FMD evaluated, take one of the three options, and then get their FMD checked again to see how well the random compound they ingested increased their NO production.
They would then take a week off, and come back and repeat, where they would then receive one of the remaining two compounds, with the same measurement process.
This would be followed by another week off, and then a third visit where the subjects would receive whatever the third ingredient was that they hadn't yet tried, and the same measurement process was conducted.
Nobody knew what they were ingesting during each trip, but by the end of the experiment every single subject had tried each ingredient, and their vasodilation response was evaluated for comparisons.
Expectedly, Citrulline Malate and Nitrosigine yielded a greater improvement in FMD response than placebo.
Citrulline Malate increased FMD by 34%.
Nitrosigine increased FMD by 31%.
Placebo decreased FMD by 2%.
Allometric scaling of the FMD values was required afterwards to adjust the results to account for the body size of males relative to females.
After allometric scaling of the FMD values, Citrulline Malate was shown to increase FMD by 25%, Nitrosigine increased FMD by 23%, and placebo increased FMD by 0.6%.
Clearly Citrulline Malate isn't as useless as the Nutrition 21 funded in vitro data would lead you to believe.
The results from this study suggest that the clinically efficacious 1500 mg dose of Nitrosigine is almost equally effective to 5333.33 mg of L-Citrulline mixed with 2666.66 mg of Malic Acid.
Clearly Nitrosigine has a lot of promise as a pre-workout ingredient, which is why I included it in our formula alongside the massive dosages of other potent vasodilators we already have.
Every single effective vasodilator we felt was worthwhile is in here at topped out dosages.
While it would be nice if there was data we could refer to evaluating if there is a synergy between Nitrosigine and Citrulline, or Nitrosigine and Agmatine, regardless if the end result is 1+1 = 2 or if it's 1+1 = 3, my goal was to make sure this formula was air tight and ensure you are getting the maximum possible performance enhancing benefit from each and every ingredient.
Sodium Nitrate – 1500 mgSodium is one of the most critical and overlooked components of a diet designed to optimize exercise performance.
But, keep in mind, you’re not going to get enough sodium in a pre-workout without it tasting terrible.
Other companies will put a tiny dose of sodium in their product and then claim you will get all of the benefits of it.
Personally, I just toss and wash a quarter teaspoon of a high quality salt 30 minutes pre-workout with Gorilla Mode or Gorilla Mode Nitric, and I take another quarter teaspoon with my post-workout drink.
The reason I included sodium nitrate in Gorilla Mode Nitric is not for the sodium, it is for the nitrates.
The nitrate–nitrite–nitric oxide (NO) pathway is a series of oxygen-independent and NO synthase–independent single-electron transfer reactions that ultimately facilitate vasodilation.
The traditional Arginine–eNOS–nitric oxide (NO) pathway is what most NO precursors focus on.
The nitrate–nitrite–nitric oxide (NO) pathway often goes completely neglected though, and is another pathway we can leverage to amplify NO levels to an even greater level.
Nitrates found in food can be converted into nitrites in the body, and then reduced to NO via nitrite reductase [R].
Several studies have shown that nitrate supplementation can increase plasma nitrite concentrations, and consequently Nitric Oxide, which then enhances pumps, endurance, and all of the other benefits we use NO precursors for [R].
Nitrate Dosage - Sodium Nitrate Vs. Beet Root Powder Pre-WorkoutsBeet root is a very popular ingredient that has started to get a lot of attention over the past few years.
The reason why beet root works is because it is a densely concentrated source of nitrates.
However, despite it being densely concentrated relative to other foods, beet root still only contains 1-2 percent of nitrates per gram of raw material.
This would require you to ingest an absurdly high amount of beet root to get the same amount of nitrates that you can get from the 1500 mg of sodium nitrate in Gorilla Mode Nitric.
To put it in perspective, your standard beet root powder pre-workout supplement has around 4.3 grams of Beet root juice powder in it.
The amount of nitrates in that 4.3 grams is about 43 mg.
That means that you would need to chug the entire tub at one time to get the same amount of nitrate as you would get out of a 1500 mg dose of sodium nitrate.
There is no feasible way to get a high dose of nitrates from beet root powder without ingesting massive quantities far higher than what you would get in a dietary supplement.
By weight, sodium nitrate is the most highly concentrated source of nitrates among any dietary ingredient.
Nitrates comprise 73 percent of the total weight of sodium nitrate [R].
The optimal dosage of nitrate supplementation appears to be between 6.4-12.8 mg/kg [R].
That equates to the following dosage protocols:
For every gram of sodium nitrate, 730 mg is from nitrate.
The 1.5 grams of sodium nitrate in Gorilla Mode Nitric yields 1095 mg of nitrate.
There are other nitrate based supplements in the industry like Arginine Nitrate, Creatine Nitrate, Betaine Nitrate that operate via this same nitrate–nitrite–nitric oxide (NO) pathway, however, none of them have as high of a nitrate composition gram for gram as Sodium Nitrate does.
VasoDrive-AP® (isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) isolated from hydrolyzed milk casein) – 254 mgVasoDrive-AP consists of 2 lactotripeptides: isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) which are clinically proven to inhibit Angiotensin converting enzyme (ACE) and significantly increases vasodilation.
Angiotensin converting enzyme (ACE) controls blood pressure by regulating the volume of fluids in the body.
ACE facilitates this process by converting the hormone angiotensin I to the active vasoconstrictor angiotensin II.
Angiotensin converting enzyme inhibitors (ACE inhibitors) inhibit ACE, consequently reducing angiotensin II production.
Reducing angiotensin II results in the dilation of blood vessels and a reduction of blood pressure.
Bradykinin is also a vasodilator in the body that is degraded by ACE.
Clinical data suggests that individuals who genetically have lower levels of ACE respond better to training and are at an advantage in endurance sporting events [R, R].
The more blood flow you have, presumably the more oxygen and nutrient carrying capacity you will have during exercise.
VasoDrive-AP has shown in 30 clinical studies to date a potent effect on vasodilation and blood pressure reduction via this mechanism completely independent from the traditional Arginine–eNOS–nitric oxide (NO) pathway [R].
Ingredients I Didn’t Include In The Formula And Why Vitamin CVitamin C is a very potent antioxidant and plays a crucial role in lowering blood pressure and regulating health blood flow.
Supplementing a Vitamin C deficient diet can be very beneficial, except when you're dosing it pre-workout.
Vitamin C is inexpensive and has tons of clinical data to back its efficacy, so it is often thrown in pre-workouts.
The problem with this is that using Vitamin C pre-workout can blunt the hormetic response to the workout itself and hinder your results [R].
The point of working out is to damage the muscle, which then results in the body signaling repair processes to start that will help you recover and ultimately get bigger and stronger to adapt to the workload.
If you manually decrease that hormetic response to exercise by ingesting Vitamin C pre-workout, you will reduce the damage done and ultimately prevent your body from stimulating as much growth.
Personally, I don't take any vitamins, anti inflammatories, or powerful antioxidants for several hours before or after my workout to be safe.
Antioxidants And VitaminsAs mentioned, one of the worst things you can do is take antioxidants before your workout.
The stress and damage induced by weightlifting or exercise is needed to facilitate muscular recovery and progress.
The reactive oxygen species and inflammation produced during intense training assists with that process, and is also why drugs like Ibuprofen can inhibit muscle growth so severely.
The inflammatory response to training is what we want in order to recover, and by inhibiting that with antioxidants, vitamins or anti-inflammatory drugs, you prevent your body from breaking down and recovering the way it needs to in order to grow [R, R].
A pre-workout formula with a bunch of vitamins and antioxidants in it is more likely to hinder your gains than help.
PotassiumI advise reaching your recommended daily intake of 4,700 mg through diet rather than through supplementation.
It is not legal to sell Potassium in high amounts, and you will usually find that supplements have no more than 100 mg or so per serving because of this.
For this same reason, supplementation isn't cost effective, and pre-workouts with potassium in them are including it solely to claim the benefits of potassium all the while knowing the dose in their product is next to useless.
The amount of potassium in pre-workout supplements does next to nothing for you when it comes to helping you hit the RDA.
S7™S7™ is a blend of green coffee bean extract, green tea extract, turmeric extract, tart cherry, blueberry, broccoli and kale that has gotten some hype in pre-workouts recently.
I was considering including it in our formula until I saw that the blend was comprised entirely of potent antioxidants and anti-inflammatories.
Turmeric is one of the most potent anti-inflammatory spices known to man, which is why it also shows such therapeutic promise via supplementation.
However, the last thing you want to use pre-workout is a potent anti-inflammatory compound.
Inflammation is what we are striving for during a workout, and using anything that significantly impairs this inflammatory response to training is something that should not be used pre-workout, and should be saved for taking far away from the peri-workout window.
Beta AlanineBeta Alanine is the ingredient that makes your skin itchy and has you sitting there scratching your face between sets.
I assume it is included in pre-workouts because you can blatantly feel something when you take it, so people associate feeling something with the product being potent.
Personally, I can’t stand the itchy skin effect it has, and it can be bad enough that it ruins a pre-workout just based on that.
In addition, it doesn’t have more than a negligible effect on performance at best.
Acute sporadic bumps in Beta Alanine will do next to nothing if you are only getting your Beta Alanine dosage from your pre workout supplement a few times per week.
If you were to take it correctly, dosing it multiple times per day, for weeks on end, at a high enough dosage, the impact on performance is notable, although still fairly insignificant at the end of the day.
“The median effect of β-alanine supplementation is a 2.85% (-0.37 to 10.49%) improvement in the outcome of an exercise measure, when a median total of 179 g of β-alanine is supplemented” [R].
179 grams (an amount nobody would end up getting in) for a 2.85% improvement in performance, and a ton of itchiness…
“Although some laboratory-based studies show an ergogenic effect with beta-alanine supplementation, there is a lack of field-based research in training and competition settings.”
“There was an unclear effect (0.4%; ± 0.8%, mean, ± 90% confidence limits) of beta-alanine on competition performance compared to placebo with no meaningful changes in blood chemistry. While there was a transient improvement on training performance after 4 weeks with beta-alanine (-1.3%; ± 1.0%), there was an unclear effect at ten weeks (-0.2%; ± 1.5%) and no meaningful changes in blood chemistry. Beta-alanine supplementation appears to have minimal effect on swimming performance in non-laboratory controlled real-world training and competition settings” [R].
LeucineTaking Leucine post-workout promotes muscle growth.
However, taking Leucine in your pre-workout has shown to diminish muscular performance via the inhibition of glycogen to glucose conversion within muscle cells and insulin signaling.
On top of that, Leucine can prevent the uptake of Tyrosine into the brain, consequently inhibiting dopamine production, which is the opposite of what we are trying to accomplish pre-workout.
Should You Ever Cycle Off Of Gorilla Mode Nitric?Despite Nitric being stimulant free, I would still advise cycling your use of Gorilla Mode Nitric every once in a while.
In general, I advise cycling your use of any supplement that isn't being used daily to replace a dietary deficiency.
Interfering with balancing mechanisms in the body chronically long-term is almost always going to build up to some unintended negative side effect, and redlining your Nitric Oxide levels and vasodilation on a daily basis for long uninterrupted spans of time will probably be no different.
How often you cycle it is ultimately up to your discretion as there is no tolerance build up with the ingredients in Nitric, and some of them actually have accumulative benefits.
Personally, I use pre-workouts 4 days per week because I workout 4 times per week.
Every month or two I will also take a full week off of everything except for my daily health supplements.
How To Combine Gorilla Mode Nitric With Gorilla Mind RushGorilla Mode Nitric has no stimulants in it, so if you want the most potent combination of performance, energy, focus and drive pre-workout you can combine Nitric with Gorilla Mind Rush.
Dose each product as you would normally dose them on their own, as there is no overlap between the two formulas.
How To Combine Gorilla Mode Nitric With Gorilla ModeGorilla Mode can be combined with Gorilla Mode Nitric to achieve a more middle road level of stimulants but with the maxed out vasodilation and hyper-hydration.
The instance in which mixing the two would make the most sense is if you don't want to use a high dose of Gorilla Mode because the stimulant dosages are higher than you prefer or can tolerate, but still want to max out the benefits of the ingredients included for pump and performance.
For example, if 2 scoops of Gorilla Mode contains too high of a dose of stimulants for you, you could use 1 scoop of Gorilla Mode with 1 scoop of Gorilla Mode Nitric.
Or, a 1/2 scoop of Gorilla Mode with 1.5 scoops of Gorilla Mode Nitric.
Alternatively, if you are using Nitric and want a little bump of stimulants but are too sensitive to the stimulant complex in Gorilla Mind Rush, then you might want to add a bit of Gorilla Mode to your Nitric dose as the blend of stimulants in Mode is a notch less aggressive than the stimulants in Rush.
Mix and match at your own discretion based on your own stimulant tolerance and exactly what you are looking to get out of your pre-workout.
Personally, I love combining Rush and Nitric pre-workout.
Sometimes I will use Mode with Nitric instead though as the Kanna and N-Phenethyl Dimethylamine Citrate hits differently than the stimulants in Rush.
It all depends on what I'm training, how well rested I am, and the effects I am shooting for.
Conclusion - What To Expect From Gorilla Mode NitricIn general, you can expect a massive increase in nitric oxide (NO) levels, vasodilation, intracellular hydration and as significant of a boost in muscle strength and endurance as you can get from a legal non-hormonal pre-workout.
This product is maxed out from all angles.
The traditional Arginine–eNOS–nitric oxide (NO) pathway is completely saturated with an unheard of dose of L-Citrulline, as well as topped out doses of Nitrosigine and Agmatine Sulfate for good measure.
Over a gram of nitrates also ensures that the nitrate–nitrite–nitric oxide (NO) pathway is taken care of.
Intracellular hyper-hydration is best-in-class too with a huge dose of Creatine Monohydrate, Glycerpump and Betaine Anhydrous to volumize the muscle and support performance and pumps.
Inhibiting the enzyme angiotensin converting enzyme (ACE) with a clinical dose of VasoDrive-AP® also checks off another pathway to push the boundaries on supraphysiological levels of vasodilation.
Finally, a high dose of Malic Acid was included for good measure to act as a Krebs cycle intermediary and support greater levels of muscular endurance.
Try Gorilla Mode Nitric for yourself here and let me know what you think.
Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R].
Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors.
These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections.
https://youtu.be/ceqSC6GYks4
Nandrolone And Anadrol Effects On The Immune SystemNandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R].
Testosterone and DHEA had no direct cytokine inducing effect in the same model.
Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells.
Winstrol And Trenbolone Effects On The Immune SystemWinstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R].
Testosterone, Teslac, Anavar And Winstrol Effects On The Immune SystemTo evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R].
Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5).
Significant immunosuppression was observed with all groups.
However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed.
To truly test the effects of endogenous androgens on the immune system a second experiment was then performed.
Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day).
Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13).
In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood.
Levels were either undetectable or very low, reflecting what would be significant HPTA suppression.
Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline.
The Testosterone treated group experienced a 36% suppression of immune function.
Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline.
The results were different in the castrated animals.
Castration, resulted in an increase in immune (DCH) responses.
The mean observed change was 90% greater than intact (pre-castration) baseline.
That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated.
Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline.
Eight day treatment with Anavar combined with physiologic doses of Testosterone produced an even greater suppression, 45% change from baseline.
These observations indicate that immune alterations do occur with anabolic steroids which are immunosuppressive when the steroid nucleus is intact and immunostimulatory with nuclear alterations.
How Steroids Influence Immune FunctionThe hypothesis to explain the immune system responses to steroids is as follows.
Exogenous androgenic anabolic steroids produce two effects on the immune system: (A) a direct early effect on immune function which is suppressive and, (B) an indirect delayed stimulatory effect mediated through the negative feedback on the pituitary.
(B) results in inhibition of gonadal Testosterone through diminished LH release.
A decrease in the synthesis of Testosterone results in low serum Testosterone level and immune stimulation.
Castration, by abolishing the modulation of Testosterone secretion eliminates the effect of (B) but leaves (A) intact.
In summation, the more suppressive a steroid is the more it can indirectly enhance immune function, simply by suppressing the endogenous production of Testosterone and its metabolites.
However, anabolic steroids will also be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner.
So, the only reason anabolic steroids can enhance immunity is by being more tissue selective than Testosterone and by shutting down the HPTA, not by inherently being protective.
They too will be inherently immunosuppressive, just to a lesser degree based on their tissue selectivity and magnitude of impact on endogenous androgen production suppression.
At the end of the day, the data all suggests that the lower your levels of steroids are in the body, the higher level your immune system will function at in parallel.
Are You Increasing Your Risk Of Viral Infection When You Are On Cycle?In summary, the vast majority of studies suggest that steroid use decreases antibody formation, Natural Killer (NK) lymphocyte activity, T and B lymphocyte maturation and stimulation resulting in immunosuppression [R].
Supraphysiological doses of common anabolic steroids have been shown to directly influence the production of certain cytokines, altering immune function.
The results from both animal and human studies suggest that supraphysiological doses of AAS can negatively impact the immune system.
The takeaway from all of this is that with an easily spread virus infecting thousands of people throughout the world right now, it would be prudent to reduce your exogenous AAS use at least down to therapeutic levels to support immune function during this time where having increased vulnerability to viral infection is the most risky.
Regardless if you are young and believe you are invincible based on the mortality rate statistics showing that the elderly are the most at risk of being symptomatic or ending up in critical condition, you may still be increasing your chances of becoming an infected carrier who then transmits the virus to the elderly (including your parents or grandparents) as a result of self-induced immunosuppression.
Arnold Schwarzenegger's steroid cycle from the golden era of bodybuilding is a topic that is often heavily debated.
There's a lot of speculation around what kind of drug use the golden era bodybuilders deployed to get the physiques that are so sought after nowadays.
While Arnold himself never detailed exactly what he took, we have a handful of credible sources of information that all seem to overlap in their descriptions of his steroid use.
Despite this information being very accessible, it often goes overlooked because it is buried in the nooks and crannies of the internet.
There is such an overwhelming amount of content on the internet now that this information has become increasingly more difficult to find over the years.
While Arnold likely experimented a bit here and there, this article will detail what he built his physique on, and the staple anabolics he very likely used throughout his Mr. Olympia reign.
https://youtu.be/Ap9I1ReF5KY
Arnold Schwarzenegger Briefly Touches On His First Steroid CycleIn Arnold Schwarzenegger's autobiography "Total Recall - My Unbelievably True Life Story" he gives some insight into what his first steroid cycle consisted of, and when he started it.
The first thing of note is that he discovered steroid use before the 1967 Mr. Universe competition while researching about the training methods of the East Germans and the Soviets.
There were rumors that they were using performance enhancing drugs to get superior results from their weightlifters, shot-putters, and swimmers and he soon found out that steroids were the drugs that they were using.
Arnold goes on to touch on how he went to a doctor to ask for a prescription of anabolic steroids.
He simply asked:
Can you let me try it?
The doctor agreed, and he was then prescribed an injection every two weeks and pills to take in between.
Keep in mind, this was Arnold's first steroid cycle ever.
His dosages may have titrated up in subsequent cycles, and he probably experimented with different anabolics at some point at least once or twice.
The more muscle you gain, the higher your requirements will become for increasingly high amounts of calories, training volume, and drug use to support additional hypertrophy above and beyond what you have already achieved.
While Arnold didn't state exactly what he was prescribed, we get some useful insight into the administration practice of each compound (oral and injectable) and what type of drugs would probably fall into these two categories at that time when considering all of the other information from other interviews we have compiled over the years.
At this point, we know he was using one injectable compound and one oral compound.
Arnold Schwarzenegger's Interview About Dianabol UseIn another interview Arnold more or less implies that he used 3 Dianabol per day.
It is well-known in the community that Arnold was big on using Dianabol back in the day.
https://youtu.be/szGZ0bMxcTg?t=7
Obviously he's not actually straight up saying "this was what my cycle was", but we can put two and two together based on his prescription for pills and an injection from a doctor, Arnold talking about Dianabol himself, and the widespread information that's passed through the grapevine reinforcing his Dianabol use.
It all culminates to paint a pretty convincing picture that Dianabol was the oral steroid in question that Arnold used.
What the injectable compound was is mainly what is debated about.
After doing some digging, I uncovered some pretty convincing information suggesting that the injectable compound was Primobolan.
Steve Davis Outlines Golden Era Steroid CyclesIn 2012, Ric Drasin interviewed Steve Davis to discuss steroid cycles from the golden era.
Both men trained at Gold's Gym with Arnold in the 70's and had personal insight into what golden era stacks consisted of, as they literally took the same stacks themselves.
After prompting the topic of what golden era bodybuilders were using, Steve goes on to touch on what most guys were using:
Steve: You know, in my era, it was 3 Dianabol a day and a shot a week.
Ric: That's exactly right.
Steve: And we heard that certain Austrians were taking 4 Dianabol a day and a shot a week.
Ric: Yeah.
https://youtu.be/31-kQbjtxDc?t=453
I'm sure both Steve and Ric actually had this conversation with Arnold at some point to confirm this, as they trained with him and bodybuilders were supposedly pretty open about their use back then.
The standard protocol going around then was 3 Dianabol a day, and 1 shot of Primobolan per week.
While some of the protocols definitely differed from person to person (e.g. Robby Robinson and Danny Padilla using Deca-only cycles), for the most part it seems like the majority of guys that trained with Arnold in Gold's Gym in the 70's were doing the same thing.
Now, the question is are they underplaying their use to not undervalue their training intensity and diet adherence?
Perhaps.
It is very common for "open" individuals to talk about their steroid use, but basically just cut what their dosages are in half when speaking about what they took.
Ric Drasin Details Golden Era Steroid CyclesIn 2018 Ric Drasin circles back to the topic of golden era steroid cycles and outlines more specifics about what steroids the top bodybuilders from Gold's Gym were using in the 70's.
Now I was there at that time, so I know exactly what everybody took.
Without using names of people because I don't want to implicate anybody, but starting with the top bodybuilders, and some that you know, it wasn't that much
use of steroids the way we think of today.
Basically, it was Dianabol, Primobolan, Testosterone, Deca, Winstrol, and Anavar.
Those are the main ones.
There wasn't anything outside of that.
Growth Hormone wasn't really known about then, so nobody really used it.
I mean, maybe it was in some circles, but we sure didn't hear about it.
Mostly tablets.
The injectables were the ones I mentioned.
The Winstrol, the Dianabol, and the Anavar were strictly tablets, there was no injectable at all of that sort.
Dianabol was made by CIBA (C-I-B-A).
It was a little blue pill.
Came in 100 a bottle.
If you bought it at the pharmacy, it was a prescription, it was $8 a bottle.
Deca was $1.50 a vial, that's it.
Testosterone.
Let's say, 10 CCs of an enanthate was 10 bucks.
Anavar, around the same price and down the line, nothing was really expensive.
Now, you have to realize back in '69 and the 70's, steroids were not illegal.
They were never looked upon as being illegal.
There was a doctor's prescription.
You could get it pretty easily if you needed it, and then you had it.
There were those doctors that were affiliated with Gold's Gym back in those days that would just hand it to you.
One was a pediatrician who was well-known.
The other one was a medical doctor, who was well-known.
If you needed something, you got it.
Now, from the top of the line bodybuilders, the ones that were competing in the Olympia back then, from Gold's, their main routine was taking Primobolan, Winstrol, and Deca.
Forgot to mention Deca.
And not in any great usage.
It was like a "CC" of each, maybe once to twice a week.
That was it.
People seem to think that some of these guys were taking like "10 CCs" a day, every day.
I never saw it happen.
No way in hell that ever happened.
Dianabol, no more than three to four pills a day, at most.
Anavar was weak, so six to eight pills a day.
Winstrol was four pills a day.
Now, I started on Dianabol back in the, maybe, late 60's.
I had heard about Bill Pearl taking it.
I got it from a pharmacy, CIBA, and I started doing two pills a day.
By 10 days in, I had grown so much, it was ridiculous.
This is when everything was real.
I really grew from that Dbol and they quit making it way back.
Maybe, the mid 80's.
CIBA just went out of business and that was it.
It became illegal.
They said on the bottles themselves that these drugs would not enhance athletic performance.
They had to label that on there.
And, then they took it off of there.
Primobolan coming from Germany, or Austria I might say, was probably one of the best things I ever tried.
It was given to me by "one of our big bodybuilders" at the time.
I had great results off that.
I got so huge in two weeks, I could hardly fit into my Volkswagen.
And I'm not kidding.
That's how big I got just off that and the Dbol.
I never took great amounts.
1 shot a week, 3 Dbol a day, maybe 2 Dbol a day.
So, when you asked what these guys took, and how much did they take, and "did they take a lot?"
No, it wasn't a lot at all.
And I always felt that "less was more."
You didn't need a whole lot to get big.
If you took too much, it didn't really work that well.
It wasn't any better than taking less.
It was available pretty easy.
Like I said, it wasn't illegal.
Everybody had it.
And that's how it was.
But most of the results in training came from heavy-lifting old school style, and a lot of protein.
https://youtu.be/j7BafGZt2RY?t=60
One of the "big bodybuilders" gave Ric Primobolan for the first time, and he was following the classic dosing protocol we've seen mentioned time and time again now.
A few Dbol per day, and a shot of Primo per week.
Arnold Schwarzenegger’s Dosage Titration ProtocolA credible guru in the industry details what is purported to be Arnold's dosage titration protocol at the 37:18 mark in the following video:
https://youtu.be/GVV_dCPKhho?t=2238
Arnold took Dianabol and Primobolan, essentially nothing else.
An escalating dose, kind of culminating in about 100 milligrams of Dianabol a day and about 1000 milligrams Primobolan a week, a.k.a. about two total grams of drug and that was it.
No aromatase inhibitor, no Tamoxifen, no Insulin or Growth Hormone, just two grams of high-quality anabolic.
By the way, you didn't hear mentioned any Testosterone.
Testosterone really didn't come onto the scene 'til the late 70's, early 80s'.
I have no idea how factual that purported titration schedule was, but it still reinforces the likelihood that Arnold's steroids of choice were Dbol and Primobolan.
Frank Zane's Semi-Cryptic Poem About Golden Era Steroid CyclesThe nail in the coffin in my opinion is Frank Zane's poem.
In Frank Zane's "Mind, Body, Spirit" training diary, one Reddit user actually found a poem that essentially breaks down in code what the top bodybuilders took in the golden era.
Diana Bowl and Louie.
Prima bowl on
TV, both of whom
worked as a team.
Known for miles around
as the best bowlers in town,
Primo drove 100 miles a week
combining 15 milly Gramola bars daily from Diana
not worried about getting fat, you cannot
not on that in those days.
But that was then, this is now
a growing cast of actors shove, share center stage
all playing the same part at the same time
I awoke amazed, wondering how
this ridiculous play isn't dying by now.
Obviously, anyone can see plain as day he's trying to allude to certain things in code here to outline what drugs guys were taking back then, as well as what appears to be his perspective on modern day bodybuilding as a whole compared to the golden era.
The first thing, "Diana Bowl."
Obviously, that's Dianabol.
"Prima bowl on."
Primobolan.
"Primo drove 100 miles a week."
100 milligrams per week of Primobolan, which reinforces the one shot a week of Primobolan that Arnold supposedly got.
"Combining 15 milly Gramola bars daily from Diana"
15 milligrams per day of Dianabol (Dbol) combined with the weekly shot of Primo.
After the part where he talks about 100 milligrams of Primo per week and the 15 milligrams of Dianabol per day he says:
"But that was then, this is now.
A growing cast of actors shove, share center stage.
All playing the same part at the same time.
I awoke amazed, wondering how this ridiculous play isn't dying by now."
I assume this part refers to his perspective of modern day bodybuilding compared to the golden era and how this generation abuses high dosages of multiple drugs, and how much of a travesty he believes bodybuilding has become.
I believe it more or less stands for everything wrong with modern-day bodybuilding.
The excessive mass chasing, the insane dosages of drugs, and him being amazed the "play isn't dying by now" perhaps alluding to the fact that bodybuilding has continued to remain popular despite an increasing amount of young bodybuilders dropping dead from drug abuse.
There's a lot to take in from that poem.
Dianabol (Dbol) And Primobolan Dosages
Ric Drasin and Frank Zane both trained with Arnold and seem to be credible sources of information.
Frank Zane is a Mr. Olympia winner himself and would know better than anyone what others from Gold's Gym were using.
The cumulative evidence strongly suggests that Arnold was at minimum using a shot of Primobolan per week and 3-4 Dianabol per day.
It is entirely possible that those dosages titrated up over the years, but in general we at least know that those were likely the compounds he used to build his physique.
CIBA Dianabol was prescribed in 2.5 and 5 milligram oral tablets.
All forms of Bayer Primobolan Depot were packaged in one milliliter glass ampules and contained 100 milligrams of Metenolone Enanthate.
Arnold Schwarzenegger’s Steroid CycleBased on the information provided, we can assume that Arnold Schwarzenegger’s steroid cycle consisted of 15-20 milligrams of Dianabol per day and 100 milligrams of Primobolan per week.
Those are very conservative dosages by today's standards, and this was reinforced by every one in the golden era who has spoke out about the steroid use in that tight knit circle of bodybuilders Arnold hung out with.
Obviously they could be wrong or lying, but I think their stories line up too well with each other for it to not be at least somewhat true.
Hopefully that lays some myths to rest and sheds light on what the golden era bodybuilders were actually doing to achieve the physiques that everyone strives for nowadays.
Nowadays, guys abuse excessive amounts of drugs in hopes of achieving golden era physiques, when the golden era guys were actually using a fraction of what teenage kids are cycling on nowadays.
Granted, there may be a huge disparity in product quality between the pharmaceutical grade products available in the golden era compared to the UGL stuff most guys are using now.
However, I do not believe that to be the case, with the exception of product purity and complete dosage accuracy.
Most top UGL's are pretty on point and aren't far off of pharmaceutical quality, so to me that point usually just comes across as an excuse that guys use to justify using massive dosages, or for their lackluster results.
The golden era steroid dosages were far more reasonable than most would otherwise believe had they not seen this stuff, or heard it straight from the horse's mouth.
I don't think you will find a more credible resource than Arnold, Frank, Ric, and Steve themselves who have opened up about the standard dosages used in that era, with their statements all lining up with eachother.
Gorilla Mind Smooth is the most potent and comprehensive stimulant-free Nootropic formula on the market.
If you don't already know what Nootropics are, they are a category of compounds that can improve cognitive function.
This can extend into many different specific benefits, but the main draw of Nootropics is their impact on productivity, concentration, creativity and information retention.
Gorilla Mind Smooth is our stimulant-free version of Gorilla Mind that provides a smoother, much less extreme level of energy, but still maximizes mental clarity, memory, creativity and focus.
Regardless if you're currently using stimulant-based products (coffee, energy drinks, pre-workouts, etc.), cycling off of stimulants, or just never use stimulants, Gorilla Mind Smooth is the most potent Nootropic formula you can add into your life to enhance cognitive function.
https://youtu.be/Hcj8CinGG6s
ReviewsThese are some of the reviews we've received from customers using Gorilla Mind Smooth:
Gorilla Mind Smooth Supplement FactsPer Full Daily Dose:
The original Gorilla Mind Smooth formula had PEA, Hordenine and Teacrine in it.
Originally, I was trying to chase a stimulant-free energy boost in Smooth, which is why I had those ingredients in it.
However, over the past year I've started to really lean towards reformulating Smooth to create an entirely Nootropic comprised formula that is 100% geared towards maxing out cognitive function, rather than chase a relatively weak level of energy that we already destroy with Gorilla Mind Rush.
Anyone buying Gorilla Mind that is using it for the laser focus and massive boost in energy and productivity is buying RUSH anyways, not SMOOTH.
Instead of wasting precious capsule space with things that achieve a subpar level of energy, I decided that space would be far better utilized with other Nootropics.
This is what led to me creating the current Gorilla Mind Smooth formula, which now has 1000 mg of Lion's Mane mushroom and 500 mg of Kanna in it.
These compounds are far more conducive to enhancing the SMOOTH formula by supporting actual brain health, creativity, mental clarity and memory formation.
If you want ridiculous amounts of energy and drive, get RUSH.
For those who want a true stimulant-free Nootropic formula, SMOOTH is even better now and I highly recommend you give it a try.
Gorilla Mind Smooth Vs. Other Nootropics On The MarketThis is the most maxed out stim-free Nootropic formula on the market.
The full daily dose is 6 capsules.
Even a half dose (3 capsules) is still far more potent than the majority of other Nootropic formulas out there at their max dosages.
I formulated Gorilla Mind Smooth the exact same way I formulate any other product.
I put in exactly what I would buy myself if I were shopping for each Nootropic separately.
If you thought the pre-workout market was bad for underdosed products, your jaw will drop when you see some of the top selling Nootropic formulas.
This industry is even worse because it is so niche and new.
Preying on unsuspecting customers with garbage formulas sprinkled with vitamins and completely useless dosages of Nootropics is even more common in this industry.
Because Nootropics are relatively new and uncharted waters for many, the prices get pretty aggressive on these watered down formulas as well that promise the world, and deliver nothing more than placebo.
What's baffling to me is how many people eat up the marketing and blindly buy products priced at $60, $70, even $100 that probably cost $4-5 max to make.
When the cost of bottles, lids, and labels costs more than the Nootropics in your formula, there's a f*cking problem.
Fortunately, my audience is comprised of intelligent individuals who actually know how to spot value.
It would be so easy to make a formula with a couple hundred milligrams of cheap choline that doesn't even cross the blood brain barrier, 100-200 mg of Bacopa Monnieri, throw a bit of caffeine in there for a kick, put some exotic sounding ayurvedic herbs in there, maybe sprinkle a couple low dosed Adaptogens in there, add a useless pinch of vitamins to make my label look more impressive and confusing, and then slap a label on it like every other company and then aggressively smash people with ads and market a high priced subscription model to the masses, or put it up on Amazon to compete with all the other loss leader cheap and ineffective Nootropics on there.
The fact that the hypothetical piece of sh*t formula I just made up as an example of what not to do is actually still better than most of the Nootropic formulas on the market just goes to show how much some companies are deceiving their customers.
If the majority of a company's budget goes into ads and sponsorships instead of product formulation, or they have a high ranking product on amazon, you can almost guarantee without even looking at the product that it sucks.
Unlike what most companies will lead you to believe, there is no Nootropic formula that will lock you in like Bradley Cooper from Limitless (great movie by the way).
https://youtu.be/4TLppsfzQH8
Just like our other products, it is me making the formula, and I put in what I would want to use as a customer.
I used to spend time every day in University measuring out all my different Nootropics that were in my "stack", and toss and washing random powders.
Obviously it makes things much easier to just have it in ready to go capsules that are actually dosed properly.
With my products, everything is turnkey.
How To Dose Gorilla Mind SmoothTake 3-6 capsules in the morning, or spread throughout the day.
Start with 3 capsules to evaluate your tolerance.
While Gorilla Mind Rush requires more of a tolerance assessment and slow dosage titration over time due to the heavy hitting stimulants, you will more than likely be fine jumping head first into Gorilla Mind Smooth and tapering up to the maximum recommended dose relatively quickly.
Gorilla Mind Smooth Vs. Gorilla Mind RushWhile the foundation of Nootropics in both Gorilla Mind products are mostly the same, there are some key differences between the two formulas.
The main difference is that RUSH has a handful of potent stimulants that completely change how the product feels.
RUSH is best stimulant-based Nootropic formula on the market for really waking you up and giving you tunnel vision focus and productivity.
The strong backbone of Nootropics in RUSH are the portion that can actually enhance information recall, creativity, etc.
But, the stimulants in RUSH are the driving force of the product, and can really be a game changer in productivity.
SMOOTH on the other hand is stimulant-free and has the same Nootropics as RUSH, but also has 1000 mg of Lion's Mane mushroom and 500 mg of Kanna.
Lion's Mane is amazing for supporting cognitive health, memory formation and mental clarity, while Kanna is a potent mood booster and can also support improved focus and energy levels.
Gorilla Mind Smooth is significantly toned down in the energy department, so if you have too high of a sensitivity to stimulants or simply want a smoother level of focus, this would be more ideal for you.
How To Combine Gorilla Mind Rush And Gorilla Mind SmoothIf you don’t want to pick between either having the giant burst of energy and laser focus that RUSH provides, or the cognitive enhancing benefits of the Lion's Mane and Kanna in SMOOTH, you can combine the products.
By taking 6 capsules of either, you will be getting a top end dose of Nootropics.
Even with 3 capsules of either product you will still get an effective dose of Nootropics, and with RUSH, many won't even be able to exceed 3 capsules because the stimulant blend is extremely strong.
If you are not a stim junkie who needs 6 capsules of RUSH I would recommend getting both so you can strategically tweak how much energy you want to get from the Rush to not over-stimulate yourself, but also reach the maxed out mental benefit you would get out of the Nootropics in each respective version of the product.
Rotating Gorilla Mind Smooth and Gorilla Mind RushUse Gorilla Mind Rush on days that require the most focus, productivity and energy.
By rotating RUSH and SMOOTH, you can keep yourself sensitive to the stimulants in Gorilla Mind Rush, and reap the maximum benefit from each product during each use.
Do You Need To Cycle Off Of Gorilla Mind Smooth?While SMOOTH will not cause tolerance build up like RUSH, I would still advise cycling off of everything for a week every month or so.
Alternatively, allocate a couple days each week to days you do not take anything, including RUSH.
Gorilla Mind Smooth Ingredients Breakdown L-Tyrosine - 1000 mgL-Tyrosine is an amazing cognitive enhancing amino acid that acts by balancing neurotransmitter levels in the brain.
Its primary role is as the direct precursor to thyroxine and to the neurotransmitters dopamine, epinephrine, and norepinephrine.
L-Tyrosine shines in its ability to improve mental sharpness, focus, energy levels, and cause mood elevation [R, R].
L-Tyrosine Vs N-Acetyl L-TyrosineL-Tyrosine is the most bioavailable form of Tyrosine.
In short, N-Acetyl L-Tyrosine is very inefficiently converted by the body to Tyrosine [R].
Even IV’ing N-Acetyl L-Tyrosine can’t elevate plasma Tyrosine levels to a significant degree, let alone via oral ingestion.
Claims of increased water solubility and bioavailability are all marketing hype and were disproved easily by showing just how poorly N-Acetyl L-Tyrosine is at converting to Tyrosine in the body.
The graph above depicts arterial concentrations of N-Acetyl-L-Tyrosine (NAT) and Tyrosine (Tyr) during intravenous infusion of N-Acetyl-L-Tyrosine.
As you can see, Tyrosine levels barely even budge.
This is the same kind of tactic used to try and market new and “improved” forms of creatine that at the end of the day do not yield any additional benefit, and just feature an inflated price tag.
In our first batch of Gorilla Mind, we actually had N-Acetyl-L-Tyrosine in the formulas based on these claims of improved water solubility and bioavailability by our manufacturer at the time.
After delving into the data further, I realized the massive difference in bioavailability and swapped out the N-Acetyl-L-Tyrosine for straight L-Tyrosine, found a better manufacturing facility, and all batches of Gorilla Mind products since then have featured L-Tyrosine instead.
Organic Lion's Mane Mushroom (Hericium Erinaceus) (standardized to 25% β-glucans) - 1000 mgLion’s Mane is a Nootropic and cognitive-enhancing mushroom that has been used for thousands of years by Buddhist Monks who believed that it enhanced brain power and improved their focus.
The main reason it is so promising as a Nootropic is the effect it has shown to have on the synthesis of nerve growth factor (NGF) and neurogenesis.
By enhancing neurogenesis and potentially even attenuating the negative effects of cognitive decline, Lion’s Mane may significantly improve mental acuity, information retention, and decrease mental fatigue.
Most products on the market contain 250 - 500 mg of Lion’s Mane.
We have a full gram (1000 mg) in Gorilla Mind Smooth to ensure you are actually getting an efficacious dose of Lion’s Mane in when you use it.
Effect On Cognitive FunctionA double-blind, placebo-controlled trial was conducted on 50-80 year old adults with mild cognitive impairment to evaluate the efficacy of Lion's Mane as a cognitive aid.
The Lion's Mane treated group showed significantly increased scores on the cognitive function scale compared with the placebo group [R].
Enhanced Nerve Growth Factor (NGF) SynthesisResults from animal studies support that Lion's Mane can enhance the synthesis of Nerve Growth Factor (NGF) [R, R].
NGF is required by neurons in order to survive and appears to play a major role in cognitive function.
When NGF decreases in the brain, memory formation and information recall becomes greatly impaired.
By maintaining optimal levels of NGF one may be able to support brain plasticity for improved information retention, memorization, as well as general cognitive health.
Effect On Beta Amyloid Levels And Cognitive DeclineIn a rodent model, Lion's Mane was shown to attenuate the negative cognitive effects of beta amyloid in the brain (what is believed to be the main cause of Alzheimer's) [R].
It was also shown to ameliorate Alzheimer’s disease-related pathologies in several other rodent models of Alzheimer’s disease [R, R].
Mood Elevation And Stress ReductionLion’s Mane also contains erinacine and other bioactive compounds that may increase dopamine production and improve state of well-being.
One study showed that Lion's Mane supplementation reduced depression and anxiety after 4 weeks of use [R].
DMAE (Dimethylaminoethanol) - 750 mgDMAE's mechanism of action isn't fully understood, but it appears to work primarily by stimulating cholinergic receptors and has shown to improve cognitive function, energy levels, focus, and act as a neuroprotectant [R].
DMAE users consistently report improved memory, attention to detail, focus and mental clarity.
DMAE Vs. Ritalin StudyOne double-blind, placebo-controlled study conducted on 74 children with learning problems compared the efficacy of DMAE to Ritalin for treating ADHD [R].
The children were either given 40 mg of Ritalin, 500 mg of DMAE, or a placebo every day for 3 months.
Behavior rating forms, reaction time, and an array of other psychometric tests were given before and after treatment.
DMAE showed improvements in these metrics of approximately the same magnitude as Ritalin.
No major side effects were noted with either treatment with exception of 6 of the children on Ritalin noting appetite suppression.
Alpha GPC 50% (L-alpha-glycerylphosphorylcholine) - 600 mgAlpha-glycerylphosphorylcholine (Alpha-GPC) is the highest quality and most bioavailable form of Choline.
Taking massive dosages of straight Choline has shown to have no cognitive effect in humans [R].
Alpha-GPC on the other hand has shown to cross the blood brain barrier and provide the brain with a rapidly absorbed form of choline.
This then supports the synthesis and release of acetylcholine.
The surge of quickly absorbed choline in conjunction with the release of acetylcholine helps support an array of cognitive functions including but not limited to memory, HGH production, physical performance, concentration, focus, and information absorption/recall [R, R, R].
Alpha-GPC has also shown to significantly increase strength and may be an effective ergogenic aid [R].
How Much Choline Do You Need Per Day?The Adequate Intake (AI), as established by the Food and Nutrition Board of the National Institute of Medicine, for adults is 550 mg per day for men and 425 mg per day for women.
We all know how brutally underestimated some of the AI's have proved to be in the past couple decades, and there is evidence suggesting that the AI for Choline is also far too low.
One study showed that 2200 mg per day of Choline protected against the DNA damage that otherwise occurred in people consuming only 550 mg [R].
There are not enough studies on Choline, and it is a severely lacking area of research considering how important it is for brain health.
I would shoot for at least 900-1200 mg of Choline per day.
A big chunk of that can be achieved through regular liver and egg yolk consumption, but supplementation will help you hit that number with much greater ease.
I eat 1 ounce of beef liver, 4 large eggs, and supplement with 600 mg of Alpha-GPC every day via Gorilla Mind.
I also take extra precautions to support methylation, which I will delve into later in the methylation subsection.
Alpha-GPC's Effect On Alzheimer's Dementia
In a double-blind, randomized, placebo-controlled trial, patients with Alzheimer's dementia were treated with Alpha-GPC (400-mg capsules) or placebo capsules, 3 times daily, for 180 days [R].
In the Alpha-GPC group, assessed parameters consistently improved after 90 and 180 days versus baseline, whereas in the placebo group those same parameters remained unchanged or worsened.
The results suggest that Alpha-GPC is a promising intervention for attenuating the cognitive decline that occurs from neurodegenerative disease.
Alpha-GPC's Effect On Methylation And Health StatusThe MTHFR gene codes for an enzyme called methylenetetrahydrofolate reductase, or MTHFR.
This enzyme is needed for the production of DNA and supporting methylation pathways that are essential for all bodily functions.
Genetic variations in this gene results in reduced activity of the enzyme and has been associated with cardiovascular disease, neurological defects, some forms of cancer, and a myriad of other diseases and disorders [R, R].
Personally, I am homozygous for C677T of MTHFR, which results in a 80-90% decrease in my efficiency in processing folic acid.
The direct reflection of that in blood biomarkers can be high homocysteine and low B12 and folate levels.
I determined this via a simple 23andMe genetics test.
Normally your body creates methyl groups by recycling Homocysteine to Methionine, as well as by converting Choline to Betaine.
When nutrient intake needs are sufficiently met, the body depends on these two mechanisms equally.
However, if you are deprived of methyl groups or have poor MTHFR activity because of a polymorphism, you can change that and start to create a disproportional ratio of dependency on the Choline to Betaine pathway.
If you can't create enough Methylfolate, your body will ramp up the use of Betaine and Choline for methyl groups.
By ramping up Choline to Betaine conversion to support methylation, your body can become depleted of the Choline it needs to create Acetylcholine.
Downstream, the depletion of Choline can eventually lead to impaired cognitive function, DNA damage, and can be deleterious to overall health.
The prevalence of MTHFR polymorphisms and micronutrient deficient diets is so common nowadays that almost everyone could benefit from Alpha-GPC supplementation to maintain higher levels of Choline.
I take 600 mg of Alpha-GPC every day on top of the Betaine and Creatine I get from Gorilla Mode (or Gorilla Mode Nitric when I am not taking stimulants) to support methylation, improve my health, and optimize my performance.
Alpha-GPC Vs. CDP CholineAlpha-GPC raises choline blood levels much more than CDP-Choline.
While there is some speculation around the fringe benefits that may come with the Cytidine component of CDP-Choline, in general, the main reason we would use either Alpha-GPC or CDP-Choline is to supplement our diet and raise our Choline levels.
Alpha-GPC accomplishes this better than CDP-Choline.
Our Alpha-GPC is 50% Choline by weight, whereas CDP-Choline is only about 18% Choline by weight.
That means that you would need to use almost three times as much CDP-Choline to get the same amount of Choline as Alpha-GPC.
Are any of the companies out there with CDP-Choline in their formulas putting 1600-1700 mg of CDP-Choline per daily dose in their products?
Not even close.
Many companies still use Citicoline (CDP Choline) in their Nootropic formulas, despite the fact that Alpha-GPC has shown time and time again to be more effective both anecdotally, as well as clinically [R].
From what I've seen, the most reputable anti-aging "biohackers" in the industry also prefer Alpha-GPC over CDP-Choline.
I have personally tried CDP-Choline and never really noticed any enhancing effect like I seemed to with Alpha GPC.
- Rhonda Patrick (Ph.D in biomedical science/expert on nutritional health, brain & aging)
Kanna (Sceletium tortuosum) - 500 mgKanna supplementation has been found to effectively lower stress, elevate mood and increase focus.
Personally, I notice a huge boost in my mood and I lock in a little bit more on whatever I am trying to concentrate on when I supplement with Kanna.
Kanna was a huge success in our pre-workout formula because it also complements stimulants very well, which you have probably found out first hand if you have tried Gorilla Mode.
Kanna works mainly via increasing the amount of serotonin available in the brain, and is typically utilized for its anti-anxiety and mood elevating effects [R].
This is an ingredient you will really feel, and can be especially useful for those days you need something effective that isn’t stimulant based.
Anecdotally, a dose between 200-500 mg of Kanna has shown to be ideal for oral ingestion.
Higher dosages between 1-2 grams have been associated with unwanted side effects like dizziness.
Kanna has no addictive properties, and it is not hallucinogenic [R, R].
One thing to keep in mind with Kanna use is that it has a high affinity for the serotonin transporter.
Therefore, it is plausible that Kanna can interfere with SSRI pharmaceuticals.
Bacopa Monnieri (standardized to 45% Bacosides) - 400 mgBacopa Monnieri is typically used as a memory enhancing Nootropic.
There is a growing body of evidence suggesting that Bacopa Monnieri can protect neurons in the brain from accumulative damage, reduce β-amyloid levels in the brain, and improve cognitive performance by modulating neurotransmitters [R].
The efficacy of Bacopa Monnieri has been reinforced in six high-quality randomized, double-blind, placebo-controlled human trials.
The results suggest that Bacopa Monnieri not only has the potential to attenuate neurodegenerative disease progression, but it may also be a potent memory enhancing agent in otherwise healthy individuals.
Improved Verbal Recall - Bacopa Monnieri Vs. Modafinil StudyIn a meta-analysis, long-term Bacopa Monnieri supplementation produced more consistent and noticeable positive effects than Modafinil [R].
Primarily, Bacopa Monnieri was shown to be very effective at improving verbal recall.
This suggests that Bacopa Monnieri would be especially useful for memorizing long speeches, business presentations, songs, scripts, etc.
Apparently Bacopa Monnieri was used by ancient Vedic scholars to memorize lengthy hymns and scriptures, which would reinforce the clinical findings.
Improved Information Retention And Memory ConsolidationA randomized double-blind placebo-controlled study conducted on 46 healthy adults assessed the efficacy of supplementing 300 mg per day of Bacopa Monnieri for 12 weeks [R].
23 subjects received Bacopa Monnieri, and 23 subjects received placebo.
A battery of well-validated neuropsychological tests were used to assess Bacopa's efficacy as a Nootropic.
The Bacopa Monnieri treated group had significantly improved speed of visual information processing, learning rate, memory consolidation, and state anxiety compared to placebo, with maximal effects evident after 12 weeks.
In another study conducted on 76 healthy adults aged 40-65, Bacopa Monnieri showed significant improvements in information retention [R].
Another study conducted on 81 elderly Australians found that a Bacopa Monnieri extract produced significant improvements in verbal learning, memory acquisition and delayed recall [R].
L-Theanine - 200 mgL-Theanine is most commonly used for its calming and relaxing effects.
I find that it also promotes a high level of mental clarity as well.
L-Theanine primarily works by targeting the neurotransmitters GABA, Serotonin, Dopamine, Epinephrine and Norepinephrine.
These neurotransmitters are responsible for feelings of attention, stress, arousal, relaxation and pleasure.
By mitigating the over-activity of excitable neurotransmitters and enhancing the calming neurotransmitters, L-Theanine seems to help calm down the brain, reduce stress, and curb anxiety.
This is why L-Theanine complements stimulants like caffeine so tremendously too, as it takes the edge off of stimulants that can cause jitters and over-stimulation.
Stacking Caffeine With L-Theanine To Help You Get To Sleep And Smooth Out The JittersIf you get jitters even with low doses of caffeine, the L-Theanine in Gorilla Mind Smooth will really help curb that.
The caffeine + L-Theanine stack is one of the most basic and effective Nootropic stacks to date.
This is one of the main reasons why Gorilla Mind Rush won't send you off the rails despite having a very potent combination of stimulants in it (it also has a big dose of L-Theanine in it).
If you love your coffee, green tea, or energy drinks and don't want the aggressive stimulant blend in Gorilla Mind Rush, Gorilla Mind Smooth will stack with your caffeinated drink of choice exceptionally well.
One notable rodent model even showed that L-Theanine can partially counteract caffeine-induced sleep disturbances [R].
Improved Memory And AttentionIn a randomized, double-blind, placebo-controlled study conducted on 91 people with minor brain damage, a combination of L-Theanine and green tea extract improved memory, attention span, and alertness during a memory test [R].
Improved Verbal Fluency And Executive FunctionIn another randomized controlled trial, 30 healthy adults were given 200 mg of L-Theanine per day, or placebo.
Verbal fluency and executive function scores improved after L-Theanine administration [R].
Stress levels also went down, and sleep quality also increased after L-Theanine administration.
Improved Reaction TimeIn another study conducted on 18 healthy University student volunteers, 200 mg of L-Theanine improved attention performance and reaction time response [R].
NeuroprotectionIn a study conducted on elderly volunteers with normal or minor cognitive dysfunction, volunteers who ingested powdered green tea containing 47.5 mg of theanine per day showed significantly lower decline in cognitive function compared with that of the placebo group [R].
BioPerine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) - 10 mgBioperine is a trademarked form of black pepper extract standardized to 95% Piperine.
Black pepper extract is a very effective CYP3A4 and P-glycoprotein inhibitor [R].
These enzymes break down molecules like epinephrine and norepinephrine in the body.
By prolonging the breakdown of the cognitive enhancing ingredients in this formula, Bioperine extends how long they work for, and can also significantly increase their bioavailability.
Huperzine A - 400 mcgHuperzine A works by inhibiting acetylcholinesterase in the brain, which is an enzyme that breaks down the neurotransmitter acetylcholine.
Acetylcholine is not only a major regulator of cognitive performance, but it is also an important neurotransmitter needed for optimal muscular contractions during exercise.
Huperzine A has shown to promote neurogenesis (the birth of new neurons in the brain) and act as a neuroprotective agent for existing neurons in the brain.
In turn, Huperzine A has shown to enhance memory, focus and overall cognitive function [R, R].
Huperzine A is one of the most potent Nootropics that you can really “feel” and it complements the other Nootropics in this formula perfectly.
Other Notable Compounds I Didn’t Include In The Formula And Why Noopept, Racetams, Other Synthetic Nootropics And ProdrugsAlthough they are effective Nootropics, Noopept, Racetams (class of drugs all named with the suffix "racetam"), prodrugs like Adrafinil, and other synthetic compounds that cannot be found in nature or in the food supply are not DSHEA compliant and cannot be legally sold as dietary supplements, so we did not include any.
If this wasn't the case, I probably would have included 30 mg of Noopept in the formula.
I also like Phenylpiracetam.
VitaminsVitamins are often included in Nootropic formulas to make a supplement facts panel look more impressive.
If a company is willing to sacrifice room in their capsules to inflate their ingredient profile with stuff you very likely already get from diet or a multivitamin, that is a major red flag.
More often than not, the dosages included are next to useless and are just there to make a product look more comprehensive.
The main issue with this is that you only have so much room in a capsule.
Most Nootropic products use a "00" capsule size in their bottles.
Each "00" sized capsule can fit about 735 mg in it.
That is precious space, and including a useful amount of vitamins in a product can easily take up several capsules of space.
If a company is wasting space with vitamins and only has a serving size of around 6 capsules, they are probably just trying to hide the fact that the actual Nootropics portion of their formula is watered down garbage.
Conclusion - What To Expect From Gorilla Mind SmoothIn general, you can expect clear headed mental clarity, as well as improved information retention, creativity, productivity and concentration.
Gorilla Mind Smooth is not designed to jack your brain into high gear, as that is a stimulant driven mechanism.
Rather, it is purely meant to enhance cognitive function and overall mental performance.
Try Gorilla Mind Smooth for yourself here.
Of the minority of men taking steroids who actually get blood tests, 99% of them get inaccurate assays.
Most doctors don't realize the importance of high sensitivity testing when it comes to men in general, and even more so in steroid users.
The difference between high sensitivity testing and what you have probably been getting in the past can be the entire reference range, or in some cases, it may even be detecting metabolites or analogs of other hormones.
This is not limited to just testosterone either.
Measuring Estradiol via Roche ECLIA (Electrochemiluminescence Immunoassay) instead of liquid chromatography with tandem mass spectrometry (LC/MS-MS) has similar limitations, as do other hormone tests with insufficient analytical sensitivity.
https://youtu.be/8mw-jZpmrsQ
The Most Accurate Total Testosterone Blood TestThe gold standard for accurately measuring total testosterone levels is high-performance liquid chromatography with tandem mass spectrometry (LC/MS-MS).
Recent studies have shown that the current assays used in total testosterone testing lack the required sensitivity to produce accurate results when working with very low concentrations.
This can be especially problematic when trying to accurately measure total testosterone levels in severely testosterone deficient men, normal or testosterone deficient women, and children.
In addition, these tests have proven via my own personal tests to detect synthetic anabolic androgenic steroids as testosterone.
This issue can be corrected by newer methods based on mass spectrometry.
The Most Accurate Free Testosterone Blood TestThe gold standard for accurately measuring free testosterone levels is equilibrium dialysis.
Equilibrium ultrafiltration is also sufficient.
A comparison of results obtained via equilibrium dialysis and equilibrium ultrafiltration found that the two methods correlated closely (r = 0.97) [R].
Direct analog enzyme immunoassay (EIA) is inaccurate and has shown in my own personal tests to detect synthetic anabolic androgenic steroids as testosterone.
My Blood Test Results Comparing ECLIA And EIA Vs. LC/MS-MS And Equilibrium UltrafiltrationThis is an example that very clearly shows how important high sensitivity testing can be.
I went in for a blood test during a Nandrolone-only experiment.
I had no Testosterone in my system whatsoever.
Expectedly, by assessing my Total Testosterone level via liquid chromatography with tandem mass spectrometry (LC/MS-MS) and my Free Testosterone level via equilibrium ultrafiltration, we can see that my Testosterone levels were crashed.
Both the total and the free were lower than a healthy female.
This is what you should see in your blood work if you’re on just Nandrolone.
The only Testosterone being produced in my body was indirectly via the trace amounts of androgens produced in my adrenal cortex, which is why the value wasn't completely bottomed out at 0.
I've mentioned many times the importance of getting high sensitivity testing done for hormone levels and how Nandrolone will register as Testosterone in primitive garbage blood tests.
This is another great example of this.
In addition to high sensitivity testing, I had the same blood tested using electrochemiluminescence immunoassay (ECLIA) for my Total Testosterone level, and direct analog enzyme immunoassay (EIA) for my Free Testosterone level.
These were the test results using the exact same blood sample with the terrible default assays that doctors will use to determine how to treat you, and that labs will give you in the majority of your blood work panels.
According to ECLIA and EIA, I had a normal Total Testosterone and Free Testosterone level.
This just one example of why getting accurate hormone testing is critical.
My Testosterone levels were actually in the gutter, but ECLIA and EIA couldn't even tell the difference between Testosterone and 19-nortestosterone in my blood.
Where To Order Accurate Blood TestsMost labs offer total testosterone (LC/MS-MS), and some offer free testosterone (equilibrium ultrafiltration).
However, very few self-pay labs offer free testosterone (equilibrium dialysis).
Of the ones that do offer it, it is extremely expensive and it does not come in a package with a total testosterone test.
If your doctor will write you a requisition for it, great.
If not, just get equilibrium ultrafiltration.
Personally, I drive to the US just so I can get LC/MS-MS and equilibrium ultrafiltration testing done.
This is the exact test I order every time to accurately check my testosterone levels: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS
https://youtu.be/i7erwHTh8OM
Contrary to popular belief, more is not better when it comes to exogenous GH use for fat loss.
There is a ceiling on lipolysis, and the highest GH dose for maximizing fat loss per administration is much lower than most people think.
As you can see here in the following study assessing the pharmacokinetics and acute lipolytic actions of GH, there were significant dose-response effects when comparing the incremental area under the curve of both free fatty acids and blood 3-hydroxy-butyrate following 0, 1, and 3 mcg/kg GH, whereas there were no differences between the responses following 3 and 6 mcg/kg GH [R].
These dosages were administered intravenously.
1 mg of Somatropin corresponds to 3 IU (International Units) of Somatropin [R].
So, this means that for someone who weighs 100 kg, lipolysis is maxed out at about 300 mcg of Somatropin, which is 0.9 IU’s of pharma grade GH IV.
We need to math out the corresponding subcutaneous dose based on the bioavailability and bioactivity comparison data we have on humans administered HGH.
Obviously IV dosages are not representative of what dosages would be via the far more realistic and tolerable method of administration (subcutaneous).
In one study, the mean estimated availability of subcutaneous injected HGH was shown to be 63% of that of HGH administered I.V. after correcting for differences in the GH dose [R].
Another study found the availability of subcutaneous injected HGH to be about 70% of that of HGH administered I.V. [R].
So, for a 100 kg man, fat loss benefits would be maxed out around 1.35 IU of GH per administration subcutaneously.
There is a refractory period cells need before another pulse of exogenous GH can even be useful in a lipolysis context, which I will delve into further in a future article.
At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis.
In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R].
Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression).
The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006).
IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis.
When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more.
The same thing happens with exogenous GH use.
When you administer exogenous GH, IGF-1 elevates.
When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner.
If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would.
When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing.
https://youtu.be/8j9MGfQPeXg
If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal.
There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible.
If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions.
Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste.
This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages.
RU58841 vs. Finasteride.
As of now RU58841 is the most commonly used topical anti-androgen used for hair loss prevention, and Finasteride is the most commonly used 5α-Reductase inhibitor for hair loss prevention.
Which is better for hair loss prevention?
This is a common question I get asked and a dedicated post is long overdue.
https://youtu.be/p39W1nBhxYE
Study Comparing RU58841 Vs. Finasteride Head To HeadWhile there are tons of anecdotal reviews comparing Finasteride to RU58841, there is very little scientific data for us to refer to.
There is some though that is worth delving into.
In this study, Finasteride was stacked up against RU58841 to see which would be more effective for hair loss prevention, and how much each would impact systemic hormone levels [R].
RU58841 was applied either in a 5% solution, a 0.5% solution, or just a vehicle with no RU58841 in it for 6 months to the bald scalp of 10 stump-tailed macaques.
The 5% solution was applied to 4 of the 10 bald stump-tailed macaques, the 0.5% solution was applied to 3 of the 10 bald stump-tailed macaques, and the vehicle with no RU58841 was applied to the last 3 of the 10 bald stump-tailed macaques.
The common dosing protocol for RU58841 is typically a 5% solution applied to androgenic alopecia affected areas, so this study was right in line with what we would want to see.
Oral Finasteride was given in a dose of 1 mg/kg/day for 6 months to 10 bald stump-tailed macaques.
An oral placebo was also given to 10 bald stump-tailed macaques.
Male stump-tailed macaques weigh on average between 9.7–10.2 kg, so that would equate to a Finasteride dosage of roughly 10 mg orally per day.
This dosage greatly exceeds the point of diminishing returns with Finasteride use, so this is also a great way for us to compare the efficacy of a standard dose of RU58841 to a maxed out dose of Finasteride.
The stump-tailed macaque has shown to be a suitable biological model for human androgenetic alopecia as it possesses hereditary balding characteristics similar in many respects to that of androgenetic alopecia in humans [R].
ResultsSkin biopsies for micromorphometric analysis (folliculogram) were taken at 0 and 6 months for Finasteride treated macaques and at 0 and 4 months for RU58841 treated macaques.
The amount of anagen follicles (hairs in the active growth phase) and vellus follicles (short, thin, and barely noticeable hairs) enlarged to terminal size were compared to those in pre-treatment stages.
Anagen follicles increased an average of 88% with Finasteride.
Anagen follicles increased an average of 103% with 5% strength RU58841.
The growth of vellus follicles to terminal size (thick, strong, pigmented hairs that have fully matured) was 12% with Finasteride.
The growth of vellus follicles to terminal size was 26% with 5% strength RU58841.
The 0.5% strength RU58841 solution induced almost no effect.
Expectedly, the Finasteride placebo induced no effect.
The 5% strength RU58841 solution induced the most hair growth after only 2 months of treatment.
RU58841 was given less time to work and still significantly outperformed Finasteride in this study.
Although Finasteride significantly reduced DHT levels, DHT remaining and produced by Type I 5α-reductase isoenzyme still contributed to hair follicle miniaturization.
Because Testosterone and DHT both bind to the androgen receptor, a locally sufficient dose of an "AR blocker" (topical anti-androgen) appears to suppress Testosterone and DHT induced follicular regression more effectively than 5α-reductase inhibition.
Systemic EffectsPlasma RU58841 and metabolites (10-20 ng/ml) were detected in 2 of the stump-tailed macaques that were applied the 5% strength RU58841 solution at the 3 month mark of treatment.
Only 1 of the stump-tailed macaques had detectable plasma RU58841 and metabolites at at the 6 month mark of treatment.
RU58841 had no significant impact on serum DHT or Testosterone levels at any point.
Finasteride decreased serum DHT levels by about 70%, and Testosterone levels increased as a result of the 5α-reductase blockade.
If Estrogen levels were assessed in the Finasteride treated group, their Estrogen levels would have showed significant elevation as well as a result of increased aromatization.
My Concluding Thoughts On This StudyThis study shows that RU58841 can go systemic when topically applied, although there is no effect on endogenous androgen levels.
First of all, I do believe that RU58841 can go systemic, in fact, I think it is an inevitable outcome.
However, the degree to which it goes systemic and if the amount that goes systemic will cause anti-androgenic side effects will be based on several factors.
These factors include but are not limited to endogenous androgen production, sex hormone metabolism, androgen receptor density and expression, scalp skin porosity, the dosage used, if there are open wounds on the scalp or not, the vehicle used, frequency of administration, and more.
Does this ensure side effects? No.
However, applying anything to your skin with a low enough molecular weight to be absorbed and not expecting it to go systemic at all is wishful thinking.
The molecular weight of RU58841 is 369.34 g/mol [R].
1 Da (dalton) = 1 g/mol.
The molecular weight of a compound must be under 500 Dalton to allow skin absorption (which RU58841 is) [R].
With that being said, RU58841 is well tolerated by the majority of users for a reason.
In the study, at the 3 month mark 2 of the stump-tailed macaques had detectable plasma RU58841 and metabolites.
By the 6 month mark, only 1 of the stump-tailed macaques had detectable plasma RU58841 and metabolites.
If there was a cumulative drug effect we would have seen more animals with detectable metabolites after an additional 3 months of dosing, not less.
What most fail to consider is that RU58841 is non-steroidal and acts as a competitive silent antagonist of the androgen receptor.
This means that even if RU58841 goes systemic, by creating a blockade of the androgen receptor, RU58841 prevents the negative feedback androgens would normally create via the hypothalamic–pituitary–gonadal axis (HPG axis) in men.
By binding to androgen receptors, RU58841 will induce anti-androgen effects without reducing serum androgen levels in the body.
Finasteride on the other hand works by directly crushing DHT levels rather than by occupying androgen receptors.
The ideal treatment would be a topical non-steroidal anti-androgen or SARM with a high binding affinity, and harmless metabolites void of anti-androgenic activity upon systemic absorption.
Achieving Complete Hair Loss Protection By Addressing The Androgen Receptor, Not Just 5α-ReductaseWhen you inhibit 5α-Reductase with Finasteride or Dutasteride, serum Testosterone and Estrogen levels increase will increase.
A common mistake is to ignore the fact that scalp Testosterone levels rise dramatically after inhibiting 5α-Reductase.
This occurs to an even greater degree with Dutasteride use, and I believe is the reason why some men experience accelerated hair loss after switching from Finasteride to Dutasteride.
Typically, most men will see better results with Dutasteride as scalp DHT is almost always going to be more of a problem than scalp Testosterone.
However, the consequent spike in scalp Testosterone levels with Dutasteride use is significant, and Testosterone will bind to androgen receptors and induce miniaturization just the same.
5 mg of Finasteride resulted in a 23% increase in scalp Testosterone levels with a concurrent 41% suppression of scalp DHT levels.
0.5 mg Dutasteride resulted in a 99% increase in scalp Testosterone levels with a concurrent 51% suppression of scalp DHT levels.
This is why the androgen receptor needs to be addressed, not just nuking 5α-reductase with Dutasteride.
Scalp Testosterone will still slowly chip away at your hair, regardless if DHT is there or not.
In addition, Finasteride is insufficient to completely eliminate scalp DHT, which also needs to be taken into account and addressed.
When you inhibit 5α-reductase, that Testosterone that would have otherwise converted to DHT doesn't just disappear, it remains as the parent hormone, thus raising total Testosterone levels in the body.
Dutasteride doesn't just randomly stop working one day, Testosterone and other endogenous androgens are still eating away at your hair, just at a much slower pace than DHT would.
The only way to prevent other androgens from binding to androgen receptors and miniaturizing hair follicles is by competing with them for androgen receptor binding.
That's where the therapeutic promise of topical anti-androgens, anti-androgens in general, selective androgen receptor modulators, and other similar compounds that bind to androgen receptors can come into play and provide a compounding level of protection when needed, or as a form of monotherapy on their own if sufficient.
If you only inhibit 5α-reductase with Finasteride, not only will you have residual amounts of DHT, but you will also have a spike in scalp Testosterone that is totally unaccounted for.
Unfortunately, you can't just partially inhibit 5α-reductase and expect complete protection for life unless you have very mild hair loss to begin with.
Permanent prevention can only be achieved by addressing the androgen receptor itself.
For some individuals, Finasteride monotherapy will be sufficient to stave off hair loss for a couple decades, but that residual DHT and spike in Testosterone will continue to chip away and eventually win in the end.
For some with aggressive hair loss, Finasteride monotherapy isn't even sufficient in the short-term.
At the end of the day, regardless of how aggressive your hair loss is, prevention is mediated via the androgen receptor.
Other treatment options may be implemented that interact with different downstream mechanisms in the cascade of events that lead to hair loss, but they will unlikely prove sufficient to completely mitigate androgenic alopecia on their own, and will be best utilized as an adjunct treatment to achieve a compounding level of protection with other compounds.
Which Is Better For Hair Loss Prevention?RU58841 and Finasteride work via different mechanisms of action.
They shouldn't be pitted against one another as neither are likely to prove sufficient to completely prevent hair loss on their own.
DHT has a much higher binding affinity than RU58841, but Testosterone doesn't.
Those with very aggressive hair loss would likely need to use a massive dose of RU58841 to compete with all of their scalp DHT and Testosterone.
On the other hand, Finasteride can significantly decrease DHT levels, but causes a subsequent spike in scalp Testosterone that goes completely unaccounted for that will still work in tandem with the residual DHT to miniaturize hair follicles.
A more complete level of protection would be achieved by using both Finasteride and RU58841, not one or the other.
Finasteride will significantly reduce the amount of scalp DHT, and leave a hormonal environment that RU58841 is more capable of dealing with.
RU58841's binding affinity is at least as high as Testosterone, so if most of the DHT is cleared out of the way, RU58841 only has to compete with Testosterone and a much lower amount of DHT.
Expecting RU58841 to out-compete all endogenous DHT and Testosterone without any assistance when its binding affinity is several times lower than DHT is a strategy that would likely only work long-term for someone with mild hair loss.
The dose and frequency of administration relative to the half-life needs to be kept in mind as well.
There's a dose-dependent response with all drugs, including anti-androgens.
Just because a 5% RU58841 solution applied once per day proves sufficient for one guy, that doesn't mean that dosage will be sufficient for you too.
Hair loss is basically just a giant chess match where the most efficacious treatments will either knock out the opponent (decrease endogenous androgen levels), or occupy a more advantageous position on the chess board (binding to androgen receptors).
The more chess pieces you have, the better your chance of winning against the finite number of opponent chess pieces.
This is why certain anti-androgens with very poor binding affinity can still be effective in a clinical setting.
An anti-androgen dosed very aggressively will eventually overpower Testosterone and DHT just by sheer volume (e.g. Bicalutamide).
The same applies for RU58841, assuming it gets absorbed, which will boil down to scalp skin porosity, vehicle, and so on.
If you opted for CB-03-01 instead of RU58841, the same concept would apply, it would just need to be dosed even more aggressively until sufficient AR binding is achieved.
For those prone to side effects, that strategy may be the better alternative with CB-03-01 rather than RU58841 as it seems that the metabolites of CB-03-01 may be better tolerated at higher dosages than those of RU58841.
The binding affinity of CB-03-01 is much lower than RU58841 though and it is very cost prohibitive, so for the time being, that strategy is likely not viable for most.
Where To Buy RU58841Most RU58841 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.
I strongly advise that before you buy RU58841 from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.
These are the only companies I currently use for my own personal research:
(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)
Science.bio – 10% off coupon code “DC10”
Chemyo – 10% off coupon code “DC10”
Anageninc - 5% off coupon code "DC5"
This article will be a continually updated log for my injectable SARMs cycle and review of injectable LGD-4033 (Magnalone).
Rather than publish a separate article for each update, I will come back and update this article accordingly with any blood work or new findings.
For those that are just here find out where to buy injectable SARMs, these are the only companies I currently use for my own personal research:
Swiss Chems – 11% off coupon code “DC11”
The Goal Of This ExperimentIn my log introduction I outlined the goal of this experiment.
https://youtu.be/F3L7xhE6tlM
My goal of this experiment was to truly evaluate how anabolic injectable SARMs are without any interfering factors.
To be more specific, I wanted to find out if injectable LGD-4033 could "replace" a TRT dose of Testosterone entirely in a muscle growth/retention context.
If injectable SARMs could replicate the same muscle building potential as traditionally used anabolic steroids with a fraction of the androgenic activity, the potential applications would be endless.
LGD-4033 is purported to have a 500:1 anabolic to androgenic ratio.
The following graph illustrates the data derived from the preclinical studies which exhibits how much LGD-4033 stimulated muscle growth relative to prostate growth in comparison to Testosterone.
LGD-4033 Selectivity For Muscle To Prostate Compared To TestosteroneLGD-4033 stacked up against Testosterone very well in the preclinical models with a greater than 500x tissue selectivity of muscle to prostate.
As LGD-4033 is so tissue selective, individuals who are extremely prone to the androgenic side effects of Testosterone may be able to utilize LGD-4033 as a way to build supraphysiological amounts of muscle mass, or retain it, with a relative absence of those same side effects.
How I Determined Exactly How Anabolic Injectable LGD-4033 Is By Utilizing Exogenous EstradiolMost guys using injectable SARMs are using them alongside a Testosterone base at minimum.
To truly evaluate the efficacy of injectable LGD-4033 in an anabolism context, all other androgens would need to be removed from the equation.
As I just finished a Nandrolone monotherapy experiment prior to starting LGD-4033, my endogenous androgen production was completely shutdown.
Estrogen is what has shown to be neuroprotective and not Testosterone (and potentially cardioprotective as well).
Estrogen also supports several other functions in the body that would be inhibited if I were to forgo Estrogen replacement during this experiment.
These include but are not limited to muscle growth and fat loss.
I needed to isolate LGD-4033 and keep myself shut down to accurately assess how anabolic it is, so adding an exogenous aromatizing compound was not an option.
The most common solution to insufficient Estrogen would be a Testosterone base, DHEA, HCG, or an aromatizing anabolic steroid like Dianabol or Trestolone to act as a makeshift "Test base".
None of these were viable options as they would add anabolic and androgenic activity to my body and skew my findings.
The only option was to utilize exogenous Estradiol at a physiologic dose.
This is because exogenous Estradiol would prevent my natural Testosterone production from turning back on (endogenous Testosterone production would also skew my findings), it would activate Estrogen receptors sufficiently to bandaid the issue of insufficient aromatization to fulfill physiologic functions, and it would not elevate androgenic activity in the body at all.
In theory, by maintaining a physiologic level of Estrogen in the body I could largely avert the inhibition of anabolic pathways and assess exactly how anabolic LGD-4033 is with no factors interfering.
The only potential drawback here is that aromatase is what normally regulates Estrogen production endogenously, and by bypassing this process entirely I could very well be missing out on some downstream anabolic pathways that would otherwise be fulfilled by Testosterone aromatizing into Estrogen.
Just one of these being the IGF-1 pathway.
The experiment is not perfect, but it is the closest I am going to get to it.
Prior to my Nandrolone experiment I was maintaining my physique on 100 mg of Testosterone per week, and I was able to retain the same level of muscle mass and strength during my Nandrolone experiment with no other factors changed.
If injectable LGD-4033 proved capable of maintaining my physique with no factors changed in my diet or training, then I would know that it is at least as anabolic as Testosterone and Nandrolone, but with a fraction of the androgenic activity.
Oral SARMs Vs. Injectable SARMsOral SARMs have shown to have a handful of common side effects in a clinical setting, with numerous other side effects cropping up when utilized in a performance enhancing context at higher dosages.
The main side effects that are consistently seen both clinically as well as anecdotally with oral SARMs are:
https://youtu.be/Lhis3HWWKbQ
Other less common side effects start to crop up once the dosage used greatly exceeds what has been evaluated on humans clinically.
The potential benefits that injectable SARMs have over oral SARMs mainly come down to increased bioavailability and skipping the first pass effect in the body after administration.
BioavailabilityMany SARMs have undisclosed oral bioavailability and are presumed to be low based on the lack of published data.
Obviously this isn't a scientific way to go about determining a SARM's oral bioavailability, but until these pharmaceutical companies start to release more transparent data, researchers will speculate and make assumptions that could be true, or could be way off.
Some SARMs have shown to have reasonable levels of oral bioavailability, but we don't have exact figures for the majority of them.
The closer a SARM is to 100% the closer it is to complete absorption after oral dosing.
With injection, complete bioavailability is guaranteed as we are basically forcing the body to assimilate it into the blood and carry it to target tissues, whereas with oral administration we are giving the body's oral drug metabolism an opportunity to break down the compound however it sees fit.
By ensuring complete bioavailability with injection, we may be able to minimize the dosage required to yield a desired effect.
In theory, this should result in less side effects and more anabolic activity milligram for milligram.
This is the first potential benefit of injectable SARMs over oral SARMs.
In some cases, like with SR9009 (not a SARM but is commonly lumped into the "SARMs" category), the body nearly completely breaks it down when it is administered orally, rendering it ineffective.
Some oral SARMs are very bioavailable as is and we do have the data to reinforce that.
For example, the SARM S23 is 96% orally bioavailable [R].
This means that S23 can be administered orally, as opposed to requiring injections to achieve maximal blood serum concentration levels, which is obviously advantageous when it comes to ease of use and adoption.
The First Pass Effect - Drug MetabolismDespite having nearly 100% bioavailability, oral S23 administration may have a completely different effect in the body simply by injecting it.
The same could apply for any other SARM too, not just S23.
After a drug is swallowed, the digestive system absorbs it and it enters the hepatic portal system.
Afterwards, the portal vein carries it into the liver for metabolization, which then essentially regulates how much is filtered out prior to delivery to the circulatory system for delivery to target tissues.
Not only can this process greatly reduce how much of a drug actually gets through for utilization, but it can produce a variety of side effects that wouldn't occur with methods of administration that skip the first pass.
Methods of administration like transdermal delivery or injection skip the first pass and can avoid the hepatotoxicity often associated with oral drug metabolism, as well as other side effects that can stem from the drug metabolism process itself.
More often than not, this is a good thing.
However, in the case of anabolic agents, it seems that the first pass can actually be responsbile for the potentiation of certain compounds, rather than the other way around.
You can see how this can start to make injectable SARMs vs. oral SARMs murky territory, as we basically need to experiment with it ourselves to see if the increased bioavailability and skipping the first pass improves the anabolic activity relative to the side effect profile of SARMs, or makes it worse.
For what it is worth, as of now the results seem promising, with the majority of individuals noting only drastically increased levels of anabolic activity at lower dosages, and less side effects.
However, regardless of how promising and exciting this may seem, we need to consider the possibility of negative outcomes and not let the hype around injectable SARMs shroud our judgment.
Examples Of How The First Pass Effect Can Greatly Impact Drug EffectsThe following are two examples of how drastic of a difference just changing the method of administration can have when it comes to a drug's effects on the body.
The first shows how injectable and transdermal estradiol was superior to oral estradiol, and the second shows how oral Superdrol was superior to injectable Superdrol (in a tissue selectivity context, not a hepatotoxicity or lipid dysfunction context).
Oral Estrogen Vs. Transdermal Or Injectable EstrogenA few of the most notable drawbacks of oral estrogen pills are that they can be somewhat liver toxic, they significantly spike SHBG levels, and they result in the production of clotting factors in the blood that do not develop with forms of administration that skip the first pass.
Also, the ratio of Estrone-to-Estradiol is skewed with massive elevations in Estrone with oral Estrogen administration.
None of these issues occur with transdermal topical application, or injection.
High levels of serum Estrone sulfate (E1S) were found after long-term oral estrogen treatment of commonly prescribed dosages, whereas there was a small increase in E1S levels after transdermal Estradiol (E2) therapy.
The mean maximum E1S levels were more than 20-fold higher with oral estradiol (E2) when compared with the 0.05 mg/day transdermal estradiol patch.
This is consistent with the 20-fold higher dose of E2 when compared with the transdermal dose [R].
Oral estrogen also has very low bioavailability, thus requiring a much higher dosage to achieve the same effect that could be achieved with a much lower dosage of injectable estrogen.
Oral Superdrol Vs. Injectable SuperdrolNot only is the side effect profile of oral Superdrol compared to injectable Superdrol substantially different, but even its anabolic to androgenic ratio changes based on the method of administration.
When administered orally, Superdrol was more anabolic than methyltestosterone and several times less androgenic than methyltestosterone.
Methyltestosterone has an anabolic to androgenic ratio similar to that of testosterone (close to 1:1).
When administered via injection, Superdrol was nearly twice as anabolic as testosterone and twice as androgenic as testosterone.
The results of subsequent assays to determine Superdrol's anabolic and androgenic activity found that that Superdrol possessed the oral bioavailability of methyltestosterone while being 400% as anabolic and 20% as androgenic, yielding an anabolic to androgenic ratio of 20:1 [R].
In the case of Superdrol, injecting it actually made it less tissue selective, despite oral administration having the obvious drawback of lower bioavailability and hepatotoxicity.
My Daily Injectable LGD-4033 And Estradiol DosageAs the goal of this experiment was to determine the lowest effective dose of LGD-4033 that could replicate the same anabolic activity as 100 mg of Testosterone per week and 100 mg of Nandrolone per week, my dose was much lower than what most are utilizing in their own experiments.
Once I could determine the lowest effective dosage, I could evaluate the side effect profile of that dosage, how my blood work looks on that dose, how I feel, and then make an informed decision about the overall efficacy profile of injectable LGD-4033 based on all of those factors.
As injectable LGD-4033 is more bioavailable, the dosage required to replicate the anabolic activity I was shooting for would likely be much lower than you would expect via oral dosing.
I spoke to Tony and Trevor about this experiment and asked for their feedback on what dose they think I should start at.
They were the two who brought injectable SARMs to my attention in the first place, and nobody else I know had any experience with them at the time.
At 7:02 in the following video Tony and Trevor are referring to me, and that is partially what influenced my decision to go with 3 mg per day as my daily dose.
https://youtu.be/F2OcSnQZ99Q?t=422
I also applied 2.5 grams of transdermal Estrogel (delivering 1.5 mg Estradiol) per day for the first couple weeks.
I got my blood test results back from my Nandrolone experiment a couple weeks into my LGD-4033 experiment which showed that I was absorbing Estrogel very poorly, which prompted me to switch to oral Estradiol pills.
Ideally I would have switched to Estradiol injections, but I did not have any injectable Estradiol on hand, so I was forced to use oral pills if I wanted to maintain an optimal Estradiol level throughout the experiment.
Injectable LGD-4033 Half-Life And Dosing ScheduleOrally, LGD-4033 displayed a prolonged elimination half-life (24–36 hours), linear pharmacokinetics, and predictable accumulation with multiple dosing [R].
There was a dose-proportional increase in LGD-4033 concentrations on days 1 and 21 because of its long half-life.
Serum LGD-4033 concentrations were nearly threefold higher on day 21 than on day 1, reflecting accumulation upon multiple dosing.
There is not any human data we can refer to that evaluates the pharmacokinetics of injectable LGD-4033, so any statements made about how often it should be dosed are largely based on speculation and educated guesses.
Tony and Trevor believe that injectable LGD-4033 can be dosed every other day and still maintain stable blood serum concentrations.
https://youtu.be/1aTQWN3ML3U
For the sake of ensuring stability once dose saturation was reached, I maintained a daily dosing schedule from day 1 where I administered 3 mg every 24 hours.
Muscle Growth And Strength Levelshttps://youtu.be/Iq-fm1qJ5To
How I assess if something is working or not is by comparing it to my previous baseline metrics I have established on a therapeutic dose of TRT.
If I suddenly start getting stronger while using the exact same diet and training regimen with the only factor changed being a drug, I can logically conclude that the drug is stronger milligram for milligram than my baseline on TRT.
By now, I know exactly how my body responds to 100 mg of Testosterone per week, as well as 100 mg of Nandrolone per week.
After swapping to injectable LGD-4033 with no other factors changed, it was very easy to assess if there were any positive or negative changes in my body composition or strength.
Other than feeling a bit deflated, I didn't experience any changes in my strength or size.
My weight stayed exactly the same, my strength stayed exactly the same, and my body composition stayed the same, with the exception of being a bit flatter.
Perhaps the reason I'm flatter is that LGD-4033 has less "off target" activation than something like Testosterone and Nandrolone, whereby they can increase intramuscular fullness via indirect mechanisms.
That is just speculation though.
At the end of the day, I haven't lost any contractile tissue, which is the most important thing to note.
I believe that a relatively low dose of injectable LGD-4033 is at least as anabolic as 100 mg of Testosterone per week or 100 mg of Nandrolone per week.
While this is promising for those on TRT or who use "low" dosages of anabolic steroids, the main drawback we have seen in the past with oral SARMs is that the ceiling where diminishing returns starts to set in is far lower than with anabolic steroids.
Whether or not injectable LGD-4033 has that same drawback remains to be seen.
Anecdotally, other users have reported that the ceiling of diminishing returns is much higher with injectable LGD-4033, but I cannot confirm or deny this myself as that is beyond the scope of my experiment (at least for now).
My only hope for this experiment was that I could retain all my muscle with just a SARM, which I did.
I may consider a "blast" phase in the future where I titrate the dose up and evaluate how well it can support supraphysiological muscle growth, but that will be dictated by its androgenicity in practical application.
Injectable LGD-4033's androgenicity still needs to be explored more via further experimentation, as I did have a few red flags of androgenic activity that have me a bit hesitant to utilize a higher dose.
If injectable LGD-4033 is as tissue selective as the clinical data has shown, there are several doors that open up in a bodybuilding and hair loss prevention context.
Side Effects Changes In LibidoMy sex drive went up substantially after swapping Nandrolone out for LGD-4033.
Many were quick to comment on my YouTube video about how exogenous Estradiol (E2) is the reason why my libido spiked.
I was already on exogenous Estradiol prior to the injectable LGD-4033 for my Nandrolone-only experiment.
I have been on the same dose of transdermal E2 for almost 3 months, the only thing that changed was swapping NPP out for LGD.
The libido change was from the swap.
No other factors were changed.
After I switched from transdermal Estradiol to oral Estradiol, my libido was no different either.
The change in libido occurred almost overnight after adding LGD-4033 in.
Several other individuals have come forward since that video was published reporting that injectable LGD-4033 increased their libido as well.
They were all using a dose at least 5-10x higher than I was, but it is still notable nonetheless.
As LGD-4033 is supposed to be so tissue selective and have such a lack of androgenicity I was very surprised that my libido spiked.
If anything, I was expecting my libido to drop.
With a 500:1 anabolic to androgenic ratio, obviously you wouldn't expect one of the biggest red flags of androgenic activity to spike.
Keep in mind, 100 mg of Nandrolone per week is not nothing.
Despite Nandrolone being one of the least androgenic steroids ever developed (if not the least of the mainstream anabolic steroids), 100 mg per week has shown to be a high enough dose to cause virilization in women.
Within 12 weeks, some women will experience virilization on Nandrolone even using only 100 mg every 2 weeks.
When duration of use exceeds a year, significant virilization in women is found even at a dosage of only 50 mg every 2 weeks.
My libido doubled after switching from NPP to injectable LGD-4033, which is a red flag and should be noted.
My libido isn't as high as it is on 100 mg per week of Testosterone, but it is significantly higher than on Nandrolone.
Hair LossI noticed an increase in shedding using injectable LGD-4033.
However, less than 10% of the hairs I shed are miniaturized.
This leads me to believe that it is less likely to be androgenic alopecia, and is more likely telogen effluvium caused by the massive hormone fluctuation I put my body through by switching from TRT to a Nandrolone only protocol, and then subsequently switching from Nandrolone to injectable LGD-4033.
Further experimentation will be needed before I have a concrete conclusion on the androgenicity of injectable LGD-4033.
If it ends up being hair safe, there are several applications I have in mind for this compound.
Not only would it be a potent androgen receptor agonist for use in a bodybuilding context, but it could also be utilized during a hair recovery phase.
For example, if you have any androgenic alopecia, periodically switching to SARMs with exogenous Estradiol (or an Estrogen precursor) in cycles could be a way to maintain muscle built via supraphysiological steroid use in the past, while reducing the androgen load on the scalp significantly enough to allow for regrowth.
Or, if you don't use steroids, it could serve as a means of recovering hair lost via endogenous androgen induced miniaturization by reducing androgenicity below baseline periodically throughout the year.
Basically like a makeshift anti-androgen that won't strip the muscle off your body.
These are hypothetical examples, but these are just a few of the potential applications I see for SARMs in the future.
Changes In Body Hair GrowthThis one was a metric I should have kept a closer eye on, but I usually manscape every single week so it wasn't something I originally planned on evaluating.
A few weeks into my LGD-4033 experiment I noticed that my body hair seemed to be growing a bit faster than usual.
Whether this was in my head or not, I'm not positive as I was not even planning on using this as a metric, but I got backlogged on work throughout the holidays and ended up skipping my weekly manscaping sessions.
While it may not be fair to say for certain that LGD-4033 increased my rate of body hair growth, I can confidently say that at the absolute least, it did not reduce my body hair growth.
This is notable as well because I had no androgens in my body.
If I only had Estrogen in my system and no androgens I would notice a drastic reduction in body hair growth and libido, just like transgenders who transition from male to female.
The only anabolic compound in my body throughout this entire experiment was injectable LGD-4033, and I didn't notice a reduction in androgenic activity via body hair growth either.
When I crushed my DHT levels to 0 with Dutasteride, I noticed a significant reduction in back hair growth.
On injectable LGD-4033, I did not notice a reduction in body hair growth at all.
However, on Nandrolone I did not experience a significant reduction in body hair growth either, despite it dramatically reducing my libido.
While this metric isn't a scientific way to assess androgenic activity, in general, the body can tell you pretty accurately when androgenic activity is high or low when sufficient Estrogen is present to support erections.
Increase the androgenic activity in your body and you will likely experience an increase in libido, an increase in scalp hair loss, and an increase in body hair growth (in general).
Decrease the androgenic activity in your body and you will likely experience a decrease in libido, a decrease in scalp hair loss, and a decrease in body hair growth (in general).
Changes In Blood PressureMy blood pressure on injectable LGD-4033 is identical to what it is normally on TRT.
My blood pressure on injectable LGD-4033 and TRT is far better than it is on Nandrolone.
For whatever reason, Nandrolone has a unique negative impact on systolic blood pressure, making it difficult to maintain healthy levels.
On only 100 mg of NPP per week my systolic blood pressure was consistently 125-128 eating the exact same diet I was on TRT and LGD-4033.
So far so good in regards to blood pressure on injectable LGD-4033 though.
Changes In Resting Heart RateMy resting heart rate did not increase on injectable LGD-4033 and is no different than what it is on TRT.
Potential In Preventing Or Reversing Cardiovascular Issues Caused By Steroid UseEven if injectable LGD-4033 does not end up being as purely anabolic as we hoped, there is another very promising application I see for injectable SARMs that is largely overlooked.
That is the potential lack of heart stimulation.
Anecdotally, many users have reported far better outcomes using SARMs than anabolic steroids in a cardiovascular health context.
One example is a friend of mine, Alek Mitrevski.
He used 100 mg of oral S4 (Andarine) with 0.5 mg oral Estradiol per day for over a year straight.
During that time he did not experience any cardiac hypertrophy, LVH, or any kind of deleterious effect on his cardiovascular system.
At the start of 2019 Alek ran a high dose Deca only cycle with Anadrol intermittently added in.
https://youtu.be/qDgk7XLcqqU
Within 9 months, he experienced significant thickening and enlargement of his heart.
He switched back to SARMs only to try and reverse this damage while maintaining the muscle he built with the Deca + Anadrol blast.
Although the reports are obscure and not well documented, I have seen a handful of individuals report the reversal of cardiomyopathy and LVH after switching to SARMs only.
SARMs are supposed to be tissue selective, whereas anabolic steroids have shown to significantly impair cardiac health.
The potential applications this may have for athletes seeking supraphysiological muscle growth with a minimization of cardiac hypertrophy, LVH, etc. makes injectable SARMs worth further exploration in itself.
Athletes seeking to reverse cardiovascular issues as a result of past AAS abuse while maintaining most (or all) of their hard earned muscle mass would also be strong candidates for benefiting from injectable SARMs if the hype around them turns out to be justified.
My Blood Test ResultsI will be updating this section with my blood test results in the near future.
Reviews From Other UsersI have curated all of the injectable LGD-4033 reviews I could find and included them here for your reference as well.
https://youtu.be/rJFmwpPvBfQ
https://youtu.be/c1BWS-sP7nM
The following comments weren't reviews about injectable LGD-4033 specifically, but they were relevant to include nonetheless:
ConclusionSome of the classic signs of androgenic activity are red flags worth keeping an eye on.
But other than that, so far so good.
I feel good, I am not depressed and have not experienced any negative mental or physical side effects so far despite the near complete absence of Testosterone and DHT in my body.
The fact that injectable LGD-4033 has proved capable of maintaining the same amount of muscle and strength that I could maintain on 100 mg of Testosterone per week and 100 mg of Nandrolone per week is a good sign.
I was hoping for that outcome, and expecting more than that is wishful thinking.
If a relatively low dose of injectable SARMs can replicate the same anabolic activity of traditionally used steroids, then it is absolutely worth further experimentation.
I'm going to continue digging into injectable SARMs, and I look forward to seeing more data come from other researchers in the community as well.
This is a very promising area of research, and I hope that more individuals start to come forward with their personal findings too.
I'll keep you guys updated, but that is where we're at with my injectable SARMs experiment so far.
Where To Buy Injectable SARMsI strongly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.
These are my current go to companies for injectable SARMs:
Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.
There's been a growing amount of hype around the "Deca only cycle".
While it is most commonly referred to as the Deca only cycle, it is actually based on the compound Nandrolone being used on its own.
The decanoate ester being abbreviated as "Deca" has just become synonymous nowadays in the bodybuilding community with Nandrolone itself.
Seeing the potential merits of Nandrolone as a makeshift hormone replacement therapy alternative to Testosterone, I stopped using Testosterone and instead started using Nandrolone on its own with exogenous Estradiol for 3 months and paid over $1000 for an elaborate blood panel to assess how it affected my health markers.
https://youtu.be/kLScNddgkks
How Nandrolone Could Potentially Be A Superior HRT Alternative To TestosteroneThe primitive thought process is that Nandrolone used in conjunction with Testosterone will lead to horrible side effects, but Nandrolone used on its own will just result in all of the benefits of steroids with a near absence of the androgenic or estrogenic side effects associated with Testosterone use.
In reality, it's a lot more nuanced than that.
The reason why I found this experiment worth pursuing is the lack of androgenicity of Nandrolone in the body.
Nandrolone 5α-reduces in tissues that express 5α-reductase to the much less androgenic metabolite Dihydronandrolone (DHN).
Nandrolone is basically the only anabolic steroid that is going to maintain 100% anabolic activity of the Nandrolone in muscle tissue where you want it, but also be converted into a much less androgenic metabolite with a lower binding affinity in certain areas of the body where you wouldn't want Nandrolone to bind.
The two areas of concern for most individuals being hair follicles and skin.
By converting to DHN in these areas, Nandrolone (and by extension DHN) causes less hair loss and acne than Testosterone (and by extension DHT).
In addition, some men are genetically predisposed to high levels of aromatization and estrogen receptor expression and can't even use TRT doses of Testosterone without experiencing estrogenic side effects.
Nandrolone is not a potent substrate for aromatase, and mainly converts to a weaker estrogen called Estrone (Estradiol is about 10-fold more potent than Estrone).
Nandrolone is also mildly estrogenic on its own via its ability to act as an estrogen receptor alpha (ERα) agonist [R].
Overall, Nandrolone is much less androgenic and estrogenic than Testosterone, and may provide symptom relief in those seeking a viable hormone replacement therapy alternative.
In this context, Nandrolone may also have great potential as an efficacious alternative to Testosterone as an anabolic agent for some individuals who are prone to androgenic and/or estrogenic side effects.
The Neurotoxicity And Cardiotoxicity Of NandroloneBased on the limited data available, Nandrolone has shown to be more deleterious to cardiovascular and neurological health than testosterone.
https://www.youtube.com/watch?v=Gv_v0mJy6Bg
By extrapolating the data, we start to get a clearer picture as to why this likely is.
Nandrolone is mildly estrogenic on its own, and it does not aromatize nearly enough to create as much Estradiol as Testosterone does.
Comparing the effect of testosterone with that of 19-nortestosterone (Nandrolone) and Stanozolol (Winstrol) on neurotoxicity we can clearly see that Estrogen is what protects neurons in the brain, not Testosterone itself.
In this study, a physiologic dosage of Testosterone was neuroprotective [R].
Testosterone only amplified neurotoxicity at supraphysiological dosages.
The neuroprotective effect of a physiologic dosage of Testosterone was completely eliminated when the aromatase inhibitor Anastrozole (Arimidex) was co-administered, suggesting that the intrinsic toxicity of Testosterone as an androgen is only counterbalanced by its aromatization into 17β-estradiol.
As opposed to testosterone, Nandrolone does not appear to aromatize sufficiently into estrogen.
As you would expect, Nandrolone was neurotoxic at every single dose evaluated regardless of Arimidex being co-administered or not.
If Nandrolone was inherently able to provide enough estrogen receptor alpha (ERα) activation to balance out its androgenicity without even requiring aromatization (it acts as an estrogen on its own to some extent), we would see a neuroprotective effect at equivalent dosages to a physiologic concentration of Testosterone when no AI is used, but that does not appear to be the case either.
The anti-androgen flutamide attenuated the neurotoxicity of all three androgens, thus further reinforcing that physiologic dosages of androgens without a sufficient amount of opposing estrogens, or supraphysiological dosages of androgens may facilitate neuronal death.
I suspect that the same applies for the inherent cardiotoxicity of Nandrolone as well.
Just because you can get your Estradiol levels up to 15 pg/mL with a gram of Deca only, that ratio of androgens to estrogen in the body is way off of what would otherwise be optimal for health based on what I've seen.
This is reinforced by the fact that Flutamide (an anti-androgen) was able to attenuate the neurotoxicity of Nandrolone.
By preventing Nandrolone from binding to androgen receptors, it is no longer able to transcribe its effects in tissues.
Hair loss and acne are one thing, cardiotoxicity and neurotoxicity are another thing and should ultimately take precedence obviously.
However, just because Nandrolone monotherapy cannot produce a sufficient ratio of androgens to estrogens, that doesn't mean that there isn't a potential loophole.
That loophole is exogenous Estradiol administration.
Exogenous Estradiol Use With Nandrolone Only CyclesAs we've seen, Estrogen produced via aromatase is what provides neuroprotection from the androgenicity of Testosterone, not the Testosterone itself.
We also know that Nandrolone is not able to produce enough estrogenic activity in the body to facilitate this same level of neuroprotection.
I theorize that Nandrolone in conjunction with exogenous Estradiol to replace this otherwise missing component could attenuate a significant amount of the deleterious impact Nandrolone has on the heart and brain.
In addition, by providing a sufficient amount of exogenous estrogen, libido, muscle growth, fat loss, and several other aspects of health and performance should be more optimized.
It isn't a coincidence that cardiovascular disease rates skyrocket once women hit menopause and stop producing Estrogen properly.
The same negative effects will apply in men with low Estrogen levels.
The lack of sufficient Estrogen is often addressed in Deca only cycles by adding an adjunct anabolic steroid that aromatizes into Estrogen or Estrogen analogs.
Obviously for those seeking to minimize androgenic side effects, the ideal way to go about achieving sufficient Estrogen receptor activation is probably not going to be by adding more steroids to their protocol.
This is where exogenous Estradiol comes into play, and I believe the majority of Deca only cycles would be more sustainable from a health perspective, and successful in a bodybuilding context as well with its inclusion.
I have yet to see one person on a Deca only cycle achieve a sufficient Estradiol level relative to their Nandrolone dosage via a sensitive assay Estradiol blood test.
The following blood test result was submitted by an individual on over 1000 mg per week of Deca only.
Over a gram of androgens relative to a 19.2 pg/mL Estradiol level is far from ideal in my opinion.
I had a good conversation with Vigorous Steve as well about his Deca only cycle experience.
He told me that his Estradiol was 12 pg/mL on 1000 mg of Deca per week after 4 weeks, and he ended up adding 25 mg DHEA per day just to bring it up to 25 pg/mL.
When it comes to Nandrolone use on its own, most would benefit from more Estrogen in my opinion.
My Weekly Nandrolone And Estradiol Dosage For "HRT"Most guys doing Deca only cycles are evaluating Nandrolone at dosages of 600 mg or higher per week for short blasts.
My experiment was based on its potential as an alternative long term HRT option for those prone to androgenic side effects.
Or alternatively, its potential as a compound to swap to periodically throughout the year from TRT to reverse some of the androgenic side effects of Testosterone and DHT while still maintaining the same amount of muscle mass.
Every blood test I've seen of Deca only cycle users was on high doses of Nandrolone without a sufficient amount of Estrogen.
I wanted to see how Nandrolone on its own at a "therapeutic dose" would affect my blood work if I had a sufficient amount of Estrogen provided through exogenous Estradiol.
Long-term, the only way Nandrolone monotherapy could be even relatively safe in a cardiovascular context would be with exogenous Estradiol supplementation from what I've seen.
And even then, I'm sure it has major drawbacks that will likely accumulate over the years.
With that being said, it is still something I wanted to explore nonetheless, as it is one of the few compounds that can actually support supraphysiological muscle growth with a relatively minimal impact on androgenic alopecia.
Oral micronized Estradiol tablets have quite a few drawbacks.
A few of the most notable drawbacks are that oral Estrogen pills can be somewhat liver toxic, they spike SHBG through the roof, and they result in the production of clotting factors in the blood that do not develop with forms of administration that skip the first pass.
The two most viable methods of administration that skip the first pass are transdermal topical application, or injection.
I chose to topically apply transdermal Estradiol gel (Estrogel) for this experiment.
I used 100 mg of Nandrolone phenylpropionate (NPP) per week split into daily injections using an insulin pin rotating between my glutes and ventroglutes.
I also applied 2.5 grams of transdermal Estrogel (delivering 1.5 mg Estradiol) to my inner thighs every day for over 3 months straight.
Blood Pressure Changes On NandroloneOne of the first things I noticed was that it was a struggle to keep my blood pressure in check on NPP, even at the mild dose I was using.
What that was caused by exactly, I'm not sure.
I assumed it was Aldosterone prior to this blood work.
When I'm on Testosterone, even when I was using TRT as high as 200 mg per week, I could keep my blood pressure at 110/70 with ease.
Even if I ate terribly, I could still hold 115/75 without even trying on Testosterone.
Within the first week of switching to NPP it became way harder to control my systolic blood pressure.
My diastolic blood pressure was fine for the entire 3 months, but my systolic blood pressure would consistently be around 125-128.
That is not normal for me, and is borderline stage 1 hypertension.
The fact that I even had to try to lower my blood pressure showed to me that Nandrolone is a lot harder to manage in this regard.
This is consistent with almost every single person I know who has blasted high doses of Deca.
They all had significant issues with blood pressure.
Most of the guys who thought they had normal blood pressure were actually stage 1 hypertensive and didn't even realize that their results were indicative of cardiovascular stress.
My 125-128 systolic occurred without being in a calorie surplus, without any weight changes, and on what I would consider a very low dose of NPP.
The exact same diet, weight, lifestyle, etc. would have me at 110/70 on TRT.
Muscle Growth And Strength On NandroloneI maintained my muscle and do not feel that there was a substantial difference between the anabolic potency of Nandrolone compared to Testosterone.
At the very least, the anabolic activity of Nandrolone is comparable to Testosterone, but the androgenic activity is far less than that of Testosterone.
In certain contexts for certain individuals, Nandrolone will be the desirable alternative because of this.
Reduced Libido On Nandrolone - Deca Dick?My libido was extremely subdued on NPP.
That's one of the most obvious things I noticed during my experiment.
I had a libido and would still want to have sex, but my libido was much lower than it is on regular TRT.
On TRT I can barely go one day without sex before it starts to consume my mind.
On Nandrolone only, I can easily go a couple days barely even thinking about it.
However, when it came time to get the job done, I could still get the job done and stay hard the entire time without any issues in erection quality.
It was a bit harder to reach orgasm though.
On top of the lack of androgenicity causing a reduction in libido, Nandrolone also has progestogenic activity and binds to the Progesterone receptor.
Excessive Progesterone is notorious for killing libido and causing erectile dysfunction, and it seems that Nandrolone has similar effects in many individuals via this pathway in conjunction with its 5α-reduction into DHN.
My drive was also lower, and I felt less aggressive overall.
In many individuals Testosterone and DHT levels will strongly influence libido, drive, aggression, motivation and productivity.
Personally, even if I have that support via DHT or DHT derivatives, the increased motivation and drive is actually more counterproductive in a work productivity context because my libido gets way too high.
Even when I had high testosterone levels and 0 DHT in my body I still had sex on my mind far more than I would like.
When that happens, I can barely get anything done, and then I end up depleting myself of energy for the day through excessive sex.
The subdued and normalized libido on Nandrolone is welcomed for me because of this.
I don't think this is necessarily just because I'm a good responder to Nandrolone, I think it has more so to do with the fact that I was using exogenous Estrogen during this experiment with the Nandrolone.
Despite androgens driving aggression and drive, libido and erection quality is largely dictated by adequate Estrogen levels.
With all that being said, DHT (with sufficient Estrogen via Testosterone aromatization) is blatantly better for sexual support than Nandrolone, and testosterone itself, even if you completely inhibited 5α-reductase and nuked DHT, still provides better libido and erection quality than Nandrolone does at equivalent "therapeutic" doses for the majority of people.
My Blood Work Results On A Deca Only Cycle For HRTI don't like taking shots in the dark when it comes to something that I see potential in.
There is a lot of theory thrown back and forth in the community on Deca only cycles, and I needed to see for myself how Nandrolone in conjunction with exogenous Estradiol would impact my personal blood work.
I wanted to check markers of oxidative stress, inflammation, kidney function, Aldosterone, Prolactin, hormone levels via sensitive assay testing, and an array of other health markers that are often debated about but very infrequently actually tested for to reinforce statements made.
Expectedly, high dose Deca only cycle blasts will almost always result in low HDL levels, subpar Estradiol levels, and an array of other out of range values that are less common and are more individual dependent.
To date I have yet to see someone get their blood work checked with exogenous Estradiol being used in conjunction with Nandrolone at a "therapeutic" dose.
This is what I wanted to evaluate.
Complete Blood Count with Differential/PlateletsI was actually expecting far worse from my blood test results.
At a "therapeutic" dose, it doesn't seem like my hematology was negatively affected at all.
Comprehensive Metabolic PanelIn my metabolic panel, nothing was really off to the point that would cause concern.
My BUN being high is likely just the result of being muscular and having a high protein diet.
Lipid PanelGoing into the lipid panel, we can see the number one most common blood test result among steroid users.
My HDL is low.
LDL is also borderline high, but not overly concerning when I can see that my Triglycerides are pretty low.
The reason why my HDL was too low was that my Estrogen levels were too low.
Again, this just reinforces the fact that Nandrolone does not sufficiently aromatize into Estrogen.
I will get into my Estrogen level and why it was still too low even with Estrogel administration later once we get to that part of the blood test results, but my HDL could have been in range if my Estrogen level was in check.
If I didn't use the Estrogel my HDL likely would have been in the single digits.
I know I can get my HDL into the reference range if my estradiol levels were doubled, which I have the leeway to do.
Iron And Total Iron Binding CapacityGetting into Iron and TIBC we can see that everything looks pretty normal here.
Total Testosterone And Free TestosteroneExpectedly, by assessing my Total Testosterone level via liquid chromatography with tandem mass spectrometry (LC/MS-MS) and my Free Testosterone level via equilibrium ultrafiltration, we can see that my Testosterone levels were crashed.
Both the total and the free were lower than a healthy female.
This is what you should see in your blood work if you’re on just Nandrolone.
The only Testosterone being produced in my body was indirectly via the trace amounts of androgens produced in my adrenal cortex, which is why the value wasn't completely bottomed out at 0.
I've mentioned many times the importance of getting high sensitivity testing done for hormone levels and how Nandrolone will register as Testosterone in primitive garbage blood tests.
This is another great example of this.
In addition to high sensitivity testing, I had the same blood tested using electrochemiluminescence immunoassay (ECLIA) for my Total Testosterone level, and direct analog enzyme immunoassay (EIA) for my Free Testosterone level.
These were the test results using the exact same blood sample with the terrible default assays that doctors will use to determine how to treat you, and that labs will give you in the majority of your blood work panels.
According to ECLIA and EIA, I have a normal Total Testosterone and Free Testosterone level.
Hilarious.
This just one example of why getting accurate hormone testing is critical.
My Testosterone levels are actually in the gutter, but the stupid primitive tests that doctors and labs give out as defaults for people is so f*cking stupid that it can't even tell the difference between Testosterone and 19-nortestosterone in my blood.
Renin Activity and AldosteroneMy renin activity and Aldosterone appeared to be normal.
This is one of the main things I wanted to check because there's a lot of speculation around the effect Nandrolone is going to have on Aldosterone levels.
When it comes to the Deca only cycle, there's something going on that throws off homeostatic mechanisms that regulate blood pressure that does not appear to be Estrogen related or Aldosterone related.
At least based on my blood work, my Aldosterone was definitely not at a level that could imply any kind of negative effect on blood pressure.
My Aldosterone level was low if anything.
Granted, some markers in the serum can be relatively worthless when compared to actual tissue concentrations, but at least based on my blood work, Aldosterone does not appear to be the culprit.
The first thing many jump to when explaining blood pressure regulation is the effect Nandrolone supposedly has on spiking Aldosterone through the roof, but it just doesn't appear to be the case in my experience as you can see yourself here.
Vitamin B12 and FolateMy B12 and Folate levels were normal.
PregnenolonePregnenolone appeared to be normal and within the reference range for men which is notable, as many assume that Nandrolone will shut down the production of precursor steroids.
That does not appear to be the case either.
I assumed precursor hormone levels like Pregnenolone would be less affected than many seem to think as most circulating Pregnenolone is derived from the adrenal cortex.
Dihydrotestosterone (DHT)Expectedly, my DHT was very low.
This is because I have almost no Testosterone being produced to 5α-reduce into DHT.
If my Testosterone is low, my DHT will be low as well.
DHT Backdoor PathwayContrary to popular belief, there is a backdoor pathway via Pregnenolone that can create DHT as well, which contributes to the chunk of DHT I have in my blood.
Hemoglobin A1c appeared to be normal at 5.1%.
Thyroxine (T4)My Free T4 was 1.28 ng/dL, which is acceptable.
DHEA-SulfateMy DHEA was in range and actually on the high end of normal.
Being on exogenous Nandrolone or Testosterone does not shut down DHEA production.
CortisolCortisol was "normal" apparently, although it looks a bit high to me.
I believe this result was mostly sleep hygiene related rather than entirely Nandrolone related.
Thyroid Stimulating Hormone (TSH)My TSH is too high.
I've never had a TSH this high before.
I have had a TSH in the 2's before, this isn't the first time, but never this high.
However, based on my resting heart rate and my morning waking temperature and my mid-day temperature, my metabolic rate seems to be the same as it usually is on TRT, and I have had no standout hypothyroidism symptoms.
Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH)Expectedly, LH and FSH were undetectable.
ProlactinMy Prolactin was on the low end of normal.
This was another interesting health marker to see on Nandrolone, as many will often jump to assuming that Nandrolone spikes Prolactin levels through the roof.
That does not appear to be the case though.
Prostate-Apecific Antigen (PSA)My PSA level was normal, and did not change from my previous blood work on Testosterone for TRT.
D-DimerMy D-Dimer was normal.
A friend of mine had a very high D-Dimer level on a Deca only cycle and he wanted me to check mine to see if there was a pattern.
It looks like the elevated D-Dimer was case-specific for him and was probably caused by something completely unrelated, as my D-Dimer is normal.
C-Reactive ProteinC-Reactive Protein is one of the primary markers we have for assessing inflammation in the body.
A C-Reactive Protein level of 0.34 mg/L is not overly concerning, although I would like to see it below 0.3 mg/L.
I had undetectable C-Reactive Protein levels in the past on TRT, and on Nandrolone it jumped up to 0.34, which is notable.
Estradiol, SensitiveMy Estradiol (E2) level determined via LC/MS-MS was only 15.4 pg/mL, despite administering 2.5 grams of Estrogel per day.
This was disappointing, as I would have liked to see my E2 at least around 30 pg/mL based on the amount of Estrogel I was applying daily.
Evidently, my inner thigh was not absorbing the Estrogel very well.
This is one of the recommended areas of application, but my results were not even close to in line with the average blood levels found in the Estrogel pharmacokinetics studies.
With daily administration of 2.5 g or 5 g Estrogel (corresponding to 1.5 mg or 3 mg estradiol, respectively), mean serum estradiol concentrations of approximately 80 pg/ml (294 pmol/L) and 150 pg/ml (551 pmol/L), respectively, are maintained.
Administration of Estrogel also results in increased serum estrone concentrations, producing a physiological estradiol/estrone ratio of approximately one.
Therefore, serum concentrations of both estradiol and estrone and the serum estradiol/estrone ratio provided by ESTROGEL® are consistent with physiological levels observed during the follicular phase of the normal menstrual cycle.
My inner thigh isn't very hairy at all as I manscape fairly regularly, so I expected at least a 40 pg/mL E2 based on the amount of Estrogel I was applying.
I was overly generous with my dose based on the off chance that I would encounter an absorption issue, and my E2 was still way below where I expected it to be.
Based on the pharmacokinetics outlined by Merck, 80 pg/mL is the average E2 level for someone applying 2.5 grams of Estrogel per day.
There's no way I could have predicted that I would have an absorption issue so problematic that it would result in five times lower absorption than the average.
If my E2 was closer to 30 pg/mL, I expect that my HDL would have been pushed into the reference range, and all Estradiol driven physiologic functions likely would have been more optimized.
To me, this just reinforced further that Nandrolone is a subpar source of Estradiol as I was using a high dose of transdermal E2 and still could barely reach a satisfactory E2 level.
To increase my E2 levels for similar future experiments I will either have to find a better application area, add some DMSO to my Estrogel to increase absorption, or consider Estradiol injections instead.
HomocysteineMy Homocysteine level was higher than I would like.
Normally my Homocysteine is closer to 8-8.5 umol/L.
Earlier in the year when I did a shorter Nandrolone experiment for a month using 200 mg per week (double the dose I used for this experiment) I had a Homocysteine level around 8.5, so I doubt this spike was Nandrolone related.
This is one of the main markers I always have my eye on because I am homozygous for the C667T polymorphism.
Gamma-Glutamyl Transferase (GGT)My GGT looked good.
I was worried that this would be cranked through the roof as it is a marker of oxidative stress.
MagnesiumMy magnesium level looked okay.
Copper and ZincMy zinc level looked okay.
My copper level may be a bit low, which I am now addressing by eating an ounce of beef liver every day.
ProgesteroneMy Progesterone was normal, which is notable as it is another precursor hormone that many assume drops to zero when exogenous anabolic steroids are present in the body.
InsulinMy insulin level was good.
EstroneExpectedly, my Estrone was a bit high.
This can be a major problem with exogenous Estradiol and Nandrolone unfortunately.
Estrone Level Increase From Exogenous EstradiolThe ratio of Estrone-to-Estradiol is skewed with massive elevations in Estrone with oral Estrogen administration.
Fortunately, this unhealthy ratio can be avoided for the most part with transdermal Estradiol administration.
High levels of serum Estrone sulfate (E1S) were found after long-term oral estrogen treatment of commonly prescribed dosages, whereas there was a small increase in E1S levels after transdermal Estradiol (E2) therapy.
The mean maximum E1S levels were more than 20-fold higher with oral estradiol (E2) when compared with the 0.05 mg/day transdermal estradiol patch.
This is consistent with the 20-fold higher dose of E2 when compared with the transdermal dose [R].
Estrone Level Increase From NandroloneNandrolone also significantly elevates concentrations of Estrone in plasma [R].
During a pilot study evaluating the possible beneficial effect of Nandrolone Decanoate (ND) on bone metabolism in patients with rheumatoid arthritis there was a significant increase in the serum levels of Estrone [R].
Despite the fact that Estrone can convert to Estradiol, we can clearly see that the amount this actually happens in the body is minimal based on the consistently skewed ratios of androgens to Estradiol in the blood test results of Deca only users (or Nandrolone in general).
FerritinMy Ferritin level is too low.
This is likely the result of phlebotomizing too frequently in 2019.
EstriolMy Estriol level was undetectable, which was expected.
Triiodothyronine (T3)My Free T3 level was 2.7 pg/mL.
It's not low enough for me to be overly concerned, however, it is suboptimal and should be in the low 3's at least.
This is something I will need to address moving forward.
With that being said, I like to look at my resting heart rate as well as my body temperature for a more accurate assessment of my metabolism, and both are where I want them to be.
My waking temperature has consistently been 98 degrees Fahrenheit, and my midday temperature has consistently been 98.6 degrees Fahrenheit.
Sex Hormone-Binding GlobulinExpectedly, my sex hormone-binding globulin (SHBG) was low.
While this isn't as relevant for a Nandrolone only user as Nandrolone has a very low affinity for SHBG, this is a value I would still like to see in the reference range, especially if I was on TRT.
If I had the Estradiol level I was shooting for, I'm confident that my SHBG would have been in the reference range.
My Overall Experience On Nandrolone And Exogenous Estrogen For HRTI was expecting to see a bunch of red flags in my blood work, but nothing really stood out as a major concern to me except for the spike in systolic blood pressure, and the high Estrone level.
A before and after echocardiogram and calcium scoring would have been nice to see, but unfortunately I can only afford to do so much in these experiments, and the blood work was expensive enough as is.
I felt good throughout the entire experiment, I maintained my physique, my libido and penis were functional, and my blood work looked pretty good considering that each issue was something more so related to my Estradiol administration than the Nandrolone itself.
Estrone being out of range is a concern, as I would need to use even more exogenous Estradiol to achieve what I would consider a more therapeutic E2 level, which would likely push my Estrone up even higher.
The difficulty in controlling the blood pressure spike is also a huge concern and could be a deal breaker.
If I gave this experiment more time, it is entirely possible that certain things would have become problematic that appeared to be fine during my three month assessment, like my libido or sense of well-being.
It is also possible that despite maintaining a healthy Estrogen level, the same neurological and cardiovascular issues we see in a significant amount of the Nandrolone data could still accumulate over time.
In addition, healthy looking serum levels of Estradiol may not necessarily reflect adequate localized Estrogen receptor activation in each tissue.
With Testosterone, there is a regulated amount of aromatization occurring in each tissue to satisfy however much Estrogen receptor (ER) activation we need.
In the context of Deca only cycles, or Nandrolone monotherapy, there's nothing else I can refer to other than serum levels, my libido, sense of well-being, other cardiovascular health markers, etc.
In other words, just because you feel good and your Estrogen levels look good on paper, that doesn't mean that an exogenously administered source of Estrogen is providing the same therapeutic ER activation in all tissues like it would if it were regulated via aromatase.
With that being said, you could also argue the opposite as adequate receptor activation via exogenous hormone therapy is essentially all HRT boils down to to begin with in the context of any hormone.
More than 95% of our endogenous Testosterone is produced in the testes.
Testosterone is supplied to target tissues in the blood, just like most other hormones in the body.
If you inject exogenous Testosterone, it then goes into the blood and is supplied to target tissues.
If you inject anything it goes into the blood and then is carried to the areas that it is needed.
Estrogen replacement has been deemed satisfactory for fulfilling the same functions as endogenously produced Estrogen in women for years, and synthetic Estrogen analogs are handed out like candy to millions of young girls (including teenagers).
Is it healthy?
Estrogen analogs like Ethinyl Estradiol probably aren't ideal for regulating Estrogen dependent functions, and they definitely aren't ideal for developing women who haven't fully matured.
However, there is tons of data to support the fact that exogenous Estradiol is well-tolerated, has a strong safety profile, and can still fulfill physiologic functions sufficiently.
In an ideal world, this would be a regulated process in the body in each tissue (aromatization).
My experiments do not necessarily reflect what I believe are best practice with these hormones, which should be noted.
This was an experiment, and not something that I would recommend someone else do.
Using an exogenous progestogen with estrogel certainly isn't what I would consider an optimal HRT protocol, or what is indicative of an ideal means of providing androgenic and estrogenic support in tissues.
With that being said, I don't see a better way to go about utilizing Nandrolone on its own for HRT.
Should it even be considered as an HRT alternative though?
That's the question, and I believe it is largely going to be individual dependent, with a significant amount of users having poor outcomes in one aspect or another.
I do believe there are a minority of individuals who are very prone to androgenic and/or estrogenic side effects from exogenous Testosterone use that may benefit from exploring Nandrolone though, and it should not be discarded as a potentially viable alternative simply because it is not the primary bioidentical hormone that men produce.
Testosterone is not neuroprotective, estrogen is.
A common myth circulating in the bodybuilding and TRT community is that testosterone is inherently neuroprotective and is unique from all other anabolic steroids in that regard.
The reason why testosterone is neuroprotective is simply because it aromatizes at a rate that provides a sufficient amount of estradiol to balance out the androgenicity in the body.
Data in rodent models using cortical cells suggests this very convincingly by showing how the aromatase inhibitor Anastrozole (Arimidex) completely eliminated the neuroprotective effects of testosterone [R].
https://youtu.be/Gv_v0mJy6Bg
Are Synthetic Anabolic Steroids More Dangerous Than Testosterone?There have been tons of studies published suggesting how much worse synthetic anabolic steroids are in contrast to testosterone for cardiovascular disease, neurotoxicity, and a myriad of other deleterious outcomes.
I believe that a significant amount of this data is exaggerated based on the fact that exogenous estrogen is never co-administered in these studies.
At the end of the day, testosterone is the safest androgen at physiologic dosages.
However, I theorize that many synthetic anabolic steroids are not as dangerous as we are led to believe.
My theory is that some compounds are not inherently significantly more dangerous than testosterone, rather, it is their lack of aromatization, 5-alpha reduction, or differing affinity for off-target receptors that makes them more dangerous.
The effect on estrogen receptors and how potent of a substrate an anabolic steroid is for aromatase is the main factor that impacts how viable a hormone is for consideration in a monotherapy context.
DHT derivatives cannot be converted by the enzyme aromatase into an estrogen like estradiol.
Nandrolone (19-nortestosterone) and its derivatives (19-nors) each have their own individual affinity (or lack thereof) for estrogen receptors and interaction with aromatase, often resulting in subpar estrogen levels (exceptions to this exist such as Trestolone/MENT).
Basically, I believe that some steroids may show to be significantly more cardiotoxic and neurotoxic in the data because they are always used on their own with an insufficient amount of estrogen to balance out the androgenicity in the body.
The Importance Of Sufficient Estrogen LevelsHealthy estrogen levels are needed for libido, erection quality, vasodilation, cardiovascular health, brain health, bone health and several other critical functions.
In women the risk of cardiovascular disease spikes significantly after menopause.
It isn't a coincidence that the majority of women who develop heart disease have it occur after their estrogen production has dropped to sub-male levels.
If you don't have a sufficient amount of estrogen relative to androgen levels in the body, cardiotoxicity and neurotoxicity levels will be significantly higher than they would be if healthy estrogen levels were sustained.
From a bodybuilding perspective, estrogen is needed to optimize muscle growth, fat loss, as well as IGF-1 and growth factor production/cellular signaling.
This is why heavily aromatizing steroids may indirectly result in greater growth potential and are often classified as "bulking" compounds.
Anecdotally, many bodybuilders report that the most they've ever grown was during off-season mass building phases when their estrogen levels were through the roof.
The Point Of A Testosterone BaseTestosterone is not tissue selective and is actually a poor muscle builder milligram for milligram when compared to other synthetic anabolic steroids developed in the years following its discovery.
When it comes to nitrogen retention, on paper it is not superior to many anabolic steroids.
However, it aromatizes into estradiol at a very tightly regulated rate, it is bioidentical, and our body knows exactly what to do with it.
In addition, our body knows how much testosterone to bind up with SHBG, how much to free up and make available to tissues, as well as how much DHT to 5-alpha reduce to antagonize estrogen receptor activation should it get out of control.
From a bodybuilding perspective, testosterone is subpar in many aspects.
However, in an overall health, longevity AND bodybuilding context, testosterone cannot be beat at therapeutic dosages.
By using a testosterone base or a source of sufficient estrogen the shortcomings of other anabolic agents can be attenuated to some extent, hence why testosterone is the base of most steroid cycles.
The Balancing Act Of Testosterone, DHT and EstrogenSteroidogenesis in the body is carried out like a massive orchestra to regulate countless functions.
It's far more elaborate than simply testosterone, estrogen and DHT production.
Even at a snapshot view, the balancing act of androgens and estrogens in the body is tightly regulated and is carried out to ensure health remains optimized.
This balancing act gets more and more dysfunctional with age, poor lifestyle, poor diet, poor sleep hygiene and numerous other factors.
However, the body still knows exactly what to do with testosterone, how to create an optimal opposing amount of estrogens, and how much testosterone to 5-alpha reduce into DHT to oppose excessive estrogens and support male secondary sex characteristics.
When you compare clinical data on a synthetic anabolic steroid to testosterone in a monotherapy context, you have to consider that these studies are utilizing that synthetic steroid on their own, not with exogenous estrogen or any supplementary hormones that may be needed to balance out its androgenicity, lack of estrogenic activity and/or interaction with aromatase.
Obviously if you take a compound that doesn't aromatize sufficiently to estrogen and compare it head to head with the bioidentical androgen that our body knows how to aromatize and 5-alpha reduce at a perfectly balanced rate, you can just imagine which is going to come out on top in a cardiotoxicity and neurotoxicity context.
Does this mean that a synthetic anabolic steroid compared to testosterone would not potentially be more efficacious than testosterone should those other backend pathways be supplemented to fill the gaps though?
Synthetic Anabolic Steroids With Exogenous Estradiol For HRTSome individuals have underlying genetic polymorphisms and defects in sex hormone metabolism that may throw off the tightly regulated steroidogenesis pathway in a way that skews too heavily in favor of estrogen, or too heavily in favor of androgens.
There are many cases in which synthetic anabolic steroids may beat out testosterone, despite testosterone on paper being the candidate of choice for most men at therapeutic dosages, and still the candidate of choice for many men at supraphysiological dosages too in a bodybuilding context.
Nandrolone is a great compound to exemplify this in my opinion.
It has a much lower level of androgenicity in the body due to its 5-alpha reduction into DHN, and it is also far less estrogenic than testosterone.
Those who are prone to gyno, hair loss, acne or other common testosterone related side effects typically prefer nandrolone for this reason.
This is why many female oral contraceptives are nandrolone analogs as well.
Unfortunately, your heart and brain don't care if you have hair loss, acne, or gyno, so there can be deleterious outcomes as a result of androgen use without a sufficient amount of unopposed estrogens, or an estrogen excess without sufficient androgen opposition.
In regards to nandrolone, I don't believe it has a sufficient amount of opposing estrogen to balance out its androgenicity.
It activates estrogen receptor alpha (ERα) a bit via its inherent estrogenicity and it can aromatize to estrone, which can then convert to estradiol, but the amount of overall estrogenic activity it provides does not appear to be sufficient to offset its neurotoxicity or cardiotoxicity.
I believe this is why most of the data found in nandrolone studies shows how horrible it is for the brain and the heart.
Nandrolone is always evaluated on its own without a sufficient amount of estrogen present to provide cardiovascular and neurological support.
If you shut down your natural endogenous testosterone production with an exogenous steroid, you will also shut down your natural endogenous estrogen production.
Any estrogen production (or lack thereof) would then be derived from whatever exogenous steroids are being administered.
This is why some synthetic steroids may not necessarily be as dangerous as we once thought, as the data we use to review their safety profiles are skewed by their lack of estrogenic support in the tissues that would otherwise be supported by testosterone aromatizing into estradiol.
In the presence of sufficient estrogen, it is entirely possible that the deleterious effects of certain synthetic steroids in the body may be attenuated to some extent.
The Neurotoxicity Of Testosterone, Nandrolone And WinstrolComparing the effect of testosterone with that of 19-nortestosterone (nandrolone) and stanozolol (Winstrol) on neurotoxicity we can clearly see that estrogen is what protects neurons in the brain, not testosterone itself.
In this study, a physiologic dosage of testosterone was neuroprotective [R].
Testosterone only amplified neurotoxicity at supraphysiological dosages.
The neuroprotective effect of a physiologic dosage of testosterone was completely eliminated when the aromatase inhibitor anastrozole (Arimidex) was co-administered, suggesting that the intrinsic toxicity of testosterone as an androgen is only counterbalanced by its aromatization into 17β-estradiol.
As opposed to testosterone, nandrolone does not appear to aromatize sufficiently into estrogen, and Winstrol does not interact with aromatase at all.
As you would expect, nandrolone and Winstrol were both neurotoxic at every single dose evaluated regardless of Arimidex being co-administered or not.
The anti-androgen flutamide was able to attenuate the neurotoxicity of all three androgens, thus further reinforcing that physiologic dosages of androgens without a sufficient amount of opposing estrogens, or supraphysiological dosages of androgens may facilitate neuronal death.
None of the anabolic androgenic steroids in this study were toxic in the absence of NMDA, therefore suggesting that the mechanism by which unopposed androgens facilitate neuronal death is by increased vulnerability to excitotoxic insults.
Testosterone Neuroprotective Effect Of Testosterone At Physiologic Dosages Without ArimidexAt physiologic dosages without an aromatase inhibitor present, testosterone has shown to have a neuroprotective effect.
It is often assumed that the androgen itself (testosterone) is what protects the brain.
However, the aromatase inhibitor Arimidex completely eliminated all neuroprotective effects of testosterone at that same physiologic dosage.
Arimidex (anastrozole) exacerbated neurotoxicity at every single testosterone dosage when it was co-administered.
This suggests that testosterone is not a unique androgen that is more neuroprotective than all other steroids, rather, it is its aromatization into estrogen that is neuroprotective.
Neurotoxicity Of Testosterone At Suraphysiological Dosages With And Without ArimidexAt supraphysiological dosages, testosterone has shown to exacerbate neurotoxicity.
While its aromatization into estrogen still prevents a significant amount of neuronal death, we can clearly see that supraphysiological testosterone concentrations exacerbate neurotoxicity regardless, and supraphysiological estrogen levels will not provide dose-dependent increases in neuroprotection.
What is the takeaway from this?
The data suggests that physiologic concentrations of testosterone facilitate neuroprotection in the brain via aromatization into estrogen, but there is a threshold to that neuroprotection, and supraphysiological concentrations will still be unhealthy.
Nandrolone (19-nortestosterone) Neurotoxicity Of Nandrolone Regardless Of Arimidex UseNandrolone exacerbated neurotoxicity at all dosages, regardless if it was a low concentration or a high concentration being evaluated.
In addition, co-administering Arimidex had no impact on how neurotoxic nandrolone was in this model at any dosage.
This suggests that nandrolone does not aromatize into a sufficient amount of estrogen, or activate estrogen receptors on its own at an amount satisfactory to provide the neuroprotective effects of healthy estrogen levels.
A source of estrogen would likely be necessary to co-administer with nandrolone for it to be considered a viable monotherapy alternative in a HRT context, or as a "healthy" cycle.
Winstrol (Stanozolol) Neurotoxicity Of Winstrol Regardless Of Arimidex UseWinstrol exacerbated neurotoxicity at all dosages, regardless if it was a low concentration or a high concentration being evaluated.
In addition, co-administering Arimidex had no impact on how neurotoxic Winstrol was in this model at any dosage.
We already know that Winstrol does not aromatize into estrogen at all.
This data suggests that a source of estrogen would be necessary to co-administer with Winstrol for it to even be considered as a viable monotherapy alternative in a HRT context, or as a "healthy" cycle.
Unopposed androgens with an insufficient amount of estrogen present will be cardiotoxic and neurotoxic.
This is why Flutamide (an anti-androgen) was able to eliminate the neurotoxicity of nandrolone and Winstrol.
Anti-androgens have a dose-dependent response just like anabolic androgenic steroids, so there will be androgen receptor (AR) competition occurring between anti-androgens and androgens for AR binding and activation.
Anti-androgens will act as competitive antagonists for AR, or as makeshift synthetic steroids themselves, albeit with significantly reduced androgenicity.
Basically, depending on the anti-androgen used, they will work either by suppressing endogenous androgen production, and/or by competing for androgen receptors.
How effective the anti-androgen will be at inhibiting androgens from binding to AR will be based on binding affinity, binding constant, half-life, the dosage used, and a myriad of other factors.
Flutamide is non-steroidal and acts as a selective, competitive, silent antagonist of the AR.
It is a primitive and subpar anti-androgen relative to more recent developments in medicine, however, it is still effective at preventing androgens from binding to androgen receptors.
This is why flutamide was able to eliminate all of the neurotoxicity of nandrolone and Winstrol at all dosages.
By preventing nandrolone and Winstrol from binding to androgen receptors, they are no longer able to transcribe their effects in tissues.
The flutamide and Arimidex data reinforces the fact that nandrolone does not produce enough estrogen to provide the neuroprotection needed to stave off neuronal death.
With or without an aromatase inhibitor, nandrolone exacerbates neurotoxicity just the same.
Without an aromatase inhibitor but with an anti-androgen, the neurotoxicity of Nandrolone is eliminated entirely.
I suspect that the same applies for the inherent cardiotoxicity of nandrolone as well.
Expectedly, the same applies for Winstrol as it is not a substrate for aromatase at all.
This is where all the studies showing how terrible nandrolone is for the heart and brain come into question, as those negative outcomes found in the data may not have been so drastic if an exogenous source of estrogen was co-administered.
The same dosage of flutamide was unable to fully offset the neurotoxicity of testosterone at supraphysiological dosages without Arimidex present.
Once testosterone dosages exceed physiologic concentrations, the vulnerability to neurotoxicity and cardiotoxicity skyrockets.
Too much of anything in the body is going to be bad, and testosterone is not exempt from this just because its the bioidentical hormone we naturally produce and aromatize into estrogen.
The Aromatization Of Androgens Into Estrogen Is What Regulates NeurotoxicityReflecting on the data with and without an aromatase inhibitor we can see quite clearly that estrogen is what facilitates neuroprotection, not testosterone.
Many assume that testosterone is a unique androgen that binds to AR in some special way that's going to protect the brain and other steroids are going to destroy the brain.
I don't think it's as cut and dry as that.
I think it's pretty clear in the data that with anastrozole co-administered the neuroprotective effect is wiped out, and without anastrozole there is a neuroprotective effect.
What is the difference between aromatase being inhibited and aromatase not being inhibited?
It is the estrogen level in the body.
If you have a sufficient amount of estrogen to balance out androgens in the body, you get a good stable level of neuroprotection, which is reflected in how our body regulates endogenous androgen aromatization as is.
But, if you have a supraphysiological level of androgens, or inhibit aromatase from providing the estrogen needed to carry out necessary functions in the body, neurotoxicity spikes up regardless of the fact that it is testosterone being evaluated, not a non-bioidentical synthetic anabolic steroid.
This all circles back to the rationale behind using a testosterone base on cycle, or having a sufficient source of exogenous estrogen if you are deficient.
It also reinforces that aromatase inhibitors are horrible for you if used unnecessarily.
My Stance On Aromatase InhibitorsYou would be well served by doing whatever you can to avoid using aromatase inhibitors.
If you even need an aromatase inhibitor in the first place you're likely either using too much testosterone to begin with (or other aromatizing steroids), you're too fat (more fat = more aromatase), your diet sucks, your lifestyle choices are poor, or you're injecting too infrequently.
Or you might have a genetic polymorphism that results in subpar sex hormone metabolism.
At the end of the day, the likelihood that you would need an AI to handle a truly therapeutic dose of testosterone if you've optimized everything is extremely low.
In a bodybuilding context at supraphysiological dosages, I also think that in most cases using an AI just so you can use "too high" of a testosterone dose is a poor strategy.
Should You Take Exogenous Estrogen To Prevent Neurotoxicity And CardiotoxicityJust because estrogen is what provides neuroprotection, not testosterone, it absolutely does not mean that you should start popping your girlfriend's birth control pills like candy.
Unopposed estrogen in the body is carcinogenic.
There is a reason why the first go to treatments for breast cancer are SERMs and aromatase inhibitors.
Also, estrogen does not provide neuroprotection in a dose dependent manner.
There is a sweet spot for everything in the body, and too much of anything is going to be bad.
A 4-day pretreatment with low concentrations 0.01 μM (10 nM) of 17β-estradiol was substantially neuroprotective against NMDA toxicity.
However, you can clearly see that there was not a dose dependent decrease in neurotoxicity in this study.
Neuroprotection was significantly lower with 1 μM 17β-estradiol than with the much lower dosage of 0.01 μM 17β-estradiol.
More is not better with anything in the body.
The body has a tightly regulated system in place whereby a certain amount of estrogen is needed for physiologic functions.
Too much estrogen without enough androgens can result in cancer development, gynecomastia (gyno), and a myriad of other issues.
Too little estrogen and excessive androgens can result in cardiovascular disease, neuronal death, and a myriad of other issues.
So, if you are using an androgen without a sufficient amount of opposing estrogen to balance it out, you will not only be inhibiting muscle growth and fat loss, but you will be putting your body in an even more quickly deteriorating state of health than you would have already been in regardless simply as a result of supraphysiological androgen levels.
If you are using a TRT dose of testosterone, you would be best served by not unnecessarily inhibiting aromatase.
Also, if you are using an anabolic steroid that is not a potent substrate for aromatase, you would be best served by adding a testosterone base or a source of adequate estrogen to your cycle.
The interesting thing to evaluate would be whether all of the anabolic steroids previously described by the literature as horrendous for the heart and brain would still be described as such if an adequate dosage of exogenous estrogen was used in conjunction with them in the corresponding studies.
It certainly opens the mind up to potential hormone replacement therapy alternatives, hence my experimentation in the past with Trestolone monotherapy, low dose Nandrolone with exogenous estradiol, and SARMs with exogenous estradiol.
Kevin Levrone is among professional bodybuilders like Dorian Yates who have opened up about their steroid cycles and dosages.
In an interview with Muscular Development Kevin Levrone outlined his first and second steroid cycles with specific details, which gives us great insight into what kind of compounds and dosages he used to build his physique up.…
As more and more IFBB pros and past Mr. Olympia winners like Dorian Yates start to open up over social media about their steroid use, we have started to get incredibly detailed insight into things like their genetic response to their first steroid cycle.…
After reviewing the molecular weight of some of the most promising SARMs developed, I theorized that they could potentially be prepared in a topical solution for hair loss prevention.
As you probably already know, Selective Androgen Receptor Modulators (SARMs) are a class of androgen receptor ligands that bind to androgen receptors and exert tissue selective anabolic effects with a relative lack of androgenicity when compared to traditional anabolic steroids.…
There's a misconception that Finasteride is a reliable source of remedy for hair loss prevention caused by the intake of all anabolic steroids.
For anyone who has reviewed the downstream mechanisms of Finasteride in the body, it is clear that this is not true.…
It’s theorized in the bodybuilding community that the reason Flex Wheeler and other top Olympia caliber bodybuilders are able to build such incredible physiques is due to Myostatin deficiency.
Other popular theories circulate around that include ideas as vastly different as androgen receptor sensitivity is higher in top bodybuilders, to the complete opposite side of the spectrum where some believe that training past a certain pain threshold is what separates champions from the rest and that genetics are just a small factor in determining bodybuilding success.…
Many health authorities state that natural Testosterone levels decrease by 1% per year.
This figure is incorrect, and is not based on bioavailable Testosterone.
Once men enter their 30's and start to get closer to being middle-aged, their endogenous Testosterone production starts to steadily decline.…
One of the most common obstacles guys run into during a cutting phase is plateauing in fat loss when they are eating less than 2000 calories per day, which is what I consider to be an unsustainable amount of calories for the majority of men.…
There is a lot of speculation around whether or not Chris Hemsworth's transformation for Thor was natural, or if he did a steroid cycle during his prep for the film in 2009.
Chris Hemsworth purportedly gained between 20-25 pounds of muscle in 6 months to prepare for his role of Thor [R].…
After clinical data started circulating in the bodybuilding community showing that Trenbolone administration caused beta amyloid plaque accumulation in rat brains, more and more attention has been given to the potential neurodegenerative effects it may have in humans, and how Trenbolone may cause the progression of Alzheimer's disease.…
When I first started getting into bodybuilding and learning about pharmacology, a strategy I would see commonly advised on forums and by industry gurus was switching compounds at week 6 or week 8 to avoid androgen receptor downregulation and circumvent a plateau on a steroid cycle.…
I've been asked a few times about topical Estrogen cream for hair loss prevention.
BiEstro-Care cream and Estrogel in particular.
BiEstro-Care is a is a combination of 1 mg of natural Estriol USP and 0.25 mg of natural Estradiol USP per pump.…
Never do a quad injection.
There are other shot locations that are far better and I'm going to elaborate on why in this article.
When you first get into this stuff and you're trying to learn about proper administration technique the main shot locations you'll see recommended are glutes, quads, and maybe delts.…
It is theorized in the community that MK-677 can cause brain damage via chronically elevating ghrelin levels in the body.
Does this crossover to human use, and has it been observed to date?
Well, there have in fact been links established between chronic ghrelin exposure and negative mental outcomes.…
Lactobacillus Reuteri ATCC PTA 6475 is a strain that was hyped up in the community after an article was published called “Probiotic ‘glow of health': it's more than skin deep” [R].
In the article, you can see that the mice that were fed with this probiotic strain experienced significantly better hair growth, and also exhibited a much more favorable ratio of anagen to telogen hair cycle stages.…
After I made my first oral castor oil for hair loss post a couple of months ago, I received hundreds of DM's, private messages, YouTube comments, emails and tweets asking me to post an update.
Well, here it is.
After trying oral castor oil for hair loss for 2 months, I have concluded that it is an effective growth promoter, and is far more potent than topical castor oil.…
Gorilla Mode Pre-Workout is the most potent and comprehensive pre-workout on the market in ALL aspects.
Pump, strength, endurance, cognitive enhancement, and overall performance.
Gorilla Mode Supplement FactsPer Full Daily Dose:
Despite the fact that muscle bellies will mostly determine what shape your shoulders (or any muscle group) take on as they get bigger, there are some things you can do to maximize your genetics and encourage the development of capped 3D delts.…
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I finally got around to trying CB-03-01.
I had heard varying opinions on its therapeutic promise in the community, but at the end of the day I had to do a CB-03-01 review myself to see if this compound is superior to other alternatives we already have at our disposal.…
Chris and I met up in Vegas recently and filmed a few videos.
In this one, Chris and I go into the depths of the bodybuilding.com forums to find his first prohormone cycle log he made when he was 20 years old (almost 20 years ago when he was heavily into bodybuilding).…
Fouad Abiad recently had Mike from “The Research Station” on his podcast to discuss bodybuilding pharmacology.
While I agree with many of the concepts Mike presented, there are a handful which I felt were incorrect and should be addressed.
In general, there are two camps of individuals who have polar opposite views on the promise of SARMs.
One camp views them as weak alternatives to Steroids with just as many side effects.
The other camp hypes SARMs up as compounds that are nearly as effective (or just as effective) as Steroids, but with far less severe side effects.…
This article will detail a quick and easy way to determine whether or not you are experiencing male pattern baldness or telogen effluvium (temporary shedding).
If you've seen my other posts discussing hair loss, you probably already know that there is a difference between follicular miniaturization triggered by androgens, and shedding triggered by nutritional deficiencies, hormonal fluctuations, environmental factors, toxins, allergens, hypothyroidism, radiation therapy, and other stressors.…
There are a handful of strategies that can be implemented to get more vascular via significantly increasing nitric oxide, vasodilation, blood flow and muscle detail.
How do you get your bicep vein to really pop?
How do you force your veins against the surface of the skin and get that paper-thin skin look?…
Instead of taking an arbitrary amount of T3 and T4, it would be wise to address potential dietary deficiencies and autoimmune triggers first and foremost.
However, if exogenous T3 and T4 use is something you are dead set on, or you already use one or the other, you would benefit from knowing what healthy endogenous production actually equates to.…
I recently lowered my weekly TRT dose down to 100 mg Testosterone Propionate split into every day subcutaneous administrations with an insulin pin.
Micro-dosing every day results in the most stable blood serum concentrations possible, less aromatization, and more free testosterone.…
Julian Smith claims he bulked for six years straight.
He attributes the majority of his success/his accrual of lean muscle mass to this extended bulk phase he did that lasted six years.
Basically, he walked around fatter than he needed to be for six years with the logic that he needed to be in a surplus for over a half a decade straight and walk around at 20%+ to maximize his bodybuilding progress.…
I believe that interpreting blood work correctly and implementing an appropriate lifestyle and/or pharmacological protocol can reverse Post Finasteride Syndrome.
Post Finasteride Syndrome describes negative side effects caused by Finasteride that persist long-term, even after discontinuing its use.
Finasteride-induced side effects can be very real.…
Using mouth tape for Mewing has started to pick up in popularity as many are starting to learn about the potential ramifications that mouth breathing can have cosmetically, and on overall health.
It's one thing to consciously force yourself to Mew while you're awake, but Mewing while you are sleeping can be nearly impossible if you are not forcing yourself to breathe through your nose.…
Are you Mewing correctly?
While I've watched dozens of instructional videos and read through several articles to make sure I'm not wasting my time with what I thought was the correct way, I wanted to get my ear nose and throat specialist's input to see if it lines up with everything I've learned to date.…
My conversation with my ear nose and throat (ENT) specialist continued where we subsequently talked about the potential ramifications mouth-breathing can have on the craniofacial development, and its potential implications relating to my sleep apnea.
About a year ago, I started to dive down the rabbit hole of mouth breathing vs nasal breathing with “proper” tongue posture.…
Is turbinate reduction or deviated septum surgery for mewing effective?
In a previous discussion we have talked about whether or not my deviated septum or inflamed turbinates is the cause of my mouth breathing.
My ear nose and throat (ENT) doctor outlined how septal deviation and inflammation of turbinates compounds inhibition of nasal circulation.…
Following up on my previous post where I talked about my deviated septum, this topic extends by finding an answer to the cause of my mouth breathing.
During my last meeting with my ear nose and throat doctor I asked if the main cause of my mouth breathing was my deviated septum, or the inflammation of my turbinates.…
I used to be religious about hitting 5-6 workouts per week to maintain my physique.
This was at a time when I was hardcore into bodybuilding and assumed that any less than that would cause my physique to whither away.
This was also the same time that I assumed that I needed 200 mg per week of Testosterone for my TRT or else I would lose everything I had gained over the years.…
Oral castor oil is something not thoroughly explored in the hair loss community, despite a significant amount of promising data backing its potential efficacy.
Typically, castor oil is topically applied.
In practical application, its effect on hair loss prevention topically seems to be minimal when it comes to dealing with androgenic alopecia as opposed to a skin condition.…
Many bodybuilders seeking hyperplasia and enhanced lipolysis use GH (HGH/human growth hormone).
Even individuals just seeking anti-aging benefits have started to incorporate GH into their hormone replacement therapy protocols.
Most of these individuals have no idea what their IGF-1 levels actually are as a result of the amount of GH they are using.…
Are SARMs side effect free?
Also known as the Selective Androgen Receptor Modulators, SARMs are tissue selective anabolic agents designed with the intention of replicating the anabolic effects of steroids in muscle tissue and bone without the androgenicity in other affected tissues.…
Something every aspiring bodybuilder wants to know is what drugs and dosages the top IFBB pros at the Olympia are using.
This article is going to quickly break down the biggest steroid cycles used by 7 top tier IFBB pros in the 90s.…
0:00:00 – 0:02:48 Derek and Chris (Good Looking Loser) Discuss Why Most Nootropic Supplements Are Severely Underdosed
The owner of Regenepure personally reached out to me recently and expressed his gratitude for my posts I've made in the past where I spoke highly of their Ketoconazole shampoo.
To this day, Regenepure DR is still the first thing I tell people to use if they're starting a hair loss prevention regimen because it's over-the-counter, the risk profile is very low, and there's an extremely low incidence of side effects.…
This interview discussing Dennis Newman's steroid cycle was recorded by Tom Platz in the 90's.
There is some speculation as to whether this was Mike Matarazzo or Dennis Newman in the interview.
Some even thought it was Bob Ciccarello.
The consensus is that this is more than likely Dennis Newman, but we don't know for certain as this interview was meant to be anonymous after all.…
This is something I skimmed over in my initial article on Cardarine.
I wanted write a dedicated article on this topic as I believe the human equivalent Cardarine dose that caused cancer growth is often calculated incorrectly.
Many people think the dosage is some exorbitant amount and they use that to justify their use thinking the human equivalent dosage that caused cancer in rats was thousands of milligrams, when in reality, it really wasn't.…
This interview discussing Paul Dillet's steroid cycle was recorded by Tom Platz in the 90's.
This interview conducted with Tom Platz was intended to remain anonymous.
But, the internet is the internet, and people can figure out pretty easily with deciphering the 90's technology of looking at these blurred faces and listening to the noise distortion to make an educated guess about who it is.…
This interview discussing Lee Priest's steroid cycle was recorded by Tom Platz in the 90's.
This will give an inside look into what top pros with top 0.0001% genetics were doing in the 90's to achieve their physiques.
Obviously he could be lying, but I don't see any reason for him to lie, other than to downplay how much of an abuser he could come across as.…
Something that isn't common knowledge is that Nandrolone is recognized as Testosterone in standard assays used in the vast majority of blood tests.
Typically, this goes completely unnoticed because steroid users only check their Testosterone and Estrogen levels in their blood work, and 99% of those who actually use Nandrolone, use it concurrently with Testosterone as a base.…
When it comes to PEDs, the data we derive our conclusions from would ideally come from testing at the clinical level, as opposed to just anecdotes pulled off forums and bro-logs.
I found the following study really interesting because to date, no other study has reported findings using a higher steroid dosage.…
I've already written about if Finasteride lowers Testosterone levels.
I felt an article on Dutasteride was justified as well.
If you read the Finasteride article, you already know that Finasteride does not lower Testosterone, which is a common misconception.
It actually increases Testosterone levels, as does Dutasteride.…
One of my buddies online Steven, sent me a pamphlet for a European Sustanon prescription.
The most baffling thing about this pamphlet is the advised injection frequency at which this Sustanon is prescribed in Europe.
I do consultations over Skype through MorePlatesMoreDates.com,…
If I could go back in time, could I have achieved my current physique with only TRT dosages?
This will depend on a few factors.
It's becoming more and more common to see bodybuilders who are transitioning to a more health-conscious approach talk about how they can maintain their physique on very low dosages.…
“Should you use an oral steroid during your bulk cycle” has been a commonly asked question in the bodybuilding community.
It's not a yes or no answer.
With that being said, the entire point of this post is to delve into the very common scenario I see guys put themselves in where they actually limit their progress by using additional drugs.…
A lot of you guys have asked me if you can maintain Minoxidil grown hair after you've stopped using Minoxidil.
Can you maintain it with Finasteride, or another hair loss prevention treatment?
The harsh reality is that the hairs that you grow via Minoxidil use are 100% dependent on the Minoxidil.…
No, growth hormone (GH) cannot cause permanent hair loss.
However, it can cause temporary shedding.
Let's clarify the difference between androgenic alopecia and temporary shedding.
Androgenic alopecia, or male pattern baldness, is the acceleration of hair follicle miniaturization facilitated via androgen receptor activation, which is what most guys experience throughout their lives.…
Trenbolone (commonly referred to as simply “Tren”) is an anabolic androgenic steroid (AAS) that was popularized in the 90's, and has become an increasingly abused drug over the years.
Over the years, Trenbolone has evolved into such a commonly used hormone that it is seen by many as “tried and true,” and a necessity to build an amazing physique.…
This story is something I stumbled across by accident.
It's really interesting as it backs up the theory of wounding, and also implies the importance of Prostaglandins and the recruitment of growth factors via a stimulus.
In this story, a 78-year-old man with common male pattern baldness was dozing off in his armchair when he fell head first into a coal fire.…
This is also applicable if you moved to a new area and literally don't know anybody, which can feel very overwhelming.
A quick disclaimer before we being, it should also go without saying that online dating is a no-brainer to supplement your cold approaching with, but this article is going to address cold approaching specifically.…
2,4-Dinitrophenol, also called DNP, is a chemical uncoupling agent that inhibits the production of ATP in cells with mitochondria.
Via uncoupling oxidative phosphorylation, DNP raises body temperature in a dose dependent manner.
DNP use is the most frowned upon practice in the bodybuilding world aside from Synthol in my opinion.…
Most of you guys know I use a high-normal dose of TRT.
I try to keep myself right on the cusp of supraphysiological Testosterone levels.
In the past I've blasted with supraphysiological amounts numerous times, and the first steroid cycle in particular is what I want to delve into today.…
I always get asked how to get blood work in Canada.
In Canada it's not so simple, as you have to go to your doctor and they have to prescribe you the tests you want.…
0:00 – 2:16 Chris (Good Looking Loser) Introduces His Dog Charlie For The First Time
I'm constantly asked exactly how much muscle you can expect to gain from high dose testosterone, or a myriad of other performance enhancing hormones.
“If I take X amount of testosterone, how many pounds will I gain?”…
The standard hormone profiles by default include the cheaper FDA-approved Roche ECLIA (Electrochemiluminescence Immunoassay) methodology.
That test is wildly inaccurate in men, unfortunately.
Most men get by default when they get blood work done, and consequently receive an inaccurate result.…
The first thing you need to know before you start using Minoxidil is that Minoxidil does not prevent hair loss.
Typically, when a man starts noticing male pattern baldness, he may go to his doctor and say, “I'm losing my hair, what do I do?”…
Stan Efferding's Vertical Diet fills both macro and micronutrient needs, which are otherwise left unmet by standard, traditional bodybuilding diet models.
I started Stan Efferding's vertical diet mid-2018.
These were my goals:
Main Goals During The Vertical Diet:I've been asked to cover Brandon Harding's steroid cycle that he used in his last competition.
I found this video interesting because Brandon Harding is in the mainstream fitness industry niche.
He has a big channel and a big following, and he's probably the biggest in the mainstream to really break down what he's doing dose by dose, compound by compound.…
There's a lot of buzz on Gregory O'Gallagher, or Kinobody's Natty Verified Challenge, where he's basically going to grant official “Natty Verified” status to those who pass a carbon isotope ratio test to detect exogenous androgens in their system.…
When you first start working out as a newbie you'll notice after 24 to 48 hours you are absurdly sore.
When a new type of stimulus/resistance is exerted upon your body you will inevitably experience “delayed onset muscle soreness” (DOMS), which is completely normal and expected.…
I'm going to briefly break down why I think SARMs are a bad idea if you have low natural testosterone levels.
I often get asked by bodybuilders in their 40's to 50's who are looking into SARM experimentation what my recommendations are.…
Natural bodybuilding vs. enhanced bodybuilding while cutting yield significantly different outcomes.
Even just TRT is not the equivalent of being a natural, even if your Testosterone levels are in the therapeutic “natural” range.
I saw a bodybuilder who posted his bloodwork while he was preparing for a competition, and it was super insightful into the effects intense dieting has on the body because he's a natural athlete.…
There are a lot of strong opinions about how long kits of GH and peptides last before degrading in room temperature, versus in a fridge, versus in the freezer.
Most people are getting these products through black market means.…
What's the first product you should use for hair loss prevention?
Obviously, there are a lot of drugs and chemicals on the market when it comes to hair loss prevention.
There's a lot of junk, there's some stuff that works, but they vary greatly in side effect profiles, and some make much more logical sense to use as introductory methods of intervention.…
Clascoterone, also known more commonly as its developmental code name CB-03-01 is a synthetic steroidal antiandrogen.
It acts as an androgen receptor antagonist and is being developed by Cassiopea as a potential treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern baldness).…
There have been a few videos I've done in the past on protein intake and diet hacks that will make it a lot easier to hit your daily requirements.
There's always the guys who pop in on there who try to argue that you don't need that much protein to recover properly, or that a high protein diet is dangerous.…
For most of us, preventing heart disease depends largely on our lifestyle, which means there's much that's in our power to maintain cardiovascular health while bodybuilding.
Despite fit looking physiques being portrayed as examples of optimized health, the reality is that bodybuilding is one of the most unhealthy things you can do from a cardiac perspective.…
There is a very common misconception in the bodybuilding community that androgen receptors downregulate during a steroid cycle, or during long-term steroid use.
A plateau in muscle gain is commonly attributed to this “androgen receptor downregulation”.
If you've ever cycled anabolics, you can also attest to the fact that during a new cycle the gains always seem to come within the first 8 weeks or so, and then the weeks following that it is typical to notice a blatant diminishing returns effect.…
This strategy can be used wherever you live, regardless of what school you are at.
While some of you guys might be in fraternities, or have thriving social scenes at the schools you go to, there are a lot of colleges and universities that have no parties, no night life, and are essentially just commuter schools.…
Obviously, trying to get shredded eating McDonalds every day is not the optimal way to diet.
This post is not meant to assert that you should diet down eating McDonalds every day, it is simply meant to illustrate how the metabolism works, and how daily calorie intake relative to daily energy expenditure is ultimately what will determine if you lose fat or not.…
Dorian Yates is highly regarded for his extreme work ethic.
He is often referred to as an example of hard work beating talent–or genetics.
Many truly believe that he was just such a hard worker in the gym that it allowed him to overcome genetic deficiencies and grind his way to six consecutive Mr.…
I'm sure you've noticed as the years progress that beta males and “soy boys” are increasing in exponential proportions.
Men in general are becoming more and more feminine.
A lot of people think it is associated with the decline in natural testosterone levels as time goes on.…
The definition of looking fit varies individual to individual.
Each one of us has a subjective feeling towards different body shapes and builds.
For many girls, their perception of muscular development is so vastly different from guys in the bodybuilding community, that they'll perceive someone like Taylor Lautner from Twilight the same way we'd perceive a Mr Olympia champion like Phil Heath.…
No. A diet with too many calories makes you fat.
The problem with insulin use in bodybuilding is that the protocols given out typically don’t make any logical sense.
The problem boils down to bodybuilders eating excessive amounts to match their arbitrary insulin dosages, as opposed to how a diabetic would use inuslin (the correct way) where the insulin dosage matches the diet.…
The only way to increase your penis size without pumps, stretchers, or manual exercises is by getting shredded.
When you want add new permanent size, a consistent jelqing and stretching regimen in conjunction with the Bathmate pump and a good extender to prevent turtling are the gold standard and will net you 2-3 inches in length and girth if you are religious about your routine.…
How many milligrams of Testosterone do men naturally produce?
3-10 milligrams per day, with the average being 6-7 milligrams per day.
What Is A Therapeutic Dosage Of Testosterone?When bodybuilders refer to Testosterone Replacement Therapy (TRT) dosages they’ll often state that 200 milligrams is a therapeutic dosage.…
The first thing I want to make clear in regards to my Dutasteride and Testosterone experiment is that DHT is the worst hormone in your body for your hair.
I don’t want anyone to misinterpret my videos and articles exhibiting the androgenicity of Testosterone as disregarding how bad DHT is.…
What you need to understand about hair loss is that there are two types.
One is male pattern baldness, which is the acceleration of hair permanently being lost via androgen miniaturization at the hair follicle, which is what most guys are experiencing.…
The potent synthetic androgen Trestolone, also known as 7α-methyl-19-norTestosterone (MENT), does not require 5α-reduction to exert its' maximal androgenic effects.
It is an Anabolic Androgenic Steroid (AAS), which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low Testosterone levels in men but has never been approved for clinical usage.…
If you read my last update, basically what had happened was I delved into my blood work and talked about my cholesterol being a big concern.
I’ve been following the Vertical Diet to a tee exactly how Stan would advise it, and was eating one pound of lean 90/10 ground bison per day, 4 eggs per day, long story short I was hitting all the diet goals outlined in the book relative to my body’s individual specific energy requirements for my current goals.…
In this day and age of social media, if you follow bodybuilding you probably follow a lot of fitness models, as well as people who compete in physique, classic physique, or bodybuilding.
Using these social media presences as inspiration creates an illusion that the ideal physique for men is 200 pounds diced as a minimum, and that men's physique competitors are likely the minimum level of muscularity necessary for a maxed out physique.…
Podcast #2 – Chris Deoudes (Good Looking Loser)
In this podcast I sit down with Chris and we talk about how he got kicked out of a fraternity, how to have a great college experience, partying and the best party schools, accepting personal responsibility for not having women in your life, how to be emotionally stable with girls out of your league, cold approach, Chris' Physique Stats When He Attracted The Most Girls, and more.…
I see A LOT of misinformation on the Internet in regards to hair loss (male pattern baldness/androgenic alopecia).
Especially when it comes to why it occurs on a hormonal level, and the mechanism of action behind what is actually happening to your hair follicles.…
Does time on = time off?
How much time should I take off after a steroid cycle after PCT?
I get these kind of questions all the time.
Regardless of what suppressive anabolics you were on (SARMs, AAS, Prohormones, etc.) PCT is a necessity.…
There is a lot of confusion regarding which is more effective, SARMs Liquid Vs Capsules.
There are several ridiculous theories and false statements thrown around the community purporting that liquid SARMs are more effective than capsules/pills, and most of the time these statements are simply deriving from misinformed individuals, or those who have vested interest in the profitability of liquid SARMs (AKA they own/work for/are paid by a company who sells liquid SARMs).…
One very common question I get asked is about SARMs and high Estrogen side effects.
One of the biggest myths circulating in the community is that SARMs cannot cause Estrogen related side effects because they don’t aromatize into Estrogen, and if you do experience high Estrogen side effects then you have “fake SARMs” or “Prohormone laced SARMs.”…
There is a belief that is widespread in the bodybuilding community that using HGH, MK-677, or other GH releasing peptides will cause your intestines to grow, start protruding outwards, consequently giving a very unaesthetic distended look of the abdominals known as GH gut.…
If you don’t already know what RU58841 is, it is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness).
If you haven’t read my overview article on RU58841 check it out here:
There are a lot of myths surrounding the proper storage of this research chemical, and I’m going to quickly clarify every thing for you in this quick article.…
I have had a prescription for Modafinil for a few years now, and I have quite the thorough experience with the stuff to say the least.
Before you jump to the conclusion that I have (or faked having) ADD/ADHD symptoms to get a prescription, let me preface this by saying that Modafinil IS NOT a drug prescribed to treat attention deficit disorder symptoms.…
RAD140 is a selective androgen receptor modulator (SARM) currently under development for potential use in treating muscle wasting disorders and hormone-receptor positive breast cancer.
For those that are just here find out where to buy accurately dosed, third party tested RAD140, these are the only companies I currently use for my own personal research:
(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)
Proven Peptides – 10% off coupon code “DC10”
S4 (Andarine) is an abandoned selective androgen receptor modulator (SARM) that was intended mainly for treatment of benign prostatic hypertrophy.
For those that are just here find out where to buy accurately dosed, third party tested S4, these are the only companies I currently use for my own personal research:
(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)
Proven Peptides – 10% off coupon code “DC10”
LGD-4033 is a selective androgen receptor modulator (SARM) currently being researched for its potential applications in the clinical treatment of muscle wasting, osteoporosis and other related conditions.
LGD-4033 is purported to be the most potent SARM currently in clinical trials, with its data exhibiting the most favorable ratio of anabolic activity relative to androgenic activity.…
Ibutamoren (developmental code name MK-677) is an orally-active growth hormone secretagogue and ghrelin receptor agonist being researched as a potential treatment for growth hormone deficiency and sarcopenia [R, R, R, R, R].
For those that are just here find out where to buy accurately dosed, third party tested MK-677, these are the only companies I currently use for my own personal research:
(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)
Proven Peptides – 10% off coupon code “DC10”
Ostarine is the most well known and extensively studied selective androgen receptor modulator (SARM) right now.
It is categorized as a SARM because of its unique selectivity at the androgen receptor where it exhibits a significant amount of anabolic activity in the body relative to androgenic activity.…
En liten tjänst av I'm With Friends. Finns även på engelska.