LSD & Psychedelic Chemistry

Lysergic acid diethylamide (LSD) is one of fungi’s most well known chemical analogues. Today we bring you a leading scientist, Dr. David Nichols who speaks to the history, chemistry, legality and so much more of this notable compound. 

 Topics covered:

• David Nichol’s career pursuing psychedelic pharmacology
• Patent litigation, especially with psychedelic constituents 
• Lab testing for new psychedelic analogues in rats
• Bureaucracy of working with Schedule I substances
• How to synthesize LSD
• LSD’s physical characteristics, structure and fluorescence
• What happens to the LSD molecule when you adjust minute aspects, and what that tells us about itself
• Structural similarities and differences in an array of psychedelic molecules / chemical ‘templates’ for psychoactive compounds
• Neuro-mechanics of LSD and other entheogenic compounds
• Evolution and function of serotonin receptors
• HPPD: Hallucinogen Persisting Perception Disorder
• Trepanation: how does it affect neurochemistry, if at all?
• NBOMes (N-benzyl methoxy): What is it and how does it work?
• Metabolizing LSD and related compounds
• Chirality in psychedelics, especially LSD
• Listener questions

Show notes:

Hamilton’s Pharmacopeia feat. Dr. Nichols: https://www.youtube.com/watch?v=7N4VoqeuK3s

Hallucinogens (2004) : https://pubmed.ncbi.nlm.nih.gov/14761703/

DEA 222 - https://dehs.umn.edu/using-dea-form-222-order-controlled-substances

Mapping the Mind Talk: https://www.youtube.com/watch?v=6hfsIbib_50

MAPS Talk: https://www.youtube.com/watch?v=TxjCSKMbZBA

Telluride Keynote presentation: https://www.youtube.com/watch?v=RlDCM5JQzRk

Leo Perutz & the Mystery of St Peter’s Snow: https://www.tandfonline.com/doi/abs/10.2752/175169713X13589680082172

Trepanation articles & video: https://lostmediawiki.com/Heartbeat_in_the_Brain_(partially_found_Amanda_Fielding_trepanation_documentary;_1970)

Downloadable literature: https://drive.google.com/drive/folders/14N9VdXGFlLvjnShYRH2MRurNi54a77Ig?usp=sharing

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