Obstetrics & Gynecology Medical Conversation Video

Advanced or recurrent endometrial cancer: Molecular classification and treatment decisions

Key clinical takeaways:  

• MMR status should be tested in all patients at diagnosis and upon disease progression to guide personalised treatment decisions  

• ICI and ChT combination, including with maintenance olaparib, demonstrates benefits in patients with non-dMMR advanced/recurrent endometrial cancer, with greater efficacy observed in dMMR populations 

• Lenvatinib plus pembrolizumab is a viable option not only as 2nd line therapy but also as 1st line treatment for patients with non-dMMR advanced/recurrent endometrial cancer who have progressed after prior systemic therapy in any setting 

• Shared decision-making, supported by patient education, is essential for optimising treatment outcomes  

The treatment landscape for advanced and recurrent endometrial cancer (EC) is evolving, with molecular classification playing a key role in guiding decisions. In this podcast, Prof. Xavier Matias-Guiu (Pathologist) and Dr Jurjees Hasan (Medical Oncologist) discuss the latest advancements in personalised treatment approaches for EC. 

Key topics include: 

• The role of molecular classification in guiding treatment selection and testing strategies 

• Treatment options for patients with pMMR status 

• Effective patient communication for shared decision-making 

Tune in for expert insights and practical guidance to optimise treatment strategies in advanced and recurrent EC 

You can also watch a video of the experts in conversation and download the accompanying transcript on our website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/endometrial-cancer-molecular-classification-treatment-decisions/ 

Or watch on YouTube: https://youtu.be/KvYIB7PBpyQ 

Follow us on social media: 

LinkedIn: https://www.linkedin.com/company/ob-gyn-connect/?viewAsMember=true  

X: https://x.com/OBGynConnect  

This content is intended for healthcare professionals only. 

The medical experts in this podcast are expressing their own views and not those of COR2ED, Supporters or their institution.  This programme has been sponsored by Eisai Europe Limited ("Eisai"). Eisai has had no input on the educational content of, or speakers involved in this podcast. 

This podcast is developed by cor2ed.com 

Published February 2025 

Subscribe to this channel to stay up to date with new Independent Education programmes as they’re released. 

Appropriate management of postpartum hemorrhage (PPH) requires prompt diagnosis and treatment. However, there's some debate on various PPH prevention and management strategies and the corresponding scientific evidence. What do you believe is the right strategy to prevent and treat PPH?

In this third episode of a four-part podcast series on severe PPH, Prof. Loïc Sentilhes (Professor of Obstetrics and Gynecology, Chairman of the Gynecology and Obstetric Department at Bordeaux University Hospital, France) and Prof. Christian von Heymann (Chief Physician of the Clinic for Anesthesia, Intensive Care Medicine and Pain Therapy and Medical Director at the Vivantes Clinic in Friedrichshain, Germany) discuss various topics on the treatment of severe PPH, and we also explore the scientific evidence combined with the clinical experience of the experts.

With Dr Homa Ahmadzia as moderator, experts share learnings from their own clinical practice and explore: (1) The role of prophylactic tranexamic acid to prevent PPH, (2) When to initiate blood transfusions or other blood products, (3) Pharmacological treatments and their use and (4) The importance of multidisciplinary collaboration in the management in PPH.

Prefer to watch as well as listen?

Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatments/

Or go to the video on YouTube: https://youtu.be/e9hEa5tczZo?si=H6jrK6PwIsXtQZuZ

We are pleased to share that this podcast is endorsed by UNITE GLOBE (UNITed Efforts to reduce GLobal OBstetric HemorrhageE). You can find out more about UNITE GLOBE at https://ahmadziaresearch.smhs.gwu.edu/unite-globe

The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk.

This educational podcast is developed by cor2ed.com.

Innovation is the key to achieving success in the future, including recent scientific research to explore novel therapeutic options to improve the treatment of severe postpartum hemorrhage (PPH). If you're curious about the latest advancements in this field and how they can impact future treatment strategies for women who suffer from severe PPH, then listen to the fourth and final part of a podcast series on severe PPH.

Experts will discuss the latest treatment advances and their perception of how the management of PPH will evolve in the future.

Don't miss out on this opportunity to learn more about the latest scientific breakthroughs that can transform the lives of women suffering from PPH.

Prefer to watch as well as listen?

Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatment-developments/

Or go to the video on YouTube: https://www.youtube.com/watch?v=6HXtMNxgr1c

The medical experts in this podcast express their own views, not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk.

This educational podcast is developed by cor2ed.com.

Appropriate management of postpartum hemorrhage (PPH) requires prompt diagnosis and treatment. However, there's some debate on various PPH prevention and management strategies and the corresponding scientific evidence. What do you believe is the right strategy to prevent and treat PPH?

In this third episode of a four-part podcast series on severe PPH, Prof. Loïc Sentilhes (Professor of Obstetrics and Gynecology, Chairman of the Gynecology and Obstetric Department at Bordeaux University Hospital, France) and Prof. Christian von Heymann (Chief Physician of the Clinic for Anesthesia, Intensive Care Medicine and Pain Therapy and Medical Director at the Vivantes Clinic in Friedrichshain, Germany) discuss various topics on the treatment of severe PPH, and we also explore the scientific evidence combined with the clinical experience of the experts.

With Dr Homa Ahmadzia as moderator, experts share learnings from their own clinical practice and explore: (1) The role of prophylactic tranexamic acid to prevent PPH, (2) When to initiate blood transfusions or other blood products, (3) Pharmacological treatments and their use and (4) The importance of multidisciplinary collaboration in the management in PPH.

Prefer to watch as well as listen?

Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatments/

Or go to the video on YouTube: https://youtu.be/e9hEa5tczZo?si=H6jrK6PwIsXtQZuZ

We are pleased to share that this podcast is endorsed by UNITE GLOBE (UNITed Efforts to reduce GLobal OBstetric HemorrhageE). You can find out more about UNITE GLOBE at https://ahmadziaresearch.smhs.gwu.edu/unite-globe

The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk.

This educational podcast is developed by cor2ed.com.