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Plenary Session
A podcast on medicine, oncology, & health policy.
387 avsnitt • Längd: 65 min • Veckovis: Fredag
Om podden
A podcast on medicine, oncology, & health policy.
Host: Vinay Prasad, MD MPH from University of California, San Francisco.
Tweet your feedback to @Plenary_Session or e-mail [email protected].
The podcast Plenary Session is created by Vinay Prasad, MD MPH. The podcast and the artwork on this page are embedded on this page using the public podcast feed (RSS).
Avsnitt
Systematic Reviews - An Introduction⧸ How to do them⧸ Search Strategies⧸ Common Errors
13 november 2024 |
49 min
Lecture on systematic review, given by Vinay Prasad MD MPH to students in the UCSF Training in Clinical Research Program, November 2024.
Special post-ESMO 2024 edition !
3 november 2024 |
31 min
Timothee Olivier and I discuss the top ESMO 2024 abstracts!
Artificial Intelligence in Medicine - My Keynote
28 oktober 2024 |
59 min
AI in healthcare - my latest keynote address
Masking Mistakes - my panel discussion at the Emory Center for Ethics
16 oktober 2024 |
97 min
"Masking Mistakes: Lessons from the Science, Policy, and Coverage of COVID-19", the 2024 Brian Shields Lecture on Institutional Ethics which took place on Monday, October 7, 2024 for the Emory Center for Ethics. A conversation with Carlos Del Rio, MD and Vinay Prasad, MD MPH with moderation by Gerard Vong, DPhil, Director of the MA in Bioethics program.
How We Can Do Better As A County Hospital
31 augusti 2024 |
42 min
Screening/ Drug efficacy/ Sotorasib/ Adaura and more
Driver mutation lung cancer - My lecture
2 augusti 2024 |
37 min
My UCSF lecture on driver mutation lung cancer
Post ASCO wrap up with Timothee Olivier
23 juni 2024 |
45 min
We break down the best studies from ASCO
Critical Appraisal - My 2 hour ASCO lecture - Day 2 version
5 juni 2024 |
114 min
Critical Appraisal - My 2 hour ASCO lecture - Day 2 version by Plenary Session
Asco Prequel - We talk about what to look for
30 maj 2024 |
30 min
What you need to know in advance of ASCO
A SM crossover - Cifu, Prasad, Mandrola
27 maj 2024 |
45 min
Should trials have carbon footprint as an endpoint?
When Evidence EXPIRES - My Grand Rounds Today at Mt Sinai
17 maj 2024 |
53 min
My grand rounds; Beta blockers post MI
Single center vs multicenter RCT
Masks
Boosters and more
Cifu, Mandrola, Prasad - SM crossover
10 maj 2024 |
42 min
I crossover SM podcast; Harvard med students video, Justice curriculum, Masking half the year
Patient advocates funded by Pharma
17 april 2024 |
26 min
Patient advocates, Pharma funding, and is MRD a suitable endpoint
FDA makes MRD the basis for AA
12 april 2024 |
9 min
5 reasons that is a bad idea
Beta Blockers After Heart Attacks Don't Work
9 april 2024 |
16 min
Another flawed quality metric. Reviewing the NEJM paper "Beta-Blockers After Myocardial Infarction and Preserved Ejection Fraction".
Blood based and Stool DNA colon cancer screening - Two NEJM papers
27 mars 2024 |
26 min
They are shitty
Keynote 564 - a flawed study
1 februari 2024 |
18 min
Another flawed study Keynote 564. Pembro in adjuvant RCC
CONTACT-01 Cabo/ Atezo in Prostate Cancer - An Unethical trial
27 januari 2024 |
25 min
What happens when doctors run unethical studies?
CAR T causes MDS??? Manni, Goodman, Raj, Prasad
28 december 2023 |
27 min
Does car T cause secondary AML?
We discuss
Timothee and Prasad talk 2023 cancer trials
24 december 2023 |
44 min
We talk about 2023 cancer trials
Aaron Goodman Prasad ASH UPDATES
20 december 2023 |
53 min
Goodman and I discuss ash updates.
My myeloma talk
https://www.youtube.com/watch?v=jAz84yCnfjQ
Mandrola and Prasad
17 december 2023 |
50 min
Subscribe to Sensible Med Pod; This is x over
Post partum depression, orbita 2 and physics vs medicine
COVID19 Policy: What the US Got Wrong
26 november 2023 |
88 min
My Lecture in Curacao 4/4
Vaccines, Masks, Mandates, Lockdowns, School closure
Other lectures to come
Lecture 1 of 4 Curacao - How to Keep Up with Literature
24 november 2023 |
42 min
Entresto, Lung Transplants, How to Keep Up with Literature - Lecture to Trainees in Curacao
Advice Pre-Med Students | Lecture at UC Berkeley
11 november 2023 |
48 min
This is a lecture I gave on November 5, 2023, to pre-medicine undergraduate students at University of California Berkeley.
Radiation oncology in GI malignancy - Nina Sanford and Bill Hall
31 oktober 2023 |
24 min
Radiation oncology in GI malignancy (endpoints and stratification) in the JCO
Hawai Keynote - Coffee and colon cancer & Censoring & More
23 oktober 2023 |
46 min
Prasad is back in Hawaii to give another keynote (good thing they cancelled Dallas not Honolulu). I discuss coffee and colon cancer, and censoring, and Lu177 PSMA
Ethics: How IRBs Can Do Better | My Denmark Lectures (Sept 2023) 3 Of 3
19 oktober 2023 |
43 min
This is a lecture I gave on ethics and institutional review boards in Denmark in September 2023. It is the last of the three lectures I gave.
Prasad's lecture gets cancelled/ Cifu Gets COVID a SM crossover
16 oktober 2023 |
55 min
Mandrola, Prasad and Cifu are back to discuss the latest drama
The State Of Immunotherapy In Oncology | My Denmark Lectures (Sept 2023) 2 Of 3
9 oktober 2023 |
46 min
This is a lecture I gave on the state of immunotherapy in oncology at the Immunotherapy Symposium In Denmark in September 2023. It is the second of three lectures I gave.
Do We Have Good Evidence For New Drugs? My Denmark Lectures (Sept 2023) 1 Of 3
4 oktober 2023 |
76 min
The first of the three lectures I gave in Denmark in September 2023 was on the medical evidence behind decision-making by health technology assessment groups.
Great And Crazy Things We Do In Medicine
20 september 2023 |
115 min
This is the live recording of a talk given on the great and crazy things we do in medicine, from cancer drugs to boosters and more.
Fixing Cancer Medicine w/ Timothee Olivier
12 september 2023 |
43 min
Timothee is back to discuss Malignant and Solutions
Coumadin, ECMO, RCTs and more
11 september 2023 |
49 min
A far reaching discussion btw Mandrola and Prasad on RCTs, Coumadin, ECMO and RCTs for covid shots
Prasad and Mandrola discuss recent journal articles/ Republicans/ Stenting
23 augusti 2023 |
43 min
Simultaneously released on Sensible Medicine. Time to subscribe to Sensible Medicine substack and podcast.
Placebo/ Journal Errors/ Cancer Screening w/ Mandrola - SM crossover
10 juli 2023 |
83 min
Placebo/ Journal Errors/ Cancer Screening w/ Mandrola - SM crossover
Testosterone/ Should Scientists Debate/ Mike Joyner
28 juni 2023 |
59 min
A sensible medicine crossover episode
Follow the sensible medicine podcast feed for more of these discussions
Post Protocol Therapy - QOL - Adjuvant - Olivier Joins VP
10 juni 2023 |
41 min
T. Olivier from Geneva is back. A fan favorite guest. We discuss 3 recent papers.
ADAURA OS RESULTS - THE TRIAL WAS UNETHICAL
8 juni 2023 |
24 min
Researchers were too busy counting dead bodies to give the control arm appropriate therapy when their cancer recurred. Disgusting conduct.
I break down ADAURA
OBS studies vs RCTs - Trial Emulation - RCT Duplicate - We debate recent JAMA Paper
17 maj 2023 |
75 min
Mike Putman, Todd C. Lee, John Mandrola and I debate the recent JAMA paper on RCT Duplicate. This is a spirited round table discussion on the limitations of observational data. If you are reading this, leave a comment as a review!
Myeloma Roundtable - Manni M. Raj C. VP discuss controversies
13 maj 2023 |
81 min
Early treatment of myeloma, dual vs. single maintenance, and finally transplant or no transplant.
Mammographic Screening : A complete review of the evidence
11 maj 2023 |
37 min
Why the USPSTF is wrong
The Crushing, Cruel Cost of Cancer Drugs - My Lecture
29 april 2023 |
31 min
Cost of Cancer drugs - VP's lecture
Sensible Med Crossover - Cifu/ Mandrola/ Prasad & Wallensky
24 april 2023 |
84 min
I combine two latest tracks on interpreting medical studies, medical boards, 7 doses of vaccine, and finally Walensky. Stay tuned.
Cochrane Mask Debates - Jefferson/ Heneghan/ Prasad
15 april 2023 |
78 min
We explore the fight btw NYTimes, Cochrane, and the last people keeping EBM alive
Zeb Jamrozik - Vaccine errors/ Sweden/ Equipoise & Science itself
12 april 2023 |
73 min
Zeb joins me for the 7th time to discuss all the key pandemic questions
Harvard-MIT Center for Reg. Science Lecture (4-4-23) - Dubious FDA drug Approvals
5 april 2023 |
58 min
My lecture to Harvard regulatory science
5.47 - Real World Evidence - Keynote Lecture in Denmark
26 mars 2023 |
49 min
VP goes to Denmark to give the keynote at the Danish medical association conference
5.46 - What is Science: reflections on the field
10 mars 2023 |
30 min
What is science?
5.45 - Bar Karmma - Karmma 3 | Idacel vs 'standard care
7 mars 2023 |
112 min
Karmma 3 discussion; then Sensible Medicine on Long COVID, 4th year fellowships and more; Then my breakdown of FDA's NEJM Letter to the Editor
More basics on randomized controlled trials - Part 2
2 mars 2023 |
43 min
I get into endpoints, surrogates, validation, blinding, crossover, and control arms.
RCT 101 And Papa Heme
28 februari 2023 |
70 min
I talk RCTs 101; KM Plots; Blinding: 2:1 randomization: Concealment and more. Then Papa Heme Tells you How to Find your First Job
Tom Newman And VP Discuss Public Health
22 februari 2023 |
57 min
Dr. Tom Newman UCSF Emeritus Professor & Superb teacher discusses VP's recent Public Health Videos. The two don't fully agree, but the discussion is worth your time.
5.41 - Michael Putman MCW debates me on recent policy Qs
16 februari 2023 |
67 min
Mike Putman, asst prof. EBM Rhematologist debates me on value of boosters, observational studies and more.
Sensible Med Superbowl Plenary Session Crossover
13 februari 2023 |
54 min
A new podcast feed called Sensible Medicine is up; here is a sample of what we have to offer
5.39 - Sotorasib and Codebreak 200
10 februari 2023 |
45 min
I destroy the trial. Bad control arm. Informative Censoring. No OS gain. Authors DOWNPOWERED TRIAL. Fishy PFS. Fishy HRQoL. This trial should be in trash can.
Myeloma Twitter Just Makes Things Up - Lessons for All Oncologists & Expertise
22 januari 2023 |
42 min
I annotate an online case discussion; Every decision is not based in evidence. Madness
5.37 - Keynote Lecture on Physician Burnout
15 januari 2023 |
40 min
This lecture on Burnout will not be like any other you have heard
5.36 - ASH UPDATE #4 - GEM CESAR
30 december 2022 |
22 min
I break down the GEM CESAR trial
K, R, D, Pom, Dara, Dex, R, and Auto and all before you actually have cancer
What a crazy trial!
5.35 - ASH Update #3 - the Ascent Trial
29 december 2022 |
19 min
This uncontrolled trial of Dara-KRD claims to be looking for cure; Unfortunately, the PI has not thought through what that would look like, and accordingly all the claims are incorrect. Moreover the primary endpt is negative. Sad day for oncology
5.34 - ASH Update #2 - ALPINE - Zanibrutinib vs Ibrutinib - Deconstructed
24 december 2022 |
22 min
Sample size games, primary endpoint, head to head trials in oncology
Rate this podcast on itunes
Coming next is Triangle trial
5.33 USC Grand Rounds Hematology
23 december 2022 |
48 min
Grand rounds on heme and heme malignancies given 12/16 at University of Southern California (some parts removed)
More ASH coming soon
5.32 - ASH Update #1 - Talquetamab NEJM
11 december 2022 |
18 min
Is it acceptable to take someone with myeloma who has gotten just 2 regimens and put them on a phase 1? VP says hell no.
5.31 - MUST LISTEN Grand Rounds - COVID19 Updates
8 december 2022 |
55 min
In this lecture given December 7, 2022, I cover 5 things:
Vaccines
Masking
Long COVID
Schools/Immunity Debt
Paxlovid
5.30 Rajkumar vs Goodman; Long COVID vs Long URI
3 december 2022 |
41 min
Should we treat smoldering MM, a debate
Long COVID vs Long URI
Review the show; Say Hi at ASH22
5.29 Smart Start is a useless Lymphoma study
27 november 2022 |
50 min
Smart Start is a useless lymphoma study; We have to stop putting our careers ahead of patients. In the second part, I discuss the 'experts' featured on STAT. Wowzers.
I will be at ask. Hit me up:
[email protected]
5.28 - Pandemic Amnesty or Accountability with Paul Fenyves
12 november 2022 |
38 min
I am joined by Cornell Professor Paul Fenyves; a practicing internist Dr. Fenyves walks us through COVID19 policy. We will be back soon with more cancer medicine. Including a devastating lymphoma one.
5.27 - Multiple Myeloma - Do Our Trials Help Patients?
8 november 2022 |
28 min
I was invited to give this talk to a UK conference on Myeloma
Please LEAVE A REVIEW of this podcast
5.26 - Hawaii Oncology Association Keynote Lecture
6 november 2022 |
44 min
Lecture I gave this weekend in Hawaii to the Medical Oncology Association; One of the best audiences I've had
5.25 - Neurosurgery Grand Rounds by Vinay Prasad
3 november 2022 |
72 min
I give Grand Rounds to UCSF Neurosurgery on how to read and interpret Neurosurgery Studies
(Video and slides coming soon to YouTube)
Also I discuss Bob Califf's Promotion of Paxlovid
5.24 Vlad Kogan is back to discuss Kids Test Scores
1 november 2022 |
80 min
Learning Loss is Devastating; Here are the data and what it means
5.24 - Gerald Hsu MD PhD UCSF Heme Onc Program Director
28 oktober 2022 |
68 min
Learn about UCSF Hematology Oncology Program with Dr. Gerald Hsu, MD PhD Malignant Heme and Program Director
5.23 - Subclinical Myocarditis
19 oktober 2022 |
13 min
A new study from Switzerland confirms the rate of subclinical myocarditis
5.23 - ID Ethicist joins me for a 6th discussion of COVID19 policy
18 oktober 2022 |
89 min
LONG COVID, Vaccines, Paxlovid and More
5.22 NordICC trial interview with PI Michael Bretthauer - Offer but don't Nudge
15 oktober 2022 |
69 min
discuss NordICC with the trial PI
Power calc specified 50% non-adherence
ADR is on par with US studies from the time
Colo quality good
Perf rate lower than US!
How does he counsel individuals & governments
What he thinks of USPSTF
5.21 Science Mag Editor Condemns Ladapo But Silent About Jha
14 oktober 2022 |
35 min
A double standard to condemn data with limitations, based on political party, will destroy medicine.
We will back to oncology soon, but this is important
5.20 The Great Colonoscopy Debate
11 oktober 2022 |
61 min
Cifu, Mandrola and Prasad fight about colonoscopy
5.19 - NEJM's first ever RCT of Colonoscopy-- Explained
9 oktober 2022 |
31 min
I break down the history and data for the first ever randomized trial of colonoscopy, appearing in NEJM on Oct 9, 2022
5.18 Lecture to Heme Onc Fellows - POLO; Javelin 100 bladder
8 oktober 2022 |
47 min
Polo Javelin 100 bladder Crossover Control arms How to read and keep up with the literature
5.17 - The State Of Precision Oncology
7 oktober 2022 |
15 min
Invited Lecture to Cancer Center Directors
5.16 - Aaron Goodman UCSD
29 september 2022 |
94 min
I travel to UCSD to interview Dr. Goodman about myeloma, celebrity oncology culture, his career, education, patient care, choosing a specialty and more.
5.15 - How To Apply For And Get Your Perfect First Job
21 september 2022 |
36 min
Based on listener questions, I discuss how to apply for and get your first job.
Unspoken Rules of Oncology - Malignant BC Part 6
18 september 2022 |
63 min
T.O. joins me for the missing episode. These are the unspoken rules of Oncology; We dive deeper into Malignant Book Club.
Malignant Book Club - Episode 7 - famous trials
9 september 2022 |
42 min
Timothee Olivier joins me for the 7th installment of our book-club
We cover famous trials in oncology
5.12 - Academics Vs Industry - A.Goodman S.Loghavi D.Steensma V.P.
3 september 2022 |
90 min
How do careers vary between the academy and industry? We have a panel of the best: Sanam Loghavi from MD Anderson, Aaron Goodman UCSD, and David Steensma Novartis (formerly Farber/ Mayo) and VP
#Real talk
5.11 - Malignant Book Club - Part 5
26 augusti 2022 |
53 min
Timothee Olivier joinrs me as we explore part 3 of the book
Crossover, sample size, observational vs RCTs
5.10 - Adam Cifu on clinical excellence
24 augusti 2022 |
68 min
Adam Cifu is here to discuss clinical excellence and his new podcast
5.09 - Malignant Book Club Part 4
22 augusti 2022 |
60 min
T.O. joins me to grill me on the rest of Financial Conflict of Interest and Precision Oncology. We discuss the need for randomization, and when it can be omitted. A must listen for Oncology Fans.
5.08 - LaceWing RCT Phase 3 Blood - Spin Cycle
18 augusti 2022 |
34 min
VP discusses the LaceWing study in Blood. A Phase 3 RCT of GILT AZA vs AZA; Medical writers; confounding; table 1; balance; and so much more
5.07 - Plenary Session Alps Edition
10 augusti 2022 |
59 min
Timothee Olivier joins me to discuss recent papers:
IMPOWER10
Checkmate 816
Path CR/ EFS/ Surrogates
Drug Dosing, cGCSF rules and more
Bread and butter oncology
5.06 - POLO trial now has OS results - OMG
21 juli 2022 |
31 min
The POLO trial, which we first broke on PS Season 1- is back with null OS results. But the trial authors enter the spin cycle. VP goes line by line.
5.05 - Citations, Metrics, Rankings in Oncology & Medicine
18 juli 2022 |
37 min
VP explains H index, total cites, papers, US News and World Report rankings and how evaluates researchers and doctors.
5.04 - Echelon 1 reports OS benefit - But does it add up?
14 juli 2022 |
39 min
VP addresses what to do you if you get an idea from listening to the show, and deconstructs ECHELON-1. Instead of listening we highly recommend you watch the video on YouTube with graphics. This is worth the watch.
5.03 - VPs Grand Rounds Lecture - Evidence Based Medicine - Will it Survive?
13 juli 2022 |
51 min
How to think about when and how to do RCTs? What are the limitations to observational studies? Smoking. Parachutes. Dostarlimab. Guarantee Time Bias. Confounding. Multiple Hypothesis testing and more
5.02 - Listener Questions - Cancer & Evidence Philosophy - What this Pod Offers
11 juli 2022 |
47 min
I make the case why this podcast should be your go to for Med, Onc & Policy. I describe my philosophy of Evidence, Empiricism, and show how this connects to many oncology studies. I answer a bunch of Listener Questions
5.01 - How To Read Randomized Trials In Cancer
7 juli 2022 |
38 min
How to read randomized trials in cancer medicine. Phase 2 vs 3, control arm, crossover, post protocol, censoring (the basics), and how law professors and medical professors are different and why it matters.
Lies and Exaggerations about Kids Vaccines < 5 years Old is Bad Public Health
22 juni 2022 |
19 min
Lies and Exaggerations about Kids Vaccine
I give examples, and show why they are lies
Enact Trial - Enza vs Active Surveillance in Localized Prostate Cancer
20 juni 2022 |
15 min
What happens when you treat people with $168,000 a year medicine when most of them will never need treatment, and all of them don't need treatment now
Kids Vaccine For Under 5 years Old
18 juni 2022 |
43 min
I take a deep dive into the data for the mRNA vaccines for kids under 5 years olds
H. Jack West; Lung Cancer; Podcasting; TeleHealth: PACIFIC; ADAURA;CM816: KN189
18 juni 2022 |
77 min
I sit down with H Jack West. City of Hope. Thoracic Oncology and we have a long discussion about trials; staging; PDL1 thresholds; Driver mutations and post protocol care; ADAURA; Adjuvant; & More
QuANTUM - Quizartinib Front Line - Ethics of Global Trials
15 juni 2022 |
42 min
I discuss the timeline of Ratify and Quantum. Was this an ethical trial? Is it sufficient to say a trial is ethical because 50% of participants get something?
4.67 Teclistimab for R/R Multiple Myeloma
9 juni 2022 |
38 min
The drug has a high response rate and lots of infections, is it active? Yes; Efficacious? ???? I review ASCO2022 updates
4.66 PD1 Ab for MSI H Stage II/ III Rectal Cancer; A 100% CR rate??
8 juni 2022 |
24 min
Are the results from Luis Diaz as good as touted. What trial should they do going forward?
A 100% CR rate in Stage II and III rectal cancer??
4.65 DESTINY BREAST 04 - A complex trial to deconstruct
7 juni 2022 |
32 min
My take on the standing ovation for DESTINY Breast 04
Traztuzumab Deruxtecan vs. Investigator choice after endocrine therapy and 1 or 2 chemotherapies for HER2 low
4.64 - DETERMINATION - Should we still use transplant Myeloma?
6 juni 2022 |
32 min
I break down Richardson, et al. NEJM DETERMINATION
Transplanters are determined to keep going, should they be?
Watch the videos b/c I have lots of great visuals
My ASCO Coverage continues
4.63 - ASCO22 - DYNAMIC - Can CT DNA Allow us to Give Less Chemo in Stage II Colon Cancer
5 juni 2022 |
35 min
The second paper from #ASCO2022 #ASCO22 that I break down
This is one of the most technical papers I breakdown on the channel
CT DNA used to omit chemo in Stage II colon cancer
Read the book Malignant if you learn from this
Watch the YouTube Figures https://youtu.be/QxOBIi7I2BU
4.62 - SHINE - Ibrutinib BR vs BR; Limitations to the trial
4 juni 2022 |
18 min
Continuous vs. Fixed, 3 vs 2, PFS is the primary endpoint
No OS
Bad crossover
Lots to discuss here
I will be covering all the major ASCO papers on @PlenarySession
Subscribe to my substack https://vinayprasadmdmph.substack.com/
4.61 - How CDC's Vaccine Safety Missed Cases Of Myocarditis
27 maj 2022 |
55 min
I am joined by Dr. Katie Sharff, infectious disease doc, to discuss two of her papers on myocarditis after COVID-19 vaccination.
https://doi.org/10.1016/j.amjcard.2022.02.039
https://doi.org/10.1101/2021.12.21.21268209
4.60 - NEW JCO paper - AML, EFS, CR, CRi, and Surrogate validation - FDA & Methods
21 maj 2022 |
34 min
I get back to my roots; I explain surrogate validation and a new JCO paper from the FDA authors on EFS and OS in AML. You won't want to miss it
4.59 - How to be a better reader of case control studies
17 maj 2022 |
19 min
In this episode I dissect a test negative case control trial; I talk about a famous pancreas cancer study and I revisit the failure of Myeloma trialists
4.58 - Myeloma is a broken field - New BLOOD Paper!
14 maj 2022 |
63 min
I am joined by Manni Mohyuddin to talk about How I treat frontline transplant eligible myeloma. Vinay Prasad makes the case the entire field of myeloma is corrupt and broken.
4.57 - COVID19 and the Failures of Public Health w/ Leslie Bienen
6 maj 2022 |
82 min
I join Dr. Bienen in person to discuss COVID19 and failures in public health
4.56 - Fifth Installment of the brilliant Zeb Jamrozik
4 maj 2022 |
84 min
ID ethicist, and brilliant COVID19 commenter
4.55 - Compilation Of Recent Covid Monologues
1 maj 2022 |
73 min
This is a compilation of the last week and half of monologues by VP on his Youtube Channel about COVID19 policy
4.54 - Eric Collisson Professor, GI Oncologist, Physician Scientist
30 april 2022 |
55 min
I talk to UCSF Professor Eric Collison about his lab, grant writing, the physician scientist life, cancer, and a doctors duty.
4.53 John Ioannidis lectures the VKPrasad Lab about COVID19
27 april 2022 |
89 min
A brilliant talk by one of the most brilliant scientists alive; JPAI lectures VKPrasad lab on all things COVID19; When does the pandemic end? What are the lessons?
4.52 Vinay Prasad Gives a Lecture on COVID19 to a General Audience
24 april 2022 |
42 min
Listen in as I give an unscripted lecture to a general audience about COVID-19; What we got right and wrong these last 2+ years.
4.51 - Vinay Prasad is Interviewed by Kristina Jenei About Academic Medicine
22 april 2022 |
79 min
Kristina Jenei becomes the 4th guest host and flips the tables on me, interviewing me about academic medicine and more...
4.50 - Ivosidenib & Aza vs Aza, the AGILE, 6 huge problems; Journal club
21 april 2022 |
20 min
I perform an analysis of the AGILE trial that came out in NEJM today; I find 6 huge problems. Follow PS on twitter; and write to us to let us know what you think
4.49 - Malignant Book Club Part 3 Audio
15 april 2022 |
44 min
Timothee Olivier joins me for the 3rd of 9 parts of the Malignant book club - this covers all of Oncology
4.48 - The Truth About RCTs In Cancer Medicine
7 april 2022 |
35 min
Pragmatic vs Ideal, Surrogate vs. Hard Endpoints; Time it takes; Ethics; Control arms; Purpose; I cover it all here.
4.47 Malignant Book Club w/ Dr. Olivier Part 2 of 9
22 mars 2022 |
52 min
In this book club we discuss Chapters 2 and 3 of Malignant, covering Surrogates and their role in Oncology
4.46 - Cancer Monologue and Lecture #5 from VP's Class on How to Appraise Medical Literature
16 mars 2022 |
51 min
This is a brief monologue with Dr. Timothee Olivier, and the audio from a class I taught on RCTs-- when are they needed in biomedicine
4.45 - Malignant Book Club w/ Dr. Olivier Part 1 of 9
12 mars 2022 |
64 min
Here is the first of a 9 part series on Malignant Book Club with Timothee Olivier from Switzerland
We cover cost of drugs, and intro to cancer drug policy
4.44 - Cost Of Cancer Drugs - Basics In Cancer Drug Policy
4 mars 2022 |
44 min
I lecture on basics on cancer drug policy
4.43 - VKPrasad Lab Update Part 2 With Timothee Olivier
1 mars 2022 |
67 min
I am back with Timothee Olivier from Geneva Switzerland to discuss Part 2 of our laboratory work. Can oncologists criticize RCTs? We also announce our new series. A 9 week Malignant Bookclub
4.42 - Timothee Olivier, Geneva in the first Installment of VKPrasad Lab updates
24 februari 2022 |
66 min
Timothee Olivier from Geneva Hospital Switzerland joins me for the first in a series of episodes on updates from VKPrasad laboratory, where we discuss cancer drugs & policy & evidence
4.41 The Mask Debacle with Jacob Hale Russell
19 februari 2022 |
67 min
Jacob Hale Russell is back from Rutgers law to talk about his new piece in Tablet Magazine.
4.40 H Gilbert Welch - Melanoma Screening; Blood Based Cancer testing; Lung CA screening
28 januari 2022 |
63 min
A discussion about the excesses of testing with Gil Welch
4.39 Dr Zeb Jamrozik, ID ethicist, practicing doctor, great thinker
27 januari 2022 |
92 min
I am joined for my 4th conversation with Zeb. This is a far reaching conversation where we discuss mandates, vaccines, masking, and why evidence based medicine still has something to offer.
4.38 COVID-19: Boosters for Adults and Teens, Paul Offitt, Testing, Myocarditis, Campus Restrictions
21 januari 2022 |
132 min
We're back this week with a collection of monologues! We talk about a Paul Offitt quote, COVID boosters for adults and kids, COVID testing, whether this is a pandemic of the unvaccinated, myocarditis and pericarditis, college campus restrictions, and more!
STAT News Op-Ed: https://www.statnews.com/2021/12/23/at-a-time-when-the-u-s-needed-covid-19-dialogue-between-scientists-francis-collins-moved-to-shut-it-down/
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4.37 MEMOIR & The Emperor Has No Clothes (a Critique of Cancer Care) with Dr. Christopher Booth
6 januari 2022 |
57 min
Today we have a short discussion for you of the MEMOIR study, published in The Lancet Oncology: "Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study". We also have a special treat for you: a lecture Dr. Chris Booth of Queen's University, Kingston, Ontario, Canada recently gave titled "The Emperor Has No Clothes", a critique of the current state of cancer care.
MEMOIR: doi.org/10.1016/S1470-2045(21)00546-5
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4.36 Where Are We Now with COVID-19? with Dr. John Ioannidis
4 januari 2022 |
107 min
Today we have an in-depth, in-person interview with Dr. John Ioannidis of Stanford University. We ask him: where are we now with COVID-19?
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4.35 Omicron, Travel Bans, Masks, Vaccine Mandates with Dr. Zeb Jamrozik
31 december 2021 |
89 min
Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back again! We discuss Omicron, travel bans, masks, vaccine mandates, and more.
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4.34 ASH Lymphoma Updates: POLARIX, ZUMA 7, BELINDA w/ Papa Heme and DRG
24 december 2021 |
75 min
David Russler-Germain and Papa Heme join VP to discuss the hottest ASH lymphoma papers: POLARIX and 2 CAR-T trials (ZUMA-7 & BELINDA)
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4.33 Melanoma: Tebentafusp, Stage Migration, Adjuvant Therapy, Training with Dr. Adil Daud
22 december 2021 |
65 min
We have an in-person interview for you today! We sit down with Dr. Adil Daud of UCSF to talk all things melanoma. We cover Tebentafusp, nodal dissection, the Will Rogers phenomenon and the effect of stage migration on clinical trials as imaging advances, adjuvant vs I/O, academic training vs apprenticeship for budding oncologists, and more!
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4.32 Oral Azacitidine for AML and Nelarabine for T-ALL with Dr. Bernard Marini
3 december 2021 |
65 min
We're back with a hematology/oncology heavy episode! We talk about oral azacitidine for acute myeloid leukemia (AML) and nelarabine for T-cell acute lymphoblastic leukemia (T-ALL) with Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology and Associate Professor at University of Michigan Medicine.
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4.31 Neoadjuvant Radiation Therapy in Pancreatic Adenocarcinoma with Dr. William Hall
24 november 2021 |
55 min
Today we interview Dr. Bill Hall, Associate Professor of Radiation Oncology and Surgery at Medical College of Wisconsin, on his new paper out now in the Journal of Clinical Oncology titled "Value of Neoadjuvant Radiation Therapy in the Management of Pancreatic Adenocarcinoma".
Neoadjuvant: doi.org/10.1200/JCO.21.01220
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4.30 COVID in Children and the US FDA Vaccine Advisory Committee with Dr. Cody Meissner
22 november 2021 |
69 min
Today we interview Dr. Cody Meissner, Chief of the Division of Pediatric Infectious Disease and Professor of Pediatrics at Tufts University School of Medicine. Dr. Meissner is also a member of the US FDA Vaccine Advisory Committee. We talk about the affect of school closures on the health of children, the evidence base for COVID vaccine mandates in children, and the nuance surrounding all of it.
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4.29 Scientific and Ethical Failures of COVID-19 with Dr. Zeb Jamrozik
11 november 2021 |
73 min
Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back by popular demand! We talk about the failures, both scientific and ethical, of the COVID-19 pandemic.
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4.28 Calling Out Unethical Clinical Trials, Melflufen, and Academic Oncology with Dr. Aaron Goodman
6 november 2021 |
56 min
We're joined today by Dr. Aaron Goodman, a hematologist/oncologist at the University of California San Diego, to talk about calling out an unethical clinical trial, Melflufen, and academic oncology.
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4.27 Economics and Medicine with the Host of Freakonomics, M.D., Dr. Anupam Bapu Jena
29 oktober 2021 |
80 min
We're joined by Dr. Bapu Jena of Harvard Medical School to talk about his show, Freakonomics, M.D., and his career at the intersection of economics and medicine.
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4.26 Recent Kidney Cancer Trials, Unethical Cancer Clinical Trial, & CASSIOPEIA
28 oktober 2021 |
35 min
We have three topics for you today: We talk about our recent paper on the use of second-line immunotherapy in kidney cancer, the controversy over whether a cancer clinical trial was unethical, and the results of the randomized clinical trial CASSIOPEIA.
Kidney Cancer: doi.org/10.1001/jamanetworkopen.2021.24728
CASSIOPEIA doi.org/10.1016/S1470-2045(21)00428-9
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4.25 A Critique of COVID-19 Health Policy with Infectious Disease Ethicist Dr. Zeb Jamrozik
20 oktober 2021 |
73 min
Today we have an interview with Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford. We talk about COVID-19 health policy and where we went wrong, speaking specifically from the values framework of health, fairness, and freedom.
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4.24 COVID-19: Moderna booster, Myocarditis, Progressivism, Social Media, Masks, Tests, J&J booster
16 oktober 2021 |
107 min
We have a summary of our thoughts for you on recent news about COVID. We discuss the prospect of FDA authorization of a Moderna booster, 8 lessons for health policy in times of crisis, updates on myocarditis data from Israel and Europe, how our experiences with COVID warn us of the possible end to democracy, how progressivism is dead, why social media should not censor views, the CDC's new masking studies, the slogan "follow the science", weekly testing of vaccinated college students who don't have symptoms, the survival of science after COVID, and the question of requiring a booster to follow the Johnson & Johnson vaccine.
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4.23 Access to Cancer Medicines, Standard of Care in Oncology, and the Oncology Value Paradigm
15 oktober 2021 |
88 min
On today's episode we're joined by a number of special guests: Dr. Christopher Booth and Dr. Adam Fundytus of Queen's University in Kingston, Ontario, Dr. Manju Sengar of the Tata Memorial Centre, and Dr. Aaron Goodman of the University of California at San Diego. We talk about their new papers: "Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey", "Practicing on the edge of oncology: when standard of care feels uncomfortable", and "Has the Current Oncology Value Paradigm Forgotten Patients’ Time? Too Little of a Good Thing".
Cancer Medicines: doi.org/10.1016/S1470-2045(21)00463-0
Edge of Oncology: doi.org/10.1038/s41571-021-00550-9
Value Paradigm: doi.org/10.1001/jamaoncol.2021.3600
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4.22 Honoring Dr. Elilhu Estey and His Decades-Long Oncology Career
12 oktober 2021 |
78 min
On today's episode, in honor of him and in recognition of his passing, we have an old interview with Dr. Elihu Estey of the University of Washington on his 40 years of experience as an oncologist, the "Renaissance" of drugs for leukemia, and advice for trainees on how to approach career goals. This interview originally aired as episode 1.49. He will be missed.
4.21 Cognitive Errors in Medical Decision-Making with Dr. Daniel Morgan & COVID-19 Policy
22 september 2021 |
89 min
This week we take a break from #zercovid to give you another episode that's a deep dive into COVID-19. We start with an interview with epidemiologist and infectious disease expert Dr. Daniel Morgan of the University of Maryland School of Medicine; we talk about cognitive errors in medical decision-making and how it relates to COVID-19 health policy. After that, we have a series of thoughts for you on COVID vaccine mandates for schools, President Biden's vaccine plan, the FDA's vote on boosters, John Ioannidis' new paper on vaccinating students, the Pfizer results for vaccines in kids 5-11, and accepting that COVID is here to stay.
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4.20 Vaccinating Kids and College Students, Boosters, Outdoor Masking, Bangladesh RCT, & more!
14 september 2021 |
70 min
Today we take a brief break from our #zerocovid mantra to offer you our thoughts on current events. We cover a variety of topics, including: medical doctors in academia, cancelling conferences even for the vaccinated, masking 2-year-olds, equipoise, the CDC Georgia study, myocarditis, booster shots, outdoor masking at Duke, no more zero COVID in Australia, the Bangladesh cluster RCT on masks and its implications for kids in the USA, the resignation of two senior FDA officials, LA schools mandating vaccines, vaccinating college students, and more.
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4.19 Censoring: Not on Facebook, but in Kaplan-Meier Curves
8 september 2021 |
31 min
Today's episode is a lecture our host, Dr. Vinay Prasad of University of California San Francisco, gave recently on censoring patients in Kaplan-Meier plots.
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4.18 Dementia Interventions, Skills for Epidemiologists, & Aducanumab with Dr. Maria Glymour
1 september 2021 |
78 min
Today we're joined by social epidemiologist, Dr. Maria Glymour of UCSF. We talk about her work in studying public health interventions for dementia and how her experience in academia has led to her conviction in the necessity of rigorous, quantitative technical skills training for epidemiology PhD students. We touch on how to have a good idea, her advice for PhD applicants, and working in a soft money (grants) vs hard money environment. Finally, we discuss her idea for a stepped-wedge trial approach to evaluate the new Alzheimer's drug, aducanumab.
Aducanumab: https://sites.bu.edu/melodem/files/2021/07/Pragmatic-Study-Designs-to-Accelerate-Aducanumab-Evidence_Glymour.pdf
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4.17 RCTs for Cancer Drug Approval with Dr. Saroj Niraula & Myeloma Studies with Dr. Manni Mohyuddin
27 augusti 2021 |
59 min
We have two oncology conversations for you today. The first is with Dr. Saroj Niraula of the University of Manitoba, and together we discuss the necessity of randomized controlled trials for granting FDA approval of cancer drugs. The second is with Dr. Ghulam Rehman "Manni" Mohyuddin of the University of Utah on a variety of myeloma studies, including LIGHTHOUSE, OCEANS, and HORIZON.
Feasibility of RCTs: doi.org/10.1093/jncics/pkab061
RR of Alternative Treatments: doi.org/10.1002/ijc.33231
Study Time Reduction: doi.org/10.1001/jamainternmed.2018.8351
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4.16 Treating Lymphoma, Histiocytic Disorders, Learning by Teaching, & More! with Dr. Bita Fakhri
21 augusti 2021 |
65 min
Today we interview Dr. Bita Fakhri of UCSF on the current research behind treatments for lymphoma. We touch on CAR-T, ABVD, DA-EPOCH-R, and more. We also talk about histiocytic disorders, Dr. Fakhri's career in academia, and learning through teaching.
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4.15 #AllCOVID-19: the Tough Questions About Policies Concerning the Delta Variant of COVID-19
19 augusti 2021 |
42 min
Today we're compiling all our recent monologues on COVID-19. That's right -- we're taking a break from #zerocovid to give you an episode that's #allcovid! We cover a whole range of news and opinions covering the Delta variant. We give an evidence-based-medicine doctor's take on the question: Are RCTs necessary in the age of COVID19? We also talk about how the American Academy of Pediatrics (AAP) lost the narrative. We detail how America failed kids because the AAP, CDC, & the teachers unions all hate Trump more than they love kids. We cover vaccine boosters: are they justified? Is there enough evidence? We detail how to run a randomized controlled trial of a policy intervention. And, finally, we confront the New York Times opinion article "Actually, Wearing a Mask Can Help Your Child Learn". We confront the tough questions: Do children really need to see faces? Why do we even have faces?
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4.14 Evolution of GI Cancer Therapy, Editing JCO, Advice for Clinical Trialists with Dr. Alan Venook
11 augusti 2021 |
68 min
Today we interview Dr. Alan Venook of UCSF, a renowned expert in clinical trial design and gastrointestinal malignancies. We talk about the evolution of the treatment for colorectal cancer over the last few decades, starting with 5FU. We also discuss his time working as an editor for the Journal of Clinical Oncology and we talk about his advice for budding clinical trialists.
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4.13 Lessons from Publishing 300 Peer-Reviewed Papers & What Telemedicine Will Do to Cancer Care
6 augusti 2021 |
15 min
We have two short thinkpieces for you. The first is on the lessons that can be learned, or have been learned along the way, from publishing 300 peer-reviewed papers in medical/scientific journals. The second is on the recent publication with Jenny Gill out now in the International Journal of Cancer, titled "After COVID-19, telemedicine may be used in addition to usual care and not in lieu of: Implications for health systems".
Telemedicine: doi.org/10.1002/ijc.33752
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4.12 Real-World Survival Outcomes for Pertuzumab and T-DM1 with Dr. Josee-Lyne Ethier
3 augusti 2021 |
36 min
Today we interview Dr. Josee-Lyne Ethier of Queen's University in Kingston, Ontario, Canada on her new paper "Practice Patterns and Outcomes of Novel Targeted Agents for the Treatment of ERBB2-Positive Metastatic Breast Cancer", out now in JAMA Oncology. We talk about the real-world survival outcomes for pertuzumab and T-DM1, comparing these outcomes to the results of pivotal clinical trials CLEOPATRA and EMILIA.
Practice Patterns and Outcomes: doi.org/10.1001/jamaoncol.2021.2140
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4.11 CheckMate 274, PARADIGM-HF/Ernesto, POLO, & an AI Approach to Reducing Knee Pain
31 juli 2021 |
54 min
Today's episode is a compilation of a few short monologues. We provide an oncologist's evidence-based medicine perspective on four papers: CheckMate 274, adjuvant nivolumab in urothelial cancer; PARADIGM-HF/Entresto; the POLO trial, olaparib in pancreas cancer; and the paper "An algorithmic approach to reducing unexplained pain disparities in underserved populations".
CheckMate 274: doi.org/10.1056/NEJMoa2034442
PARADIGM-HF: doi.org/10.1056/nejmoa1409077
POLO: doi.org/10.1056/NEJMoa1903387
Knee pain: doi.org/10.1038/s41591-020-01192-7
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4.10 A Deep Dive into CheckMate 649 with Dr. Jeffrey Bien
28 juli 2021 |
59 min
Today we sit down (in person!) with Dr. Jeff Bien of Stanford University to break down all the details -- from the methods to the statistical analysis to the conclusions -- of the CheckMate 649 trial, which pitted first-line nivolumab plus chemotherapy against chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma.
CheckMate 649: doi.org/10.1016/S0140-6736(21)00797-2
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4.09 Problems with the VISION Trial & Stool Transplant Plus Nivo for Metastatic Melanoma
23 juli 2021 |
27 min
Today we have two short monologues for you on recent papers. The first, by popular request, is the problems with the VISION trial, which treated metastatic castration-resistant prostate cancer with lutetium-177–PSMA-617 (Lu-177–PSMA-617) radioligand therapy and standard of care. The second is on the paper recently published in Science titled "Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients".
Fecal transplant: doi.org/10.1126/science.abb5920
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4.08 Implications for the Fate of Accelerated Approval from the ODAC Votes of April 2021
16 juli 2021 |
12 min
In today's quick episode, we talk about our new paper out now in JAMA Network Open titled "The Oncologic Drugs Advisory Committee Votes of April 2021—Implications for the Fate of Accelerated Approval"
ODAC Votes: doi.org/10.1001/jamaoncol.2021.3046
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4.07 Questions from a Medical Student with Emma Greenstreet and Dr. Vinay Prasad
9 juli 2021 |
49 min
We have a reverse episode for you today! Emma Greenstreet, a second-year medical student at UCSF, interviews our usual host, Dr. Vinay Prasad on why and how he chose hematology/oncology as a specialty, engaging with criticism, mentorship, medical student rotations, choosing a research project, and urging doctors in academia to aim higher.
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4.06 CAR-T, Oncology RCTs, Social Media, Myeloma, and Career Decisions with Dr. Rahul Banerjee
8 juli 2021 |
92 min
We sat down in person with Dr. Rahul Banerjee, a BMT/CAR-T fellow at UCSF, to talk about all manner of topics including CAR-T, randomized trials in oncology (and, specifically, Dr. Banerjee's two recent papers out now), social media, treating Multiple Myeloma, and how people make career decisions.
What Oncologists Can Learn From COVID-19: doi.org/10.1038/s41571-020-00448-y
Are Observational, Real-World Studies Suitable: doi.org/10.1001/jamanetworkopen.2020.12119
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4.05 Exodus from Academia and the Regretful FDA Approval of Aducanumab with Dr. Ameet Sarpatwari
7 juli 2021 |
53 min
Today we are joined by Dr. Ameet Sarpatwari of Harvard Medical School to discuss how so many great minds in oncology are leaving cancer research in academia for industry. We also talk about the evidence (or lack thereof) behind the recent FDA approval of aducanumab to treat Alzheimer's disease.
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4.04 Treatment Algorithm for Follicular Lymphoma & Assessing RCTs
26 juni 2021 |
31 min
Today we have a short monologue for you on just a few topics: a treatment algorithm for follicular lymphoma and our host Dr. Prasad's new paper out now in the European Journal of Clinical Investigation: "Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?"
RCTs or Synthetic Control Arms?: doi.org/10.1111/eci.13580
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4.03 Multiple Myeloma, Productivity Metrics, and Field Changes in Oncology with Dr. Nina Shah
18 juni 2021 |
69 min
Today we're back with another real-life (non-virtual!) interview. We're joined by Dr. Nina Shah of UCSF to discuss her career and her work in mutiple myeloma as well as the complexities of advancing your career -- dealing with productivity metrics like the h-index or the Kardashian index, switching institutions, balancing work with your home life, adapting to the changing field of oncology, and more.
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4.02 The History of Breast Cancer Research and Treatment with Dr. George Sledge
15 juni 2021 |
104 min
Today we sit down with Dr. George Sledge of the Stanford University Medical Center to hear the story of his career and to discuss the history of breast cancer research and treatment.
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4.01 Highlights from the 2021 ASCO Annual Meeting
11 juni 2021 |
50 min
Today we're launching season 4 of Plenary Session! This season we're returning to our love of monologues. On today's episode we talk about highlights from the recent annual meeting of the American Society of Clinical Oncology.
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3.90 Redesigning Health Care, Overuse, Burnout, and COVID-19 Groupthink with Dr. Marty Makary
4 juni 2021 |
76 min
On today's episode, we interview Dr. Marty Makary of Johns Hopkins School of Medicine and Bloomberg School of Public Health on how he chose his path in medicine, how health care as it is in the United States needs to change, and how groupthink dominated COVID-19 health policy. We discuss a variety of topics from his research on overuse, the prevalence of burnout in healthcare professionals, silos in medicine, to patients' lawsuits against hospitals. We touch on his two books, the latter of which has a new edition coming out next month that addresses COVID-19: Unaccountable: What Hospitals Won't Tell You and How Transparency Can Revolutionize Health Care, and "The Price We Pay: What Broke American Health Care--and How to Fix It".
Unaccountable: https://www.bloomsbury.com/us/unaccountable-9781608198368/
The Price We Pay: https://www.bloomsbury.com/us/the-price-we-pay-9781635575910/
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3.89 How to Think About COVID-19 Policy with Rare Events and Declining Probabilities
3 juni 2021 |
28 min
Today we have a brief monologue for you on how to think about COVID-19 policy in the context of rare event and declining probabilities. We also touch on what to expect from season 4 of this podcast, as season 3 comes to an end.
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3.88 Behind the Scenes for the One-Year Anniversary of Malignant with Dr. Vinay Prasad
2 juni 2021 |
78 min
Today's episode is hosted by guest Logan Powell, an incoming medical student at the Texas A&M College of Medicine and creator of this podcast's show notes. He reverse interviews our usual host, Dr. Vinay Prasad, in honor of the one-year anniversary release of Dr. Prasad's book "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer". They explore a few behind-the-scenes stories.
Show notes: www.plenarysessionpodcast.com
Listen to Malignant with a free 30-day trial of Audible: www.audible.com/pd/B08864KFHW/?so…ACX0_195112_rh_us
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3.87 Round Table on Multiple Myeloma Initial Therapy, High Risk, and Maintenance
31 maj 2021 |
64 min
Today we try something new. We're joined by five esteemed multiple myeloma experts for a back-and-forth round table discussion on the disease, including initial therapy, high risk, and maintenance. Our guests are Dr. Raj Chakraborty of Columbia University, Dr. Sam Rubinstein of the University of North Carolina Chapel Hill, Dr. Manni Mohyuddin of the University of Utah, Dr. Ben Derman of the University of Chicago, and Dr. Kevin Knopf of Highland Hospital.
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3.86 Lenvatinib plus Pembrolizumab or Everolimus for Advanced RCC with Dr. Karine Tawagi
28 maj 2021 |
35 min
Today we bring back our popular Journal Club with a Fellow segment. We're joined by Dr. Karine Tawagi of the Oschner Clinic in Louisiana to discuss the CLEAR trial: "Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma" as published in the New England Journal of Medicine.
CLEAR: doi.org/10.1056/NEJMoa2035716
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3.85 Med-Psych, Palliative Care, and Respect for Autonomy and Dignity with Dr. Joshua Briscoe
27 maj 2021 |
47 min
Our guest today is Dr. Joshua Briscoe of Duke University. We discuss Med-Psych (a joint internal medicine and psychiatry residency) and how it and palliative care connect to the human side to medicine: providing the care for quality of life and dignity that patients actually need, from comfortable bedding to physician-assisted suicide.
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3.84 DLBCL, Bad Cancer Drugs and Bad Twitter Users with Dr. Aaron Goodman
26 maj 2021 |
72 min
We're joined today by Dr. Aaron Goodman, a hematologist/oncologist at the University of California San Diego, to discuss diffuse large B-cell lymphoma (DLBCL). We talk about bad cancer drugs and bad Twitter users.
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3.83 MetaResearch, Reproducibility, Expertise, & Early Career Researchers with Dr. Ioana Cristea
25 maj 2021 |
77 min
Today we sit down with Dr. Ioana Cristea of the University of Pavia, Italy and the Meta-Research Innovation Center at Stanford to discuss meta-research, reproducibility, and expertise. We also talk about our shared experiences as "early career researchers" (ECRs), also known as Early Stage Investigators, a term coined by the National Institutes of Health to describe researchers who earned their last research degree less than 10 years ago.
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3.82 Classical Hematology Chat on CVT and VITT with Drs. Sven Olson and Joseph Shatzel
24 maj 2021 |
46 min
Today we host a Classical Hematology Chat on thrombosis associated with COVID-19 vaccines. We're joined by Drs. Sven Olson and Joseph Shatzel of Oregon Health & Science University as we talk about cerebral venous thrombosis (CVT) and vaccine-induced immune thrombotic thrombocytopenia (VITT).
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3.81 Impact of COVID-19 on Sociology, Politics, and Democracy with Genève Campbell
21 maj 2021 |
77 min
Today we are joined by Genève Campbell, scholar of democracy and government, as we discuss sociology and politics in the context of COVID-19.
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3.80 ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) with Drs. Bishal Gyawali and Nathan Cherny
20 maj 2021 |
54 min
Today we sit down with Dr. Bishal Gyawali of Queen's University in Kingston, Ontario, Canada and with Dr. Nathan Cherny of Shaare Zedek Medical Center in Jerusalem, Israel to talk about the European Society of Medical Oncology (ESMO) and the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS), which aims to improve cancer therapy decision-making.
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3.79 Sweden's Stance on COVID-19, Hydroxychloroquine, Schools, & Mask Data with Dr. Cathrine Axfors
19 maj 2021 |
69 min
On today's episode, we sit down with Dr. Cathrine Axfors of the Meta-Research Innovation Center at Stanford (METRICS) to discuss how Sweden responded to COVID-19 and the nation's attention to what policies would be sustainable. We also touch on her paper "Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials" as well as school closures, data to support mask policies, and more!
Hydroxychloroquine: doi.org/10.1038/s41467-021-22446-z
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3.78 Astronomy, Being a Scientist, and the Culture of the Academy with Dr. Avi Loeb
18 maj 2021 |
61 min
Today we talk with Dr. Avi Loeb of the Harvard-Smithsonian Center for Astrophysics about astronomy and the culture of the academy, as well as diving into topics discussed in his new book Extraterrestrial: The First Sign of Intelligent Life Beyond Earth.
Extraterrestrial: https://www.hmhbooks.com/shop/books/Extraterrestrial/9780358274551
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3.77 Reporting of Race in US FDA Registration Trials with Dr. Mark Lythgoe
17 maj 2021 |
26 min
Today we talk with Dr. Mark Lythgoe, a Clinical Research Fellow at Imperial College London, on his new paper titled "Race reporting and diversity in US food and drug administration (FDA) registration trials for prostate cancer; 2006-2020", out now in Prostate Cancer and Prostatic Diseases.
Race Reporting: doi.org/10.1038/s41391-021-00361-0
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3.76 COVID-19 Transmission in Schools with Dr. Christopher Whaley and Dr. Neeraj Sood
14 maj 2021 |
43 min
On today's episode, we invite Dr. Chris Whaley of RAND and Dr. Neeraj Sood of the USC Price School of Public Policy to discuss their new paper titled "Back to School: The Effect of School Visits During COVID-19 on COVID-19 Transmission", out now in the National Bureau of Economic Research.
Back to School: doi.org/10.3386/w28645
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3.75 All Things COVID-19 with Infectious Disease Professor Dr. Paul Edward Sax
14 maj 2021 |
83 min
Today our guest is Dr. Paul Edward Sax, Clinical Director of the Infectious Disease Clinic and Professor of Medicine at Harvard Medical School. We talk about all things COVID-19.
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3.74 Artificial Intelligence in Dermatology with Dr. Roxana Daneshjou
13 maj 2021 |
43 min
On today's episode, we interview Dr. Roxana Daneshjou, a clinical scholar in dermatology and postdoctoral research fellow at Stanford University. We talk about artificial intelligence in dermatology and beyond.
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3.73 CheckMate 577: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer
12 maj 2021 |
16 min
On today's episode, we have a short monologue for you on the recent CheckMate 577 study that was recently published in the New England Journal of Medicine. The title of the paper is "Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer".
CheckMate 577: doi.org/10.1056/NEJMoa2032125
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3.72 Industry Payments to US Physicians for Cancer Therapeutics with Dr. Daniel Meyers
11 maj 2021 |
48 min
Today we're joined by Dr. Daniel Meyers of the University of Calgary who's here to discuss his new paper out now in the Journal of Cancer Policy. It's titled "Industry payments to US physicians for cancer therapeutics: An analysis of the 2016–2018 open payments datasets".
Industry payments: doi.org/10.1016/j.jcpo.2021.100283
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3.71 How Research Influences Policy with Dr. Kirsten Bibbins-Domingo
5 maj 2021 |
91 min
Today we sit down with Dr. Kirsten Bibbins-Domingo, Chair of the Department of Epidemiology and Biostatistics and the inaugural Vice Dean for Population Health and Health Equity in the UCSF School of Medicine. We talk about mentorship throughout a career, the unique value of epidemiology and biostatistics, finding passion in your work, disparities in healthcare during the COVID-19 pandemic, and more.
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3.70 The Motivation We Need to Reach the End of the COVID-19 Pandemic with Dr. Monica Gandhi
30 april 2021 |
31 min
Today we sit down with Dr. Monica Gandhi, Associate Division Chief of the Division of HIV, Infectious Diseases, and Global Medicine at UCSF/ San Francisco General Hospital, and medical director of the HIV Clinic at SFGH. We talk about ending COVID-19 pandemic restrictions, vaccination boosters, and more. She gives us the motivation we all need right now.
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3.69 Reporting of Postprotocol Therapies in Multiple Myeloma with Dr. Ghulam Rehman Mohyuddin
29 april 2021 |
40 min
Today we talk with Dr. Manni Mohyuddin of Kansas University Medical Center on his new paper out now in JAMA Network Open titled "Reporting of Postprotocol Therapies and Attrition in Multiple Myeloma Randomized Clinical Trials: A Systematic Review".
Postprotocol Therapies: doi.org/10.1001/jamanetworkopen.2021.8084
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3.68 A Career in Academic Medicine & Challenges of 2021 with Former Harvard Dean, Dr. Jeffrey Flier
29 april 2021 |
71 min
On today's episode, we interview Dr. Jeffrey Flier, an esteemed endocrinologist and physician researcher who was Dean of the Faculty of Medicine at Harvard University for nine years (2007-2016). We talk about his career in academic medicine as well as the challenges of 2021.
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3.67 Thoughts on PhD Programs and Idecabtagene Vicleucel with Dr. David Russler-Germain
23 april 2021 |
62 min
Today we bring back popular guest Dr. David Russler-Germain, a Hematology/Oncology Fellow at the Washington University School of Medicine in St. Louis, to discuss his thoughts on PhD programs (in response to a listener question) as well as his take on Idecabtagene vicleucel for multiple myeloma.
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3.66 COVID-19 Policies and Progressing Past Disagreement with Dr. Martin Kulldorff
16 april 2021 |
66 min
Today we talk with Dr. Martin Kulldorff, a Professor of Medicine at Harvard Medical School and Brigham and Women's Hospital, about COVID-19 health policy and about disagreement.
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3.65 Banning Books, Social Media, & Medical Education with Dr. Adam Cifu
14 april 2021 |
62 min
Today we bring back popular guest Dr. Adam Cifu, a Professor of Medicine at the University of Chicago, to talk about the idea of banning books. the power of social media, and the current state of medical education.
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3.64 A Legal and Philosophical View on COVID-19 with Samantha Godwin
12 april 2021 |
57 min
Today we are joined by Samantha Godwin, a Resident Fellow for the Information Society Project at Yale Law School, to discuss COVID-19 health policy from a legal and philosophical perspective.
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3.63 The Medical Scientist Training Program with Dr. David Russler-Germain
8 april 2021 |
62 min
Today we talk again with Dr. David Russler-Germain, a Hematology/Oncology Fellow at the Washington University School of Medicine in St. Louis, this time on the Medical Scientist Training Program (MSTP).
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3.62 COVID-19 Transmission, Vaccines, & Olaparib with Dr. Tom Beer
8 april 2021 |
35 min
Today we interview Dr. Tom Beer, the Deputy Director of the Oregon Health & Science University Knight Cancer Institute, about COVID-19 transmission, policy, and vaccines. We also talk about olaparib.
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3.61 The Neuroscience and Psychology of Recreational Drug Use in Adults with Dr. Carl Hart
6 april 2021 |
46 min
Today we are joined by guest Dr. Carl Hart, a behavioral neuroscientist and Professor of Psychology at Columbia University. We discuss his research, his philosophies, and his new book "Drug Use for Grown-Ups."
Drug Use for Grown-Ups: https://www.penguinrandomhouse.com/books/534657/drug-use-for-grown-ups-by-dr-carl-l-hart/
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3.60 Drugs for Acute Lymphoblastic Leukemia with Dr. Bernard Marini
31 mars 2021 |
82 min
Today we bring back popular guest Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology at University of Michigan Medicine, to discuss treatment of Acute Lymphoblastic Leukemia (ALL).
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3.59 Genetic Alterations Linked to SARS-CoV-2 Acquisition and Bad Outcomes with Dr. Nathan Pearson
30 mars 2021 |
28 min
Today we are joined by genomicist Dr. Nathan Pearson, founder of Root (rootdeep.com), to discuss which genetic alterations in the host predispose to SARS-CoV-2 acquisition and bad outcomes.
Gift of Life: www.giftoflife.org/page/content/covid19faq
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3.58 Expertise and Disinformation with Jacob Hale Russell
26 mars 2021 |
74 min
Today we bring back popular guest Jacob Hale Russell, an Associate Professor of Law at Rutgers Law School, for a discussion on expertise, disinformation, and intellectual disagreement.
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3.57 Career Paths and Evolution of the Oncology Randomized Clinical Trial with Dr. Christopher Booth
26 mars 2021 |
64 min
On today's episode we talk with popular guest Dr. Chris Booth of Queen's University in Kingston, Ontario, Canada about mapping out a career path after medical school and about his new paper out now in JAMA Oncology titled "Evolution of the Randomized Clinical Trial in the Era of Precision Oncology".
The Oncology RCT: doi.org/10.1001/jamaoncol.2021.0379
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3.56 Quality of Control Groups in RCTs of Multiple Myeloma with Dr. Ghulam Rehman Mohyuddin
25 mars 2021 |
32 min
Today we interview Dr. Ghulam Rehman Mohyuddin of Kansas University Medical Center on his new paper out now in The Lancet Haematology titled "Quality of control groups in randomised trials of multiple myeloma enrolling in the USA: a systematic review".
Control Groups: doi.org/10.1016/S2352-3026(21)00024-7
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3.55 Equity in Vaccine Distribution, Cancel Culture, and Zero COVID-19 with Dr. Matthew Smith
24 mars 2021 |
82 min
Today we sit down with Dr. Matthew Smith, an associate professor in the Northeastern University Department of Philosophy and Religion, to discuss the morality and philosophical backbone behind COVID-19 vaccine distribution and how we should define equity; cancel culture and its historical longevity; and the impossibility (at least in the USA) of Zero COVID-19.
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3.54 The Passing of Dr. José Baselga
23 mars 2021 |
16 min
For today's episode we have a short monologue in remembrance of famed cancer researcher Dr. José Baselga.
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3.53 Updates on COVID-19 and Looking Back Over the Last Year with Dr. Aaron Richterman
19 mars 2021 |
82 min
Today we interview Dr. Aaron Richterman, an infectious disease specialist at Penn Medicine. We talk about updates on all things COVID-19 and we look back at how treatments, risk assessment, and behavior have changed.
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3.52 Medicine, Leadership, SARS-CoV-2, and Social Media with Dr. Bob Wachter
14 mars 2021 |
74 min
Today we interview Dr. Bob Wachter, the Chair of the Department of Medicine at University of California San Francisco. We talk about a wide range of topics including medicine, leadership, SARS-CoV-2, and social media.
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3.51 COVID-19 Modeling with Youyang Gu
12 mars 2021 |
56 min
On today's episode we interview Youyang Gu, an independent data scientist who created some of the most models of the COVID-19 pandemic. He talks us through how he made the projections. His work is available on his website: https://covid19-projections.com/
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3.50 Evildoer Marty Makary [SHORT]
11 mars 2021 |
11 min
On today's SHORT episode, we talk about censorship, Facebook, Twitter, and the "evildoer" Dr. Marty Makary.
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3.49 The Role of Government in Public Health and in COVID-19 Policy with Dr. Robert Freudenthal
10 mars 2021 |
63 min
Today we interview Dr. Robert Freudenthal, a psychiatrist in training at Barnet Enfield and Haringey Mental Health Trust in London, UK. We talk abut the power of the state and its role in public health policy. We focus specifically on how governments worldwide have responded to the COVID-19 pandemic, from extreme lockdowns to harm reduction advisories. We discuss how policy can be medical overreach as well as how it interplays with the criminal justice system and racial and class inequities. Finally, we discuss censorship and the need for trust and honesty in messaging.
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3.48 The Predictive Value of High Tumor Mutational Burden with Dr. Luc Morris
6 mars 2021 |
61 min
Today we interview Dr. Luc Morris of Memorial Sloan Kettering Cancer Center on his new paper out now in JAMA Oncology titled "Response Rates to Anti-PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase".
Response Rates: doi.org/10.1001/jamaoncol.2020.7684
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3.47 COVID-19 Vaccine Results, Messaging on a Patient Level, & Schools with Dr. Monica Gandhi
3 mars 2021 |
57 min
Today we interview Dr. Monica Gandhi, Associate Division Chief of the Division of HIV, Infectious Diseases, and Global Medicine at UCSF/ San Francisco General Hospital, and medical director of the HIV Clinic at SFGH, on COVID-19 interventions. We talk about results from the vaccine studies and how vaccination is perceived by the public. We talk about her new paper out now in The Lancet Infectious Disease on the importance of non-pharmaceutical interventions (masking, social distancing, ventilation, hand-washing) in controlling COVID-19. We also talk about the stark difference between messaging created from the point of view of an epidemiologist vs the public health messaging that frontline health care workers deliver directly to patients. We end the interview by talking about schools and the need to re-open them.
Importance of non-pharmaceutical interventions: doi.org/10.1016/S1473-3099(20)30982-8
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3.46 COVID-19 Risk, Cases, and Transmission in K-12 Schools with Dr. Tracy Høeg
27 februari 2021 |
47 min
Today we interview Dr. Tracy Høeg on her new paper and her ongoing research into COVID-19 transmission in K-12 schools in Wisconsin, USA. Dr. Høeg is an epidemiologist and an interventional sports and medicine spine specialist at Northern California Orthopaedic Associates. Her paper is titled "COVID-19 Cases and Transmission in 17 K-12 Schools - Wood County, Wisconsin, August 31-November 29, 2020" and is published in the CDC's Morbidity and Mortality Weekly Report.
Cases in K-12 Schools: doi.org/10.15585/mmwr.mm7004e3
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3.45 USMLE Steps, Residency Match, & M.D. vs D.O. with Dr. Bryan Carmody
24 februari 2021 |
88 min
On today's episode we interview Dr. Bryan Carmody, commonly known as the Sheriff of Sodium. He's a pediatric nephrologist at Children's Hospital of the King's Daughters in Virginia. We talk with him about the USMLE Steps (Step 1, Step 2, and Step 2 CS), their usefulness, their origins, and how to reform them. We also break down and discuss the inner workings of residency matching and the M.D. and D.O. designations.
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3.44 The Role of Philosophy, COVID-19 Policy, and COVID-19 Exceptionalism with Dr. Alex John London
17 februari 2021 |
78 min
Today we sit down with Dr. Alex John London, the Clara L. West Professor of Ethics and Philosophy and Director of the Center for Ethics and Policy at Carnegie Mellon University, to discuss the role of philosophy, COVID-19 exceptionalism, and various aspects of COVID-19 health policy including masking, vaccination, and schools.
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3.43 Reviewing the Beat AML Master Trial
15 februari 2021 |
27 min
On today’s episode we review the findings of the Beat AML study as published in Nature Medicine in an article titled “Precision medicine treatment in acute myeloid leukemia using prospective genomic profiling: feasibility and preliminary efficacy of the Beat AML Master Trial”.
Beat AML: doi.org/10.1038/s41591-020-1089-8
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3.42 Overdiagnosis and Cutaneous Melanoma Diagnoses with Dr. Adewole Adamson and Dr. Benjamin Mazer
10 februari 2021 |
66 min
For today's episode, we sit down with Drs. Ade Adamson of the University of Texas at Austin Dell Medical School and Ben Mazer of Johns Hopkins Hospital to discuss their new paper out now in the New England Journal of Medicine titled "The Rapid Rise in Cutaneous Melanoma Diagnoses". It's one of the best papers you'll read all year.
Melanoma Diagnoses: doi.org/10.1056/NEJMsb2019760
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3.41 Building a Meta-Research Career and Constructing COVID-19 Health Policy with Dr. John Ioannidis
7 februari 2021 |
119 min
For today's special episode, we sat down with Dr. John Ioannidis of Stanford University for an outdoor in-person interview. We take a deep dive into his work from 2000 all the way up to present day: his career from 2000 to 2010, his move to Stanford, and his work on COVID-19. We take a deep dive into his work on COVID-19: IFR, shielding ratio, the question of whether lockdown works, opening schools, and what public health policy should be.
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3.40 COVID-19 Vaccines, Origin of SARS-CoV-2, and Pandemic Mitigation with Prof Francois Balloux
5 februari 2021 |
57 min
On today's episode we're joined by geneticist Dr. Francois Balloux, the Director of the University College London Genetics Institute and professor of computational systems biology, on pandemic mitigation, SARS-CoV-2 variants, how news and social media amplify fear over fact, opening schools, lethality and risk, the origin of SARS-CoV-2, COVID-19 vaccine efficacy and vaccine escape, and more!
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3.39 Public Health Messaging on COVID-19 with Drs. Julia Marcus and Stefan Baral
4 februari 2021 |
69 min
On today's episode we feature an in-depth interview with Dr. Julia Marcus (Associate Professor at Harvard Medical School) and Dr. Stefan Baral (Associate Professor at Johns Hopkins Bloomberg School of Public Health), two infectious disease epidemiologists, on public health messaging around COVID-19 -- what we're getting right and where we're going terribly wrong.
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3.38 Oncology During COVID-19 & RCTs from Low- vs High-Income Countries with Dr. Christopher Booth
29 januari 2021 |
56 min
On today's episode we sit down with Dr. Chris Booth of Queen's University in Kingston, Ontario, Canada to discuss his new paper out now in JAMA Oncology titled "An Analysis of Contemporary Oncology Randomized Clinical Trials From Low/Middle-Income vs High-Income Countries". We also talk about how COVID-19 has affected oncology research. We touch, too, on the topic of evaluating how you spend your time and prioritizing your research.
Contemporary Oncology RCTs: doi.org/10.1001/jamaoncol.2020.7478
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3.37 Skepticism, COVID-19, and Debating Science in the Era of Trade-Offs with Jacob Hale Russell
27 januari 2021 |
93 min
On today's episode we are joined by Jacob Hale Russell, an Associate Professor of Law at Rutgers Law School. We discuss his forthcoming book on skepticism, elites, and expertise, as well as his article out now on StatNews about the myth of COVID-19 denial. We talk about anti-intellectualism and how science ought to be debated in the era of trade-offs and COVID-19.
Straw Man of Pandemic Denial: www.statnews.com/2020/12/23/put-straw-man-pandemic-denial-out-of-its-misery/comment-page-1/
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3.36 Sustainable Ex-Vivo Seafood with Dr. Arye Elfenbein
22 januari 2021 |
47 min
On today's episode we sit down with Dr. Arye Elfenbein, a cardiologist and "doctorpreneur " to interview him on the bio-tech company he recently co-founded: Wildtype. Wildtype manufactures ex-vivo fish meat for human consumption in fulfillment of their mission to create the cleanest, most sustainable seafood.
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3.35 The Secrets of Vermont in Taming the COVID-19 Pandemic with Anne Sosin
20 januari 2021 |
36 min
Today we interview Anne Sosin of Dartmouth College on public health policy in Vermont and how the state has uniquely tamed the COVID-19 pandemic.
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3.34 COVID-19 From a Philosopher's Point of View with Dr. Matthew Smith
15 januari 2021 |
68 min
Today we sit down with Dr. Matthew Smith, an associate professor in the Northeastern University Department of Philosophy and Religion, for a far-ranging discussion on COVID-19 from a philosopher's point of view.
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3.33 Hematologic Malignancies and Transplantation with Dr. Aaron Goodman
12 januari 2021 |
48 min
Today we are joined by Dr. Aaron Goodman, an Assistant Clinical Professor at the University of California San Diego, who talks with us about hematologic malignancies, transplantation, and our new paper out now in Blood titled "Persistent Challenges with Treating Multiple Myeloma Early".
Persistent Challenges: doi.org/10.1182/blood.2020009752
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3.32 Publishing Original Thought in Medical Journals with Dr. Stephen Bradley
8 januari 2021 |
52 min
Today we talk with Dr. Stephen Bradley, a General Practitioner and Clinical Research Fellow at the University of Leeds, on publishing in medical journals -- peer review, editorial practices, anti-intellectualism, and more!
Notes on Nationalism: www.orwellfoundation.com/the-orwell-foundation/orwell/essays-and-other-works/notes-on-nationalism/
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3.31 Random Thoughts on Visiting Hospital Patients During COVID-19 and Norman Wang's Lawsuit
6 januari 2021 |
41 min
Today we have for you an episode of random thoughts. We talk over the ramifications of the strict COVID-19 policy that prevents people from visiting their dying loved ones in the hospital. We also talk more about Norman Wang and his surrounding controversy given the recent lawsuit the Center for Individual Rights has filed against the University of Pittsburgh on his behalf.
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3.30 Benefit and Risk of SpaceOAR with Dr. William Hall
5 januari 2021 |
41 min
On today's episode we interview Dr. Bill Hall, Associate Professor of Radiation Oncology and Surgery at Medical College of Wisconsin, on our new paper out now in The Lancet Oncology titled "Considering benefit and risk before routinely recommending SpaceOAR".
SpaceOAR: doi.org/10.1016/S1470-2045(20)30639-2
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3.29 Censorship in Medicine with Jonathan Darrow
31 december 2020 |
62 min
On today's episode we discuss censorship in medicine in all its forms with legal expert Jonathan Darrow, an Assistant Professor at Harvard Medical School.
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3.28 Exploring the History of Medicine with Dr. Adam Rodman, host of Bedside Rounds
21 december 2020 |
74 min
On today's episode we talk podcasting and the history of medicine with Dr. Adam Rodman, the creator and host of the wildly popular podcast Bedside Rounds, and a hospitalist at the Beth Israel Deaconess Medical Center.
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3.27 All Recent Acute Myeloid Leukemia Drugs with Dr. Bernard Marini
16 december 2020 |
57 min
On today's episode we discuss all the new drugs for acute myeloid leukemia with Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology at University of Michigan Medicine.
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3.26 The Importance of Debate and Dialogue with Dr. Saurabh Jha
15 december 2020 |
58 min
Today's episode is an interview with Dr. Saurabh Jha, an Associate Professor of Radiology at the Hospital of the University of Pennsylvania, on the importance of debate and dialogue both historically and in today's modern context.
This is the second episode in our experiment in breaking our content up into bite-sized, single-topic episodes. What do you think? Do you prefer a shorter, single-focus episode, or do you prefer our old format?
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3.25 Public Health Policy on the Risk of COVID-19 in Children with Dr. Alasdair Munro
12 december 2020 |
54 min
Now that we are nine months into the COVID-19 pandemic in the United States, we invite Dr. Alasdair Munro, a pediatrics infectious disease expert, back on to the show to discuss recent developments in public health policy concerning the spread of COVID-19, the risk of it, and children. We also talk about the rigorously policed echo chamber of Twitter, specifically #medtwitter, and finding an audience for controversial opinions.
This week is also the start of an experiment in breaking our content up into bite-sized, single-topic episodes. What do you think? Do you prefer a shorter, single-focus episode, or do you prefer our old format?
Evidence summary of pediatric COVID-19: https://dontforgetthebubbles.com/evidence-summary-paediatric-covid-19-literature/
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3.24 KEYNOTE-177 & Mathematic Models for Fighting COVID-19 with Dr. Wesley Pegden
4 december 2020 |
76 min
This week we return to our roots of oncology and dissect the recent results from KEYNOTE-177. We also have an in-depth interview with mathematician Dr. Wes Pegden of Carnegie Mellon University on a mathematical approach to the COVID-19 pandemic.
KEYNOTE-177: doi.org/0.1056/NEJMoa2017699
COVID-19 Mathematical Model: https://math.cmu.edu/~wes/covid.html
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3.23 Capturing Your Audience with Dr. Zubin "ZDoggMD" Damania & JAVELIN 100 with Dr. Karine Tawagi
26 november 2020 |
70 min
We have a short and sweet episode for you this week -- no monologue, just two deep-dives with two stellar guests. Our first interview is with Dr. Zubin Damania (known as ZDoggMD) and we cover everything from making original music to the artistry of professional oratory to the pain of electronic health records. Our second interview is a return to our popular segment Journal Club with a Fellow: We invite on Dr. Karine Tawagi of the Oschner Clinic in Louisiana to discuss the JAVELIN 100 study.
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3.22 New Podcast, Opening Schools with Dr. Vladimir Kogan, Virtual Learning with Dr. Carycruz Bueno
21 november 2020 |
186 min
Our first guests this week are Drs. Adam Cifu and Scott Stern and are on to discuss their new podcast Symptom to Diagnosis -- based on their book of the same name -- about clinical reasoning. Next we bring back political scientist Dr. Vlad Kogan (from episode 3.13) to discuss the need to re-open schools in the context of rising COVID-19 cases and a changing political landscape. Finally we interview Dr. Carycruz Bueno on her critical research into the harms of fully virtual schooling.
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3.21 Affirmative Action with Leah Litman, Cost Implications with Dr. DeMartino, & Dr. John Mandrola
13 november 2020 |
184 min
First up this week we interview constitutional law scholar Leah Litman, an Assistant Professor of Law at the University of Michigan, on Dr. Norman Wang and the intricacies of the laws on affirmative action. Next, we talk with Dr. Patrick DeMartino, a pediatric hematology/oncology fellow at Oregon Health & Science University, on his new paper out now in JAMA Internal Medicine: "Potential Cost Implications for All US Food and Drug Administration Oncology Drug Approvals in 2018". Finally, we sit down with Dr. John Mandrola for an in-depth discussion on the intersection of medicine, politics, and advocacy.
Cost Implications: doi.org/10.1001/jamainternmed.2020.5921
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3.20 Public Health Messaging, COVID-19 in the U.S. Northeast, Journal Club with a Fellow
7 november 2020 |
183 min
We have a multitude of interviews for you this week. We start by interviewing Dr. Julia Marcus of the Harvard Medical School and Harvard Pilgrim Health Care Institute on messaging around public health interventions during the COVID-19 pandemic. We continue talking about COVID-19 with Anne Sosin and Dr. Elizabeth Carpenter-Song, both of Dartmouth College. They join us on the podcast to discuss how the Northeast region of the United States has uniquely handled COVID-19. Finally, we bring back the Journal Club with a Fellow segment and interview Dr. David Russler-Germain of Washington University School of Medicine in St. Louis on a new paper out now in The Lancet on CAR T-cell therapy in DLBCL: TRANSCEND NHL 001.
TRANSCEND NHL 001: doi.org/10.1016/S0140-6736(20)31366-0
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3.19 COVID-19 and the AIDS Pandemics with Dr. Monica Gandhi & Classical Hematology Chat
30 oktober 2020 |
102 min
We talk this week with Dr. Monica Gandhi, Associate Division Chief of the Division of HIV, Infectious Diseases, and Global Medicine at UCSF/ San Francisco General Hospital, and medical director of the HIV Clinic at SFGH. Speaking from decades of experience treating HIV/AIDS patients, she gives us her take on the public health policies enacted in response to the COVID-19 pandemic. We then conclude this week's episode with a Classical Hematology Chat with Dr. Sven Olson of Oregon Health & Science University.
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3.18 Social Media and News with Dr. Benjamin Mazer & Caplacizumab for TTP with Dr. Tem Bendapudi
23 oktober 2020 |
131 min
This week we have two fantastic interviews for you: The first is with Dr. Ben Mazer on the interplay between social media and news; the second is with Dr. Tem Bendapudi on whether Caplacizumab should be the standard of care for thrombotic thrombocytopenic purpura (TTP).
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3.17 COVID-19 and Schools in Norway with Dr. Atle Fretheim & Cancer Biology with Dr. Anthony Letai
16 oktober 2020 |
156 min
This week we sit down virtually with Dr. Atle Fretheim, Research Director of the Norwegian Institute of Public Health, to talk about how Norway has responded to the COVID-19 crisis - specifically, how they've handled it when it comes to public schools. We also have an interview with Dr. Anthony "Tony" Letai of the Dana Farber Cancer Center on cancer biology.
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3.16 Non-Drug Interventions with Dr. Margaret McCartney & Cancer Biology with Dr. Jason Sheltzer
9 oktober 2020 |
144 min
We start this week's episode off with a monologue covering a few current events, notably the recent editorial on the COVID-19 pandemic in the USA published by the New England Journal of Medicine titled "Dying in a Leadership Vacuum". From there we interview Dr. Margaret McCartney on her recent opinion piece in the BMJ titled "We need better evidence on non-drug interventions for covid-19"; we talk about masks, schools, the need for randomized trials, and more. Finally, we interview Dr. Jason Sheltzer on his recent papers on cancer biology and the implications of his findings on clinical medicine.
NEJM editorial: doi.org/10.1056/NEJMe2029812
Non-Drug Interventions: https://blogs.bmj.com/bmj/2020/08/28/margaret-mccartney-we-need-better-evidence-on-non-drug-interventions-for-covid-19/
Dr. Sheltzer's research: https://www.sheltzerlab.org/research
You can reach Dr. Sheltzer at sheltzer at cshl dot edu.
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3.15 COVID-19 in Children with Dr. Alasdair Munro & Pandemic Public Health with Dr. Stefan Baral
6 oktober 2020 |
119 min
We start this week's episode by interviewing Dr. Alasdair Munro, a pediatrics infectious disease expert, on the risk of spread of COVID-19 in children and through schools. We end with an interview with Dr. Stefan Baral, a field epidemiologist studying COVID-19, on the nature of public health during a global pandemic.
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3.14 COVID-19 with Dr. John Ioannidis & Trial Eligibility with Dr. Mary-Elizabeth Percival
3 oktober 2020 |
161 min
This week we have a two-hour-long, far-ranging interview with Dr. John Ioannidis of Stanford University on, broadly, meta-research and COVID-19 - including his recent controversies. We end the episode with an interview with Dr. Mary-Elizabeth Percival of the University of Washington on her new paper out now in Haematologica: "Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility".
High-Grade Myeloid Neoplasms: doi.org/10.3324/haematol.2020.254938
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3.13 COVID-19 and Schools, COVID-19 and Scott Atlas, and COVID-19 Policy
25 september 2020 |
164 min
This week's episode is all about COVID-19. We discuss general COVID-19 health policy and how spread of SARS-CoV-2 has been managed and should be managed; we discuss whether or not schools should be re-opened; and we discuss Dr. Scott Atlas's views. Our special guests are political scientist Dr. Vladimir Kogan, epidemiologist Dr. Daniel Morgan, and health economist Dr. Jay Bhattacharya.
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3.12 TMPRSS2, Cancer Imaging with Drs. Becker and Woo, Clinical Epidemiology with Dr. Thomas Newman
19 september 2020 |
156 min
We start this week's episode by critically examining the new paper titled "Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2)" and asking, is it racist? After that, we discuss advances in prostate cancer imaging with two imaging specialists from Memorial Sloan Kettering Cancer Center, Drs. Anton Becker and Sungmin Woo. Finally, we have a far-reaching interview with Dr. Thomas Newman of University of California San Francisco on clinical epidemiology and his new book Evidence-Based Diagnosis: An Introduction to Clinical Epidemiology.
TMPRSS2 and COVID-19: doi.org/10.1001/jama.2020.17386
PSMA PET-CT: doi.org/10.1016/S0140-6736(20)30314-7
Evidence-Based Diagnosis: https://www.cambridge.org/core/books/evidencebased-diagnosis/2807345CA679EC723697ED9C6D98A1AA
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3.11 Experts, Lockdown, Affirmative Action, & COVID-19 and Hearts with Professor Darrel Francis
12 september 2020 |
121 min
This week's monologue touches on the credibility of expert speakers, evaluating the COVID-19 lockdown as health policy, and the anti-affirmative action white paper written by Dr. Norman Wang and its controversy. In the second half of the episode we interview Professor Darrel Francis of Imperial College London on COVID-19 cardiology and Vascepa.
Anti-Affirmative Action: doi.org/10.1161/JAHA.120.015959
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3.10 Colon Cancer Screening, Vascepa Patent with Jonathan Darrow, PREVENTT with Dr. Toby Richards
5 september 2020 |
122 min
We have a number of topics for you this week! Among them, we cover the issue of colon cancer screening, especially in the light of Chadwick Boseman's recent passing. We interview Jonathan Darrow, an Assistant Professor at Harvard Medical School and faculty at Brigham and Women's Hospital, on patent litigation and the recent patent appeal for Vascepa. Finally, we interview Dr. Toby Richards, Professor of Surgery, on running clinical trials and, specifically, the results of his recent trial PREVENTT, out now in The Lancet.
PREVENTT: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31539-7/fulltext
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3.09 COVID-19 Risk, Financial Toxicity, & HALT-IT for Journal Club with Fellow Dr. Justine Ryu
29 augusti 2020 |
84 min
We start this week's episode by revisiting our discussion from last week on the PNAS study on racial concordance and birthing mortality. We continue our theme of critical appraisal by then tearing apart the recent paper published in BMJ titled "Two metres or one: what is the evidence for physical distancing in covid-19?" and its inability to support its colorful figures. We end the monologue with a few thoughts on academics who somehow author one paper a week. Finally, we turn to the last two segments of the show: the first is a discussion with Dr. Bishal Gyawali on his new paper out now in The Lancet Haematology titled "A survey in Nepalese patients with acute leukaemia: a starting point for defining financial toxicity of cancer care in low-income and middle-income countries" and the second is Journal Club with a Fellow, where we interview Dr. Justine Ryu on a paper published in The Lancet titled "Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial".
Racial Concordance: doi.org/10.1073/pnas.1913405117
COVID-19 Risk: doi.org/10.1136/bmj.m3223
Financial Toxicity: doi.org/10.1016/S2352-3026(20)30258-1
HALT-IT: doi.org/10.1016/S0140-6736(20)30848-5
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3.08 Racial Concordance in Birthing Mortality & HERO for Journal Club with Fellow Dr. Michael Burns
22 augusti 2020 |
93 min
This week we take a deep dive into two recently published studies, their surrounding controversy, and the broader implications. The first study was published in the journal Proceedings of the National Academy of Sciences of the USA and is titled "Physician–patient racial concordance and disparities in birthing mortality for newborns". The second was published in the New England Journal of Medicine and is titled "Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer", commonly known as the HERO trial. We discuss the HERO trial with Dr. Michael Burns of Northwestern as part of our new segment, Journal Club with a Fellow.
Racial Concordance: doi.org/10.1073/pnas.1913405117
HERO: doi.org/10.1056/NEJMoa2004325
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3.07 Lung Cancer Omics and Mortality, PPIs and COVID-19, & RECIST with Dr. Elizabeth Eisenhauer
15 augusti 2020 |
162 min
We have a lot in store for you this week! We start off by evaluating two recently published studies: "Evaluation of Omics-Based Strategies for the Management of Advanced Lung Cancer" (published in the Journal of Clinical Oncology: Oncology Practice) and "The Effect of Advances in Lung-Cancer Treatment on Population Mortality" (published in the New England Journal of Medicine). We talk a bit about tracking down the validity of a reference. We sit down with Dr. Branden Tarlow to discuss his thoughts on PPIs and COVID-19 acquisition. Finally, we conclude the episode by interviewing Dr. Elizabeth Eisenhauer of Queen's University in Kingston, Ontario, Canada on her career in cancer medicine.
Omics-Based Strategies: doi.org/10.1200/OP.20.00117
Population Mortality: doi.org/10.1056/NEJMoa1916623
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3.06 COVID-19 Vaccine Access, ADAURA, QOTW, & Journal Club with Fellow Dr. Karine Tawagi
7 augusti 2020 |
116 min
We start this week's episode by discussing access to investigational COVID-19 vaccines and recapping the problems with the ADAURA study. We transition from there to a Question of the Week with medical student Audrey Tran of Oregon Health & Science University. Finally, we introduce a new segment - Journal Club with a Fellow. In this inaugural segment we invite Dr. Karine Tawagi of the Oschner Clinic in Louisiana to the podcast to talk about IMbrave150.
IMbrave150: doi.org/10.1056/NEJMoa1915745
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3.05 LIVE! A Midsummer Night's Stream
30 juli 2020 |
76 min
This is the recording of a LIVE episode of Plenary Session in which Dr. Sue S Yom interviewed our host, Dr. Vinay Prasad, on how he built his career and how he conceptualizes his work. There's also a surprise guest near the end! Thank you to Dr. Kaleigh Doke, Dr. Brian Kavanagh, and the Virtual Visiting Professor Network for hosting this special episode.
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3.04 Listener Questions & MedTwitter and Risk-Benefit Profile of Ramucirumab with Dr. Bishal Gyawali
24 juli 2020 |
92 min
This week we respond to several questions sent in by listeners and then we interview Dr. Bishal Gyawali of Queen's University in Kingston, Ontario, Canada on MedTwitter, other recent events, and his recently published paper titled "Assessing the risk-benefit profile of ramucirumab in patients with advanced solid tumors: A meta-analysis of randomized controlled trials".
Ramucirumab: doi.org/10.1016/j.eclinm.2020.100458
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3.03 The National Lung Matrix Trial & the Major Flaw of the SPRINT Trial with Dr. Mark Friedberg
18 juli 2020 |
69 min
This week we discuss two major papers: The first was just recently released in Nature and it's titled "The National Lung Matrix Trial of personalized therapy in lung cancer". The second is a few years old, but exemplifies the importance of trial design. We discuss the second paper, titled "A Randomized Trial of Intensive versus Standard Blood-Pressure Control" and published in the New England Journal of Medicine with Dr. Mark Friedberg, a health policies and performance measurement researcher.
National Lung Matrix Trial: doi.org/10.1038/s41586-020-2481-8
SPRINT: doi.org/10.1056/NEJMoa1511939
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3.02 BONUS! National Clinician Scholars Program with Dr. Hilary Seligman
13 juli 2020 |
34 min
This week's BONUS episode is a discussion of the National Clinician Scholars Program with Dr. Hilary Seligman, the head of the program at University of California, San Francisco. The deadline for the application for the 2021-2023 cohort is July 15, 2020 (very soon!), though there may be some leniency due to the pandemic.
National Clinician Scholars Program: https://nationalcsp.org/
UCSF National Clinician Scholars Program: https://nationalscholars.ucsf.edu/
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3.01 Risk of COVID-19 Among Users of PPIs, Time to Treatment Initiation, & Dr. Lynora Saxinger
11 juli 2020 |
102 min
This week we discuss recent research (and the accompanying Twitter thread) on the risk of COVID-19 among users of proton pump inhibitors (PPIs). We also hold a philosophical discussion on the research surrounding time to treatment initiation (TTI) in cancer medicine. We end the episode with an interview with Dr. Lynora Saxinger of the University of Alberta, Edmonton, a specialist in Infectious Diseases.
PPIs and risk of COVID-19: https://twitter.com/BrennanSpiegel/status/1280527527325265920
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2.60 BONUS! Cancer Meta-Research 101: The Lay of the Land of Cancer Research
7 juli 2020 |
53 min
This BONUS episode is the recording of a lecture given on June 18, 2020 as part of Stanford's METRICS International Forum. METRICS stands for Meta-Research Innovation Center at Stanford University. This lecture is geared towards a broad audience and aims to provide a general sense of current cancer research. The lecture is titled "Cancer Meta-Research 101".
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Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew
2.59 The Best Doctor, Selinexor, & Annotation Services for NGS with Drs. Katsoulakis and Kelley
3 juli 2020 |
75 min
This week we respond to some listener feedback from Dr. Christopher Booth and use it to talk about how to be the best hematologist-oncologist. We also discuss the SADAL study on Selinexor for patients with relapsed refractory diffuse large B-cell lymphoma, as published in The Lancet Haematology.
Finally, we interview Drs. Eva Katsoulakis and Michael Kelley on their recent paper out in the Journal of Clinical Oncology: Precision Oncology, titled "Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program".
Selinexor: doi.org/10.1016/S2352-3026(20)30120-4
Annotation Services: doi.org/10.1200/PO.19.00118
Back us on Patreon! www.patreon.com/plenarysession
Check out our YouTube channel: https://www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew
2.58 RECOVERY & Twitter, Academic Debate, and Transitioning Your Career with Dr. Andrae Vandross
27 juni 2020 |
81 min
This week we briefly cover updates on the RECOVERY trial before segueing into an interview with Dr. Andrae Vandross on Twitter (specifically #medtwitter), academic discussions, and changing your career to find your calling.
RECOVERY: www.recoverytrial.net/
Malignant audiobook: www.audible.com/pd/B08864KFHW/?so…ACX0_195112_rh_us
Back us on Patreon! www.patreon.com/plenarysession
2.57 RECOVERY, Clinical Trials in the US, EFS, Writing, Dr. Raj Chetty, & Dr. Ian Tannock
19 juni 2020 |
135 min
This week's episode is jam-packed with topics! We talk about the RECOVERY trial, the U.S. clinical trial infrastructure, event-free survival (EFS) and cost of care in acute myeloid leukemia, how long it takes to write papers in academic medicine, threats to public health officials, and the application to medicine of Dr. Raj Chetty's work in economics. Finally, we interview this week's special guest, Dr. Ian Tannock, on docetaxel, prostrate cancer, clinical trial appraisal, and his career in medicine.
RECOVERY: https://www.recoverytrial.net/
EFS in AML: doi.org/10.1182/bloodadvances.2019001150
Malignant audiobook: https://www.audible.com/pd/B08864KFHW/?source_code=AUDFPWS0223189MWT-BK-ACX0-195112&ref=acx_bty_BK_ACX0_195112_rh_us
Back us on Patreon! www.patreon.com/plenarysession
2.56 HER2CLIMB & Misinformation and Disinformation with Dr. Cailin O'Connor
12 juni 2020 |
62 min
This week we tackle the topic of tucatinib in HER2-positive breast cancer with brain metastases. We also interview Dr. Cailin O'Connor of the University of California Irvine on her research on misinformation and disinformation. We discuss her recent article in the Boston Review, titled "Hydroxychloroquine and the Political Polarization of Science", as well as her extensive body of work.
HER2CLIMB: doi.org/10.1200/JCO.20.00775
Hydroxychloroquine: http://bostonreview.net/science-nature-politics/cailin-oconnor-james-owen-weatherall-hydroxychloroquine-and-political
The Dynamics of Retraction in Epistemic Networks: http://philsci-archive.pitt.edu/17088/
How Misinformation Spreads: https://www.scientificamerican.com/article/how-misinformation-spreads-and-why-we-trust-it/
Back us on Patreon! www.patreon.com/plenarysession
2.55 Hydroxychloroquine for COVID-19, ASCO, QOTW, Private Equity in Medicine with Dr. Jane Zhu
5 juni 2020 |
127 min
We start this week's episode by covering some recent research: After thoroughly critiquing the recent randomized trial of hydroxychloroquine for postexposure prophylaxis for COVID-19, we then discuss the five abstracts selected for plenary sessions at the recent virtual meeting of the American Society of Clinical Oncology. We transition from there to a Question from a Medical Student with Audrey Tran of Oregon Health & Science University on the recent decision to make the USMLE Step 1 exam pass/fail. Finally, we end with an interview with Dr. Jane Zhu, also of OHSU, on her current research and her new paper published in JAMA titled, "Private Equity Acquisitions of Physician Medical Groups Across Specialties, 2013-2016". Dr. Zhu first guest-starred on Plenary Session in episode 1.31.
Hydroxychloroquine: doi.org/10.1056/NEJMoa2016638
JAVELIN: https://meetinglibrary.asco.org/record/186872/abstract
ECOG-ACRIN: https://meetinglibrary.asco.org/record/186884/abstract
ENDURANCE: https://meetinglibrary.asco.org/record/186906/abstract
KEYNOTE-177: https://meetinglibrary.asco.org/record/186928/abstract
ADAURA: https://meetinglibrary.asco.org/record/191929/abstract
Private Equity Acquisitions: doi.org/10.1001/jama.2019.21844
Listen to the audiobook of Malignant with a free 30-day trial from Audible! https://www.audible.com/pd/B08864KFHW/?source_code=AUDFPWS0223189MWT-BK-ACX0-195112&ref=acx_bty_BK_ACX0_195112_rh_us
Back us on Patreon! www.patreon.com/plenarysession
2.54 Classical Hematology Chat on Thrombosis in COVID-19 & Drugs for COVID-19 with Dr. Walid Gellad
31 maj 2020 |
127 min
This week we talk all things COVID-19! We start with an in-depth Classical Hematology Chat with Dr. Sven Olson and Dr. Joseph Shatzel of Oregon Health & Science University on thrombosis and anticoagulation in COVID-19, touching on a number of recent studies. We then turn to a conversation with Dr. Walid Gellad of the University of Pittsburgh on new pharmaceutical treatments for COVID-19.
Tang et al. paper: doi.org/10.1111/jth.14768
Prospective autopsy study: doi.org/10.7326/M20-2566
COVID-19 compared to H1N1: doi.org/10.1056/NEJMoa2015432
Hypercoagulability of COVID-19: doi.org/10.1111/jth.14850
JACC letter: doi.org/10.1016/j.jacc.2020.05.001
JACC podcast: https://podcasts.apple.com/us/podcast/association-treatment-dose-anticoagulation-in-hospital/id932118437?i=1000474262300
Venous Thromboembolism in COVID-19: doi.org/10.1111/jth.14888
Back us on Patreon! www.patreon.com/plenarysession
2.53 Why Agreeing 65% with Someone is Important & COVID-19 Health Policy with Dr. Daniel Morgan
23 maj 2020 |
65 min
This week we discuss why being open-minded enough to agree partially with someone - instead of taking an all-or-nothing approach to a discourse - is important. We also sit down with epidemiologist Dr. Daniel Morgan of the University of Maryland School of Medicine to critique the public health policy concerning COVID-19 transmission.
Back us on Patreon! www.patreon.com/plenarysession
2.52 Malignant Audiobook, PROfound trial, & Literature and Medicine with Dr. Adam Cifu
16 maj 2020 |
104 min
This week we have an announcement -- the audiobook of "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer", written and narrated by our host Vinay Prasad, is available now on Amazon, iTunes, and Audible!
We also have an in-depth journal club for you on the findings of the PROfound trial as published in a new paper out in the New England Journal of Medicine titled "Olaparib for Metastatic Castration-Resistant Prostate Cancer".
Finally, we end the episode with an interview with Dr. Adam Cifu of the University of Chicago on literature, medicine, maintaining a feeling of normalcy and self during COVID-19, and more!
Listen to Malignant with a free 30-day trial of Audible: https://www.audible.com/pd/B08864KFHW/?source_code=AUDFPWS0223189MWT-BK-ACX0-195112&ref=acx_bty_BK_ACX0_195112_rh_us
PROfound: doi.org/10.1056/NEJMoa1911440
Crossover: doi.org/10.1093/annonc/mdy116
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2.51 BONUS! Clinical Trials Part 3
13 maj 2020 |
61 min
This BONUS lecture was a talk given to the Hematology/Oncology fellows at Oregon Health & Science University. It's part three of a three-part series on clinical trials.
Back us on Patreon! www.patreon.com/plenarysession
2.50 Neil Ferguson, Ending Lockdown, & Updates on COVID-19 Management with Dr. Benjamin Singer
7 maj 2020 |
67 min
This week's topic is all things COVID-19 -- we discuss the viral scandal of British epidemiologist Neil Ferguson's actions and how it reflects (or doesn't) on his work, we talk about the nuances of how to end lockdowns, and we bring back Dr. Benjamin Singer, a pulmonary and critical care physician at Northwestern University, to address updates in the ICU management of COVID-19.
Invisible Pandemic: doi.org/10.1016/S0140-6736(20)31035-7
Back us on Patreon! www.patreon.com/plenarysession
2.49 COVID-19 Contrarians, Remdesivir, & Book Club on "Malignant" with OHSU HemOnc Fellows
2 maj 2020 |
86 min
This week we begin with a monologue on the recent controversy surrounding Dr. John Ioannidis's published opinions on the COVID-19 pandemic. We end with a group discussion with Oregon Health & Science University's Hematology/Oncology fellows on our host's, Vinay Prasad's, new book "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer."
Expressing different views on COVID-19: https://www.statnews.com/2020/04/27/hear-scientists-different-views-covid-19-dont-attack-them/
Malignant: www.amazon.com/Malignant-Policy-Evidence-People-Cancer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.48 BONUS! Introduction to Malignant: How Bad Policy and Bad Evidence Harm People with Cancer
25 april 2020 |
21 min
This week we have a BONUS episode for you! As a teaser to the forthcoming audiobook of "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer" by Dr. Vinay Prasad (our host), Audrey Tran and Ian Straehley have set the introduction of the book to music they composed and arranged themselves.
You can buy the print version of Malignant from Amazon: https://www.amazon.com/Malignant-Policy-Evidence-People-Cancer-dp-1421437635/dp/1421437635/
Back us on Patreon! www.patreon.com/plenarysession
2.47 Remdesivir, Cloth Masks, & Incentives for COVID-19 Drug Development with Dr. Ameet Sarpatwari
16 april 2020 |
76 min
This week we start with an in-depth monologue on various new developments surrounding COVID-19, specifically the new study in NEJM on the compassionate use of remdesivir as well as the CDC's advice for the general public to wear cloth masks. We end with an interview with Dr. Ameet Sarpatwari of Harvard Medical School on how to create a more effective pharmaceutical system, the CREATES Act of 2019, developing fair and equitable drugs to treat COVID-19, and how to create a just system that balances the need for innovation with the need for access. Dr. Ameet Sarpatwari is the Assistant Director of PORTAL.
Compassionate Use of Remdesivir: doi.org/10.1056/NEJMoa2007016
U.S. Gene Therapy Trials: doi.org/10.1001/jama.2019.22214
NIH Fair Pricing Condition: doi.org/10.7326/M19-2576
Back us on Patreon! www.patreon.com/plenarysession
2.46 Psychology Unearthed by COVID-19 Precautions & Polygenic Risk Score with Dr. Venk Murthy
11 april 2020 |
93 min
This week we have a far-reaching monologue on COVID-19 and how people are reacting to the public health recommendations concerning COVID-19 (such as cancelling conferences and school, maintaining 6+ feet of distance, wearing cloth masks). We end with an insightful interview with Dr. Venk Murthy on polygenic risk score and, at the end, a bit about how the world of science is failing to combat hype.
Back us on Patreon! www.patreon.com/plenarysession
2.45 Viral Spread of SARS-CoV-2, Rationing Resources, "Evidence Fiasco", & Classical Hematology Chat
1 april 2020 |
87 min
This week we discuss several recent articles on the novel coronavirus (SARS-CoV-2) and COVID-19, specifically Dr. Siddhartha Mukherjee's article on the history and science of humanity's history with viruses, Dr. Ezekiel Emanuel's essay on how to fairly allocate dwindling medical resources during this global pandemic, and Dr. John Ioannidis's article on the "evidence fiasco" that has been our response to COVID-19. We end the episode with a Classical Hematology Chat with Drs. Sven Olson and Joseph Shatzel.
Dr. Mukherjee's article: https://www.newyorker.com/magazine/2020/04/06/how-does-the-coronavirus-behave-inside-a-patient
Allocation of Medical Resources: doi.org/10.1056/NEJMsb2005114
Dr. Ioannidis's article: https://www.statnews.com/2020/03/17/a-fiasco-in-the-making-as-the-coronavirus-pandemic-takes-hold-we-are-making-decisions-without-reliable-data/
Back us on Patreon! www.patreon.com/plenarysession
2.44 ICU Management of COVID-19 with Dr. Benjamin Singer
25 mars 2020 |
38 min
This week we discuss management of COVID-19 in the intensive care unit with Dr. Benjamin Singer, a pulmonary and critical care physician at Northwestern University. We discuss medications, PPE, ventilators, and more!
Back us on Patreon! www.patreon.com/plenarysession
2.43 BONUS! Novel Coronavirus and the COVID-19 Response in Oregon with Dr. John Townes
18 mars 2020 |
42 min
This bonus episode is an interview from March 16, 2020 with Dr. John Townes, the Interim Head for the Division of Infectious Disease and the Medical Director for Infection Prevention and Control here at Oregon Health & Science University. We talk about the novel coronavirus and how healthcare professionals are responding to the COVID-19 pandemic, with a focus on Oregon.
Back us on Patreon! www.patreon.com/plenarysession
2.42 Quality-of-Life Measurement in Oncology, KnowYourTumor, & Question of the Week
17 mars 2020 |
68 min
This week we discuss two recent papers -- one we praise, one we condemn -- and then we turn to a question of the week with medical student Audrey Tran on self-improvement and "refining conviction". The first paper is titled "Patient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials" and the second is titled "Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial".
Quality of Life Measurement: doi.org/10.1001/jamanetworkopen.2020.0363
KnowYourTumor: doi.org/10.1016/S1470-2045(20)30074-7
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.41 BONUS! Clinical Trials Part 2: Crossover and Control Arms
11 mars 2020 |
52 min
This BONUS lecture was a talk given to the Hematology/Oncology fellows here at Oregon Health & Science University. It's part two of a three-part series on clinical trials. This talk is on clinical trial design, specifically crossover and control arms.
Back us on Patreon! www.patreon.com/plenarysession
2.40 BEACON part 2, NALA, & Molecular Pathology and Next-Generation Sequencing with Dr. David Carr
5 mars 2020 |
69 min
This week we revisit BEACON! The authors of the BEACON study have responded to the Letter to the Editor our host Dr. Vinay Prasad submitted to the New England Journal of Medicine, and we share our thoughts on what they said. We then turn to the FDA's recent approval of neratinib in combination with capecitabine for HER2-positive breast cancer, based on the phase III NALA trial. Finally, we interview Dr. David Carr, a Molecular Pathology Fellow at UC San Diego, on his work in general and, specifically, next-generation sequencing.
BEACON Letters to the Editor: www.nejm.org/doi/full/10.1056/NEJMoa1908075#article_letters
NALA: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-neratinib-metastatic-her2-positive-breast-cancer
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.39 Effectiveness of Newer-Generation Antidepressants with Dr. Michael Hengartner
27 februari 2020 |
43 min
Our guest this week is Dr. Michael Hengartner of the Zurich University of Applied Sciences. We interview him on his work studying the long-term consequences and effectiveness of newer-generation antidepressants - specifically focusing on selective serotonin reuptake inhibitors (SSRIs).
Back us on Patreon! www.patreon.com/plenarysession
2.38 KEYNOTE-048, Academic Currency, & Trials in Low/Mid-Income Countries with Dr. Bishal Gyawali
19 februari 2020 |
52 min
We start this episode by diving deep into KEYNOTE-048, the randomized, open-label, phase 3 study of pembrolizumab alone or with chemotherapy v.s. cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (HNSCC). We transition from there to a continued discussion on careerism in academia and how the motivation behind publishing papers should always stem from the drive to disseminate information, not from the drive to advance your own career. We end the episode with an interview with Dr. Bishal Gyawali of Queen's University in Kingston, Canada on his recent paper out in Nature Cancer on global oncology. Specifically, Dr. Gyawali addresses the need for conducting cancer clinical trials in low- and middle-income countries.
KEYNOTE-048: doi.org/10.1016/S0140-6736(19)32591-7
Opportunities for Cancer Clinical Trials in LMIC: doi.org/10.1038/s43018-020-0030-x
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.37 Careerism, Presenting Abstracts, Twitter and the K-Index, & Classical Hematology Chat
14 februari 2020 |
70 min
We have a full slate for you this week! We discuss careerism in medicine, presenting abstracts at conferences, #MedTwitter, and Dr. Califf's opinions on the K-Index. We conclude the episode with our first-ever Classical Hematology Chat, featuring our host Dr. Vinay Prasad, Dr. Sven Olson, and Dr. Joseph Shatzel. The chat is on sickle cell disease.
"A Perspective on the K-Index": doi.org/10.1016/j.jaccas.2020.01.003
Back us on Patreon! www.patreon.com/plenarysession
2.36 Thought Leaders, NELSON, & Reliance on P Values in Cancer Trials with Dr. Sam Rubinstein
7 februari 2020 |
59 min
This week we discuss the concept of "thought leaders" and we examine the conclusions about volume CT screening for lung cancer from the NELSON trial. We end with an interview with Dr. Sam Rubinstein, a hematology/oncology fellow at Vanderbilt University Medical Center, on his new paper published in JAMA Network Open titled "Indication of Measures of Uncertainty for Statistical Significance in Abstracts of Published Oncology Trials: A Systematic Review and Meta-analysis".
NELSON: doi.org/10.1056/NEJMoa1911793
Measures of Uncertainty: doi.org/10.1001/jamanetworkopen.2019.17530
Back us on Patreon! www.patreon.com/plenarysession
2.35 BONUS! How to Keep Up with the New Information in Medicine
31 januari 2020 |
60 min
This BONUS episode is the recording of a lecture given to medical students titled "How to Keep Up with the New Information in Medicine." It's a primer on the steps healthcare professionals need to take in order to keep abreast of the latest medical findings.
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.34 Red Light, Pola for DLBCL, Hem/Onc Question of the Week, & TAILORx with Dr. Ali Khaki
24 januari 2020 |
92 min
We have a variety of topics for you this week! We tackle red light therapy, polatuzumab olatuzumab vedotin in relapsed or refractory diffuse large b-cell lymphoma; we have a hematology/oncology question of the week from Dr. Emerson Chen of OHSU; and we sit down with Dr. Ali Khaki of the Fred Hutchinson Cancer Research Center to discuss his recent paper critiquing TAILORx.
Pola for DLBCL: doi.org/10.1200/JCO.19.00172
Financial COI on Twitter: doi.org/10.1001/jamainternmed.2016.8467
Ignoring Valuable Data: doi.org/10.6004/jnccn.2019.7363
Back us on Patreon! www.patreon.com/plenarysession
2.33 Olaparib and POLO & the Classical Fallacies of Cancer Screening with Dr. H Gilbert Welch
15 januari 2020 |
74 min
This week we're treating you to a recording of the Grand Rounds lecture on overdiagnosis and cancer screening that Dr. H Gilbert Welch gave at Oregon Health & Science University on October 30, 2019. Before the lecture, we take a moment to reiterate with renewed vigor our distaste for the POLO trial (first discussed in episode 1.64).
POLO: doi.org/10.1056/NEJMoa1903387
Back us on Patreon! www.patreon.com/plenarysession
2.32 BONUS! Clinical Trials Part 1: Thinking Better About Cancer Medicine
10 januari 2020 |
53 min
This BONUS lecture was a talk given to the Hematology/Oncology fellows here at Oregon Health & Science University. It's part one of a three-part series on clinical trials, titled "Thinking Better About Cancer Medicine".
Back us on Patreon! www.patreon.com/plenarysession
2.31 Listener Questions, Responsibility of Reviewers, & Duration of Response with Dr. Bishal Gyawali
7 januari 2020 |
40 min
This week we answer a few questions: the first is from Patreon backer, Harry Hong, on Kaplan-Meier curves. The second is from a student at Mount Sinai Medical School who reached out with some ethical questions they had after the ASH annual meeting on the obligations and responsibilities of peer reviewers. Finally, we end the episode with an interview with Dr. Bishal Gyawali of Queens University in Kingston, Ontario, Canada on his new paper out today in the Journal of the National Comprehensive Cancer Network titled "Response Rates and Durations of Response for Biomarker-Based Cancer Drugs in Nonrandomized Versus Randomized Trials".
Durations of Response: doi.org/10.6004/jnccn.2019.7345
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.30 Questions from a Medical Student & Epidemiology with Dr. Ellie Murray
3 januari 2020 |
108 min
This week we return to our discussion of going after soft targets vs hard targets, but this time with a focus on how it applies to building a burgeoning career in medicine, in our segment Questions from a Medical Student with Audrey Tran. We end this week's episode with a far-reaching interview with Dr. Ellie Murray (most people know her as Epi Ellie on Twitter and as the co-host of the podcast Casual Inference) on all things epidemiology.
Check out Dr. Murray's excellent podcast here: https://casualinfer.libsyn.com/
Back us on Patreon! www.patreon.com/plenarysession
2.29 Time from Diagnosis to Treatment in AML and Real-World Data with Dr. Sherrie Aspinall
27 december 2019 |
69 min
This week we wonder incredulously how this abstract from ASH titled "Time from diagnosis to treatment does not affect outcome in intensively treated patients with newly diagnosed acute myeloid leukemia" was selected as one of the top abstracts from the conference. In the second half of the episode we interview Dr. Sherrie Aspinall of the Veterans Administration on how to use real-world data. Her new paper is titled "Use of targeted therapies for advanced renal cell carcinoma in the Veterans Health Administration".
Time from diagnosis to treatment in AML: https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2019-123717
Targeted therapies for advanced RCC: doi.org/10.1002/cam4.2531
Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.28 Trastuzumab in Later Lines of Therapy for HER2+ Breast Cancer, Kaplan-Meier Curves, & Patreon
20 december 2019 |
64 min
We're back in Plenary Session HQ! We have multiple topics for you this week. We cover the use of trastuzumab in later lines of therapy for HER2+ metastatic breast cancer, we take a listener question on Kaplan-Meier curves, and we talk a little about Patreon.
Malignant: www.amazon.com/Malignant-Policy-Evidence-People-Cancer/dp/1421437635
Back us on Patreon! www.patreon.com/plenarysession
2.27 BONUS! Use of Bone-Modifying Agents Among Medicare Beneficiaries with MM with Dr. Arjun Gupta
12 december 2019 |
26 min
This BONUS episode is an interview with Dr. Arjun Gupta, a second-year hem/onc fellow at Johns Hopkins University, on his new paper out TODAY in JAMA Oncology titled ''Use of Bone-modifying Agents among Medicare Beneficiaries with Multiple Myeloma''.
Use of bone-modifying agents: doi.org/10.1001/jamaoncol.2019.5426
Back us on Patreon! www.patreon.com/plenarysession
2.26 Questions of the Week: Hematology/Oncology, USMLE Step 2 CK, & a bonus Hematology/Oncology
9 december 2019 |
40 min
This is the last week of pre-recorded episodes -- we'll be back next week with a fresh, hard-hitting monologue. In the meantime, we have three questions of the week for you. Two are inspired by the hematology/oncology boards and are presented by Dr. Sven Olson. Between the two, we have one from Ian Straehely that's inspired by the USMLE Step 2 CK.
Back us on Patreon! www.patreon.com/plenarysession
2.25 Questions of the Week: Hematology/Oncology, the USMLE Step 2 CK, & One From a Med Student
2 december 2019 |
47 min
Our host is still out of town, but don't worry -- we have some questions of the week to tide you over. The first is inspired by the hematology/oncology boards, presented by Dr. Sven Olson; the second is inspired by the USMLE Step 2 CK, presented by Ian Straehley; and the third is from Audrey Tran, inspired by her experiences as a med student.
Back us on Patreon! www.patreon.com/plenarysession
2.24 Questions of the Week: the USMLE Step 2 CK, Hematology/Oncology, & One From a Med Student
26 november 2019 |
38 min
This week our host is still in Australia, but we have some questions of the week saved for you! The first is inspired by the USMLE Step 2 CK, presented by Ian Straehley; the second is inspired by the hematology/oncology boards, presented by Dr. Sven Olson; and the third is from Audrey Tran, inspired by her experiences as a med student.
Back us on Patreon! www.patreon.com/plenarysession
2.23 Question of the Week & Ethics and Inefficiencies of Clinical Trials with Dr. Jonathan Kimmelman
20 november 2019 |
58 min
First up this week is Question of the Week inspired by the Hematology/Oncology boards, with Dr. Sven Olson. No monologue on current trials this week because our host is still in Australia, so we conclude the episode with an interview with Dr. Jonathan Kimmelman of McGill University on his extensive work in research ethics, studying the most important issue in cancer medicine today: the risk-benefit of clinical trials and how best to spare patients from the burdens of creating a new drug.
Review of Sunitinib: doi.org/10.1093/jnci/djv292
Benefit, Burden, and Impact: doi.org/10.1177/1740774519873883
Back us on Patreon! www.patreon.com/plenarysession
2.22 Question of the Week & EMR, Talking to Patients, and Being a Doctor with Dr. Robert Hirschtick
15 november 2019 |
56 min
This week we have a question of the week from Ian Straehley, inspired by the USMLE Step 2 CK, as well as an interview with Dr. Robert Hirschtick of Northwestern University on what it means to be a doctor, how you should think as a physician, and his many popular pieces published in journals like JAMA.
"Copy-and-Paste": doi.org/10.1001/jama.295.20.2335
"Extremities": doi.org/10.1001/jama.300.10.1125
"The Quick Physical Exam": doi.org/10.1001/jama.2016.8182
Robiewon on YouTube: www.youtube.com/channel/UC2Ki7Zbo2VCGQAYinsJhU3w
"You Did Not Teach Me What You Thought You Did": doi.org/10.1001/jama.2019.15849
Back us on Patreon! www.patreon.com/plenarysession
2.21 Aiming for the Hard Targets & Harm From Screening and Overdiagnosis with Dr. H Gilbert Welch
8 november 2019 |
134 min
We begin this week's episode by addressing a listener's feedback to our discussion of smoldering multiple myeloma. We then expand on our critique of 'going after the soft targets' (criticizing studies that fall apart with little resistance) by elucidating how to identify and go after hard targets and why it's so important that you do. Finally, we launch into an interview with Dr. H Gilbert Welch that explores his tremendous body of work on the preventable harm that comes from too generous a hand with novel diagnostic advances.
Back us on Patreon! www.patreon.com/plenarysession
2.20 "Courageous Skeptics", Lenalidomide, QOTW, and a Political Conversation with Dr. Andy Saultz
1 november 2019 |
156 min
We begin this week's episode with a thoughtful discussion of the internet's "courageous skeptics". Then, after lamenting the way in which the recent study "Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma" was conducted, we end with an interview with Dr. Andy Saultz on his ongoing campaign for Oregon state representative. We break up the interview with a couple Hem/Onc boards questions of the week from Dr. Emerson Chen.
Lenalidomide in Smoldering Multiple Myeloma: doi.org/10.1200/JCO.19.01740
Back us on Patreon! www.patreon.com/plenarysession
2.19 Remembering Dr. Bernard Fisher & Self-Diagnosis with Dr. Mark Lewis
25 oktober 2019 |
133 min
This week we give a short monologue on the late Dr. Bernard Fisher's legacy in the field of oncology, and then dive into a far-ranging interview with Dr. Mark Lewis of Intermountain Healthcare on his career, his family, and diagnosing himself with MEN1 syndrome.
Dr. Fisher's obituary in the New York Times: https://www.nytimes.com/2019/10/19/science/dr-bernard-fisher-dead.html
Back us on Patreon! www.patreon.com/plenarysession
2.18 Questions of the Week, Talking About Toxicity, ASCO Guidelines Authors' COI with Dr. Eitan Amir
18 oktober 2019 |
77 min
This week we begin with a critique of the recent perspective article in the New England Journal of Medicine, titled "Talking about Toxicity — 'What We’ve Got Here Is a Failure to Communicate'". After that we interview Dr. Eitan Amir on his paper on undisclosed conflicts of interest among authors of ASCO guidelines. Interspersed between segments of the interview, we invite guest Dr. Sven Olson on to offer a correction to a recent Hem/Onc boards question of the week on Lynch Syndrome (original question posed in episode 2.11) and we invite Ian Straehley on for a question of the week inspired by the USMLE Step 2 CK.
Talking about toxicity: doi.org/10.1056/NEJMp1908310
COI among authors of ASCO guidelines: doi.org/10.1002/cncr.32408
Transparency in medicine: doi.org/10.1002/cncr.32407
Back us on Patreon! www.patreon.com/plenarysession
2.17 Questions of the Week, BEACON, & Use of Subacuate Rehab with Dr. Jonathan Yeh
8 oktober 2019 |
82 min
We start this week's episode with a quick breakdown of why the recent BEACON trial is "the worst trial" host VP has ever read. After that, we have two questions of the week: one from medical student Audrey Tran, and one inspired by the Hem/Onc boards from Dr. Sven Olson. We end with an interview with Dr. Jonathan Yeh of Johns Hopkins University School of Medicine on his recent paper: "Has There Been a Shift in Use of Subacute Rehabilitation Instead of Hospice Referral Since Immunotherapy Has Become Available?".
BEACON: doi.org/10.1056/NEJMoa1908075
Subacute Rehabilitation: doi.org/10.1200/JOP.19.00044
Back us on Patreon! www.patreon.com/plenarysession
2.16 FLAURA & What Truly Matters in the Career of an Academic Physician with Dr. Vinay Prasad
2 oktober 2019 |
98 min
This week we break down the limitations of the recent FLAURA trial and then we're back in the Plenary Session Mobile Command Unit! We have a special guest host, Dr. Christopher Booth of Queen's University in Kingston, Ontario, Canada. He and Dr. Bishal Gyawali, also of Queen's University, conduct a reverse interview with our usual host, Dr. Vinay Prasad of Oregon Health & Science University, on his career, the formation of Plenary Session, and what truly matters in the career of an academic physician.
FLAURA: doi.org/10.1056/NEJMoa1713137
Price of an Anticancer Drug: doi.org/10.1001/jamainternmed.2017.3601
Simply Measurable or Clinically Meaningful? doi.org/10.1200/jco.2011.38.7571
The Emperor Has No Clothes: doi.org/10.1200/JCO.2008.19.5594
Making Room in Oncology: www.medscape.com/viewarticle/917628
Back us on Patreon! www.patreon.com/plenarysession
2.15 Bonus! The Value of Progression-Free Survival as a Treatment Endpoint with Dr. Michael Raphael
26 september 2019 |
35 min
This BONUS episode is an interview with Dr. Michael Raphael of Sunnybrook Health Sciences Centre in Toronto, Ontario on his new paper out today in JAMA Oncology: "The value of progression-free survival as a treatment endpoint among patients with advanced cancer: a systematic review and qualitative assessment of the literature".
Value of PFS: https://jamanetwork.com/journals/jamaoncology/article-abstract/2751879
Back us on Patreon! www.patreon.com/plenarysession
2.14 Questions of the Week & Qualifications of a Fellowship Applicant with Dr. Jeremy Cetnar
24 september 2019 |
101 min
This week we sit down with Dr. Jeremy Cetnar, director of the Oregon Health & Science University Hematology & Oncology Fellowship Program. In this far-ranging interview, we discuss what he is looking for when reviewing applications to the fellowship program. We also have two questions of the week: one from Dr. Derrick Tao, inspired by the MKSAP; and one from Dr. Sven Olson on hematology and oncology.
Tweetorials: http://doi.org/10.1056/NEJMp1906790
Back us on Patreon! www.patreon.com/plenarysession
2.13 BONUS! RCTs Supporting Approvals of Cancer Drugs by EMA with Dr. Huseyin Naci
20 september 2019 |
40 min
On this week's BONUS episode, we sit down with Dr. Huseyin Naci, Assistant Professor of Health Policy at the London School of Economics, to discuss his new paper that came out Wednesday (producer's edit: not "yesterday" as said in the podcast - apologies for the delay!) in the British Medical Journal. The paper's titled "Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis."
RCTS Supporting Approvals: doi.org/10.1136/bmj.l5221
Back us on Patreon! patreon.com/plenarysession
2.12 Questions of the Week, Ethics of RCTs, & Transmission and Medical Overuse with Dr. Dan Morgan
17 september 2019 |
98 min
We begin this week's episode by revisiting last week's topic on the ethics of randomized controlled trials (RCTs) to address some of the controversy stirred up by our episode. We transition from there to an interview with Dr. Dan Morgan of the University of Maryland School of Medicine on hospital transmission and medical overuse. We have two questions of the week, as well -- one from Ian Straehley, inspired by the USMLE Step 2 CK; and one from Audrey Tran, inspired by the life of a medical student.
Back us on Patreon! www.patreon.com/plenarysession
2.11 Questions of the Week, When RCTs are Necessary, & AYA Oncology with Dr. Adam Duvall
12 september 2019 |
101 min
After a hiatus from our segment on reviewing recent trials, we return to discuss the need for randomized controlled trials (RCTs). In the wake of the 2019 World Conference on Lung Cancer, we focus on whether a phase III trial of selpercatinib (LOXO-292) in RET rearranged lung cancer is feasible, practical, and ethical. We also have two questions of the week in this episode -- one from Dr. Derrick Tao, inspired by the MKSAP; and one from Dr. Sven Olson on hematology and oncology -- as well as an interview with Dr. Adam Duvall of OHSU on his career in the field of adolescent and young adult (AYA) oncology.
Back us on Patreon! patreon.com/plenarysession
2.10 Questions of the Week: the USMLE Step 2 CK, the MKSAP, & Hematology/Oncology
5 september 2019 |
23 min
We have three questions for you this week: one from Ian Straehley, inspired by the USMLE Step 2 CK; one from Dr. Derrick Tao, inspired by the MKSAP; and one from Dr. Sven Olson on hematology and oncology.
Back us on Patreon! www.patreon.com/plenarysession
2.09 Questions of the Week & Informed Consent in Clinical Trials with Dr. Lynn Jansen
28 augusti 2019 |
80 min
We start this week with two Questions of the Week: the first is from Ian Straehley on the USMLE Step 2 CK, and the second is from Dr. Sven Olson on hematology/oncology. We end with an interview with Dr. Lynn Jansen of OHSU on the therapeutic misconception, optimism bias, and a deep discussion of the ethics of consenting patients for enrollment in early-phase clinical research trials.
Back us on Patreon! www.patreon.com/plenarysession
2.08 Questions of the Week: the MKSAP, the USMLE Step 2 CK, & From a Med Student
22 augusti 2019 |
37 min
We have three questions for you this week: one from Dr. Derrick Tao, inspired by the MKSAP; one from Ian Straehley, inspired by the USMLE Step 2 CK; and one from Audrey Tran, inspired by her journey through medical school.
Back us on Patreon! www.patreon.com/plenarysession
2.07 Translational Research & Physical Examination Pet Peeves with Dr. Adam Cifu
16 augusti 2019 |
77 min
We start this week's episode with a Question of the Week from medical student Audrey Tran on translational research and medical student training. Afterwards, we have an in-depth interview with Dr. Adam Cifu of the University of Chicago on his recent publication: "Physical Examination Pet Peeves".
Pet Peeves: doi.org/10.4300/JGME-D-18-01063.1
Back us on Patreon! www.patreon.com/plenarysession
2.06 Heart Failure, Choosing a Specialty, & the Bayesian Approach with Dr. Frank Harrell
6 augusti 2019 |
110 min
We're back with more questions of the week! Our first question, from Ian Straehley, is inspired by the USMLE Step 2 CK; our second question, from Audrey Tran, is on deciding on a medical specialty. We end the episode with an interview with Dr. Frank Harrell of Vanderbilt University on the Bayesian approach to statistical thinking.
Back us on Patreon! www.patreon.com/plenarysession
2.05 Reup! Cancer Screening 101 with Dr. Adam Obley
31 juli 2019 |
73 min
In this REUP episode, we replay a section of our interview with Dr. Adam Obley of OHSU: a primer on cancer screening. This audio was first aired on episode 2.03.
Not So Silver Lining: doi.org/10.1001/archinternmed.2011.73
Mammography Screening: Truth, Lies and Controversy: www.crcpress.com/Mammography-Screening-Truth-Lies-and-Controversy/Gotzsche/p/book/9781846195853
Back us on Patreon! www.patreon.com/plenarysession
2.04 Reup! Tumor-Treating Fields for Glioblastoma with Dr. Michael Hayes
30 juli 2019 |
36 min
In this REUP episode, we replay a section of our interview with Dr. Michael Hayes of Kaiser Permanente. This audio was first aired on episode 2.01. The interview is on the relationship between conflict of interest and editorial stance on tumor-treating fields for glioblastoma multiforme.
TTF: doi.org/10.1016/j.jcpo.2019.100189
Back us on Patreon! www.patreon.com/plenarysession
2.03 Dr. Charles Moertel and the Modern Oncologist & Cancer Screening 101 with Dr. Adam Obley
23 juli 2019 |
126 min
This week we launch a new segment on Plenary Session: Question of the Week! We invite Dr. Sven Olson on to ask a sample hematology/oncology boards question and we invite Audrey Tran on to ask a question from a medical student. Before that, we talk about the legacy of Dr. Charles Moertel and how modern oncologists, in contrast, will be remembered. We end the episode with an interview with Dr. Adam Obley of OHSU -- his fourth appearance on the podcast! -- on cancer screening.
Dr. Moertel's obituary: https://www.nytimes.com/1994/06/29/obituaries/charles-moertel-66-studied-treatment-and-cost-of-cancer.html
Faith Lost, a Doctor Turns Bitter: https://www.latimes.com/archives/la-xpm-1993-09-12-mn-34516-story.html
Not So Silver Lining: doi.org/10.1001/archinternmed.2011.73
Mammography Screening: Truth, Lies and Controversy: https://www.crcpress.com/Mammography-Screening-Truth-Lies-and-Controversy/Gotzsche/p/book/9781846195853
Back us on Patreon! www.patreon.com/plenarysession
2.02 BONUS! Improving Access to Prescription Drugs through Policy Change with Dr. Stacie Dusetzina
17 juli 2019 |
45 min
This BONUS episode is a recording of a lecture that Dr. Stacie Dusetzina of Vanderbilt University gave for grand rounds at OHSU on June 19, 2019. The lecture is on the cost of prescription drugs and out-of-pocket spending.
Back us on Patreon! www.patreon.com/plenarysession
2.01 Selinexor, ECHELON-2, Parachutes, Tumor-Treating Fields, & MedTwitter
12 juli 2019 |
158 min
Welcome to season 2! We're starting this season off with a little bit of everything: a critique of the FDA's accelerated approval of selinexor for penta-refractory multiple myeloma; an interview with Dr. John Reneau of Ohio State University on ECHELON-2 (brentuximab vedotin in t-cell lymphomas); an interview with Dr. Michael Hayes of Kaiser Permanente on parachutes in medicine plus the relationship between conflict of interest and editorial stance on tumor-treating fields for glioblastoma multiforme; and an interview with Dr. Stacie Dusetzina - a leading researcher in health care policy and the cost of cancer drugs, and an avid Twitter user - of Vanderbilt University on #MedTwitter.
ECHELON-2: doi.org/10.1016/S0140-6736(18)32984-2
Facing Our Mistakes: doi.org/10.1056/NEJM198401123100211
Parachutes: doi.org/10.9778/cmajo.20170088
TTF: doi.org/10.1016/j.jcpo.2019.100189
Impact of Disclosing Financial Ties: doi.org/10.1001/archinternmed.2010.39
Back us on Patreon! www.patreon.com/plenarysession
1.68 Voxeletor with Dr. Olson & Humanizing Cancer, Defining Cancer, and more with Dr. David Steensma
5 juli 2019 |
126 min
We begin this week's episode by breaking down the recent phase III trial on voxeletor in sickle cell disease with Dr. Sven Olson of OHSU. Next, we feature guest Dr. David Steensma of the Dana-Farber Cancer Institute in a far-reaching interview on being well-read, running a small lab, humanizing cancer, learning from our past use of erythropoiesis-stimulating agents, understanding the headache of contract research organizations, defining cancer, and more!
Voxeletor in Sickle Cell: doi.org/10.1056/NEJMoa1903212
Don't Mention It: doi.org/10.1200/JCO.2008.17.7238
The Raven: doi.org/10.1200/JCO.2017.76.3458
Erythropoietin Use in Cancer: doi.org/10.1200/JCO.2005.05.036
Contract Research Organizations: doi.org/10.1002/cncr.29994
Back us on Patreon! www.patreon.com/plenarysession
1.67 MONALEESA-7 and the Cost of Cancer Drugs with Dr. Stacie Dusetzina
27 juni 2019 |
140 min
This week we begin the episode by discussing MONALEESA-7 and why ribociclib has been shown to increase overall survival while palbociclib has not. We finish the episode with an in-depth interview with Dr. Stacie Dusetzina of Vanderbilt University on her work in pharmacoeconomics, specifically we discuss her work on the market value of cancer drugs.
MONALEESA-7: doi.org/10.1056/NEJMoa1903765
Free drug samples are a marketing tool: doi.org/10.2105/AJPH.2007.114249
Back us on Patreon! www.patreon.com/plenarysession
1.66 Employing Medical Writers & Frequentist vs Bayesian Methods with Dr. Allen Pannell
20 juni 2019 |
64 min
This week we open with a critical take on our current system of disseminating scientific research, specifically focusing on the prevalence of -- and dependence on -- medical writers. In the second half of the episode, we interview Dr. Allen Pannell of the Haslam College of Business at the University of Tennessee on using a Frequentist approach vs a Bayesian approach in the context of a single clinical trial.
Frequentist vs Bayesian: doi.org/10.1136/bmjopen-2018-024256
Dr. Pannell's breast cancer support group: https://www.breastconnect.org/
Dr. Pannell's research project: http://tinyurl.com/peerErPrHer2
Back us on Patreon! www.patreon.com/plenarysession
1.65 BONUS! Focusing and Building Your Presence on Twitter
12 juni 2019 |
40 min
In this BONUS episode we give advice on how to use Twitter effectively: how to focus your content, how to build your Twitter following, and how to conceptualize of the platform as an information network.
Back us on Patreon! www.patreon.com/plenarysession
1.64 Effectiveness of Cancer Screening with Dr. Joaquín Chapa and POLO with Dr. Emerson Chen
6 juni 2019 |
68 min
This week we discuss the recent paper "Interpreting the Effectiveness of Cancer Screening From National Population Statistics: Is It Sound Practice?" with its author, Dr. Joaquín Chapa of OHSU. We then revisit the POLO trial with Dr. Emerson Chen of OHSU, who disagrees with last episode's analysis.
Effectiveness of Screening: doi.org/10.1016/j.mayocp.2019.02.016
POLO: doi.org/10.1056/NEJMoa1903387
Back us on Patreon! www.patreon.com/plenarysession
1.63 POLO, TITAN, & from ASCO: FDA Approval, Surrogate Endpoints, and Patient Experience
4 juni 2019 |
83 min
This week we cover some of the highlights from this year's ASCO annual meeting. We discuss the POLO study "Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer" and the TITAN study "Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer", both recently published in NEJM. We end with a presentation titled "Expedited Program Use and Patient Experience in Trials", which was given in a shortened version at ASCO.
POLO: doi.org/10.1056/NEJMoa1903387
TITAN: doi.org/10.1056/NEJMoa1903307
Back us on Patreon! www.patreon.com/plenarysession
1.62 Rates of Cancer Screening, BILCAP Outcry, Waterfall Plots and Response Rate, & Dr. Jeff Sharman
23 maj 2019 |
92 min
We begin this episode by responding to listener feedback from episode 1.61's discussion of clinic appointment time and rates of cancer screening. We also tackle listeners' outcry over our take-down of BILCAP (spoiler alert: BILCAP is still a null trial) and how outcry like this highlights the need to train clinicians to think probabilistically. From there, we move on to discussing the recent paper by Myung Sun Kim in JAMA Network Open on waterfall plots and how they are a visual distortion of response rate. We end the episode with an interview with Dr. Jeff Sharman of Willamette Valley Cancer Institute in Eugene, Oregon on community oncology, enrolling patients in clinical trials, expertise of academia, and using real-world evidence.
Waterfall plots: doi.org/10.1001/jamanetworkopen.2019.3981
Back us on Patreon! www.patreon.com/plenarysession
1.61 Postpublication Metrics of RCTs, PCP Appointment Time, Bortezomib, & Dr. Christopher Booth
15 maj 2019 |
155 min
This week we cover three papers -- "Postpublication Metrics of Randomized Clinical Trials With and Without Null Findings" by Murray et al. in JAMA, "Association of Primary Care Clinic Appointment Time With Clinician Ordering and Patient Completion of Breast and Colorectal Cancer Screening" by Hsiang et al. in JAMA Network Open, and "Exceptional responders with invasive mucinous adenocarcinomas: a phase 2 trial of bortezomib in patients with KRAS G12D-mutant lung cancers" by Drilon et al. in Molecular Case Studies. We end with an interview with Dr. Christopher Booth of Queens University in Kingston, Ontario, conducted in the Plenary Session Mobile Command Unit.
Postpublication Metrics: doi.org/10.1001/jama.2019.2994
PCP Appointment Time: doi.org/10.1001/jamanetworkopen.2019.3403
Exceptional Responders: doi.org/10.1101/mcs.a003665
Back us on Patreon! www.patreon.com/plenarysession
1.60 I-PREDICT, Flawed Phase I Trials, & the Cost of Drugs with Dr. Daniel Hartung
9 maj 2019 |
80 min
We revisit I-PREDICT, discuss the "Imputability of Adverse Events to Anticancer Drugs" (a letter published recently in the New England Journal of Medicine), and interview Dr. Daniel Hartung of Oregon State University's College of Pharmacy on his vast knowledge of the cost of drugs, specifically addressing Acthar gel and multiple sclerosis drugs.
Imputability of Adverse Events: doi.org/10.1056/NEJMc1900053
Back us on Patreon! www.patreon.com/plenarysession
1.59 BONUS! Should Evidence Come with an Expiration Date? with Palmer Greene
8 maj 2019 |
19 min
In this BONUS episode, we interview Palmer Greene, a fourth-year medical student at the University of Chicago Pritzker School of Medicine, on his recent paper: "Should Evidence Come with an Expiration Date?", published in the Journal of General Internal Medicine.
Expiration Date?: doi.org/10.1007/s11606-019-05032-4
Back us on Patreon! www.patreon.com/plenarysession
1.58 Magic Mouthwash with Dr. Arjun Gupta & Precision Oncology with Dr. Talal Hilal
7 maj 2019 |
94 min
This week we discuss three paired papers on precision oncology published in Nature Medicine and then, later in the episode, go in-depth on the implications of these negative studies with Dr. Talal Hilal of the Mayo Clinic. We also discuss the use of magic mouthwash for oral mucositis with Plenary Session fan, Dr. Arjun Gupta of Johns Hopkins University.
WINTHER: doi.org/10.1038/s41591-019-0424-4
TARGET: doi.org/10.1038/s41591-019-0380-z
I-PREDICT: doi.org/10.1038/s41591-019-0407-5
Magic mouthwash: doi.org/10.1001/jamainternmed.2018.6223
Back us on Patreon! www.patreon.com/plenarysession
1.57 BONUS! Control Arm Quality in RCTs Leading to Anticancer Drug FDA Approval with Dr. Talal Hilal
2 maj 2019 |
34 min
In this BONUS episode, we interview Dr. Talal Hilal of the Mayo Clinic on his paper that was published today in JAMA Oncology, titled "Analysis of Control Arm Quality in Randomized Clinical Trials Leading to Anticancer Drug Approval by the US Food and Drug Administration".
Control Arm Quality: doi.org/10.1001/jamaoncol.2019.0167
Back us on Patreon! www.patreon.com/plenarysession
1.56 BONUS! Real World Data & the Search for Meaningful Cancer Care with Dr. Christopher Booth
1 maj 2019 |
49 min
This BONUS episode is the recording of a Grand Rounds lecture that Dr. Christopher Booth of Queen's University in Kingston, Canada gave this morning (May 1, 2019) at OHSU. The title is "Achieving the Achievable: Real World Data and the Search for Meaningful Cancer Care".
Back us on Patreon! www.patreon.com/plenarysession
1.55 Role of a Professional Society & More with Dr. Cliff Hudis of ASCO
29 april 2019 |
100 min
This week we sit down with Dr. Cliff Hudis, the CEO of the American Society of Clinical Oncology, to discuss the role of a professional society, the evolution of oncology, building a career, and more.
Back us on Patreon! www.patreon.com/plenarysession
1.54 Association of Patient Characteristics and Tumor Genomics with Clinical Outcomes & SABR-COMET
18 april 2019 |
34 min
In this week's episode, we break down two recently published papers. The first is "Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non–Small Cell Lung Cancer Using a Clinicogenomic Database" by Singal et al., published in JAMA. The second is "Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial" by Palma et al., published in The Lancet.
Characteristics and genomics: doi.org/10.1001/jama.2019.3241
SABR-COMET: doi.org/10.1016/S0140-6736(18)32487-5
Back us on Patreon! www.patreon.com/plenarysession
1.53 CALGB 50303, REMoDL-B, & REMS, Orphan Drug Act, and Role of the FDA with Dr. Ameet Sarpatwari
11 april 2019 |
106 min
We begin this episode with a discussion of two recent clinical trials in lymphoma: CALGB 50303 and REMoDL-B, respectively published in the Journal of Clinical Oncology and The Lancet Oncology. We include a primer on the history of lymphoma and the development of R-CHOP. We follow that with an in-depth interview with Dr. Ameet Sarpatwari of the Harvard Medical School on Risk Evaluation and Mitigation Strategies (REMS), the Orphan Drug Act, and, broadly, the purpose of the US FDA.
CALGB 50303: doi.org/10.1200/JCO.18.01994
REMoDL-B: doi.org/10.1016/S1470-2045(18)30935-5
Dr. Sarpatwari's online course: https://www.edx.org/course/the-fda-and-prescription-drugs-current-controversies-in-context
Back us on Patreon! www.patreon.com/plenarysession
1.52 BILCAP & DOACs for Thromboprophylaxis in Patients with Cancer with Dr. Sven Olson
4 april 2019 |
60 min
In this week's episode we critique the statistics of the recent trial "Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study" that was published in The Lancet Oncology. Then, with Dr. Sven Olson of OHSU, we break down the two papers published in NEJM on thromboprophylaxis with direct oral anticoagulants (DOACs) for patients with cancer: "Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer" and "Apixaban to Prevent Venous Thromboembolism in Patients with Cancer".
BILCAP: www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30915-X
Rivaroxaban: doi.org/10.1056/NEJMoa1814630
Apixaban: doi.org/10.1056/NEJMoa1814468
Back us on Patreon! www.patreon.com/plenarysession
1.51 BONUS! Study Time Reduction Using Surrogate End Points with Dr. Emerson Chen
2 april 2019 |
26 min
In this BONUS episode, we sit down for a quick interview with Dr. Emerson Chen of OHSU on his recent paper in JAMA Internal Medicine on how using surrogate end points as opposed to overall survival for FDA approval for oncology drugs only results in a reduced drug development time of approximately 11 months.
Study Time Reduction: doi.org/10.1001/jamainternmed.2018.8351
Back us on Patreon! www.patreon.com/plenarysession
1.50 Replacing RCTs, Physicians on Twitter, Open-Access, & Orthopedics with Dr. Kathryn Schabel
29 mars 2019 |
116 min
This week we tackle the recent paper published in the Journal of Clinical Oncology titled "Comparison of Population-Based Observational Studies With Randomized Trials in Oncology" as well as a couple papers lamenting physicians' use of Twitter and the open-access model for journal publishing. We end the episode with an in-depth interview with Dr. Kathryn Schabel of OHSU on orthopedic surgery and how she practices.
Observational Studies vs RCTs: doi.org/10.1200/JCO.18.01074
Back us on Patreon! www.patreon.com/plenarysession
1.49 Student Questions, Boeing 737 Max, Pancreatic Surveillance, Leukemia Drugs with Dr. Elihu Estey
22 mars 2019 |
115 min
We begin this episode by answering questions from a med student who is a Plenary Session fan. We transition from there to a discussion of the recent news stories on the FAA's handling of the Boeing 737 Max controversy and how this reflects on other USA regulatory agencies like the FDA. After a critique of the recent paper "Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance" published in the Journal of Clinical Oncology, we end with an interview with Dr. Elihu Estey of the University of Washington on his 40 years of experience as an oncologist, the "Renaissance" of drugs for leukemia, and advice for trainees on how to approach career goals.
Pancreatic Surveillance: doi.org/10.1200/JCO.18.01512
Back us on Patreon! www.patreon.com/plenarysession
1.48 Falsified Data in Meta-Analyses and the Expert Halo Effect with Dr. Stephanie Halvorson
13 mars 2019 |
60 min
This week we dive deep into an article in JAMA IM on falsified data in meta-analyses. We also discuss the recent JAMA viewpoint "Reducing the Expert Halo Effect on Pharmacy and Therapeutics Committees" with its author, Dr. Stephanie Halvorson of OHSU.
Falsified data: doi.org/10.1001/jamainternmed.2014.7774
Expert Halo Effect: doi.org/10.1001/jama.2018.20789
Back us on Patreon! www.patreon.com/plenarysession
1.47 BONUS! Medical Reversal: Class Lecture
11 mars 2019 |
57 min
This BONUS episode is a lecture on medical reversal that was pre-recorded for a class at Harvard Medical School. The recording was played for students in February of 2019 and followed by a Q&A. The slides referenced are available to Patreon supporters.
Back us on Patreon! www.patreon.com/plenarysession
1.46 BONUS! Personal Finances with Dr. Tom Beer
8 mars 2019 |
77 min
In this bonus episode, we bring back Dr. Tom Beer of OHSU from episode 1.33 to discuss how to manage your personal finances. The interview is aimed at young physicians, but there is something for all audiences as we cover a broad range of topics: paying off loans, optimizing retirement savings, buying a home, and investing.
Back us on Patreon! www.patreon.com/plenarysession
1.45 Real-World Data, Gottlieb, & Using the EHR for Meaningful Improvement with Dr. Deborah Cohen
6 mars 2019 |
59 min
This week's episode begins with praise for the recent article by Booth CM, Karim S, and Mackillop WJ on real-world data published in Nature Reviews Clinical Oncology. Next, we tackle the resignation of Scott Gottlieb as FDA commissioner and how we can measure the success of the FDA. Finally, we have an interview with Dr. Deborah Cohen of OHSU on effective communication between the clinician and the patient and how we can use data from the Electronic Health Record to make meaningful improvements in care.
Real-world data: doi.org/10.1038/s41571-019-0167-7
Back us on Patreon! www.patreon.com/plenarysession
1.44 BONUS! Screen Time and Children's Performance
1 mars 2019 |
47 min
This BONUS episode is the recording of a lecture given as part of the medical school class Appraising Medical Literature, taught at OHSU. This clip from the class critiques the recent JAMA Pediatrics paper "Association Between Screen Time and Children’s Performance on a Developmental Screening Test".
Screen Time: doi.org/10.1001/jamapediatrics.2018.5056
Back us on Patreon! www.patreon.com/plenarysession
1.43 Andexanet Alfa with Dr. Tom Deloughery & National Medicaid Policy with Dr. John McConnell
22 februari 2019 |
102 min
In this episode we discuss the controversy over the recent article in NEJM, "Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors", with Dr. Tom Deloughery of OHSU. We end with an interview with Dr. John McConnell, also of OHSU, on health economics and Medicaid.
Andexanet Alfa: doi.org/10.1056/NEJMoa1814051
Back us on Patreon! www.patreon.com/plenarysession
1.42 Caplacizumab for TTP with Dr. Sven Olson & Economics of Drug Pricing with Dr. Inma Hernández
13 februari 2019 |
77 min
In the first half of this episode, Dr. Sven Olson of OHSU joins us to help critique the recent NEJM paper, "Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura". In the second half, we interview Dr. Inmaculada Hernández of the University of Pittsburgh on her work on the economic principles behind runaway drug prices.
Caplacizumab: doi.org/10.1056/NEJMoa1806311
Back us on Patreon! www.patreon.com/plenarysession
1.41 Geneva Oath and Financial Relationships Among Guideline Authors with Dr. Joshua Niforatos
9 februari 2019 |
57 min
We feature two interviews this week: the first is a hallway conversation with [soon-to-be] Dr. Antonious Hazim of OHSU on the Declaration of Geneva and the second is a discussion with [soon-to-be] Dr. Joshua Niforatos on his recent paper in The American Journal of Emergency Medicine, titled "Financial relationships with industry among guideline authors for the management of acute ischemic stroke".
Financial relationships: doi.org/10.1016/j.ajem.2019.01.037
Back us on Patreon! www.patreon.com/plenarysession
1.40 The World of Hematology with Dr. Thomas Deloughery
6 februari 2019 |
65 min
This episode features an interview with hematologist Dr. Thomas Deloughery of OHSU. We cover a broad range of topics including 23andMe, wilderness medicine, academia, and Twitter. We'll be back next week with our regular introductory monologue!
Back us on Patreon! www.patreon.com/plenarysession
1.39 Looking Back On a Tenure in Medicine with Dr. Alex Denes
2 februari 2019 |
64 min
In this episode we interview Dr. Alex Denes of OHSU on his decades-long career in medicine: what practices have changed and what have stayed the same. No monologue this week - we'll be back next week with more insights!
Back us on Patreon! www.patreon.com/plenarysession
1.38 Lartruvo, New Directions for Cancer Trials, Gene Expression Profiling, & Dr. Miriam Knoll
26 januari 2019 |
98 min
In this episode we tackle Eli Lilly's drug Lartruvo (olaratumab) and the under-powered phase II trial that led to its FDA accelerated approval; a viewpoint in JAMA on new directions for cancer trials; and gene expression profiling for carcinoma of unknown primary. We end with an interview with Dr. Miriam Knoll of Hackensack Meridian Health on employment after residency or fellowship, residency training, and the medical specialty pipeline.
Back us on Patreon! www.patreon.com/plenarysession
1.37 BONUS! Medical Reversal for a General Audience
18 januari 2019 |
44 min
This BONUS episode is the recording of a talk given at the Salem City Club on January 11, 2019. It's the talk on medical reversal that has been featured in previous episodes, but this time the format and content have been updated for a broader, more general audience.
Back us on Patreon! www.patreon.com/plenarysession
1.36 Generic Price Competition & Military Surgical Advances with Dr. Martin Schreiber
15 januari 2019 |
76 min
This week we dive into the recent paper by Drs. Cole and Dusetzina titled "Generic Price Competition For Specialty Drugs: Too Little, Too Late?". We also have an interview with Dr. Martin Schreiber of OHSU on his experiences as a trauma surgeon, both stateside and on the battlefield.
Generic Price Competition: https://doi.org/10.1377/hlthaff.2017.1684
Back us on Patreon! www.patreon.com/plenarysession
1.35 BONUS! Conflict of Interest in Oncology
10 januari 2019 |
46 min
This BONUS episode is the recording of a lecture given to the Bioethics Study Group at OHSU on January 9, 2019 on conflict of interest, specifically in the field of oncology. Backers of our Patreon will be sent accompanying slides.
Back us on Patreon! www.patreon.com/plenarysession
1.34 Endpoints in ECOG-ACRIN 2511, Update to KEYNOTE-024, & Mentorship with Dr. Joseph Shatzel
10 januari 2019 |
71 min
In this episode, we discuss two recent papers published in the Journal of Clinical Oncology: ECOG-ACRIN 2511 and the update adding overall-survival and crossover results to KEYNOTE-024. We end with an interview with Dr. Joseph Shatzel of OHSU on mentorship.
ECOG-ACRIN 2511: http://doi.org/10.1200/JCO.18.00264
KEYNOTE-024 update: http://doi.org/10.1200/JCO.18.00149
Back us on Patreon! www.patreon.com/plenarysession
1.33 Guarantee-Time Bias & Trials, Philanthropy, and Cancer Research with Dr. Tom Beer
5 januari 2019 |
92 min
In this episode we discuss guarantee-time bias in the context of the recent JAMA Oncology paper titled "Profiling Preexisting Antibodies in Patients Treated With Anti–PD-1 Therapy for Advanced Non–Small Cell Lung Cancer". We also have an interview with Dr. Tom Beer, the Deputy Director of the OHSU Knight Cancer Institute, on clinical trials, leadership, philanthropy, and future directions in cancer research.
Profiling preexisting antibodies: doi.org/10.1001/jamaoncol.2018.5860
Back us on Patreon! www.patreon.com/plenarysession
1.32.1 Radiation Oncology with Dr. Brian Kavanagh
4 januari 2019 |
71 min
Episode 1.32 ran a little long, so this is episode 1.32.1 - we broke out the interview with Dr. Brian Kavanagh, the Chairman of Radiation Oncology at the University of Colorado, to make the interview more accessible.
Back us on Patreon! www.patreon.com/plenarysession
1.32 Rating Metrics, Conflict of Interest in the News, & Radiation Oncology with Dr. Brian Kavanagh
3 januari 2019 |
120 min
This week we discuss various academic indices including the h-index and the new Altmetric score, and we go over the recent NY Times article on conflict of interest. We end with an interview with Dr. Brian Kavanagh, the Chairman of Radiation Oncology at the University of Colorado.
NY Times: https://www.nytimes.com/2018/12/31/upshot/congratulations-on-the-promotion-but-did-science-get-a-demotion.html
Back us on Patreon! patreon.com/plenarysession
1.31 Ketogenic Diet, COMET-1 and COMET-2, the Health Insurance Marketplace with Dr. Jane Zhu
27 december 2018 |
95 min
We begin this episode with a discussion of Dr. Mukherjee's ongoing study combining a ketogenic diet with PI3 kinase inhibition. We continue with a take on a recent reanalysis of COMET-1 and COMET-2, two failed randomized controlled trials of cabozantinib versus prednisone or mitoxantrone-prednisone in metastatic castration-resistant prostate cancer. We end with an interview on instabilities in the health insurance marketplace with Dr. Jane Zhu of OHSU, an expert in the Affordable Care Act.
Keto diet + PI3 kinase: https://www.nytimes.com/2018/12/05/magazine/its-time-to-study-whether-eating-particular-diets-can-help-heal-us.html
COMET-1: http://doi.org/10.1200/jco.2015.65.5597
COMET-2: https://doi.org/10.1016/j.eururo.2018.11.033
Back us on Patreon! https://www.patreon.com/plenarysession
1.30 BONUS! Clinical Trial Endpoints, Drug Approval, Incentives in Oncology
19 december 2018 |
70 min
This BONUS episode is the recording of a lecture given to the National Breast Cancer Coalition on December 11, 2018. It's on clinical trial endpoints, FDA drug approval, and incentives in oncology. Backers of our Patreon will be sent accompanying slides.
Back us on Patreon! www.patreon.com/plenarysession
1.29 RCT of Parachutes and Frameworks for Internal Medicine with Dr. Andre Mansoor
18 december 2018 |
78 min
We begin this episode with a critique of the recent paper in the BMJ, "Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial" and we end it with an interview with Dr. Andre Mansoor, discussing his new book: "Frameworks for Internal Medicine."
Parachutes: https://www.bmj.com/content/363/bmj.k5094
Back us on Patreon! https://www.patreon.com/plenarysession
1.28 Questionable FDA Drug Approvals and Building a Career with Dr. Chadi Nabhan
13 december 2018 |
65 min
In this episode we critique two recent FDA drug approvals (venetoclax in combination with azacitidine or decitabine or low-dose cytarabine; glasdegib in combination with low-dose cytarabine -- both for acute myeloid leukemia)and we interview Dr. Chadi Nabhan, the Chief Medical Officer of Cardinal Health, on career transitions. The interview was taped on location at the 2018 annual conference of the American Society of Hematology in San Diego.
1.27 BONUS! Medical Reversal
6 december 2018 |
58 min
This BONUS episode is the recording of a lecture given to hospitalists at Kaiser Permanente on November 14, 2018. It's a slightly different version of the talk on medical reversals that we recorded for episode 1.16. Backers of our Patreon will be sent accompanying slides.
Back us on Patreon: https://www.patreon.com/plenarysession
1.26 Lesson From an ASH Abstract, Behind the Scenes of a Residency Program with Dr. Sima Desai
4 december 2018 |
74 min
Having just returned from the 2018 American Society of Hematology (ASH) Annual Meeting, we begin this episode by discussing the abstract of a study that stretches its conclusions. We dedicate most of the episode to an interview with Dr. Sima Desai, the program director for OHSU's Internal Medicine Residency Program. She gives some great insight on the program's inner workings.
ASH abstract: https://ash.confex.com/ash/2018/webprogram/Paper117448.html
We have also launched our Patreon page! Become a patron at www.patreon.com/plenarysession.
1.25 Welch's Legacy, Interpreting NGS, Uncertainty over Pregabalin, Beyond EBM with Dr. Sam Edwards
27 november 2018 |
81 min
In this episode we discuss: Dr. Gilbert Welch's Wikipedia page and how we should keep his decades of work in perspective, a Twitter conversation between experts on differing interpretations of results from next-generation sequencing, the new paper in JAMA titled "Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications", and finally, along with Dr. Sam Edwards of OHSU, we criticize the recent perspective piece in NEJM titled "Beyond Evidence-Based Medicine".
Welch's Wikipedia: https://en.wikipedia.org/wiki/H._Gilbert_Welch
Pregabalin: doi.org/10.1001/jamainternmed.2018.5705
Beyond EBM: doi.org/10.1056/NEJMp1806984
We have also launched our Patreon page! Become a patron at https://www.patreon.com/plenarysession.
1.24 Useless Medical Conferences and Dr. Adam Obley on Vascepa, Fish Oil, Vitamin D and Methotrexate
20 november 2018 |
50 min
In this episode we discuss John Ioannidis' article on the uselessness of medical conferences, published in JAMA: "Are Medical Conferences Useful? And for Whom?", followed by an interview with return-guest Dr. Adam Obley on a few recent clinical trials: Vascepa, fish oil, vitamin D, and methotrexate.
Medical conferences: doi.org/10.1001/jama.2012.360
1.23 BONUS! Developing Technology with Fewer Reversals: Maybe We Need More Translation Failure
15 november 2018 |
60 min
This BONUS episode is the recording of a lecture given as part of the Biomedical Engineering Seminar series at Oregon Health & Science University on November 9, 2018. The talk is on how to move technological devices to the clinic with fewer reversals.
1.22 Elo-Pom-Dex, Immunotherapy Combos, Inherent Bias, and the FDA with Dr. Erick Turner
13 november 2018 |
76 min
In this episode, we tackle the recent papers in the New England Journal of Medicine on "Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma" and "Immunotherapy Combinations in Multiple Myeloma", as well as a comment in The Lancet Oncology's editorial "9 Weeks That Matter for Patients With Gastric Cancer". We conclude with an interview with Dr. Erick Turner of OHSU on the FDA, regulatory capture, selective reporting, and transparency.
Elo-pom-dex: http://doi.org/10.1056/NEJMoa1805762
Immunotherapy combinations: http://doi.org/10.1056/NEJMp1803602
9 weeks that matter: http://doi.org/10.1016/S1470-2045(18)30752-6
Dr. Turner's seminal paper: https://doi.org/10.1056/NEJMsa065779
1.21 Nab-Paclitaxel in CCA, OS of PALOMA-3, Transparency, and Dr. Talal Hilal's Advice for Trainees
6 november 2018 |
73 min
In this episode we question the conclusions of the phase II trial "Nab-Paclitaxel and Gemcitabine as First-line Treatment of Advanced or Metastatic Cholangiocarcinoma", review the long-term overall survival results from PALOMA-3, discuss Dr. Gyawali et al.'s paper on the need for transparency in reporting harms from cancer drugs, and interview Dr. Talal Hilal from the Scottsdale Mayo Clinic on his advice for trainees.
Nab-paclitaxel and gemcitabine: doi.org/10.1001/jamaoncol.2018.3277
Palbociclib and fulvestrant: doi.org/10.1056/NEJMoa1810527
Reporting harms: doi.org/10.1136/bmj.k4383
1.20 Precision Oncology: Some Benefit, Mostly Hype and Mentorship with Dr. Andrae Vandross
30 oktober 2018 |
97 min
We begin this episode analyzing the unrepentant hype of precision oncology in a monologue that was originally one half of a debate titled: "Is Precision Oncology Generating Patient Benefit or Just Hype?" We conclude with an interview with Dr. Andrae Vandross on the mentor/mentee relationship.
1.19 BONUS! Introduction to Cancer Drug Policy
26 oktober 2018 |
50 min
This BONUS episode is the recording of a lecture given as part of a Cancer Intersession course for med students at Oregon Health & Science University on October 25, 2018. The talk is an introduction to cancer drug policy.
1.18 IMpassion130 and Hot-Spotting with Dr. Brian Chan
23 oktober 2018 |
63 min
In this episode we evaluate the IMpassion130 trial on the use of atezolizumab in triple-negative breast cancer. We also interview Dr. Brian Chan of OHSU on a randomized controlled trial he's running that tests whether Dr. Gawande's idea of "hot-spotting" -- tailoring interventions to medically complex patients -- does decrease hospitalizations.
IMpassion130: doi.org/10.1056/NEJMoa1809615
Hot-spotting: https://www.newyorker.com/magazine/2011/01/24/the-hot-spotters
1.17 BONUS! Interpretation of Cancer Clinical Trials
22 oktober 2018 |
78 min
This BONUS episode is the recording of a two-part talk addressed to oncology fellows given at Oregon Health & Science University on October 5 and October 12, 2018. The talk is on how to interpret cancer clinical trials.
1.16 BONUS! Crowdsourcing Data Analysis and Medical Reversal: Why 40% of What We Do is Wrong
17 oktober 2018 |
56 min
This BONUS episode is the recording of the Hospitalist Grand Rounds given at Oregon Health & Science University on October 11, 2018. The talk is on medical reversal. Before the talk we discuss the paper "Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results" by Silberzahn et al., published in Advances in Methods and Practices in Psychological Science.
Paper: doi.org/10.1177/2515245917747646
1.15 Minimally Effective Treatments, CheckMate 331, and Dr. Adam Obley on Low-Value Healthcare
16 oktober 2018 |
78 min
In this episode we review the recent paper in Nature Reviews Clinical Oncology by Booth, C.M. and Detsky, A.S. titled "Why patients receive treatments that are minimally effective?". We discuss the failure of CheckMate 331 to meet its primary endpoint despite having received accelerated FDA approval. Finally, we bring back Dr. Adam Obley (from episode 1.01) to talk about low-value healthcare, medical education, social media, and more!
1.14 BONUS! Immunotherapy in Desperation and the Pennington Lecture: Myths of Medicine and Marketing
12 oktober 2018 |
57 min
This BONUS episode is the recording of the 22nd annual Pennington Lecture given at Oregon Health & Science University on September 21, 2018. The lecture is on seven myths of medicine and marketing. Before the lecture we read and discuss the editorial "Desperation Oncology" by Tito Fojo, published in Seminars in Oncology.
1.13 KEYNOTE-189, Dr. Talal Hilal on MRD, and Medical Education with Dr. Adam Cifu
8 oktober 2018 |
97 min
Listen in for a breakdown of the good and the bad of KEYNOTE-189(trial published in NEJM), a discussion with Dr. Talal Hilal of the Mayo Clinic on the rise of minimal residual disease as a clinical endpoint, and an interview with Dr. Adam Cifu of the University of Chicago Pritzker School of Medicine on medical education, sham trials, and more.
1.12 BONUS! Evidence-Based Medicine Has Been Hijacked in Oncology
3 oktober 2018 |
37 min
This BONUS episode is the recording of a Grand Rounds talk given at Oregon Health & Science University on September 19, 2018. The talk was inspired by the article by JPA Ioannidis titled "Evidence-based medicine has been hijacked: a report to David Sackett", published May 2016 in the Journal of Clinical Epidemiology.
1.11 Peanut Gallery, Research Parasites, Appendectomies, HRQoL and PFS, Dr. Bishal Gyawali
2 oktober 2018 |
109 min
We discuss Dr. Califf's comment on the "social media peanut gallery of experts", Dr. Drazen's comment on "research parasites" and his retirement from NEJM, the recent paper in JAMA on long-term follow up for antibiotics as compared to appendectomies, and the paper in JAMA Internal Medicine on the relationship between health-related quality of life and progression-free survival. Finally, we interview Dr. Bishal Gyawali on a variety of topics, including cancer groundshot.
1.10 Criticism via Twitter, PACIFIC, PCI for CAD, and Dr. Rebecca Cooney of The Lancet
25 september 2018 |
73 min
Today we tackle some cardiologists' opposition to criticizing clinical trials on Twitter, the PACIFIC trial on durvalumab in stage III non–small-cell lung cancer, and the recent paper in Heart: "Percutaneous Coronary Intervention for Stable Coronary Artery Disease" by R.K. Al-Lamee, A.N. Nowbar, and D.P. Francis. We end with an interview on academic medical publishing with Dr. Rebecca Cooney, North American Executive Editor of The Lancet.
1.09 Response Rate in Phase I trials, JACOB, and MI, Stroke, and Metastasis as Hard Endpoints
20 september 2018 |
34 min
Special episode! We discuss the recent correspondence in NEJM on response rate in phase I clinical trials, the JACOB trial published in The Lancet Oncology on pertuzumab for HER2-positive gastric cancer, and we give an evaluation of MI, stroke, and metastasis as hard endpoints.
1.08 Hyperprolific authors, NCCN with Jeff Wagner, and Dr. Renee Dversdal on Ultrasounds
14 september 2018 |
63 min
In this episode we discuss hyperprolific authors and the recent comment in Nature by JPA Ioannidis, R Klavans, & KW Boyack; NCCN guidelines with fourth-year medical student Jeffrey Wagner; and point-of-care ultrasounds with Dr. Renee Dversdal of OHSU.
1.07 Adjuvant Sunitinib in RCC, future of EBM with Dr. John Mandrola
11 september 2018 |
63 min
In this episode we discuss the USA FDA's recent approval of sunitinib as the adjuvant treatment for patients with resected renal cell carcinoma who are at high risk of relapse. We also interview cardiologist Dr. John Mandrola on new directions forward for evidence-based medicine.
1.06 RELEVANCE, Jenny Gill, and Dr. Catherine Livingston of the Oregon Health Authority
7 september 2018 |
82 min
In this episode we break down the RELEVANCE trial published in the New England Journal of Medicine; discuss big data in observational studies with Jenny Gill, MS; and interview Dr. Catherine Livingston of OHSU, an expert in healthcare policy, on her work with the Oregon Health Authority and state Medicaid.
1.05 Cost and Efficacy of Cancer Drugs, ECHELON-1, Dr. Derrick Tao, and EBM with Dr. Martha Gerrity
5 september 2018 |
61 min
In this episode we cover the cost and efficacy of cancer drugs; review ECHELON-1; interview Dr. Derrick Tao of OHSU about his recent Lancet Oncology paper on poor control arms; and discuss evidence-based medicine with EBM expert and internist at OHSU, Dr. Martha Gerrity.
1.04: Nutritional Epi, Lenvatinib, Nivo and Ipi for Melanoma, and Dr. Avi O'Glasser
30 augusti 2018 |
57 min
This week's episode is on nutritional epidemiology by JPA Ioannidis; lenvatinib for hepatocellular carcinoma; nivolumab and ipilimumab for melanoma; and #medtwitter with Dr. Avi O Glasser from OHSU.
1.03: RWE, Right to Try, Talazoparib, Nivolumab, and Dr. Andrae Vandross
21 augusti 2018 |
66 min
We're moving to our new format. We begin with a monologue of the most noteworthy articles in this week's news. We'll be talking about real-world evidence, Right to Try, talazoparib, and the FDA approval for nivolumab in small-cell lung cancer. In the second half of the show, we'll interview Dr. Andrae Vandross, a community oncologist at UCLA Medical Center.
1.02: HemOnc Fellowship and Hype in Cancer Medicine with Dr. Jeremy Cetnar
16 augusti 2018 |
35 min
In episode 2, we discuss the fellowship program and then take a deep dive into hype surrounding cancer drugs. Our guest is Jeremy Cetnar, MD from Oregon Health & Science University.
1.01: Introduction and Dr. Adam Obley
14 augusti 2018 |
47 min
Join us for an introduction to who we are and what our podcast is about, then stick around for a hard-hitting discussion of evidence-based medicine, randomized controlled trials, sham controls, and broad next-generation sequencing in cancer. Our guest is Adam Obley, an Assistant Professor of Medicine at Oregon Health & Science University.
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En liten tjänst av I'm With Friends. Finns även på engelska.