#436: Charlene Van Buiten, PhD – Coeliac Disease & the Search for Novel Therapies

Coeliac disease is an autoimmune disorder stimulated by the ingestion of gluten, a protein found naturally in wheat, barley and rye. The condition affects approximately 1% of the Western world. However, currently the only approved treatment for coeliac disease is adherence to a gluten-free diet for life.

Therefore there is much research underway to develop alternative treatment options that may help these patients. One novel antigen-focused therapy that has been hypothesised is the use of plant bioactives.

Specifially, in vitro work by Dr. Charlene Van Buiten has looked as whether there is a mechanism by which polyphenols from green tea could be of benefit. Her work shows that these polyphenols can mitigate gliadin-mediated inflammation and intestinal permeability in vitro.

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