Morgan Levine & Jamie Justice | On Biomarker Standardization

“For me being able to quantify aging is one of the most important endeavours in the field. There is a lot of emphasis on intervening in aging, to either reverse or slow it, but I would argue that there’s no way to test if you did that if you can’t directly measure the thing that you’re trying to intervene in.”

In this session, Morgan Levine, Assistant Professor at Yale, gave a sneak peek into the new epigenetic clock they are developing that is able to probe into multiple organ systems, as well as a new approach how to calculate clocks that is much more reliable, enabling to generate insights from methylation clocks with much smaller samples required. 

The second talk was given by Jamie Justice, Assistant Professor at Wake Forest, that covered the current ways and strides the longevity field is making towards validating biomarkers of aging through clinical trials, showing on examples of a few senolytic trials they made. In the end, she also explained how exactly the TAME trial, which she is a coordinator of, should serve as a vehicle for the field to move further and have a flagship trial to validate new aging biomarkers against in the future.

Session summary: Biomarker Standardization | Morgan Levine, Yale, Jamie Justice, Wake Forest School of Medicine - Foresight Institute

The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.

Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. 

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