This Company's New Longevity Senolytic Drug & The Drug Development Process | 54 - David Scieszka

Subscribe to our channel: https://www.youtube.com/@optispan Check out Vertical Longevity Pharma: https://vertical-longevity-pharma.com/ Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. His last guest from the AGE meeting is David Scieszka, a longevity entrepreneur with a unique background that includes work as a PsyOps specialist for the US Army. David is currently working on Vertical Longevity Pharma, a senolytics company that he spun out from his postdoctoral work. He previously lead multiomics efforts at the biotech startup Norvoc Biosciences. David holds a PhD in biomedical sciences from the University of New Mexico School of Medicine, which he did concurrently with an MBA at the UNM School of Management. In this episode, Dave and Matt give us a peek into the drug development process (TL;DR: it isn't straightforward or cheap), from facing investor skepticism to considering endpoints, dosage, and potential side effects to collecting rigorous preclinical data that will satisfy requirements for U.S. Food and Drug Administration (FDA) approval. They also chat about further opportunities for the drug's use in companion animals, a demographic that would also enable a potentially faster path to FDA approval. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!