Stress, Immunity, and Illness: Insights from experimental common cold studies on holiday susceptibility

Can you believe it's almost the end of 2024?! Join me for a conversation with Dr. Aric Prather about stress, sleep, and social experiences at the holidays + what we know about links between those and our susceptibility to infections and severity of illness. We chatted about foundational knowledge drawn from studies where people are experimentally exposed to rhinovirus (aka the common cold) before moving to a conversation about health behaviors through the holidays. We hope this episode encourages you to indulge in social support and lean into the joy of this holiday season!

Dr. Aric Prather is a Professor and Pritzker Family Fund Endowed Chair in Health and Community in the Department of Psychiatry and Behaviroal Sciences at the University of California, San Francisco. He co-directs the UCSF Aging, Metabolism, and Emotions Center, is the Director of the UCSF Center for Health and Community, and Associate Director of the Stress Measurement Network. His research focuses primarily on links between sleep and health, particularly immune health, and his work is regularly featured in the New York TImes, NPR, and the Today Show.

Topics Discussed:

• Psychoneuroimmunology
• Susceptibility to Illness
• Severity of Illness
• Health Behaviors
• Sleep and Health
• Glucocorticoid Resistance
• Common Cold/Rhinovirus
• Social Support
• Resilience and Self-Care

Research Mentioned: 

• Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005;12(3):123-31.
• Prather, AA, Janicki-Deverts, D, Hall, MH, & Cohen, S. Behaviorally Assessed Sleep and Susceptibility to the Common Cold. Sleep. 2015;38(9):1353–1359.
• Cohen S, Janicki-Deverts D, Turner RB, Doyle WJ. Does hugging provide stress-buffering social support? A study of susceptibility to upper respiratory infection and illness. Psychol Sci. 2015 Feb;26(2):135-47.
• Access the Pittsburgh Common Cold Study data for yourself!
• Spiegel K, Rey AE, Cheylus A, Ayling K, Benedict C, Lange T, Prather AA, Taylor DJ, Irwin MR, Van Cauter E. A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Curr Biol. 2023 Mar 13;33(5):998-1005.e2. 
• Newman DB, Gordon AM, Prather AA, Berry Mendes W. Examining Daily Associations Among Sleep, Stress, and Blood Pressure Across Adulthood. Ann Behav Med. 2023 May 23;57(6):453-462. 

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which aims to better understand the relationship between stress and health by improving the measurement of stress in research studies. Learn more about available resources to support stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at [email protected] and we may feature your question in a future episode!