262: Spot on With T4SS Modulators

TWiM welcomes new host Petra, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion system that is essential for virulence of a variety of bacterial pathogens.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

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• A small protein regulates carbon utilization (PNAS)
• Inhibitors of type IV secretion systems (mBio)
• Letters read on TWiM 262

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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