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TWiV is a weekly netcast about viruses – the kind that make you sick. Brought to you by four university professors and a science writer.
The podcast This Week in Virology is created by Vincent Racaniello. The podcast and the artwork on this page are embedded on this page using the public podcast feed (RSS).
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease.
Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli
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Links for this episodeAngela – Good genes are nice, but joy is better Brianne – Beaker Hair Clip Kathy – Pareidolia explained by street artist David Zinn TEDx talk Also visit zinnart.com Alan – Screwworm is coming back in the Americas Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation
Listener PicksSarah – The Extremophile Campaign: In Your Home (ECIYH) citizen science
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Dear Reviewer 2 Rich – National Data Buoy Center Alan – BBC audio program on the World Morse Code Championships Vincent – These are the 20 most-studied bacteria — the majority have been ignored
Listener Picks
Peter – Local graffiti in Sydney Vivian – The Peoples’ Hospital by Dr. Ricardo Nuila
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, if “long COVID” like symptoms occurs after influenza and how long COVID may associate with neurological complicates that control verbal memory.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews some of their favorite virology stories from 2024.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Scientists put vampire bats on treadmills to learn about metabolism Kathy – Says Who?: A Kinder, Funner, Usage Guide for Everyone Who Cares About Words Rich – Mark Rober on PBS Newshour Brief But Spectacular (Wiki; Testing The World’s Smartest Crow) Vincent – How Glenn Gould Broke Classical Music
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients with kidney disease, provides information for Columbia University Irving Medical Center’s long COVID treatment center, SARS-CoV-2 infection affects skin conditions including shingles and if long antiviral treatment affects long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids.
Hosts: Vincent Racaniello, Rich Condit, and Jolene Ramsey
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Links for this episodeRich – Pareidolia (wiki) Jolene – Pathways to Science database Vincent – Wendy Carlos and Switched-On Bach
Listener PicksArjan – Gutsick Gibbon’s YouTube channel Alan – 2024 Nobel Prize Lectures in Chemistry
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center.
Subscribe (free): Apple Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews RFK Jr’s demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episodeAngela – Science’s 2024 breakthrough of the year, Lenacapavir “the long shot”. NEJM papers with Lenacapavir trials: one and two. Kathy – Bach Toccatta and Fugue on floor piano Rich – Never Cry Wolf Vincent – Common Raven and American Crow
Listener PickJaan – Meute (one, two, three)
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin deep dives into the whooping cough epidemic and bird flu in big cats, and in conjunction with your host Vincent Racaniello discusses the recent case of paralytic poliomyelitis in Israel, measles outbreaks and HHS campaign for vaccine safety campaign before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if the COVID mRNA vaccine is effective against symptomatic SARS-CoV-2 infection and hospitalization in children, where to find PEMGARDA, information for Columbia University Irving Medical Center’s long COVID treatment center, how long COVID effects one’s activities, personality and neuropsychiatric symptoms.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
At the School for Influenza in Brisbane, TWiV speaks with Kirsty, Erik and Rebecca about their careers and their research.
Host: Vincent Racaniello
Guests: Kirsty Short, Erik Karlsson, and Rebecca Cox
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult’s research, then returns to discussing the first case of severe disease following H5N1 infection in humans and the state of California’s “bird flu emergency”, the benefit of the measles vaccine, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how vaccination reduced hospitalization of children between 5-17 years, the ACIP recommendation for the immunocompromised, where to find PEMGARDA, information for Columbia Unversity Irving Medical Center’s long COVID treatment center, long COVID in cancer patients and the physical malaises of long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes?
Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey
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Links for this episodeAlan – Sondehub and radiosonde hunting Jolene – Book “10 to 25: The Science of Motivating Young People” By David Yeager Vincent – Dr. Vinay Prasad “Sabotaging RFK Jr’s Confirmation Will Increase Vaccine Hesitancy” & “Doctors Criticizing RFK Jr. Paved the Way for His Ascendancy”
Listener PicksSyl – Foldscope Jennifer – minutiae
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center’s long COVID treatment center.
Subscribe (free): Apple Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey
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Links for this episodeBrianne – Pale Blue Pod Kathy – PhysicsGirl recent Instagram post, ScienceAdvisor signup free daily sci news distillation, Semi-conducting hydrogels, Bot that can pick up things with a soft touch, “Pigeonbot II”, a drone called LisRaptor, zapping forever chemicals like PFAS with light and here Rich – Vendee Globe Jolene – Center for the Improvement of Mentored Research Experiences Vincent – These two ancient human relatives crossed paths 1.5 million years ago
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center’s long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member’s ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game, and an article about its origin Vincent – In the Quantum World, Even Points of View Are Uncertain
Listener PickRyan – A Dangerous Moment
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research.
Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel
Guests: Stephanie Gras and Jenna Guthmiller
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video Vincent – ‘We need to be ready for a new world’: scientists globally react to Trump election win
Listener PicksJack – Coronavirus vaccine update
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax’s combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeAngela – See a giant ‘ghost particle’ detector and more — October’s best science images Brianne – October 27 APoD: Bat nebula Dickson – Nikon Small World Contest 2024 winners Kathy – AAAS 150th anniversary video, celebrating scientists and Pew’s 2024 annual Trust in Science survey findings Rich – Cats Basically Are a Liquid After All, Study Confirms Alan – HHMI’s Beautiful Biology site Vincent – EcoHealth Alliance Fights Back
Listener PicksHunter – Don’t stop me now: Queen’s Brian May on saving badgers — and the scientific method Anne – Reasons to be cheerful
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation.
Hosts: Vincent Racaniello and Rich Condit
Guests: Mala Maini and John Tavis
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about “walking pneumonia”, the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if antiviral therapy prevents long COVID and viral sequalae in healthy young marines.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent with a crowbar Vincent – The expanding world of neuroscience
Listener PickJason – Solar eclipse on Mars and Polaris Program and their Harmony of Resilience Ryan – New York’s childhood vaccine coverage remains high
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden.
Host: Vincent RacanielloGuests: Niklas Björkström and Joakim Dillner
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – ASM Lesson Plans Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize
Listener PickLaura – Science of Public Communication (original article)
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episodeRich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.
Hosts: Vincent Racaniello and Jolene Ramsey
Guests: Krystyna Dabrowska and Rob Lavigne
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene RamseySubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episodeDickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.
Hosts: Kathy Spindler and Brianne BarkerGuest: Mary Estes
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Links for this episodeIntro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Viral adaptation to climate change Rich – “Understanding the biology of monkeypox virus to prevent future outbreaks” by B. Moss Vincent – We can now watch Grace Hopper’s famed 1982 lecture on YouTube
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – Googlegangers and AWWW clip Rich – RP FLIP (floating instrument platform) Alan – Big labs are bad for careers Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeDickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars Kathy – TBP for PCR internal control Rich – xmACIS2 compares the data in the ACIS database to that in GHCN-Daily Alan – Larry, the world’s most highly cited cat Vincent – The Viral Paleontologist Who Unearths Pathogens’ Deep Histories
Listener PickRyan – Mpox emergencies AP News one and two Rona – Up in smoke David – Ode to Joy (YouTube, TikTok)
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Kate Douglass: Olympian and Statistician (Swimming in Data) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha’Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women’s basketball team Rich – Texas State University Forensic Anthropology Research Facility Vincent – Sea lion ‘camera crews’ capture new footage of ocean floor
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.
Hosts: Vincent Racaniello
Guest: Judith Bruchfeld
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Links for this episodeIntro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – Dueling Banjos on banjo and kora Vincent – The world’s most expensive dinosaur and more
Listener PickMike – Science through a glass darkly Lisa – On A Mission“ Season Four
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli
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Links for this episodeAngela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth’s core has slowed so much it’s moving backward Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove Vincent – Seventh patient ‘cured’ of HIV: why scientists are excited
Listener PickCharles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeDickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episodeDickson – Stockholm Wood City Rich – “The Wide Wide Sea” by Hampton Sides Vincent – Tour de France stage 12
Listener PicksAmy – Earth Forced from the Protective Heliosphere: What Do We know?
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics.
Hosts: Vincent Racaniello and Alan Dove
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Links for this episodeAlan – The first few minutes of this video by Roger Barnes Vincent – Billy & Molly: An Otter Love Story
Listener PicksFernando – A City on Mars
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of “pasteurization” before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor’s subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episodeDickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking
Listener PicksBlog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli
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Links for this episodeAngela – Staring at the Sun — close-up images from space rewrite solar science Brianne – Water frost detected on Mars Volcanos Dickson – Best view yet of the Crab Nebula Vincent – Will Your Tattoo Give You Cancer: Probably Not…but Maybe?
Listener PicksJessica – Manchurian plague
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person’s time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis.
Host: Vincent Racaniello
Guests: Tapani Hovi and Caroline Tapparel
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Links for this episodeIntro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and FDA recommends switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey
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Links for this episodeBrianne – How to build a nuclear warning for 10,000 years’ time Rich – Doctor My Eyes | Jackson Browne Alan – WHO Health for All Film Festival winners Jolene – El enemigo de mi enemigo es mi amigo Vincent – A Population Dotmap of New York City and Race and Ethnicity in New York City
Listener PicksDavid – The greatest clock (and map) ever made Peter – The Mouse as a Microscope
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function.
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TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episodeAngela – Unconventional Sex Let Anglerfish Conquer the Deep Ocean Kathy – Doonesbury from 5-26-24. And Publish or Perish game Rich – Sky: Giant Sunspot Region 3664 and Resulting Auroras APOD video Vincent – Mysterious sea urchin plague is spreading through the world’s oceans
Listener PickAbdulaziz – Biomedical Scientist Answers Pseudoscience Questions
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID. For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117.
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TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Oldest virus in Neanderthal bones Brianne – Jeopardy! winner reveals entwined memory systems make a trivia champion Kathy – Bright future of intelligent fabrics primary article and Self-dyeing textiles (primary article) Rich – Farewell to HD Atlas; Boston Dynamics Retires HD Atlas Robot Alan – Why vaccinating cattle against H5N1 is hard Vincent – Singapore Airlines turbulence: why climate change is making flights rougher
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology.
Hosts: Dickson Despommier, Alan Dove and Brianne Barker
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Links for this episodeDickson - Nitrogen-fixing organelle in a marine algaBrianne – Mapping a lost branch of the Nile Alan – Interactive version of the updated USDA gardening zone map on NPR.
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088. Dr. Griffin also provides a list of apps for monitoring one’s health including brain health.
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Links for this episodeIntro music is by Ronald Jenkees
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Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Webby
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Links for this episodeBrianne – The Little Researcher (from Bioss) Alan – Global Polio Eradication Initiative’s OPV switch was “unqualified failure.” Vincent – Errant Science
Listener PicksMoragh – Paper Cuts Podcast
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin deep dives into infections of dairy cattle with high pathogenic influenza H5N1, how long virus has been circulating and if known anti-influenza antivirals can reduce secondary attack rates, before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster takes associates with long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, if administration of oral antiviral therapies can prevent the onset of post-acute sequelae following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, compares and contrasts the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance following SARS-CoV-2 infection and the epidemiology of the pandemic in a Kenyan refugee camp. For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episodeDickson – NASA’s Webb Finds Ethanol, Other Icy Ingredients for Worlds Alan – MyClimate.org calculators Vincent – Twenty-Five Lectures in Virology 2024
Listener PicksAlan – NPR story and interactive quiz on pandemic respiratory disease transmission Az – H5N1 Avian Flu in Mammals
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, the caveats for improper use of antibiotics to treat SARS-CoV-2 (a viral infection), continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of an anti-immunoglobulin E monoclonal antibody can be used for COVID-19 treatment, if inhibiting T-cell activation will reduce secretion and production of inflammatory cytokines including IL-6, if changes in the gut microbiome associate with post -acute COVID-19 syndrome, and the pulmonary and neurologic determinants of long COVID-19 such as the presence of neurofilament light chain in plasma. For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episodeDickson – Journey to the Andromeda Galaxy, Highest jump in human history Alan – What Does a Scientist Look Like? photo gallery by Nature, and public display in London Vincent – The Campus-Left Occupation That Broke Higher Education, I’m a Columbia Professor. The Protests on my Campus are not Justice
Listener PicksDavid – Blue Angels unbelievable footage
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course).
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin’ Vincent – A quote from Georgia O’Keefe: “I think it’s so foolish for people to want to be happy. Happy is so momentary – you’re happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher
Listener PicksJulia – Recent success in troubleshooting autoclave challenges Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, potential risk factors for severe disease following influenza infection before and SARS-CoV-2 circulation, before discussing if SARS-CoV-2 infection impacts sperm fertility, the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC,continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and long COVID. For more information about this body of work, For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeBrianne – Do Other Planets Have Solar Eclipses? Kathy – Radcliffe Wave and Mt. Etna smoke rings with video Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation Alan – Rogue attempt to clone giant sheep for captive hunting Vincent – The Scientists Rock. Literally.
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jason McLellan
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088.
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Links for this episodeIntro music is by Ronald Jenkees
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Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Paul Offit
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Links for this episodeDickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.
Host: Vincent Racaniello
Guests: Volker Lohmann
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.
Host: Vincent Racaniello
Guests: Sheree Yau and Victoria Queiroz
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli
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Links for this episodeDickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd
Listener PickAnne – Why Reed Jobs is betting on cancer innovations
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey
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Links for this episodeBrianne – The reappearance of Lake Manly Kathy – “Practical Playbook for Addressing Health Misinformation” Rich – Making It So: A Memoir by Patrick Stewart Jolene – Thinking Like a Phage by Merry Youle Vincent – The Science of Leap Year
Listener PicksBlog design – Anthony Fauci will reflect on his long government career in ‘On Call,’ to be published in June Peter – Republican warns of vaccines being slipped into vegetables: ‘A polio vaccine in there’
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Kathy Spindler
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Links for this episodeDickson – Sustainable energy in America 2024 factbook Kathy – Life Magnified USPS stamps Rich – “How plants communicate with each other when in danger” by Kasha Patel (Original Nature Communications article) Alan – A Sargasso Sea of Space card game. Vincent – Tell Me When It’s Over by Paul Offit
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episodeDickson – Visualizing Science: Illustration and Beyond Brianne – Vaccination from the Misinformation Virus and Invisible Corps Alan – Preventing needlephobia in kids Vincent – Two new Djs I discovered Rosana Nun and Sunset Cartel
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli
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Links for this episodeDickson – For Your Processing Pleasure: The Sharpest Pictures of Jupiter’s Volcanic Moon Io in a Generation Angela – Whale Scientists Rich – Benefit-risk assessment of vaccines; The Brighton collaboration standardized module for vaccine benefit-risk assessment; Vaccine adverse events: causal or coincidental?; Austin area Singing Valentines Vincent – International Day of Women and Girls in Science, 11 February
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episodeDickson – JWST details of 19 spiral galactic centers Rich – Great White Shark Attack And Breach Vincent – Black History Month and Lost Photographs of Black America
Listener PicksLouise – The Mystery Of The Village That Beat The Black Death Pierre – Three things airlines don’t want you to know Brandon – Professor Dave explains
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
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Links for this episodeDickson – Asian girl building a life building a fence to protect a bamboo house Rich – Gator Country: Deception, Danger, and Alligators in the Everglades by Rebecca Renner Alan – Strange Bedfellows, by Ina Park Vincent – Star and Sphere kit – try the main page too
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli
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Links for this episodeDickson – Concerto for Horn and Hardart, P. Schickele Angela – ChatGPT4 Brianne – How mRNA Vaccine Works, Why We Need Two Doses of mRNA Vaccine Rich – Evolutionary basis for the human diet: consequences for human health by P. Andrews, R.J. Johnson Vincent – Virology Lectures 2024
Listener PicksGeoff and Anonymous – Dickson Despommier wants our cities to be like forests
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the role of immune aberrations in long COVID and how vaccination may protect against developing long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you should know episodes: METI and SETI Kathy – Oppenheimer “Science, Mission, Legacy” documentaries from Los Alamos Lab One Two Three and Los Alamos National Laboratory Summer 2023 National Security Science: The Oppenheimer Issue Rich – The Wager: A Tale of Shipwreck, Mutiny and Murder by David Grann Alan – Less is Morse, an educational game Vincent – Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines
Listener PicksSonrisa – Microorganisms in Perspective Anonymous – Wow! Human Cells Vibrate With Resonant Frequency and It’s Technically Audible
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, dissociation of antiviral treatment from infection rebound, and long COVID, deaths due to administration of hydroxychloroquine, muscle abnormalities and extreme fatigue in individuals with long COVID-19 and how the economics of where you live make long COVID-19 more severe.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to McGill University in Montreal, Canada to join Angela for a discussion of the careers and the research of two faculty members, Corinne Maurice and Jesse Shapiro, and their PhD trainees Anshul Sinha and Sana Naderi.
Hosts: Vincent Racaniello and Angela Mingarelli
Guests: Corinne Maurice, Jesse Shapiro, Anshul Sinha and Sana Naderi
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects of SARS-CoV-2 infection and virus transmission in Italy between early 2020 and 2022, the guidelines to improve home ventilation, the safety and efficacy of the oral anti-viral molnupiravir and the use of convalescent plasma as a long term treatment as well as treatment specifically for the immune compromised, the ineffectiveness of antibiotics for treating COVID-19, the association of olfactory dysfunction and the administration of corticosteroids and the safety of the RSV vaccines licensed last year.
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Links for this episodeIntro music is by Ronald Jenkees
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For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek’s disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli
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Links for this episodeDickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – Earthquakes of the 20th Century Vincent – Animator Chris Georgenes especially Tricycle animation study
Listener PicksJason – Spot-on, quick booster explainer and “Inverse” vaccine Slashdot’s summary. the full article, primary research article Meika – Iceland earthquake site
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the outcomes of SARS-CoV-2, influenza and respiratory syncytial virus infection in pediatric communities under the age of 18 years, the treatment of infants with the human monoclonal anti-respiratory syncytial virus antibody to prevent hospitalizations, most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, how the SARS-CoV-2/COVID-19 pandemic affected school attendance and child healthcare, how exposure length influenced transmission of SARS-CoV-2, how the durability of the anti-SARS-CoV-2 antibody response to protect against virus re-infection, if administration of oral antiviral therapy affected viral rebound in either the unvaccinated or vaccinated populations, as well as a reminder of the ineffectiveness of antibiotics for treating COVID-19 and the effect of vaccination on post-COVID conditions in children between 5-17 years old.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler
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Links for this episodeDickson – Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music Kathy – Two APODS Winter solstice, 183 Days in the Sun and the Same color illusion Vincent – The American Academy of Microbiology discusses gain-of-function research of concern (GOFROC) and enhanced potential pandemic pathogens (ePPP)
Listener PicksGregory – Climate Change – A revised prediction – Steven Chu John – Detergent packs are kinda wishy-washy (Technology Connections)
Intro music is by Ronald Jenkees
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In his weekly clinical update Dr. Griffin discusses the annual economic burden of respiratory syncytial virus in adults in the US, recombinant or standard-dose influenza vaccine in adults under 65 years of age, maternal vaccine effectiveness against influenza-associated hospitalizations and emergency department visits in iInfants, influenza positive tests reported to CDC by US clinical laboratories, update on COVID-19, risk of severe maternal morbidity associated with SARS-CoV-2 infection during pregnancy, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation, long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study, and risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent visits the Max Planck Institute for Medical Research in Heidelberg, Germany to speak with Matthias Fischer about his career and his research on giant viruses, virophages, and their protist hosts.
Host: Vincent Racaniello
Guest: Matthias Fischer
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses monkeypox and chickenpox co-infection in southern Nigeria, vaccine effectiveness against influenza A, SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, four methods for monitoring SARS-CoV-2 and Influenza A virus activity in schools, efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19, a synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong, consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications, and risk of new-onset long COVID following reinfection with SARS-CoV-2.
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Links for this episodeIntro music is by Ronald Jenkees
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From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control.
Hosts: Vincent Racaniello and Heli Harvala
Guest: Eeva Broberg
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa.
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Links for this episodeIntro music is by Ronald Jenkees
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On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey
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Links for this episodeDickson – Biden skips climate summit (NY Times) Rich – Lilium electric VTOL jet Alan – The Far Land, by Brandon Presser Jolene – Bacteriophage T4 infection watercolor painting by David Goodsell Vincent – Using narratives and storytelling to communicate science with nonexpert audiences
Listener PicksDarach – It depends t-shirt
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing impact of COVID-19 on infant health, COVID-19 vaccine effectiveness against post- COVID -19 condition among 589722 individuals in Sweden, repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting, protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes among community-dwelling adults, the Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA vaccines, T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19, oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China, and how COVID-19 convalescent plasma therapy decreases inflammatory cytokines, therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial.
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TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Climate Action and How to find joy in climate action Brianne – A Virus that Generates Electricity Kathy – Intolerable Genius: Berkeley’s most controversial Nobel laureate Rich – Programmed DNA Elimination (PDE): Quanta; Current Biology Alan – KBDfans mechanical keyboard kits Vincent – The Covid Vaccine Windfall Turns for Pfizer and Moderna
Listener PicksMeika – Iceland Eruption or not?
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course.
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Links for this episodeIntro music is by Ronald Jenkees
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Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases.
Host: Vincent Racaniello
Guest: Kevin Messacar
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeDickson – 2023 expected to be hottest year on record after warmest October ever Kathy – You can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably) Alan – Landmark case to get sanitation declared a civil right Vincent – SciComm Studios
Listener PicksCharmaine – Petition fo National Science Appreciation Day Peter – Let’s eradicate polio this winter
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees
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On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli
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Links for this episodeDickson – Climate Science Angela – Spider Ballooning (Wikipedia) Kathy – Richard Harris Art Collection Rich – “The Murderbot Diaries” by Martha Wells Alan – Old Gods of Appalachia Vincent – Poetry Foundation
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.
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Links for this episodeIntro music is by Ronald Jenkees
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Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells.
Host: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Klaus Früh
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis.
Host: Vincent Racaniello
Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged
From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals.
Host: Vincent Racaniello
Guests: Ron Fouchier, Rafael Medina, and Louise Moncla
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli
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Links for this episodeDickson – The New City. How to Build Our Sustainable Urban Future Angela – 2023 Nobel Peace Prize Alan – The Ruin of All Witches, by Malcolm Gaskill Vincent – France kicks off bird flu vaccination despite trade backlash risk
Listener PickCharles – David Brooks and the $78 airport meal the internet is talking about John – Periodic Table of the Elements: Origins of the Elements AZ – Bronze statue of laboratory mouse knitting DNA in Russia
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged
TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Webb spots a building block of life on Jupiter’s moon Europa Rich – Are we really made of ‘star stuff?’ Learn about your body’s elements Alan – Avian flu has reached the Galàpagos Vincent – Why the US can’t have nice things
Listener PickAz – Free solo
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospitalization with COVID-19 in the UK.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – UN Climate Action and California sues oil companies for exacerbating climate change Brianne – COVID Drugs are a Miracle Cure for Cats Rich – American Prometheus by Kai Bird and Martin J. Sherwin Vincent – Free Carl Zimmer writings
Listener PickAnne – She wrote to a scientist about her fatigue. It inspired a breakthrough. Alan – This Tiny Parasitic Wasp Can Drill Through Plastic
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli
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Links for this episodeAngela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot (journal article) Brianne – The story of our universe may be starting to unravel Rich – Sunlight Changes Unequally All Year Long Alan – Arm swing asymmetry in overground walking Vincent – The Farm at the Javits Center
Listener PickAsal – Ig Nobel Prizes honor zombie spiders, rock-licking scientists, and a clever commode
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics.
Host: Vincent Racaniello
Guest: Marion Koopmans
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In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees
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Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis.
Host: Vincent Racaniello
Guests: Raul Andino and Kostya Chumakov
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech receive positive CHMP opinion for Omicron XBB.1.5-adapted COVID-19 vaccine in the European Union, clinical antiviral efficacy of Remdesivir in COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, clinical outcomes associated with overestimation of oxygen saturation by pulse oximetry in patients hospitalized with COVID-19, risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination.
Click arrow to play Download TWiV 1040 (19 MB .mp3, 27 min)
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TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey
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Links for this episodeDickson – “Cosmic Time Machine” Netflix documentary Kathy – Antarctican accents Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites Jolene – Perspective article on best practices for improving graduate admissions Vincent – Why Chandrayaan-3 landed near the moon’s south pole — and why everyone else wants to get there too
Listener PicksDouglas – On Climate Change and (Active) Climate Management Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and virological treatment failure, incidence of new-onset hypertension post–COVID-19: comparison with influenza, and post-acute sequelae of COVID-19 at 2 years.
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope Brianne – Question Mark in Space? Kathy – Quammen interview with Walter Isaacson Rich – Chrome Music Lab Vincent – Matters Microbial
Listener PicksTom – The (second) deadliest virus Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III) Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV infection during the 2022 seasonal peak, long-term risk of death and readmission after hospital admission with COVID-19 among older adults, safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic kidney disease and COVID-19, Fluvoxamine vs placebo for outpatients with symptomatic COVID-19, the effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in COVID-19 hospitalized patients 6 months after discharge, long COVID and significant activity limitation among adults, incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong, and diabetes following SARS-CoV-2 infection: Incidence, persistence, and implications of COVID-19 vaccination.
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TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – Project Hail Mary Rich – Bird Buddy Alan – Blood, Sweat, and Pixels and Press Reset Vincent – Are microplastics spreading infectious disease?
Listener PicksTom – Henrietta Lacks family settles lawsuit Kathleen – Why Insect Memories May Not Survive Metamorphosis
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation, core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.
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Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the “flu shot cheerleader,” but a cheerleader for flu shots.
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TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that protects mice against influenza A and B disease.
Hosts: Vincent Racaniello, Kathy Spindler, and Angela Mingarelli
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Links for this episodeAngela – The Deepest Breath Kathy – Pink snow Vincent – Scientist vs PowerPoint
Listener PicksFernando – The Enigma of Reason by Hugo Mercier and Dan Sperber and Language vs. Reality by Nick Enfield
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing progression to severe COVID-19, NIH launching of several phase 2 long-COVID treatment trials.
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TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis.
Hosts: Vincent Racaniello, Rich Condit, and Alan Dove
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Links for this episodeRich – The Final Covid-19 Grand Rounds: What Have We Learned? Alan – Teaching biology to Tibetan Buddhist monks Vincent – I got it from Agnes by Tom Lehrer and Why Oppenheimer has important lessons for scientists today
Listener PicksRyan – Paul Offit on PBS Newshour to explain RFK Jr.’s Congressional Hearing
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral resistance analyses from the Remdesivir phase 3 adaptive COVID-19 treatment trial-1, impact of Molnupiravir treatment on patient-reported COVID-19 symptoms in the phase 3 move-out trial, Molnupiravir for treatment of adults with mild or moderate COVID-19, delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula, relationship between azithromycin and cardiovascular outcomes in unvaccinated patients with COVID‐19 and preexisting cardiovascular disease, and the effects of COVID-19 on cognitive performance in a community-based cohort, clinical phenotypes and quality of life to define post-COVID-19 syndrome.
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David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID.
Host: Vincent Racaniello
Guest: David Tuller
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TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Phoenix hits 110 degrees for the 19th day in a row, setting national record Brianne – James Webb Telescope One Year Anniversary Photo Kathy – Drone awards photos Alan – WHO Film Festival winners Vincent – Thinking, Fast and Slow by Daniel Kahneman
Listener PicksDavid – The Mass Extinction Debates: A Science Communication Odyssey
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA is associated with asymptomatic SARS-CoV-2 infection, and the immunology of long COVID.
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Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne BarkerGuest: Dan Wilson
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Links for this episodeDickson – Jazz G.O.A.T.S – Louis Armstrong, Duke Ellington, Ella Fitzgerald Brianne – Defining the Anthropocene? Kathy – How to use your thermostat on A/C Rich – Star Trek: Strange New Worlds Vincent – Step Aside, Joe Biden
Listener PicksKim – Virus found in a boreal lake links ssDNA and dsDNA viruses and Structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exaggerated blood pressure elevation in response to orthostatic challenge a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization, long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism, and risk of cardiovascular disease after COVID‐19 diagnosis among adults with and without diabetes.
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Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine.
Host: Vincent RacanielloGuest: Kostya Chumakov
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Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft.
Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Katherine Wu
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Links for this episodeBrianne- Maropeng caves and Finding Homo naledi Kathy – Being Mary Tyler Moore Vincent – Google Isn’t Grad School
Listener PicksJohn – A new study found people are terrible at sitting alone with their thoughts. Alan – What if all viruses vanished?
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID.
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From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron.
Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Trevor Bedford
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In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterologous boost with an aerosolized Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults, awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure, melatonin effects on sleep quality of COVID-19 patients, female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders, and incident autoimmune diseases in association with SARS-CoV-2 infection.
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From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere.
Host: Vincent Racaniello
Guest: Eddie Holmes
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Links for this episodeIntro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization.
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Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk.
Host: Vincent Racaniello
Guests: Susan Weiss, Rick Bushman, Gigi Gronvall, and David Joanson
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In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome.
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Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases.
Host: Vincent Racaniello and Rich Condit
Guests: Todd Bell, Crystal Burke, John Dye, and Jay Hooper
Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred.
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In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. veterans, national trends in anticoagulation therapy for COVID-19 hospitalized adults in the United States, development of a definition of postacute sequelae of SARS-CoV-2 infection, neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms, long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms, and coronary microvascular health in symptomatic patients with prior COVID-19 infection.
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TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episodeAngela – May’s best science images – Nature Kathy – Historical reasons for resistance to recognizing airborne transmission Rich – Scan of Titanic reveals wreck as never seen before – BBC News Alan – Science Education in an Age of Misinformation Vincent – Equity, Diversity and Inclusion: When communication all changed
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients.
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Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities.
Host: Vincent Racaniello
Guests: Frank Aylward and Jed Fuhrman
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In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines.
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Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.
Host: Vincent Racaniello
Guests: Kanta Subbarao and Maria von Kerkhove
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In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19.
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TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episodeAngela – Night Science Kathy – Kermit, Jim Henson, Rainbow Connection Rich – Alexander Skarsgård Explains the Answer to Everything Vincent – Beyond the Noise with Dr. Paul Offit
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19.
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TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Immune #67: Can T cells Live Forever? Kathy – Hazel Scott, Trinidad Jazz star Alan – The Last Navigator, Steve Thomas Vincent – Nasal Spray Covid Vaccines: Hope or Hype?
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.
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Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detection and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories.
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Megan Crumpler, Ryan Relich, and Kirsten St. George
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In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”.
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In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19.
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The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli
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Links for this episodeIntro music is by Ronald Jenkees
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TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess. Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus. Signature songs: Girl From Ipanema; The Waters of March. Brianne – This is what it sounds like when plants cry Kathy – I know who you are by Barbara Rae-Venter Alan – Svalbard seed vault virtual tour Vincent – We’re Asking the Impossible of Vaccines by Katherine Wu
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Mohsan Saeed
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server • Spike and nsp6 determinants of Omicron attenuation (Nature) •China releases genomic data from Wuhan market (Science) •Timestamps by Jolene. Thanks!
Weekly PicksRich – For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions Alan – HMS Victory 3D animated tour Vincent – The Fight Over Penn Station and Madison Square Garden
Listener PicksDouglas – How’s Your City Doing? Ask the Honeybees.
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition.
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server • More evidence for SARS-CoV-2 spillover (Zenodo) •Polio cases linked to nOPV2 (Science; GPEI statement) •nOPV2 on TWiV 756 •Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) •Stability of nOPV2 in children (npj Vaccines) •2A changes compensate for 5′-UTR disruptions (Virology) •HBV shifts from naked to enveloped (Nat Comm) •Letters read on TWiV 995 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York
Listener PicksGary – Tony Fauci on PBS Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.
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Links for this episode
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol) •Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) •Letters read on TWiV 993 •Timestamps by Jolene. Thanks!
Weekly PicksBrianne – Xkcd: Lymphocytes Kathy – A brief history of Parafilm with video Alan – Mapping and exploring the USS Monitor wreck Vincent – Skype a Scientist
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment.
Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min)
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Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice.
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server •1918 influenza virus not lethal in nonhuman primates (J Virol) •mRNA vaccines control HPV-associated tumors (Sci Trans Med) •Letters read on TWiV 991 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington Rich – Protein synthesis: an epic on the cellular level Alan – Thomas Was Alone Vincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out
Listener PickCarol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses.
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server •Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) •Cross-protective mAbs against respiratory viruses (Nat Comm) •RSV prefusion F protein vaccine in older adults (NEJM) •Ad26.RSV.preF–RSV preF protein vaccine (NEJM) •Letters read on TWiV 989 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet). Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic Kathy – “That’s What They Say” podcast about pronunciation of “primer.” Rich – Slow motion art: 1 and 2 Vincent – Grammarly
Listener PickCharles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Arturo Casadevall returns to TWiV to explain the use of convalescent plasma to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Arturo Casadevall
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Links for this episodeRich - Flammarion engraving Alan - What Remains of Edith Finch Vincent - The CDC’s Long-Covid Deception
Listener PickBill - General Relativity For Babies
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episode•Register for ASV 2023 •MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Guinea (WHO) •Wild-type poliovirus type 3 from laboratory (Eurosurveillance) •Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS) •Letters read on TWiV 985 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara). Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park. Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers Vincent – DJ Miss Monique aka Olesia Arkusha
Listener PickMegan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Scott Hensley
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Links for this episode•Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Multivalent influenza mRNA vaccine (Science) •Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol) •Letters read on TWiV 983 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight. Brianne – HHMI Virus Explorer Vincent – Chris Luno
Listener PicksJohn – White-tail deer density and SARS-CoV-2 in white-tail deer Jessica – Classic cases revisited: Oscar the cat and predicting death
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode•Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •NSABB proposed oversight framework (pdf) •Stricter US guidelines for research (Nature) •Information on NSABB (NIH) •Consumption of viruses by protists (PNAS) •Letters read on TWiV 981 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues. Kathy – Measles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al. Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo) Alan – Mt. Washington Observatory webcam Vincent – Ask the Experts
Listener PicksRoberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2, effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated.
Hosts: Vincent Racaniello and Rich Condit
Guest: Paul Offit
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode•Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Nick Muzyczka passes •CDC planning wastewater testing for polio (CDC) •Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) •Vast world of viroid-like RNAs (Cell) •Timestamps by Jolene. Thanks!
Weekly PicksKathy – 3B new Milky Way objects, Green comet Rich – Virology under the Microscope—a Call for Rational Discourse Alan – Indie story-driven games series #3: Valiant Hearts: The Great War Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf
Listener PicksFlorencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli
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Links for this episode•Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Persistence of SARS-CoV-2 (Nature) •Endogenous retroviruses and senescence (Cell) •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s Tune Angela – World’s Longest Animal Brianne – Green Comet to Pass By Earth for first time in 50,000 years Alan – Indie games series: Golf Club Wasteland Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale
Listener PicksLisa – The River and the Wall
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Daniela Weiskopf
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Links for this episode•Research assistant position at FDA (pdf) •Register for ASV 2023 •Cross reactive T cells to SARS-CoV-2 (Science) •SARS-CoV-2 exposure history and T cell response (Cell Rep Med) •Spike T cells cross- recognize Omicron (Nature) •Ancestral SARS-CoV-2 T cells recognize Omicron (Nature) •NVX-CoV2373 induces T cell responses (J Clin Inves) •Letters read on TWiV 975 •Timestamps by Jolene. Thanks!
Weekly PicksBrianne – Video of viral attachment (based on this article) Alan – Starting a series of innovative indie video games. First up: The Longing. Vincent – The Amy Papers and Calendar for live events
Listener PicksJudy – Innate immune evasion strategies of SARS-CoV-2 Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Felicia Goodrum
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Links for this episode•Research assistant position at FDA (pdf) •The loss of binary (Curr Clin Micro Rep) •Virology in Peril (mBio) •Letters read on TWiV 973 •Timestamps by Jolene. Thanks!
Weekly PicksBrianne – “Leukocyte” immunology video parody Alan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subject Vincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car)
Listener PicksKaren – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of Disease Kevin – James Hoffmann and Bald and Bankrupt
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeOur favorite 2022 virology stories: •Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) •Dickson: Interviews with Paul Offit and Andy Slavitt •Rich: TWiV 948: Breathless with David Quammen •Kathy: TWiV 915: Mouse mouth to mouse mom •Brianne: Spillovers (TWiV 923 and 876) •Vincent: Giant viruses (TWiV 873, 906, 968) •Dickson: TWiV 960 – Getting Funky with Dan Wilson •Rich: TWiV 927: Merchlinsky vs monkeypox •Kathy: TWiV 958: Pass the RNA and have some venison pi •Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm •Twiverse •Letters read on TWiV 968 •Timestamps by Jolene. Thanks!
Weekly PicksDickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: Desafinado Brianne – A Full Circle Rainbow over Norway Kathy – Frozen soap bubbles Rich – It’s Turtles All the Way Down in the Fossil Record by Asher Elbein Vincent – Vincent’s Top Ten Music
Listener PicksCharles – Wayne Bergeron and Vince DiMartino MacArthur Park
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society.
Host: Vincent Racaniello
Guest: Carl Zimmer
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It’s Spring For You. Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic) Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
Listener PicksRona – WKCR, FM 89.9 Columbia‘s radio station Alan – XKCD Proxy Variable
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.
Host: Vincent Racaniello
Guest: Jeffery Taubenberger
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2.
Hosts: Vincent Racaniello and Alan Dove
Guest: Esper Kallas
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Links for this episodeAlan – A Voyage for Madmen Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease.
Hosts: Vincent Racaniello
Guest: Gary Whittaker
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic.
Hosts: Vincent Racaniello and Rich Condit
Guest: Paul Offit
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli
Guest: Chirara Mingarelli
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Links for this episodeAngela – OpenAI Playground and Nature Milestones: T cells Chiara – The Biggest Ideas in the Universe by Sean Carroll Kathy – Recycling PVC and here and here Rich – Brome Bird Care Squirrel Buster Plus (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze) Vincent – Journey to the Microcosmos
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variants, effect of wearing glasses on risk of infection with SARS-CoV-2 in the community, and data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Dan Wilson
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Links for this episodeDickson – Jazz Project: InstrumentalTrumpet: Clifford Brown/Miles Davis/Winton Marsalis. Clifford Brown: Signature album: Study In Brown, Signature song: Sandu; Miles Davis: Signature albums: Kind Of Blue; Sketches Of Spain; Porgy And Bess; Miles. Signature song: Time After Time. Wynton Marsalis: Signature album: Standard Time. Signature song: Do You Know What It Means To Miss New Orleans Brianne – Physicists Create a Wormhole Rich – Dec 1 APOD: Artemis 1 Flight Day 13 Vincent – An Ancient Language, Once on the Brink, Is a British Isle’s Talk of the Town
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for preventing COVID-19 among health care workers, alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, real-world evidence of novel treatments for COVID-19 on mortality: a nationwide comparative cohort study of hospitalized patients in the 1st, 2nd, 3rdand 4th wave in the Netherlands, and effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Jazz Project: Vocals Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett Brianne – ASV Curriculum Guidelines for Virology Courses Kathy – The Snow Cruiser Alan – Rescuing bats in Ukraine Vincent – Woodpeckers: The Hole Story PBS
Listener PicksFlorencia – World of Viruses Miguel – Foldscope
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Cedric Feschotte and John Anthony Frank
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Links for this episodeKathy – Wastewater Dashboard Rich – Artemis I Mission; Artemis I launch; Artemis I Map Vincent – Pasta Grammar
Listener PicksRich – Watch a virus in the moments before it attacks Justin – Respiratory syncytial virus
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michael Letko
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Links for this episodeBrianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula Kathy – APODs Jupiter, Lunar Eclipse Blood Moon, Ice Giant Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life) Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1
Listener PickDebby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jake Scott
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Links for this episodeKathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez Rich – Wilderness Safaris Photographic Competition 2022 Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week Vincent – Andrea Camillieri and his protagonist Inspector Montalbano
Listener PickFrank – Economics for the Future: Beyond the Superorganism Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.
Host: Vincent Racaniello
Guest: Richard Knight
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: David Quammen
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Links for this episodeDavid – Shepherd Brianne – Adventure Aquarium Kathy – DART results (Narrative, images) Rich – “Elementary” TV series Vincent – Stop passing the buck on intro science
Listener PickRich – Consensus
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Angela Mingarelli
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Links for this episodeDickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March Brianne – Why Chimps and Gorillas Form Rainforest Friendships Rich – Fly Water – FPV to New Depths Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions Angela – Nature’s Inspiring Women in Science Award Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Kathryn Hanley
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Links for this episodeKathy – Car Talk Puzzler Archive Rich – The Molecular Biologist Who Exposed the Soviet Union” by Sean B. Carroll Vincent – NYU Chemistry prof fired because his course was too difficult
Listener PickJack – The Everything Virus
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.
This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.
Laurie Garrett and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions and comments to [email protected]
Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Paul Offit
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Links for this episodeDickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.
Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.
Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System Kathy – Durable antimicrobial coating Rich – One Health Vincent – The works of Dashiell Hammett
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Eddie Holmes
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Tom Monath
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Links for this episodeDickson – Jazz – Small Group #3: Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five. Rich – Wilderness Safaris (wiki) Alan – Madhouse at the End of the Earth, by Julian Sancton Vincent – Raymond Chandler and his protagonist Philip Marlowe.
Listener PicksPhilip – Students bitten by bats inside college residence hall
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.
Hosts: Vincent Racaniello
Guest: Emma Thomson
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In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination, resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.
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Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.
Hosts: Vincent Racaniello
Guest: Cedric Feschotte
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In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
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TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Small groups: 3. Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django. Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth Vincent – Lab leaders wrestle with paucity of postdocs
Listener PicksGary – Stan Kenton Orchestra Miguel – Microsoft Premonition
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.
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TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson - Small groups: 1. Miles Davis Quintet. Signature album: Kind Of Blue. Signature song: So What. Brianne - World Excel Championships Kathy - Lyre bird background and video Alan – The Kissing Bug, by Daisy Hernandez Vincent -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö
Listener PicksJohn – Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer Carol – The Social Dilemma
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.
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Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
Guest: Andy Slavitt
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Links for this episodeDickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements Brianne – Cross-stitched Microbes Kathy – Time trials for bottle emptying Alan – Meow Parlor Vincent – VIRUS x1,000,000 (2022) by Drew Berry wehi.tv
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.
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Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Michael Merchlinsky
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Links for this episodeDickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958 Kathy – How the US Postal Service reads terrible handwriting Rich – JWST/chorizo gag Vincent – Bat Conservation Trust
Listener PicksBill – The End of Manual Transmission J – How the Krebs cycle powers life and death – with Nick Lane
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.
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TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Everyone Loses on Jeopardy Eventually Kathy – Climate spiral followed by Carl Sagan Rich – Most Popular Desktop Browsers 1993 – 2022 Alan – I Am Promise Vincent – Polio in New York
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection, if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.
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From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.
Hosts: Vincent Racaniello and Brianne Barker
Guests: Vincent Munster and Raina Plowright
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In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.
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From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Pamela Bjorkman and Andy Mehle
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In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.
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TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Redactle Kathy – Kirigami paper replacing plastic bubble wrap Rich – First Images from the James Webb Space Telescope (Gravitational lens; Einstein ring) Vincent – Spotted lanternfly
Listener PicksAnn – NASA Engineer Who Made the James Webb Space Telescope Work Sonrisa – Aloft – the pleasures and risks of flying
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.
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Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Paul Offit
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Links for this episodeDickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956) Kathy – Solargraphic analemmas Rich – Windy (desktop; app) Vincent – Why monkeypox is mostly hitting men who have sex with men
Listener PicksMark – Hand Wash Dance – NHK WORLD-JAPAN
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection.
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TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker.
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Links for this episodeDickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild Brianne – Origami antibody and virus Kathy – Turbines resistant to high winds Rich – Obi-Wan Kenobi (TV Series) Vincent – The next epidemic may be here. The US isn’t ready for it.
Listener PicksDavid: DALL E 2 Douglas – Jazz Online
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity.
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TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler.
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Links for this episodeDickson – Count Basie: April in Paris Kathy – Bird aerodynamics & inertia: lay article, video, Nature Rich – NASA Gateway (Thanks Ellis) Alan – Polio Eradication in Nigeria Vincent – The Tyranny of Merit by Michael J. Sandel
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants.
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TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – A Frog So Small, It Could Not Frog Kathy – A Grand Night In: The Story of Aardman Rich – Archive Vincent – Bandwagoning by Heran Darwin
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection.
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From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration.
Hosts: Vincent Racaniello and Michael Schmidt
Guests: Michele Banks and Jane Hartman
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TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Microbes Rule! at Liberty Science Center Rich – Artemis I update: Mission diagram, mission in photos, launch dates Vincent – Eco-sustainable 3D printed house – Tecla
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission.
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TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Lake Mead water level very low Brianne – Transplantation of a 3D printed ear made out of human cells Rich – nderstanding Vaccine Safety and the Roles of the FDA and the CDC and The Facts About Vaccine Safety Vincent – My new favorite backpack
Listener PickGreg – Against the Rules
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana.
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Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research.
Hosts: Vincent Racaniello
Guests: David Baltimore, John Coffin, and Harold Varmus
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults.
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In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.
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TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – How to grow food on the moon Brianne – APod May 16: Milky Way over French Alp Hoodoos Kathy – Covid Nationwide data visualization Rich – NIH All of Us Research Program Vincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?
Listener PickLisa – E.H. Danner Museum of Telephony
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.
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TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – The Milky Way’s Black Hole Comes to Light Kathy – River dolphins playing with anaconda Rich – Smallpox vaccination techniques; from knives and forks to needles and pins Alan – Vacuum Tubes: a Modern Aladdin’s Lamp Vincent – Books by Pamela Jane
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.
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TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Bacteria and Me Coloring Book Kathy – Smarter 3D printing Rich – Big Ben Restoring the Worlds Most Famous Clock 2021 Vincent – Scientific review articles as antivaccine disinformation
Listener PickSuellen – Your Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.
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TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.
Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld
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Links for this episodeDickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Scientific review articles as antivaccine disinformation
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.
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TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Apple AirTag Kathy – Dental art/sculpture/mobile/chandelier Alan – Vintage Radio and Communications Museum of Connecticut Vincent – For the Love of Enzymes by Arthur Kornberg
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera
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Links for this episodeDickson – Earth Day and Earth Day History Brianne – XKCD: Family Reunion Vincent – Tokaido: A Journey (DVD)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.
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Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi
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Links for this episodeBrianne – APod Stars and Globules in the Running Chicken Nebula Kathy – BioRender Poster Builder Rich – The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey Vincent – Baumgartner Restoration
Listener PickJ – Time, Einstein, and the coolest stuff in the Universe
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Webb Telescope’s coldest instrument reaches operating temperature Brianne – Video of a CTL killing a tumor cell Rich – Our Unfinished Pandemic (On the Media Podcast) Vincent – Lý Thị Ca
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.
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Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Plemper
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Links for this episodeBrianne – BioRender Poster Builder Alan – Hexbug cat toys Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine
Listener PicksSue – American Visionary Art Museum Frazer – Vaccine trial for killer elephant virus
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – Ketanji Brown Jackson confirmed to US Supreme Court Amy – Some threats just keep coming in waves Rich – Lady Bird Johnson Wildflower Center Vincent – Martijn Doolaard
Listener PicksAnn – Immunological memory to SARS-CoV-2 infection and vaccines Chris – Isoplexis
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.
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TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – The Search for a Model Octopus That Won’t Die After Laying Its Eggs Rich – Vaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White) and The Cutter Incident by Paul Offit Vincent – Simply Put: Vaccines Save Lives
Listener PicksRich – ‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag Neva – Elin Thomas, UK textile artist Viki – History of English Podcast
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.
Hosts: Vincent Racaniello and Amy Rosenfeld
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Links for this episodeAmy – Ben Franklin by Ken Burns Vincent – Thoughts on a second booster: Offit and Krause/Borio
Listener PicksPhilip – History of Clemson Blue Cheese Jack – Pipeline and A Special Report on Polio
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.
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Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episodeBrianne – Covid restrictions prevented dengue in hundreds of thousands of people in 2020 Vincent – Scotch Dual Lock 250 Reclosable Fastener
Listener PicksErin –JWT Preparation and Xploration Outer Space
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – World’s tallest wooden building Amy – Virus hunter in the Wuhan market Rich – WorldPop (example) Vincent – Karst Stone Paper
Listener PicksNeva – Can we vaccinate against EBV? and Paul Sutter reading a science paper
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.
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TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – NSURP 2022 Kathy – Virology Jobs Rich – 10 Steps from Seed to Cup (Graphic) Alan – Fathoms: The World in The Whale, by Rebecca Giggs Vincent – Worldwaterday.org
Listener PicksJeremy – Archaeology of Light
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – James Webb Space Telescope and Nature Conservancy Photo Contest Amy – A new strategy for staying one step ahead of the virus Rich – Searching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis Vincent – Blacktail Studio
Listener PicksRichard – Water Structure and Science
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.
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Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michael Worobey
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Links for this episodeBrianne – Kartchner Caverns (info from Wikipedia here) Kathy – Laminar flow and turbulent flow Rich – Wikipedia Vincent – The Human Lake by Carl Zimmer
Listener PicksBrad – NASASpaceflight
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.
Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld
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Links for this episodeDickson – Ship found at the bottom of the sea Amy – Vaccinating kids has never been easy Vincent – State data and CDC data on children and COVID-19
Listener PicksAndrew – Books by Randall Munroe
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.
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TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episodeBrianne – The Dinosaur Age May Have Ended in Springtime Alan – The Track of the Typhoon, and me reading it. Rich – 12 Monkeys Vincent – Anna Mason’s Art Channel
Listener PicksRichard – SARS-CoV-2 in animals: Situation report #9 Jason – Counting App and CountThings from Photos
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID.
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TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episodeAlan – Which Immune Cell Are You? and Michaeleen Doucleff’s article Rich – Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases by Paul A. Offit Vincent – Ebola on Canvas
Listener PicksLes – Ologies podcast
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals.
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TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021 Brianne – Which Immune Cell Are You? Rich – Nikola Tesla – 3D Anamorphosis Vincent – Paul’s Uncle Doesn’t Want to Get Vaccinated
Listener PicksBob – The 1969 Apollo Guidance Computer Anne – Decoding the Gurus with Dan Wilson Beth – FrenchGuyCooking
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info from Rich World Meteorological Org Rich – NIAID Global Research (Mali) Alan – New method for recycling electric car batteries Vincent – Q&A with A&V
Listener PicksAddie – Vaccine Podcast Jennie – Dr. Katelyn Jetelina, aka Your Local Epidemiologist
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld
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Links for this episodeDickson – European scientists set new record in production of nuclear fusion energy Amy – Alfredo’s Magic Wand Brianne – What Happened After the Chicken-Pox Vaccine? Rich – Year Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope Vincent – Economists Are Fueling the War Against Public Health
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.
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Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo
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Links for this episodeBrianne – When scientific conferences went online, diversity and inclusion soared Rich – Traffic flow measured on 30 different 4-way junctions Vincent – A Slot Machine, a Broken Test Tube by S.E. Luria
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Webb team begins aligning telescope Brianne – Our Solar System in True Color Is Really Something Else Rich – When the International Space Station retires, it will plunge into the ocean to die Vincent – Gateway Program and What One Really Expensive Means to US Train Travel
Listener PicksJack – Dr. Becky and Pasta or composer
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC.
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Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Nels Elde
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Links for this episodeBrianne – Groundhogs Emerge From the Scientific Shadows Kathy – Zig-zag Coast Guard search pattern Rich – Moon Phases 2022 (Lunar Reconnaissance Orbiter) Vincent – Kevin Cowtan’s Book of Fourier and Live Fourier Transformation Nels – Biology versus bias
Listener PicksDusty – Fighting bias in space
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeDickson - NASA Research Launches a New Generation of Indoor Farming Kathy -How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves
Listener PicksJay – Restoration of Ave Maria John – Pandemic humor
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C
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John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: John Mascola
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Links for this episodeBrianne – How Sesame Street is Handling the Pandemic Rich – Zamboni: How it works Alan – How lightning starts Vincent – Buon-A-Petitti
Listener PicksMeika –Wordle
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Jon Yewdell
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Links for this episode Weekly PicksJon – The Premonition by Michael Lewis Dickson – Nature photographer of the year 2021 Brianne – Should BioBank Volunteers Be Warned About Mutations? Rich – Czech singer Hanka Horká dies after intentionally getting infected by the coronavirusand Dena Dietrich Dies at 91 Vincent – Cuore di Cioccolato
Listener PicksBronwen – Schools must stay open John – Pandemic humor
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic.
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Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Alessandro Sette
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Links for this episodeBrianne – 75 years of research on human diseases in 1 minute Kathy – 10 second video of COVID-19 spread Rich – Diffraction spike Vincent – John’s Furniture Repair and Transcend Furniture Gallery
Listener PicksAlison – FDA drug shortages Ingrid – One woman’s mission to get vaccines to her rural Alabama town
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Favorite Science Photos of 2021 Brianne – Viruses, Vaccines, and COVID-19 videos from American Museum of Natural History Kathy – Klompas et al. “Current insights into respiratory virus transmission…” Rich – Leviathan Falls by James S.A. Corey Vincent – Ebola (1996) by David Molesky at The Incubator
Listener PicksRandall – Robert Malone & Peter McCullough: A litany of untruths Suellen – Omicron and the case of the hidden evolution – Understanding Evolution
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis.
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A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Every Pore on Your Face Is a Walled Garden Rich – “On Warts” by Lewis Thomas (Pdf) Vincent – Cells at Work Code Black 1
Listener PicksChris – Ria Lina on the Guilty Feminist podcast Duncan – Meet the green kleptos of the animal kingdom
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld
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Links for this episodeDickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies’ best shot against Omicron Brianne – Where is Webb? Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles Vincent – The Secret of Life by Howard Markel
Listener PicksJen – Antidote David – Rosie Revere, Engineer
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID.
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TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Don’t Look Up Kathy – spaceweather.com Rich – Video of a Green Flash (wiki) Alan – Fungally-modified violins Vincent – This Old Tony especially this segment
Listener PicksPaul – Deep Mind and AlphaFold Grant – SARS-CoV-2 reproduction cycle
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – EO Wilson (Ants and The Conversation) Brianne – The Best Fun Science Stories of 2021 Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story Alan – Owls of the Easern Ice, by Jonathan Slaght Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars
Listener PicksLarry – Immunity Jeff – Daily Hospital Surveillance Report
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin.
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment Alan – Sokobond puzzle game Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients.
Hosts: Daniel Griffin and Vincent RacanielloSubscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeIntro music is by Ronald Jenkee
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Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Paul Offit
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Links for this episodeBrianne - Virus snowflakes Dickson - The Year in Pictures 2021 Vincent - Our Life is Plasticized
Listener PicksGerry - Dan Barouch: COVID-19 Vaccine Development Louise - Pandora's Lab by Paul Offit
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Vaccine Scientists: Time’s 2021 Heroes of the Year Kathy – Snake dietary diversity Vincent – Alfred Wegener Institute on Instagram
Listener PicksNiclas – Once upon a time… Life
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – Cities at Night Amy – I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds Rich – International Dark Sky Association Vincent – SARS-CoV-2 variants
Listener PicksKeith – Ventusky
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – CDC U-M flu report (lay version, MMWR) Rich – Thagomizer Alan – Descent into Darkness by Edward Raymer Vincent – Funding: Blinding peer review
Listener PicksLynne – ACE2 in chewing gum
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi,
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Links for this episodeDickson – Plant Habitat-04 Brianne – The Coronavirus in a Tiny Drop Rich – Prophet in Purgatory by Jon Cohen Vincent – “ ’—All You Zombies—’ ” by Robert A. Heinlein (pdf)
Listener PicksMike – The Coronavirus in a Tiny Drop
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Immune Kathy – Elizabeth Lee Hazen and Rachel Fuller Brown, discoverers of nystatin oneand two Alan – Four Lost Cities by Analee Newitz Vincent – Deadly Choices by Paul Offit
Listener PicksRyan – Ronny Jackson (one and two)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
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Links for this episodeDickson – Pee Wee Herman aka Paul Rubens Brianne – APOD: Pleiades Vincent – A History of Poliomyelitis by JR Paul
Listener PicksRichard – Let’s talk about a familiar problem and a new tactic…. Sherri – Have the New Jab
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episodeKathy – Power of poop Alan – Under the Sky We Make, by Kimberly Nicholas Vincent – Enzymatic amplification of beta-globing sequences
Listener PicksPaula – Reasons to be Cheerful and The Night Witches by Bruce Myles Grant – George Carlin – Germs, Immune System
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – Rodney Dangerfield Amy – Calder at MoMA Rich – ‘Useless Specks of Dust’ Turn Out to Be Building Blocks of All Vertebrate Genomes Vincent – Structure of small viruses
Listener PicksCharles – It is raining you lied to me Dave – A Whole New Ball Game
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Click arrow to play Download TWiV 830 (67 MB .mp3, 112 min) Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeKathy – When do we get back to normal? Maybe now. Rich – The Covid-19 Pandemic Alan – Yaupon Brothers American tea Vincent – Cracking the genetic code (and Niremberg’s account)
Listener PicksJustin – Partisan vaccination Lisa – The Red Flag
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episodeBrianne – Coronavirus Neutralizing Antibodies and mRNA Vaccine Video Vincent – MHC restriction of cytotoxic T cell lysis (Nobel description)
Listener PicksLisa – Shall Furnish Medicine Bistra – Saving the World by Julia Alvarez
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Greg Zuckerman
Click arrow to play Download TWiV 824 (76 MB .mp3, 127 min) Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeDickson – Michael Palin Kathy – Science News Centennial Rich – Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age Vincent – Evidence for somatic rearrangement of immunoglobulin genes (and commentary)
Listener PicksMatt – Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic Brigitte – The Obscure Virus Club Justin – Eddie Holmes wins Prime Minister’s Prize for Science
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners.
Hosts: Daniel Griffin and Vincent Racaniello
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Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Best of Gilda Radner Brianne – This polio survivor is one of the last still relying on an iron lung Rich – WHO Announces Proposed Members of its Scientific Advisory Group for the Origins of Novel Pathogens (SAGO); (members) Vincent – Discovery of mRNA (paper one and two)
Listener PicksDoris – History of smallpox and smallpox vaccine Judith – How the immune system works
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schools, FDA authorizes Moderna boosters, results of TOGETHER trial for fluvoxamine, statins and 28 day mortality, and cognitive function in patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – The Animal Kingdom is Full of Genetic Screwballs Kathy – Science dresses, accessories from Svaha and Rosalind Franklin’s DNA diffraction dress Rich – The Saxon Stories Alan – Cincinnati’s “Old Cunny,” and audiobook version Vincent – Infectious QBeta viral DNA
Listener PicksJeff – The unvaccinated may not be who you think
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – Apod: The Dolphin Head Nebula Rich – The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories
Listener PicksJason – Home Assistant Alena – VirusCraft
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – Great Lakes Science Center, Cleveland Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows Alan – How to Make a Slave and Other Essays by Jerald Walker Vincent – A structure for deoxyribose nucleic acid
Listener PicksSteve – How the immune system actually works Lise – Lise Meitner: A Life in Physics
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – John Clease Brianne – Astronomy Picture of the Day: Swirl in the Southern Sky Kathy – Lise Meitner Statue is at the Humboldt University Rich – Google has the cleanest cloud. Now it’s helping other companies go green Vincent – Discovery of reverse transcriptase by Baltimore and Temin
Listener PicksSam – Air Travel Packing List Justin – PFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler
Guests: Moshe Arditi and Ivet Behar
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Links for this episodeDickson – Mel Brooks Kathy – Dickson’s art show at Fordham Rich – Saildrone captures footage from inside Hurricane Sam Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman
Listener PicksKathryn – Project Drawdown and the book Charles – Arrowsmith by Sinclair Lewis
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one.
Host: Vincent Racaniello
Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker
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Weekly Picks
Dickson - Sid Caesar - The German General Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life Rich - Seek by iNaturalist Alan - The hard part of making a game is ... everything Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free
Listener Picks
Bruce - Bat Superpowers Gary - We’re Already Barreling Toward the Next Pandemic
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – PhD Comics: Words Said By No Academic Ever Kathy – Bach Cello Suite #1 visualization Rich – Hypnagogia Vincent – Landsat 9 and Wiki
Listener PicksLori – Project Hail Mary by Andy Weir Kevin – Oak Savannahs
Intro music is by Ronald Jenke Send your virology questions and comments to [email protected]
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld
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Links for this episodeDickson – George Carlin: “Stuff” Amy – The best of me by David Sedaris Rich – You could have a secret twin (but not the way you think) Alan – Nuclear powered Gameboy Vincent – No, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer
Listener PicksMichael – The tangled history mRNA vaccines Fernando – 1493 by Charles Mann
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker
Guests: Chadi Saad-Roy and Caroline Wagner
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Links for this episodeDickson – Ernie Kovaks-Nairobi Trio Brianne – XKCD Summarizes this Episode Rich – Texas Coronavirus Antibody REsponse Survey (CARES) (Dashboard) Vincent – Elmer Pfefferkorn
Listener PicksCatherine – A Life on Our Planet Attila – How to improve your chances of nudging the vaccine hesitant away from hesitancy and toward vaccinationIntro music is by Ronald Jenke Send your virology questions and comments to [email protected]
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Sloan Foundation Theater Kathy – COVID vaccines work, even if you don’t have side effects lay article primary article Rich – Science Alone Can’t Heal a Sick Society by Jay S. Kaufman Vincent – Sandra Black SciArt
Listener PickRuth – Radio Lento podcast
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more.
Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier
Guest: Mya Breitbart
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Links for this episodeDickson – Official-Droodles-Home Alan – The 31st First Annual Ig Nobel Prize Ceremony video (and the text version) Vincent – Biden’s federal and business vaccine mandates
Listener PickAnonymous – The Ivermectin Episode – Behind the Bastards
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episodeIntro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Shane Crotty
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Links for this episodeBrianne – How the cat gets its stripes Kathy – Kurzgesagt on Giruses (giant viruses) and beautiful APOD Rich – The 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle Vincent – Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period
Listener PicksDebby – River Runner Lin – Your Vaccinated Immune System Is Ready for Breakthroughs
Intro music is by Ronald Je Send your virology questions and comments to [email protected]
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Victor Borge, Phonetic Punctuation Brianne – Cat TV Rich – Cochrane review: Ivermectin for preventing and treating COVID‐19 Alan – Cockpit video of flying into Oshkosh Vincent – Medical News Network Morning Medical Update
Listener PickJody – Human Body Theatre and Plagues: The Microscopic Battlefield
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – A microscopic video shows the coronavirus on the rampage Kathy – Sabin Oral Sundays in Cuyahoga County, 1962 Rich – The Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future Vincent – Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works
Listener PicksRonald – Immunity to COVID-19 could last longer than you’d think Agnes – Space Shuttle Prints
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeDickson – The Brilliant Abyss by Helen Scales Kathy – Solar System ball drop Rich – Dr. Fox effect Alan – Patty Wagstaff virtual airshow cockpit video Vincent – Office Hours
Listener PicksKaren – The Dog Will See You Now Alicia – Bio-Rad GTCA Song
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose.
Hosts: Daniel Griffin and Vincent Racaniello
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Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Paul Bieniasz and Theodora Hatiziiouannou
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Links for this episodeDickson – NIF and Photon Science: fusion reaction generates 1.3 MJ Brianne – The PCR Song Rich – 1) How Boston Dynamics’ Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour Theodora – Kevin Parry turning into random objects Vincent – Lex Fridman
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Climate Reports | United Nations Brianne – Astronomy Picture of the Day: A Perfect Spiral Rich – COVID-19 false dichotomies Alan – Fixing broken machines Vincent – MKBHD Studio Tour 2021
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Jeffrey Shaman
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Links for this episodeBrianne – The Social Lives of Giraffes Kathy – Saturn’s Iapetus, moon in 3-D Vincent – Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Virgin Hyperloop shows off the future Brianne – BioNumbers Rich – Advice will evolve as COVID situation changes Alan – Mars Perseverance-themed geocaching swag Vincent – Mattel’s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls
Listener PicksNancy – Vaccines at a Party Jeff – How to Survive a Plague, Part 2
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Nobel Prize Games Kathy – Snail sensors Rich – In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish Vincent – The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans.
Listener PickJake – NASA spinoff Peter – Bernard, the Extraordinary Moth
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Kiran Thakur
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Links for this episodeDickson – Simone Biles and Suni Lee Brianne – How Speed and Distance Dictate the Way Olympians Run Rich – CDC reversal on indoor masking prompts experts to ask, ‘Where’s the data?’ Vincent – Paul and the Mosquitos
Listener PickLin – Your Vaccinated Immune System is Ready For Breakthroughs
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – The Science of Swimming Kathy – Talking to the vaccine hesitant and covidactnow.org Rich – The Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki) Vincent – Russia discards Pirs docking port to clear way for new space station module (IG post)
Listener PickApril – Pemberton Aviation (Facebook, YouTube)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker
Guests: Joseph Hyzer and Moriah Szpara
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Links for this episodeDickson – Inside of Mars is not like Earth Brianne – AlphaFold Rich – Tesla motors Alan – Diving for antique beer Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.
Hosts: Daniel Griffin and Vincent Racaniello
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On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.
Hosts: Vincent Racaniello and Amy Rosenfeld
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episodeDickson – Current Map | U.S. Drought Monitor Brianne – A comic strip about immune responses Alan – Superliminal game Vincent – Birds are dying in NJ
Listener Picks2listening1 – Renewal Em – Cognitive Surplus
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – The Science of Chocolate Chip Cookies Alan – Keeping Black students in STEM Vincent – Antiviral Program for Pandemics
Listener PickMark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Ron Fouchier
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Links for this episodeBrianne – The Science News Cycle Kathy – mRNA Day Kariko & Weissman lectures and Q&A Vincent – Just Planes
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – You Know You’ve Worked Too Long in a Lab When… Alan – Massachusetts vaccine lottery Vincent – Coonhound paralysis
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.
Hosts: Daniel Griffin and Vincent Racaniello
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Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guests: Kristian Andersen and Robert Garry
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Links for this episodeKathy – STEVE over Copper Harbor, MI Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Laurie Garrett
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Links for this episodeBrianne – A Pivotal Mosquito Experiment Could Not Have Gone Better Kathy – Microbiology at the Movies Vincent – When a Good Scientist Is the Wrong Source
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir.
Hosts: Daniel Griffin and Vincent Racaniello
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A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.
Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld
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Links for this episodeAmy – A relic from the Jurassic era Alan – World of Wonders, by Aimee Nezhukumatathil Vincent – Tom Buck’s YouTube Channel
Listener PickVictor – Vaccines: A measured response
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeBrianne – Pandemics for Babies, Germ Theory for Babies, and Vaccines for Babies Kathy – Playing with Time Vincent – A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episodeDickson – Hotel Magdalena Brianne – Antibody Song by Raven the Science Maven Alan – How to play Magic: the Gathering Vincent – Steve Gibson’s rant on Security Now
Listener PickDavid – Coronavirus set to mu
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: David Fajgenbaum
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Links for this episodeBrianne – How Giraffes Beat High Blood Pressure Kathy – Orangutan optical illusion Vincent – Two quotes from Chasing My Cure by David Fajgenbaum
John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.
David: Never stop questioning and always follow the data.
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede Brianne – Send in the Bugs. The Michelangelos Need Cleaning. Rich – All landers and rovers on Mars animated in video with human scale Alan – Weird case cluster reported in MMWR 40 years ago; update on disease Vincent – Virus isolates, strains, variants – what are they?
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – Flat pasta that turns into shapes here and here Rich – Ad Fontes Media Bias Chart (wiki) Vincent – Martin Beck police mysteries
Listener PicksGreg – Stewart Lee on Loch Ness monster
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Robert Garry
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Links for this episodeDickson – 143 Optical Illusions and Visual Phenomena Brianne – The Arcane Research that Prepared Us for COVID-19 Rich – Hidden Brain podcast Alan – A scientific theory of gist communication Vincent – Divisive COVID ‘lab leak’ debate prompts dire warnings from researchers
Listener PicksJon – Moderna Science Day
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Hosts: Daniel Griffin and Vincent Racaniello
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Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans
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Links for this episodeKathy – My Octopus Teacher Rich – John Wyndam classic Sci Fi: The Chrysalids, The Day of the Triffids Vincent – SARS-CoV-2 Phylogeny and Spatiotemporal Spread (paper)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – Ants: workers of the world Amy – Let The Record Show by Sarah Schulman Rich – QAnon resembles the games I design Alan – Librivox Vincent – Stratechery
Listener PicksFernando – The 60-year old scientific screwup that helped COVID kill
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Darwin’s Arch Collapses Kathy – The woman who discovered the first coronavirus Rich – “Richard Feynman: The pleasure of finding things out” Vincent – CORONA Project
Listener PicksJH – Fungus kills cicadas Alan – Liftoff by Eric Berger
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – Five Deeps Amy – Premonition by Michael Lewis Alan – The Secret Life of Groceries by Benjamin Lorr Rich – The Way Ferrofluid Floats Above a Superconductor Is Unreal Vincent – Threading the NEIDL
Listener PicksIradis – SN15 Launch and Landing Blue Pilgrim – Howland Garden Tools
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.
Hosts: Daniel Griffin and Vincent Racaniello
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TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Lab.Hacks Lab Assistant App Rich – Weird viral DNA spills secrets to biologists; COVAX Kathy – Planet Earth Now Vincent – Variants at ViralZone
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Exotic mantis Brianne – Types of Scientific Paper Alan – Rusty Lake Games / Cube Escape Collection Rich – The Departed Could Soon Become Compost in Colorado; Recompose (wiki) Vincent – Public Health Image Library
Listener PickIvan – Apollo 11: As They Shot It
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episodeRich – The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project Kathy – ISS, Crew Dragon, and the sun Doubly warped world of binary black holes Vincent – Mr. Labman
Listener PicksJoy – Abandoned America: Matthew Christopher’s Autopsy of the American Dream
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeDickson – Olympus Image of the Year Award Alan – We need to improve the welfare of life science trainees Rich – Sheldrick Wildlife Trust; The Reteti Elephant Sanctuary Kathy – Aria Code Nessun dorma podcast Vincent – Covariants
Listener PicksJustin – How Pfizer Makes Its Covid-19 Vaccine
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne – Show Your Immune System Some Love Alan – Cyborg sea turtle Vincent – Thomas Brock dies
Listener PicksApril – The High Line Michel – Why you can’t compare Covid-19 vaccines
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – NASA ingenuity helicopter ride Brianne – Vaccine Efficacy Animation Kathy – Airglow over the Azores Vincent – Gisaid
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
Guest: Nadine Lamberski
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Links for this episodeBrianne – The Dream Vaccine Alan – Taking vaccines to Smith Island Kathy – Daily Overviews Subscribe Tulips Vincent – Nextstrain
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episodeDickson – A tiny particle’s wobble could upend the laws of physics Rich – COVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy Amy – Vaccine Anthems Vincent – DarkNet Diaries Ep. 86
Listener PicksSteve – Cover Your Freakin’ Face
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeBrianne – COVID-19: a disaster five years in the making Alan – The Tyranny of Merit Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway Kathy – The Transcontinental Burrito Tunnel Vincent – Trudy Rey’s YouTube Channel
Listener PicksJeff – Rebecca Lee Smith on Left Right and Center Ryan – Perfect Strangers (clip)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.
Hosts: Daniel Griffin and Vincent Racaniello
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The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: Arturo Casadevall
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Links for this episodeBrianne – The Ocean’s Youngest Monsters Are Ready for Glamour Shots Alan – 7 Billion Humans Rich – 15 Fascinating Animal X-Rays From the Oregon Zoo Vincent – Respiratory pathogen trends
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: John Dennehy, Davida Smyth, and Monica Trujillo
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Links for this episodeDickson – 250,000 Dominoes Brianne – Using RT-PCR in COVID-19 Testing Rich – Beaded Lacewings Can Take Down Six Termites With A Single Fart Kathy – Tracking the COVID code Vincent – Administering vaccines to adults
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Alessandro Sette
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Links for this episodeAlan – The Disinformation Dozen report Rich – No needle, but the damage was done Kathy – Zinn art David Zinn Vincent – Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs
Listener PicksJustin – Finnish astrophotographer spends 12 years creating a Milky Way mosaic
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.
Hosts: Daniel Griffin and Vincent Racaniello
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Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld
Guest: Susan Weiss
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Links for this episodeBrianne – Tiktok of How mRNA Vaccines Work Alan – Dark Rich – Unmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217 Amy – MOMA Calder exhibit, reviewed in NYTimes Vincent – Ripple Training (free YouTube channel)
Listener PicksRuth – 100 million year old seafloor bacteria resuscitated Iradis – Linda Zall, CIA spy for science
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – 10 amazing science tricks with liquids Brianne – How Do Blind Worms See the Color Blue? Rich – Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children Kathy – Dark side of the moon as it crosses Earth Vincent – Wasdkeyboards and Novelkeys
Listener PickBronwen – COVID Performance Index
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker
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Links for this episodeIn COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeMatt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Matt Frieman
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Links for this episodeDickson – Covid-19 deaths per million ranked by average income Brianne – KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard Rich – The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’(wiki) Kathy – Quadrantid meteor (Quadrantids) Vincent – Higher Superstition by Paul Gross and Norman Levitt
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Wild animal photos Brianne – Greater than COVID Alan – WHO report on infodemic response Rich – Reference Guide to the International Space Station Vincent – 3D Molecular Designs
Listener PicksLisbeth – Have the new jab Karen – Cholera exhibit at Museum of Trades and Crafts
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler
Guest: Janet Iwasa
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Links for this episodeBrianne – How T cells see SARS-CoV2 Rich – Ice bubbles in Lago Bianco, Switzerland Kathy – Music in COVID-19 control tents Vincent – Perseverance runs on processors used in 1990s iMacs
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Eva Harris and Janet Smith
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Links for this episodeAlan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset
Listener PicksMatthew - Remembering the colleagues we lost to COVID-19 Lori - Iceberger
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Ginger Campbell, MD
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Links for this episodeDickson – Soapbox Gallery Brianne – Cell Picture Show Rich – Perseverance Rover’s Descent and Touchdown on Mars (Official NASA Video) Vincent – Our World in Data (see COVID-19 vaccinations)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – What is the polar vortex? Brianne – Cloning of the black-footed ferret Alan – Explaining mRNA vaccines with Star Wars Rich – Brighton Collaboration (BRAVATO); Ad26 vector template Kathy – Target public health ads to zipcodes Vincent – And Then the Gorillas Started Coughing
Listener PickKim – Virus getting the shot (jpg)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Paul Offit
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Links for this episodeDickson – Life in a Day 2020 Brianne – Microcosms in Glass Alan – NEJM article on promoting vaccination, interview with lead author Rich – The Microbescope Vincent – Autism’s False Prophets by Paul Offit
Listener PickEarl – Science is Real Pins
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Do scientists read enough fiction? Rich – Insects in flight; Insect flight|Capturing takeoff Kathy – Badger seal Vincent – MicrobeTV merchandise
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Paul Bieniasz and Theodora Hatziioannou
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Links for this episodeDickson – Mars Perseverance Rover Alan – The Outlaw Ocean Rich – Anand Varma Photography Vincent – Virology Lectures 2021
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – How the Body Reacts to Viruses Rich – How do wombats poop cubes? Kathy – The Verse by the Side of the Road Vincent – Janet Iwasa’s SARS-CoV-2 entry animation
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
Guest: Jason McLellan
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Links for this episodeDickson – Pandemic Pivot and Tuba Skinny Alan – Technological challenges in vaccine rollout Rich – I was lucky to find this vaccine anywhere Vincent – Lady Gaga’s MIXED METER Star Spangled Banner?!
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Spelling Bee Brianne – He Made a Viral Bernie Meme Site. Now He Has to Keep it Going Alan – America’s Cup AC75 capsize and aftermath in qualifying race Rich – Game Theory’s UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines Vincent – Top Science Podcasts
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episodeKathy – 15 YouTubers play Telestrations Vincent – Vince Beiser
Listener PicksBob, David, Janet – Sea Shanty by A Cappella Science (YouTube, TikTok, Bandcamp)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – Photos of mob attacking Capitol Brianne – Video of Neutrophil Phagocytosis Alan – Fishing Through the Apocalypse Rich – A Word on Statistics by Wislawa Szymborska Vincent – Letters from an American
Listener PickMike – Have the new jab
Intro music is by Ronald Jenkees
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – We Know Almost Nothing About Giant Viruses Rich – The Coccolithophores Project Kathy – v-safe and Vaccine Handbook Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 (pdf)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Emily Travanty
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Links for this episodeDickson – Randal Despommier on saxophone Brianne – Giant Microbes SARS-CoV2 Alan – West of Loathing Rich – Draft landscape of COVID-19 candidate vaccines Vincent – SARS-CoV-2 spillover events
Listener PickDaniel – His Vaccine Story Inspired His Father To Write A Disney Classic
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Linsey Marr on masks Kathy – Striped Martian Sand Dunes and Rich – How Microwaving Grapes Makes Plasma Vincent – Musings of an anonymous, pissed off virologist
Listener PickLaura – Auld Lang Syne follow-up
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeDickson – Best of 2020 by NASA and The Plague Year Brianne – Where Year Two of the Pandemic Will Take Us Alan – Japan’s distinct form of vaccine hesitancy Kathy – Paul Offit updates on the vaccine rollout and Choral Scholars of University College Dublin (John Greene’s videoessay on the song) Rich – Do You Love Me? Vincent – Story on Katalin Kariko’s career
Listener PickLouise – Virus socks
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Ready Player Two Kathy – Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine Rich – Boston Dynamics running robots Vincent – Fever by John Fuller
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.
Host: Vincent Racaniello
Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – EM Rap Podcast COVID update Kathy – Conjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus Rich – Chicken LIttle (wiki) Vincent – virological.org
Listener PickGreg – Someone who wants to make a difference Uli – XKCD on statistics
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – 2020 Audubon Photography Winners Brianne – COVID-19 Changed Science Forever Alan – Entangled Life by Merlin Sheldrake Rich – Lie of the Year: Coronavirus downplay and denial; John 18:38 Vincent – How New York City Vaccinated 6 Million People in Less Than a Month (my article from 2009)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Fears of a ‘Twindemic’ Recede as Flu Lies Low Kathy – Faculty Equity & COVID-19 UM ADVANCE Rich – ‘Sistine Chapel of the ancients’ rock art Vincent – Winners of ASM Agar Art Contest 2020
Listener PickJohnye – 2020 Year of the Vax t-shirt (and more)
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeDickson – 2020 In Photos: A Year Like No Other Brianne – Cooking for Geeks Alan – On Food and Cooking Rich – NASA Artemis (Wiki) Vincent – The virus, the bats, and us
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Laura Splan
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Links for this episodeBrianne – Patterns for Virus snowflakes Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter Rich – New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki) Vincent – The Right Stuff
Listener PickMiikael – Tiny tweak behind COVID-19 vaccines
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Amy Rosenfeld
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Links for this episodeDickson – National Geographic best animal photos of 2020 Amy – American Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt Alan – HamSCI citizen science organization Rich – DeepMind’s AI makes gigantic leap in solving protein structures Vincent – Army Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Pedromics Kathy – Global map at Mars opposition Rich – Janeway’s Immunobiology Vincent – Janet Iwasa’s Animation Lab
Listener PickCheryl – BioRender.com holiday card templates
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Peter Hotez
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Links for this episodeDickson – The World’s First Energy-Positive Hotel to Open in Norway Brianne – The Food Lab: Better Home Cooking Through Science Alan – ACIP’s ethical principles for COVID-19 vaccine allocation Rich – The Mandolorian Vincent – T. rex and the Crater of Doom by Walter Alvarez
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.
Hosts: Daniel Griffin and Vincent RacanielloSubscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Types of Scientists Coloring Book Kathy – South Pole video Rich – Steve Jobs by Walter Isaacson Vincent – Screenology (I interviewed Deb Sklut here)
Listener PickMona – Ad5 vector and podcast with ImmunityBio founder
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Shane Crotty
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Links for this episodeDickson – Benoit Mandlebrot’s 96 birthday Brianne – #BlackinImmunoWeek Rich – GoISSWatch ISS Tracking; Spot The Station (NASA) Vincent – Microbes Rule
Listener PickAgda – Sandwalk
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne – Picture a Scientist Kathy – Colors of the Moon and Word that hasn’t changed Rich – NASA YouTube channel Vincent – Laura Splan science art
Listener PickMona – Ad5 vector and podcast with ImmunityBio founder
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.
Hosts: Vincent Racaniello and Rich Condit
Guest: Kate Rubins
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne BarkerGuests: Daniel Griffin and Kathleen A. Crowley
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Links for this episodeDickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – Ring Fit Adventure Rich – BUGSS Baltimore Underground Science Space Vincent – Trilobite glassworks
Listener PickGina and Joe – COVID Fan Tutte
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.
Hosts: Vincent Racaniello, Rich Condit, and Brianne BarkerGuests: Mady Hornig, Fiona Lowenstein, and David Tuller
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Links for this episodeIntro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne BarkerGuests: Daniel Griffin and Amy Rosenfeld
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Links for this episodeDickson – CNN News Amy – I voted and Grace for President Alan – The Story of More by Hope Jahren Rich – OSIRIS-REx and 101955 Bennu Vincent – The Vexed Muddler
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Nels Elde
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Links for this episodeKathy – Why art is important and Tagging an asteroid Rich – Vendee Globe Vincent – PrePubMed
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.
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Links for this episodeDickson – Comedy Wildlife Photography Brianne – Ed Yong – Science reporting during a pandemic Alan – Tree Story by Valerie Trouet Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – Wearing is Caring
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episodeBrianne – Kids Meet a Virologist Kathy – Harvard glass marine invertebrates 3D online Rich – Chernobyl fungi Vincent – Artologica
Listener PickJustin – Totally Under Control
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episodeDickson – Nikon Small World Photography Competition Brianne – Modeling Herd Immunity for measles Alan – Small Gods by Terry Pratchett Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – The Twenty-One Balloons by William Pene du Bois
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Lisa Gralinski
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Links for this episodeBrianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy – Dr. Boyd the Chemist one and two GREAT short videos one and two, How to read an old school thermometer, New Marvel storyline Wear a Mask parody of Be My Guest Rich – Clear+Vivid with Alan Alda Vincent – Immune 36: Aberrant immunity in COVID-19
Listener PickRyan – Dr. Fauci on politicization of pandemic
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells.
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Links for this episodeDickson – The Age of Nature Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine Rich – 6th Annual Science Mill Benefit Vincent – The Evolution of Infectious Disease by Paul Ewald
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Ari Kozik and Kishana Taylor
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Links for this episode
Weekly Science Picks
Brianne - A Lab of One's Own by Rita Colwell Kathy – Endonym map Rich - “The Coronavirus Unveiled” by Carl Zimmer Vincent - Principles of Virology 5th Edition
Listener Pick
Les - Coronavirus cake Mary - Choir finds a way to sing
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guests: Daniel Griffin and Amy Rosenfeld
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Weekly Science Picks
Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts Alan - Lost Prologue Rich -RAPS COVID-19 vaccine tracker Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Kizzmekia Corbett
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Weekly Science Picks
Brianne - COVID-19 in Molecular Detail for Teaching Kathy – Mars shining brightest since 2003 Rich - Lost Prologue Vincent - Girl from Ipanema is weirder than you thought
Listener Pick
Sandra - Learn Medical Research
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks.
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett
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Links for this episode
Dickson - Why we should all wear masks Brianne - Milestones in Vaccines Rich - Wallpaper/fabric designs by David Goodsell Vincent - Das Coronavirus bullet points and a new t-shirt
Listener PickJustin - COVID Alert NY App | Department of Health
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Tony Schountz
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Weekly Science Picks
Brianne - Virus Masks Kathy – UV in the vineyards (video) Rich - Great White Shark Attack Vincent - Smart WiFi garage door opener
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Daniel Griffin
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Weekly Science Picks
Dickson - Rewilding Europe Alan - How to Do Nothing by Jenny Odell Rich - Gene drive engineered mosquitoes Vincent - TWiEVO 60 with 12 guests!
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: David Brenner
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode
Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.
Host: Vincent Racaniello
Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou
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Links for this episode
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Ralph Baric
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Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Intro music is by Ronald Jenkees
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Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Christian Drosten
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit
Guest: Daniel Griffin
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Intro music is by Ronald Jenkees
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Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove
Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.
Hosts: Vincent Racaniello and Rich Condit
Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer
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Intro music is by Ronald Jenkees
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Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Adam Kucharski
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Denise Esposito
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Intro music is by Ronald Jenkees
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In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Weekly Science Picks
KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger
Intro music is by Ronald Jenkees
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Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses.
Host: Vincent Racaniello
Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees
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In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD Rich - Mars in 4K
LIstener PickChristiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten Jon - The Logic of Doomsday
Intro music is by Ronald Jenkees
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From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.
Hosts: Vincent Racaniello and Rich Condit
Guest: Eugene Koonin
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Intro music is by Ronald Jenkees
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In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Intro music is by Ronald Jenkees
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From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.
Hosts: Vincent Racaniello and Rich Condit
Guest: Bernie Moss
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees
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Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness.
Hosts: Vincent Racaniello and Rich Condit
Guest: Dr. Anthony Fauci
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Dr. Fauci was previously on TWiV 219
Intro music is by Ronald Jenkees
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Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Michael Mina
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Intro music is by Ronald Jenkees
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Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more.
Host: Vincent Racaniello
Guest: Erling Norrby
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch
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In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Intro music is by Ronald Jenkees
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From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.
Host: Vincent Racaniello
Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees
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TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
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Intro music is by Ronald Jenkees
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From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.
Host: Vincent Racaniello
Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees
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Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Intro music is by Ronald Jenkees
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From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission.
Host: Vincent Racaniello
Guest: Lee Ching Ng
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Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
Guests: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees
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Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email.
Hosts: Vincent Racaniello and Rich Condit
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Intro music is by Ronald Jenkees
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Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore.
Host: Vincent Racaniello
Guests: Leo Yee-Sin and Nancy Tee
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric
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Intro music is by Ronald Jenkees
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Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.
Hosts: Vincent Racaniello and Rich Condit
Guest: Frederick A. Murphy
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.
Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein
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Intro music is by Ronald Jenkees
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Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak
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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Emmie de Wit
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.
Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Intro music is by Ronald Jenkees.
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Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Jon Yewdell
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Links for this episodeIntro music is by Ronald Jenkees.
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Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Raul Rabadan
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Links for this episodeIntro music is by Ronald Jenkees.
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From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.
Hosts: Vincent Racaniello
Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees.
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Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episodeIntro music is by Ronald Jenkees.
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Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.
Hosts: Vincent Racaniello
Guests: Peter Daszak
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Daniel Griffin
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Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episodeIntro music is by Ronald Jenkees.
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From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.
Hosts: Vincent Racaniello
Guests: Richard Hatchett and Linfa Wang
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Michael Schmidt
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeIntro music is by Ronald Jenkees.
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Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Susan Weiss
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Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.
Hosts: Vincent Racaniello and Rich Condit
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees.
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Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jeff Shaman
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Links for this episodeIntro music is by Ronald Jenkees.
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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees.
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Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric, Mark Heise, and Nat Moorman
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Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.
Host: Vincent Racaniello
Guest: Kostya Chumakov
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Links for this episodeIntro music is by Ronald Jenkees.
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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees.
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Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Stanley Perlman
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Links for this episodeIntro music is by Ronald Jenkees.
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Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.
Host: Vincent Racaniello
Guest: Christian Drosten
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Links for this episodeIntro music is by Ronald Jenkees.
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Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Links for this episodeIntro music is by Ronald Jenkees.
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Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: Doris Cully
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Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler
Guest: Daniel Griffin, MD
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Links for this episodeIntro music is by Ronald Jenkees.
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Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jon Yewdell
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Intro music is by Ronald Jenkees.
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TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episodeIntro music is by Ronald Jenkees.
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Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.
Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Daniel Griffin, MD
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Links for this episodeIntro music is by Ronald Jenkees.
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Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.
Hosts: Vincent Racaniello
Guest: W. Ian Lipkin
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Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.
Hosts: Vincent Racaniello
Guest: Mark Denison
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Intro music is by Ronald Jenkees.
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A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno
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Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Ori Lieberman
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Links for this episodeIntro music is by Ronald Jenkees.
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Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic.
Hosts: Vincent Racaniello
Guest: Stephen Morse
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Intro music is by Ronald Jenkees.
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Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.
Hosts: Vincent Racaniello
Guest: Ori Lieberman
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Intro music is by Ronald Jenkees.
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Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Ralph Baric
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The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy.
Host: Vincent Racaniello
Guests: Daniel Griffin and Valeria Cagno
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Intro music is by Ronald Jenkees.
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Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.
Hosts: Vincent Racaniello and Rich Condit
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The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Videocasts Day 1 Day 2
Listener PicksStephen - This podcast will kill you Neva - China's surveillance Sophia - WHO online courses
Intro music is by Ronald Jenkees.
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Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks.
Hosts: Vincent Racaniello and Rich Condit
Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver
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In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne
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Links for this episodeBrianne - Mutation, Adaptation, and Virus Genomes Alan - The Comet Rich - Finding Your Roots: Science Pioneers Dickson - Let’s Fill Our Cities With Taller, Wooden Buildings Vincent - Twenty-first century plague by Thomas Abraham
Listener PickMark - Tracking CoV infections Sophia - Legislative approaches to immunization
Intro music is by Ronald Jenkees.
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The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Pandemic Alan - Educated by Tara Westover Rich - Star Trek: Picard Dickson - Highest Resolution Image Ever Taken of Surface of the Sun Kathy - Scientists make vampire bats ‘glow’ to simulate vaccine spread Vincent - Virology Lectures 2020
Listener PickEdward - Virus snowflake designs Anthony - Microbe Hunting Autism to Zika
Intro music is by Ronald Jenkees.
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Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler
Guest: Ralph Baric
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Links for this episodeAlan - Library plug-in for Firefox or Chrome Rich - Sounds of the Solar Wind (Parker Solar Probe) Dickson - Stunning wildlife photos Kathy - Incomplete list of things that blow the minds of intro bio students Vincent - Mosquito photographs by Alex Wild (and anti-pick)
Listener PickJustin - YadaYadaYada virus
Intro music is by Ronald Jenkees.
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Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.
Hosts: Vincent Racaniello and Rich Condit
Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh
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Intro music is by Ronald Jenkees.
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TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne BarkerDownload TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeRich - Mayo Clinic - Ken Burns; Patient Care and Health Information Dickson - Australia Fires; Insect ecology; Smoke and aerosols Kathy - runcible Vincent - Without a Vaccine, These Are Your Odds
Intro music is by Ronald Jenkees.
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For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody Alan - “Yah! Yah! Yah!” by Jack London, and the true story it’s based on Dickson - Why whales are big but not bigger Kathy - Dual Axis Illusion Vincent - The Fall of the Faculty by Benjamin Ginsberg
Listener PickSuellen - Patient Zero podcast
Intro music is by Ronald Jenkees.
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From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication.
Hosts: Vincent Racaniello and Rich Condit
Guest: Chris Sullivan
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Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases.
Host: Vincent Racaniello
Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma
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Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available.
Host: Vincent Racaniello
Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial.
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Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization.
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From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health.
Host: Vincent Racaniello
Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic
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From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate.
Hosts: Vincent Racaniello, Rich Condit, and Nels Elde
Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden
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From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more.
Hosts: Vincent Racaniello
Guest: Paula Stephan
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William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: William Summers
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Links for this episodeAlan - Restoration of Western Flyer Rich - Purification of phage T7 RNA polymerase Dickson - The Galaxy is Not Flat Bill - Efficacy of tetravalent dengue vaccine Vincent - Blowout by Rachel Maddow
Intro music is by Ronald Jenkees.
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Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Amy Rosenfeld
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Links for this episodeAmy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore
Listener PicksAnonymous - Spill the Beans vaccinated shirts
Intro music is by Ronald Jenkees.
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The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - The Machinery of Life by David Goodsell Alan - Pomological watercolors Dickson - Wildlife Photographer of the Year Kathy - DiversifyMicrobiology DiversifyImmunology and Marmot becomes fox food Vincent - Burnet A Life by Christopher Sexton
Listener PicksJustin - Worm with three sexes
Intro music is by Ronald Jenkees.
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At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.
Hosts: Vincent Racaniello
Guests: Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte
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The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episodeBrianne - Retraction of new CCR5/lifespan study Alan - Nomad Press illustrated science books, and illustrator Lex Cornell Dickson - RARE: Creatures of the Photo Ark Vincent - The Odyssey of Eradication by Thomas Abraham
Listener PicksJustin - Mass spec pen Mark - What really brought down the Boeing 737 Max?
Intro music is by Ronald Jenkees.
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Hosts: Vincent Racaniello
Guests: Jan Albert, Petter Brodin, and Anna Smed-Sörensen
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The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - History of infectious disease before/after vaccines Alan - NIH Ham Radio Club Rich - Renewable jet fuel from air Dickson - Newly Discovered Comet Is Likely Interstellar Visitor Kathy - How professors spend their time Vincent - Non-polio enterovirus surveillance network
Listener PicksAlexey - Periodic Table Podcasts and Videos
Intro music is by Ronald Jenkees.
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The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Kiki Warren
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Links for this episodeAlan - Astronomy photographer of the year Rich- Urban living leads to high cholesterol... in crows Kiki- Reversal of epigenetic aging Vincent- General Virology by SE Luria
Listener PicksSindhu - Sweden Solar System Anthony- Surprising role of viruses in evolution with Eugene Koonin Paul- The Obscure Virus Club
Intro music is by Ronald Jenkees.
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From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses.
Hosts: Vincent Racaniello
Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg
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From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses.
Hosts: Vincent Racaniello
Guest: Erling Norrby
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David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS.
Host: Vincent Racaniello
Guest: David Tuller
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Intro music is by Ronald Jenkees.
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The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Why we need to increase diversity in the immunology research community Alan - Stock photos of vaccination that don’t suck Kathy- Sample size calculator Vincent- How Economics Shapes Science by Paula Stephan
Listener PicksMelinda - Zome Tools
Intro music is by Ronald Jenkees.
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TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln
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The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episodeBrianne - Deaf student makes sign language terms to communicate science Alan - Show Your Stripes Vincent- Sixty Years of Discovery
Listener PicksEric - This drug could end HIV - why hasn't it?
Intro music is by Ronald Jenkees.
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From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations.
Host: Vincent Racaniello
Guests: Alan Embry, Florian Krammer, and Jennifer Nayak
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The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - DukeMed Distinguished Award: Bill Joklik Alan - Audubon photography awards for 2019 Rich - Joklik paper on vaccinia virus mRNA; Joklik MEM Dickson- Ghost orchid pollination revealed Kathy- Crocheted petri plates Vincent- Documents relating to history of ASV
Listener PicksNeva - What happens if we engineer a superbug?
Intro music is by Ronald Jenkees.
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From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Sid Grossberg and Pat Spear
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From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic.
Hosts: Vincent Racanielloand Ben Berkhout
Guests: Ron Fouchier, Rosina Girones, and Marie-Paule Kieny
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TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Foldable viral capsid models and Foldable models demonstrate T numbers Alan - Laws Guide to Nature Drawing and Journaling Dickson- NASA 50th Events Kathy- Alta Obscura’s 17,069 strange and wonderful places Vincent- TWiEVO 44: The enemy of my enemy is my phage
Listener PicksAnthony - Global Water Pathogen Project
Intro music is by Ronald Jenkees.
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From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology.
Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager
Guest: Craig Cameron
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A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole.
Hosts: Vincent Racaniello, Kathy Spindler, and Alan Dove
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Links for this episodeAlan - Stephanie Langel’s Discovery Talk Kathy- Map of languages in the USA Vincent- Grad student mental health with Susanna Harris video and on TWiM 199
Listener PicksFernando - Pushing back on hyped-up science
Intro music is by Ronald Jenkees.
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Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines.
Host: Vincent Racaniello
Guest: David Oshinsky
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Intro music is by Ronald Jenkees.
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Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Kiki Warren
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Links for this episodeAlan - Seek Rich - Want to See My Genes? Get a Warrant and NIH director will no longer speak on all-male science panels Brianne- Unique scientists Dickson- Vaccines - Calling the Shots Vincent- NY eliminates religious vaccine exemptions and Jessica Biel reveals that she does not understand vaccines Kiki- Converting type A to type O blood
Listener PicksJustin - An Apple a Day
Intro music is by Ronald Jenkees.
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At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim.
Host: Vincent Racaniello
Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka
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Intro music is by Ronald Jenkees.
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TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes.
Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeAlan - Quabbin Reservoir Rich - Katherine Swan Ginsburg Humanism in Medicine Program; The Arnold P. Gold Foundation Brianne- UPitt Measles Simulator Dickson- James Webb Space Telescope Vincent- Nobel Prizes and Life Sciences by Erling Norrby
Intro music is by Ronald Jenkees.
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Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Kartik Chandran and Rohit Jangra
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Links for this episodeThis episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.
Weekly Science PicksAlan - Temi and Trint Rich - Using Jupiter's moons to determine where on Earth you are Kathy- Best architecture in every state Vincent - Cyberwire Podcast: The Ghost and the Mole Kartik- Slack Rohit- Antibody responses to viral infections
Intro music is by Ronald Jenkees.
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Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses.
Hosts: Vincent Racanielloand Marion Koopmans
Guests: Martin Beer, Stephan Gunther, and Vera Ros
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Links for this episodeThis episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.
Intro music is by Ronald Jenkees.
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Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses.
Host: Vincent Racaniello
Guests: Cara Pager, Rachel Netzband, and Alex Ciota
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Links for this episodeThis episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.
Intro music is by Ronald Jenkees.
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The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.
Weekly Science PicksAlan - Plots of Data visualization tool Rich - How to control the brain; Meet UF Physician Kelly Foote, MD Dickson- Oceanix Kathy- Iceproofing large structures Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo
Listener PickJohyne- NYTimes Mag Lab (sorry, no link) Sheena - History of Vaccines by NPR
Intro music is by Ronald Jenkees.
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Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
Guest: Jens Kuhn
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Links for this episodeJens - Forvo pronunciation guide Brianne -How long do vaccines last? Alan- How much hotter is your home town than when you were born? Dickson- 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner
Intro music is by Ronald Jenkees.
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The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy- Preventing airborne disease (video and primary article) Vincent - The Mueller Report
Listener PickSteve- Vaccine Mythbusting Cyprian- Ten simple rules towards healthier research labs
Intro music is by Ronald Jenkees.
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The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - How to Take a Picture of a Black Hole Alan- Jupiter Marbleimage Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut Dickson- Sky-High Stunners Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource
Listener PickMartin- Sydney Brenner passes
Intro music is by Ronald Jenkees.
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Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.
Host: Vincent Racaniello
Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein
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Links for this episodeIslam- How to successfully collaborate with industry
Intro music is by Ronald Jenkees.
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The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeAlan- Where and when to see cherry blossoms Dickson- Nebraska floods Kathy- Peeps fungal infection experiment Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces
Listener PickSam- STLR conversations Josh- Tree of Life
Intro music is by Ronald Jenkees.
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The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler
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Links for this episodeAlan- The Quarters Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video] Dickson- How rats became an inescapable part of city living Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses Vincent - Why “chickenpox parties” are a terrible idea—in case it’s not obvious
Intro music is by Ronald Jenkees.
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The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Why Do So Many Scientists Want to be Filmmakers Alan- Better boarding method airlines won’t use Dickson- Mass timber building Kathy- What organisms to study flow chart Vincent - World Pulls Andon Cord on 737 MAX
Listener PickRichard- The Real Cost of Knowledge Islam- 200 icosahedral viruses poster Mike- Post-Doc Me Now
Intro music is by Ronald Jenkees.
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TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Wendy Mauryand Stanley Perlman
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Links for this episodeIntro music is by Ronald Jenkees.
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The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Yes, I'm a Scientist on Twitter. Stop Judging Me. Alan- Impact of vaccines, graphed in heat maps Dickson- Treehoppers Kathy- World watershed maps Rich- Gene Machine by Venki Ramakrishnan Vincent - House hearing on measles outbreak (ASM comment)
Listener PickJordan- Facebook may remove anti-vaccine recommendations
Intro music is by Ronald Jenkees.
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Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals.
Hosts: Vincent Racaniello and Alan Dove
Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episodeBrianne - Hotel Influenza Alan- Your town’s climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich- NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes
Listener PickAnne- Pathogenesis II Kickstarter
Intro music is by Ronald Jenkees.
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The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - The Red Queen's Race Card Game Alan- Pentax Papilio II Dickson- Felice Frankel on improving visual side of science Kathy- History of the alphabet chart (free download) usefulcharts.com (see blog, such as Latin Greek Cyrillic Venn Diagram) Vincent - Virology Lectures 2019
Listener PickPeter- Microbehunter (YouTube, blog, forum)
Intro music is by Ronald Jenkees.
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The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Trying Polar Vortex Experiments at Home Rich- Three Identical Strangers Kathy- Science wear, especially for Valentine’s Day (discount) Vincent - State of anti-vaccine movement in US and Top 10 Health Threats for 2019
Listener PickAmy- If government can't deliver safe vaccines, is it fit to rule? Ted- Understanding Economics of Microbial Threats (pdf)
Intro music is by Ronald Jenkees.
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The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Retraction Watch database Rich- “The Mayo Clinic: Faith Hope Science” by Ken Burns Kathy- U-M EEB Photographer at Large contest Vincent - Vaccines: An achievement of civilization
Listener PickDavid- Useless Knowledge Begets New Horizons
Intro music is by Ronald Jenkees.
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Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Patrick Moore
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Links for this episodeBrianne – The herd to the rescue Alan – Magic Wings Butterfly Conservatory Dickson – 100,000 Genomes Project Kathy – Your Age on Other Worlds Vincent – Vitamin D and Prevention of Cancer and Cardiovascular Disease Pat – North Korea and Bioweapons
Listener PickEric – The Molecular Basis of Life
Intro music is by Ronald Jenkees.
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Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Steve Goff
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🎼 They’ll histone you when you start to transcribe, And they’ll histone you just for tryin’ to get by, So be careful when you uncoat your genome, ‘Cause everybody must histone.
Links for this episodeAlan - The Tangled Tree by David Quammen Dickson- Ammonia could power the globe Kathy- Portmanteaux and A.Word.A.Day Vincent - Curioscity Steve- Alice and Bob Meet the Wall of Fire
Listener PickChaim- Tony Fauci on getting your flu vaccine (mp3)
Intro music is by Ronald Jenkees.
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At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager.
Host: Vincent Racaniello
Guest: Roland R. Rueckert
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Links for this episodeIntro music is by Ronald Jenkees.
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In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Pandemic Trail game Rich- On a Bat’s Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers
Listener PickAnne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf)
Intro music is by Ronald Jenkees.
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The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom
Listener PickNeal- The Yoda of Silicon Valley
Intro music is by Ronald Jenkees.
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The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler
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Links for this episodeAlan - Population mountains to visualize cities Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy- NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap
Listener PickNeal- Was a Scientist Jailed?
Intro music is by Ronald Jenkees.
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Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism.
Host: Vincent Racaniello
Guest: Peter Hotez
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Links for this episodeIntro music is by Ronald Jenkees.
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Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michelle Flenniken
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Links for this episodeMichelle - First 21 days of a bee's life; NPR's Hidden Brain; Varroa destructor triggers deformed wing virus in bees Brianne - Flu Near You Alan - Skype a Scientist program Rich- NASA's Voyager 2 Probe Enters Interstellar Space Kathy- Which ones are bees? And What it feels like to be a bee Vincent - Fecal sequencing and Vaccines did not cause Rachel's autism by Peter Hotez
Intro music is by Ronald Jenkees.
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Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.
Hosts: Vincent Racaniello and Amy Rosenfeld
Guest: Raul Andino
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Links for this episodeAmy - Insectropolis Vincent- Genome-edited baby
Intro music is by Ronald Jenkees.
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At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.
Hosts: Vincent Racaniello
Guests: Cornel Fraefel, Urs Greber, and Silke Stertz
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - $40 internationally standard cup of tea Rich- Mars InSight Mission Dickson- New York Botanical Garden Train Show Kathy- Comedy wildlife photo awards finalists Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research
Listener PickFernando - Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin
Intro music is by Ronald Jenkees.
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Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Why don't we have vaccines against everything? Rich- Golden Globe Race Dickson- The Anatomy of Figure Drawingby Robert Demarest and Warder Clyde Allee Kathy- Orientation of the moon’s appearance, Southern Hemisphere Vincent - Paul has Measles in English and Spanish
Intro music is by Ronald Jenkees.
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The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Nebula Genomics: a new start-up offering free genome sequencing (with a catch) Alan- GRE scores are poor predictorof degree completion Rich- The Science Mill(video) Dickson- The 12 cranial nerves (mnemonic) Kathy- NAS report on Sexual Harassment of Women (free pdf) Iceberg figure Vincent - The Tangled Tree by David Quammen and TWiEVO #37
Listener PickMark- Weekly US Map: Influenza Summary
Intro music is by Ronald Jenkees.
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The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeBrianne - Pandemic (board game) Alan- The Shortwave Radio Audio Archive (siteand blog) Rich- James Cook's First Pacific Voyage, 1768-1771 (interactive map) Dickson- The Scientist on Instagram Vincent - State of the World’s Fungi
Listener PickDavid- Bruno LaTour
Intro music is by Ronald Jenkees.
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Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.
Host: Vincent Racaniello
Guests: Nicholas Buchkovich and Leslie Parent
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Links for this episodeIntro music is by Ronald Jenkees.
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Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episodeBrianne - Ed Yong on AFM Vincent - Goggles Optional podcast (especially #243)
Intro music is by Ronald Jenkees.
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Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Leonid Yorkovetskiy and Jeremy Luban
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Links for this episodeBrianne - The Chimp and the River by David Quammen Rich- James Cook’s First Voyage Journal (20 sec Google Earth summary) Kathy- High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps) Dickson- Jellyfish Jeremy - Pictorial Guide to Living Primates; All The World's PrimatesLonya- Chougui et al. HIV-2/SIV Vpx counters HUSH Vincent - Research!America
Intro music is by Ronald Jenkees.
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The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeBrianne - Germ City-Microbes and the Metropolis Museum Exhibition Alan- Nikon 2018 Small World in Motion competition Kathy- Ion Torrent Sequencing (video) Dickson- 2018 Nobel Prizes Economics Kathy- Ocean-centric map Vincent - Intelligence Matters Podcast: Anthony Fauci on threats from epidemics
Listener PicksGonsalo - Cells at Work (Manga, Anime)
Intro music is by Ronald Jenkees.
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The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeAlan- Compound Interest chemistry graphics Kathy- Writing letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al. Dickson- Japan Fireworks Vincent - The Game of T-Cells and Apple Park Lego
Listener PicksSteve - Shomu's Biology
Intro music is by Ronald Jenkees.
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From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.
Host: Vincent Racaniello
Guest: Harry Greenberg
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Links for this episodeIntro music is by Ronald Jenkees.
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Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Brianne Barker, and Anne Simon
Click arrow to play Download TWiV 512 (62 MB .mp3, 103 min) Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episodeBrianne - Why are so many genes unstudied? (Zimmerand Yong) Alan - Unveiling the RNA World Rich - Spaghetti mystery solved (PNAS paper) Dickson - Science Fair Vincent - A PhD Lab Coat Ceremony
Listener PicksStephen - Flu vaccine myth rant by Crislip Jolene - Research Matters in PLoS Path and PLoS Biology Nicholas - Charity Matters app
Intro music is by Ronald Jenkees.
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Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Ned Landau
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Links for this episodeBrianne- Online Immunology Course Alan- Bacteria Builder Rich- 2018 Ig Nobel Prizes Dickson- Between Fear and Hope Ned - HUSH silencing of transposons Vincent - Paywall publishing ban (Schlitz statement); Curry on DORA
Listener PickSteve- Paywall: Business of Scholarship and Biohazard Islam- Peer review Twitter post
Intro music is by Ronald Jenkees.
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Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.
Hosts: Vincent Racaniello and Dickson Despommier
Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata
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Links for this episodeIntro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker
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Links for this episodeBrianne- Climate change visualization Alan- Anova sous vide cooker Dickson- Fire season in western US Kathy- Sunscreen in UV and The Projector Illusion Vincent - The Usefulness of Useless Knowledge
Listener PickRiver- The Conscience of the Present
Intro music is by Ronald Jenkees.
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Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Jens Kuhn
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Links for this episodeJens - Nudibranchs, Beastly Garden, large nidovirus (one, two) Rich - Living inside a canister Dickson - Global rivers and streamsKathy - TWiM 181 Dr. Warhol’s Periodic Table of Microbes Vincent - Twitter Bots and Russian Trolls Amplify Vaccine Debate
Intro music is by Ronald Jenkees.
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The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episodeAlan - Puzzled Escape Games Rich - An Extremely Detailed Map of the 2016 Election Dickson - Parker Solar ProbeKathy - Ancient earth globe and connected Dinosaur database Brianne - STEMM education should get HACD Vincent - Free tuition for all NYU medical students
Listener PickHeather- GoFarm blog
Intro music is by Ronald Jenkees.
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David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episodeAlan - Ebola research begins at the NEIDL Dickson - Science Photo Library Brianne - First liquid water (underground lake) found on Mars Vincent - Thirty years ago, we could have saved the planet
Listener PickEdmund- STEM talk
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
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Links for this episodeAlan - Impossible Burger Rich - SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions Dickson - Art and Science Intersection (Art Science Museum) Brianne - Why it is not a 'failure' to leave academia Kathy- 2003 video history of nuclear explosions 1945 - 1998 Vincent - Revisionist History Episode 8 and Episode 9
Listener PickMark- TWIV bingo (png)
Intro music is by Ronald Jenkees.
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The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episodeAlan - Glaciers of the Rockies aerial photos Rich - SpaceX CRS-15 mission to the space station(wiki) Dickson - Test of Einstein's theory of relativity Brianne - biorender Vincent - True or False? with Michael Schmidt
Listener PickJolene- Dogs cannot get autism
Intro music is by Ronald Jenkees.
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Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Svetlana Folimonova and Anne Simon
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jason Gill and Ry Young
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Links for this episodeIntro music is by Ronald Jenkees.
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Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.
Host: Vincent Racaniello
Guests: Sabrina Sholts, Jon Epstein, and Ed Niles
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Links for this episodeIntro music is by Ronald Jenkees.
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The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jinny Suh, Jason McClellan, and Jon Huibregtse
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Links for this episodeAlan - The Airplane Cabin Microbiome Rich - Coalition for Epidemic Preparedness Innovations (CEPI)(wiki) Dickson - The Big Five Mass Extinctions Kathy - Virus scarves at Red Bubble phage-specific variety Vincent - Science podcasts
Listener PickMaureen- 12 year old takes on Flint's Water Crisis
Intro music is by Ronald Jenkees.
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Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research.
Hosts: Vincent Racanielloand Alan Dove
Guests: Nathalie Grandvaux, Craig McCormick, Kate O'Brien, and Ryan Noyce
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Links for this episodeIntro music is by Ronald Jenkees.
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Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Stacy Hornerand Ken Stapleford
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Links for this episodeIntro music is by Ronald Jenkees.
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At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research.
Hosts: Vincent Racanielloand Rich Condit
Guests: Sasha Gorbalenya, Jim Hogle, Ann Palmenberg, and Frank van Kuppeveld
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Intro music is by Ronald Jenkees.
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Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction.
Hosts: Vincent Racanielloand Rich Condit
Guests: Stacey Schultz-Cherry, Douglas Diekema, and Andrew Noymer
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episodeAlan - National Cryptologic Museum Rich - Science is mostly about staring Dickson - New Zealand gloworms Kathy - Openingof Smithsonian Outbreak; conference advice General ASV Vincent - ICTV online
Intro music is by Ronald Jenkees.
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Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episodeAlan - Happy 35th birthday, PCR Kathy- Everything can be a speaker Vincent - Ocean rise due to rocks(debunked); Gates advises Trump on viruses
Listener PickNoah- David Baltimore on iBiology
Intro music is by Ronald Jenkees.
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The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Personal Finance for PhDsby Emily Roberts Kathy- Optical illusions fool artificial intelligence Rich- 2017-2018 snowfall graphic Dickson- Dust from the Sahara Vincent - The Last Days of Smallpoxby Mark Pallen
Listener PickIntro music is by Ronald Jenkees.
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The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Decline of local newspapers leaves epidemiologists blind Kathy- Journal oversight, mental health research Rich- The Big Sort: An Insider's Tour of a Recycling Plant Dickson- When Science Meets Art Vincent - A Crack in Creationby Doudna and Sternberg
Listener PickTom- Trillions Upon Trillions of Viruses Fall From the Sky Each Day
Intro music is by Ronald Jenkees.
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The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeAlan - Oligodendroglioma in song Kathy- Everything-repellent coating to grime proof phone screens & more Rich- Gaia star map Dickson- Clouds are complicated Vincent - Eradicating polio with a vaccine we must stop using
Listener PickStephen- Forget the Avengers, it took real heroes to make India polio-free
Intro music is by Ronald Jenkees.
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From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeKathy- Landscapes that look like another world (but they are from Spain) Rich - Brighton Collaboration; Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?) Dickson- Clouds of Jupiter and EBNA2 and autoimmunity Vincent - More than one-third of graduate students report being depressed (original article)
Intro music is by Ronald Jenkees.
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Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'.
Host: Vincent Racaniello
Guest: Sandra Urdaneta-Hartmann
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeKathy- Peak bloom and photographing cherry blossoms Dickson- Origins of vertebrate RNA viruses Alan- Rare footage of anglerfishin the deep ocean Vincent - NIH must reduce disparities in funding
Listener PicksMariann - Eden Project and Bellyvision Apparatus and the Like Amir- Winners of ICR Science Photography and Photography Contest
Intro music is by Ronald Jenkees.
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At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers.
Host: Vincent Racaniello
Guests: Dominique Carter, Sid Grossberg, John Kirby, Scott Terhune, and Vera Terakanova
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Intro music by Ronald Jenkees
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Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.
Host: Vincent Racaniello
Guest: Sean Whelan
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Links for this episodeIntro music by Ronald Jenkees
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The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeKathy - Vegas casinos lost money on physicists Brianne - Astronaut twin's DNA is not 7% different! Dickson - Parasitic Diseases lecture videos Alan - In Season blog by Donna Long Vincent - Buckyball viruses
Listener PicksPaul - Wine labels (front, back)
Intro music is by Ronald Jenkees.
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The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeKathy - How to read a phylogenetic tree Brianne - No immune overload for vaccines Dickson - Flowchart of viral families Alan - Letters to a Pre-Scientist Vincent - True believers, entrepreneurs, and scammers in alternative medicine and Simply Put: Vaccines Save Lives
Listener PicksVinayaka - Code of Ethics for Young Scientists Matt - TWiV 443
Intro music is by Ronald Jenkees.
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Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episodeKathy - Dance Dance Rich - Snopes Alan - Next Generation Science Standards Vincent - TWiEVO 28: Genetics of skin pigmentation in Africa
Intro music is by Ronald Jenkees.
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The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episodeKathy - Origami sound barrier Brianne - iBiology Dickson - Switched-on bats Alan - Hawaii’s communication breakdown Vincent - Inside the Federal Bureau of way too many guns and What I Saw Treating Parkland Victims
Listener PickJohnye - Debunking Anti-Vaxxers
Intro music is by Ronald Jenkees.
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The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - CD45.1 and CD45.2 mice may not be functionally equivalent Rich - Relative humidity versus dewpoint (video) Dickson - Underwater photography winners Alan - Photo of a single atom Vincent - Proposed Federal science budget cuts and The Blog is Dead
Listener PickJess - Louis Tompkins Wright
Intro music is by Ronald Jenkees.
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Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Scott Hensley
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Links for this episodeKathy - Flow Virometry Rich - Falcon Heavy Launch links: Flight diagram; Launch including booster landing; Tesla in space; Tesla orbit; Reusable booster failures; Booster size Dickson - Next generation of weapons Alan - Ed Yong’s story on fixing gender imbalance in science reporting Vincent - CD4 Hunter iOS Android
Intro music is by Ronald Jenkees.
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The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Great Lakes, false color Rich - Times 360 Lego factory tour Dickson - 3D printed houses Alan - The new terms for trust in journalism Vincent - A Tale of Two Cultures and Why Science Blogging Still Matters
Listener PicksJolene - Immune Quest
Intro music is by Ronald Jenkees.
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The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - UM EEB photo contest Rich - Dino-Lite digital microscope and digital microscope camera Dickson - Sandford Photography Alan - A list of female virologists Vincent - Virology Lectures 2018
Listener PicksAndrew - Interferome Neva - The Untreatable by Gavin Francis
Intro music is by Ronald Jenkees.
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The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Ice cliffs form over the weekend Rich - The Courage To Invent: A NASA Roboticist Tells Her Story (Ayanna Howard) Dickson - 2017 Was One of the Hottest Years on Record Alan - Experimenter gender and replicability Vincent - Set Your Autocorrect to Change 'Guys' to 'Folks'
Listener PicksAsal - 100 million chickens with avian flu Mark - Dr. Tatiana's Sex Advice to All Creation
Intro music is by Ronald Jenkees.
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Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Nels Elde
Click arrow to play Download TWiV 476 (63 MB .mp3, 105 min) Subscribe (free): iTunes, RSS, email
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Links for this episodeNels - Everyday Evolution Kathy - Paper-fold an ellipse Rich - Oxford Nanopore Technologies: YouTube channel; General technology; DNA sequencing; Sequencing singularity Dickson - Spiders that look like pelicans Alan - Guessing pool for China Spacelab reentry Vincent - How to take a picture of the stealth bomber over the rose bowl
Listener PicksGretchen - The Bearded Lady Project
Intro music is by Ronald Jenkees.
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In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeKathy - Voyager recording and book Rich - David Sheldrick Wildlife Trust (Maktao) Dickson - Global Croplands Map Alan - The Great Influenza one day at a time Vincent - The Doomsday Machine by Daniel Ellsberg
Listener PicksMark - Science Moms and Science of HIV Andy - Ask Me Anything Steve - Critical Attitude in Medicine
Intro music is by Ronald Jenkees.
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The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeKathy - Every second Dickson - Top 10 Science Images 2017 Alan - Shortwave Radiogram Vincent - Science March on Instagram
Listener PicksIslam - Class Crossword (Armored Penguin) Peter - The Last of the Iron Lungs
Intro music is by Ronald Jenkees.
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The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Today in Science History Dickson - 10 Breakthrough Technologies 2017 Rich - SpaceX to orbit a Tesla Alan - Debt in America Vincent - The Death of Expertise by Tom Nichols (NYTimes review)
Listener PicksStephen - A Concise Paper Johnye - Holiday song parodies (one, two, three) Tom - SMBC: Are viruses alive?
Intro music is by Ronald Jenkees.
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Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast.
Host: Vincent Racaniello
Guest: Ray Ortega
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Links for this episodeIntro music is by Ronald Jenkees.
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The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Google doodles Discoverer of photosynthesis Robert Koch Dickson - Nature Photography Winners Rich - The Raging Idiots Planet Song Alan - Zooborns Vincent - Glass Insects and Plants by Yuki Tsunoda
Listener PicksScott - Sagan Series Paul - SMBC Comics Trudy - If Scientists Wrote Christmas Songs
Intro music is by Ronald Jenkees.
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The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - NASA is reinventing the wheel Dickson - Stunning neuroscience images Rich - Moneyball by Michael Lewis (film) Alan - Diverse Sources Vincent - Zombie gene protects elephants from cancer (Quanta, TWiEVO)
Listener PicksScott - Why Vaccines Matter by Cynthia Gorney and The Song of the Dodo by David Quammen.
Intro music is by Ronald Jenkees.
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The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.
Weekly Science PicksKathy - Photo of 3200 year-old tree in one image Dickson - Microsculpture Rich - A Short History Of Humans And Germs Alan - Planets app Vincent - Laptops Are Great. But Not During a Lecture or a Meeting
Listener PicksBasel - Joint Pathology Center John - OpenStax
Intro music is by Ronald Jenkees.
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The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.
Weekly Science PicksKathy - Patterns Video (WonderLab) Dickson - Nikon 2017 Photomicrography Contest Rich - Leonardo Da Vinci by Walter Isaacson Alan - Sail Magazine Best Boats 2018 Vincent - Science Is Dry, Obscure, Complex?
Listener PicksBen - Is the staggeringly profitable business of scientific publishing bad for science?
Intro music is by Ronald Jenkees.
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Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Amy Rosenfeld
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Links for this episodeThis episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.
Hosts: Vincent Racaniello, Alan Dove,and Rich Condit
Guest: Jon Yewdell and Teddy Yewdell
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Links for this episodeThis episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.
Host: Vincent Racaniello and Kathy Spindler
Guests: Tuli Mukhopadhyay, John Patton, and Adam Zlotnick
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Links for this episodeIntro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Theodora Hatziioannou
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksTheodora - To Kill A Mockingbird by Harper Lee Kathy - 25 MILLION Orbeez in a pool Dickson - Fluid Dynamics of Paint Rich - The Hitchhiker's Guide to the Galaxy by Douglas Adams Alan - 30 days at sea: timelapse Vincent - TWiEVO 24 and Every Time Zone
Listener PicksFernando - Lego Women of NASA
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.
Host: Vincent Racaniello
Guests: Katya Heldwein and Sean Whelan
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksKathy - When biospheres collide Dickson - Blame 10 rivers for ocean plastic Alan - Farming in The Netherlands Vincent - Meet the Microbiologist
Listener PicksJay - OmegaTau podcast Trudy - Arrowsmith by Sinclair Lewis Mark - iOS app Human Anatomy Atlas and Master in Business podcast
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.
Hosts: Vincent Racaniello
Guest: David Tuller
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Links for this episodeIntro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.
Hosts: Vincent Racaniello
Guest: Phillip A. Sharp
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Brianne Barker
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksKathy -Best eclipse video (to date) and solargraph Dickson - Photos by Will Eades Brianne - Pale Rider by Laura Spinney Rich - “Supergenes” Drive Evolution Vincent -Anatomy of a Moral Panic
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.
Host: Vincent Racaniello
Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksKathy - Cassini photos Dickson - Caliber Biotherapeutics Alan - Grav Rich - Google street view of the International Space Station (article) Vincent - the bioinformatics chat
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksKathy - Antibody validation Editorial Asilomar meeting report Dickson - Despommierphotoart.com Alan - NOAA Hurricane Hunters Rich - Awakenings by Oliver Sacks (encephalitis lethargica) Vincent - Goodnight Lab by Chris Ferrie
Listener PicksPete - Change Agent by Daniel Suarez Paul - Pasteur's Gambit by Stephen Dando-Collins Maureen - Discovery Documentary First in Human
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Brianne Barker
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twiv.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksBrianne - 3D printed viruses Dickson - Secrets of Schooling Alan - Making sails in the Nevada desert Rich - David Vetter isolation suit (Wiki) Vincent - Confounds the Science
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.
Hosts: Vincent Racaniello and Rich Condit
Guest: Brianne Barker
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksBrianne - Up-Goer Five Challenge (related to Thing Explainer) Rich - The Farthest: Voyager in Space and Vipassana Momma: Science Vincent - Episode of Revisionist History: The Basement Tapes
Listener PickJennie - What Piece of Lab Equipment Are You?
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Erin Garcia
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Links for this episodeThis episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science PicksErin - What If? by Randall Monroe Rich - Art.Science.Gallery (J. Haley Gillespie) Kathy - Astronomy photographer of the year shortlist Alan - Upcoming Eclipses Vincent - Ford Thunderbird Automatic Transmission Rebuild
Listener PickBryan - Neuroscientists tricks journals
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guests: Sharon Isern and Scott Michael
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Links for this episodeDickson - Industrial Scars Kathy - Eclipse info by zipcode Sharon - Michaela’s article in The Conversation Scott - Signal P, Pecaan, Phamerator, DNAmasterAlan - The Eagle Whisperer” (and the Great Big Story channel) Vincent - Bottle
Listener PickKevin - Tenure track scientist bites the dust
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Diane Griffin
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Guest: Lynda Coughlan
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Links for this episodeKathy - US rivers as subway map Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot Alan - Apollo-era computers found in dead engineer’s basement Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental
Listener PickStig - Security Now! and The Gene by Siddhartha Mukherjee Ricardo - John Oliver on Vaccines
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Approaching Jupiter and Michigan parents about vaccination Rich - Math Limericks from Futility Closet Alan - NASA flyover of Pluto Vincent - Talk show host nominated as USDA chief scientist
Listener PickNeil - These smart girls are here to debunk anti-vaxxer nonsense John - John Sever AMA
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Ben tenOever
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Links for this episodeBen - Invisible Invaders by Peter Radetsky Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose Dickson - All the World's Earthquakes Alan - Map of Roman roads Vincent - Brain atlas of fly behavior
Listener PickRob - Vaccinate Your Kids and Charles Darwin Natural Selection Islam - Self-assembling virus and Virus Patterns
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episodeKathy - ASV 2017 Virolympics Crossword (pdf) Dickson - The Visible Mouse Alan - Is profitable publishing bad for science? Vincent - Locally Sourced Science
Listener PickNeva - Michael Summers interview and Virus coloring book
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Mavis Agbandje-McKenna
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This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life science industry. The company’s 3,500 products support scientists’ worldwide to advance their knowledge in genomics, proteomics, cellular analysis, drug discovery and human identification. Founded in 1978, the company is headquartered in Madison, WI with branches in 16 countries and over 50 global distributors.
Promega products are used by life scientists who are asking fundamental questions about biological processes applying their knowledge to diagnose and treat diseases or discover new therapeutics.
For more information about Promega, visit www.promega.com/ASV
Weekly Science PicksKathy - Doktor Kaboom! Dickson - Mars as you've never seen it before Alan - Eclipse 2017 Rich - Sirens of Titan by Kurt Vonnegut Vincent - Research!America
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Oskar Fischinger Google Doodle Dickson - Ten Tiny But Terrifying Micro Monsters Alan - Hunting mammoth ivory in Siberia Rich - Occam’s razor Vincent - Blame vax for illness without proof, says EU
Listener PickEd - Lysenkoism
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - BioKids Critter Catalog Dickson - Shanghai Vertical Farm Alan - Colossal Cave Adventure open source Rich - Life on Mars (HI-SEAS) Vincent - TWiM 154 with Arturo Casadevall
Listener PickGrant - Antibody validation challenges
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses.
Host: Vincent Racaniello
Guests: Margo Brinton, Luis Enjuanes, and Linda Saif
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space.
Hosts: Vincent Racaniello and Rich Condit
Guest: Kate Rubins
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Links for this episodeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episodeIntro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Science Showcase Video Contest Alan - Biochemical pathways on one chart Rich - 35th America’s Cup Vincent - Viruses (pdf) and A whole new Jupiter
Listener PickPeter - Fake typhoid epidemic saves Polish city and Life gets complicated when disease overruns your town Ralph - Dilbert on climate change
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Tim Requarth
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Links for this episodeKathy - Life Saver Lightning Alan - Model rocket engine burning in slow-mo Rich - scistarter Vincent - The quest to wipe out a virus and FCC Votes to Begin Dismantling Net Neutrality
Listener PickRobert - Zika presentation
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - Social science research on “luck” in motherhood Alan - Foiling dinghy built by engineering students (video) Rich - Human Exploration Research Analog (HERA) Vincent - Make measles great again in Michigan and Which tech giant would you drop?
Listener PickSteven - Difficult truths about a post-truth world
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episodeKathy - U-M Rubik’s Cube story #1 video #2 video #3 video Alan - You're not going to believe this Rich - High School student builds robot to solve Rubrik's cube Vincent - NIH limits grant money and The abomination of a bill
Listener PickKen - The Fab Lab with Crazy Aunt LindseyLaurel - Sally Hoskin’s CREATE programMaureen - Simple Science Experiments You Can Do With Eggs Before Breakfast
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Paul Bieniasz
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Links for this episodeKathy - UM Science Communication TeachOut Alan - LLNL nuclear test videos Rich - The Great A.I. Awakening (Artificial neural network; DeepDream; DeepDream images) Dickson - Cassini imagesPaul - Howard Hughes Medical Institute Vincent - Google rewrites search rankings; Senator Whitehouse on politics of climate change
Listener PickAnthony - Raspberry Pi 3 Model B Weather Monitor Kit
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Stefano Bertuzzi and Susan Sharp
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksAlan - Steve Ballmer’s government data project (NYTimes article) Rich - Alexander Hamilton by Ron Chernow Dickson - Shanghai vertical farming Vincent - Right-to-try sham and NASA mediaStefano - Why Religion is Natural and Science is Not and The Path Between the Seas Susan - Rick and Morty
Listener PickJohnye - A capella CRISPR/Cas9
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksKathy - Cloud appreciation society Rich - High Rise Urban Farming Dickson - Planets orbiting a distant star Vincent - TWiEVO 18: Raiders of the lost orco
Listener PickKevin - Cherry blossoms at Brooklyn Botanical Garden
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guests: Susan Daniel, Colin Parrish, and Gary Whittaker
At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksAlan - Couple donates insect collection Kathy - Why is science important to you? Rich - Hook Dickson - Ten Incredible Astronomy Pictures Vincent - Why Trump’s NIH Cuts Should Worry Us and The Real Threat to National Security: Deadly Disease
Intro music is by Ronald Jenkees.Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksAlan - The Wrath of Khan from Bug Chicks Kathy - Boaty McBoatface submarine launching Dickson - Fierce animal portraits Vincent - Westworld
Listener PicksHannah - Plague, Inc Stig - John Oliver: Trump vs the truth
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksAlan - Contact information for Senators and Representatives Kathy - How Tumor Virology Transformed Oncology Dickson - Seven new species of Peacock Spider Vincent - Proposed NIH budget cut and Expensive Oxford Comma
Listener PickKim - Pigeon Fashion Week (TWiEVO 7) Richard - aeroMorph and Understanding Molecular EvolutionJohnye - Ice Instruments and Fahrenheit and Celsius
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksAlan - Raspberry pi Kathy - The Worst F%ing Words Ever Dickson - NASA images of climate changeBrianne - How herd immunity works Vincent - Radioactive boars in Fukushima
Listener PickMargaret - DNA socks and gloves
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksRich - Germ Theory by Robert P. GaynesAlan - Student Scientist Partnerships Kathy - Symbiartic Dickson - PaleoBioDB Navigator Vincent - Kusama Infinity Room
Listener PickChaim - How to fight back against the backfire effect
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science PicksRich - Vipassana Momma (Dravet Syndrome) Kathy - Landlines Chrome Experiments Dickson - Origami Revolution Vincent - Hunched Over a Microscope
Intro music is by Ronald Jenkees.
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor
Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis.
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection.
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Weekly Science PicksAlan - Skulls Unlimited Rich - Bernard Moss Reflection Kathy - Why vaccines don't cause autism Dickson - Honomobo Vincent - Trump vs FDA
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Guest: Vincent Munster
At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses.
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Links for this episodeSend your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus.
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Weekly Science PicksAlan - Good Omen miniseries (book) Kathy - How to cure earworms Dickson - Exoplanets orbits Vincent - Outbreak News Today
Listener PickTom - The Smartest Protester
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells.
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Weekly Science PicksAlan - Deerland by Al Cambronne Dickson - Antarctica's Colorful Underwater World Kathy - You can’t unring a bell #1 and #2 Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki) Vincent - Trump Science Advisors, National Parks Won't Be Silenced
Listener PickStefan - The Vital Question by Nick Lane Kevin - Scientists March on Washington? Dennis - Fractal Tree of Life
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection.
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Weekly Science PicksAlan - Medical lab whirligig Dickson - Antarctica's Colorful Underwater World Kathy - Prince Rupert’s drops #1 and #2 Rich - Dylan's 30th - Eric Clapton --Don’t Think Twice, It’s All Right (The 30th Anniversary Concert Celebration) Vincent - Saving climate data and Public Good and Public Funding of Science
Listener PickSuellen - For the anti-vaccine people
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Trudy Rey
Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.
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Links for this episodeTrudy - Artist Jenni Viljaniemi Alan - Radio Garden Dickson - World's First Green Energy Boat Kathy - mSphereDirect video and web Rich - Deathworld Trilogy by Harry Harrison Vincent - Trump's Vaccine Panel (NYTimes), Offit's Response (Daily Beast), ASM Letter
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jared Rice
The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats.
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Links for this episodeAlan - GPS visualizer Dickson - James Webb Space Telescope and The Vertical Farm Kathy - First Snowflake Photos (One and Two) Rich - Red Mars by Kim Stanley Robinson Vincent - Carrie Fisher Fought for the Rebel Alliance and Mental Health Awareness
Listener PickKen - The Abate Lab Sean - The Death of Expertise
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.
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Should auld infections be forgotAnd never T-cells primed?Will cross-reacting antigensProtect the host next time?
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Weekly Science PicksAlan - North America's Lost Medieval City Dickson - New Views of Pillars of Creation Kathy - Reilly Top Ten Rich - Everyday Einstein Vincent - Naples' Sleeping Volcano Might Be Waking Up
Listener PickJohn - RadioLab: The Times They Are a-Changin'
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Nathan Letts
The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.
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Weekly Science PicksAlan - Open Access Button Dickson - National Geographic Photographs Kathy - World's Tiniest Radio Receiver Nathan - Mutter Museum, Philadelphia Vincent - How Rogue One is Connected to the Mac
Listener PickSam - Cell Lab: Evolution Sandbox Hannelore - Congressional Dish Johnye - The Fungi in Your Future Brendan - Zimmer on Longform podcast
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.
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Weekly Science PicksAlan - Superbugs game Dickson - Dinosaur tail trapped in amber Rich - Earth's Rotation is Slowing (original article)Kathy - Lithium Ion batteries (one and two) Vincent - Truth and Lies in the Age of Trump (virology blog) and self driving Uber car
Listener PickSteve - New York City Street Tree Map Justin - Transmissible vaccines?
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.
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Weekly Science PicksAlan - Lab Wars Dickson - Star in a Jar Fusion Reactor Rich -You're a Bee. This is What it Feels Like.Kathy - List of Potential Predatory Journals Vincent - CRISPR Patent Trial Begins
Listener PickDrake - Spinzall Katreya - Periodic Videos Pritesh - Smallpox in mummy
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.
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Weekly Science PicksAlan - Human population through time Dickson - Every Orbit Cassini Has Taken Rich - OK GO: Walk Her WalkKathy - Medieval Bestiary Online Vincent - Can You Out-Science an Eighth Grader? and Stitchen Pox
Listener PickHannah - Bioart and Bacteria
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Host: Vincent Racaniello
Guest: Gary Nabel
Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines.
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Links for this episodeSend your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero.
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Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
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Weekly Science PicksAlan - VP8SGI Dickson - New leaf-shaped spider discovered Rich - Dance of Earth and Venus About the SunKathy - Cultivar Series, Mutatoes, Uli Westphal site Vincent - Kung Fu Mantis vs Jumping Spider
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).
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Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05
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Weekly Science PicksAlan - Cubes in Space Dickson - The Architecture of Eden by H. Pearlman and A. Whalley Rich - Studying the building blocks of life in stereo (original paper)Kathy - Ancient bottom wipes yield evidence of diseases (original paper) Vincent - Iguana vs snakes
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jeremy Luban, Aaron Lin, and Ted Diehl
Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.
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Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35
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Weekly Science PicksJeremy – Real time tracking of Ebola virus evolutionTed - The Brain Scoop Aaron - Kate Rubins sequencing DNA on ISS (video) Alan – A Sand County Almanac by Aldo Leopold Rich – Vendee GlobeKathy – Axios Vincent – Vendors from above by Loes Heerinck
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Host: Vincent Racaniello
Guest: Michael Diamond
Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
Register for the 2017 ASM Scientific Writing and Publishing Online Course.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex
Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry
From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Mark Fuccio
The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Weekly Science PicksMark - EFN Enterprise Futures Network and Mission Log Podcast Alan - 2016 Wildlife Comedy Photography Rich - ZuTA, portable robotic printerKathy - How LEGO help blind people see Vincent - Airplane photos of Mike Kelley
Listener PickHannah - Frozen Flow Glass (Instagram)
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.
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Weekly Science PicksAlan - Braincraft Rich - Now is the Greatest Time to Be AliveKathy - CRISPR/Cas9 by A Capella Science Vincent - Microbes After Hours: The Necromicrobiome
Listener PickJolene - Chalk Talk Science by Dennis Mangan
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Guests: Sharon Isern and Scott Michael
Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Weekly Science PicksSharon - Zika virus comics and cartoons and Florida weekly arbovirus reportsScott - Real-time tracking of Zika virus evolution Alan - Evolution of antibiotic resistance on a mega plate Rich - WindytvKathy - Zika virus map and timeline Vincent - Ohsumi Nobel advanced information and HR 5325 funding breakdown
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Guest: Jeremy Luban
Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 28:50
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Weekly Science PicksAlan - Migration in MotionDickson - Beautiful Chemistry Rich - XKCD Timeline of Earth Temperature Kathy - Vaccine Heroes from Vaccine Education CenterJeremy - CIDRAP posters and Demon in the Freezer Vincent - People Peas and Pathogens
Listener PicksMatlock - Science isn't broken
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Hosts: Vincent Racaniello and Alan Dove
Guest: David Quammen
Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.
Watch this episode at YouTube
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Host: Vincent Racaniello
Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis
In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.
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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Host: Vincent Racaniello
Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque
In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.
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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Weekly Science PicksAlan - Infective PerspectiveDickson - The Living RiverRich - Freddy Mercury around the Sun Kathy - A Day in PompeiiVincent - Spraying Pesticides
Listener PicksRicardo - Why the metric system mattersEric - The Giving Plague by David Brin
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55
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Weekly Science PicksAlan - The VizziesDickson - NASA Spinoff Kathy - Maps.meVincent - Zika: The Emerging Epidemic by Donald McNeil
Listener PicksTarwin - Darwin's Radio by Greg Bear (paper or Kindle)Bodham - The start of scientific publishing, 1665
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Weekly Science PicksAlan - Sally Le PageDickson - Comfortably Numb by Jamie Dupuis Rich - Learned HelplessnessVincent - Virus by Marilyn Roossinck
Listener PicksOneTime - The Stranglers - Old CodgerSteve - A Poem About Pronunciation
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Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio.
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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.
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Weekly Science PicksAlan - To Scale: The Solar SystemRich - Route 66 Goes SolarVincent - Race for a Zika Vaccine by Siddhartha Mukherjee
Listener PicksBohdan - Penn and Teller on VaccinationsBill - Connections, Episode 1
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science PicksAlan - Solar storm that launched US space weather scienceRich - Data storage on DNA Dickson - Perseid meteor show liveVincent - In the Company of Microbes by Elio Schaechter
Listener PicksNeva - I Contain Multitudes by Ed YongAmanda - American Gut
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science PicksAlan - The DoubleclicksKathy - WHO ZIKV app and ZIKV Giant Microbe Dickson - Photographer Rosamond PurcellVincent - Spillover: Zika, Ebola, and Beyond
Listener PicksRicardo - Portugal Four Days on Renewable EnergyFatma - DeNovo: Predicting virus-host protein interactionsStephen - How mosquitoes use six needles to suck your blood
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Harold Varmus
The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.
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This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org
Weekly Science PicksAlan - A year on EarthRich - TWiV #1: West Nile Virus Dickson - Chasing storms, chasing beautyKathy - Bioartography and FASEB image and video competitionVincent - The Art and Politics of Science by Harold Varmus (free download)
Listener PicksTrudy - Scientific Studies on Last Week Tonight with John Oliver
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.
Links for this episodeThis episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Become a patron of TWiV.
Weekly Science PicksAlan - CDC postmortem on Ebolavirus outbreakRich - Refutations to anti-vaccine memes (Twitter, Facebook) Dickson - History of urbanizationVincent - How to cut subject from background in Photoshop
Listener PicksMarion - Skeptics Guide to the Universe podcastJennie - Leatherback turtles in Costa Rica
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Sandy Weller
Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.
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Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: David Tuller
Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.
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Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Peter Palese
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.
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Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Stephen J. Russell
From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.
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Weekly Science PicksKathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companionVincent - The Gene by Siddhartha Mukherjee
Listener PicksDylan - Microsculpture by Levon Biss (website)
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Hosts: Vincent Racaniello and Alan Dove
Guest: Erica Ollmann Saphire
Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.
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Weekly Science PicksAlan - Slime LapseVincent - Virus Watch
Listener PicksPatricia - NECSS, People Behind the Science, The Life Scientific Peter - Iron Lung on eBay
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.
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Also brought to you by ASV 2016
Weekly Science PicksAlan - All About That SpaceRich - The Expanse by James S.A. Corey (SyFy) Kathy - Five Pivotal Paragraphs in a PaperVincent - Agar Art Contest Winners
Listener PicksTed - Marshall Niremberg charts
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice
Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.
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Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guests: David Pride and Forest Rohwer
If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.
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Weekly Science PicksAlan - Vax Pack HeroRich - Helicopter autorotation Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa
Listener PicksMatt - Experiment.com
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Ethan Jackson and Jonathan Carlson
Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.
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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science PicksDickson - Germany nearly reached 100% renewable power Alan - Vertical City documentary and Lumino City gameRich - Errol Morris: ‘Demon in the Freezer’ Kathy - Entropic Time YouTube by A Capella Science (watch “the making of”)Vincent - Agar Art contest finalists
Listener PicksJennie - SciFi reading (scroll down)
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Host: Vincent Racaniello
Guest: Stan Lemon
Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.
Links for this episodeThis episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.
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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science PicksDickson - EarthEnv Alan - Research funding by lottery Kathy - Eugenia Cheng Math and BakingVincent - Zika Diaries
Listener PicksStephen - Virus trading cards William - Virus trading cards Norma+Maurice - Virus trading cards Tom - Virus trading cards
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Nina Martin
Nina Martin joins the TWiV team to talk about the movie Vaxxed, her bout with dengue fever, and the latest research on Zika virus.
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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science PicksNina - Vaccines and Your Child by Paul Offit and Charlotte MoserDickson - The animals of Chernobyl Alan - Five rules of lab safety Kathy - 20 best science images of the year?Vincent - Massive undersea crab swarm
Listener PicksJP - Global map of wind Todd - Doc Martin
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ted Diehl and Welkin Johnson
Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands.
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This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016
Weekly Science Picks 1:30:20Welkin - Lab Girl by Hope Jahren (essay)Ted - Accidental brilliance in scienceRich - Perpetual motion?Kathy - R0 graphic and explanationVincent - NWS ditches all caps forecasts
Listener PicksBasel - Gimli Glider and Mars Climate OrbiterKen - Vaccination comic book
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Stuart Firestein
Stuart joins Vincent and Dickson to talk about his sequel to Ignorance, a book called Failure, which seeks to make science more appealing by revealing its faults.
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This episode is sponsored by ASM Agar Art Contest and ASV 2016
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Rich Condit
Guests: Nischay Mishra and Ian Lipkin
Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed, and new vaccines to prevent dengue virus infections, including a human challenge model.
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This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016
Weekly Science PicksRich - Dune by Frank HerbertAlan - Adult vaccination video contestDickson - Ski town greenhouseVincent - Preprint servers: Force awakens or revenge of undead?
Listener PicksKen - Golden Mole Awards for Accidental Brilliance (list, video)Jim - Linear algebra course
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guest: Esper Kallas
Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle.
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This episode is sponsored by ASM Agar Art Contest and ASV 2016
Weekly Science PicksEsper - The Chaos by Gérard Nolst Trenité and HIV pathogenesis courseAlan - Science KombatDickson - Four steps to wiping out a mosquitoVincent - Public lacks information on Zika virusKathy - Zika virus cryo-EM structure video
Listener PicksJustin - Culture-independent discovery of Archaeal virusMelinda - Zika virus open research portal and Your body battles series
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guests: Nels Elde and Edward Chuong
Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.
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This episode is sponsored by ASM Agar Art Contest and ASV 2016
Weekly Science PicksNels - Don't Get Me Started - Matt GiorgianniAlan - Sun's magnetic field (paper)Dickson - Most realistic dinosaur terrifiesVincent - Top secret!Kathy - Zika virus risk for US 50 cities (paper)Ed - Watching comb jellies poop
Listener PicksAsal - Lost paper of Gregor MendelDennis - PhysicsGirlJacob - Second (XKCD) and ACI blogger interview
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Carl Zimmer
Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more.
Links for this episodeThis episode is sponsored by ASV 2016 and ASM Agar Art Contest
Weekly Science PicksCarl - Surprising benefit of viral DNAAlan - Global ship trafficDickson - Music with 2000 marblesVincent - The whiteboard revolutionKathy - How to interpret UK and American advisorsRich - Carina Storrs, science writer
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses.
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This episode is sponsored by ASM Agar Art Contest and Microbe Magazine Podcast
Weekly Science PicksAlan - Progression of EvolutionDickson - Toddler dies of meningitisVincent - Gardasil ideology, not scienceKathy - The Noun ProjectRich - Physics Girl
Listener PickMark - MyRadar app (iOS, Android)
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Scott Tibbetts
Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature.
Links for this episodeThis episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25
Weekly Science Picks 1:42:45Alan - Okeanos ExplorerDickson - Rome RebornVincent - Twitter Missing ManualScott - Best Science Images of 2015Kathy - Space Travel PostersRich - GoISSWatch
Listener PickPeter - Antibiotics and the Problem of the Broken Market
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guests: Greg Smith and Mark Fuccio
Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus.
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This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast
Weekly Science PicksAlan - Science byline counting projectDickson - Bill Nye on climate changeVincent - Zdziarski's blog of things (Apple's motion to vacate)Greg - Atlas, the next generationKathy - Sources of Chaco woodMark - How Dogs Love Us by Gregory Berns
Listener PickBohdan - The real reason for brains
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.
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This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast
Weekly Science PicksAlan - CDC vaccine quizDickson - A telescope so powerfulVincent - Virology Lectures 2016 (virology blog, iTunes U)Rich - Ion propulsion (Wiki)Kathy - Spurious Correlations
Listener PickJohnye - Magellan telescope and van Egmond photograpy at Kids Should See This
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jeremy Luban
The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue.
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This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016
Weekly Science PicksAlan - PhD Comics on gravitational wavesDickson - 25 years of HubbleVincent - Amazon AWS TOS and Confirming EinsteinRich - Mosquito mass productionKathy - TileAppJeremy - IL17A and autism and The Perfect Theory by Pedro Ferreira
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban
The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.
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This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar
Weekly Science Picks 1:50:45Alan - Jetstream Online School for WeatherVincent - New virus watercolors from Michele Banks (one, two)Rich - The Mad Virologist (Facebook, blog)Kathy - Orcas in AntarcticaJeremy - Pardis Sabeti on TEDHelen - Science ValentinesCarolyn - Three letter word missing from Zika warnings
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma.
Links for this episode
This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar
Weekly Science PicksAlan - Indoor skydivingVincent - Cancer Virus by Crawford, Johannessen, and RickinsonRich - WitKathy - The Only Woman in the Room by Eileen PollackDickson - Show everyone your clinical data
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Julius S. Youngner
Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.
Links for this episode
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.
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This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense
Weekly Science PicksAlan - Go viralVincent - 3D virus popsicles (3ders, dangerous popsicles)Rich - Galileo thermometerKathy - Thing Explainer by Randall Munroe
Listener PicksChristiane - Using PowerPoint to shine
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.
Links for this episodeThis episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense
Weekly Science PicksAlan - Skyfaring by Mark VanhoenackerVincent - Your Cells. Their Research. Your permission?Rich - NASA UV photos of the sunKathy - Aurora bike lightsDickson - Unfilled vials
Listener PicksKevin - John Oliver on nutritional supplementsJim - Tour of Australian synchrotron
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The TWiVomics review ten captivating virology stories from 2015.
Ten virology stories from 2015This episode is sponsored by ASM Microbe and ASM Biodefense
Weekly Science PicksAlan - Scientifics onlineVincent - Giant squid in Tokyo HarborKathy - A Year of Sky
Listener PicksDaniel - Paper LifeStephen - How to deal with science denialistsVenkat - Kabisa
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
A swarm of virologists discusses testing of a MERS coronavirus vaccine for camels, and how a neuronal stress pathway reactivates herpes simplex virus.
Links for this episodeThis episode is sponsored by Clinical Virology Symposium
Weekly Science PicksAlan - SpaceX Falcon 9 landingVincent - Scientists: Engage the public! and Lego contest winnersKathy - Google Ngram viewer
Listener PicksDennis - Americapox: The missing plagueMark - WeatherSpark and Quasispecies theory
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
A plaque of virologists explores the biology of Zika virus and recent outbreaks, and the contribution of a filamentous bacteriophage to the development of biofilms.
Links for this episode
This episode is sponsored by Clinical Virology Symposium and ASM Microbe
Weekly Science PicksAlan - Twelve days of norovirusVincent - This Week in EvolutionRich - In the Kingdom of Ice by Hampton SidesKathy - Kajanjian lecture on Frederick Novy and Milestones ceremony at UM
Listener PicksPeter - What if anti-vax, anti-science movement won?Stephen - Scandalous origin of vaccinesPritesh - Absurd way of doing business
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne and Coyne Drummond
Two Coynes join the TWiV overlords to explain their three-dimensional culture model of polarized intestinal cells for studying enterovirus infection.
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This episode is sponsored by ASM Microbe
Weekly Science PicksKathy - Tardigrade genome sequence (video)Alan - Antibiotic action nonprofit groupVincent - Ex Machina and genome editing moratoriumRich - Launch photography by Ben CooperKathy - HIV life cycle in video (paper)Dickson - 2015 Nobel Lectures Physiology or MedicineCarolyn - Metapneumovirus entry
Listener PicksTom - Global host-pathogen databaseTrudy - Madame Curie by Eve Curie
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guests: Carla Giles, Zoe Dyson, Brianna McLean, and Caitlin O'Brien
In Melbourne, Australia, Vincent speaks with four PhD students about their research projects and what it's like to get a doctorate down under.
Video of this episode: view at YouTube
This episode is sponsored by ASM Microbe and ASM Biodefense.
Send your virology questions and comments to [email protected]
TWiV is a MicrobeTV Production
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
Links for this episodeThis episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)
Weekly Science Picks 1:36:30Kathy - Tardigrade genome sequence (video)Alan - XKCD on Gates polio eradication siteVincent - Lifting the Impenetrable Veil by Charles Calisher
Listener PicksJudi - Jennifer Doudna's Ted TalkRamon - Map of the Sky
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric and Vineet Menachery
Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.
Links for this episode
This episode is sponsored by Mt. Sinai Department of Microbiology (2:10), ASM Education (33:25), and the 32nd Clinical Virology Symposium (1:51:30)
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:53:00Kathy - California Dept of Public HealthRich - Leafy greens on space stationVincent - Mechanical keyboards and TWiV on Perfect your podcast
Listener PicksJesse - Networking for Nerds by Alaina G. LevineRussell - Worldmapper
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate.
Links for this episode
This episode is sponsored by Mt. Sinai Department of Microbiology, ASM Education, and ASM Biodefense and Emerging Diseases Conference
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:29:00Kathy - Insect gearsAlan - Bye, Bye, EbolaRich - Hedy LamarrVincent - Should we resurrect extinct species?
Listener PicksJennie - Bye, Bye, EbolaPeter - Epidemics on edX
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
With their usual verve, the virus virtuosos illuminate a new method to identify all the viral nucleic acids in a sample, and regulation of viral gene expression by codon usage.
Links for this episodeThis episode is sponsored by ASM Education: ASM MOOC 5:45
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:39:20Kathy - Adam Savage, Andy Weir and Chris Hadfield talk about The MartianAlan - Project Apollo photo archive - and videoRich - Watch A Bowling Ball And Feather Falling In A VacuumDickson - California droughtVincent - Does AAAS care about Ebola anymore?
Listener PicksAnonymous - Lives saved by vaccinationPaul - Science articles: A guideJudi - How a virus invades your body
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVsters discuss Frederick Novy's return from retirement to recover a lost rat virus, and evidence for persistence of Ebolavirus in semen.
Links for this episode
This episode is sponsored by ASM Education: ASM MOOC 3:50
Weekly Science Picks 1:27:05Alan - StickyRich - Arthur C. Clarke predicts the Internet (so did Vannevar Bush)Dickson - Nikon Small World Photomicrography winnersVincent - Pat Schloss on microbiome initiative
Listener PicksAwkward Skeptic - 16 year old wins Google prize for detecting Ebolavirus
Timestamps by Jennifer. Thanks!
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Michael Imperiale, Adam Lauring, and Akira Ohno
Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.
Links for this episode
Kathy - Ada Lovelace and Charles Babbage Lego #1 and #2 and Ada Lovelace DayVincent - MiSciWriters
Listener PicksJunio - XKCD marks the spotKari - Spoonflower
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Blossom Damania
Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host.
Links for this episode
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Ileana Cristea
Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.
Links for this episode
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens Kuhn
Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate.
Links for this episode
Timestamps by Jennifer. Thanks!
Weekly Science Picks 56:30, 2:07:15Alan - The Jefferson GridRich - Summer of ScienceKathy - Bill Nye dances The ClickDickson - The MartianJens - How I Killed Pluto, Life in Our Phage World, Why the Seahorse Tail is SquareVincent - Does the public trust science? (videos, summaries)
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Stephanie Neal
Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.
Links for this episode
Alan - Plates from Hooke's MicrographiaRich - The Wright Brothers by David McCulloughKathy - Spore evaporation-driven engines (video and article)Dickson - Color variations of Pluto and Lunar total eclipseStephanie - The science of moldy cheese by Carl ZimmerVincent - But Why?
Listener Pick of the WeekReed - The Bench Warmers Podcast
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy.
Links for this episodeThis episode is sponsored by ASMGAP 5:00
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:42:20Alan - Vexed Muddler storeRich - Ivanpah Solar Power FacilityKathy - The real KermitDickson - Animal PortraitsVincent - Adventures of the Regatjes, Vaccines by Susan Nasif
Listener Pick of the WeekJacob - Great Wall of China keeps rabbits out
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus.
Links for this episodeThis episode is sponsored by ASMGAP
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:40:40Alan - Experience CuriosityRich - Primrose SchoolKathy - Egg drop solutionsDickson - Dragonflies by Pieter van DokkumVincent - NASA guide to air-filtering houseplants
Listener Pick of the WeekAmir - Publons (Nature article)
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.
Links for this episodeThis episode is sponsored by ASMGAP 3:10
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:27:50Alan - Miniature calendarKathy - Dr. Brainlove (prologue, v. 2.0, IndieGoGo)Dickson - The Ph.D. MovieVincent - Ghostery
Listener Pick of the WeekRamon - Children dieChris - ASMLive at ICAAC/ICC
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Michele Banks
Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art.
Links for this episode
Send your virology questions and comments to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.
Links for this episodeAlan - Genetic roulette Rich - The Huntington Kathy - Simulated vomiting machine (video) Dickson - Last Cassini Saturn flybyVincent - Decaying Still Life (YouTube)
Listener Pick of the WeekKen - Cave meterology (Times, Nature)
Send your virology questions and comments to [email protected]
Host: Vincent Racaniello
Guest: Katherine A. High
Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.
This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology.
Links for this episode
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.
Links for this episode
This episode is sponsored by ASM GAP
Weekly Science PicksAlan - Above and BeyondRich - DSCOVR (Dark moon side crossing Earth)Vincent - Stuxnet virus (Wired, YouTube)
Listener Pick of the WeekKonrad - Stated Clearly
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.
Links for this episode
This episode is sponsored by ASM GAP
Weekly Science PicksRich - Swan-Ganz catheter (Wiki, video)Vincent - Mobile DNA III
Listener Pick of the WeekKevin - Synthetic prions
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.
Links for this episodeThis episode is sponsored by ASM GAP and ICAAC/ICC
Time stamps by Jennifer. Thanks!
Weekly Science Picks 1:17:05Alan - National Immunization Awareness Month (Twitter campaign)Rich - Rosie Revere, Engineer by Andrea BeatyVincent - iPhone owns podcasts (9to5Mac)
Listener Pick of the WeekSandra - World Zoonoses Day graphicPeter - Mammal-carnivorous plant mutualism (bat and shrew)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Joan Steitz
This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.
Links for this episodeKathy - Charity HallRich - Ribosome binding sites of phage R17 mRNAVincent - Pluto flyby
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy.
Links for this episodeThis episode is sponsored by ASM GAP - turn your science into a company
Weekly Science PicksDickson - Algal DMS releasing enzymeAlan - Science of beer agingKathy - The Art of Science winnersVincent - The future of Lego plastics
Listener Pick of the WeekEric - Economics in One Lesson by Henry HazzilitStephen - The Martian by Andy Weir (audiobook)
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Ruth Jarrett, Glen Nemerow, and Esther Schnettler
At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science Picks 1:41:45Dickson - Global rainfall and snowfall map and A Week in the Life of RainAlan - Automated patch clampKathy - More Women in Science mini LegosRich - The Martian trailerVincent - It's a bug's life
Listener Pick of the WeekMay - p53 by Sue Armstrong
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science PicksDickson - Incredible photosAlan - Alone in a room full of science writersKathy - Calico cats and Siamese catsRich - Missing link in evolutionVincent - Podcasts saving NPR and Podcasting blossoms
Listener Pick of the WeekJenny - What Bill Gates is afraid ofNeva - The Kardashian Index
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Adam Kucharski, Gillian Slack, and Emma Thomson
Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa.
Links for this episodeTimestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.
Links for this episodeDickson - Singapore Flower Dome and Cloud ForestAlan - Rescuing biomedical researchKathy - The value of basic researchRich - Virology 60th Anniversary IssueVincent - Careers in virology: Science writing and journalism
Listener Pick of the WeekPritesh - How T cells kill cancer cellsRamon - The power of herd immunity
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination.
Links for this episodeAlan - Fooling millions into thinking chocolate helps weight lossKathy - Approaching PlutoVincent - ASM Agar art contest
Listener Pick of the WeekDaniel - FB pages you need to stop sharing from (one and two)Ken - Bird box science (canceled)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Kathy Spindler
Guest: Laura Newcomb
Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection.
Links for this episodeLaura - NP siRNA inhibits different influenza viruses (Antiviral Res)Kathy - Time-lapse miningVincent - Does the public trust science?
Listener Pick of the WeekPaul - Degree-Off XKCDPeter - Ebola containment, Hans Rosling, eLife podcast, Naked Scientists
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Michael Metzger and Steve Goff
Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome.
Links for this episodeTimestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids.
This episode is sponsored by @ASM Conferences and ASM Microbe
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science PicksAlan - Winogradsky time-lapseRich - Missing link in evolution of complex cellsKathy - GrantomeDickson - National Geographic Landscape Photo of the DayVincent - PyMol and Chimera
Listener Pick of the WeekMauricio - Vax!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.
This episode is sponsored by ASM Microbe and ICAAC/ICC
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science PicksAlan - PinboardRich - Academic medicine investment in medical researchKathy - Tissue paper stop motion animationDickson - Do peer review panels select best science proposals?Vincent - MMR and autism: Still no association
Listener Pick of the WeekRamon - Autism by MMR vaccine statusMehul - Ebolavirus disease courseJustin - Molecular Biology of Bacterial Viruses by Gunther S. Stent
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science Picks 1:17:05Alan - NIH RFI: How do we fix this mess?Rich - Editing embryos (PopSci, Prot Cell)Kathy - Creative class presentations (one, two, three, four)Dickson - The most tornadoesVincent - Apollo 13, 45 years later (Ars, IEEE, Farewell)
Listener Pick of the WeekJohnye - Rudolf and Leopold Blaschka
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers
Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Seth Bordenstein, James Crowe, and Mark Denison
Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses.
Links for this episode
Timestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to [email protected]
The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science Picks 1:53:50Alan - OU0POLIO ham radio special event station (on air reports)Rich - Crane building itself (YouTube)Kathy - Vaccine heroes LEGO projectDickson - Life at the limitsVincent - Emperor of all Maladies film and Conference gender balance
Listener Pick of the WeekJake - Designing useful microbes
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science PicksAlan - X-Flare 2.1 capturedRich - Volvo ocean race drops research buoys (YouTube)Kathy - Nature double-blind peer reviewDickson - Largest cave in the worldVincent - New program for early-career scientists
Listener Pick of the WeekMichael - Space Engine and Kerbal Space ProgramVarun CN - Incognito by David Eagleman
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.
Links for this episodeTimestamps by Jennifer. Thank you!
Weekly Science Picks 1:35:10Alan - NASA Solar Dynamics Observatory videoRich - Mutagenic chain reaction (Video: Genome editing with CRISPR)Kathy - Science Ambassadors ProgramDickson - Street ArtVincent - End Polio Now
Listener Pick of the WeekRoss - Three PhD Comics on Nature vs Science (one, two, three)Ricardo - Demographic Party Trick
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Links for this episode
Alan - Positively Negative (PLoS One)Rich - ISS assembly (YouTube)Kathy - Ancient treesDickson - Carolyn PorcoVincent - Tony Fauci on Ebola outbreak (YouTube)
Listener Pick of the WeekDavid - Shot by ShotJudi - The Power of Herd Immunity
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.
Links for this episodeAlan - California bill to eliminate personal vaccine exemptionsRich - Kepler observatory (Kepler-186f)Kathy - USGS disease mapDickson - Philosphy of Microbiology by Maureen O'MalleyVincent - Nautilus
Listener Pick of the WeekKen - Life in our phage world (online, book party); All about that baseNeal - Gilles van Cutsem at CROIRicardo - Flow hive
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.
Links for this episodeAlan - Toms River by Dan FaginRich - Spin by Robert CharlesVincent - FCC votes for net neutrality (ArsTechnica)
Listener Pick of the WeekNeal - Why doesn't everyone get the flu vaccine?Fernando - Zombie Jonas Salk hunts idiotsNeva - Physicists in biology
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Rollie Clem and Lorena Passarelli
Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Lee Feinman
Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.
Links for this episodeLee - Furthering America's Research and Upgoer five and sixAlan - Best snow shovelRich - Ripple tankKathy - FractalsDickson - World Press Photo Contest 2015Vincent - What to do about antivax politicians and physicians
Listener Pick of the WeekPatricia - Future of Bioscience Graduate & Postdoc trainingPaul - This is my son Griffin, and he may have measles
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis.
Links for this episodeAlan - SitesuckerRich - Snake picked wrong dinnerDickson - Sapporo Snow FestivalVincent - Mapping NYC subway DNA
Listener Pick of the WeekGretchen - Scientific way to cut a cakeLeslie - Principles of Virology, Second Edition
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.
Links for this episodeAlan - Boom by Tony HorowitzKathy - Octopus supermomDickson - MacrophotographyVincent - Virology lectures 2015 (virology blog and YouTube)
Listener Pick of the WeekPaul - Illsville: Fight the DiseaseRamon - Vaccinate! Do it for the testiclesSandra - Who can you trust?
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Paul Duprex
Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.
Links for this episodeAlan - In a Sunburned Country by Bill BrysonPaul - Saving the lives of our dogs (blog post)Kathy - New all-female Lego setDickson - Female storm-chaserVincent - Despommier Photo Art
Listener Pick of the WeekJacob - Exaggeration in news and press releases (BMJ)Peter - Quartet game (photos: one, two, three, four, five)
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: John Coffin
Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.
Links for this episode
Alan - The Toaster Project by Thomas ThwaitesRich - SpaceX reusable rocket (SpaceX)Kathy - Antarctica: A Year on IceDickson - NHL Mumps outbreak and Hubble Andromeda imageVincent - We the Microbiologist
Listener Pick of the WeekNeva - Mosquito earringsBasel - Flu vaccine selection meeting
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.
Ten virology stories of 2014
Alan - Mystery photos from CERNRich - Adam E. Cohen: Bringing bioelectricity to lightKathy - Wired's top microbe stories of 2014Dickson - Mouse jokeVincent - The Science of Epidemics (Time Inc Special)
Listener Pick of the WeekNeva - Sir BacteriophageSagi - An unboring polio documentary
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa
On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.
Video of this episode: view at YouTube
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.
Links for this episode
Alan - It came from the pondRich - WanderersKathy - The Sense of Style by Steven PinkerVincent - Life in Our Phage World
Listener Pick of the WeekFernando - Reality based?
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.
Links for this episodeAlan - ReelLife Science 2014 WinnersRich - The Martian by Andy WeirKathy - Dance Your Ph.D. WinnerVincent - Time Person of the Year 2014 - The Ebola Fighters
Listener Pick of the WeekRicardo - MiniPCREli - Let's outsmart Ebola together AND The Ebola virus explained
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian
Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.
Links for this episodeAlan - RetrocomputingRich - Where is Rosetta?Vincent - Antares rocket explosion
Listener Pick of the WeekSimon - Relatively PrimeMark - Giant Microbes
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - How Ebola airlifts workKathy - Fred Murphy's Foundations of VirologyRich - Pendulum waveDickson - Young DipteristsVincent - Microbes After Hours: Ebola and TWiV iPhone 6 case
Listener Pick of the WeekAlane - Health MapTodd - Formaldehyde in vaccines
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.
Links for this episode
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Glenn Rall
Guest: Ann Skalka
Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.
Links for this episode
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - CDC Influenza activity weekly mapsKathy - Going Deep with David ReesRich - Virology Special Issue: Giant VirusesDickson - Nikon Small World WinnersVincent - TWiM #90 and Republicans are not scientists
Listener Pick of the WeekPaul - Tricks and Tools of Great ScientistsYegor - Hardcore HistoryAmanda - Vaccine ingredients; Anti-vaxers damage; Minds of anti-vaxers
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: Tom Solomon
Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor.
Links for this episode
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Guest: Tara C. Smith
Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - Fall foliage mapKathy - Interviews with Peter Piot (one, two) and autobiographyVincent - The Ebola connection
Listener Pick of the WeekBrooke - N.B. Designs on EtsyVictor - SMBC
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - The Sixth Extinction by Elizabeth KolbertKathy - Seeing the InvisibleVincent - 2014 Scientific American Science in Action Award winner
Listener Pick of the WeekMauricio - Investigating a mystery diseaseHeather - Diversity Journal ClubJohnye - Flu Attack!
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - Under the knife, episode 1Kathy - UCSC Ebola genome portalVincent - Annual Review of Virology, volume 1
Listener Pick of the WeekAlan - H5N1Peter - Vomiting LarryDara - I just can't wait for my vaccine!
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Jeff Shaman
The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - Fabre's Book of InsectsKathy - Origami microscope for 50 centsDickson - Landsat 8Vincent - Some advice from Jeff Bezos
Listener Pick of the WeekJustin - Brazil releases 'good' mosquitoes to fight dengue fever
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episodeAlan - PhotogrammarKathy - Refrigerate your tomatoes?Dickson - Robot swarmVincent - The Beginner's guide to winning the Nobel Prize by Peter Doherty
Listener Pick of the WeekDee - Publish scientific research faster on TWiSTBasel - Lego microscope (vote for it)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68.
Links for this episodeAlan - Index to creationist claimsRich - Wild KrattsKathy - Worn awayDickson - Iceland volcano eruptionVincent - Immune Quest
Listener Pick of the WeekKay - Landes Bioscience open access books
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Carla Saleh and Curtis Suttle
At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science.
Links for this episodeAlan - The Internet's Original SinDickson - PlacidcoyoteRich - Scientific Method, Grail StyleKathy - Viruses Throughout Life and TimeVincent - ALS Ice Bucket Challenge
Listener Pick of the WeekJim - iBiologyVictoria - Images of ScienceMehul/Walt - Calling the Shots
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Marshall Bloom, Sonja Best, and Byron Caughey
Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of disseminated multiple myeloma with oncolytic measles virus.
Links for this episodeAlan - WTF, Evolution?! by Mara GrunbaumRich - Cold Spring Harbor Oral History CollectionKathy - Inside insidesVincent - Going Viral (Rocky Mountain Ballet Theatre)
Listener Pick of the WeekKim - Nobel Prize PodcastsJohnye - The Planet is FineJennie - Counter-Zombie Dominance Plan (pdf)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline.
Links for this episodeAlan - Historical perspective on Ebola (Tara C Smith)Rich - Tell the negative committee to shut up (Fanuel Muindi)Kathy - Art of Night (Vimeo)Vincent - Is Ebola virus going to kill me? (John Skylar)
Listener Pick of the WeekPeter - Dr. Michael Saag interview by Dr. Virginia CampbellDavid - PI Predictor (app, article, publication)
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: Linfa Wang
Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.
Links for this episode
Alan - Nicky Bay macrophotography (Flickr)Rich - FASEB Third annual BioArt competitionVincent - Up Close podcast (vrr episode)Dickson - Science fun (YouTube)
Listener Pick of the WeekMark Martin - Average bacteriophageKonrad - Scholarpedia
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.
Links for this episodeAlan - OptivisorRich - Noller lab ribosome moviesVincent - Creepy dreadful wonderful parasitesDickson - National Center for Science Education
Listener Pick of the WeekMark - The Machinery of Life by David GoodsellBasel - iBioEducation
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Melissa Churchill, Alex Khromykh, Gilda Tachedjian, and Paul Young
Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller
Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Clodagh O'Shea and Ron Fouchier
Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.
Links for this episodeRich - No sexual transmission of HCV (Am J Gastro)Vincent - Made with code (blog post)Kathy - Beautiful math images (and 50 Visions of Mathematics)
Listener Pick of the WeekJon - Advances in Life Sciences winners (YouTube)Dave - Adam Ruben
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Janet Butel and Rick Lloyd
Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.
Links for this episodeAlan - The Science of Good Cooking Vincent - The Shooter Report (pdf)Kathy - Daily overviewDickson - Girl rising
Listener Pick of the WeekJohnye - Ri channelRicardo - Open spin microscope (Nikon gallery, plans)Chris - The microbiome game
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.
Links for this episodeRich - LuvalampsAlan - ExperimentVincent - American Society for Virology on FacebookKathy - LEGO female scientistsDickson - The Oldest Living Things in the World by Rachel Sussman
Listener Pick of the WeekBasel - A Treatise on the small-pox and measles by Abu-Bakr Al-Razi
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Matt Frieman
Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.
Links for this episodeMatt - Forgive me, scientistsAlan - Do not linkVincent - bioRxivKathy - Snail photographsDickson - Solar roadways
Listener Pick of the WeekDaniel - Benz Biome concept car
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Alan Dove
Guests: Julie Pfeiffer and Paul Duprex
Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.
Links for this episodeVincent - ASM Live 2014Alan - I will not follow the herdPaul - Invisible ThreatJulie - The importance of stupidity in biological research
Listener Pick of the WeekNeil - WEHI movies and VIZBI
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: XJ Meng and Sarah McDonald
Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed.
Links for this episodeRich - EPCOTVincent - Medical BiotechnologyKathy - Alan Alda interview and Flame Challenge winnerDickson - NASA live from space
Listener Pick of the WeekNicola - 50 cent microscope (be a beta tester)Jon - Camtasia Studio
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens H. Kuhn
Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea.
Links for this episodeAlan - AMNH digital special collectionsVincent - Viral entry into host cells (Stefan Pöhlmann PhD, Graham Simmons PhD, eds)Kathy - Papilloma song lyrics (pdf)Jens - The Logic of Chance by Eugene V. Koonin
Listener Pick of the WeekJoe - Poor showing of 2012 influenza vaccine (Nature)Phil - Emerging disease or emerging diagnosis? (YouTube)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws.
Links for this episodeAlan - Northampton AirportVincent - Particle FeverKathy - Turn iPhone into microscopeRich - My favorite science gifs
Listener Pick of the WeekNathan - The Ascent of Man (YouTube)
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: Peter L. Salk
Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more.
Links for this episodeAlan - Heartbleed explanationVincent - Agriculture science today podcastKathy - Quizlet flashcards (online and iTunes)Rich - Why nothing is truly alive
Listener Pick of the WeekLance - Myles Power (YouTube and Facebook)Raihan - Cheap DIY microscopeGerald - DaVinci PressNeal - I'm a virus
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body.
Links for this episodeAlan - HeathkitVincent - How to think about autism risk and Autism prevalenceKathy - Distortions
Listener Pick of the WeekJoseph - The real process of scienceMarion - ZometoolKevin - Audioimmunity and Emmunity
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1.
Links for this episodeAlan - Digital scale model of solar systemDickson - Font of knowledgeVincent - Measles outbreaks trends, and NYC measles (one, two)Kathy - Winner, funding basic science to revolutionize medicine
Listener Pick of the WeekStephen & Jon - Watty's Wall StuffJohyne - Macro views of snowflakesRicardo & Stephen - Vaccine exemptionsBill - Books by John JanovyMarshall - Animation of DNA replicationSteve - Debunking influenza vaccine myths
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Glenn Rall, Ann Skalka, and Vincent Racaniello
Glenn and Ann meet up with Vincent to talk about his career in science and science communication.
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Susan Baker and Thomas Gallagher
Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses.
Links for this episodeVincent - First demonstration of Macintosh, 1984
Listener Pick of the WeekLance - The Signal and the Noise by Nate Silver
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guest: Eugene Koonin
Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces.
Links for this episodeAlan - The science of science communicationRich - Command and Control by Eric SchlosserDickson - Top 10 plant virusesVincent - Is the Nobel Prize good for science?Kathy - Time to rethink graduate and postdoc education (YouTube)
Listener Pick of the WeekJon - Lessons from a Kansas graveyardMike - Cross a fashion designer with a microbiologist
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: W. Ian Lipkin and Thomas Briese
Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection.
Links for this episodeRich - Think like a scientist (one, two); Science controversiesDickson - Visualization challenge 2013Vincent - Orphan BlackKathy - Alberta worm invasion project
Listener Pick of the WeekTimothy - How do vaccines cause autism?Anne - Luke Jerram's glass virusesJim - NLM Communications Engineering BranchSteve - Synapse by synapseJacob - Tiny technology creates a buzz
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene.
Links for this episodeAlan - Statistical error (Nature)Rich - 12 oldest animal speciesDickson - When liquids collideVincent - HIV denial and just asking questionsKathy - Sun's canyon of fire
Listener Pick of the WeekSandra - Women physicists keep female students psychedJudi - HHMI's BiointeractiveJacob - Influenza virus HA
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Ashlee Bennett
The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates.
Links for this episodeAlan - Nagasaki bombing (YouTube)Rich - GoPro Red Bull Stratos (YouTube)Dickson - Solar orbsVincent - Socrative
Listener Pick of the WeekBasel - Pathology course onlineRussell - Sochi 2014: Encyclopedia of spendingYegor - Visual Science
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guests: Dennis Hruby and Yoshihiro Kawaoka
Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC.
Links for this episodeVincent - Quanta MagazineRich - Colour is in the eye of the beholder
Listener Pick of the WeekKehau - Beautiful but deadly viruses
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16.
Links for this episodeKathy - Female conveners and speakersAlan - SandgrainsRich - 2013 Lamborghini AventadorVincent - Happy Birthday Mac and 128K Mac teardownDickson - Farmdominion
Listener Pick of the WeekPeter - The Microscope and The Next Global KillerRichard - Glass viruses
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett
Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity.
Links for this episodeKathy - Jean-Luc Doumont (slides, communicating science, website, Scitable)Alan - Wireless thermometerVincent - LORiOLA viral necklaces
Listener Pick of the WeekJessica - Knit icosahedronRobert - Practical computing for biologists by Haddock and DunnStephen - Fourteen years of US weather (YouTube)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid.
Links for this episodeKathy - Amazing mapsAlan - Florida to NJ in 156 seconds (YouTube)Rich - Whiteout over Great Lakes from SpaceVincent - LORiOLA viral necklaces
Listener Pick of the WeekCarol - Knit picornavirusRobert - RNA: Life's Indispensible Molecule by James Darnell,and Biochemical Pathways by Michal and Schomburg
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis.
Links for this episodeKathy - 17 mundane things, mind blowing viewsAlan - SnowovelVincent - Public's views on human evolution
Listener Pick of the WeekEmily - Dengue pillow
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013.
Links for this episodeKathy - Women in ScienceAlan - ContagiumRich - RC helicopter (demo)Vincent - The athletic power of quadcopters
Listener Pick of the WeekLindsay - Alcohol consumption and vaccines (Vaccine)Johnye - The Singing Microbiologist
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.
Links for this episodeKathy - Sorting algorithms visualizedAlan - StratodeanRich - Art in Science by Polyxeni PotterVincent - Pixel Genes
Listener Pick of the WeekJudi - Olympus BioScapes Winner
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Ben tenOever
Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice.
Links for this episodeKathy - The Brain Scoop, esp. Where My Ladies AtAlan - Say 'hi' to a spaceship (YouTube)Rich - Garmin BlueChart Mobile and Active CaptainVincent - Journal boycott (one, two)Dickson - Futurescape TV show
Listener Pick of the WeekLuis - Spillover by David QuammenKen - Gravity
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: Ann Palmenberg
Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and James Van Etten
Guests: Chantal Abergel and Jean-Michel Claverie
Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Tom Friedrich, Tony Goldberg, and David O'Connor
Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guest: Jaquelin Dudley
Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus.
Links for this episodeSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman
Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.
Links for this episodeKathy - Optical illusion (YouTube)Alan - AmboceptorMatt - Reply all by Richie Frieman (audio sample)Vincent - The microbiology of beer
Listener Pick of the WeekCassie - NeatoShopPeter - Synapse evolution with Seth Grant (BSP 101)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research.
Links for this episodeDickson - Tesla Motors superchargerKathy - FASEB contest: Stand out for scienceAlan - Natural History Museum virtual tourRich - Mauna Kea heavensVincent - FAA expands use of electronics on planes
Listener Pick of the WeekPeter - Score and ignore (pdf)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals.
Links for this episode:Dickson - Wildlife Photographers of the Year 2013Kathy - John Holland's Emerging Infectious Disease lecture (YouTube)Alan - The worst part is notRich - The Universe in a Single Atom by Dalai Lama (Mind and Life Institute)Vincent - The Truth about T. Rex by Brian Switek
Listener Pick of the WeekStephen - International Institute for Species Exploration (Top 10 species choice)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guests: Robert Krug and Christopher Sullivan
Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs.
Links for this episode:Rich - Unraveling BoleroVincent - New botulinum toxin, DURC implications, and inconvenient truths
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector.
Links for this episode:Dickson - The Man Who Planted Trees by Jean GionoKathy - A boy and his atom and Moving Atoms (YouTube)Alan - It is pitch dark and Get Lamp (YouTube)Vincent - Who's afraid of peer review? (Science)
Listener Pick of the WeekMaren - Hello Maestro (episodes on YouTube)Ayesha - Why you don't f****** love scienceJon - A Capella Science (YouTube)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more.
Links for this episode:Dickson - HD slow motion montage (YouTube)Kathy - Damselflies and Eyewitness appAlan - Space weather forecast (YouTube)Rich - 1984 by George Orwell (Doublethink)Vincent - PopSci comments off and Why so few women in science?
Listener Pick of the WeekMeika - Flip action roll (YouTube)CN - Blink: The Power of Thinking without Thinking by Malcolm GladwellBernadeta - Higgs Boson wins Nobel Prize
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more.
Links for this episode:Dickson - A Sand County Almanac by Aldo LeopoldKathy - Noctilucent clouds and aurora over ScotlandAlan - Flu vaccination mapRich - There's a fly in my urinalVincent - Picornaviridae.com
Listener Pick of the WeekPeter - PDB-101Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist.
Links for this episode:Dickson - Scharf PhotoKathy - Blaschka glass models (NY Times, Cornell)Alan - Digital Public Library of AmericaRich - Dengue virus life cycle animationVincent - Creative Live
Listener Pick of the WeekJohn - Last person to get smallpox (NPR)Peter - SARS documentary (BBC)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Robert Garcea
Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses.
Links for this episode:Robert - The Panic Virus by Seth MnookinVincent - Aliens chestburster behind the scenes
Listener Pick of the WeekAdam - Virology Fact of the DayChristophe - dr Karl
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth.
Links for this episode:Alan - Extreme macrophotographyDickson - Baloney detection kitRich - Mutant silkworms spin colored silk (original article)Vincent - FlightRadar24
Listener Pick of the WeekJenn - Ebola by William CloseJenn - Eleven Blue Men by Berton RouecheNissin -Profiles in Science
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds.
Links for this episode:Dickson - Google SkyRich - Vanishing of the Bees (see also Bee Apocalypse Now)Vincent - Not Exactly Rocket Science
Listener Pick of the WeekSaira - Reproducibility Initiative
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Special guest: Ian Lipkin
Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus.
Links for this episode:Kathy - Rainbows explained (Frazz)Alan - Challenge.govVincent - 23andmeRich - Spot the station
Listener Pick of the WeekFrank - Pacifier cleaning practices and risk of allergy development (Pediatrics)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence.
Links for this episode:Kathy - GeoGuesserAlan - From one, many (YouTube)Vincent - Dave Bhella: The Wildy Award Talk (Microbeworld video)Rich - 1981 primitive internet report (YouTube)
Listener Pick of the WeekCN - How the Mind Works by Steven Pinker
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka
The authors of the popular textbook Principles of Virology discuss how the book was conceived and written.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Alan Dove
Guests: Dan Barouch and Jeff Teigler
This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines.
Links for this episode:Jeff - Science in the News; How to succeed in science (part one and part two)Alan - Nanostructure flowersVincent - Scientific culture
Listener Pick of the WeekBasel - The sequester blues
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Rebecca Dutch and Christiane Wobus
On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses.
Links for this episode:Kathy - Shuffling cardsVincent - Dave Bhella - Electron cryomicroscopyRich - Seven-year postdoc
Listener Pick of the WeekJudi - Reading for science literacy
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein.
Links for this episode:Dickson - Mantid imagesKathy - No email? (phd comics)Alan - The turbid plaqueVincent - AAM Faq: West Nile VirusRich - Science is awesome
Listener Pick of the WeekLuis - Public Health Image LibraryStephen - Hopkins closes graduate science-writing program
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933.
Links for this episode:
Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories)
Listener Pick of the WeekJoe - Grand challenges in science education (Science)Mark - Weather Underground
Send your virology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Markus Thali and Jason Botten
Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses.
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman
Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.
Links for this episode:Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories)
Listener Pick of the WeekEbrahim - Virus Hunter by CJ Peters and Mark Olshaker
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.
Links for this episode:Kathy - Vaccine-preventable outbreaksRich - To Catch a Virus by John Booss and Marilyn J. AugustVincent - This is Water by David Foster Wallace
Listener Pick of the WeekJon - Confessions of a converted lecturer by Eric MazurPeter - FameLab
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guest: Michael Emerman
Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.
Links for this episode:Molly - Facts in the case of Dr. Andrew Wakefield
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.
Links for this episode:Alan - Psychology of antivaccinationistsVincent - Virology on CourseraKathy - Meteorites through the ages
Listener Pick of the WeekBasel - Self-medication in animalsSheryl - Noadi's artFelicity - Survival of the Sickest by Sharon Moalem
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Rich Condit
Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell
Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Nels Elde and Tom Shenk
Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.
Links for this episode:Alan - Space Oddity (YouTube)Rich - Walk through giant colonVincent - Transport proteinsKathy - Vomiting Larry (YouTube)
Listener Pick of the WeekTom - US patent system is broken (DailyTech)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff
Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin
Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.
Links for this episode:Alan - World Science FestivalRich - 3 years of the sun in 3 minutesVincent - The Origin of AIDS by Jacques PepinKathy - Wringing out a wet washcloth in space (YouTube)
Listener Pick of the WeekMark - Will it blend? (iPhone app)Marianne - Enjoy your Cells
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove
Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.
Links for this episode:Alan - Nature PastCastRich - How dengue does itVincent - Squeaky Squeegee Art by Deb SklutDickson - Agritecture
Listener Pick of the WeekMike - Chemistry in its element: Elements and Compounds
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris
Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.
Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus.
Links for this episode:Kathy - NIAID YouTube videosAlan - Lego insectsRich - How to see the world in a grain of sandVincent - Vaccines, viruses, and the anti-vax movementDickson - Edinburgh Science Festival
Listener Pick of the WeekStephen - Nature iOS appMehul - Voices for vaccines
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody
Vincent and Dickson speak with Terry Dermody about his career in medicine and virology.
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more.
Links for this episode:Kathy - Case stories about CoV-EMC (one, two)Rich - The Self-Illusion by Bruce HoodVincent - Moving Targets
Listener Pick of the WeekLiam - eLIFE and RubriqSteve - Plant virus ecology (mp3)Neil - World Immunization Week
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract.
Links for this episode:Kathy - 2013 Intel Science Talent Search awardsAlan - Krebs Cycle Rap (CDC)Vincent - Jetpens (favorite one and two)D ickson - Rabies death in organ recipients (CDC)
Listener Pick of the WeekJustin - The DNA StoreJim - Massive Open Online ClassroomsChris - Feedly
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells.
Links for this episode:Kathy - Finkbeiner test and Women in ScienceAlan - New flu vaccine efficacy study (CDC)Vincent - Threading the NEIDL video
Listener Pick of the WeekSteve - Prof. Joan Steitz on viral RNAEd - Archiving history of molecular biology: Press release, video, CSHL archives and videos
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.
Links for this episode:Kathy - Graphene batteriesAlan - How do we get cures? (YouTube)Rich - Explosive breach of Condit Dam (Vimeo)Vincent - 10 things you can do to support open access (Tree of Life)
Listener Pick of the WeekMark - The real story of StuxnetJohn - D-connector virus
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler
Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.
Links for this episode:Kathy - Winners, 2012 Science & Engineering Visualization ChallengeVincent - The Operator and Dr. Oz's Problem
Listener Pick of the WeekSend your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.
Links for this episode:Kathy - Journal of Virology Image GalleryRich - Phage T7 Genetics and Physiology and slab gelsAlan - PeerJ (press release)Vincent - Virologia en Español
Listener Pick of the WeekDave - Thingiverse pathogens and proteins
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci
Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson
Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.
Links for this episode:Welkin - Viruses: Essential Agents of Life (review at STC)Alan - Infinity ImaginedVincent - Spaceship built for son
Listener Pick of the WeekAmanda - Written? Kitten!Kevin - Protein synthesis: An epic (YouTube)Daria - The Baltimore Scheme
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier
Vincent, Alan, Rich, and Dickson review influenza vaccines.
Links for this episode:Rich - Repoopulate (original article), Robogut (new clinical trial)Alan - WTF, Evolution?Dickson - The Beauty and Benefits of ScienceVincent - Supercomputing modeling of poliovirus
Listener Pick of the WeekBjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.
Links for this episode:Rich - Linus Pauling's explanation of science (YouTube)Alan - Underwater experimentsKathy - I'm a virus (YouTube)Vincent - Stem cells (Bizarro Comics)
Listener Pick of the WeekTom - The President's AnalystDanielle - Overly honest methods (HuffPost and ASBMB Today)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.
Links for this episode:Alan - I'm a Scientist - The FilmKathy - Humorous units of measurement (Wikipedia)Vincent - Open access must enable open use (Nature)
Listener Pick of the WeekTarwin - Plague Inc.
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.
Links for this episode:Alan - Parasite of the DayKathy - Tour of International Space StationVincent - Earth as Art
Listener Pick of the WeekRobin - Angell on Big PharmaMichael - Flu jokesJim - Database of Ted talks; Downloadable Ted Talks
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012.
Twelve virology stories from 2012:Rich - Our Mr. Sun (IMDB entry) (wiki)Alan - PubReader from NCBI announcement and instructionsKathy - Popular Mechanics 110 picks for the next 110 yearsVincent - 366 days: Nature's 10
Listener Pick of the WeekMatt - The flu vaccine controversy
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Stuart Firestein
Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more.
Links for this episode:Rich - OverviewAlan - Notes towards the complete works of ShakespeareKathy - Correlation vs. Causation (#1, #2, #3)Vincent - Periodically inspired
Listener Pick of the WeekMark - Life of a Nature paperRicardo - Things don't go viral
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA.
Links for this episode:Rich - Ocean Global Shark TrackerAlan - The Field Book ProjectKathy - How to manipulate an army of zombiesVincent - Science sculpture
Listener Pick of the WeekStephen - WEHI.TV
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA.
Links for this episode:Rich - Vendée GlobeDickson - Earth at nightAlan - Trophée Jules VerneKathy - Science cookiesVincent - Trilobite Glassworks
Listener Pick of the WeekKen - Spanish flu pandemic model (teacher's guide)Jim - Santa Cruz Science Communication Program (also see SHERP)
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more.
Links for this episode:
Dickson - Cassini web site and Mars reconnaissance orbiterAlan - OneZoom Tree of LifeKathy - Viral tumor suppressor structure (Cell)Vincent - Spot the Station
Listener Pick of the WeekRicardo - Once upon a time: The possible story of virusesJim - Encode, myIDP, Experiment Reproduction podcastsMark - MoMath
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Jon Yewdell
Vincent and is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus.
Links for this episode:Matt - Virus-associated pyramids (slide #11)Alan - Similarities of wave behavior (YouTube)Kathy - The glass transitionVincent - US cattle country in uproar at virus lab plans (BBC)
Listener Pick of the WeekRicardo - Blackawton bees and Science is for everyone (TED)Tony - Biophilia by Bjork
Send your virology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Kathy Spindler
Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses.
Links for this episode:Alan - Locust by Jeffery A. LockwoodDickson - Nikon Small World Contest 2012Kathy - Influenza EncyclopediaVincent - Dengue fever sweeps India (NY Times)
Listener Pick of the WeekAllison - Fred Guterl on The Daily Show
Send your virology questions and comments (email or mp3 file) to [email protected].
Hosts: Vincent Racaniello and Harmit Malik
Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict.
Links for this episode:Vincent - Candidates' answers to science questions
Listener Pick of the WeekSteve - Mural of Henrietta Lacks story (Microsoft Silverlight required)
Send your virology questions and comments (email or mp3 file) to [email protected]. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Alan - Map of the WindMatt - Dark Side of the Earth; Insensitive guide to thriving in your Ph.D.; Gary Vanerchuck (YouTube)Kathy - How much does a shadow weigh? and Slinky drop answerVincent - A Parasite's Parasites; All the cool kids are on arXiv
Listener Pick of the WeekNissin - Jungle Jim (1948)
Send your virology questions and comments (email or mp3 file) to [email protected]. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Rich Condit, and Mark Challberg
Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Rich - Mattel Hot Wheels Curiosity RoverVincent - Should H5N1 Moratorium End?
Listener Pick of the WeekClaudio - DIY lab equipment (Ars Technica) and DIY Bio
Send your virology questions and comments (email or mp3 file) to [email protected]. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, T. Jack Morris, James Van Etten, and Charles Wood
Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi's sarcoma herpesvirus.
Links for this episode:Charles - Rhabdovirus associated with hemorrhagic fever (PLoS Path)Vincent - Bacteriophage graffiti (jpg)
Listener Pick of the WeekBob - Remembering Penny PinneoJanet - Penn and Teller on vaccinations (YouTube)
Send your virology questions and comments (email or mp3 file) to [email protected]. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more.
Links for this episode:Alan - Wallace OnlineRich - World Rabies DayKathy - Yo-yos in spaceDickson - The Art in ScienceVincent - The Podcasters Studio
Listener Pick of the WeekWink - DuckDuckGoJosh - Introduction to Solid State Chemistry
Send your virology questions and comments (email or mp3 file) to [email protected]. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley
Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.
Links for this episode:Alan - Dance your Ph.D.Rich - Angel of Death by Gareth WilliamsVincent - Why herpesvirus is good for you (Virgin lab)
Listener Pick of the WeekLuis - VBORNET maps
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and W. Ian Lipkin
Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Alan - Insane in the Chromatophores (Vimeo)Rich - Golden Goose AwardsKathy - Euler's Disk (YouTube)Vincent - Ignorance: How it Drives Science by Stuart Firestein
Listener Pick of the WeekAdam - Leigh Van Valen
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses.
Links for this episode:Alan - Getting Better: 200 Years of MedicineRich - Khan AcademyKathy - Vi HartVincent - Tweet Keeper
Listener Pick of the WeekDiane - The Way We Fall by Megan CreweStephen - Amateur Micrography
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and Philip I. Marcus
Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Kathy Spindler, Mark Stenglein, and Joseph DeRisi
The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease.
Links for this episode:Mark - The Slow Mo Guys (Fly eats fly)Dickson - I'm being eaten by a boa constrictor by Shel SilversteinAlan - MMWR: First 30 years onlineRich - Giant python in Everglades and California Academy of SciencesKathy - Darwin finch genome sequenceVincent - Microbiology at Mt. Sinai
Listener Pick of the WeekRenato - Security Now podcastRobin - The WeatherChad - Rare protozoan from sludge (ScienceDaily)
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Ken Stedman
The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Ken - The Edge of Life trailer and Facebook pageDickson - The Cognitive Style of Powerpoint by Edward TufteAlan - SEMs of insects and spiders via Steve GschmeissnerRich - Curiosity Has Landed (Wiki mission summary)Vincent - Curiosity's Seven Minutes of Terror (YouTube)
Listener Pick of the WeekLance - The Vaccine Confidence Project and Immune response video (YouTube)Anat - Beautiful Science
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager.
Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer
Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Rich - Benjamin Franklin: An American Life by Walter IsaacsonVincent - Biochemistry Revealed
Listener Pick of the WeekMatlock - The BioDigital HumanMatt - Scientists create jellyfish from rat cells
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Alan - The Microbial Olympics (supplementary information)Rich - PharmaJet needle free injection systemVincent - Microbes and Evolution by Roberto Kolter and Stanley Maloy (paperback and Kindle)
Listener Pick of the WeekVarun - Agile Gene by Matt RidleySizun - Plague IncRicardo - TED-EDKristopher - Ed Yong on Econtalk
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche
Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:Alan - H5N1 genetic changes inventoryRich - Mythbusters: Diet Coke and Mentos (YouTube channel)Nissin - The Pox and the Covenant by Tony Williams, and Tired of War by Tereza BatistaVincent - FAQ: The 'snake bite' portion of your thesis defense
Listener Pick of the WeekGopal - All's not fair in science and publishingLuis - The Origin of AIDS by Jacques Pepin (Nature review)Sven - Visualizing information flow in science
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol.
Links for this episode:Kathy - Wind mapVincent - The A-Z of Epidemiology (YouTube)
Listener Pick of the WeekKristoffer - How to read a paperNeva - Electricity from viruses
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers.
Links for this episode:Hosts: Vincent Racaniello, Massimo Palmarini, John MacLauchlan, Emma Thomson, and Hande Harmanci.
Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus.
Links for this episode:Vincent - Microbe art
Listener Pick of the WeekJudi - Cell Imaging (Mac App Store)
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period.
Links for this episode:Rich - The Checklist by Atul GawandeVincent - Artologica
Listener Pick of the WeekDavid - Cracking your genetic code (Nova)Josh - The nuclearization of biology is a threat to health and security (pdf)
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more.
Links for this episode:Alan - World Wide Lightning Location NetworkRich - Steve Jobs by Walter IsaacsonVincent - The Ocelloid
Listener Pick of the Weeklafrenchfille - whatshouldwecallgradschoolNeva - Antiviral drugs by Carl ZimmerSergio - APSnet
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses.
Links for this episode:Sarah - Breasts: A Natural and Unnatural History by Florence WilliamsAndrew - The Strangest Man by Graham FarmeloVincent - Gates Grand Challenges in Global Health awards
Listener Pick of the WeekEd - Pursuit of Light (YouTube); MRC Biomedical Picture of the Day; It's okay to be smart
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust.
Links for this episode:Alan - PubMed PubReMinerRich - Intentional Blindness (YouTube)Vincent - Vaccine infographic
Listener Pick of the WeekKen - Wattpad
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses.
Links for this episode:Connor - Microbiology Twitter journal clubAlan - Where the Wild Types Are (YouTube)Rich - May 14th: Smallpox vaccination dayDickson - Searching for pore-fection (Science)Vincent - RRResearch
Listener Pick of the WeekStephen - Every Major's Terrible (xkcd)
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Michael J. Imperiale
Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB.
Links for this episode:Alan - 18th century shipping mappedRich - Brave New World by Aldous HuxleyVincent - Air France 447 (Telegraph)
Listener Pick of the WeekHosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions.
Links for this episode:Kathy - Astronomy Picture of the Day (especially this and this)Rich - Tom Lehrer Element Song (YouTube)Vincent - Albert B. Sabin Archives
Listener Pick of the WeekMark - Netter's Infectious Diseases by Elaine C. Jong and Dennis L. StevensRichard - Germs, Genes & Civilization by David P. Clark
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA.
Links for this episode:Alan - Micro Empire (Vimeo)Rich - Census of marine lifeVincent - Pinterest
Listener Pick of the WeekMark - The Secret Life of Plankton (YouTube)
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Gertrud Radu
Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps.
Links for this episode:Gertrud - Bat on a plane! (MMWR)Alan - The Rings of Earth (YouTube)Rich - Giant Magellan telescopeVincent - Hepatitis C new drug pipeline
Listener Pick of the WeekRicardo - Evolution: The Natural History of Animal SkeletonsPeter - Self-assembly line (YouTube)
The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue.
Links for this episode:Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)Alan - The Winged Scourge (YouTube)Rich - Deepsea ChallengeVincent - Why did a US advisory board reverse its stance? (Ed Yong)
Listener Pick of the WeekSasha - Microfluidic FutureAdam - The ConversationJim - ENIAC Programmers Project
A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland.
Links for this episode:Connor - Wellcome Trust Science Writing Prize 2012Vincent - Thoughts on academic scientists giving media interviews
Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more.
Links for this episode:Rich - Alan Alda's Flame Challenge (NY Times article, Science editorial)Alan - ChronoZoomVincent - Academic Publishing is Broken by Michael P. Taylor
Listener Pick of the Week
Joel - Fighting a dengue outbreak by Tyler M. Sharp (parts one and two)Sven-Urban - Fooled by Randomness and The Black Swan by Nassim Nicholas Taleb
Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization.
Links for this episode:Matt - Phage and the Origins of Molecular BiologyAlan - Digital Imagine InstituteVincent - iPad apps Goodreader and Notability
Listener Pick of the Week
Jane -Smoking Ears and Screaming Teeth by Trevor Norton
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis.
Links for this episode:Rich - NOAA Buoy DataAlan - Autism's False Prophets by Paul OffitVincent - Media Mining
Listener Pick of the Week
Mark - How the West fueled the AIDS epidemicHenry - RegenesisRick - Biopunk: DIY scientists hack the software of life by Marcus Wohlsen
The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats.
Links for this episode:
Weekly Science Picks
Ashlee – AskScience (Reddit)Michael - HealthMap (iPhone and Android app)Rich – H5N1 research discussion at ASMBiodefenseAlan – El Yunque National ForestVincent – The Journal of Global Health
Listener Pick of the Week
Judi – NSF visualization challenge
Send your virology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss atmicrobeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and Kathy Spindler
Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.
Links for this episode:Matt joins the TWiVarians to review virus production in single cells and single virion genomics.
Links for this episode:Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.
Links for this episode:Michael and the TWiV team review epidemiology basics, including fatality ratios.
Links for this episode:Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.
Links for this episode:The complete TWiVome deconstructs the movie Contagion.
Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.
Links for this episode:Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.
Vincent, Alan, and Rich review ten compelling virology stories of 2011.
Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.
Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.
Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.
The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi's sarcoma herpesvirus and Merkel cell polyomavirus.
Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.
Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.
A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.
Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.
Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begamoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia, São Paulo, Brazil.
Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.
Vincent, Alan, and Rich review an outbreak of rabies in arctic foxes and reindeer in Norway, and a prion that makes you go antiviral.
Vincent, Alan, and Rich cover the virome of raw sewage, and a baculovirus gene that causes caterpillars to climb to their doom.
Vincent, Alan, and Rich review questions and comments from TWiV listeners.
Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.
Vincent, Rich, Mark, and Trine discuss science and medicine in journalism and the eradication of poliovirus at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).
Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.
The complete TWiV gang discusses the use of Wolbachia to control mosquito-borne infections.
Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.
Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.
Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.
Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.
Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.
Matt Evans joins Vincent, Dickson, Alan, and Rich to deconstruct a mouse model for hepatitis C virus infection.
Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.
Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.
The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.
Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.
Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.
Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.
Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.
Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.
Vincent, Alan, and Dickson chat with Brad Thompson, CEO of Oncolytics Biotech, about using reovirus to treat cancer.
Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication.
Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.
Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.
Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.
Virologist Michelle Ozbun and the TWiV team review the biology of human papillomaviruses.
This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.
Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus.
Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.
The complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.
A conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle.
Hosts: Vincent Racaniello, Rich Condit, and Ed Niles
Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government.
Become a patron of TWiV!
Links for this episode:Rich - Dark Sun: The Making of the Hydrogen Bombby Richard Rhodes Ed - Tenth anniversary of the human genome at Science MagazineVincent - Poliovirus fights back
Send your virology questions and comments to [email protected].
Vincent and journalist David Tuller converse about the state of science reporting by the press.
Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more.
Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild.
Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.
Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication inAedes aegypti with a Wolbachia symbiont.
Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.
Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.
Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.
The TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it.
Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.
Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses.
Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.
Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more.
Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.
Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.
The entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.
Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.
A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.
Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
On episode #99 of the podcast This Week in Virology, Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.
Host links Vincent Racaniello
Links for this episode:On episode #98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.
On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.
On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.
On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode:Alan - Families Fighting Flu Rich - Food, Inc. Dickson - Fuel Vincent - MIT Open Courseware Michael - Waiting for Superman and Can Science Feed the World? (Nature)
On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh
Links for this episode:Alan - The new Federal Register site (see also regulations.gov) Rich - The Florida Museum of Nautural History Butterfly Rainforest Vincent - JoVE, the Journal of Visualized Experiments
On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:Alan - Southern Fried Science Rich - Tree of Life web project Vincent - Dickson Despommier at Big Think
Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets.
Host links Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck
Links for this episode:Marilyn - Viruses in the faecal microbiota of monozygotic twins and their mothers (Nature) Rich - The Known Universe by the American Museum of Natural History Vincent - The Red Queen by Matt Ridley (thanks, Jesper!)
On episode #91 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson
Links for this episode:Welkin - Advice for a Young Investigator by Santiago Ramon y Cajal Rich - How microbes define and defend us Dickson - H1N1 virus lacks 1918 virus killer protein Alan - The Xtal Set Society Vincent - Antibodies and the quest for an AIDS vaccine
On episode #90 of the podcast This Week in Virology, Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Eric F. Donaldson
Links for this episode:Eric - Year of Darwin by Sean Carroll Rich - March of the Penguins Alan - Standing-height desks Vincent - DengueWatch (thanks Richard!)
On episode #89 of the podcast This Week in Virology, Vincent and Alan review recent findings on the association of the retrovirus XMRV with ME/CFS, reassortment of 2009 pandemic H1N1 influenza virus in swine, and where influenza viruses travel in the off-season.
Host links Vincent Racaniello and Alan Dove
Links for this episode:Alan - Tree of Life graphic Vincent - TEDx Oil Spill
On episode #88 of the podcast This Week in Virology, Vincent, Alan, and Marc discuss using a virus for beetle control, RNA based gene therapy for AIDS, and reconstitution of a endogenous human retrovirus.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode:Marc - Apple iPad as a tool for writing, with Papers, Pages, and GoodReader Alan - The Bacterium and the Bacteriophage Vincent - Naturally Obsessed (thanks, Sharon!)
On episode #87 of the podcast This Week in Virology, Vincent, Alan, and Rich hear from Professor Graham Hatfull how students in the Phage Hunters Integrating Research and Education (PHIRE) program learn about scientific inquiry by doing research on bacteriophages.
Host links Vincent Racaniello, Rich Condit, Alan Dove, and Graham Hatfull
Links for this episode:Rich - CDC Public Health Image LibraryVincent - March of the Microbes by John L. IngrahamAlan – Great Microbiologists – A Lego MovieGraham – Coral Reefs in the Microbial Seas by Forest Rohwer
On episode #86 of the podcast This Week in Virology, Vincent and Rich travel to the Blood Systems Research Institute in San Francisco to speak with Eric Delwart about his work on virus discovery.
Host links Vincent Racaniello, Rich Condit, and Eric Delwart
Links for this episode:Rich - Google Crisis Response - Gulf of Mexico Oil Spill Vincent - HHMI resources for teachers and students (thanks, Jim!) Eric - Vaccine by Arthur Allen
On episode #85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses.
Host links Vincent Racaniello and Michael Gale
Links for this episode:On episode #84 of the podcast This Week in Virology, Vincent and Rich spoke with Dave Bloom and Grant McFadden about their work on herpesviruses and poxviruses in this episode recorded before an audience at the University of Florida, Gainesville - home of the Gators.
Host links Vincent Racaniello, Rich Condit, Dave Bloom, and Grant McFadden
Links for this episode:Rich - Charles F. Littlewood photographs Vincent - Not so humble pie (thanks, Sophie!) Grant - The Strangest Man by Graham Farmelo David - Is Parkinson's Disease a prion disorder?
On episode #83 of the podcast This Week in Virology, Vincent, Alan, Rich, and special guest Dr. Kirsten Sanford talk about her career in science media, then consider whether smallpox eradication led to the AIDS pandemic, high fidelity RNA synthesis, and a new Ebola virus vaccine.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Kirsten Sanford
Links for this episode:Alan - Evernote Rich - The Knife Man by Wendy Moore Vincent - The Pump Handle
On episode #82 of the podcast This Week in Virology, Vincent and Rich talk about how thymic selection of T cells might lead to better control of HIV-1 infection, and a mouse model for severe antibody-induced dengue virus disease.
Host links Vincent Racaniello and Rich Condit
Links for this episode:Rich The Mold in Dr. Florey's Coat: The Story of the Penicillin Miracle by Eric Lax Vincent Proteopedia (thanks, Erik!)
On episode #81 of the podcast This Week in Virology, Vincent and Rich answer listener questions on viruses and gluten allergy, RNA silencing, influenza virus, herpes simplex virus, HIV/AIDS, chronic fatigue syndrome, manicure salons, and the koala tea of Marseilles.
Host links Vincent Racaniello and Rich Condit
Links for this episode:Rich Google Chrome browser 'speed test' (and how it was made) Vincent Inside the Outbreaks by Mark Pendergrast
On episode #80 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Michael Bouchard about hepatitis B virus discovery, replication, and pathogenesis.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Michael Bouchard
Links for this episode:Rich PBS Frontline: The Vaccine War Alan Readability Vincent Starswarm by Jerry Pournelle
On episode #79 of the podcast This Week in Virology, Vincent and Alan converse about making published science accessible to everyone, global eradication of poliomyelitis, and whether a plant virus can cause disease in humans.
Host links Vincent Racaniello and Alan Dove
Links for this episode:On episode #78 of the podcast This Week in Virology, Vincent, Alan, Dickson, and Rich talk about treating arthritis with a tanapox virus protein, Darwinian evolution of prions in cell culture, and the connection between cold weather fronts and outbreaks of avian H5N1 influenza in Europe.
Host links Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit
Links for this episode:Dickson Medical News Today: Infectious Diseases and Eaarth by Bill McKibben Rich U can with Beakman and Jax by Jok Church Alan UnderwaterTimes Vincent The Reef Tank
On episode #77 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:Rich The Way We Work by David Macaulay Alan DimDim Vincent Polio: An American Story by David Oshinsky
On episode #76 of the podcast This Week in Virology, Vincent speaks with Stephen Goff about the origin of the retrovirus XMRV and its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello and Stephen Goff
Links for this episode:On episode #75 of the podcast This Week in Virology, Vincent, Alan, and Matt review contamination of Rotarix with circovirus DNA, antigenic similarity between 1918 and 2009 H1N1 influenza, a collection of rabies reports, and chicken pox mistaken for smallpox in Uganda.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode:Matt Bitesize BioAlan Free printable graph paper (see also doane paper)Vincent Avian Flu Diary
On episode #74 of the podcast This Week in Virology, Vincent speaks with Adolfo Garcia-Sastre about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus.
Host links Vincent Racaniello and Adolfo Garcia-Sastre
Links for this episode:On episode #73 of the podcast This Week in Virology, Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes.
Host links Vincent Racaniello, Dickson Despommier, and Rich Condit
Links for this episode:Dickson Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy (NEJM and NY Times) Rich Invisible Frontiers: The Race to Synthesize a Human Gene by Stephen Hall Vincent Conference on Retroviruses and Opportunistic Infections - videocasts
On episode #72 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich explain CRISPR/Cas, the immune system of bacteria and archaea, how novel viruses are discovered by deep sequencing of small RNAs, and the relationship between dry weather and outbreaks of West Nile virus infection.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode:Dickson Scientist as Chef by Dickson Despommier (pdf) Alan Networked Organisms and Habitats (NOAH) iPhone app Rich Never Cry Wolf by Farley Mowat Vincent The Dish
On episode #71 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode:Dickson and Alan NSF/AAAS Science and Engineering Visualization Challenge Rich Foundation by Issac Asimov Vincent Natural Obsessions by Natalie Angier
On episode #70 of the podcast This Week in Virology, Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host to maximize its spread, a new way to preserve viral vaccines at tropical temperatures, and the continuing story of XMRV and chronic fatigue syndrome.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode:Dickson Chemical Ecology - edited by Thomas Eisner and Jerrold MeinwaldAlan Scripps Center for Mass Spectrometry Vincent Folding@home (thanks Jesper!)
On episode #69 of the podcast This Week in Virology, Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:Rich John Moran Florida Nature PhotographyAlan Periodic Table of Videos Vincent The Protein Databank Educational Resources
On episode #68 of the podcast This Week in Virology, Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:Rich Foundations of Virology - PowerPoint by Frederick A. Murphy (bio/interview pdf)Alan Spoonful of Medicine - Nature Medicine blog Vincent The Feynman Lectures (thanks Ilya!)
On episode #67 of the podcast This Week in Virology, Vincent, Alan, and Marc Pelletier talk about chronic wasting disease of deer caused by prions, blocking the semen-derived enhancer of HIV infection with surfen, and making green transgenic rabbits using a lentiviral vector.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode:Marc Association of Science-Technology Centers Passport ProgramAlan ZooniverseVincent Grand Rounds at the Mailman School of Public Health
On episode #66 of the podcast This Week in Virology, Vincent and Dickson continue virology 101 with a discussion of information flow from RNA to DNA, a process known as reverse transcription, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:On episode #65 of the podcast This Week in Virology, Vincent, Alan, and Matthew Frieman Vincent, Alan, and Matt discuss a project to study the RNA virome of Northeastern American bats, failure to detect XMRV in UK chronic fatigue syndrome patients, and DNA of bornavirus, an RNA virus, in mammalian genomes.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode:On episode #64 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss ten compelling virology stories of 2009.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Ten virology stories of 2009:Picture book on viruses for kids (Thanks Soraia!)
On episode #63 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about US government contract for freeze-dried smallpox vaccine, red squirrels in the UK threatened by poxvirus, and Marseillevirus, another DNA virus from amoebae built for comfort and speed.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:On episode #62 of the podcast This Week in Virology, Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode:On episode 61 of the podcast "This Week in Virology", Vincent and Dick muse about the symbiotic bacterium,Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:Vincent and Dickson continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.
Host links Vincent Racaniello, Alan Dove, Rich Condit, Gustavo Palacios, and Mady Hornig
Links for this episode:
Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake.
Host links Vincent Racaniello, Dick Despommier, Alan Dove, and Joshua Stillman
Links for this episode:
Vincent visits Scotch Plains – Fanwood High School and talks about viruses with high school biology students.
Host links: Vincent Racaniello
Links for this episode:
Vincent, Dick, Alan, and Cliff answer questions from listeners on swine influenza origins, transmission, virulence, and vaccines, HIV and AIDS, and more.
Host links: Vincent Racaniello, Dick Despommier, Alan Dove, and Cliff Mintz
Links for this episode:
Dick 27" iMac and Powers of Ten by Philip Morrison and Phyllis MorrisonAlan ImageMagickCliff ePatient Connections 2009Vincent Cell size and scale
The largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on flu susceptibility, and transmission of H1N1 influenza to a pet ferret.
Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit
Links for this episode:Dick Nikon photomicroscopy contest winners at SciAm (Dick's article on vertical farming)Alan Make:Rich BBC's Planet Earth (DVD at Amazon)Jason The Collider, the Particle and a Theory About FateVincent An Epidemic of Fear and Misinformants at Wired Magazine
Vincent speaks with Lynn Enquist about his career in virology, moving from academia to industry and back. Along the way he did pioneering research on bacteriophage, participated in the birth of recombinant DNA technology, and studied herpesviruses.
Links for this episode:
Lynn Francis Crick: Hunter of Life's Secrets by Robert OlbyVincent ViralZone
Vincent, Dick, and Alan talk about Nobel prizes for telomere research, bacteriophages that protect aphids from wasps, salicylates and pandemic influenza mortality, and hand washing.
Links for this episode:Alan sciencelineDick Younger by Judith Sulzberger MDVincent FluView
Vincent and Dr. Scott Hammer talk about different types of AIDS vaccines and how they are tested in clinical trials.
Links for this episode:Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan.
Links for this episode:Alan Bat Rabies and Other Lyssavirus InfectionsDick Boosting Vaccines: The Power of Adjuvants (Scientific American; subscription required)Vincent The Ig Nobel Prizes by Marc Abrahams
Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer.
Links for this episode:Jason Glass MicrobiologyVincent FluWeb Influenza Historical Resources Database
Vincent and Dick continue Virology 101 with a discussion of the seven different types of viral genomes, and how to use the pathway to mRNA to understand viral replication.
Links for this episode:
Dick Discovery Channel: Planet GreenVincent Influenza videos at BigThink: one, two, three, four, five, six
Vincent, Dick, Alan and Rich revisit a vaccinia virus lab accident and viral vaccines produced in plants, then talk about an iPhone app to track infectious diseases, flying foxes, and an inhaled measles vaccine.
Links for this episode:Rich Stumbling on Happiness by Daniel GilbertDick Eliot Porter at the Carter Museum and bookstore at AmazonAlan Dr. Clarke's H1N1 rap at the HHS sponsored YouTube contestVincent Coast to Coast Bio Podcast
Vincent and Dick discuss influenza virus-like particle vaccines produced in insect and plant cells, rapid sharing of influenza research, and answer listener questions about cytomegalovirus, viral evolution and symbiosis and much more.
Links for this episode:Vincent BionumbersDick Ocean: An Illustrated Atlas by Sylvia A. Earle, Linda K. Glover
Vincent and Dick continue virology 101 with a discussion of virus entry into cells, then answer reader email on colony collapse disorder and viruses that confer a benefit to their host.
Links for this episode:Vincent PLoS PearlsDick West Nile virus website at CDC
Vincent, Dick, Alan, and Jennifer Drahos tackle the Hendra virus disease outbreak in Australia, AIDS-like disease in wild chimps, return of polio type 2 in Nigeria, the influenza pandemic wave, and rabies in three countries.
Links for this episode:Jennifer Art of Science 2009 Vincent Nobel Intent Dick Diversity of Life by EO Wilson Alan MediaWiki (install tips )
Vincent, Dick, Alan, and Jennifer Drahos consider Marburg virus in Egyptian fruit bats, bacterial citrus pathogen found in shipping facility, canine parvovirus in Michigan, Relenza-resistant influenza virus, new HIV from gorillas, and public engagement on H1N1 immunization program.
Links for this episode:Jennifer Piled Higher and Deeper (PhD Comics) Vincent Giant Microbes (thanks Stephen!) Dick Virology in the 21st Century Alan Annals of the Former World by John McPhee
Vincent and Dick explain virus classification, and revisit the 1976 swine flu immunization campaign and Guillain-Barré syndrome.
Links for this episode:
Weekly Science Picks
Dick Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth by Lynn Margulis and Karlene V. SchwartzVincent A Genetic Switch by Mark Ptashne
Vincent, Dick, Alan, and Delthia Ricks discuss a new influenza virus-like particle vaccine, dog flu, ultrasensitive pen-sized virus detector, imported rabies in the US, Crimean-Congo hemorrhagic fever, and next season’s flu vaccines.
Hosts Vincent Racaniello, Dick Despommier, Alan Dove, and Delthia Ricks
Links for this episode:
Weekly Science Picks
Delthia 100 questions and answers about influenza by Delthia Ricks Alan Tinychat Dick Mythbusters Vincent Effect Measure
In episode 41 of "This Week in Virology", Vincent Racaniello, Dick Despommier, Alan Dove and Rich Condit chat about infectious salmon anemia virus, virus-resistant grapevines, virulence of pandemic H1N1 influenza virus, origin of 1918 influenza virus, holy water ban to halt influenza, frequency of human WU and KI polyomavirus infection, rabies in China, and host species of sin nombre virus.
Links for this episodeAlan For Love of Insects by Thomas EisnerRich Making of the Atomic Bomb by Richard RhodesDick Origin of Species by Charles Darwin Vincent Gallileoscope (thanks Zach!)
In episode 40 of "This Week in Virology", hosts Vincent Racaniello, Dick Despommier, and Alan Dove consider Reston ebolavirus in swine, historical perspective of H1N1 influenza virus emergence and circulation, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, transmission of H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 in Mexico.
Links for this episodeAlan Coming to Life by Christiane Nusslein-VolhardDick Monsters Inside Me from Discovery ChannelVincent Microbeworld
In episode 39 of This Week in Virology, hosts Vincent Racaniello and Dick Despommier discuss virus structure and answer listener questions.
Links for this episode
Dick Visual Explanations by Edward R. TufteVincent The Youngest Science by Lewis Thomas
In episode 38 of This Week in Virology, hosts Vincent Racaniello and Glenn Rall chat about koi herpesvirus, H1N1 influenza vaccine produced in insect cells, attack by a rabid raccoon, and measles.
Links for this episode:Weekly Science Picks
Glenn Riddled with Life by Marlene Zuk Vincent All the Virology on the WWW
In episode 37 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Eric Freed talk about vesivirus contamination of bioreactors, pandemic influenza, maximizing the effect of vaccination by targeting children, chikungunya virus, and open access scientific journals.
Links for this episode:Alan Forrest Mims (website) Vincent The Machinery of Life by David S. Goodsell
In episode 36 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Hamish Young discuss the 2009 influenza pandemic, first 2009 H1N1 vaccine, hunting mosquitoes with midges, vaccine-associated polio in India, and adenoviruses.
Links for this episode:Dick The World’s Water by Peter H. Gleick Hamish Guns, Germs, and Steel by Jared Diamond; Complications by Atul Gawande Alan Eurekalert Vincent Respectful Insolence
In episode 35 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Richard Kessin talk about Lujo virus, a new arenavirus, influenza, WHO rewriting pandemic rules, adjuvants, and a brief history of microbiology.
Links for this episode:Lujo virus, a new arenavirus
Is CDC too optimistic about influenza?
WHO to rewrite pandemic rules
Adjuvant at wikipedia
Avery, MacLeod, McCarty 50th anniversary ( pdf)
Dick Three papers on origins of infectious diseases (one, two, three) Rich An Imperfect Lens by Anne Roiphe Alan Zotero, a FireFox plugin Vincent e! Science News
In episode 34 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, and guest Stephen Morse discuss progressive vaccinia in a smallpox vaccinee, arsenic and influenza in mice, facemasks and flu transmission, and antigenic and genetic analyses of the new H1N1 influenza virus.
Links for this episode:Vincent, Alan, Dick, and Raul Andino live at ASM discussed cytomegalovirus infection and blood pressure, restriction of avian influenza viral replication at low temperature, first isolation of West Nile virus in PA, and current status of influenza.
Hosts: Vincent Racaniello, Alan Dove, Dick Despommier, and Raul Andino
Links for this episode:
Cytomegalovirus infection causes an increase of arterial blood pressure Avian influenza virus glycoproteins restrict virus replication at low temperature First West Nile virus isolation of the year in PA CDC press release of 18 May 2009 Glaxo's influenza vaccine with adjuvant NY Times article on Guillain-Barré and a more scientific view
Weekly Science Picks Dick - National Museum of the History of Science and Medicine, Leiden Alan - Beginning Mac OS X Programming Vincent - Vaccinated by Paul Offit Raul - HubbleSite
In episode 32 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Raul Rabadan converse about polio survivors in iron lungs, bocavirus, structure of mimivirus, and genome sequence analysis of influenza H1N1 viruses.
Links for this episode: Death of Marsha Mason, who lived 60 years in an iron lung First discovery of bocavirus in human stool Structural studies of the giant mimivirus Pandemic potential of H1N1 influenza virus Was swine flu a lab accident? Bloomberg and NY Times articles Hong Kong virologist says new H1N1 strain is ‘unstable’ Article by John Barry on site of origin of 1918 influenza
In episode 31 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Marc Pelletier summarize the past week’s influenza H1N1 activity, and discuss parvovirus infection of dogs and humans.
Weekly Science Picks Marc Celestia, an application Dick US Geological Survey website Alan Society for Amateur Scientists website Vincent Sneeze, an online game
On this special episode of This Week in Virology Vincent Racaniello and Dr. Peter Palese, noted influenza expert, discuss the origin and pandemic potential of the new H1N1 influenza virus.
In episode 30 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Hamish Young focus on the new H1N1 influenza virus, which originated in swine and is likely to be the next pandemic strain.
Science blog of the week: GermBlog by Dr. Harley Rotbart Science podcast pick of the week: Science and the City Science book of the week: The Swine Flu Affair: Decision-making on a Slippery Disease by by Richard E. Neustadt, Harvey V. Fineberg
In episode 29 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and Dick Despommier talk about insect and human dengue virus host proteins, equine vaccine for WNV and EEEV, return of swine flu to humans, spread of polio in Africa, and listener email.
Links for this episode:
Science blog of the week: Science-based medicine Science podcast pick of the week: WNYC’s Radio Lab Science book of the week: Flu by Gina Kolata
In episode 28 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier, and Eric F. Donaldson discuss a new test for influenza H5N1, poliovirus in Minnesota, Koala retrovirus, batteries made from viruses, and SARS.
Links for this episode:
Science blog of the week: The Great Beyond by Nature Science podcast pick of the week: Sorting Out Science Science book of the week: A Slot Machine, A Broken Test Tube by S.E. Luria (out of print - check your library)
In episode 27 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier, and Saul Silverstein revisit an ebola virus needlestick accident, and discuss the role of TLR3 in formation of Negri bodies, a New England college closed by norovirus gastroenteritis, hand, foot, and mouth disease outbreak in China, and the exit of herpes simplex virus from latency by synthesis of VP16.
Links for this episode:
Science blog of the week: Biocurious Science podcast pick of the week: NPR’s Science Friday Science book of the week: A Conspiracy of Cells by Michael Gold Dick’s pick: Andros Island Bonefish Club Saul’s pick: Secret Science Club
In episode 26 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Rich Condit converse about induction of polyomavirus replication in multiple sclerosis patients treated with the MS drug Tysabri, the extent of human polyomavirus infection, selection of influenza vaccines for the 2009-10 season, cowpox virus transmission from animals to humans, vaccinia-like virus infecting humans and cattle in Brasil, and poxviruses.
Links for this episode:
Science blog of the week: Coevolvers by Devin Drown Science podcast pick of the week: QuackCast Science book of the week: Listen to the Music: The Life of Hilary Koprowski by Roger Vaughan
In episode 25 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Luis Villarreal discuss rabies in Viet Nam and Angola, needle-stick infections with ebola virus and West Nile virus, and viral evolution.
Links for this episode:
Furious rabies after an atypical exposure
Rabies outbreak in Angola
Ebola virus needle stick injury in Germany
West Nile virus needle stick injury in South Africa
Antibody response to smallpox vaccine in humans (including Dr. Villarreal)
The chemical formula for polio virus is: C332, 652H492, 388N98, 245O131, 196P7, 501S2, 340. Because poliovirus is a quasispecies, the number of atoms is a population average.
Review article: Ten Reasons to Exclude Viruses from the Tree of Life
Origin and Evolution of Viruses, second edition, edited by Esteban Domingo
Origin of Group Identity by Luis Villarreal
Science blog of the week: Small Things Considered by Moselio Schaechter and Merry YouleScience podcast pick of the week: The Skeptics’ Guide to the UniverseScience book of the week: Viruses and the Evolution of Life by Luis Villarreal
Vincent, Alan, and Hamish Young discuss bacteriophages in viral vaccines, enteroviruses and diabetes, inhibition of Hendra and Nipah virus replication by the malaria drug chloroquine, and viroids.
Links for this episode:
Science blog of the week: The Weekly Virus Science podcast pick of the week: NIH Research Radio Podcast Science book of the week: Ahead of the Curve: David Baltimore’s Life in Science by Shane Crotty
Vincent, Dick, and Alan review a new macaque model for HIV-1 infection, a possible role for Epstein-Barr virus in multiple sclerosis, accidental release of H5N1 by a vaccine company, resistance of frogs to virus infection, and extreme virology - the biggest and smallest viruses and viral genomes.
Links for this episode:
Science blog of the week: H5N1 by Croft Science podcast pick of the week: MicrobeWorld video Science book of the week: Autism’s False Prophets by Paul A. Offit, MD (podcast with Dr. Ginger Campbell)
In episode 22 of This Week in Virology, host Vincent Racaniello and guest host Chris Upton, a professor in the Department of Biochemistry and Microbiology at the University of Victoria in Vancouver, Canada, converse about hepatitis B in India, AIDS gene therapy with a ribozyme, antibodies that neutralize many influenza virus strains, killing tumors with vaccinia virus, myxoma virus of rabbits, and the Viral Bioinformatics Resource Center.
Links in the episode indlude:
Science blog of the week: The VBRC blog by Chris Upton Science podcast pick of the week: Nova ScienceNow Science book of the week: The Hot Zone by Richard Preston
In episode 21 of This Week in Virology, hosts Vincent Racaniello, Dick Despommier, Alan Dove, and special guest Max Gottesman, discuss an unusual wasp-virus symbiosis, influenza transmission and absolute humidity, how mosquitoes survive Dengue virus infection, and viruses of bacteria.
Links in the episode indlude:
Science blog of the week: BioJobBlog by Cliff Mintz Science podcast pick of the week: Distillations - a weekly science podcast that brings you extracts from the past, present, and future of chemistry Science book of the week: The Life of a Virus by Andrea Creager
Vincent, Dick, Alan, and Matt Evans converse about TED, the Wakefield autism controversy, 99 rhinovirus sequences, Marburg in the USA, and hepatitis C virus.
Vincent and Alan discuss cap-snatching by the hantavirus N protein and the influenza virus endonuclease, HIV-1 and Ebola virus antagonism of tetherin, and influenza pneumonia.
Vincent, Dick, and Alan discuss adenovirus type 36 and obesity, new influenza antiviral drugs, viral hemorrhagic septicemia virus of fish, and Ebola virus in pigs and pig farmers in the Phillipines.
Vincent, Dick, and Saul talk about discoveries in virology that have had a major impact on the field.
Sem•i•nal (adjective): strongly influencing later developments. Note: There are two HPV vaccines on the market: Gardasil (quadrivalent, types 6, 11, 16, 18) and Cervarix (bivalent, types 16 and 18).
Links for this episode:
Gates Foundation donates to polio eradication effort. Testing a bivalent oral poliovirus vaccine in India. We played a clip from net@night episode 83. I wrote about Jonathan Swift’s ‘Animalcules’ on virology blog.
Science blog of the week: Research Blogging Science podcast pick of the week: Boston Museum of Science podcast Science book of the week: The Lives of a Cell: Notes of a Biology Watcher by Lewis Thomas
Vincent and Jeremy, in Saanen, Switzerland, review the 19th Challenge in Virology meeting, and implications of a new HIV-1 sequence from 1960 for the origin of AIDS.
Links for this episode:
NY Times article on Offit vaccine book. Nature paper on new 1960 HIV-1 sequence. Massive polio immunization in Pakistan. PLoS paper on T cell responses to HERVs in HIV-1 infection.
Science blog of the week: Eye on DNA by Dr. Hsien-Hsien Lei Science podcast pick of the week: Persiflager’s Infectious Disease Podcast Science book of the week: Microbe Hunters by by Paul de Kruif
Vincent, Dick, and Alan converse about hantavirus spread by large deer mice, why the 1918 influenza virus replicates in the lower respiratory tract, measles in Europe, and the growing resistance of influenza virus to antivirals.
Links for this episode:
MMWR, Morbidity and Mortality Weekly Report from CDC. Larger, older deer mice spread hantavirus. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Measles in Europe: an epidemiological assessment. Avian flu (H5N1) gaining resistance to antivirals. Times article on resistance to Tamiflu and analysis by virology blog. Angola widens border closure with DRC over Ebola.
Solutions, the iPhone/iPod Touch app to calculate molar solutions. Vaccine, the iPhone/iPod Touch app to determine vaccination schedules.
Science blog of the week: Molecule of the Day Science podcast pick of the week: Meet the Scientist by Merry Buckley Science book of the week: The Great Influenza by John M. Barry
The Origin of Species by Charles Darwin - published 150 years ago.
Vincent and Alan discuss a viral upper respiratory tract infection, transmission of H5N1 influenza virus, death of an HIV denialist, and the Ebola outbreak in the Democratic Republic of the Congo.
Links in this episode:
PLoS Pathogens paper on transmission of H5N1 influenza virus. Ebola outbreak in DRC reported by ProMedMail. Death of HIV denialist. BioCrowd, a network for bioscientists. Molecules, the iPhone/iPod Touch app to display molecules.
Science blog of the week: ViroBlogy Science podcast pick of the week: Astronomy Cast Science book of the week: The Cutter Incident by Paul A. Offit, MD
Vincent and Alan talk about President-elect Obama’s choices for his science advisors, SARS sensationalism, a new enteric picornavirus, and the top 10 virology stories of 2008.
Obama’s science advisors (Yahoo story) CDC RSS feed on influenza PNAS paper on a new enteric picornavirus
TWiV’s top 10 virology stories of 2008:
1. Nobel Prize in Medicine to Montagnier, Barré-Sinoussi, and zur Hausen 2. AIDS elite controllers partly explained 3. Cancellation of PAVE HIV-1 vaccine trial 4. Gut homing receptor for HIV-1 5. New Ebola strain 6. New mosquito virus 7. How mosquitoes survive virus infection 8. Mouse model for Chikungunya 9. Genome sequences of 150 avian influenza virus strains 10. Understanding the RS virus vaccine failure
Science blog of the week: Aetiology Science podcast pick of the week: biobytes Science book of the week: Principles of Virology, 3rd Edition by Flint, Enquist, Racaniello, and Skalka.
Vincent, Alan, and Angela discuss Kuru, prions in milk, ancient lentiviruses found in the chromosomes of lemurs, a respiratory syncytial virus vaccine failure in the 1960s, and recent outbreaks of H5N1 influenza in chickens.
Links for this episode:
D. Carleton Gajdusek obituary in the NY Times. We forgot to mention that he won the 1976 Nobel Prize in Medicine for his work on Kuru.
PLoS Pathogens article on prions in sheep milk.
PNAS article on endogenous lemur lentivirus
Nature Medicine article on the failed respiratory syncytial virus vaccine.
December 18 was the 100th anniversary of the discovery of poliovirus.
Science podcast pick of the week: Skepticality.
Science book of the week: Science Fictions: A Scientific Mystery, a Massive Cover-up and the Dark Legacy of Robert Gallo by John Crewdson.
Vincent, Alan, and Jeremy discuss why certain AIDS patients, called ‘elite controllers’ or ‘long-term non-progressors’, do not develop disease, why mosquitoes infected with Sindbis virus remain healthy, and the continuing outbreaks of norovirus gastroenteritis.
Links for this episode:
Immunity article on elite controllers.
PNAS article on protected mosquitoes.
The word quarantine comes from the seventeenth century Venetian quarantena, which means forty day period.
Science podcast pick of the week: The Mr. Science Show
Science book of the week: Arrowsmith by Sinclair Lewis. Click here to see a page from my Mother’s marked-up copy. She was a high school English teacher.
Vincent, DIck, and Alan chat about reconstruction of a bat SARS-like coronavirus, herpesviruses that are killing elephants in zoos, and a plan to eradicate AIDS in ten years.
Links for this episode:
The Virology Network at socialmedian.com.
The bat SARS-like coronavirus: scientific article in PNAS, and the Wired Science article.
NY Times Editorial on eradicating AIDS.
Herpesviruses killing elephants.
Science podcast pick of the week: Futures in Biotech.
Science book of the week: Principles of Molecular Virology, by AJ Cann.
Vincent and Dick recall the discovery of Lassa virus in Africa in 1969. A non-fictional account of the story, ‘Fever’, written by John G. Fuller and published in 1974, inspired Vincent to become a virologist. Part of the story took place at Columbia-Presbyterian Hospital (now Columbia University Medical Center), where both Vincent and Dick are employed. Dick remembers many of the key players in this medical drama.
Links for this episode:
Click here to view to cover of ‘Fever!’
Buy a used copy of ‘Fever!’ at Amazon.
Science podcast pick of the week: The Naked Scientists (iTunes link).
Vincent and Dick converse about warfare preventing immunization of 120,000 children in Afghanistan, bone marrow transplant curing AIDS patient, Google tracking flu, measles outbreak in Gibraltar, using viruses to make batteries, and small mosquitoes and Dengue.
Article on using viruses to make batteries (PubMed: Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes).
Science podcast pick of the week: NY Times Science Times (iTunes link).
Vincent, Dick, and Aidan discuss how viral infections play prominent roles in notable video games. Three games are discussed: World of Warcraft, Pandemic II, and Bioshock.
An article on how World of Warcraft became a model for the transmission of virus infections was published in Lancet Infectious Diseases. The title of the article is “The untapped potential of virtual game worlds to shed light on real world epidemics.”
After we did the netcast we learned of a game for the iPhone called ‘Virus’. In this game your body is infected with a virus, and you must clear the infection by controlling white blood cells. The game is at the iTunes App store.
Science podcast pick of the week: MicrobiologyBytes.
TWiV is now part of Sciencepodcasters.
Hosts: Vincent Racaniello and Dickson Despommier
Dickson was at Pop!Tech last week.
Neal Stephenson’s Cryptonomicon.
US Geological Survey Disease Maps.
CDC page on Hendra and Nipah viruses.
The flying fox (Google image search).
Vincent’s virology course.
Vincent’s texbook is Principles of Virology, third edition, ASM Press (available December 2008).
Science podcast pick of the week: Brain Science Podcast.
Host: Vincent Racaniello
Special guest: Saul Silverstein
Dickson Despommier is away this week at Pop!Tech.
Hosts: Vincent Racaniello and Dickson Despommier
CDC page on rabies
Dick’s Ecology 101 course
Ecotone defined
Negri bodies defined (down on the page)
Hosts: Vincent Racaniello and Dickson Despommier
Article on the mortgage crisis and West Nile virus in Emerging Infectious Diseases.
Environment-oriented review of Dengue.
Dengue page at the World Health Organization.
Hosts: Vincent Racaniello and Dickson Despommier
polioeradication.org for the latest information on the global state of polio.
Abstract of the Science article on engineering a new polio vaccine: “Virus attenuation by genome-scale changes in codon pair bias”.
Hosts: Vincent Racaniello and Dickson Despommier.
Buy “West Nile Story” by Dickson Despommier.
ProMed Mail. The global reporting system for outbreaks of emerging infectious disease.
PubMed. A service of the National Library of Medicine, includes over 14 million citations for biomedical articles back to the 1950s.
West Nile page at Centers for Disease Control and Prevention. Great maps of where the virus has been found.
En liten tjänst av I'm With Friends. Finns även på engelska.