TWiV 1140: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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• Measles transmission after secondary vaccination failure (Emerg Inf Dis)
• Mpox public health emergency of international concern (WHO)
• First case of new mpox strain outside of Africa (Reuters)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Where to get pemgarda (Pemgarda
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• Individual monoclonal antibodies against SARS-CoV-2 should be used (CID)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID science, research and policy (Nature Medicine)
• Measurements of prior SARS-CoV-2 infection and postacute sequelae by the clinical laboratory (Annals of Internal Medicine)
• Risk factors for long COVID syndrome in postmenopausal women with previous SARS-CoV-2 infections (Annals of Epidemiology)
• New studies estimate long-COVID rates, identify risk factors (CIDRAP)
• Monitoring long COVID via telemedicine (PLoS One)
• Letters read on TWiV 1140
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]