TWiV 714: The shape of spike with Jason McLellan

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

Guest: Jason McLellan

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Links for this episode

• Prefusion spike structure (Science)
• Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer
• Novavax COVID-19 vaccine phase 3 results (Novavax)
• J&J COVID-19 vaccine phase 3 results (J&J)
• B.1.1.7 has been in the US since November 2019 (virological.org)
• NERVTAG report on B.1.1.7 virulence (pdf)
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Pandemic Pivot and Tuba Skinny Alan – Technological challenges in vaccine rollout Rich – I was lucky to find this vaccine anywhere Vincent – Lady Gaga’s MIXED METER Star Spangled Banner?!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]