TWiV 751: Sputnik spat and furin in ferrets

TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Links for this episode

• ASV vaccine town halls
• Brazil rejects Gamaleya vaccine (Sci Transl Med)
• Russian vaccine behavior (Sci Transl Med)
• Is Gamaleya vaccine safe? (Science)
• Furin cleavage site in replication and transmission (Nat Micro)
• Furin site loss attenuates pathogenesis (Nature)
• Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]