TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin

In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.

Hosts: Daniel Griffin and Vincent Racaniello

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• Variant updates (CDC)
• List of diagnostic kits (Global Fund, pdf)
• B1.1.529 escapes most antibodies (bioRxiv)
• mRNA vaccine third dose and Omicron (medRxiv)
• Outpatient strategies children and adolescents (AAP)
• Memory B cells persist in elderly (J Clin Invest)
• mRNA booster effect against Delta (Clin Inf Dis)
• Azithromycin meta-analysis (J Antimicrob Chemo)
• High-flow oxygen vs intubation (JAMA)
• Therapeutic anticoagulation (Ann Int Med)
• Africa cases surge (CIDRAP)
• Letters read on TWiV 843
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]