Do fetuses care about what their mothers eat? When do spouses cheat? Does the use of social media predict depression and anxiety? How can we understand and address older adults’ loneliness? Some of the top articles published in the APS journals in 2022 explored these questions and much more. In this conversation, Ludmila Nunes talks with Amy Drew, who heads up APS’s journals team, for a countdown of the most impactful articles published in 2022.