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Witness History: Witness Archive 2016

Recreating Down Syndrome in Mice

9 min • 8 december 2016

In 2005 British scientist Elizabeth Fisher and a colleague successfully transplanted a human chromosome into a mouse for the first time. It transformed medical research into the genetic condition Down Syndrome that affects millions of people worldwide. Professor Fisher tells Louise Hidalgo about the challenges researchers faced and their thirteen-year struggle to create the first Down Syndrome mouse.

Photo: Science Photo Library

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