TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.
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Links for this episode
Emergency drug use during a pandemic (Cell) Muscle-directed AAV capsids (Cell) Designer AAV muscles up (Cell) Letters read on TWiV 812 Timestamps by Jolene. Thanks!
Dickson - Sid Caesar - The German General
Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life
Rich - Seek by iNaturalist
Alan - The hard part of making a game is ... everything
Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.
Become a patron of TWiV!Links for this episode Data on Pfizer-BioNTech in 5-12 year olds (Pfizer) Safety of additional vaccine dose (MMWR) Oklahoma reinfection rates (OK DOH) Regencov outcomes (NEJM) Pfizer protease inhibitor trial (Pfizer) WHO recommends antibody therapy (Hosp Health) Tocilizumab use in hospitalized patients (Resp Care) Long COVID (PLoS Medicine) Letters read on TWiV 811 Timestamps by Jolene. Thanks!
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.
Become a patron of TWiV!Links for this episode mRNA vaccines, a novel technology (Cell) Proton gradient in giant virus (ISME J) Tomograms of Pandoravirus massiliensis Pandoraviruses are not alive (virology blog) Letters read on TWiV 810 Timestamps by Jolene. Thanks! Weekly Picks
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.
Become a patron of TWiV!Links for this episode SARS-CoV-2 like viruses from Laotian bats (Res Sq) Herpesvirus in rabies endemic vampire bats (Nat Comm) Letters read on TWiV 809 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? George Carlin: ?Stuff?
Amy ? The best of me by David Sedaris
Rich ? You could have a secret twin (but not the way you think)
Alan ? Nuclear powered Gameboy
Vincent ? No, Vaccinated People Are Not ?Just as Likely? to Spread the Coronavirus as Unvaccinated People by Craig Spencer
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens.
Become a patron of TWiV!Links for this episode Pfizer phase III results in 5-11 year olds (Pfizer) FDA authorizes booster (FDA) V-safe vaccine pregnancy registry (CDC) High antibody levels in cord blood (Am J Ob Gyn) mRNA vaccines compared (MMWR) Effectiveness of single shot J&J (medRxiv) J&J booster results (J&J) EUA expansion for Lilly mAbs (Lilly) Remdesivir reduces hospitalization risk (Gilead) DisCoVeRy on Remdesivir (Lancet) Prophylactic anticoagulant dosing (Eur Heart J) Letters read on TWiV 808 Timestamps by Jolene. Thanks!
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic.
Become a patron of TWiV!Links for this episode Vaccine nationalism and control of the pandemic (Science) Vaccine sharing app Dynamics of SARS-CoV-2 simulation Dynamics of vaccination simulation Vaccine effectiveness against hospitalization (MMWR) Letters read on TWiV 807 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Ernie Kovaks-Nairobi Trio
Brianne ? XKCD Summarizes this Episode
Rich ? Texas Coronavirus Antibody REsponse Survey (CARES) (Dashboard)
Vincent ? Elmer Pfefferkorn
Catherine ? A Life on Our Planet
Attila ? How to improve your chances of nudging the vaccine hesitant away from hesitancy and toward vaccinationIntro music is by Ronald Jenke
Send your virology questions and comments to [email protected]
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa.
Become a patron of TWiV!Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Updated mask guidance (CDC) Transmission to masked and unmasked (MMWR) Daily testing in schools (Lancet) High barrier to mAb escape (bioRxiv) Boosters not needed (Lancet) Distribution system for mAbs (HHS) Steroids in non-oxygen requiring patients (Int J Med) Grants for long COVID (NIH) Genomic surveillance in Africa (Science) Letters read on TWiV 806 Timestamps by Jolene. Thanks!
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant.
Become a patron of TWiV!Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune evasion (Nature) Epidemiologically linked COVID-19 outbreaks (MMWR) Letters read on TWiV 805 Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? Sloan Foundation Theater
Kathy ? COVID vaccines work, even if you don?t have side effects lay article primary article
Rich ? Science Alone Can?t Heal a Sick Society by Jay S. Kaufman
Vincent ? Sandra Black SciArt
Ruth ? Radio Lento podcast
Virus hunter Mya Breitbart joins TWiV to describe her laboratory?s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more.
Guest: Mya Breitbart
Become a patron of TWiV!Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS Path) Environmental DNA in marine community (Nat Comm) Viral community of freshwater springs (mBio) Phage puppet masters in the oceans (Nat Micro) Letters read on TWiV 804 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Official-Droodles-Home
Alan ? The 31st First Annual Ig Nobel Prize Ceremony video (and the text version)
Vincent ? Biden?s federal and business vaccine mandates
Anonymous ? The Ivermectin Episode ? Behind the Bastards
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease.Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiV!Links for this episode Overlooked shortcomings of observational studies (Op For Inf Dis) Guidelines for clinical management (Op For Inf Dis) ER visits and hospitalization among children (MMWR) Hospitalization of adolescents (MMWR) Seroprevalence in the US (JAMA) Seroprevalence in Kenya (JAMA) Infections after vaccine (medRxiv) Israel data dashboard Guidelines on anticoagulation for thromboprophylaxis (Blood Adv) Baricitinib efficacy (Lancet) Long term symptoms, US adults (MMWR) Severe disease associated with long term symptoms (medRxiv) Letters read on TWiV 803 Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Guest: Shane Crotty
Become a patron of TWiV!Links for this episode ASV Vaccine Town Halls SARS-CoV-2 immune memory 8 months post-infection (Science) SARS-CoV-2 T cell epitopes (Cell Host Microbe) Letters read on TWiV 802 Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? How the cat gets its stripes
Kathy ? Kurzgesagt on Giruses (giant viruses) and beautiful APOD
Rich ? The 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle
Vincent ? Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade.
Become a patron of TWiV!Links for this episode ASV Vaccine Town Halls COVID-19 excess mortality (eLife) Tracking pandemic death toll (eLife) COVID-19 vaccines and delta variant (NEJM) Slave trade carries viruses into Mexico (eLife) Letters read on TWiV 801 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Victor Borge, Phonetic Punctuation
Brianne ? Cat TV
Rich ? Cochrane review: Ivermectin for preventing and treating COVID?19
Alan ? Cockpit video of flying into Oshkosh
Vincent ? Medical News Network Morning Medical Update
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease.
Become a patron of TWiV!Links for this episode Do not take veterinary ivermectin (FDA) Ivermectin side effects (CDC) Do not use convalescent plasma (IDSA) COVID-19 in pregnant women (JAMA) Children and COVID-19 data (AAP) Long COVID in 11-17 year olds (Res Square) Delta outbreak elementary school (MMWR) Validation of at-home antigen test (JAMA) Shedding in infected vaccinated people (medRxiv) Compared antibody responses after mRNA vaccination (JAMA) AZD7442 PROVENT phase III (AZ) Fluvoxamine trial (medRxiv) One-year outcomes hospital survivors (Lancet) Post-vaccination illness (Lancet) Letters read on TWiV 800 Timestamps by Jolene. Thanks!
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.
Become a patron of TWiV!Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptomatic COVID-19 (Nat Med) Host and vector importance for Ross River virus (eLife) Coronavirus in the U.S.: Latest Map and Case Count (NY Times) Letters read on TWiV 799 Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? A microscopic video shows the coronavirus on the rampage
Kathy ? Sabin Oral Sundays in Cuyahoga County, 1962
Rich ? The Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future
Vincent ? Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.
Become a patron of TWiV!Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins closing (Nature) WHO Committee members on TWiV 760 Origins of SARS-CoV-2 review (Cell) Comirnaty? Really Pfizer? (FDA) Why the weird name for Pfizer vaccine (Quartz) US vaccine names (CDC) More coronaviruses from rodents in China (J Viral) Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose.
Become a patron of TWiV!Links for this episode COVID-19 false dichotomies (BMC Inf Dis) Virological characteristics of infections (medRxiv) Transmission among close contacts (JAMA) Comirnaty licensed (FDA) Cost of hospitalization of unvaccinated (Health Sys Tracker) 29 times higher hospitalization among unvaccinated (MMWR) Third dose boosts antibody potency and breadth (medRxiv) J&J second dose (J&J) Letters read on TWiV 797 Timestamps by Jolene. Thanks!
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Become a patron of TWiV!Links for this episode High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv) Enhanced antibody one year after COVID-19 (Nature) Letters read on TWiV 796 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? NIF and Photon Science: fusion reaction generates 1.3 MJ
Brianne ? The PCR Song
Rich ? 1) How Boston Dynamics? Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour
Theodora ? Kevin Parry turning into random objects
Vincent ? Lex Fridman
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients.
Become a patron of TWiV!Links for this episode Age and pediatric household transmission (JAMA) Rapid antigen testing in remote communities (MMWR) Shedding of infectious virus from vaccinated individuals (medRxiv) Additional vaccine doses for immunocompromised (FDA) New vaccine mandate for New York (NYS) Vaccination suppresses variant emergence (medRxiv) mRNA vaccine effectiveness in nursing homes (MMWR) Effectiveness of mRNA vaccines against hospitalization (MMWR) mRNA vaccine sustained effectiveness against hospitalization (MMWR) No benefit of convalescent plasma for high-risk outpatients (NEJM) Letters read on TWiV 795 Timestamps by Jolene. Thanks!
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.
Become a patron of TWiV!Links for this episode Vaccine Town Halls (ASV) Arboviral illness, US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients.
Become a patron of TWiV!Links for this episode Vaccine effectiveness against transmission (Euro Surveill) Effectiveness of daily antigen tests (medRxiv) Interim guidance for fully vaccinated people (CDC) Elapsed time since BNT162b2 vaccine and reinfection (medRxiv) Reduced risk of infection after vaccination (MMWR) Therapeutic anticoagulants in critically ill patients (NEJM) 6 month outcomes in hospitalized patients (J Gen Int Med) Letters read on TWiV 793 Timestamps by Jolene. Thanks!
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission.
Guest: Jeffrey Shaman
Become a patron of TWiV!Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in India (medRxiv) Letters read on TWiV 792 Timestamps by Jolene. Thanks! Weekly Picks
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.
Become a patron of TWiV!Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction by mRNA vaccine (Nature) T cell depleted macaques recover from SARS-CoV-2 infection (mBio) Letters read on TWiV 791 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Virgin Hyperloop shows off the future
Brianne ? BioNumbers
Rich ? Advice will evolve as COVID situation changes
Alan ? Mars Perseverance-themed geocaching swag
Vincent ? Mattel?s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness.
Become a patron of TWiV!Links for this episode Outbreak in Barnstable County, MA (MMWR) Kinetics of delta variant infections (medRxiv) Prophlaxis with Regeneron mAbs (Regeneron) Subcutaneous mAbs to prevent COVID-19 (NEJM) Variant neutralization by infection or vaccine antibodies (Clin Inf Dis) Remdesivir associated with longer hospital stays (JAMA) Post-acute sequelae (Op For Inf Dis) Letters read on TWiV 790 Timestamps by Jolene. Thanks!
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.
Become a patron of TWiV!Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence (one, two, three) Disease protection by non-neutralizing antibodies (Cell) Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? Nobel Prize Games
Kathy ? Snail sensors
Rich ? In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish
Vincent ? The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans.
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system.
Guest: Kiran Thakur
Become a patron of TWiV!Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated people (NEJM) Letters read on TWiV 788 Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Simone Biles and Suni Lee
Brianne ? How Speed and Distance Dictate the Way Olympians Run
Rich ? CDC reversal on indoor masking prompts experts to ask, ?Where?s the data??
Vincent ? Paul and the Mosquitos
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers.
Become a patron of TWiV!Links for this episode Updated mask guidance (CDC) Infections in public school district employees (MMWR) 10% of positive kids need hospitalization (Houston Chronicle) Effectiveness of vaccines vs delta variant (NEJM) Antibody response after third vaccine dose (JAMA) Severe COVID-19 in kidney transplant patients (Kidney Intl) mRNA vaccine protection with or without prior infection (medRxiv) Doxycycline ineffective (Lancet) Neurological manifestations (Lancet) Infections in vaccinated health care workers (NEJM) Letters read on TWiV 787 Timestamps by Jolene. Thanks!
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19.
Become a patron of TWiV!Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letters read on TWiV 786 Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? The Science of Swimming
Kathy ? Talking to the vaccine hesitant and covidactnow.org
Rich ? The Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki)
Vincent ? Russia discards Pirs docking port to clear way for new space station module (IG post)
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.
Become a patron of TWiV!Links for this episode Letters read on TWiV 785 Timestamps by Jolene. Thanks!
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.
Become a patron of TWiV!Links for this episode Diversity of HSV2 in neonates (mSphere) Genome of HSV1 from multiple sites in one person (J Inf Dis) Rotavirus disrupts calcium homeostasis (mBio) Rotavirus protein activates calcium sensor (J Virol) Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? Inside of Mars is not like Earth
Brianne ? AlphaFold
Rich ? Tesla motors
Alan ? Diving for antique beer
Vincent ? Dolly Parton Tried. But Tennessee Is Squandering a Miracle
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.
Become a patron of TWiV!Links for this episode Long COVID in children (JAMA) Outcomes after MIS-C (Pediatrics) Guidance for school opening (Amer Acad Ped) Infection in well traced delta outbreak (medRxiv) Immune memory 8 months post-infection (Science) Low dose mRNA vaccine enhances T cells (medRxiv) Protection after infection (Lancet) Assessment of BinaxNOW (Sci Rep) Rapid POC antigen tests (Cochrane Rev) Oral azithromycin ineffective (JAMA) Post discharge symptoms in Nigeria (AJTMH) Therapeutics for low and middle income countries (AJTMH) Letters read on TWiV 783 Timestamps by Jolene. Thanks!
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.
Become a patron of TWiV!Links for this episode Immune responses after heterologous COVID-19 vaccine boost (Nat Med) Undiagnosed SARS-CoV-2 infections in US (Sci Transl Med) Broadly neutralizing sarbecovirus antibody (Nature) Timestamps by Jolene. Thanks!
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.
Become a patron of TWiV!Links for this episode SARS-CoV-2 on dogs and cats (Viruses) Maternal to neonatal transfer of SARS-CoV-2 antibodies (J Clin Investîmes) Retroviral evolution in cetaceans and their ancestors (Plos Path( Letters read on TWiV 781 Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.
Become a patron of TWiV!Links for this episode School and child care guidance (CDC) Transmission in schools (CDC) Accuracy of lateral flow diagnostics (Lancet) GBS with Ad.26.CoV2.s vaccine (FDA) Ad.26.CoV2.s interim immunogenicity (NEJM) mRNA vaccine effectiveness to prevent hospitalization (medRxiv) Bamlanivimab plus Etesevimab (NEJM) Meta-analysis of ivermectin studies (Clin Inf Dis) Letters read on TWiV 780 Timestamps by Jolene. Thanks!
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.
Become a patron of TWiV!Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleocapsid (Science) Letters read on TWiV 779 Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.
Become a patron of TWiV!Links for this episode Efficacy of portable air cleaners (MMWR) Ad26.COV2.S elicited neutralization of variants (bioRxiv) Prevention of COVID-19 with mRNA vaccines (NEJM) Ivermectin to prevent hospitalization (BMC Inf Dis) IL-6 antagonists and mortality (JAMA) Impact of vaccination on long COVID (Lancet) Letters read on TWiV 778 Timestamps by Jolene. Thanks!
Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.
Guest: Ron Fouchier
Become a patron of TWiV!Links for this episode Ron Fouchier on TWiV 177, 291, 557 Mutations driving H5N1 airborne transmission in ferrets (Cell) SARS-CoV and SARS-CoV-2 transmission among ferrets (Nat Comm) Avian influenza virus transmission among seals (Cell Host Micr) Timestamps by Jolene. Thanks! Weekly Picks
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.
Become a patron of TWiV!Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia-infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) Letters read on TWiV 776 Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.
Become a patron of TWiV!Links for this episode Worry about human behavior, not variants (NY Times) Moderna and Pfizer vaccines vs delta variant Depression among public health workers (MMWR) Correlates of protection (medRxiv) mRNA vaccine in AZ recipients (Lancet) Prior infection rescues B and T cell responses to variants (Science) Effect of vaccination on household transmission (NEJM) mRNA vaccines induce germinal responses (Nature) Novavax vaccine phase 3 results (NEJM) EUA for tocilizumab (FDA) Long COVID, next national health disaster (NEJM) Letters read on TWiV 775 Timestamps by Jolene. Thanks!
Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak.
Become a patron of TWiV!Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales from Wuhan wet markets (Sci Rep) Danielle Anderson on Wuhan Lab (Bloomberg) Timestamps by Jolene. Thanks! Weekly Picks
Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.
Guest: Laurie Garrett
Become a patron of TWiV!Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sabotaged coronavirus response (Foreign Policy) ASV Vaccine Town Hall Timestamps by Jolene. Thanks! Weekly Picks
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir.
Become a patron of TWiV!Links for this episode COVID-19 and birthday parties (JAMA) Vaccines in transplant patients (Ann Int Med) Reinfection of recovered patients (Clin Inf Dis) Azithromycin lack of efficacy (Rev Med Virol) Bacterial and fungal infections in hospitalized patients (Op For Inf Dis) mAb treatment of ambulatory patients (Op For Inf Dis) Remdesivir reduction of mortality (Gilead) Letters read on TWiV 772 Timestamps by Jolene. Thanks!
A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.
Become a patron of TWiV!Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological timescales (PNAS) Bornaviruses previously on TWiV 303, 347, 548 Novel bat SARS-CoV-2 related coronaviruses (Cell) Letters read on TWiV 771 Timestamps by Jolene. Thanks! Weekly Picks
Victor ? Vaccines: A measured response
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.
Become a patron of TWiV!Links for this episode Antiviral antibodies early in US outbreak (CID) Serologic testing of US blood donations (CID) The virus, what went wrong (PBS) MIS-C in children (JAMA) Myocarditis in competitive athletes (JAMA) ER visits for suspected suicide (MMWR) Delta variant in Scotland (Lancet) Novavax phase 3 results (Novavax) Vaccine coverage in pregnant women (MMWR) Early mAb reduces hospitalization and mortality (CID) Regen-Cov trial results (Regeneron) Guidance on postacute sequelae (CDC) Letters read on TWiV 770 Timestamps by Jolene. Thanks!
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.
Become a patron of TWiV!Links for this episode ASV Vaccine Town Hall 2:05 Novavax vaccine efficacy reported (Novavax) H3N2 glycosylation in eggs (TWiV 480) Preventing antigenically disruptive HA change in eggs (Cell Host Micr) MIS-C due to leaky gut (J Clin Invest) Letters read on TWiV 769 Timestamps by Jolene. Thanks! Weekly Picks
Brianne ? Pandemics for Babies, Germ Theory for Babies, and Vaccines for Babies
Kathy ? Playing with Time
Vincent ? A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.
Become a patron of TWiV!Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature) Nanobodies neutralize SARS-CoV-2 variants (Nature) Letters read on TWiV 768 Timestamps by Jolene. Thanks! Weekly Picks
David ? Coronavirus set to mu
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.
Become a patron of TWiV!Links for this episode COVID-19 treatment guidelines (IDSA) Hospitalization of adolescents (MMWR) Estimating dynamics from viral load (Science) Incidence according to antibody status (Lancet) Reinfections in Italy (JAMA) Need for vaccination in previously infected (medRxiv) Assessment of protection against reinfection (ACC) Antimicrobial use in hospitalized patients (Lancet) Effect of single dose ivermectin (Viruses) Aspirin in hospitalized patients (medRxiv) Letters read on TWiV 767 Timestamps by Jolene. Thanks!
David joins TWiV to relate how his near-death experience with Castleman?s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.
Guest: David Fajgenbaum
Become a patron of TWiV!Links for this episode CORONA project Center for Cytokine Storm Treatment & Laboratory Castleman Disease Collaborative Network Chasing My Cure Letters read on TWiV 766 Timestamps by Jolene. Thanks! Weekly Picks
John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.
David: Never stop questioning and always follow the data.
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.
Become a patron of TWiV!Links for this episode Updated nomenclature of SARS-CoV-2 variants (WHO) Pfizer-BioNTech vaccine effective against alpha variants (Lancet) Novavax vaccine effective against beta variants (NEJM) Moderna updated vaccine against beta and gamma variants (medRxiv) Impact of COVID-19 interventions against influenza (Nat Comm) RaTG13 spike binding to various ACE2 proteins (Cell) Timestamps by Jolene. Thanks! Weekly Picks
Dickson ? NASA?s Juno to Get a Close Look at Jupiter?s Moon Ganymede
Brianne ? Send in the Bugs. The Michelangelos Need Cleaning.
Rich ? All landers and rovers on Mars animated in video with human scale
Alan ? Weird case cluster reported in MMWR 40 years ago; update on disease
Vincent ? Virus isolates, strains, variants ? what are they?
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.
Become a patron of TWiV!Links for this episode Effects of vaccines and NPIs (JAMA) Guidance on summer camps (CDC) Antibody testing not recommended (FDA) Antigen testing at a music event (Lancet) Methotrexate and vaccine immunogenicity (Ann Rheum Dis) Colchicine phase 3 results (Lancet Resp Med) Small airway disease a post-acute sequelae (medRxiv) Letters read on TWiV 764 Timestamps by Jolene. Thanks!
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.
Become a patron of TWiV!Links for this episode Cap-snatching makes new ORFs (Cell) Cap-snatching leads to novel proteins (Cell) Letters read on TWiV 763 Timestamps by Jolene. Thanks! Weekly Picks