This Week in Virology

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.

Host: Vincent Racaniello

Guests: Volker Lohmann

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier HCV human challenge studies (Lancet Gastro Hepatol) Comparison of HCV and HAV infections (J Hepatol) HCV cell culture systems (J Med Chem)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Measles tracking (CDC) Measles in Cook County (MMWR) Gaps in measles vaccination drives viral surges (Infectious Disease Advisor) Misinformation impacts public health? Seriously? (ID Society) CDC alert for global and domestic measles cases and outbreaks (CDC) Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance) Mpox in US, 2023 (MMWR) Mpox in DRC, 2024 (reliefweb) CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society) ~5% of infected dead from mpox (CIDRAP) First cases of mpox in Republic of Congo (AP News) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Multisystem inflammatory syndrome in children 2023 (MMWR) Guidance for COVID-19 in children and adolescents (JPIDS) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Molnupiravir safety and efficacy (JMV) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) High/low oxygenation target (JAMA) How much oxygen is needed (JAMA) Orthostatic intolerance in long COVID and healthy volunteers (JMV) Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics) Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1098 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.

Host: Vincent Racaniello

Guests: Sheree Yau and Victoria Queiroz

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier 8:16 Virophage control of antarctic algal host-virus dynamics (PNAS) Timestamps by Jolene. Thanks! Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) Two groups of pithoviruses (J Virol) Educational toolkit for virology classes (J Virol)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Measles everywhere (CDC) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Estimating niresevimab effectiveness for infants (MMWR) More than 100 children died of influenza (NBS News) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Did the vaccine protect children against Long COVID (Pediatrics) Did COVID-19 vaccination impact cardiovascular diseases? (Nat Comm) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Updated respiratory infection guidelines (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID trial for autonomic nervous system dysfunction (NIH) Nirmatrelvir-ritonavir impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1096 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) Continued circulation of oropouche virus (PAHO and WHO) Herpesviruses in fur seals and sea lions (PLoS One) Sex-specific effects of SARS-CoV-2 infection (PLoS One) Drivers of 2022 Mpox virus epidemic (Cell) How AAV gene transfer works (YouTube) Humanized mouse model for AAV gene therapy (Nat Comm) Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Baden Powell ? Manha de Carneval
Angela ? Upcoming Health & Fitness podcast from MicrobeTV
Rich ? Mark Smith Photography
Alan ? OpenVertebrate (and Science article on it)
Vincent ? Veterinary apparel for the veterinary nerd

Listener Pick

Anne ? Why Reed Jobs is betting on cancer innovations

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) What to do when you are sick with a respiratory virus (CDC) Basis for respiratory virus guidance (CDC) Effectiveness of updated COVID-19 vaccines (MMWR) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Synergy or additive protection with vaccination and oral antivirals (CID) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Still talking about Ivermectin? (Journal of Infection) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Cognition and memory after COVID-19 (NEJM) Loss of IQ after SARS-CoV-2 infection (CIDRAP) Really, more evidence for long COVID and impaired cognition (NEJM) Memory assessment before and after COVID-19 (NEJM) Please complete this memory questionnaire (Community hyperbaric) Impact of long-term COVID-19 on workers in healthcare settings (PLoS One) Healthcare workers have difficulty assessing long COVID (CIDRAP) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1094 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV discusses effectiveness of this season?s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Effectiveness of flu vaccine (MMWR, Eurosurveill) Efficacy of Pfizer RSV vaccine (Pfizer) Understanding six types of vaccine technologies (Pfizer) nOPV in US? (CDC) Dengue in Peru (Peruvian State) Measles in Michigan and Indiana Marburg virus control by reservoir bats (Nat Commun) tRNA acquisition by phages (Cell) Viruses of Microbes 2024 Timestamps by Jolene. Thanks! Weekly Picks

Brianne ? The reappearance of Lake Manly
Kathy ? ?Practical Playbook for Addressing Health Misinformation?
Rich ? Making It So: A Memoir by Patrick Stewart
Jolene ? Thinking Like a Phage by Merry Youle
Vincent ? The Science of Leap Year

Listener Picks

Blog design ? Anthony Fauci will reflect on his long government career in ?On Call,? to be published in June
Peter ? Republican warns of vaccines being slipped into vegetables: ?A polio vaccine in there?

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Respiratory disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) ACIP COVID vaccination for seniors recommendations (CIDRAP) Additional vaccine doses for older adults (CDC) Evidence based advice from the ACIP (CDC) State mandates did NOT influence primary vaccination rates only boosters (PNAS) No nOPV2? (CDC) CDC Quarantine guidelines (CDC) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Spontaneous release of IFN-g in Long COVID (Science Advances) Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience) Persistent community SARS-CoV-2 RNA (Nature) Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports) Medical study questionnaire, the SHORT form (Brandeis) Long term effects of hyperbaric oxygen post COVID (Scientific Reports) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1092 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Resurgence of Lassa fever (Science) cVDPV2 in Zimbabwe (UNICEF) CWD from eating plants (CIDRAP) Measles in New Orleans (LA Dept Health) SARS-CoV-2 persistent infections (Nature) Leaky BBB for brain fog of long COVID (Nat Neurosci) Measles in Broward County FL (7 News) Failure of FL Surgeon General to support vaccination (X) Measles variant (Eurosurveillance) West Nile virus transmitted among mosquitos by excreta (bioRxiv) Mosquito life cycle (YouTube) Viroid-like colonists of human microbiomes (bioRxiv) Letters read on TWiV 1091 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Sustainable energy in America 2024 factbook
Kathy ? Life Magnified USPS stamps
Rich ? ?How plants communicate with each other when in danger? by Kasha Patel (Original Nature Communications article)
Alan ? A Sargasso Sea of Space card game.
Vincent ? Tell Me When It?s Over by Paul Offit

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week?s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Respiratory disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Abrysvo vaccine stats (Axios) RSV vaccination dashboard (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Who is more accurate the clinician or the self for BinaxNow rapid testing (ASM Spectrum) Annual N95 fitting (Infection Control and Hospital Epidemiology) How vaccination impacts long COVID prevalence (Annals of Epidemiology) CDC Quarantine guidelines (CDC) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID in adults (MMWR) Estimating and predicting fatiguing illness after SARS-CoV-2 infection (EIS) Long term risks of respiratory disease following SARS-CoV-2 infection (eClinical Medicine) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1080 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Fatal case of Alaskapox (AK Beacon) MERS in Kenya (Emerg Inf Dis) Diagnostic tests for Nipah and Lassa (CEPI) Measles in Arizona and Minnesota HCV-derived circular RNAs (PNAS) Resident memory CD8 T cells prevent respiratory virus transmission (Nature) Letters read on TWiV 1089 1:24:33 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Visualizing Science: Illustration and Beyond
Brianne ? Vaccination from the Misinformation Virus and Invisible Corps
Alan ? Preventing needlephobia in kids
Vincent ? Two new Djs I discovered Rosana Nun and Sunset Cartel

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK?s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Nirsevimab immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.) Arexvy given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Can antibodies be redirected from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat) Can influenza infection lead to cardiovascular events (JID) Risk of death after chikungunya infection and disease (Lancet) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC)  Variant hospital admissions (CDC) Alternative intervals between vaccine doses (Nat Comm)  Early mortality after first vaccination dose (CID) CDC Quarantine guidelines (CDC) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED)  How to pay for Paxlovid (PAXCESS)  Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Burnout compassion fatigue Long COVID (OFID)  Scoring PASC (JAMA)  What is your definition of the Long COVID (WHO) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1088 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open) Onradivir new influenza antiviral (Lancet) Oropouche fever in Brazil (PAHO) Maryland and Ohio measles Repealing school vaccination exemptions (JAMA New Open) Increases risk of FMDV entry into Europe (pig333) Severe primary and secondary dengue (Nat Med) Mitigation of measles immune amnesia and exacerbated disease (Nat Comm) Letters read on TWiV 1087 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? For Your Processing Pleasure: The Sharpest Pictures of Jupiter?s Volcanic Moon Io in a Generation
Angela ? Whale Scientists
Rich ? Benefit-risk assessment of vaccines; The Brighton collaboration standardized module for vaccine benefit-risk assessment; Vaccine adverse events: causal or coincidental?; Austin area Singing Valentines
Vincent ? International Day of Women and Girls in Science, 11 February

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one?s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Do you want a job in healthcare? (JAMA) Why people don?t tell the truth about infectious diseases (Psychological Science) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Is susceptibility and severity of COVID-19 inheritabile (Nat Comm) Neonates of vaccinated mothers (JAMA) How is the monovalent XBB.1.5 vaccine effectiveness against symptomatic infection  Sept 2023-Jan 2024 (MMWR) Second dose in the opposite arm improves antibody response (JCI) Virus specific immune repsonses following contralateral or ipsilateral immunication (eBioMedicine) CDC Quarantine guidelines (CDC) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) How COVID-19 affected your sleep (Frontiers in Public Health) Health and economic burden of COVID-19 after illness (BMC Medicine) Predicting recovery from fatigue and cognitive deficits after COVID-19 (eClinical Medicine) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1086 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Pig virus imperils food security in Borneo (Science) Measles outbreaks in UK and Europe (Nature) Fatal Nipah virus infections in Bangladesh (CIDRAP) Yellow fever outbreak in Sudan (Crisis24) COVID-19 influenced by type of immunodeficiency (Sci Transl Med) Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe) Letters read on TWiV 1085 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? JWST details of 19 spiral galactic centers
Rich ? Great White Shark Attack And Breach
Vincent ? Black History Month and Lost Photographs of Black America

Listener Picks

Louise ? The Mystery Of The Village That Beat The Black Death
Pierre ? Three things airlines don?t want you to know
Brandon ? Professor Dave explains

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Do you want a job in healthcare? (JAMA) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Efficacy and safety of RSV vaccine after 2 seasons (CID) High vs moderate dose of quadrivalent influenza vaccine (CMI) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) WHO COVID guidance (WHO) Thoughts on COVID guidance (CIDRAP) Update on how to prevent pathogen transmission in healthcare settings (CDC) Underuse of antiviral drugs against COVID-19 (MMWR) Revisiting tissue culture cells persistently infected following antiviral therapy (bioRxiv) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Changes in inflammatory markers and death correlation when in ICU (Cytokine) Long COVID & cognitive slowing? (eClinicalMedicine)   Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1084 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Jay Nelson obituary Measles outbreak in Europe and Central Asia (UNICEF) Closing the toilet lid doesn?t reduce virus aerosols (Am J Inf Control) NASA?s ingenuity helicopter mission ends (NASA) HPV vaccine prevents invasive cervical cancer (J NCI) Designing AAV vectors with machine learning (Sci Adv) Letters read on TWiV 1083 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Asian girl building a life building a fence to protect a bamboo house
Rich ? Gator Country: Deception, Danger, and Alligators in the Everglades by Rebecca Renner
Alan ? Strange Bedfellows, by Ina Park
Vincent ? Star and Sphere kit ? try the main page too

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Articles and graphs cited in TWIV CU 1080 Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Transmission in healthcare setting (CID) COBREVAX EUA (Texas Children?s Hospital) Quarantine/isolation guidelines (CDC) Simnotrelvir for mild to moderate disease in adults (NEJM) Are your tissue culture cells persistently infected following antiviral therapy (bioRxiv) Structural biology of antivirals for SARS-CoV-2 (Signal Tranduction and Targeted Therapy) To rebound or to not rebound (MMWR) Know your COVID-19 tools (ESMED) How to pay for Paxlovid (PAXCESS) Remdesivir for immunocompromised during variant waves (CID) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Patients, experts, Congress?..long COVID oh my! (CIDRAP) Does paxlovid prevent long COVID? (CIDRAP) Persistent complement with thromboinflammation in long COVID (Science) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1082 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Midwife gave children pellets instead of vaccines (NY Times) Vaccine derived poliovirus circulation in Indonesia (WHO) 9th case of measles in Philadelphia (City of Philadelphia) Measles exposure warning northern Virginia (Virginia DOH) China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ) Wisconsin bill to restrict gain of function experiments (Science) Virus infection of insects causes long wings (PNAS) Reverse zoonoses of influenza H1N1 virus in swine (PLoS Path) Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Concerto for Horn and Hardart, P. Schickele
Angela ? ChatGPT4
Brianne ? How mRNA Vaccine Works, Why We Need Two Doses of mRNA Vaccine
Rich ? Evolutionary basis for the human diet: consequences for human health by P. Andrews, R.J. Johnson
Vincent ? Virology Lectures 2024

Listener Picks

Geoff and Anonymous ? Dickson Despommier wants our cities to be like forests

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the role of immune aberrations in long COVID and how vaccination may protect against developing long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend(CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Remember when COVID was bad? (Wired) Children and adolescents hospitalized with SARI (Pediatrics) COVID-19 vaccines are effective for adolescents (Pediatrics) Vaccine effectiveness against long COVID in children (Pediatrics) Infant and toddler socioemotional development in the pandemic (JAMA) Quarantine/isolation guidelines (CDC) Should I take Paxlovid? (NY Times) What is this about Paxlovid rebound? (CDC) Rebound is NOT the early inflammatory phase (ESMED) How to pay for Paxlovid (PAXCESS) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) T cell dysregulation inflammation and uncoordinated adaptive immune response, Long COVID oh my (Nat Imm) Vaccine effectiveness against long COVID (CIDRAP) Prevention of long COVID by vaccines (Antimicrobial-stewardship and healthcare) Sex and gender relationship with long COVID (Eurosurveillance) Are all vaccines equal in preventing Long COVID? (Lancet) Vaccine naïve individuals, Long COVID and vaccination (medRxiv) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1080 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, dissociation of antiviral treatment from infection rebound, and long COVID, deaths due to administration of hydroxychloroquine, muscle abnormalities and extreme fatigue in individuals with long COVID-19 and how the economics of where you live make long COVID-19 more severe.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

A national measles campaign (CDC) A nation of measles (CDC) The measles unvaccinated in NY (CNN) Philadelphia?s measles story (Phila gov) January?s measles outbreak (CNN) Prequalify of nOPV2 by WHO (GPEI) Did you prequalify for the novel poliovirus vaccine (CIDRAP) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend(CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Death rate and C-reactive protein SNPs and COVID-19 (Scientific Reports) Variant tracker (CDC) Tracking variant hospitalizations (CDC) Early vaccination against XBB.1.5 hospitalization (Eurosurveillance) Vaccination dashboard (Netherlands) Quarantine/isolation guidelines (CDC) Antiviral gap among the non-hospitalized high risk adults (CID) Oral antivirals prevent hospitalization (medRxiv) Rebound with and without oral antivirals (MMWR) Randomized rebound trials (MMWR) Know your COVID-19 tools (ESMED) The PASC-paxlovid relationship (JAMA) Molnupiravir safety and efficacy (JMV) Convalescent plasma remmendation for immunocompromised (IDSociety) Fluvoxamine for COVID-19 outpatient (RMV) Death by hydroxychloroquine (Biomedicine & Pharmacotherapy) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Doxycycline for prevention of progression of COVID-19 (PLoS One) Muscle abnormalities in long COVID (Nat Comm) Discovery of persistent fatigue in long COVID-19 (Amsterdam Univ Med Crr) IMPACC study post-acute sequelae results (Nat Comm) Double course of long COVID in low income countries (Nat) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1078 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Global dengue cases rise markedly (WHO) Measles outbreak in Philadelphia (Phil Health Dept) Viruses and organomineralization of travertine (Sci Rep) Neutralizing antibodies and clearance of HCV infection (Immunity) Letters read on TWiV 1079 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Global climate highlights 2023 and 7 new songs you should hear
Brianne ? Stuff you should know episodes: METI and SETI
Kathy ? Oppenheimer ?Science, Mission, Legacy? documentaries from Los Alamos Lab One Two Three and Los Alamos National Laboratory Summer 2023 National Security Science: The Oppenheimer Issue
Rich ? The Wager: A Tale of Shipwreck, Mutiny and Murder by David Grann
Alan ? Less is Morse, an educational game
Vincent ? Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines

Listener Picks

Sonrisa ? Microorganisms in Perspective
Anonymous ? Wow! Human Cells Vibrate With Resonant Frequency and It?s Technically Audible

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Vincent travels to McGill University in Montreal, Canada to join Angela for a discussion of the careers and the research of two faculty members, Corinne Maurice and Jesse Shapiro, and their PhD trainees Anshul Sinha and Sana Naderi.

Hosts: Vincent Racaniello and Angela Mingarelli

Guests: Corinne Maurice, Jesse Shapiro, Anshul Sinha and Sana Naderi

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Phage and colitis (Microbiome) Origins and evolution of Lassa virus (Cell) Phage replication in human gut microbiota (iScience) Phages in infant gut (ISME J) Early SARS-CoV-2 transmissions in Quebec (Genome Med) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects of SARS-CoV-2 infection and virus transmission in Italy between early 2020 and 2022, the guidelines to improve home ventilation, the safety and efficacy of the oral anti-viral molnupiravir and the use of convalescent plasma as a long term treatment as well as treatment specifically for the immune compromised, the ineffectiveness of antibiotics for treating COVID-19, the association of olfactory dysfunction and the administration of corticosteroids and the safety of the RSV vaccines licensed last year.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Articles and graphs cited in TWIV CU 1076 Global mpox circulation (WHO) Mpox in the Americas and Europe (CIDRAP) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Vaccine-Eligible Children Under-5 Years (PIDJ) Pre-school cohort vaccination rate (CIDRAP) Perinatal transmission and neonatal outcomes (IJID) Adverse maternal and neonatal effect (dgalerts) Ventilation home improvements (CDC) Quarantine/isolation guidelines (CDC) Molnupiravir safety and efficacy (JMV) Convalescent plasma remmendation for immunocompromised (IDSociety) Corticosteroids in SARS-CoV-2 Anticoagulation guidelines (hematology.org) Corticosteroids induced olfactory dysfunction (PLoS One) Convalescent Plasma Therapy: Long Term Implications (OFID) Preventing RSV infection by vaccination (MMWR) Antivirals and chronic kidney disease (CID) Early administraton of molnupiravir versus ritonavir-boosted nirmatrelvir (Lancet Infectious Diseases) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1076 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek?s disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Ancient chickens and Marek?s disease virus (Science) Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) Letters read on TWiV 1074 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Addictive Mandelbrot video and Gore slams COP28 summit
Angela ? 10 top-trending health questions you had for Dr. Google in 2023
Brianne ? Tomato lost in space has been found
Kathy ? Earthquakes of the 20th Century
Vincent ? Animator Chris Georgenes especially Tricycle animation study

Listener Picks

Jason ? Spot-on, quick booster explainer and ?Inverse? vaccine Slashdot?s summary. the full article, primary research article
Meika ? Iceland earthquake site

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the outcomes of SARS-CoV-2, influenza and respiratory syncytial virus infection in pediatric communities under the age of 18 years, the treatment of infants with the human monoclonal anti-respiratory syncytial virus antibody to prevent hospitalizations, most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, how the SARS-CoV-2/COVID-19 pandemic affected school attendance and child healthcare, how exposure length influenced transmission of SARS-CoV-2, how the durability of the anti-SARS-CoV-2 antibody response to protect against virus re-infection, if administration of oral antiviral therapy affected viral rebound in either the unvaccinated or vaccinated populations, as well as a reminder of the ineffectiveness of antibiotics for treating COVID-19 and the effect of vaccination on post-COVID conditions in children between 5-17 years old.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Pediatric outcomes SARS-CoV-2, flu, RSV (JAMA Peds.) SARS-CoV-2 vs Flu  (Wired) Anti-RSV antibody treatment for infants (NEJM) Respiratory  disease surveillance (CDC) RSV surveillance  (CDC) RSV national trend (CDC) Influenza/flu surveillance  (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) COVID-19 school attendance (JPEIDS) COVID-19 pandemic effects children health care (JPEIDS) Digitally measuring transmission (Nat) Antibody titers and re-infection (CMI) Oral antiviral and SARS-CoV-2 rebound (MMWR) Rebound after antiviral controlled trial (MMWR) Vaccination and antiviral therapy (OFID) Antivirals and hospitalization (JMV) Antivirals molnupiravir (JMV) Convalescent plasma and the immunocompromised guidelines (IDSOciety) Steroid and the cytokine storm (OFID) Anticoagulation guidelines (hematology.org) Unnecessary antibiotics (NEJM) Vaccination and long COVID (OFID) RSV vaccination (MMWR) Antivirals and chronic kidney disease (CID) Early administraton of molnupiravir versus ritonavir-boosted nirmatrelvir (Lancet) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1074 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Brett Lindenbach passes (Yale Medicine) Virome of small mammals (Cell) Epstein-Barr virus nanoparticle vaccine (Cell Host Micr) Letters read on TWiV 1073 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music
Kathy ? Two APODS  Winter solstice, 183 Days in the Sun and the Same color illusion
Vincent ? The American Academy of Microbiology discusses gain-of-function research of concern (GOFROC) and enhanced potential pandemic pathogens (ePPP)

Listener Picks

Gregory ? Climate Change ? A revised prediction ? Steven Chu
John ? Detergent packs are kinda wishy-washy (Technology Connections)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update Dr. Griffin discusses the annual economic burden of respiratory syncytial virus in adults in the US, recombinant or standard-dose influenza vaccine in adults under 65 years of age, maternal vaccine effectiveness against influenza-associated hospitalizations and emergency department visits in iInfants, influenza positive tests reported to CDC by US clinical laboratories, update on COVID-19, risk of severe maternal morbidity associated with SARS-CoV-2 infection during pregnancy, COVID-19 rapid antigen tests with self-collected vs health care worker?collected nasal and throat swab specimens, optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation, long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study, and risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode RSV economic burden, US (J Inf Dis) Recombinant or standard dose influenza vaccine (NEJM) Maternal vaccine effectiveness against influenza in Infants (JAMA Ped) Weekly influenza surveillance report (MMWR) COVID data tracker (hospital admissions, national trend) Risk of severe maternal morbidity associated with SARS-CoV-2 infection (J Inf Dis) COVID-19 rapid antigen tests with nasal and throat swab specimens (JAMA Net Open) Optimal timing of nirmatrelvir/ritonavir (Nat Comm) Long-term outcomes following hospital admission for COVID-19 vs influenza (Lancet) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1072 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Vincent visits the Max Planck Institute for Medical Research in Heidelberg, Germany to speak with Matthias Fischer about his career and his research on giant viruses, virophages, and their protist hosts.

Host: Vincent Racaniello

Guest: Matthias Fischer

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) C. roenbergensis giant virus (PNAS) Virophage at origin of large DNA transposons (Science) Host genome integration and giant virus-induced reactivation of virophage mavirus (Nature) Invasion of protist genomes by DNA viruses (PNAS) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses monkeypox and chickenpox co-infection in southern Nigeria, vaccine effectiveness against influenza A, SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk, COVID-19 rapid antigen tests with self-collected vs health care worker?collected nasal and throat swab specimens, four methods for monitoring SARS-CoV-2 and Influenza A virus activity in schools, efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19, a synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong, consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications, and risk of new-onset long COVID following reinfection with SARS-CoV-2.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Monkeypox and chickenpox co-infection in southern Nigeria (JID) Vaccine effectiveness against influenza A (CID) SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk (JOP) COVID-19 rapid antigen tests with self-collected vs health care worker?collected nasal and throat swab specimens (JAMA) Four methods for monitoring SARS-CoV-2 and influenza A virus activity in schools (JAMA) Efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19 (EJMR) A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (The Lancet) Consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications (JID) Risk of new-onset long COVID following reinfection with SARS-CoV-2 (OFID) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control.

Hosts: Vincent Racaniello and Heli Harvala

Guest: Eeva Broberg

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) European Centre for Disease Prevention and Control Emerging echovirus 30 in Europe (Emerg Inf Dis) RSV surveillance (Eur Resp J) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Developmental impairment in children exposed during pregnancy to maternal SARS-COV2 (IJID) Vagus nerve dysfunction in the post-COVID-19 condition (CMI) Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in those with rheumatic diseases (STM) Incidence and burden of long COVID in Africa (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

On this all-bacteriophage episode, TWiV explains the ?vampire phage?, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Gerd Sutter passes (LMU) Avian influenza A (H5N1) Cambodia (WHO) CWD expands in Montana (CIDRAP) National Wastewater Surveillance System (CDC) Vampire phage paper (ISME J) UMBC phage hunters (UBMC) Vampire viruses prey on other viruses (Conversation) Phage internalized by mammalian cells (PLoS Biol) Phage uptake by mammalian cells (iScience) Phage-mammalian cell interactions (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Biden skips climate summit (NY Times)
Rich ? Lilium electric VTOL jet
Alan ? The Far Land, by Brandon Presser
Jolene ? Bacteriophage T4 infection watercolor painting by David Goodsell
Vincent ? Using narratives and storytelling to communicate science with nonexpert audiences

Listener Picks

Darach ? It depends t-shirt

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing impact of COVID-19 on infant health, COVID-19 vaccine effectiveness against post- COVID -19 condition among 589722 individuals in Sweden, repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting, protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes among community-dwelling adults, the Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA vaccines, T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19, oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China, and how COVID-19 convalescent plasma therapy decreases inflammatory cytokines, therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial.

Click arrow to play

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Microbiologist who was harassed during COVID pandemic sues university (Nature) Use of inactivated poliovirus vaccine for outbreak response (The Lancet) Safety and immunogenicity of bivalent RSVpreF vaccine coadministered with Influenza vaccine (CID) Coffee as a dietary strategy to prevent SARS-CoV-2 infection (BMC) Enrollment of pediatric patients in COVID-19 interventional trials (JAMA) Vaccination, immunity, and the changing impact of COVID-19 on infant health (PNAS) COVID-19 vaccine effectiveness against post- COVID -19 condition (BMJ) Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting (Nature) Protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes (CID) Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA (JID) T-cell responses to SARS-CoV-2 infection and vaccination reduce risk of severe COVID-19 (STM) Oral VV116 vs placebo in patients with mild-to-moderate COVID-19 in China (The Lancet) COVID-19 convalescent plasma therapy decreases inflammatory cytokines (MS) Therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial (Chest) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV on TWiV 1066 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier House approves ban on gain-of-function research (Science) Virology under the microscope (J Virol) CWD detected in another Tennessee county (CIDRAP) Polio eradication: Do no harm (Science) nOPV2 causes polio (MMWR) How is nOPV2 doing? (Polioeradication.org) Feline infectious peritonitis caused by recombinant coronavirus (bioRxiv) New feline coronavirus kills thousands of cats (Science) Feline coronavirus with Gary Whittaker (TWiV 963) Letters read on TWiV 1065 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Climate Action and How to find joy in climate action
Brianne ? A Virus that Generates Electricity
Kathy ? Intolerable Genius: Berkeley?s most controversial Nobel laureate
Rich ? Programmed DNA Elimination (PDE): Quanta; Current Biology
Alan ? KBDfans mechanical keyboard kits
Vincent ? The Covid Vaccine Windfall Turns for Pfizer and Moderna

Listener Picks

Meika ? Iceland Eruption or not?

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Progress toward measles elimination (CDC) Risk of severe COVID-19 despite vaccination in patients using immune-suppressive drugs (TID) Symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to untreated individuals (CID) Late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial (JID) Higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19 (JAMA) Recombinant C1 inhibitor in the prevention of severe COVID-19 (FII) Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with SARS-CoV-2 disease course (BMC) Contribute to our MicrobeTV fundraiser at PWB 37:55 Letters read on TWiV on TWiV 1062 38:16 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases.

Host: Vincent Racaniello

Guest: Kevin Messacar

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Emergence of EV-D68 (Microbio Spectr) 2014 outbreak of EV-D68 (J Med Virol) EV-D68 shedding in households (Emerg Inf Dis) EV-A71 outbreak in Colorado (Lancet Inf Dis)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir?ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir?ritonavir therapy.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Coverage with selected vaccines and exemption from school vaccine requirements among (CDC) Seasonality of endemic COVID-19 (Virology) mRNA SARS-CoV-2 vaccination before vs during pregnancy and Omicron infection among infants (JAMA) Extracting symptoms from responses using ChatGPT among COVID-19 cases (CMI) SARS-CoV-2 virologic rebound with nirmatrelvir?ritonavir therapy (AIM) Optimization of antiviral therapy in immunocompromised COVID-19 patients (ClinicalTrials) A study to learn about nirmatrelvir/ritonavir in people with COVID-19 and a compromised immune system (ClinicalTrials) Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection (EJP) Effect of neutralizing monoclonal antibody treatment on virologic and immunologic biomarkers in patients with COVID-19 (JID) SARS-CoV-2 virologic rebound with nirmatrelvir?ritonavir therapy (AIM) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV on TWiV 1062 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Seasonality of endemic COVID-19 (mBio) Diversity of non-vaccine targeted HPVs (Cell Host Microbe) Wart?s up doc? (TWiV 126) Letters read on TWiV 1061 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? 2023 expected to be hottest year on record after warmest October ever
Kathy ? You can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably)
Alan ? Landmark case to get sanitation declared a civil right
Vincent ? SciComm Studios

Listener Picks

Charmaine ? Petition fo National Science Appreciation Day
Peter ? Let?s eradicate polio this winter

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-? release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19?induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Stress in America 2023 (APA) CDC expands testing of international air traveler samples to include flu RSV, and other respiratory viruses (CDC) Missed opportunities for preventing congenital syphilis (CDC) Intrinsic and effective severity of COVID-19 case infected with BA.2 variant (JID) Masks during pandemics caused by respiratory pathogens (JAMA) Behavioral factors and SARS-CoV-2 transmission within a household cohort (Nature) Convalescent plasma for Covid-19?induced ARDS in mechanically ventilated patients (NEJM) Olfactory and gustatory function 3 years after mild COVID-19 (JAMA) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV on TWiV 1060 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Monoclonal antibody neutralizes all three poliovirus serotypes (Nat Comm) Blocking Ebolavirus intercellular spread (Cell Rep) Letters read on TWiV 1059 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? Climate Science
Angela ? Spider Ballooning (Wikipedia)
Kathy ? Richard Harris Art Collection
Rich ? ?The Murderbot Diaries? by Martha Wells
Alan ? Old Gods of Appalachia
Vincent ? Poetry Foundation

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses health worker?perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir?ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Routine vaccination coverage (CDC) Outbreak of invasive Group A Streptococcus in children (PIDS) Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 (Nature) Outcomes of SARS-CoV-2 omicron variant infections compared with seasonal influenza and RSV infections in adults (CID) Remdesivir is associated with reduced mortality in COVID-19 patients requiring oxygen (OFID) Effectiveness of nirmatrelvir/ritonavir against the development of Post?COVID-19 conditions among U.S. veterans (AIM) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1058 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells.

Host: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Klaus Früh

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) HCMV-based attenuated vaccine platform (Sci Rep) HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol) RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses health worker?perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir?ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Health worker?perceived working conditions and symptoms of poor mental health (CDC) Neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet) Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy (JAMA) Duration of SARS-CoV-2 culturable virus shedding in children (JAMA) Prescribing outcomes in outpatients treated with PAXLOVID for COVID-19 (PLOS ONE) Nirmatrelvir and molnupiravir and post?COVID-19 condition in older patients (JAMA) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Intravenous vitamin C for patients hospitalized with COVID-19 (JAMA) Association between Guillain-Barré syndrome and COVID-19 infection and vaccination (NH) SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration (JIM) Transplanting candidates with COVID-19 (TID) Favorable experience of transplant strategy including liver grafts from COVID-19 donors (TID) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1056 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis.

Host: Vincent Racaniello

Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Lab worker contamination with SARS-CoV-2 plasmid DNA (J Clin Micro) Fractional dose poliovirus vaccine (Vaccine) No SARS-CoV-2 RNA in Vermont wildlife (Sci Rep) Predicting SARS-CoV-2 infectivity from RT-PCR (EMBO Mol Med) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged

From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals.

Host: Vincent Racaniello

Guests: Ron Fouchier, Rafael Medina, and Louise Moncla

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Centers for Influenza Research and Response Network Transatlantic spread of avian H5N1 influenza virus (Sci Rep) In-host diversity of influenza H5N1 virus (PLoS Path) Influenza H5N1 virus and mass mortality in sea lions (Vet Q.) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ?60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvir in patients with symptomatic COVID-19 (The Lancet) Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA) Antibiotic use among hospitalized patients with COVID-19 (OFID) One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19 Assessment of the available therapeutic approaches for severe COVID-19 (Nature) Optimal duration of systemic Corticosteroids in COVID-19 treatment (OFID) Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and in patients with long-COVID syndrome (Nature) Local budesonide therapy in the management of persistent hyposmia in suspected COVID-19 patients (JID) Safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with Kidney disease and COVID-19 Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1052 Dr. Griffin?s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 2023 Nobel Prize Physiology or Medicine (Nobelprize.org) Evading a toll on the road to mRNA vaccines (TWiV 860) Katalin Karikó?s overlooked work (Wired) Accelerated mutation of SARS-CoV-2 in deer (Nat Comm) Letters read on TWiV 1051 Timestamps by Jolene. Thanks! Weekly Picks

Dickson ? The New City. How to Build Our Sustainable Urban Future
Angela ? 2023 Nobel Peace Prize
Alan ? The Ruin of All Witches, by Malcolm Gaskill
Vincent ? France kicks off bird flu vaccination despite trade backlash risk

Listener Pick

Charles ? David Brooks and the $78 airport meal the internet is talking about
John ? Periodic Table of the Elements: Origins of the Elements
AZ ? Bronze statue of laboratory mouse knitting DNA in Russia

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19?associated hospitalizations in infants aged