F.A.Z. Wissen

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Die Links zu dieser Podcast-Folge:

• Manuel Häußler et al, Nature, 2021, "Closed-loop recycling of polyethylene-like materials"
• Preisträger-Seite zum Deutschen Studienpreis 2022, Kategorie Natur- und Technikwissenschaften
• Das neue Leipziger "Center for the Transformation of Chemistry"
• Das SPRIN-D Challenge Programm: "Circular Biomanufacturing"

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Die Links zu dieser Podcastfolge:

- Dissertation v. Dr. Laura Wendorff “Gesamtdeutsche Potenzialanalyse hinsichtlich Selbstversorgung im Stromsektor für Kommunen im ländlichen Raum“

• PM Kraftwerksstrategie der Ampel

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Links zu diesem Podcast:

Instituts-Webseite von Prof. Sina Leipold

Veröffentlichungen und Zitationen von S. Leipold

Planetarische Gemeinschaftsgüter, PNAS-Paper von Johan Rockström et al, 2024

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Die Links zu dieser Podcastfolge:

• S. Anderl, F.A.Z. v. 13.März 2020, "Die Seltsame Ähnlichkeit von Mond und Erde"

• Q. Yuan et al, Nature, 1. Nov. 2023, "Moon-forming impactor as a source of Earth’s basal mantle anomalies"

• C. Fonseca, …, L. Hurst: „People with more extreme attitudes towards science have self-confidencein their understanding of science even if this is not justified“, PLOS Biology, 24.1.2023

• Kevin Aslett et al, Nature v. 20. Dez. 2023, "Online searches to evaluate misinformation can increase its perceived veracity"

Die Paper und Links zu diesem Podcast:

• W. Percival et al.: "The Euclid Mission", 21.10.2019

• The Royal Swedish Academy of Sciences: "Scientifc Background on the Nobel Prize in Physics 2011 - THE aCCELERATING UNIVERSE", 2011

• K.T. Inoue et al.: "ALMA Measurement of 10 kpc-scale Lensing Power Spectra toward the Lensed Quasar MG J0414+0534", Astrophysical Journal, September 7, 2023

Y. Bengio et al. (2023): "Managing AI risks in an era of rapid progress", arXiv 2310.17688, 26.10.23

D. Chalmers (2023): "Could a large language model be conscious?", arXiv 2303.07103, 29.4.23

"The Bletchley Declaration by Countries Attending the AI Safety Summit", 1-2 November 2023

The White House: "Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence", 30.10.23

Offener Brief von LuCun et al. als Reaktion auf Bidens Executive Order

Die diskutierten Veröffentlichungen:

Nils Bochow et al.: "Overshooting the critical threshold for the Greenland ice sheet", Nature, 19.10.2023

Kaitlin A. Naughten, Paul R. Holland, Jan De Rydt: "Unavoidable future increase in West Antarctiv ice-shelf melting over the twenty-first century", Nature Climate Change, 23.10.2023

Zusammenfassung Kipppunkte des IPCC:

IPCC: "Climate Change 2021: The Physical Science Basis". Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press, S. 106

Die Links zu dieser Podcast-Folge:

• Michael Wong et al, PNAS, 2023, "On the roles of function and selection in evolving systems"

• Jan-Michael Rost, Klaus Richter. Fischer Taschenbücher Bd.15550, 2002, "Komplexe Systeme"

Die Paper und Links zu dieser Podcastfolge:

• Nobelpreise 2023: Die Homepage der Nobel-Organisation

• Regenwurm-Publikation: Steven Fonte et al, Nature Communications, 2023, "Earthworms contribute significantly to global food production" (Open access)

CO2-Bilanz, El Niño und tropische Regenwälder:

• A. Benett et al. (2023): "Sensitivity of South American tropical forests to an extreme climate anomaly", Nature Climate Change, 4.9.2023

Solar Geoengineering:

• A. Lockley, I. Mundra, P.T. Smith (2023). "Legitimacy and justifiability of non-state geoengineering", Futures, September 2023
• OSTP. (2023). "Congressionally Mandated Research Plan and an Initial Research Governance Framework Related to Solar Radiation Modification". Office of Science and Technology Policy, Washington, DC, USA., Juni 2023
• Report der Climate Overshoot Commission (2023) "Reducing the Risks of Climate Overshoot", September 2023
• National Academies of Sciences, Engineering, and Medicine (2021): "Reflecting Sunlight - Recommendations for Solar Geoengineering Research and Research Governance"

Publikation zur Auswahl des goldenen Nagels:

• C. Waters, S. Turner, J. Zalasiewicz, M. Head (2023): "Candidate sites and other reference sections for the Global boundary Stratotype Section and Point of the Anthropocene series", The Anthropocene Review

Informationen zum Crawford-See

Die Paper zu dieser Podcast-Folge:

• Aufzählungs-TextEuropean Pulsar Timing Array (EPTA): Datenpaket und Paper in "Astronomy and Astrophysics", 2023

• Kai Kornhuber et al, Nature Communications, 2023, "Risks of synchronized low yields are underestimated in climate and crop model projections"

Studien der Folge:

Lichtverschmutzung:

• Keith Smith et al. (2023): "Losing the darkness", Science

• Miroslav Kocifaj et al. (2023): "Measuring and monitoring light pollution: Current approaches and challenges", Science

• Annika K. Jägerbrand, Kamiel Spoelstra (2023): "Effects of anthropogenic light on species and ecosystems", Science

• K. M. Zielinska-Dabkowska et al. (2023): "Reducing nighttime light exposure in the urban environment to benefit human health and society", Science

• Antonia M. Varela Perez (2023): "The increasing effects of light pollution on professional and amateur astronomy", Science

Sittenverfall:

• Adam Mastroianni und Adam Gilbert (2023): "The illusion of moral decline", Nature

Die Paper zu dieser Podcast-Folge:

• Timothy Lenton et al, Nature Sustainability, 2023, "Quantifying the human cost of global warming"

• Johan Rockström et al, 2023, Nature, "Safe and just Earth system boundaries"

Weitere wissenschaftliche Links zum Thema:

• "Earth Commission"
• "Future Earth"

Überblick über die Streitfrage:

• Sibylle Anderl (2019): "Messfehler oder die Auflösung der Krise?"

Artikel zur Methode:

• T. Treu, P. Marshall (2016): "Time Delay Cosmography", The Astronomy And Astrophysics Review

Artikel zur neuen Messung:

• P. Kelly et al. (2023): "Constraints on the Hubble constant from Supernova Refsdal’s reappearance", Science

Die Paper und Links zu dieser Podcast-Folge:

• Lucina Halupka et al, PNAS, 2023, "The effect of climate change on avian offspring production: A global meta-analysis"

• Marketa Zimowa et al, PNAS, 2023, "Body size predicts the rate of contemporary morphological change in birds"

• Peter Narins, Acoustical Society of Amerika, "Warmer climate could cause Puerto Rico’s frogs to croak"

Julian Michael et al. “What do NLP Researchers believe? Results of the NLP Community metasurvey”, arXiv, 8/2022

Samuel Bowman: “Eight Things to Know about Large Language Models”, arXiv, 4/2023

Murray Shanahan: "Talking about Large Language Models", arXiv, 2/2023

Emily Bender & Alexander Koller: “Climbing towards NLU: On Meaning, Form, and Understanding in the Age of data”, Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics, 7/2020

Die Paper zu dieser Podcast-Folge:

• Vikki Thompson et al, Nature Communications, 2023, "Climate change: Identifying regions most at-risk of high-impact heatwaves"

• World Weather Attribution, 2023, "Human-induced climate change increased drought severity in Horn of Africa"

• Aichar Zekar et al, Urban Climate, 2023, "Urban form features determine spatio-temporal variation of ambient temperature: A comparative study of three European cities"

• Keer Zhang et al, Nature, 2023, "Increased heat risk in wet climate induced by urban humid heat"

Kareem El-Badry et al. (2022): „A Sun-like star orbiting a black hole”, MNRAS, 2.11.2022

Kareem El-Badry et al. (2023): “A red giant orbiting a black hole”, MNRAS, 30.3.2023

JW Nightingale et al. (2023): „Abell 1201: detection of an ultramassive black hole in a strong gravitational lens”, MNRAS, 29.3.23

Rebecca Larson et al. (2023): „A CEERS Discovery of an Accreting Supermassive Black Hole 570 Myr after the Big Bang: Identifying a Progenitor of Massive z>6”, arXiv, submitted to ApJ

Lia Medeiros et al. (2023): “The image of the M87 Blck Hole Reconstructed with Primo”, ApJ Letters

Die Links zu dieser Folge:

• M. England et al, Nature, 2023, "Abyssal ocean overturning slowdown and warming driven by Antarctic meltwater"

• C. Batchelor et al, Nature, 2023, "Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day"

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Fragen und Anregungen bitte an: [email protected]

Die Paper zu unserer heutigen Podcast-Folge:

• Mathew Roddell et al, Nature Water, 2023, “Changing intensity of hydroclimatic extreme events revealed by GRACE and GRACE-FO“
• WMO, Nov. 2022, „State of the World Water Resources“
• Melissa Rohde et al, 2023, “Floods and droughts are intensifying globally“, Nature Water
• Uhut Karaca: "Zu nass, zu trocken", F.A.Z. 22.3.2023

Kommentar zu Weinstudie:

• R. Allaby (2023): "Two domestications for grapes", Science, 2.3.23

Studie zur Kultivierung des Weines:

• Y. Dong et al. (2023): "Dual domestications and origin of traits in grapevine evolution", Science, 2.3.

Kommentar zum Schutz des Erdorbits:

• I. Napper et al. (2023): "Protect Earth’s orbit: Avoid high seas mistakes", Science, 9.3.

Zunehmende Störungen in Aufnahmen des Hubble-Weltraumteleskops:

• S. Kruk et al. (2023): "The impact of satellite trails on Hubble Space Telescope observations", Nature astronomy, 2.3.

Interviews mit Peter Galison:

Galison, Peter, and Trevor Paglen. “The Lives of Images.” Aperture 211 (2013): 32-39. Galison, Peter, and Elizabeth Kessler. “To See the Unseeable.” Aperture, 2019, 237, 73-77.

ESO Bilddatenbank ESO Videodatenbank

Die Links zu dieser Podcast-Folge:

• Justine Karst et al, Nature Ecology & Evolution, 2023, "Positive citation bias and overinterpreted results lead to misinformation on common mycorrhizal networks in forests"

• Meifeng Deng et al, Science Advances, 2023, "Tree mycorrhizal association types control biodiversity-productivity relationship in a subtropical forest"

Hintergründe zu ChatGPT: OpenAI-Blog: "ChatGPT: Optimizing Language Models for Dialogue", 30.11.22

T. Kung,…, V. Tseng: "Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models", PLOS Digital Health, 9.2.23

O. Nov, N. Singh, D. Mann: "Putting ChatGPT’s Medical Advice to the (Turing) Test", medRxiv, 23.1.23

A. Sarraju, D. Bruemmer, E. Van Iterson et al. "Appropriateness of Cardiovascular Disease Prevention Recommendations Obtained From a Popular Online Chat-Based Artificial Intelligence Model", JAMA, 3.2.23

Herbert Zech & Isabelle Céline Hünefeld, Medizinrecht Januare 2023, "Einsatz von KI in der Medizin: Haftung und Versicherung"

C. Bergero,… ,S. J. Davis (2022), "Pathways to net-zero emissions from aviation", Nature Sustainability, 30.1.202

IPCC-Report (2022): Mitigation of Climate Change

Veröffentlichung:

• C. Fonseca, …, L. Hurst: „People with more extreme attitudes towards science have self-confidencein their understanding of science even if this is not justified“, PLOS Biology, 24.1.2023
• Wissenschaftsbarometer 2022

Dunning-Kruger-Effekt:

• Kruger, J., Dunning, D. (1999): "Unskilled and Unaware of It: How Difficulties in Recognizing One's Own Incompetence Lead to Inflated Self-Assessments", Journal of Personality and Social Psychology

Hörerumfrage Podcast Wissen mit Gewinnspiel

Insekten als Nahrungsmittel:

• Arup Kumar Hazarika and Unmilan Kalita (2022): "Human consumption of insects", Science

Insekten als Futtermittel:

• Arnold van Huis, Laura Gasco (2022): "Insects as feed for livestock production", Science

Review zur Akzeptanz insektenbasierter Nahrung:

• T. Kröger et al. (2021): "Acceptance of Insect-Based Food Products in Western Societies: A Systematic Review", Frontiers in Nutrition

Link zur Hörerumfrage

Die Paper für diese Podcast-Folge:

• Sophia Tan et al, Nature Medicine, 2. Januar 2023, "Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave"

• CDC Covid Data Tracker, 2022, "Rates of laboratory-confirmed COVID-19 hospitalizations by vaccination status"

• Meredith David-Gardener et al, NEJM, 5. Januar 2023, "Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster"

• Samuel Ailsworth et al, Annals of Allergy, Asthma and Immunology, "Enhanced SARS-CoV-2 IgG durability following COVID-19 mRNA booster vaccination and comparison of BNT162b2 with mRNA-1273"

• Can Yue et al, bioRxiv (Preprint), 2023, "Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion"

S. Getzin et al. (2022), "Plant water stress, not termite herbivory, causes Namibia’s fairy circles", Perspectives in Plant Ecology, Evolution and Systematics, 20.10.22

A. M. Turing, (1952), "The chemical basis of morphogenesis", Philos. Trans. R. Soc. B 237, 37-72

Yannick Garcin et al, Nature, 2022, “Hydroclimatic vulnerability of peat carbon in the central Congo Basin“

L. Posiolova et al. (2022), "Largest recent impact craters on Mars: Orbital imaging and surface seismic co-investigation", Science, 27.10.22

D. Kim et al. (2022), "Surface waves and crustal structure on Mars", Science, 27.10.22

P. Voosen (2018), "NASA lander to probe interior of Mars", Science, 20.4.2018

B. Owens, Nature, "Energy crisis squeezes science at CERN and other major facilities", 12.10.2022

J. Müller-Jung, M. Lindinger, FAZ, "Energiekrise und Inflation bremsen die deutsche Spitzenforschung aus", 20.10.2022

Die Paper zu dieser Podcast-Folge:

Yunlong Cao et al, Preprint bioRxiv, 2022, "Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution"

Debra va Egeren et al, Preprint medRxiv, 2022, "Vaccines alone cannot slow the evolution of SARS-CoV-2"

Daniel Kelly et al, Jama Network, 2022, "Incidence of Severe COVID-19 Illness Following Vaccination and Booster With BNT162b2, mRNA-1273, and Ad26.COV2.S Vaccines"

Illustration der aktuellen "Varianten-Suppe von Raj Rajnarayanan

Morreall, John, "Philosophy of Humor", The Stanford Encyclopedia of Philosophy (Fall 2020 Edition), Edward N. Zalta (ed.)

Koji Inoue, Divesh Lala, Tatsuya Kawahara, "Can a robot laugh with you?: Shared laughter generation for empathetic spoken dialogue", Front. Robot. AI, 15 September 2022, Sec. Computational Intelligence in Robotics

Informationen des Nobelpreis-Stiftung:

Medizin:https://www.nobelprize.org/prizes/medicine/2022/summary/ Physik: https://www.nobelprize.org/prizes/physics/2022/summary/ Chemie: https://www.nobelprize.org/prizes/chemistry/2022/summary/

Tim Maudlin, "Philosophy of Physics: Quantum Theory", Princeton University Press 2019

Die Paper zu diesem Podcast:

• IEEFA-Analyse kommerzieller CCS-Techniken, Sept 2022, "The Carbon Capture Crux"

• Rong Wang et al, Nature, 2022, "Delayed use of bioenergy crops might threaten climate and food security"

• Kommentar: Gernot Wagner & Wolfram Schlenker, Nature, 2022, "Declining crop yields limit the potential of bioenergy"

Die Paper zu dieser Podcast-Folge:

• Europäische Zulassung Omikron-Impfstoffe "ECDC-EMA statement on booster vaccination with Omicron adapted bivalent COVID-19 vaccines"
• Ewen Callaway, Nature, 2022, "New Omicron-specific vaccines offer similar protection to existing boosters"
• Deborah Cromer et al, medRxiv, 2022, "Predicting the efficacy of variant-modified COVID-19 vaccine boosters"
• Susan Moir et al, medRxiv, 2022, "Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination"
• Michael Edelstein et al, npj Vaccines, 2022, "Association between BNT162b2 vaccination and reported incidence of post-COVID-19 symptoms: cross-sectional study 2020-21, Israel"
• Liu Schan-Lu et al, New England Journal of Medicine, 2022, "Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants"

Links:

- Artemis Programmbeschreibung der Nasa, September 2020

- Die Wissenschaft von Artemis I, Nature 24. August 2022:

- Beschreibung des Artemis-Programms, Nature 11. Mai 2022:

- Donald Trump: "Executive Order on Encouraging International Support for the Recovery and Use of Space Resources", 6. April 2020

- Moon Agreement der UN

Die Paper zu dieser Podcast-Folge:

• Covid-19 Host Genetics Intiative, Nature, 2022, "A first update on mapping the human genetic architecture of COVID-19"

• Laurent Bartolo et al, Science Immunology, 2022, "SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens"

• Eric Topol (Blog Ground Truths), 2022, "Immunity Walls"

• Esther Dawen Yu et al, Cell Host & Microbe, 2022, "Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic"

• Rouf Banday et al, Nature Genetics, 2022, "Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries"

Die Paper zu dieser Podcast-Folge:

• Matthew Jones et al, Reviews of Geophysikcs, 2022, "Global and Regional Trends and Drivers of Fire Under Climate Change"

• Jofre Carincer et al, Scientific Reports, 2022, "Global warming is shifting the relationships between fire weather and realized fire-induced CO2 emissions in Europe"

• Monica Ionita et al, J. of Hydrology: Regional Studies, 2022, "Long-term drought intensification over Europe driven by the weakening trend of the Atlantic Meridional Overturning Circulation"

Die Paper zu dieser Podcast-Folge:

Zur Anpassung an die Klimakatastrophe "Science"-Spezial):

• Damon Matthews et al, Science, 2022 "Current global efforts are insufficient to limit warming to 1.5°C"
• Michael Jakob et al, Science, 2022, "How trade policy can support the climate agenda"
• Nathalie Seddon, Science, 2022, "Harnessing the potential of nature-based solutions for mitigating and adapting to climate change"
• Giovanni Forzieri et al, Nature, 2022, "Emerging signals of declining forest resilience under climate change"

Zur Evolution der Sars-CoV-2-Variante Omikron:

• Anupriya Aggarwal et al, medRxiv, Preprint 2022, "SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern"

• Ann Katrin Reuschl et al, biorXiv, Preprint 2022, "Enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants BA.4 and BA.5"

Die Paper zu dieser Podcast-Folge:

Long- und Post-Covid im Gehirn:

• David Holdsworth et al, Plos One, 2022, "Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID"
• Anthony Fernández-Castañeda et al, Cell, 2022, "Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation"
• Denise Visser et al, medRxiv, 2022, "Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET"

Medikamentenstudien mit Ivermectin:

• Maria Popp, Stefanie Weibel Covhrane Review 2022, "Ivermectin gegen COVID-19: aktualisierter Cochrane Review findet keine Evidenz für einen Nutzen"

Aerosolo-Übertragung

• Daphne Duval et al, BMJ, 2022, "Long distance airborne transmission of SARS-CoV-2: rapid systematic review"
• Editorial BMJ, "Airborne SARS-CoV-2"

Die Paper zu dieser Podcast-Folge:

• Ferdinand Kosak, Iris Schelhorn, Marc Wittmann, Plos One, 2022, "The subjective experience of time during the pandemic in Germany: The big slowdown"

• Sophie Herbst, Ignacio Spiousas, Research gate (Preprint), 2022, "The Blursday Database: Individuals’ Temporalities in Covid Times"

• Catherine Reynolds et al, Science, 2022, "Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure"

• Pinkus Tober-Lau et al, Emerging Infectious Diseases Journal (CDC), 2022, "Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections"

Aktuelles Paper:

• K. Zhang, B. S. Gaudi, J. S. Bloom, "A ubiquitous unifying degeneracy in two-body microlensing systems", Nature Astronomy, 23.5.2022

Mathematik dahinter:

• K. Zhang, S. Gaudi: "A Mathematical Treatment of the Offset Microlensing Degeneracy", arXiv, 10.5.22

Blog-Post:

• J. S. Bloom, "Just the Beginning for AI & Science"

Die Paper und Links zu dieser Podcastfolge:

• Mariam Zachariah et al, Preprint 2022, "Climate Change made devastating early heat in India and Pakistan 30 times more likely"

• Oldrich Rakovec at al, Earth's Future 2022, "The 2018–2020 Multi-Year Drought Sets a New Benchmark in Europe"

• Dürremonitor Deutschland des Helmholtz-Zentrums für Umweltforschung (UFZ) in Leipzig

• Marina Romanello et al, Lancet, 2021, "The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future"

Die wissenschaftlichen Veröffentlichungen zum ersten Bild des Schattens von Sgr A*

Die erste Idee: Falcke, Heino ; Melia, Fulvio search by orcid ; Agol, Eric: "Viewing the Shadow of the Black Hole at the Galactic Center", The Astrophysical Journal, 2000

Derek J. de Solla Price: Science since Babylon. New Haven, CT, USA: Yale University Press 1961

Derek J. de Solla Price: "Networks of scientific papers", Science 1965

L. Bornmann, R. Mutz: "Growth rates of modern science: A bibliometric analysis based on the number of publications and cited references", arXiv 2014

Andy Extance: "How AI technology can tame the scientific literature", Nature, Sept. 2018

A. Belikov, A. Rzhetsky, J. Evans: "Prediction of robust scientific facts from literature", Nature Machine Intelligence, 28.4.22

Die Links zu dieser Podcast-Folge:

• Limin Hao et al, Nature Medicine, 2022, "Development of a clinical polygenic risk score assay and reporting workflow"

• Christian Arzov et al, International Journal of Cancer, 2022, "A randomized trial of risk-adapted screening for prostate cancer in young men—Results of the first screening round of the PROBASE trial"

• Informationen zur bundesweiten Medizininformatik-Initiative

Edward Bernays: „Propaganda - Die Kunst der Public Relations“ (1928), orange press

The Institute for Propaganda Analysis, Ed.: Alfred Lee, Elizabeth Lee, „The Fine Art of Propaganda“, (1939), Harcourt, Brace and Company New York

David E. Broockman, Joshua Kalla: "The manifold effects of partisan media on viewers’ beliefs and attitudes: A field experiment with Fox News viewers*", 3.4.22, preprint

Beth Anne Helgason, Daniel Effron: "It might become true: How prefactual thinking licenses dishonesty", Journal of personality and social psychology

Timo Spinde et al.: "How do we raise media bias awaress effectively? Effects of Visualizatoins to communicate bias", Plos One, 13.4.22,

• Stellungnahme Deutscher Ethikrat: Die Links zu dieser Podcast-Folge:

A. Buyx et al, April 2022, "Vulnerabilität und Resilienz in der Krise – Ethische Kriterien für Entscheidungen in einer Pandemie"

• IWF-Arbeitspapier: Rucir Agarwal, Jeremy Farrar et al., 5. April 2022, "A Global Strategy to Manage the Long-Term Risks of COVID-19"

• Infektionen-Anylse: COVID-19 Cumulative Infection Collaborators, Lancet, 2022, "Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis"

Schwedische Strategie: Nele Brusselaers et al.: "Evaluation of science advice during the COVID-19 pandemic in Sweden", Nature Humanities and Social Sciences Communications, 22.3.22

Interview mit Viola Priesemann: „Man kann Wissenschaftler sehr gut aufs Glatteis führen“

Gesammelte Daten zu Impfnebenwirkungen:

• Centers for Disease Control and Prevention (USA): "Selected Adverse Events Reported after COVID-19 Vaccination"
• Medicines & Healthcare products Regulatory Agency (UK): "Coronavirus vaccine - weekly summary of Yellow Card reporting"

Neue Studie in "Nature Communications":

• K.N. Singer et al.: "Large-scale cryovolcanic resurfacing on Pluto", 29.3.2022

Konvektionszellen in der Sputnik-Ebene:

• McKinnon, W. B. et al. "Convection in a volatile nitrogen-ice-rich layer drives Pluto’s geological vigour." Nature 534, 82–85 (2016).

IAU Informationssammlung Pluto

Die Paper zu dieser Podcast-Folge:

• Aktuelles Birbaumer-Paper:

Ujwal Chaudhary et al, Nature Communications, 2022, "Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training"

• Frühere Arbeiten Birbaumers, Gegenstand des DFG-Verfahren:

Ujwal Chaudhary et al, Plos Biology, 2017: "Brain–Computer Interface–Based Communication in the Completely Locked-In State"

• White Paper von Neuralink:

Elon Musk & Neuralink, Journal of Medical Internet Research, 2001, "An Integrated Brain-Machine Interface Platform With Thousands of Channels"

Hörerfragen: Aktueller Bericht der Medicines & Healthcare products Regulatory Agency auf der Grundlage von Yellow Card reporting, 17.3.22.

Die Paper zu dieser Podcast-Folge:

Zur Entwicklung der Pandemie:

• Peter Markov, Aris Katzourakis, Nikolaos Stilianikis, Nature Reviews Microbiology, 2022, "Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity"
• Christina Pagel, Science, 2022, "'Back to normal' is not enough"

Zur Maskendebatte:

• E. Coma et al.. 7.3.22: "Unravelling the Role of the Mandatory Use of Face Covering Masks for the Control of SARS-CoV-2 in Schools: A Quasi-Experimental Study Nested in a Population-Based Cohort in Catalonia (Spain)"
• CDC Morbidity and Mortality Weekly Report, 11.3.22: "SARS-CoV-2 Incidence in K–12 School Districts with Mask-Required Versus Mask-Optional Policies — Arkansas, August–October 2021"

Die Paper zu diesem Podcast:

• Heyden Metsky et al, Nature Biotechnology, 2022, "Designing sensitive viral diagnostics with machine learning"

• Asley Mason et al, Scientific Reports, 2022, "Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study"

• Vic-Fabienne Schumann et al, medRxiv, 2021, "COVID-19 infection dynamics revealed by SARS-CoV-2 wastewater sequencing analysis and deconvolution"

• Shelesh Agraval, medRxiv, 2021, "A pan-European study of SARS-CoV-2 variants in wastewater under the EU Sewage Sentinel System"

• ECDC & "EpiPulse"-Projekt, regelmäßig aktualisierte Situationsberichte

Die Paper zu dieser Podcast-Folge:

• Evidenzbasierte Impf-Fakten vom Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG): Gesundheitsinformation.de

• Akiko Iwasaki et al, Nature medicine, 2022, "Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination"

• Epidemiologisches Bulletion des RKI, Ausgabe 7/2022, "STIKO: 18. Aktualisierung der COVID-19- Impfempfehlung"

• Aktuelle Impfinformationen der europäischen Zulassungsbehörde EMA: Human Medicine Comitee

Die Paper zu dieser Podcast-Folge:

• Manmeet Singh et al, Cell Reports Medicine, 2022, "Antiviral agents for the treatment of COVID-19: progress and challenges"

• Jennifer Hammond et al, NEJM, 2022, "Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19"

• UK Health Security Agency, Februar 2022, "The effectiveness of vaccination against long COVID"

• RAPS Covid-Therapien-Tracker, 2022

Überblick mit Auflistung ethischer und juristischer Herausforderungen: I. Levchenko et al., "Mars Colonization: Beyond Getting There", Global Challenges 2019

Nasa und das Strahlungsproblem

Wie Hörnchen während des Winterschlafs ihre Muskelmasse halten: M. Regan et al.: "Nitrogen recycling via gut symbionts increases in ground squirrels over the hibernation season", Science, 27.1.22

Effektivität der Elektrolyse auf Mond und Mars: B. Lomax et al.: "Predicting the efficiency of oxygen-evolving electrolysis on the Moon and Mars", Nature Communications, 8.2.2022

Impfgerechtigkeit:

• Modellstudie: Ye et al.: "Equitable access to COVID-19 vaccines makes a life-saving difference to all countries", Nature Human Behaviour, 31.1.2022
• Kommentar von Samba Sow: "Global South cannot just live with COVID-19"
• Kommentar von Keymanthri Moodley: "Vaccine inequity is unethical"
• Kommentar von Tahir Amin: "Innovation alone won’t end COVID-19"
• Kommentar von Philani Mthembu: "Travel bans erode global trust"
• Kommentar von Anuradha Gupta: "COVAX can still end COVID-19 vaccine apartheid"
• Kommentar von Ayoade Alakija: "Global North and South must work hand in glove to stop COVID-19"
• Kommentar von Winnie Byanyima "HIV or COVID-19, inequity is deadly"
• Correspondence von Achal Prabhala und Alain Alsalhani "Developing countries can make the mRNA vaccines they need"

Hörerfragen:

Zu Fragen der Blutwäsche:

• "Hilferufe aus den Blutgefässen": FAZ.NET v. 5.1.2022

Zu Impfungen und Infektionen:

• Aus unserem Podcast "Brauchen Genesene jetzt noch eine Impfung" die Genfer Immunitätsstudie

Fragen von Betroffenen zu Long-Covid: Patienten-Leitlinie des AWMF

Die Paper für diese Podcast-Folge:

• Zum Nutzen der Impfung:

Paul Kuodi et al, medRxiv (Preprint), 2022: "Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients tested between March 2020 and November 2021"

Ziyad Al-Aly et al, Research Square (Preprint), 2021, "Long Covid after Breakthrough COVID-19: the post-acute sequelae of breakthrough COVID-19"

• Früherkennung von Long-Covid/Post-Covid:

Carlo Cervia et al, Nature Communications, 2022, "Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome"

• Persistenz der Viren im Körper:

Daniel Chertow et al, Research Square (Preprint), 2021, "SARS-CoV-2 infection and persistence throughout the human body and brain"

Kjetil Bjoernevik et al, Science, 2022, "Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis"

Die Paper zu dieser Podcast-Folge:

• Coronavirus Infection Survey des britischen Office for National Statistics, 19. Januar 2022, "Characteristics of people testing positive for COVID-19"

• Krammer-Studie/USA: Juan M. Carreno et al, Nature, 31.12.2021, "Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron"

• Eckerle-Studie / Genf: Meriem Bekliz et al, Preprint 2022, "Neutralization of ancestral SARS-CoV-2 and variants Alpha, Beta, Gamma, Delta, Zeta and Omicron by mRNA vaccination and infection-derived immunity through homologous and heterologous variants"

• Innsbruck-Studie: Annika Rössler et al, New England Journal of Medicine, 20. Januar 2022, "SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons"

• Südafrika-Studie: Khadija Khan et al, Preprint, 2022, "Omicron infection enhances neutralizing immunity against the Delta variant"

• Kanada-Studie: ArinjayBanerjee et al, bioRxiv, 13. Januar 2022, "Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants"

• Kalifornien-Studie: Benjamin Sievers et al, Science Translational Medicine, 13. Januar 2022, "Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses"

Die Paper zu dieser Podcast-Folge:

• Kinder-Studie aus USA_ Lindsay Wang et al, medRxiv, 2022, "COVID infection severity in children under 5 years old before and after Omicron emergence in the US"

• Virus-Dynamik im Harvard-Dashboard Stephen Kissler et al, 2022, "Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant"

• Genfer-Omikron-Studie Olha Puuhach et al, medRxiv, 2022, "Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron"

• Wissenschaftler-Aufruf British Medical Journal, 14. Januar 2022, "Europe must come together to confront omicron"

• T-Zellabwehr Heidi Ledford, Nature, 2022, "‘Killer’ immune cells still recognize Omicron variant"

Die Links zu den Missionen:

Artemis: https://www.esa.int/Science_Exploration/Human_and_Robotic_Exploration/Exploration/Gateway https://www.nasa.gov/sites/default/files/atoms/files/artemis_plan-20200921.pdf

Russische Mondmission Luna 25: https://nssdc.gsfc.nasa.gov/nmc/spacecraft/display.action?id=LUNA-25 https://www.esa.int/Science_Exploration/Human_and_Robotic_Exploration/Exploration/Luna

Japanische Mission SLIM: https://global.jaxa.jp/projects/sas/slim/ https://nssdc.gsfc.nasa.gov/nmc/spacecraft/display.action?id=SLIM

Indische Mondmission Chandrayaan-3: https://nssdc.gsfc.nasa.gov/nmc/spacecraft/display.action?id=CHANDRYN3

Südkoreanische Mondmission Korea Pathfinder Lunar Orbiter: https://nssdc.gsfc.nasa.gov/nmc/spacecraft/display.action?id=KPLO

Asteroidenmission Psyche: https://solarsystem.nasa.gov/missions/psyche/in-depth/ Asteroidenmission Lucy: https://solarsystem.nasa.gov/missions/lucy/in-depth/ Asteroidenmission DART: https://www.nasa.gov/planetarydefense/dart

ExoMars: https://www.dlr.de/rd/desktopdefault.aspx/tabid-2448/3635_read-59249/

Ariane 6:
https://www.dlr.de/rd/desktopdefault.aspx/tabid-2279/3410_read-47667/

Vega-C: https://www.esa.int/Enabling_Support/Space_Transportation/Launch_vehicles/Vega-C

SpaceX Starship: https://www.spacex.com/vehicles/starship/

Die Paper zu dieser Podcast-Folge:

Brian Laidlaw et al, Nature Reviews Immunology, 2021, "The germinal centre B cell response to SARS-CoV-2"

Wilfredo Garcia Beltran et al, meRxiv, 2021, "mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant"

Sarah Adamo, Nature, 2021, "Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection"

Lucy Loyal, Andreas Thiel et al, Science, 2021, "Cross-reactive CD4+T cells enhance SARS-CoV-2 immune responses upon infection and vaccination"

Andrew Redd et al, bioRxiv, 2021, "Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals"

Vergleich Pandemie und Infodemie:

• S. Briand et al.: "Infodemics: A new challenge for public health", Cell, 9.12.21

Was bestimmt das Interesse an neuen Informationen?

• C. Kelly & T. Sharot: "Individual differences in information-seeking", Nature Communications, 3.12.21

Vorschlag von Mega-Studien:

• K. Milkman et al.: "Megastudies improve the impact of applied behavioural science", Nature, 8.12.21

Positionspapier des Wissenschaftsrates:

• Wissenschaftskommunikation | Positionspapier (Drs. 9367-21), Oktober 2021

Die Paper zu diesem Podcast:

Juliet Pulliam et al, medRxiv, 2021, "Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa"

Salim S. Karim et al, Lancet, 2021, "Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic"

• Aktueller Situationsbericht des Scripps Institute: "Outbreak Info"

• Multicenter-Studie zur Wirksamkeit der Booster:

Alasdair Munroe et al, Lancet, 2021, "Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial"

Überblick Studie zur Wirksamkeit pandemischer Maßnahmen:

• A. Mendez-Brito, C. El Bcheraoui, F. Pozo-Martin: „Systematic review of empirical studies comparing the effectiveess of non-pharmaceutical interventions against Covid-19”, Journal of Infection, 19.6.2021

Lockdown-Müdigkeit in England:

• S. Ross et al.: „Household visitation curing the Covid-19 pandemic“, Scientific Reports, 25.11.2021

Beitrag der Ungeimpften zum Infektionsgeschehen in Deutschland:

• B. Maier, … , Cornelia Betsch, D. Brockmann: “Germany’s current Covid-19 crisis is mainly driven by the unvaccinated”, medRxiv preprint, 26.11.2021

Die Paper zu dieser Podcast-Folge:

• Fragwürdiges Harvard-Paper inkl. Faktencheck: S. V. Subramanian et al, European Hournal of Epidemiology, 2021, "Increases in COVID‑19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States" AFP-Faktencheck: "Studienautor dementiert: Diese Havard-Studie belegt nicht die Wirkungslosigkeit von Corona-Impfungen"

• Schwedische Studie zu nachlassender Immunität: Peter Nordström et al, Lancet-Preprint, 2021, "Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study"]

• Israelische Studie zu mRNA-Booster: Noam Barda et al, Lancet, 2021, "Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study"

• Englische Studie zu Boostern: Nick Andrews et al, Preprint medRxiv, "Effectiveness of BNT162b2 (Comirnaty, Pfizer-BioNTech) COVID-19 booster vaccine against covid-19 related symptoms in England: test negative case-control study"

• Saarland-Studie zu Kreuzimpfungen: Martina Sester et al, Preprint Research Square, 2021, "Immunogenicity and reactogenicity of heterologous Ad26.COV.2 and BNT162b2 vaccination"

Die Paper zu der Podcast-Folge:

• Petra Zimmermann et al, Arch.Child.Dis. (BMJ), 29021, "Should children be vaccinated against Covid-19"

• Hongru Li et al, medRxiv, 2021, "A need of COVID19 vaccination for children aged <12 years: Comparative evidence from the clinical characteristics in patients during a recent Delta surge (B.1.617.2)"

• William Moss et al. (Kommentar), Jama, 2021 ["Pediatric COVID-19 VaccinesWhat Parents, Practitioners, and Policy Makers Need to Know"

• ](https://jamanetwork.com/journals/jama/fullarticle/2786095)

• E.B. Walter et al, New England Journal of Medicine, 2021, "Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age"

Experimente der Mission "Cosmic Kiss", Übersicht des DLR

Übersicht der wissenschaftlichen Publikationen auf der Grundlage von ISS-Experimenten 2020

Bonus für Liebhaber: G. Wurm, J. Teiser 2021: "Understanding planet formation using microgravity experiments", Nature Reviews Physics

Die Links und Paper zu diesem Podcast:

• EMA, 25.10.2021:"COVID-19: EMA starts rolling review of molnupiravir"

• Merck Pressemitteilung vom 1. Oktober

• Vfa v. 25.=ktober 2021: Therapeutische Medikamente gegen die Coronavirusinfektion Covid-19

• Andrew Hill et al, Research Square, Preprint (!): "Ivermectin for COVID-19: addressing potential bias and medical fraud"

• Agatha Mikolajewska et al, Cochrane Library Review, "Colchicine for the treatment of COVID‐19"

Nature Artikel:

• Bianca Nogrady: "‘I hope you die’: how the COVID pandemic unleashed attacks on scientists", 13.10.2021
• Daten der Umfrage

Wissenschaftler-Statements des deutschen SMC zum Nature-Artikel

Wissenschaftler-Statements des britischen SMC zum Nature-Artikel

Die Paper zu dieser Podcast-Folge:

• Shup Feng et al, Nature Medicine, 2021, "Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection"

• Gesellschaft für Virologie, 2021, "Aktualisierte Stellungnahme zur Immunität von Genesenen"

• Einav Levin et al, NEJM, 2021, "Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months"

• Sarah Tartof et al, Lancet, 2021, "Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study"

• Maya Poon et al, Science Immunology, 2021, "SARS-CoV-2 infection generates tissue-localized immunological memory in humans"

• Elizabeth Anderson et al, medRxiv (Preprint), 2021, "SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared to SARS-CoV-2 mRNA vaccinations"

Nature Studie zum Einsatz von KI bei der Einreise nach Griechenland:

• H. Bastani et al. "Efficient and targeted COVID-19 border testing via reinforcement learning", Nature, 22.9.2021

Kommentar zur Studie:

• Z. Obermeyer: "A machine-learning algorithm to target COVID testing of travellers", Nature, 22.9.21

Britische Studie zur Identifikation von Covid-19-Erkrankungen auf der Grundlage früher Symptome:

• L.S. Canas et al. "Early detection of COVID-19 in the UK using self-reported symptoms: a large-scale, prospective, epidemiological surveillance study", The Lancet Digital Health, 1.9.2021

KI im Einsatz zur Vorhersage der Eigenschaften von Virusvarianten:

• C. Chen et al.: "Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2", PNAS, 23.8.21

Die Paper zu dieser Podcast-Folge:

Stratil JM et al, Cochrane Review, 2021, "Non-pharmacological measures implemented in the setting oflong-term care facilities to prevent SARS-CoV-2 infections and theirconsequences: a rapid review (Review)"

RKI-Papier: "Aktualisierung der ControlCOVID-Strategie zur Vorbereitung auf den Herbst/Winter 2021/22" vom 22. September 2021

Julian Hirt et al, F1000Research (Preprint), 2021, "Clinical trial research on COVID-19 in Germany – a systematic analysis"

Die Publikationen zu dieser Podcast-Folge:

Science Media Center (SMC), Press Briefing, Transkript, 13. Sept. 2021, "Die deutsche Impfkampagne stockt –Gründe, Lösungen, Perspektiven"

SMC-Briefing, Videomitschnitt, Youtoube: https://www.youtube.com/watch?v=vXOQcr6kE68

Mark Navin, Social Theory and Practise, 2013, "Competing Epistemic Spaces: How Social Epistemology Helps Explain and Evaluate Vaccine Denialism"

Die Paper zu dieser Podcast-Folge:

• Terence Stephenson et al, Preprint, Research Square, 2021, "Long COVID - the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study"

• CDC Morbidity and Mortality Weekly Report (MMWR), Weekly, 2021, "Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021"

• Simriti Malapaty, Nature, 2021, "Kids and COVID: why young immune systems are still on top"

• Longcovid-Informationsseite (in Englisch):- "Long Covid Kids"

Die Paper zu dieser Podcast-Folge:

Stefan Moritz et al, Nature Communications, 2021, "The risk of indoor sports and culture events for the transmission of COVID-19"

Jenifer A.E. Smith et al, Preprint, 2021, "Public health impact of mass sporting and cultural events in a rising COVID-19 prevalence in England"

Boris Revollo et al, Lancet, 2021, "Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial"

Josep Llibre et al, Annals of Internal Medicine, 2021, "Screening for SARS-CoV-2 Antigen Before a Live Indoor Music Concert: An Observational Study"

• F.A.Z.-Artikel:

Sibylle Anderl vom 25. August 2021, "Wie gefährlich sind Großveranstaltungen?"

Wirken die Impfungen auch gegen Delta?

• Englische Studie: J. Bernal et al., 21.7.21, "Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant", NEJM
• Schottische Studie mit Hospitalisierungsangaben: A. Sheikh et al., 26.6.21, "SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness", The Lancet

Können Geimpfte Überträger sein? C. Brown et al., 30.7.21, "Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021", Morbidity and Mortality Weekly Report (MMWR), CDC Preprint vom Imperial College: P. Elliott et al., "REACT-1 round 13 final report: exponential growth,high prevalence of SARS-CoV-2and vaccine effectiveness associated with Delta variantin England during May to July2021", Preprint Israelische Studie: M. Bergwerk et al., 28.7.21., "Covid-19 Breakthrough Infections in Vaccinated Health Care Workers", NEJM Studie zur Verbreitung von Delta in den USA: A. Bolze et al., 21.6.21, "Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States", Preprint Tausendfache Virenlast: B. Li et al., 23.7.21, "Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant", Preprint Preprint aus Singapur, Po Yin Chia et al, 31.7.21, „Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study“, medRxiv Preprint zur Lambda-Variante, Izumi Kimura et al, "SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance", bioRxiv

Die Paper zu dieser Podcast-Folge:

Craig Fenwick et al, Science Translational Medicine, 2021, "A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma"

Dung Nguyen et al, Eurosurveillance, 2021, "SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data"

Preprint (!): Judith Kannenberg et al, medRxiv, 2021, "Sensitivity of SARS-CoV-2 antibody tests with late convalescent sera"

Positionspapier des Verbands der Diagnostica-Industrie, 2021, "Antikörpertestung förderteffiziente Impfstrategien gegen COVID-19. Impferfolg beschleunigen + Vertrauen erhöhen + Wissenverbessern"

Zielimpfquote für Deutschland:

• Epidemiologisches Bulletin 27, 8.7.21 (online 5.7.21) „Welche Impfquote ist notwendig, um Covid-19 zu kontrollieren?“, O. Wichmann et al.

Beschreibung des genutzten SEIR-Modells:

• Epidemiologisches Bulletin 13, 1.4.21 "Einfluss von Impfungen und Kontaktreduktionen auf die dritte Welle der Sars-CoV-2-Pandemie und perspektivische Rückkehr zu prä-pandemischem Kontaktverhalten", S. Scholz et al.

Plädoyer gegen vollständige Öffnung in UK:

• D. Gurdasani et al., „Mass infection is not an option: We must do more to protect our young", The Lancet, Correspondence, 7.7.21

Wichtigkeit heterogener Netzwerke:

• M. Cevik und S. D. Baral, „Networks of Sars-Cov-2 transmission“; Science, 8.7.21

Interpretation des starken Rückgangs der Fallzahlen im Mai in Deutschland:

• Janos Gabler, Tobias Raabe, Klara Röhrl, Hans-Martin von Gaudecker, "The Effectiveness of Strategies to Contain Sars-CoV-2: Testing, Vaccinations, and NPIs", arXiv:2106.11129v2, 23.6.21

Die Paper zu dieser Podcast-Folge:

Ravinrad Gupta et al, Research Square (Preprint), 2021, "SARS-CoV-2 B.1.617.2 Delta variant emergence and vaccine breakthrough"

Emma Wall et al, Lancet, 2021, "AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC"

Aziz Sheikh et al, Lancet, 2021, "SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness"

Chris Davis et al, medRxiv, "Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination"

Anegla Choi et al, bioRxiv, 2021, "Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants"

Lingshu Wang et al, Science, 2021, "Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants"

Amerikanische Studie zum Effekt der Pandemie auf Paarbeziehungen:

• L. Neff et al.: "Blame the Pandemic: Buffering the Association Between Stress and Relationship Quality During the COVID-19 Pandemic", 21.6.21,
• Social Psychological and Personality Science

Deutsche Studie zum Effekt der Pandemie auf Familien mit jungen Kindern:

• N. Christner et al.: "Children’s psychological well-being and problem behavior during the COVID-19 pandemic: An online study during the lockdown period in Germany", 23.6.21, Plos One

FAZ-Glosse zum Thema: Wie Paare vom Virus profitiert haben könnten

"Werbepartner dieser Episode ist der BASF-Podcast "ELEMENTary". Mit ELEMENTary die Welt der Chemie von heute und Morgen erleben. Mehr Infos unter https://www.basf.com/podcast"

Die Paper zu dieser Podcast-Folge:

• Zur Ansteckungsgefahr: Jovana Stojanovic et al, Frontiers in Public Health, 2021, "COVID-19 Is Not the Flu: Four Graphs From Four Countries"

• Zum Vergleich der Krankheitsbilder: Marci Osuchowski et an. Lancet Respiratory Medicine, 2021, "The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity"

• Zu Sterbedaten von Covid-19: The Institute for Health Metrics and Evaluation (IHME), 2021, "Estimation of total mortality due to COVID-19"

• Zu Long-Covid und Spätfolgen: Michael Marshal, Nature, 2021, "The four most urgent questions about long COVID"

NuW-Artikel:

• "Ein vergessener Planet?", Natur und Wissenschaft 9.6.2021

Frühe Klage über zu wenig Venus und zu viel Mars:

• "How Important a Planet is Venus?", 4.1.1971, Nature Physical Science

Ablehnung der Venus-Missionen 2017:

• "Jilted again, Venus scientists pine for their neglected planet", 13.1.2017, Science

Überblicksartikel zur Venus:

• "Venus: The Atmosphere, Climate, Surface, Interior and Near-Space Environment of an Earth-Like Planet", F. Taylor, H. Svedhem, J. Head III, 23.1.2018, Space Science Reviews

Aktuelle Missionen:

• Presseerklärung der Nasa zu DAVINCI+ und VERITAS, 2.6.2021
• Presseerklärung der Esa zu EnVision, 10.6.2021

Die Paper zu dieser Podcast-Folge:

Immunreaktionen von Krebs-Patienten:

• Erin Bange et al, Nature Medicine, 2021 "CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer"

• Tatjana Bilich et al, Cancer Discovery, 2021 "Preexisting and post-COVID-19 immune responses to SARS-CoV-2 in cancer patients"

• Amir Massaweh et al, Jama Oncology, 2021 "Evaluation of Seropositivity Following BNT162b2 Messenger RNA Vaccination for SARS-CoV-2 in Patients Undergoing Treatment for Cancer"

• Lova Sun et al, Jama Oncology, 2021 "Immune Responses to SARS-CoV-2 Among Patients With Cancer"

Impfantwort bei Organtransplantierten

• Olivier Marion et al, Annals of Internal Medicine, 2021 "Safety and Immunogenicity of Anti–SARS-CoV-2 Messenger RNA Vaccines in Recipients of Solid Organ Transplants"

Impfbereitschaft bei Autoimmun-Leiden

• Laura Boekel et al, Lancet Rheumatology, 2021 "Perspective of patients with autoimmune diseases on COVID-19 vaccination"

Die Paper zu dieser Podcast-Folge:

• Zur Impfbereitschaft:

COSMO - Aktuelle Auswertungen des Covid-19-Snapshot Monitoring

COVIMO-Studie des RKI " Impfverhalten, Impfbereitschaft und -akzeptanz in Deutschland"

Christopher Holzmann-Littig et al, medRxiv, 2021, "COVID-19 vaccination acceptance among healthcare workers in Germany"

• Zur Psychologie der Impfakzeptanz:

Patrick Sturgis et al, Nature Human Behaviour, 2021, "Trust in science, social consensus and vaccine confidence"

Eric Merkely et al, Nature Human Behaviour, 2021, "Anti-intellectualism and the mass public’s response to the COVID-19 pandemic"

Lisa Rosenbaum, NEJM, 2021, "Escaping Catch-22 — Overcoming Covid Vaccine Hesitancy"

• Zur Impfpflicht:

Katrin Schmelz, PNAS, 2021, "Enforcement may crowd out voluntary support for COVID-19 policies, especially where trust in government is weak and in a liberal society"

In der Kritik stehende Modelle/Extrapolationen:

• RKI-Situationsbericht vom 13. März mit Exponentialfit der Variantenentwicklung
• TU-Simulation von Wissenschaftlern um Kai Nagel: Modell, Methodik

Podcast-Verweis: Folge vom 28. Januar "Wie entscheidet man richtig, wenn vieles unsicher ist?"

Frage der Saisonalität von Sars-CoV-2:

• Carlson et al. 27.8.2020: "Misconceptions about weather and seasonality must not misguide COVID-19 response", Nature Communications
• Chen et al. 27.4.2021: "Climate and the spread of COVID-19", Nature Communications

Nichtlineares Verhalten / Kipppunkte:

• Scarselli et al., 10.5.2021: "Discontinuous epidemic transition due to limited testing", Nature Communications

Die Paper zu diesem Podcast:

• Zur Dauer der Immunantwort:

Eric Laing et al, medRxiv, 2021 "SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity"

• Antikörper-Antwort auf Infektion (Kölner Studie):

Kanika Vanshylla et al, Cell Host & Microbe, 2021, "Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans"

• Immun-T-Zell-Antwort nach Impfung:

Kathleen Gallagher et al, bioRxiv, 2021, "SARS-CoV-2 T-cell immunity to variants of concern following vaccination"

• Immunantwort bei Krebskranken:

Leticia Monin et al, Lancet Oncology, 2021 "Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study"

Studie über die epidemiologische Wirkung des Impfprogramms in Israel:

• H. Rossmann, … , E. Segal, 19.4.2021, "COVID-19 dynamics after a national immunization program in Israel", Nature Medicine

Kommentar zu Impfanreizen:

• R. Wilf-Miron, V. Myers, M. Saban, 20.4.2021, "Incentivizing Vaccination Uptake - The 'Green Pass' Proposal in Israel", JAMA Viewpoint

Kommentar zum Impfpass:

• M. A. Hall, D. M. Studdert, 31.3.2021, "'Vaccine Passport' Certification - Policy and Ethical Considerations", New England Journal of Medicine

Hintergründe des israelischen Impfprogramms:

• A. Reichardt, 9.4.2021, "Der israelische Sonderweg", Deutsches Ärzteblatt, 118:14

Impfbereitschaft in Deutschland:

• RKI: "COVID-19 Impfquoten-Monitoring in Deutschland (COVIMO) –3. Report (Kurzbericht)", 28.4.21

Die Paper zu dieser Podcast-Folge:

• Übersicht der forschenden Arzneihersteller, VfA (in deutsch):

"Therapeutische Medikamente gegen die Coronavirusinfektion Covid-19"

• S-3-Leitlinien der Fachgesellschaften

"Empfehlungen zur stationären Therapie von Patienten mit Covid-19"

• Lancet-Studie zum Asthmaspray

Sanjay Ramakrishnan et al, Lancet Respiratory Medicine, 2021, "Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial"

• Nasenspray mit Rotalgen-Wirkstoff Carragelose (Preprint, noch nicht begutachtet)

Juan Figueroa et al, medRxiv, 2021 "Efficacy of a nasal spray containing Iota-Carrageenan in the prophylaxis of COVID-19 in hospital personnel dedicated to patients care with COVID-19 disease A pragmatic multicenter, randomized, double-blind, placebo-controlled trial (CARR-COV-02)"

• Prophylaxe vor/nach Sars-CoV-2-Exposition ("Pille danach")

Kyle Rosenke et al, Nature Communications, 2021 "Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model"

• Entzündungshemmer aus Herbstzeitlose (Colchicin), neues Preprint

Leonard Chiu et al, medRxiv, 2021, "Colchicine use in patients with COVID-19: a systematic review and meta-analysis"

Erfolgreiche Ausgangssperren in Französisch Guayana:

• A. Andronico et al., 12.3.2021: "Evaluating the impact of curfews and othermeasures on SARS-CoV-2 transmission in FrenchGuiana", Nature Communications

Schädliche Ausgangsbeschränkungen in Toulouse: C. Dimeglio et al., 31.1.2021: "Side effect of a 6 p.m curfew for preventing the spread of SARS-CoV-2: A modeling study from Toulouse", Journal of Infection

Erfolgreiche Ausgangssperren, insbesondere für über Sechzigjährige in Frankreich: C. Baunez et al. 11.2021: "An Early Assessment of Curfew and Second COVID-19 Lock-Down on Virus Propagation in France", medRxiv

Internationale Vergleichsstudien:

• Haug et al., 16.11.2020: "Ranking the effectiveness of worldwide COVID-19 government interventions", Nature Human Behaviour (Reduktion von R um maximal 0,13)
• M. Sharma et al., 26.3.2021: "Understanding the effectiveness of government interventions in Europe’s second wave of COVID-19", medRxiv (Reduktion von R um 13 Prozent)
• J. Brauner et al., 19.2.2021: "Inferring the effectiveness of government interventions against COVID-19", Science (Bringt nur geringen Zusatzeffekt)

Weitere Studie: Huber, M., & Langen, H. (2020): "Timing matters: the impact of response measures on COVID-19- related hospitalization and death rates in Germany and Switzerland." Swiss Journal of Economics and Statistics (kein großer Zusatzeffekt in Deutschland 2020)

Mobilitätsstudien: Niederlande: Nederlands Studiecentrum Criminaliteit en Rechtshandhaving, 5.2.2021: „Results of the NSCR Curfew Study", Pre-print version 1/NSCRFactsheetCurfewBehavioralStudyPreprint_050221.pdf RKI Report:

Die Paper für diese Podcastfolge:

Zur Evolution des Sars-CoV-2-Erregers:

• Kevin McCormick et al, Science, 2021 "The emerging plasticity of SARS-CoV-2"

Zum Einfluss der Impf-Abstände:

• Sarah Cobey, Marc Lipsitch et al, Nature Reviews Immunology, 2021, "Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination"

Effektivität des Astra-Zeneca-Impfstoffs:

• Katherine Emary et al, Lancet, 2021, "Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial"

Kommentar zur Astra-Zeneca-Studie:

• Rogier Sanders et al, Lancet, 2021, "Pandemic moves and countermoves: vaccines and viral variants"

Fluchtmutation gegen "Sputnik V":

• Satoschi Ikegame et al, medRxiv, 2021, "Qualitatively distinct modes of Sputnik V vaccine-neutralization escape by SARS-CoV-2 Spike variants"

Workshop Zusammenfassung:

• H. Socas-Navarro et al. 2021, "Concepts for future missions to search for technosignatures", Acta Astronautica 182:446 oder arXiv-Datenbank

Workshopseiten:

• Nasa-Workshop 2018, 26.-28. September, "Nasa Technosignatures"
• Nasa-Workshop 2020, 3.-7. August, "Technoclimes"

Die Paper zu dieser Podcast-Folge:

Ani Nalbandian et al, Nature Medicine Review, 2021: "Post-acute Covid-19” https://www.nature.com/articles/s41591-021-01283-z.pdf"

Carol Sudre et al, Nature Medicine, 2021, "Attributes and predictors of long COVID"

Phosp-Covid Collaborative Group et al, medRxiv, 24. März 2021, "Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study"

Effekt der Verzögerung der Zweitimpfungen:

• B.F. Maier, … , M. Meyer-Hermann, … , K. Lauterbach und D. Brockmann, "Potential benefits of delaying the second mRNA COVID-19 vaccine dose", arXiv 1. März 2021

Koordination von Öffnungen und Impfungen:

• S. Bauer, … , V. Priesemann, "Relaxing restrictions at the pace of vaccinationincreases freedom and guards against furtherCOVID-19 waves in Europe", arXiv 10.3.

Korrelation zwischen Variantenhäufigkeit, Inzidenz und Krankenhausbelegung:

• T. Mitze, J. Rode, "Early assessment of epidemiological trendsassociated with SARS-CoV-2 variants of concern in Germany", medRxiv 10.3.21

Britische Modellierungsstudie zum Einfluss der Impfungen

• S. Moore et al., "Vaccination and Non-Pharmaceutical Interventions: When can the UK relax about COVID-19?", Lancet Infect Dis., 18.3.21

Die Paper zu dieser Podcast-Folge:

• Zur Rolle von B- und T-Zellen in der Sars-CoV-2-Immunantwort:

Alessandro Sette & Shane Crotty, Cell, 2021, "Adaptive immunity to SARS-CoV-2 and COVID-19"

• Zur Immun-Flucht von Sars-CoV-2-Varianten (Preprint)

Alison Tarke et al, bioRxiv, 2021, "Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees"

• Zur Immun-Flucht nach Impfungen (Preprint)

Donal Skelly et al, RQ, 2021, "Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern"

• Zur frühen Reaktion der T-Zellen:

Anthony Tan et al, Cell Reports, 2021, "Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients"

• Zu möglichen Lücken im T-Zell-Repertoire

Benedikt Agrere et al, Science Immunology, 2021, "SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses"

• Zur erhöhten Sterblichkeit von Infektionen mit B.1.1.7-Variante

Robert Challen et al, British Medical Journal, 2021, "Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study"

Studie zur Kontaktverfolgung und der Rolle des Freundschaftsparadox:

• Sadamori Kojaku, Yong-Yeol Ahn et al., "The effectiveness of backward contact tracing in networks", Nature Physics, 25.2.2021

Soziologische Studie zum Freundschaftsparadox:

• Scott L. Feld, "Why Your Friends Have More Friends Than You Do", American Journal of Sociology, 1991

Informationen des RKI zur Kontaktverfolgung

H. Pifarré et al., 18.2.2021, "Years of life lost to COVID-19 in 81 countries", Scientific Reports

A. Rommel et al., "COVID-19-Krankheitslast in Deutschland im Jahr 2020 - Durch Tod und Krankheit verlorene Lebensjahre im Verlauf der Pandemie", Deutsches Ärzteblatt, 118, 9, 5.3.2021

Altersverteilung der Verstorbenen in Deutschland: RKI-Situationsbericht vom 23.2.2021

Die Paper zu diesem Podcast:

Fallbericht eines Covid-19-Patienten:

J. Tuan et al, British Medical Journal, 2021, "A new positive SARS- CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?"

Retrospektive Studie:

M. Sheehan et al, medRxiv, 16.2. 2021, "Reinfection Rates among Patients who Previously Tested Positive for COVID-19: a Retrospective Cohort Study"

Prospektive Studie mit Marine-Rekruten:

A. Letizia et al, medRxiv, 29.1.2021, - "SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: 4a prospective cohort study"

Krankenhaus-Studie (aus Dezember):

S. Lumley et al, NEJM, 2020, "Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers"

Science-Paper:

• M. Monod et al., 2.2.2021, "Age groups that sustain resurging COVID-19 epidemics in the United States", Science

• Plus Supplements dazu

Daten in Deutschland:

• Aktueller Situationsbericht vom RKI mit altersaufgeschlüsselten Inzidenzen vom 9.2.2021 (Abbildung 4)

Entscheidende Faktoren für die Aerosolerzeugung:

• D. Edwards et al., 23.2.2021 (print), "Exhaled aerosol increases with COVID-19 infection, age, and obesity", PNAS

Kinder & Schüler mit B.1.1.7-Infektionen:

• Sarah Brookman et al, 10.02.2021, Lancet Child & Adolescent Health, „Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people“

Die Paper zu diesem Podcast:

Thomas Williams, Wende Burgers, Lancet Respiratory Medicine, 2021, "SARS-CoV-2 evolution and vaccines: cause for concern?"

Kevin McCarthy et al, Science, 2021, "Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape"

Houriiyah Tegally et al, Nature Medicine, 2021, "Sixteen novel lineages of SARS-CoV-2 in South Africa"

Warum beim Umgang mit der Pandemie moderne Entscheidungstheorie helfen kann:

• L.Berger et al., 26.01.2021, "Rational policymaking during a pandemic", PNAS

Beispiel für minimax-regret-Strategie;

• C.Manski, 6.8.2020, "Forming COVID-19 Policy Under Uncertainty", Journal of Benefit-Cost Analysis

Warum wir Menschen uns so schwer tun, in unsicheren Situationen unsere Interpretation zu revidieren:

• N. Chater, 27.7.2020, "Facing up to the uncertainties of COVID-19", Nature Human Behaviour- Aufzählungs-Text

Wissenschaftsphilosophischer Lesetipp:

• Sandra Mitchell, 2008, "Komplexitäten. Warum wir erst anfangen, die Welt zu verstehen.", Kapitel: "Handeln in einer komplexen Welt", Suhrkamp Frankfurt am Main

• RKI Mobility Monitor

• Google Mobilitätsdaten

• Italienische Studie zum Zusammenhang von Reisetätigkeit und Pandemie-Ausbreitung: A. Crteni, L. Di Francesco, M. Martino: "How mobility habits influenced the spread of the Covid-19 pandemic: Results from the Italian case study", Science of the Total Environment, 25.5.2020

• Beispiel für eine auf Mobilitätsdaten beruhende Modellierung: Zhou et al. "Effects of human mobility restrictions on the spread of COVID-19 in Shenzhen, China: a modelling study using mobile phone data", Lancet 2.8.2020

• Deutsche Studie zu Mobilitätsdaten und Netzwerkeigenschaften: F. Schlosser, … , D. Brockmann: "COVID-19 lockdown induces disease-mitigating structural changes in mobility networks", PNAS, 29.12.2020

• Studie auf der Grundlage von GPS-Daten: S.Chang,… ,J. Leskovec: "Mobility network models of COVID-19 explain inequities and inform reopening", Nature 10.11.2020

Die Paper für diese Podcast-Folge:

A. Lindner, C. Denkinger, F. Mockenhaupt et al., medRxiv, 2021, "SARS-CoV-2 patient self-testing with an antigen-detecting rapidtest: a head-to-head comparison with professionaltesting"

S. Hoehl, S. Ciesek et al, mexRxiv, 2020, "At-home self-testing of teachers with a SARS-CoV-2 rapid 1antigen test to reduce potential transmissions in schools2Results of the SAFE School Hesse Study"

M. Mina & K. Andersen, Science, 2021, "COVID-19 testing: One size does not fit all"

M. L. Bastos et al, Annals of Internal Medicine, 2021, 1. "The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs"

Die Paper für diese Podcast-Folge:

Emma Hodcroft, Adam Lauring, Jama 2021, "Genetic Variants of SARS-CoV-2—What Do They Mean?"

Erik Volz et al, medRxiv 2020, "Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data"

Allison Greaney et al, bioRxiv 2021, "Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies"

Houriiyah Tegally et al, medRxiv 2020, "Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa"

SA Kemp et al, medRxiv 2020, "Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion"

Die Paper für diese Podcast-Folge:

Claudius Gottschalk et al, Deutsches Ärzteblatt, 2020, "Antigentests auf SARS-CoV-2: Es zählt auch die Schnelligkeit"

Michael Mina, NEJM, 2020, "Rethinking Covid-19 Test Sensitivity — A Strategy for Containment"

Daniel Larremore et al, Science Advances, 2020, "Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening"

Andreas Lindner et al, European Respiratory Journal, "Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with self-collected anterior nasal swab versus professional-collected nasopharyngeal swab"

Antigentest-Liste der zugelassenen Produkte in Deutschland:

Bundesinstitut für Arzneimittel und Medizinprodukte, "Antigen-Tests zum direkten Erregernachweis des Coronavirus SARS-CoV-2"

Antigentests: unabhängige Beurteilungen kommerzieller Angebote

Claudia Denkinger, Lukas Brümmer, "Rapid antigen tests for the diagnosis of a SARS-CoV-2 infection"

Deutsche Modellierungsstudie zu verschiedenen Szenarien der Kontrolle des Infektionsgeschehen:

• S. Contreras, …, V. Priesemann, 23.11.2020 “Towards a long-term control of covid-19 at low case numbers”, preprint arXiv.org

Kanadisch-amerikanische Studie zur Wirkung des öffentlichen Krisenbewusstseins auf die Pandemiedynamik:

• J. S. Weitz et al., "Awareness-driven behavior changes can shift the shape of epidemics away from peaks and towards plateaus, shoulders, oscillations", PNAS 1.12.2020

Ad-hoc-Stellungnahme der Leopoldina vom 8.12.:

• "Coronavirus-Pandemie: Die Feiertage und den Jahreswechsel für einen harten Lockdown nutzen"

Die Paper zu dieser Podcastfolge:

Petra Bacher et al., Immunity, 2020, “Low avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals andhumans with severe COVID-19”

Manish Sagar et al, The Journal of Clinical Investigation, 2020, "Recent endemic coronavirus infection is associated with less severe COVID-19"

Hintergrund zur T-Zell-Immunität:

Annika C. Karlosson et al, Science Immunology, 2020, "The known unknowns of T cell immunity to COVID-19"

Zur Antikörper-Kreuzimmunität:

Kevin Ng et al, Science, 2020, „Preexisting and de novo humoral immunity to SARS-CoV-2 in humans”

Aktueller Review:

• S. Kumar & H. P. Lee, 24.11.2020, "The perspective of fluid flow behavior of respiratory droplets and aerosols through the facemasks i context of Sars-CoV-2", Physics of Fluids

Aktuelle Studie zur Wirksamkeit von 11 verschiedenen Gesichtsbedeckungen:

• J. Pan et al., 20.11.2020, "Inward and outward effectiveness of cloth masks, a surgical mask, and a face shield", medRxiv

Dänische Studie zur Wirksamkeit von Masken vor Ansteckung:

• Bundgaard et al., 18.11.2020, "Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers - A Randomized Controlled Trial", Annals of Internal Medicine

Studien zur mehrfachen Verwendung von N95-Masken: Fischer et al. 24.4.2020, "Assessment of N95 respirator decontamination and re-use for Sars-CoV-2", medRxiv Q.-X. Ma et al., 22.4.2020, "Decontamination of face masks with steam for mask reuse in fighting the pandemic Covid-19: Experimental supports", Journal of Medical Virology

Die Veröffentlichungen zu diesem Podcast:

Selbsterfahrungsbericht eines Intensivmediziners: Jeffrey Siegelman, JAMA, 2020, "Reflections of a COVID-19 Long Hauler"

Aktueller FAZ-Artikel (mit weiterführenden Beispielen aus der Kardiologie): Nicola von Lutterotti, "Das Drama danach"

Klinische Nachsorge: Vineet Chopra et al, Annals of Internal Medicine, 2020, "Sixty-Day Outcomes Among Patients Hospitalized With COVID-19"

Long-Covid-Symptome: Carole Sudre et al, medRxiv, 2020, "Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms 1collected by the Covid Symptoms Study App"

Zum Erschöpfungssyndrom: Liam Townsend et al, PlosOne, 2020, " Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection"

"Nature"-Studie, Chang et al. 10.11.2020, "Mobility network models of Covid-19 explain inequities and inform reopening"

"News and views"-Artikel zur Studie, Kevin C. Ma & Marc Lipsitch "Big data and simple models to track Covid-19"

Google Mobilitätsreports

Schnelle Plots der Google Mobilitätsdaten für Deutschland und Frankreich (Gerne selbst nochmal schöner plotten ;) )

Die Paper für diesen Podcast:

Brazeau et al., 2020 "COVID-19 Infection Fatality Ratio: Estimates from Seroprevalence. Report 34"

Megan Driscoll et al, Nature, 2020, "Age-specific mortality and immunity patterns of SARS-CoV-2"

ECDC, Weekley Surveillance Report

J. Cunningham et al, Jama Internal Medicine, 2020:"Clinical Outcomes in Young US Adults Hospitalized With COVID-19"

Einführung in Interferon-Genetik-Studien:

David Beck and Ivona Aksentijevich, Science, 2020: "Susceptibility to severe COVID-19" Daniel Brito et al, JACC, 2020: "High Prevalence of Pericardial Involvement in College Student-Athletes RecoveringFrom COVID-19"

Zentraler Überblicks-Artikel: Lee et al., "The engines of Sars-CoV-2 spread", "Science", 23.10.20

Review zu Ansteckungen in Haushalten: Fung et al., "The household secondary attack rate of SARS-CoV-2: A rapid review", "Clinical Infectious Diseases", 12.10.20.

RKI Situationsbericht 27.10. mit Grafik zu Infektionsumfeldern

38. Epidemiologisches Bulletin "Infektionsumfeld von erfassten COVID-19-Ausbrüchen in Deutschland"

Die Paper für diesen Podcast:

Peter Doshi, BMJ, 2020, „Will Covid-19 vaccines save lives? Current trials aren’t designed to tell us”

Barton Haynes et al, Science Translational Medicine, 2020, “Prospects for a safe COVID-19 vaccine”

Akiko Iwasaki et al, Cell, 2020, “Why and How Vaccines Work”

Jama Editorials, 12.10.2020:

• Harvey Fineberg: "The Toll of Covid-19"
• Howard Bauchner, Phil Fontanarosa: "Excess Deaths and the Great Pandemic 2020"

Jama Research Letters, 12.10.2020:

• Steven Woolf et al.: "Excess Deaths From Covid-19 and Other Causes, March-July 2020"
• Alyssa Bilinski, Ezekiel Emanuel: "Covid-19 and Excess All-Cause Mortality in the US and 18 Comparison Countries"

Jama Viewpoints, 12.10.2020:

• David Cutler, Lawrence Summers: "The Covid-19 Pandemic and the $16 Trillion Virus"
• Naomi Simon, Grenn Saxe, Charles Marmar: "Mental Health Disorders Related to Covid-19-Related Deaths"

- Lisa Cooper, DAvid Williams: "Excess Deaths From Covid-19, Community Bereavement, and Restorative Justice for Communities of Color"

Übersterblichkeit in 21 Industriestaaten, Nature Medicine, 14.10.2020:

• Vasilis Kontis et al.: "Magnitude, demographics and dynamics of the effect of the first wave of the Covid-19 pandemic on all-cause mortality in 21 industrialized countries"

Fallverstorbenenraten in Deutschland, Pre-Print 12.10.2020

• Matthias Linden et al.: "The foreshadow of a second wave: An analysis of current Covid-19 fatalities in Germany"

Die Paper für diesen Podcast:

• Monoklonale Antikörper

Jakob Kreye et al, Cell, 2020, "A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology ina COVID-19 hamster model"

J. Kreyer et al, Nature Reviews Immunology, 2020, "Do cross-reactive antibodies cause neuropathology in COVID-19?"

Pressemitteilung von Regeneron: "Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients"

Review vom 31.7. A. Renn et al, Trends in Pharmacological Science, 2020, "Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2"

• Nanobodies

Leo Hanke et al, Nature Communications, 2020, "An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction"

Michael Schoof et al, bioRxiv, 2020 "An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an 1inactive conformation"

Die Paper für diesen Podcast:

Beatrice Nash et al., medRxiv: "The impact of high frequency rapid viral antigen screening on COVID-19 spread and outcomes: a validation and modeling study"

Julia Young et al, NEJM, 2020_ "Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing"

Xiong Ding et al, Nature Communications, 2020, "Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay"

Leben auf der Venus? Die Studie in "Nature Astronomy", Greaves et al. (2020), "Phosphine gas in the cloud decks of Venus" Supplements zur Venus-Studie

====================================

Editorial "The climate issue", erschienen in "Nature Astronomy"

Australische Übersichtsstudie: "The imperative to reduce carbon emissions in astronomy"

Kommentar zur CO2-Bilanz des MPIA in Heidelberg: "An astronomical institute’s perspective on meeting the challenges of the climate crisis"

Kommentar zum Energieverbrauch astrophysikalischer Simulationen: "The ecological impact of high-performance computing in astrophysics"

Vergleich der CO2-Bilanz einer Konferenz digital vs. analog: "The carbon footprint of large astronomy meetings"

Weitere Studien, die nicht explizit zur Sprache kamen:

Klimabilanz eines astronomischen Observatoriums: "Measuring carbon emissions at the Canada–France–Hawaii Telescope"

Einfluss des Klimawandels auf astronomische Beobachtungen: "The impact of climate change on astronomical observations"

Die Paper für diesen Podcast:

"A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants", B. Dearlove et al, PNAS, 2020

"Evolution of the COVID-19 vaccine development landscape", Tung Tanh Le et al, Nature, 2020

"Science"-Paper: Laurette Piani et al., 28.8.2020: "Earth's water may have been inherited from material similar to enstatite chondrite meteorites"

"Science"-Kommentar: Anne H. Peslier, 28.8.2020: "The origins of water"

Biographischer Exkurs -- Schneelinien und was man sonst noch daraus lernen kann ;-): Anderl et al. (2016): "Probing the CO and methanol snow lines in young protostars. Results from the CALYPSO IRAM-PdBI survey", A&A

Glosse: "Woher kommt all das Wasser?"

Die Paper für diesen Podcast:

Ching-Yao Lai et al, Nature, 2020: Vulnerability of Antarctica’s ice shelves to meltwater-driven fracture

Thomas Slater et al, The Cryosphere Discussions, 2020 Review Article: Earth’s ice imbalance

Daisuke Hirano et al, Nature Communications, 2020 Strong ice-ocean interaction beneath Shirase Glacier Tongue in East Antarctica

Susheel Adusumilli et al, Nature Geoscience, 2020, Interannual variations in meltwater input to the Southern Ocean from Antarctic ice shelves

Die Paper für unseren Podcast:

Jerome Hadjadj et al, Science (2020), "Immune analysis in fifty patients uncovers 'hallmark' of severe COVID-19"

Anna Aschenbrenner et al, medRxiv (2020), "Disease severity-specific neutrophil signatures in blood 1 transcriptomes stratify COVID-19 patients"

Dimitris Bertsimas et al, medRxiv (2020), "COVID-19 Mortality Risk Assessment: An International Multi-Center Study"

Euromomo-Zusammenfassung: "Excess all-cause mortality during the COVID-19 pandemic in Europe - preliminary pooled estimates from the EuroMOMO network, March to April 2020", 2.7.2020

Jama-Editorial zur Mortalität und Morbidität: "Mortality and Morbidity - The measure of a Pandemic"; 1.7.2020

S. Woolf et al. "Excess Deaths From Covid-19 and Other Causes, March-April 2020", Jama 1.7.2020 D. Weinberger et al. "Estimation of Excess Deaths Associated With the Covid-19 Pandemic in the United States, March to May 2020", Jama 1.7.2020

Einige Paper zu unserem Podcast:

• Diabetes durch Sars-CoV-2-Infektion:

F. Rubino et al, NEJM (2020), "New-Onset Diabetes in Covid-19"

J. Li et al, Diabetes, Obesity and Metabolism (2020), COVID ‐19 infection may cause ketosis and ketoacidosis

Noel Pratheepan Somasundaram et al, The Journal of the Endocrine Society (2020), The Impact of SARS-Cov-2 Virus Infection on the Endocrine System

• Nieren-Komplikationen:

J. Hirsch et al, Clinical Investigation (2020), Acute kidney injury in patients hospitalizedwith COVID-19

• Inflammatorisches Syndrom bei Kindern:

Michael Levin, NEJM (2020), Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic

Zu schwer für einen Neutronenstern, zu leicht für ein Schwarzes Loch - das neue Ligo-Paper: GW190814: Gravitational Waves from the Coalescence of a 23 Solar Mass Black Hole with a 2.6 Solar Mass Compact Object

Quantenkorrelationen im Ligo-Experiment: Quantum correlations between light and the kilogram-mass mirrors of LIGO

Die Paper für dieses Podcast-Folge:

Xin Long et al (2020, Nature Medicine, "Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections"

Mary Marovich et al (2020), Jama, "Monoclonal Antibodies for Prevention and Treatment of COVID-19"

Zum Thema auch interessant u.a.:

Davide F. Robbian et al, (20209; Nature "Convergent antibody responses to SARS-CoV-2 in convalescent individuals"

Thomas Rogers et al (2020), Science "Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model" Thomas F. Rogers

Die im Podcast besprochenen Paper:

Lucy van Dorp, Francois Balloux et al. (2020), Infection, Genetics and "Evolution, Emergence of genomic diversity and recurrent mutations in SARS-CoV-2"

Nsoesie Elaine Okanyene, Benjamin Rader, Yiyao L. Barnoon,Lauren Goodwin, and John S. Brownstein. (2020) Preprint, Harvard Library DASH "An Analysis of hospital traffic and searchengine data in Wuhan China indicates early disease activity in the Fall of 2019"

Studie des Kepler-160 Systems: René Heller et al. 2020, "Transit least-squares survey - III. A 1.9 R_Earth transit candidate in the habitable zone of Kepler-160 and a nontransiting planet characterized by transit-timing variations", A&A

Studie zum Einfluss von Staub in den Atmosphären von Exoplaneten: Ian Boutle et al. 2020, "Mineral dust increases the habitability of terrestrial planets but confounds biomarker detection", Nature Communications

Unsere Paper aus dem Podcast:

D.R. Boulware et al, (2020) New England Journal of Medicine, "A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19"

Mandeep R.Mehra et al, (2020) Lancet "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"

Michael Takla et al, (2020) medRxiv "Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety"

Unsere im Podcast besprochenen Paper:

J.-L. Casanova & Covid Human Genetic Effort et al, Cell (2020): "A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection"

Zur Rolle von "Schlüssel"-Bausteinen:

C. Bhattacharyya et al, bioRxiv (2020) "Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of TMPRSS2and MX1 Genes"

Außerdem zur Rolle von ACE2 und zur Frage der Covid-19-Anfälligkeit von Männern:

I. Sama et al, European heart Journal (2020) "Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors"

Britische Studie zu klinischen Risikofaktoren:

The OpenSAFELY Collaborative et al., medRxiv (2020) "The factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients"

T. Britton et al., 8.5.2020, "The disease-induced herd immunity level for Covid-19 is substantially lower than the classical herd immunity level" - schwedische Modellstudie zur Änderung der Herdenimmunität in heterogenen Gruppen

M. G. M. Gomes et al., 2.5.2020, "Individual variation in susceptibility or exposure to SARS-CoV-2 lowers the herd immunity threshold" - andere Modellstudie mit abweichendem Ansatz zur Repräsentation von Heterogenität. Annahme: Diejenigen mit der größten Ansteckungsgefahr stecken auch die meisten an.

Heinsberg Studie, H. Streeck et al. (15 Prozent der Getesteten mit Antikörpern)

Österreich: repräsentative Stichprobe in 27 Risikogemeinden liefert knapp 5% in der Vergangenheit Infizierte

Schwedische Modellstudie zum Anteil der Infizierten in der Region Stockholm, die zum 1. Mai auf 26 Prozent geschätzt wird.

Unsere Paper aus bisher noch ungeprüften Originalpublikationen:

Korber B. et al, 2020, bioRxiv, "Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2" https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1

Lanjuan Li et al, 2020, MedRxiv, "Patient-derived mutations impact pathogenicity of SARS-CoV-2" https://www.medrxiv.org/content/10.1101/2020.04.14.20060160v2

Außerdem ein Überblick in unserem FAZ-Artikel "Das verwunschene Virus", auch online auf FAZ.NET mit dem Titel: "Wohin driftet die Pandemie?"

https://www.faz.net/aktuell/wissen/medizin-ernaehrung/mutierte-gene-von-sars-cov-2-wohin-driftet-die-corona-pandemie-16754535.html?premium

Studie des Effekts der chinesischen Reiseeinschränkungen: Chinazzi et al. , 24. 4. 2020: “The effect of travel restrictions on the spread of the 2019 novel coronarivus (Covid-19) outbreak”, Science 368, 395:

Modell-Studie zu den Effekte verschiedener Maßnahmen auf die Ausbreitung einer Pandemie in Großbritannien und den Vereinigten Staaten: Ferguson et al. 2006: “Strategies for mitigating an influenza pandemic.“, Nature 442:

Zusätzliche Informationen über die Funktionsweisen und Ergebnisse des Modells: Ferguson et al. 2006: “Supplements: Strategies for mitigating an influenza pandemic.“, Nature 442:

Die Liste der behandelten Paper und wertvolle Zusatzinformationen:

Science, 2020, M. Wadman et al.: "How does Coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes" https://www.sciencemag.org/news/2020/04/how-does-coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-brain-toes

Nature Immunology Review, 2020, Xuetao Cao: "Covid-19: Immunopathology and its implications for therapy" https://www.nature.com/articles/s41577-020-0308-3

Zum Thema Zytokin-Sturm: Journal of Microbioal Agents, 2020: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118634/pdf/main.pdf

Webpage mit wöchentlichen Prognosen des Imperial College London

Nouvellet et al. 2017: "A simple approach to measure transmissibility and forecast incidence"; Ebola-Studie, in der erklärt wird, wie aus den Daten die Reproduktionszahl ermittelt wird, um damit Vorhersagen zu ermöglichen

Webpage mit Prognosen des IHME

Murray et al. 2020: "Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator-days and deaths by US state in the next 4 months"; Prognosemethode des IHME

Expertenvergleich von Thomas McAndrew auf github

Zusammenfassung der Expertenprognosen

**Hier die 5 ausgewählten Paper zum Thema: **

Respiratory virus shedding in exhaled breath and efficacy of face masks Nancy H.L. Leung et al, (2020) Nature Medicine

Could SARS-CoV-2 be transmitted via speech droplets? [Philip Anfinrud et al (2020), MedRxiv] (https://www.medrxiv.org/content/10.1101/2020.04.02.20051177v1.full.pdf)

The coronavirus pandemic and aerosols: Does COVID-19 transmit via expiratory particles? [Sima Asadi et al, (2020), Journal Aerosol Science and Technology ] (https://www.tandfonline.com/doi/full/10.1080/02786826.2020.1749229?scroll=top&needAccess=true)

Transmission Potential of SARS-CoV-2 in viral Shedding Observed at the University of Nebraska Medical Center Joshua L Santarpia et al, (2020) MedRxiv

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets [Young-Il Kim et al, (2020) Cell Host & Microbes] (https://marlin-prod.literatumonline.com/pb-assets/journals/research/cell-host-microbe/PDFs/chom_2285_preproof.pdf)

Wissenschaftsphilosophischer Artikel "Model Evaluation: An Adequacy-for-Purpose View" von Wendy Parker

Historisches SIR-Modell "A Contribution to the Mathematical Theory of Epidemics" von Kermack & McKendrick (1927)

RKI-Modellierung "Modellierung von Beispielszenarien der Sars-CoV-2-Epidemie in Deutschland" von M. an der Heiden & U. Buchholz, 20. März 2020

Modellierungsstudie des Imperial College London zur Situation in den Vereinigten Staaten und Großbritannien "Impact of non-pharmaceutical interventions (NPIs) to reduce Covid-19 mortality and healthcare demand", 16. März 2020

Australische Validierungs-Studie: "Comparison of an Agent-based Model of Disease Propagation with the Generalised SIR Epidemic Model", 2009

Chenguang Shen et al (2020), JAMA

https://jamanetwork.com/journals/jama/fullarticle/2763983?guestAccessKey=57013f7d-97c6-46b8-b355-1245926c6548&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_03282020

John Roback (2020), JAMA, Editorial

https://jamanetwork.com/journals/jama/fullarticle/2763982?guestAccessKey=1e6f5d6a-8a7a-428e-bd95-276d3f128776&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=032720

Arturo Casadevall, Journal of Clinical Investigation https://www.jci.org/articles/view/138003

Studie an Passagieren des Kreuzfahrtschiffs “Diamond Princess”: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.10.2000180

Studie an aus China nach Japan ausgeflogenen Reisenden: https://www.ncbi.nlm.nih.gov/pubmed/32179137

Studie anhand Kontakt-basierter Fallsuche https://www.medrxiv.org/content/10.1101/2020.03.03.20028423v2

Kristian Andersen et al (2020), Nature Medicine, "The proximal origin of Sars-CoV-2" https://www.nature.com/articles/s41591-020-0820-9.pdf

Wei Luo et al.: The role of absolute humidity on transmission rates of the COVID-19 outbreak https://www.medrxiv.org/content/10.1101/2020.02.12.20022467v1.full.pdf

Jingyuan Wang: "High Temperature and High Humidity Reduce the Transmission of COVID-19” https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3551767

Blog von Marc Lipsitch/Harvard https://ccdd.hsph.harvard.edu/will-covid-19-go-away-on-its-own-in-warmer-weather/

Mohammad Sajadi "Temperature, Humidity and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3550308

Modellierung auf der Grundlage bekannter Corona-Viren: https://www.medrxiv.org/content/10.1101/2020.02.13.20022806v2.full.pdf

Weiterführende Paper zur Saisonalität von Virenerkrankungen:

Micaela Elvira Martinez (2018) "The calendar of epidemics: Seasonal cycles of infectious diseases" https://micaelamartinezbakker.files.wordpress.com/2018/11/martinez_me_2018.pdf

D. Fisman (2018) "Seasonality of viral infections: mechanisms and unknowns” https://www.sciencedirect.com/science/article/pii/S1198743X14610910

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