50 avsnitt • Längd: 65 min • Månadsvis
The Neuro Network discusses the lighthearted side of complex science. Join us as we delve into world(s) of neuroscience, physiology, health, wellness, and philosophy. Nick is a neuroscientist and physiologist in Madison, Wisconsin.
The podcast The Neuro Network is created by Nick Burgraff, PhD. The podcast and the artwork on this page are embedded on this page using the public podcast feed (RSS).
Join us as we take a look into a new feature of fentanyl and other opioids in the body. What do they do? How do they work? And why could they be devastating? Tune in to learn.
In this episode, we explore how orexin neurons in the brain help us prioritize exercise over tempting distractions like delicious food. Discover the science behind this brain-powered 'gym coach' and learn why some people are better at resisting temptation—giving us fresh insights into motivation, decision-making, and the battle between brain and cravings.
Paper: Tesmer, A. L., Li, X., Bracey, E., Schmandt, C., Polania, R., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons mediate temptation-resistant voluntary exercise. Nature Neuroscience, 1-9.
Join us as we explore the world of sleep at high altitudes. Discover how thin air impacts breathing and sleep patterns, and delve into scientific studies that shed light on how our bodies adapt to these extreme environments. Tune in to unravel the mysteries of sleeping among the stars and learn how to enhance your rest on your next high-altitude adventure.
Paper: https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP285397
Ibrahim, Abubaker, et al. "Effects of periodic breathing on sleep at high altitude: a randomized, placebo‐controlled, crossover study using inspiratory CO2." The Journal of Physiology (2024).
This week, we dive into the enigma of whether the universe is locally real, exploring the profound ways our perceptions mold reality and how neural network states govern our consciousness. Join us as we unravel the intricate dance between observation, cognition, and the very fabric of existence.
This week we're talking all things injuries. How do you train with an injury? How do you prevent injuries? And how do you come back from an injury? Nick breaks his collarbone and Mark drowns while snorkeling.
In this episode, we dive into the complex world of pain, exploring the intricate neuroscience behind opioids and understanding their impact on the brain. Our guest, Jamie Moffa is an expert in both the scientific and podcasting spheres, offering unique insights into how these powerful medications influence the brain and the challenges they present in both treatment and public perception. Join us as we bridge the gap between advanced scientific understanding and accessible communication, shedding light on a topic of profound relevance in today's world.
In Plain English Podcast: https://inplainenglishpod.org/
Zach is back and we're talking all things alkaline and hydrogen water. Does it really help? Can changing the pH of your water unlock an elixir to eternal life? Or is it all a bunch of nonsense? Tune in to find out what we think.
Zach is back. Join us on this illuminating journey where we discuss the intoxicating smells of Jiu-Jitsu, construction of simple electronic and robotic devices, and delve into the intricacies of the scientific review process.
In this episode, we dive into the intricate science of weight management, exploring beyond the notion of calories in, calories out. We examine how various factors like sleep, stress, genetics, and the body's complex metabolic processes interplay in determining weight gain or loss. Join us for a fascinating journey through the physiological and psychological aspects of weight management.
Dive into the cutting-edge realm of optogenetics. In this episode we explore how light is being used to sculpt the future of stem cell research. We dissect a groundbreaking study that uses blue light to direct stem cells into cartilage, paving the way for advancements in regenerative medicine. Join us as we illuminate the intricate orchestration of cells and light, unfolding the potential of this revolutionary technology in tissue engineering and beyond.
Paper: https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01514-0#%20
Humphreys, P. E., Woods, S., Bates, N., Rooney, K. M., Mancini, F. E., Barclay, C., ... & Kimber, S. J. (2023). Optogenetic manipulation of BMP signaling to drive chondrogenic differentiation of hPSCs. Cell Reports, 42(12).
In this episode, we delve into the fascinating world of neural networks that govern social interactions. Join us as we explore groundbreaking research using optogenetics and chemogenetics to unravel the roles of key brain areas in forming and maintaining social bonds. Discover the intricate dance between the brain's circuits and our social world, shedding light on the complex interplay that underpins our every interaction.
Paper: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002343
Rojek-Sito, K., Meyza, K., Ziegart-Sadowska, K., Nazaruk, K., Puścian, A., Hamed, A., ... & Knapska, E. (2023). Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction. PLoS biology, 21(11), e3002343.
In this episode, we're joined by Dr. Pamela Lein, a renowned neurotoxicologist from UC Davis, to delve into the intricate world of environmental neurotoxins. We explore the hidden dangers of chemicals like PCBs in our everyday environment, their profound effects on brain development and function, and the innovative strategies being developed to mitigate these risks. Join us as we uncover the critical intersection between our health and the toxins that silently surround us, and gain invaluable insights from Dr. Lein's pioneering research in this vital field.
Dive into the dynamic relationship between aging and brain health in this enlightening episode, where we explore a pivotal study on how exercise influences motor cortical plasticity in older adults. Uncover the nuanced ways our brain's capacity for adaptation responds to physical activity as we age, and what this means for maintaining cognitive vitality throughout our golden years. Join us as we discuss the implications of this research for personal and how we can all keep our minds as active as our bodies, no matter our age.Curtin, D., Cadwallader, C. J., Taylor, E. M., Andrews, S. C., Stout, J. C., Hendrikse, J. J., ... & Coxon, J. P. (2023). Ageing attenuates exercise-enhanced motor cortical plasticity. Journal of Physiology
In this episode, we delve deep into groundbreaking research that explores the profound relationship between psychedelics, neuroplasticity, and the BDNF-TrkB pathway. We unpack the potential of psychedelics as powerful modulators of brain function, their implications for depression treatment, and the challenges that lie ahead. Join us as we navigate the intricate dance of molecules, shedding light on the therapeutic promise of these once-controversial compounds.
Paper: Moliner, R., Girych, M., Brunello, C.A. et al. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci 26, 1032–1041 (2023). https://doi.org/10.1038/s41593-023-01316-5
Dive into an enlightening discussion with Serena Michaels-Pitman, PhD as we explore the intersection of neuroscience and artificial intelligence. This episode uncovers how research into astrocytes, the unsung heroes of the brain, is revolutionizing AI and missile navigation systems. Join us to comprehend how our brain's complexities can reshape the frontiers of technology. Don't miss this fascinating journey that blends neuroscience, AI, and aerospace innovation into a compelling narrative about our future.
John Kahan joins us for an in-depth dive into the advancements in the battle against Sudden Infant Death Syndrome (SIDS). John is the Chief Data Analytics Emeritus at Microsoft, and the Founder and Chairman of the Board of the Aaron Matthew SIDS Research Guild of Seattle Children's Hospital. John has decades of experience in data management and analytics and he, along with his team have created a truly translational program in an effort to ensure that no parent experiences the loss of a child ever again.
Zach and Nick dive into all things comparative biology. Topics include dog anal glands, giraffe cardiovascular physiology, dolphin research, and ponies.
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and those of guests and not professional organizations affiliated.
Trevor Day, PhD joins us for a dive into the world of high altitude physiology research. Learn what it takes to conduct human physiological research on the slopes of Mt. Everest in Nepal. Trevor is a Professor of Physiology at Mt. Royal University, and and all around great guy.
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and those of guests and not professional organizations affiliated.
Sam Louie is a psychotherapist, author, and Emmy-Award Winning former television journalist. Sam and Zach join us to discuss the interplay between mental health, therapy, and exercise. We even get Zach to go through a live therapy session on-air. To learn more:
Sam Louie- http://www.samlouiespeaks.com/
Sam's upcoming book- https://www.barnesandnoble.com/w/passport-to-shame-sam-louie-ma-lmhc/1140296610
Trauma Informed Jiu-Jitsu- https://www.psychologytoday.com/us/blog/minority-report/202303/trauma-informed-jiu-jitsu
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and those of guests and not professional organizations affiliated.
How do we control the brain with lasers? Optogenetics has revolutionized the field of neuroscience and opened to the door to understanding specific neural circuits. Join us as we take a look into the innerworkings of optogenetics and shed light on new studies involving anxiety and the heart.
Papers:
https://www.nature.com/articles/s41586-023-05748-8
https://www.nature.com/articles/nn1525
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and those of guests and not professional organizations affiliated.
Brock Grill, PhD joins us for an in-depth look at what it takes to develop rare disease models and study novel receptor signaling pathways. Brock is a neuroscientist and Professor at the Center for Integrative Brain Research at Seattle Children's. He is also a Professor of Pediatrics at the University of Washington. His lab focuses on molecular players and cellular processes involved in neurodevelopmental disorders, neurodegenerative disease and opioid drug addiction.
To learn more:
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and those of guests and not professional organizations affiliated.
Ultra endurance athletes Tracy and Peter Flucke join us for a dive into the world of extreme endurance. Together they biked across the entire U.S. while sitting a mere 6 inches apart from one another on a tandem bicycle. Listen to learn about the mindset, physiology, psychology, and neuroscience of what it takes to endure this incredible challenge. Their amazing journey is documented in their book, "Coast to Coast on a Tandem: Our Adventure Crossing the USA on a Bicycle Built for Two".
To learn more:
https://www.instagram.com/webikeetc/?hl=en
https://webikeetc.wordpress.com/
https://www.webike.org/our-book/
https://www.facebook.com/CoasttoCoastonaTandem
https://www.facebook.com/peter.flucke
https://www.facebook.com/webikeetc
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Coltan Scrivner, PhD of the Recreational Fear Lab joins us for a fascinating dive into the neuroscience and psychology of fear. Learn what makes humans fear, and what draws us to enjoy haunted houses and horror films.
Coltan Scrivner: https://www.coltanscrivner.com/
Recreational Fear Lab: https://cc.au.dk/en/recreational-fear-lab/
Publications:
Psychology and neurobiology of horror movies: https://psyarxiv.com/b8tgs/
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Join Nick and Zach as they dive into the foundations of exercise physiology. Topics discussed include energy utilization, cardiac function, muscular utilization, breathing, and much more.
https://www.theneuronetwork.org/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Ben Armstrong of Netherworld Haunted House joins us to discuss the art and science of fear. Located in Atlanta, Georgia, Netherworld is one of the most highly acclaimed haunted houses in the U.S. and was recognized as the #1 haunted house in America in 2017. Join us as we dive into the innerworkings of fear and discuss all things spooky.
Papers:
Haunted House Field Study:
https://journals.sagepub.com/doi/pdf/10.1177/0956797620972116
Fear Conditioning:
https://www.pnas.org/doi/abs/10.1073/pnas.0334049100
Little Albert:
https://www.sciencedirect.com/science/article/abs/pii/S0149763405001065
https://psycnet.apa.org/record/1979-25006-001
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Two former fat-guys, Nick and Zach dive into the mindset of obesity. Together they've lost a total of 270lbs. Listen in to hear about the trials, tribulations, and science of weight-loss.
Papers:
Brain dopamine and obesity:
https://pubmed.ncbi.nlm.nih.gov/11210998/
Serotonin, food intake, and obesity:
https://pubmed.ncbi.nlm.nih.gov/11210998/
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Nick and Zach dive into neuromodulators, cocaine addicted mice, and when the "fight or flight" system fails.
Papers:
https://www.nature.com/articles/nn0698_132
https://www.pnas.org/doi/abs/10.1073/pnas.1707822114
https://www.nature.com/articles/s41380-021-01181-3
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
What is fascia? Christopher Rodousakis joins us to discuss the innerworkings of the essential tissue layer beneath our skin. Christopher is an exercise physiologist and founder of ALIGN, a Fascial Laboratory, Education Center and Private Training Facility headquartered in the heart of Washington, DC.
Papers:
https://www.bodyworkmovementtherapies.com/article/S1360-8592(11)00156-2/fulltext
https://www.sciencedirect.com/science/article/abs/pii/S1360859202000670
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
How are memories formed? Can cannibalistic worms eat the memories of others? Zach and Nick discuss the basic unit of memory within the brain.
Papers:
Planaria: Memory Transfer through Cannibalism Reexamined: https://www.science.org/doi/10.1126/science.146.3641.274
A Manual of Psychological Experiments in Planaria: https://ase.tufts.edu/biology/labs/levin/resources/documents/PlanarianManual.pdf
Memory Transfer:
https://www.science.org/doi/10.1126/science.153.3736.658
*Disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional or medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated.
Part two of the Neuroscience of Breathing. Can modulating our breath change our brain behavior? We take a dive into the neural circuitry connecting your breathing centers to higher order regions controlling consciousness and emotion. We also discuss how large scale brain rhythms emerge, and how they're measured.
Papers:
https://www.frontiersin.org/articles/10.3389/fncir.2016.00115/full
https://www.frontiersin.org/articles/10.3389/fnana.2020.00058/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275985/#B52
https://pubmed.ncbi.nlm.nih.gov/35259917/
*disclaimer: The information in this show is for entertainment purposes only, and is not to be taken as professional medical advice. Similarly, the views expressed on this show represent my own and not professional organizations affiliated*
In with the good, out with the bad. In this episode we discuss the ins and outs of the respiratory control network. Why do we breathe? How do we breath? And what does this have to do with goats?
Papers mentioned:
Ventilatory and integrated physiological responses to chronic hypercapnia in goats
-https://pubmed.ncbi.nlm.nih.gov/30211447/
Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the Ventral Respiratory Column of awake and sleeping goats
-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996971/
Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals
-https://www.science.org/doi/abs/10.1126/science.1683005
Microcircuit synchronization and heavy tailed synaptic weight distribution augment preBötzinger Complex bursting dynamics
-https://pubmed.ncbi.nlm.nih.gov/36400528/
Pacemaker neurons and neuronal networks: an integrative view
-https://pubmed.ncbi.nlm.nih.gov/15582367/
Neuromodulation and the orchestration of the respiratory rhythm
En liten tjänst av I'm With Friends. Finns även på engelska.