From the Spectrum: Finding Superpowers with Autism

For today, just a brief introduction to research beginning at UT-Austin, University of Texas at Austin, led by Dr. Francisco Gonzalez-Lima. The study is called: Effects of Transcranial Infrared Light Stimulation on Symptoms of Autism Spectrum Disorder. In the link below, it is Study #2.

Dr. Francisco Gonzalez-Lima https://dellmed.utexas.edu/directory/francisco-gonzalez-lima

Research Link (Study #2) https://labs.la.utexas.edu/gonzalez-lima/participate-in-our-research/

Research Team https://labs.la.utexas.edu/gonzalez-lima/team/

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process.

A valuable consideration is the roles our eyes have on brain development, which we cover as well.

Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/

Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6

Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669

Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/care

Rudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037

The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e0

0:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins

5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin and Choroid Plexus

7:06 Melanin and Melanopsin through the body and biochemistry

8:39 Fruit Tree Example from Dr. Kruse

9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution

14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following

17:21 Gaze Attention

18:02 Joint Attention

19:12 Studies on Infants; Pierce et al, 2019

25:00 Wen et al, 2022

27:03 Keehn et al, 2024 and Early Autism Evaluations (EAE)

29:25 Rudling et al, 2024

32:15 Wrap-Up/Final Thoughts

34:55 Reviews/Ratings, Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.

He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.

Dr. Frye shares many figures during the conversation so the listener can follow along.

Dr, Richard Frye https://drfryemdphd.com

CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub

Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495

0:00 Dr. Richard Frye

6:13 Intro into mitochondria & energy production, various disease & dysfunction

11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics

16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain

20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine

26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria

30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation

34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression

42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis

45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)

54:54 Future Research

59:58 Wrap up, Reviews/Ratings

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.

Jack Kruse https://www.patreon.com/DrJackKruse/posts

Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.

Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle

Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation

0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration

4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)

6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)

8:25 Glycolysis

10:03 Citric Acid cycle

12:02 OXPHOS

13:51 Cytochrome I

15:07 Cytochrome II

16:08 Cytochrome III

17:10 Cytochrome IV and creating water

19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism

29:20 Cytochrome V and ATPase; Chromophores

33:56 Evolution and losing electrons; Autism and modern health complications

37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies

40:23 Reviews/Ratings and contact info

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: [email protected]

In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.

The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?

B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.

Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests

2:51 Autism and ADHD; Neurodiversity; and some problems in society

7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication

13:27 Autistic Phenotypes

19:01 ADHD Phenotypes

21:41 Specifiers and Lumping Contrasting Phenotypes

33:18 Medication and ODD (Oppositional Defiant Disorder) Rant

35:42 Autism conundrum with ADHD

38:45 Reviews/Ratings and Contact Info

Hopp: https://www.hopp.bio/fromthespectrum

X: https://twitter.com/rps47586

email: [email protected]

My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost.

Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology.

We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community.

The Mu Rhythm Bluff https://www.amazon.com/Mu-Rhythm-Bluff-Jonathan-Mitchell-ebook/dp/B00BQN84GM/ref=sr_1_1?crid=2UHATAWKAT5YA&dib=eyJ2IjoiMSJ9.eocnp6hSIjLZqAuzxnIcPw.vv03H-Vx-BeqtHx4_dYo4W6QomZdOkuZ4JEBPgbA-IQ&dib_tag=se&keywords=the+mu+rhythm+bluff&qid=1724157644&sprefix=the+mu+rhy%2Caps%2C104&sr=8-1

X: https://twitter.com/autismgadfly

Jonathan Mitchell website http://www.jonathans-stories.com

Wikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer)

Hans Asperger called the children "little professors"- This is Autism.

In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied.

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger

0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells

2:29 B.3

5:15 Hans Asperger, Autist

7:19 Leo Kanner

8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell

13:50 Personal Experiences; Vietnam War; B.2 complications with B.3

15:22 Baseball Game and Probability

16:52 Adult Examples

17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships

21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning

23:36 Unusual Objects; ADHD prep; Finding interests in Life

26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism

28:53 Circumscribed

31:36 Perseverative; The Nervous System

35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus

39:16 Dogs and Snakes

39:50 Autistic Phenotype and B.3 at the Center

40:30 Reviews/Ratings and Contact Info

X: https://twitter.com/rps47586

Hopp: https://hopp.bio/fromthespectrum

email: [email protected]

In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism.

Quantum Biology https://www.patreon.com/DrJackKruse/posts

Photobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/

B9 (folate) and B12 (cobalamin) are Photoreceptors, too.

0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding

3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research

5:07 Genetic Variants, Copy Number, Duplications, Deletions

7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin

13:03 Brain Connectivity and Neurobiology

13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky

14:25 Early Diagnosis and Bio-markers

14:47 Comorbid Conditions

16:05 Personalized Interventions

16:27 Medications and the PROFIT MILL

18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF

19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up

25:17 Shift-Work Warning

26:20 Back to Autism; Amish

29:07 Reviews/Ratings, Contact Info

X: https://twitter.com/rps47586

Hopp: hopp.bio/fromthespectrum

email: [email protected]

In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.

Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.

Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496

Su study: https://www.nature.com/articles/s41564-024-01739-1

Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/

Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9

Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts

(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions

(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems

(6:22) POMC; HPA; Stress example

(8:19) Common Autism problems in the GI

(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation

(14:09) Melanin/POMC; Clock-Timing; Omentum

(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut

(19:04) Vitamin D Receptors and more Clock-Timing

(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids

(24:33) Avoiding UV Light implications

(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data

(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles

(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD

(38:27) Reviews/Ratings and Contact Info

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Facebook: https://www.facebook.com/fromthespectrum.podcast

Email: [email protected]

In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast.

Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy.

Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496

Eric Courchesne https://profiles.ucsd.edu/eric.courchesne

Prenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3Dtrue

The ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-y

Leukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdf

mTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/

Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/

0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology

5:45 Cellular processes; ASD Living Biology; becoming the complex living organism

8:17 1st Trimester: Proliferation, neurogenesis, migration

8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function

9:12 3rd Trimester: Neural networks

9:33 Epoch 1 and 2

13:04 Scientific Literature; risk-genes; send research and funding to pregnancy

17:57 Abnormal brain development in the embryo

21:39 Excitation and the risk-genes and consequences to the Nervous System

24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT

29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes

33:12 Recap on the Past 3 episodes

36:00 Reviews/Ratings and Contact Info

X: https://twitter.com/rps47586

Facebook: https://www.facebook.com/fromthespectrum.podcast

Email: [email protected]

In this episode, we explore some critical dates and understanding of Autism. We will time travel from 1911 to 2024 with a goal of understanding why the sharp increase in Autism diagnosis of late. We review the closeness of schizophrenia and the separation from schizophrenia. In addition, we will review Autism becoming a separate diagnosis in the DSMs from the 1980s and review the closeness of Vaccines and Assessment Standardization that parallels this time. Hopefully, some consideration about the rates of Autism are presented.

Top Revenue Business Types- Not good. https://www.ibisworld.com/united-states/industry-trends/biggest-industries-by-revenue/

Bayh-Dole Act https://www.govinfo.gov/content/pkg/USCODE-2011-title35/html/USCODE-2011-title35-partII-chap18.htm

How Autism became Autism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918/#bibr56-0952695113484320

Eugon Bleuler DEMENTIA PRAECOX OR THE GROUP OF SCHIZOPHRENIAS https://philpapers.org/archive/BLEDPO-2.pdf

Dr. Catherine Lord https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000659246090

(0:00) Intro, Classifications, Symptoms, Schizophrenia, DSM, Assessments, Vaccines and Bayh-Dole Act

(3:21) 1911; Twilight Peaks; Psychoanalysis; Eugon Bleuler; Early Autism

(10:37) 1959- Separating from Schizophrenia; Generational Lineage; Visual Imagery; Communication Problems are noticed

(14:21) The DSM and the Development of Autism Diagnosis

(17:32) Assessments becoming Standardized

(20:22) Vaccines and the Bayh-Dole Act of 1980; Vaccine Schedule and Centralized Medicine and Revenue

(25:06) 1980s-2000 emergence of Diagnosis and Assessments; Rates of Autism and Explainations

(30:03) Reviews/Ratings and Contact Info

X https://twitter.com/rps47586

Facebook https://www.facebook.com/fromthespectrum.podcast

Email [email protected]

Autism just magically shows up.

In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.

The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics.

"... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse

(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA

Tetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMI

Tetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4

Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs

Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev

Autism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277

Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567

Regions of Interest:

Atoms,

Aromatic Amino Acids,

Artificial Light,

Chromophores,

Cytochromes,

Electromagnetic,

Embryo,

Folate Acid (and Folic Acid)

Sunlight,

Melanin (Neuromelanin),

Melanocytes,

Melanogenesis,

Melanopsin,

Mitochondria,

Neuroectoderm,

Neuroplasticity,

Periodic Elements,

Photoelectric Effect,

Pro-opiomelanocortin (POMC)

Proteins (wide-band gap semiconductors),

Serotonin,

Tryptophan Hydroxylase 1 and 2,

Vitamins A, b9 (Folate/Folic Acids), B12, and D,

Water

X: https://twitter.com/rps47586

Facebook: https://www.facebook.com/fromthespectrum.podcast

Email: [email protected]

In this episode, we discuss Autism with Dr. Leanna Hernandez. Dr. Hernandez is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and director of the Hernandez Lab. She is a member of UCLA’s Center for Autism Research and Treatment, Center for Neurobehavioral Genetics, and the Brain Research Institute, and serves as Co-Director of the Genetics, Genomics, and Informatics Core for UCLA’s Intellectual and Developmental Disabilities Research Center.

Hernandez Lab https://www.hernandezlabucla.org

Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism https://www.nature.com/articles/mp2016209

Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity https://www.nature.com/articles/s41398-020-0750-9

Oxytocin and Vasopressin and the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 https://www.youtube.com/watch?v=DAtmC-s1_e0

(0:00) Intro; Dr. Leanna Hernandez

(2:24) Autistic Phenotypes

(4:13) Dr. Hernandez education journey into Autism and the Hernandez Lab

(9:03) 2017 Paper Oxytocin Receptor Gene, Common Genetic Variance, Single Nucleotide Polymorphisms (SNP), and Reward and Social Processing and the Nucleus Accumbens (NAc)

(15:10) Differences in Brain Connectivity between Autistics and Non-Autistics

(20:06) Social Cognition, Boy Bias in Autism; GENDAAR Consortium and Sex- and Diagnosis-Differences

(21:48) GENDAAR

(22:45) Boys versus Girls Connectivity involving the NAc with and without Autism

(25:38) Different Connectivity correlated with Different ADOS scores for Repetitive Behaviors

(26:35) Female Protective Effect for Autism; Camouflaging/Masking

(30:19) The Assessment process for Girls and the Oxytocin Receptor Gene Sex Differences and Socialness and understanding the Boy Bias

(32:48) Current Research and a Genome Wide approach and Polygenic Risk Scores

(35:10) Oxytocin and Excitation/Inhibition

(37:08) Sharing Information and Current Research

(41:45) The Future of Autism Research

(45:48) Reviews/Ratings and Contact Info

email: [email protected]

X: https://twitter.com/rps47586

Facebook: https://www.facebook.com/fromthespectrum.podcast

We expand on a critical network discussed in the Autism and Adaptive Responses episode. The biology that gives us Autism, gives us a condition the outside world is chaotic. The trade off is our inner world is comfortable. See criteria B.3.

The Salience Network is used to determine what we send our attention to as we orient ourselves with the outside world. You can see this in Autism versus Non-Autism. Autistics orient to single objects or single interests more than multiple objects or interests. That's Criteria B of Autism- Restricted, Repetitive Interests, Behaviors, or Activities.

In Autism, the Salience Network connects to different regions compared to Non-Autism, and this is shown at Six-Weeks-Old. And, this implicates our Social Attention and Social Motivation. Remember Hans Aspergers called the children "little professors" because Autism provides a path of Superpowers based on those fixated interests that are "abnormal in intensity or focus."

Covered Here. Also, we prepare for another discussion with a leading scientist from UCLA.

Study on Six-Week-Old https://www.nature.com/articles/s42003-024-06016-9

GENDAAR https://pubmed.ncbi.nlm.nih.gov/34050743/

(0:00) Intro; Human's Capacity to Think; the Salience Network and the NAc

(2:56) Insula

(4:47) Defining the Salience Network and Salience Detection; getting "hijacked" and metabolic bank account

(7:42) the Biology that gives us Autism causes a Chaotic outside world

(9:00) Returning to Six-week-olds and the Salience Network

(10:28) The Prefrontal Cortex and Human Cortex quiets things so we can properly evaluate things

(13:52) Salience Connections of six-week-olds; social attention at 3-12 months; Autistic traits at 12 months

(17:40) Sex-and-Diagnosis Differences; GENDAAR study using 8-17 year olds; Salience Network and Sensorimotor and Repetitive Behaviors

(20:47) Second Key Finding and possible cause of Boys Bias with Autism

(21:30) The Nucleus Accumbens- Reward Hub; Two Parts; shell and core

(25:20) Preparing for a future episode

(30:27) Reviews/Ratings and Contact Info

Facebook https://www.facebook.com/fromthespectrum.podcast

Email: [email protected]

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.

Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/

Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/

Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue

Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284

Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis

https://pubmed.ncbi.nlm.nih.gov/33400920/

Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/

(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives

(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)

(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic

(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light

(8:58) Magnocellular and Parvocellular

(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions

(22:20) Scientific Literatures

(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing

(30:07) Oxytocin and Dopamine

(31:08) Dopamine Receptors

(31:37) GABA

(33:57) Intranasal Oxytocin

(36:08) Take aways from Intranasal Literature

(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)

email: [email protected]

In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.

Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.

Dr. Catherine Lord:

https://www.semel.ucla.edu/autism/team/catherine-lord-phd

https://childmind.org/bio/catherine-lord-phd/

https://labs.dgsom.ucla.edu/lord/pages/our_team

The Lancet Commission https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01541-5/abstract

The Lancet https://pubmed.ncbi.nlm.nih.gov/30078460/

Nature Reviews Disease Primers https://pubmed.ncbi.nlm.nih.gov/31949163/

Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638

https://music.amazon.com/podcasts/d948fecc-8cfa-4203-8493-a12d2c9c92ed/episodes/bf7ce843-0dd2-4fe8-b800-82ea9cace96d/from-the-spectrum-finding-superpowers-with-autism-autism-and-education

The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/

(0:00) Intro

(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum

(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments

(16:36) Gaps in the Autism Assessment

(23:15) The Challenges with Understanding the Spectrum of Autism

(29:32) Updates on the Lancet Commission and Profound Autism

(35:19) Barriers with Autism and the Medical Field

(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)

(44:25) The Future of Autism and Helping Autistics Across the Life Span

(51:03) Reviews/Ratings and Contact Info

email: [email protected]

In this episode, we explore three regions associated with social awareness- the medial Prefrontal Cortex, the Anterior Cingulate Cortex, and the Insula. We review the functions of each, the interactions between each region, and the inputs and bi-directional connections to some crucial areas of the brain. In large part, we will review adaptive responses and cover some scientific literature on these regions and the implications to Autism.

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00593-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354837/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766703/#:~:text=Schematic%20structure%20of%20different%20regions,and%20infralimbic%20cortex%20(IL).

https://www.cell.com/neuron/fulltext/S0896-6273(12)01108-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627312011087%3Fshowall%3Dtrue

https://www.nature.com/articles/s42003-024-06016-9

https://www.sciencedirect.com/science/article/pii/S0149763409000815?via%3Dihub#aep-section-id15

https://www.tandfonline.com/doi/full/10.1080/17470919.2023.2242095

https://www.sciencedirect.com/science/article/abs/pii/S0006322308011578

(0:00) Intro; mPFC, ACC, and Insula

(3:26) mPFC, Excitation / Inhibition; CNTNAP2, SHANK3, Neuroligin, and PTEN

(7:42) Functions of mPFC and a primary dive into Adaptive Responses; Neuromodulators

(13:52) ACC

(15:23) the mPFC and ACC lead the way

(19:29) Scientific Studies on Theory of Mind Task and Sensory Processing

(21:52) Insula

(26:49) Scientific Study: Eye Gaze, Social Attention, Social Cognition, Observational Learning

(30:11) Social and Nonsocial Studies- different areas for Autistics versus Non-Autistic

(32:38) A study using 6-week-old Infants, attentional biases and sensorimotor and different brain areas

(35:05) Wrap Up

email: [email protected]

In this episode, we discuss biology of anxiety, responses from anxiety, and common situations causing anxiety with Autism. The stress response system of the body is very finite and the nervous system reflexively responds based on what it knows. A few biological components of anxiety include the amygdala, bed nucleus of the stria terminalis (BNST), and the spine. Common responses to anxiety include avoidance, shifts in physiology, and valance, or how we feel about the situation. To end, we have a lengthy discussion on some common sources of anxiety.

Biology and Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690364/

Deisseroth on Anxiety https://www.youtube.com/watch?v=UtCeIefq_PM

Deisseroth on Autism and Anxiety https://www.youtube.com/watch?v=4oiKOX2lCmE

Physiological Sighs https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00474-8

Jack Feldman https://bioscience.ucla.edu/people/jack-feldman/

David Spiegel https://med.stanford.edu/profiles/david-spiegel

Joseph LeDoux https://as.nyu.edu/faculty/joseph-e-ledoux.html

(0:00) Intro; Comorbid Tendency and the DSM

(2:56) Anxiety's role

(3:42) Biology and responses of Anxiety; Amygdala and Bed Nucleus of the Stria Terminalis; Avoidance, Physiology, Valance

(7:48) Avoidance (Action)- Hypothalamus

(9:11) Brief notes on Cortex

(11:36) Back to the Hypothalamus

(12:27) Physiology/Breathing (Body)- Parabrachial Nucleus; Physiological Sigh; Brainstem, Spine, and Body

(17:48) Valance (Feelings)- Ventral Tegmental Area; direct or indirect exposure- it doesn't matter

(20:00) Dopamine, Neuroplasticity, Side note on Testosterone, Multiple words have the same meaning

(24:58) Common situations for Anxiety and Autism

(35:58) Wrap Up, Reviews and Ratings, Contact Info

In this episode, we cover Autism and employment- some Superpowers and some Superdeficits. We discuss different types of work that are easier and fit our abilities and cover some challenges in the workplace. Some challenges include the social dynamic and being misunderstood, which are driving forces and sources of burnout and avoidance. Remember the metabolic "bank" account and the Excitation/Inhibition discussion.

Brain Science and Sir Simon Baron-Cohen https://www.youtube.com/watch?v=gMxfq_QLuUU

Brain Science Podcast https://www.youtube.com/@BrainSciencePodcast

Pattern Seekers by Sir Simon Baron-Cohen https://www.amazon.com/Pattern-Seekers-Autism-Drives-Invention/dp/1541647149

Autistic Brain by Temple Grandin https://www.amazon.com/Autistic-Brain-Temple-Grandin/dp/0544227735

(0:00) Intro; Clip of Sir Simon Baron-Cohen on Brain Science with Dr. Ginger Campbell; Society's trap and time perception

(6:20) Autism and awareness; Do others see or understand our abilities

(9:12) The applying process and the interview- we hate look at me; Superdeficits are easier to remember; Honesty and accuracy and Employers don't have an accurate comparison

(12:39) Understanding the Autistic Brain

(14:25) Autistic Traits - some Superpowers

(21:20) Autistic Traits - some Superdeficits

(28:43) Good and Bad: Perfectionism- a tough balance

(30:42) Do things that you can do, you will do, and you love to do; The Nervous System just does; See Temple Grandin and Sir Simon Baron-Cohen on types of employment for different types of Autistic Brains

(31:38) Reviews and Ratings; Contact Information

In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction.

Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030).

Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618

Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/

Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html

Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s

(0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment

(7:00) The Prescription Era; Medication first Paradigm

(10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning;

(13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not?

(13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism;

(14:39) Subject Switching and Criteria B conflict

(17:14) If you have met one child with Autism, you have met one child with Autism

(17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience;

(23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics;

(27:00) Art was fine, other subjects were not fine; Details to General versus General to Details;

(27:58) High School personal experiences; Pathway to Success > General Education;

(29:52) Did I graduate, or Not?

(31:56) SAT

(32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses)

(36:34) Education Arrangement; Taking Notes is challenging

(39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information

There is no question Mothers that have children with Autism are incredible. You are loved and appreciated.

Criteria B is Autism. Hans Aspergers called the children with the syndrome "little professors." This is Autism. Our routines and fixated interests. Autism gives us the ability to be comfortable within ourselves, and this accelerates our abilities, our Superpowers. How will society handle these so-called "differences" and the conflict within the so-called "normal" people?

In this episode, we expand to real-life examples of Criteria B components and review some personal experiences.

Dopamine Nation (Pleasure and Pain SeeSaw) https://www.annalembke.com

https://www.templegrandin.com/templegrandinbooks.html

(0:00) Intro; Autism is Criteria B, how will society handle "differences," those differences create conflict in others, stimulus-response, conflict, and comfort

(4:44) Routines (B2) and Plans, Exact Planning, Plan versus Actual Time and Execution, Reality meets our Visualized Thinking; Pleasure and Pain SeeSaw; More Relationship Struggles Implicated by Criteria B,

(9:01) Punctual- for others and ourselves; Bias yourself into Action; Understanding the need for Breaks; Others take the easy way out; get Sunlight for our Biology

(12:34) Personal Experience and a Glimpse into an Autistic Thought; Traffic Spacing

(16:33) Researching Items and Fixated Interests (B3); personal experience; Hans Aspergers and his Little Professors- This is Autism!

(20:40) Other examples- Pant Sizes and Alpha instead of Numerical, Restaurant Rant, Never Underestimate a Human's Capacity to Think; Don't try to change Autism because it is offends you- offends your expectations and beliefs

(23:12) Reviews and Ratings and Contact Information

Don't try to change an Autistic Person because they are "different" than you.

In this episode, we explore more examples of Criteria A- Deficits in Social Communication and Interaction. Yay, more DSM-5-TR. Can you fit in, or not? Are you like the so-called "normal" people, or not? This episode is highlighted by personal experiences and examples. Plus, I have three jokes. The examples and episode is not exhaustive, however, I try to capture some of the conditions on the spectrum. There are lots of examples in our social world that just does not make sense, and we like to say, "that does not make sense."

See Jack Kruse, Quantum Engineering 45

(0:00) Introduction; Crude Symptoms intend to capture the Spectrum; Can you fit in, or not? Are you like the so-called normal people, or not?

(2:08) Facts and Reality over Make-Believe; Methodical and Seeing Bottlenecks in Society- I hate "that's just the way it is"; Traffic; Names- Landon?, Associations; Repeating things- I hate, "like I said."

(7:09) "This does not make Sense"; Romantic Interests and Joke 1; Verbal Responses; Task-Switching from Fixated Interests; Sound Blends

(11:44) Social Media Use- Strange; Eye-Contact- Humans say we need to do it, and We are not Birds; Leaving Social Gatherings and Joke 2, the gathering will gather without me

(15:32) High-Fives = Stereotypy?; I hate Favors- favors create conflict; Henry David Thoreau; Self-Checkout Lanes and Autism, Neuroplasticity and Preference; Emotional Empathy

(20:04) Debriefing and Understanding; Supplementing Relationships and Visual Thinking; Joke 3 and Fixated Interests and Perfect Intensity- the DSM can have it's "abnormal" label; Echolalia; Fitting In and Modeling as a Blueprint

(26:03) Wrap-Up; Don't try to change an Autistic Person because They are "different" than you; Contact Information

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.

Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.

https://www.nature.com/articles/s41398-023-02317-5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/

https://www.nature.com/articles/s41398-018-0155-1

https://www.nature.com/articles/nature10360

https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmed

https://www.nature.com/articles/s41380-022-01506-w

(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena

(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum

(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation

(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical

(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I

(22:25) Wrap-up and understanding Autism, and Contact Info

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.

See Dr. Jack Kruse Quantum Engineering 45

Email: [email protected]

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary.

Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdf

PTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue

16p11.2, Serotonin, and Possible Social Deficit Rescues

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/

https://www.nature.com/articles/s41586-018-0416-4

https://www.nature.com/articles/s41386-021-01091-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/

Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/

Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/

SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3

Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/

https://www.sciencedirect.com/science/article/pii/S0092867414006734

(0:00) Introduction; Excitation and Inhibition;

(3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should?

(10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;

(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;

(19:24) Back to 16p11.2 and Cortical Development;

(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;

(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;

(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC

(29:25) Wrap Up and Contact Information

email: [email protected]

In today's episode, we discuss Criteria A in the DSM-5-TR, which involves social communication and interaction. We discuss various aspects of the social world including unpredictableness, sensory processing being overwhelmed from the rapid firehose of information, being a student in a classroom, empathy, and are Autistic's being changed instead of cultivated into their own unique gifts (or Superpowers).

Autism and Empathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484273/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804307/

More from CNTNAP-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/

https://www.cell.com/fulltext/S0092-8674(11)01010-5

Sir Simon Baron-Cohen https://www.psychol.cam.ac.uk/people/simon-baron-cohen

Temple Grandin https://www.templegrandin.com

Deisseroth on Socialness https://www.youtube.com/watch?v=gOWnf1BpkGs

DSM (don't get hitched on this book) https://www.psychiatry.org/psychiatrists/practice/dsm

(0:00) Introduction;

(2:12) A1; don't change others just because; joining conversation; unpredictableness, protection, sensory processing and sounds blending; firehose of information;

(15:11) A2; don't change others just because pt. 2 and ABA therapy; interests are easier for all; challenges in the classroom and mental effort;

(21:09) A3; challenges with play as a child; strict rule adherence; imaginative play, even when good, is bad; fits and tantrums; speech and peers; empathy- emotional versus cognitive- ASD is better at emotional empathy; supplementing relationships later in life with small talk; relationships are hard!

(31:32) Leo Kanner correction- Nervous Child, not Pathology- Pathology section in Nervous Child;

(31:54) Final Thoughts; contact information and reaching out to me

Email- [email protected]

In this episode, we discuss criteria B from the DSM-5-TR. Criteria B are known as Restricted and Repetitive Behaviors. In addition, we discuss how criteria B implicates criteria A, or the social communication and interaction aspects of Autism.

Projections https://www.amazon.com/Projections-Story-Human-Emotions/dp/B08LDWC2L6/ref=sr_1_4?crid=1GPPI5ZOFM2OS&dib=eyJ2IjoiMSJ9.nkY0ZQ0_m001QwcD7GiPwEwRdZitzaWU2NDjvRw_-xiCyiXLlyVfEZSzmonDa2coKQXiPSas9JLw1NeXBBjVh-I5pYHXvMVnLvB9vFwniO7QRoSLMGL3Idst8j8oqskuyPjy1UlNxZR23U_Ch22UJLU033T0wsMJNyZE6FcDepX8XAZAlXqeWXAHRXYD6jhVQLF771sNzRg3o_tKPJBoDr7GF0TWaaX5Nl7Mynmvvc4.Yfa8m249WY_xvl2E3TGObX7BoDhrJ_nU9R8d0ezWL34&dib_tag=se&keywords=projections&qid=1711134807&sprefix=projections%2Caps%2C100&sr=8-4

Peter Attia and Karl Deisseroth https://youtu.be/4oiKOX2lCmE?si=Ru7W7cPpDDxtE8Qr

Future Treatment possibilities https://youtu.be/eeySrgKev2g?si=IbX5h6qG5ddBPeO5

Leo Kanner https://psycnet.apa.org/record/1943-03624-001

Meet My Autistic Brain Episode https://podcasts.apple.com/us/podcast/meet-my-autistic-brain/id1548001224?i=1000629007371

APA's DSM-5-TR https://www.psychiatry.org/psychiatrists/practice/dsm

(But don't get hitch on this book)

Time Scales

Introduction (0:00)

A Brief History (1:29)

Similar Disorders (or Phenomena) (2:25)

Levels of Autism; Criteria A and B; Superpowers and Superdeficits (5:16)

Criteria B; B1 Stereotyped or Repetitive Motor Movements, Use of Objects, or Speech; Stimming; Echolalia Example (9:40)

B2 Insistence on Sameness, Inflexible Adherence to Routines, or Ritualized Patterns of Verbal or Non-Verbal Behavior; Rigid Thinking Patterns and Gray Areas cause Problems; BEE MOVIE example (16:24)

B3 Highly Restricted, Fixated Interests that are "Abnormal" in Intensity or Focus; Find your Interests and Superpowers and Do That; Vietnam War; Memorization, Accelerated Learning and Personal Example (22:37)

B4 Hyper or Hyperactivity to Sensory Input or Unusual Interests in Sensory Aspects of the Environment; Complications with Eye-Contact and Keeping Up; Sensory Processing Phenomena; Visualization and the Eyes (32:47)