The Human Upgrade with Dave Asprey

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! 

In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there! 

What You’ll Learn: 

• How to naturally boost oxytocin for better relationships and emotional health 

• The fastest way to upgrade your cold plunge for heat shock benefits 

• Is rapamycin really a longevity miracle? Dave’s personal take 

• How mitochondria impact brain power, mood, and aging—and how to fix them today! 

• The shocking reason some people can’t process reality correctly (and how to retrain your brain) 

• The real truth about stem cells, exosomes, and V-cells for regeneration 

• The hidden dangers of selenium, thyroid supplements, and over-fasting 

SPONSORS 

-Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  

-Calroy | Head to https://calroy.com/dave for an exclusive discount. 

Resources:  

• Upgrade Collective Membership: https://www.ourupgradecollective.com 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Intro 

• 00:37 – Welcome to the Human Upgrade AMA 

• 01:13 – Cold Plunges and Alpha Lipoic Acid for Health 

• 03:11 – Hot and Cold Therapy for Optimal Health 

• 07:29 – Understanding Thyroid Health and Treatment 

• 09:09 – The Importance of Selenium 

• 14:41 – Stem Cells vs. Exosomes 

• 16:27 – Rapamycin for Longevity 

• 18:07 – Asperger’s Syndrome and Neuroinflammation 

• 28:53 – Understanding Asperger’s and Self-Awareness 

• 29:24 – The Challenge of Offering Help 

• 30:06 – The Importance of Reconnection Work 

• 31:34 – Personal Development Journey 

• 34:42 – The Role of Emotions in Biohacking 

• 35:55 – Dealing with Flashbacks and Trauma 

• 45:46 – The Power of Oxytocin 

• 49:48 – The Truth About Kale and Oxalates 

• 54:25 – Teaching Kids to Regulate Their Nervous System 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can You Mimic Fasting—Without Actually Fasting? 

Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. 

Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. 

Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. 

For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. 

What You’ll Learn: 

• The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours) 

• The four fasting metabolites that extend life by 96% 

• How Mimio mimics fasting benefits—without giving up food 

• The real reason over-fasting destroys your metabolism and hormones 

• Why traditional longevity drugs (Metformin, Rapamycin) fall short 

• Can you build muscle and burn fat at the same time? The science of mTOR & AMPK 

• Why Big Pharma doesn’t want you to know about this breakthrough 

*** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** 

Sponsors:

Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Mimio Instagram:  https://www.instagram.com/mimiohealth/ 

• Mimio Website:  https://mimiohealth.com/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Intro 

• 00:58 – Fasting & Longevity 

• 01:88 – Optimal Fasting Length 

• 03:39 – Alternate Day Fasting: Pros & Cons 

• 05:50 – Key Fasting Compounds 

• 07:34 – Spermidine & Longevity Molecules 

• 11:41 – FDA Roadblocks on Natural Compounds 

• 15:37 – AI, Big Data & Longevity Research 

• 31:19 – Mimio’s Impact on Testosterone & Aging 

• 35:16 – Longevity & Death Philosophy 

• 36:48 – Biohacking Origins 

• 37:03 – Metabolism & Cognitive Function 

• 38:35 – Unexpected Effects of Fasting 

• 40:43 – Fasting & Circadian Rhythms 

• 43:09 – Mimio Science & Benefits 

• 45:14 – Mimio in a Daily Routine 

• 55:05 – Men vs. Women: Fasting Differences 

• 01:02:23 – Future of Nutrition & Biohacking 

• 01:07:21 – Conclusion & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Could a single molecule be the difference between vibrant longevity and early decline? 

Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. 

This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? 

Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. 

Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer. 

What You’ll Learn: 

• The #1 reason your NAD is disappearing—and how to fix it 

• Why NAD is the missing link in energy, DNA repair, and disease prevention 

• The hidden enzyme (CD38) that’s sabotaging your longevity 

• How to supercharge mitochondria, optimize blood flow, and fight aging at the source 

• Why the supplement industry has it wrong—and the best way to boost NAD naturally 

• The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Wonderfeel Instagram –  https://www.instagram.com/getwonderfeel/  

•  Wonderfeel Supplement :  https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

01:07 Introduction and Episode Overview 

02:29 Meet Dr. Andrew Salzman 

02:36 From Physician to Researcher 

03:39 Pharmaceuticals vs. Nutritionals 

04:17 The Role of NAD in Longevity 

06:32 Challenges in Longevity Research 

12:58 Understanding NAD and PARP 

14:34 NAD’s Impact on Health 

23:19 Gut Health and Longevity 

27:43 Innovations in NAD Supplementation 

41:27 Customer Feedback and Product Effectiveness 

42:41 Surprising Benefits of NAD for Sexual Health 

44:47 NAD and Vascular Health 

48:46 NAD’s Role in Aging and Longevity 

54:03 NAD and Lifestyle Choices 

01:03:02 NAD and Cognitive Function 

01:06:18 NAD and Exercise 

01:13:42 NAD and Sleep 

01:21:54 Final Thoughts on NAD and Longevity 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to the metabolism masterclass!

Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. 

From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. 

What You’ll Learn: 

• The #1 driver of insulin resistance—and why most doctors miss it 

• Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction 

• How fasting, cold therapy, and red light impact your metabolism 

• The truth about carbs, seed oils, and why some people can’t gain fat 

• How to tell if insulin resistance is wrecking your energy & health 

 Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

•  Benjamin’s new book How Not To Get Sick :  https://a.co/d/aADlMWv 

• Benjamin’s YouTube Page –  https://www.youtube.com/@benbikman 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

00:00 Trailer 

00:52 Introduction to Dr. Benjamin Bikman 

02:20 The Battle Against Conventional Dietetics 

04:12 Understanding Insulin Resistance 

06:29 The Two Paths to Insulin Resistance 

10:19 Fasting and Metabolic Health 

14:11 Insulin and Cognitive Enhancement 

18:16 Identifying Insulin Resistance 

30:12 The Role of Insulin in Fat Storage 

42:04 Understanding Glucose and Insulin Dynamics 

42:26 The Role of Exercise in Glucose Regulation 

42:54 AMPK and Muscle Contraction 

45:21 Calories In, Calories Out Debate 

46:15 The Myth of Calorie Counting 

50:13 Ketosis and Metabolic Rate 

51:14 Intermittent Fasting and Muscle Preservation 

55:21 Insulin Resistance and Ketogenic Diets 

01:02:04 Circadian Rhythm and Insulin Sensitivity 

01:08:08 Environmental Toxins and Insulin Resistance 

01:13:03 The Impact of Seed Oils on Insulin Resistance 

01:19:22 Final Thoughts and Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people wait for inspiration. But what if you could train your brain to create on demand? 

Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? 

In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. 

Dave and Rick go deep on the mental and physiological hacks that enhance creative performance, the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. 

What You’ll Learn: 

• How Rick Rubin taps into creative flow—and how you can too 

• The surprising connection between meditation and peak artistic performance 

• Why biohacking isn’t just for longevity—it’s for creative mastery 

• Rick’s favorite tools for mental clarity, focus, and creative breakthroughs 

• The real secret behind working with the world’s biggest artists 

• How to cultivate an environment that fuels creativity 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS   

• Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off.  

BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. 

Timestamps: 

• 00:00 – Trailer 

• 00:51 – Intro to Rick Rubin 

• 02:51 – Rick’s Musical Journey 

• 03:06 – The Creative Process 

• 08:31 – Biohacking & Sensitivity 

• 13:46 – Meditation & Creativity 

• 19:37 – Rick’s Weight Loss Story 

• 29:21 – Eating Habits & Rhythm 

• 29:55 – Advanced Biohacking 

• 31:23 – Oxygen Therapy & Carbogen 

• 35:16 – Peptides & Longevity 

• 45:59 – Prayer, Gratitude & Performance 

• 51:03 – Reflections on Life & Mortality 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? 

Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. 

Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity, this episode will shift the way you think about money, health, and success. 

Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through? 

What You’ll Learn: 

• The biggest mistake people make with money (and how to avoid it) 

• The mindset of the ultra-wealthy—how top investors think differently 

• Why fear is your greatest enemy in investing and personal success 

• The three essential money buckets—security, growth, and dreams 

• Tony’s top biohacks for insane energy and peak performance 

• The real secret to happiness and fulfillment (it’s not what you think) 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Tony’s Website: https://www.tonyrobbins.com/ 

• Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Timestamps: 

• 00:00 Intro 

• 00:50 Meet Tony Robbins 

• 02:18 Financial Wisdom & Motivation 

• 05:43 Psychology of Wealth 

• 10:10 Investment Strategies 

• 15:24 Balancing Money & Experiences 

• 21:21 Power of Giving 

• 30:06 Paying for College 

• 31:00 Commitment & Success 

• 31:53 Energy & Biohacks 

• 35:12 Cryotherapy & Inflammation 

• 38:54 Stem Cells & Regeneration 

• 41:59 Financial Freedom 

• 46:35 Wnt Pathway Breakthroughs 

• 52:35 Health & Longevity 

• 56:34 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? 

In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of quick fixes, and the hard truths about personal transformation. 

Timbaland opens up about the mental shift that saved his life, how he kicked a high-dose opioid habit cold turkey, and why his new “drug” of choice is something anyone can access. 

Most people want change, but few actually achieve it. What separates those who succeed from those who stay stuck? And how can you apply Timbaland’s hard-earned lessons to your own life? 

What You’ll Learn: 

• The #1 mindset shift that made weight loss & addiction recovery possible 

• Why self-discipline beats willpower—and how to build it like a muscle 

• The real reason most diets fail—and what actually works 

• The truth about opioid addiction and recovery—why most people never escape 

• How your daily habits shape your future—and how to change them fast 

• The shocking link between addiction, metabolism & long-term health 

• How Timbaland stayed clean without rehab—and why relapse wasn’t an option 

We’d like to extend our gratitude to Eudēmonia for providing the opportunity to record with Timbaland at their event. Eudēmonia, created by the founders of Wanderlust Festival, is a premier health and well-being summit. You can learn more about their initiatives and upcoming events here: https://wanderlust.com/ 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Timbaland’s Website: https://www.timbaland.com/ 

• Timbaland’s Instagram : https://www.instagram.com/timbaland/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order.  

-Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. 

Timestamps: 

• 00:00 Trailer 

• 00:00 Introduction to the Human Upgrade 

• 00:09 Timbaland on Passion and Energy 

• 00:42 Balancing Passion and Avoiding Burnout 

• 02:04 Dreams and Manifestations 

• 04:51 Overcoming Addiction 

• 05:59 The Role of God in Recovery 

• 09:28 Helping Others with Addiction 

• 14:00 Weight Loss and Health Transformation 

• 16:29 Trusting Your Body’s Signals 

• 18:45 Skepticism About Modern Products 

• 21:10 Exploring Longevity and Individual Health 

• 22:23 The Intersection of Music and Spirituality 

• 25:56 Understanding Synesthesia and Its Impact 

• 27:41 The Journey to Weight Loss and Fitness 

• 35:08 The Importance of Sleep and Health 

• 37:23 Final Thoughts and Reflections 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Could the right form of a single vitamin be the difference between thriving and barely surviving? 

In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. 

Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn’t talking about this critical health breakthrough. 

Are you unknowingly setting yourself up for disease? What’s the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity? 

What You’ll Learn: 

• The MTHFR gene mutation—and why it’s quietly affecting millions 

• Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain 

• The gut-brain connection—how your microbiome controls your mood 

• Why your “healthy diet” might be hurting you (and what to eat instead) 

• How nutrient deficiencies are passed from mother to child—and how to stop it 

• The truth about homocysteine—the blood marker that could predict your lifespan 

• Why most people are living at 50% capacity—and how to get your energy back 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Gary Brecka’s Website: https://bit.ly/4hlfyti 

• Gary Brecka’s YouTube: https://bit.ly/3E3Aaba 

• Gary Brecka’s Instagram: https://bit.ly/3PNsgFe 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

• The Mold Movie!: https://moldymovie.com/ 

SPONSORS:  

-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.  

-Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. 

Timestamps: 

• 00:00 Trailer 

• 00:31 What Is Methylation? 

• 01:37 MTHFR, Folate & Your Health 

• 04:17 How Methylation Affects Disease 

• 06:41 Nutrient Deficiencies & Health Risks 

• 07:09 Why Blood Work Matters 

• 11:44 Homocysteine & Heart Health 

• 21:37 Catecholamines & Anxiety 

• 34:28 The Link Between Nutrients & Mood 

• 34:48 How Catecholamine Ratios Affect Mental Health 

• 35:39 Personal Health Struggles & Lessons 

• 36:25 The Role of Methylation in Wellness 

• 37:57 Methylation & Relationship Dynamics 

• 39:49 Hidden Dangers of Mold Toxicity 

• 52:55 Hydrogen Water for Health 

• 01:01:19 Mitochondria’s Role in Longevity 

• 01:02:23 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? 

Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the corporate greed, medical corruption, and environmental toxins designed to keep you sick, weak, and dependent. 

What’s really causing the testosterone collapse in men and women? How is AI changing the game for hormone optimization, biohacking, and personalized health? And why are we aging faster than ever—while Big Pharma profits? 

This first episode in a two-part series is a deep dive into hormone optimization, testosterone, cholesterol myths, longevity hacks, and the AI-driven future of health.  

What You’ll Learn: 

• Why testosterone levels are plummeting—and how to restore them naturally 

• The real reason life expectancy is dropping (hint: it’s not just diet) 

• The Kellogg conspiracy—how food was designed to lower libido & testosterone 

• Why mainstream medicine is failing you (and what to do instead) 

• How AI and big data are rewriting the rules of health & longevity in

• The shocking truth about cholesterol, heart disease, and pharmaceuticals 

• Why functional medicine & biohacking hold the key to real health optimization 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Gary Brecka’s Website: https://bit.ly/4hlfyti 

• Gary Brecka’s YouTube: https://bit.ly/3E3Aaba 

• Gary Brecka’s Instagram: https://bit.ly/3PNsgFe 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. 

Timestamps: 

• 00:00 – Trailer 

• 00:42 – Introduction to The Human Upgrade 

• 01:35 – Meet Gary Brecka 

• 03:32 – Performance vs. Longevity 

• 06:16 – The Importance of Testosterone 

• 15:11 – Historical Hormone Levels 

• 18:00 – Population Averages in Health 

• 18:51 – The Flaws of Grading on a Curve 

• 20:35 – Corporate Influence on Health 

• 21:04 – The Danger of Cumulative Dosage 

• 22:20 – Social Media & Public Perception 

• 25:19 – Independent Research Matters 

• 32:21 – Big Data & AI in Health 

• 36:02 – The Future of Personalized Medicine 

• 36:49 – Conclusion & Teaser for Part Two 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, and reality. What if the Great Pyramid wasn’t just a monument but a powerful energy device designed to amplify human potential? What if ancient civilizations understood frequency, grounding, and longevity in ways modern science is only beginning to grasp? 

In this episode, the Carsons connect the dots between lost technology, bioenergetics, and conscious relationships, showing how these ancient systems align with the latest research on vibrational healing, mitochondrial energy, and peak performance. They explore how quantum fields influence cellular regeneration, why high-frequency living affects health and relationships, and how suppressed knowledge could redefine the future of wellness. 

What You’ll Learn: 

• How the Great Pyramid functioned as an energy generator—and how to apply its principles to longevity 

• The forgotten science of frequency and its effects on health, aging, and vitality 

• How quantum energy and grounding can optimize mitochondrial function 

• The connection between biohacking, consciousness, and relationships 

• Why suppressed ancient knowledge holds the key to true human potential 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• 4biddenknowledge YouTube – https://www.youtube.com/@ForbiddenKnowledge1 

• 4biddenknowledge Website – https://www.4biddenknowledge.com/ 

• Billy Carson Instagram – https://www.instagram.com/4biddenknowledge/?hl=en 

• Elisabeth Carson Instagram - https://www.instagram.com/elisabethicarson/?hl=en 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Timestamps: 

• 00:00 Trailer 

• 00:39 Meet Dave Asprey 

• 02:16 Trauma, Success & Relationships 

• 04:22 Billy & Elizabeth Carson on Growth 

• 10:09 Birth & Pre-Natal Trauma 

• 19:30 Healing & Biohacking 

• 23:16 Relationships & Triggers 

• 28:35 Vitamin D & Nutrients 

• 35:25 Empathy & Intuition 

• 37:24 Manifestation 

• 41:25 Neuroscience & Altered States 

• 53:04 Ancient Wisdom & Biohacking 

• 57:45 Ancient Technologies 

• 01:08:26 Giants & Six Fingers 

• 01:08:58 Sumerian Artifacts 

• 01:10:28 Hidden Agendas 

• 01:13:32 Hypnosis Revelations 

• 01:19:21 Power of Intuition 

• 01:30:11 Love & Self-Discovery 

• 01:35:52 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Everything you’ve been told about weight loss is a lie!

In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health. 

Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional dieting often fails—and what actually works. From the role of ketosis in healing chronic illness to the surprising ways fasting affects hair loss, metabolism, and inflammation, this episode is packed with actionable insights that you won’t hear anywhere else. 

You’ll also learn how viruses might be fueling food addiction, why gut health is the missing key to metabolic recovery, and how new research could unlock the future of personalized medicine. If you’ve ever felt like your metabolism was holding you back, this conversation will give you the tools to take control of your health for good. 

What You’ll Learn: 

• Why calorie counting is useless—and the better way to lose weight 

• The shocking truth about how your metabolism ACTUALLY works 

• How ketosis and fasting can heal inflammation and chronic disease 

• The role of gut health and microbiome diversity in weight loss 

• New research on food addiction and its surprising link to viruses 

• Why individualization is the key to sustainable health 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Nick Norwitz’s YouTube – https://www.youtube.com/@nicknorwitzPhD 

• Nick Norwitz’s Website – https://www.nicknorwitz.com/ 

• Follow Nick on Instagram – https://www.instagram.com/nicknorwitz/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

• Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Timestamps: 

• 00:00 Trailer 

• 00:39 Meet Dr. Nick 

• 04:44 Nick’s Health Journey 

• 07:54 Keto Diets 

• 09:37 Modern Medicine Challenges 

• 13:31 Exercise vs. Diet 

• 14:32 Obesity Memory 

• 17:36 Keto Cycling 

• 20:51 Microbiome Health 

• 26:26 Fasting & Hair Loss 

• 34:56 Alzheimer’s Insights 

• 45:11 Cold Plunge Benefits 

• 45:43 Dopamine Boosts 

• 46:26 Cold Plunge & Inflammation 

• 47:15 Best Time to Cold Plunge 

• 48:18 Pain & Dopamine 

• 49:31 Exercise & Stress 

• 51:49 Cholesterol & Inflammation 

• 01:05:42 Debunking Calories In/Out 

• 01:07:09 Food Addiction 

• 01:11:15 Metabolic Health Tips 

• 01:24:13 Nick’s Mission 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the key to living longer isn’t avoiding stress—but mastering it 

Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancient practices that have stood the test of time, Jeff shares how to unlock the hidden potential of stress to build resilience, foster connections, and boost longevity. 

You’ll discover why crying is an emotional biohack, how to spot the fine line between good and bad stress, and why the modern world keeps us stuck in a chronic stress loop—and how to break free. Jeff also dives into the science of emotional regulation, the role of connection in health, and the radical power of embracing discomfort to create balance and ease in your life. 

What You’ll Learn: 

• How to turn stress into a tool for resilience and longevity 

• Why Jeff calls chronic ease the root of modern disease 

• The science of tears: how crying regulates stress and boosts health 

• How you can build a “psychological immune system” for emotional regulation 

• The key to balancing good stress and avoiding burnout 

• Why discomfort is the path to growth—and how to embrace it 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Jeff Krasno’s Website – https://www.jeffkrasno.com/ 

• Preorder Good Stress – https://www.onecommune.com/goodstressbook#preorder 

• Follow Jeff on Instagram – https://www.instagram.com/jeffkrasno 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

• Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. 

• Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 

Timestamps: 

• 00:00 – Intro 

• 01:02 – Meet Jeff Krasno 

• 02:16 – Topanga Fires Survival 

• 04:14 – Good Stress vs. Bad Stress 

• 06:14 – Cortisol’s Role in Stress 

• 13:13 – Social Media Triggers 

• 20:32 – Stressful Conversations 

• 31:34 – Cold Therapy Benefits 

• 42:26 – Stress and Recovery Balance 

• 45:58 – High Altitude Training 

• 47:29 – Cold Therapy Fails 

• 49:42 – Science of Crying 

• 54:51 – Reflections on Legacy 

• 59:37 – Balancing Stress and Ease 

• 01:10:30 – Nature and Spirituality 

• 01:22:52 – Facing Death with Grace 

• 01:32:53 – Closing Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? 

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. 

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level. 

What You’ll Learn: 

• The Seven Tenets of Aging and how they’ll change your approach to health 

• Why indulging in “bad” habits doesn’t have to sabotage your longevity 

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk 

• The real story behind NAD, circadian rhythms, and the tools for better sleep 

• How to create a personalized health plan that’s sustainable, effective—and fun 

Resources:  

• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Kaufmann Protocol Website: https://kaufmannprotocol.com 

• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047 

• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 SPONSORS:  

Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. 

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

• 00:00 Trailer 

• 00:45 Guest Introduction 

• 02:30 Longevity Insights 

• 04:22 Personal Stories 

• 08:00 Pharmaceuticals 

• 12:26 Diet and Lifestyle 

• 18:19 Seven Tenets 

• 22:04 Sleep and Circadian Rhythms 

• 26:41 NAD and Supplements 

• 37:46 Blood Sugar and AGEs 

• 47:09 Microcirculation 

• 49:08 NRS and Imports 

• 49:18 Celebrex Medication 

• 50:03 Celebrex Benefits 

• 50:41 Alzheimer’s and Celebrex 

• 51:28 Antioxidants 

• 54:26 Stem Cells and Exosomes 

• 58:03 Laser Skin Treatments 

• 01:07:34 Hormones and Longevity 

• 01:20:03 Lithium for Mood 

• 01:27:45 Gender and Longevity 

• 01:32:39 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is there actual “magic” on this planet, or is it just in the movies? 

Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life. 

From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry reveals the extraordinary power of the “Great 8” — a framework to unlock your potential in relationships, creativity, health, intelligence, and more. This episode is packed with incredible stories, actionable wisdom, and a secret GIFT to help you start your own journey toward unparalleled vitality and longevity! 

What You’ll Learn: 

• The 8 ancient secrets to mastering energy, healing, and peak performance 

• How you can harness quantum physics for success 

• Why energy techniques can REVERSE aging and boost health naturally 

• The science of serendipity and how you can harness it daily 

• How to grow stronger, smarter, and healthier every day with simple practices 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Follow Dr. Barry on Instagram: https://www.instagram.com/energyforsuccess.official?igsh=eGcwZWhid3Q1M2Rm&utm_source=qr

• Explore the Great 8 and Get Your Free Gift: https://energyforsuccess.com/dave/ 

• Learn More About Energy Practices: https://energyforsuccess.com/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 SPONSORS:  

- Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

- Calroy | Head to https://calroy.com/dave for an exclusive discount. 

Timestamps: 

• 00:00 Trailer 

• 01:10 Introduction to Dr. Barry and His Journey 

• 06:16 The Turning Point: Mrs. Rodriguez’s Story 

• 09:04 Exploring Alternative Medicine Around the World 

• 13:02 Discovering Ancient Chinese Healing Techniques 

• 16:39 The Power of Quantum Physics and Lao Tzu’s Teachings 

• 27:25 Personal Experiences with Energy Healing 

• 36:35 The Great Eight: Structuring Your Day for Success 

• 36:51 Introduction to Energy for Success 

• 37:17 Understanding the Great Eight 

• 38:23 The Matrix and Animal Brain 

• 44:39 The Importance of Serendipity 

• 49:35 Four Categories of People 

• 53:02 Personal Experiences and Lessons 

• 58:34 The Power of Energy Practices 

• 01:07:06 Conclusion and Call to Action 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What happens when nearly 60 years of combined biohacking expertise collide in one podcast? 

Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier.

They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical routines you can start today. Peter, the author of The Longevity Guidebook, shares deeply meaningful tools and tips to expand your healthspan for decades to come. 

What You’ll Learn: 

• The top AI tools reshaping health and longevity 

• Simple daily habits that improve energy, sleep, and brain performance 

• Why mindset is the key to adding years to your life 

• The cutting-edge science of age reversal and functional health 

• How Peter and Dave biohack their routines for peak performance 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Peter Diamandis’s New Book: https://longevityguidebook.com/home-blk-nav 

• Peter Diamandis’s Website: https://www.diamandis.com/ 

• Peter Diamandis’s Purpose Finder (MTP): https://purposefinder.ai/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. 

-LMNT | Free LMNT Sample Pack with any drink mix purchase by going to drinklmnt.com/dave. 

Timestamps: 

• 00:00 Open 

• 00:53 Introduction to Peter Diamandis 

• 01:54 Peter’s Longevity Journey 

• 03:26 Tracking Sleep and Biohacking 

• 05:49 The Importance of Deep Sleep 

• 07:22 Thinking Big and Longevity 

• 10:36 Russian Innovations in Sleep 

• 25:29 AI and Longevity 

• 29:01 Gene Editing and Epigenetics 

• 35:13 Light Therapy and Routines 

• 43:07 Gut Health and Endotoxins 

• 44:17 Exploring Conscious Pain Practices 

• 45:51 Hacking Hot Tubs for Health Benefits 

• 46:28 The Science Behind Dopamine Reset 

• 46:43 Introduction to Fountain Life 

• 48:41 Advanced Diagnostics and AI Integration 

• 50:29 Therapeutics and Cutting-Edge Treatments 

• 51:41 The Evolution of Longevity Companies 

• 55:30 The Future of Longevity and Healthspan 

• 01:01:27 The Role of AI in Health and Longevity 

• 01:07:31 Personal Longevity Practices and Insights 

• 01:16:43 Finding Your Purpose for Longevity 

• 01:24:01 Final Thoughts and Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? 

In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health. 

Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision training, and how anyone can rewire their brain for sharper sight. If you’re dealing with nearsightedness, eye strain, or just want to keep your eyes sharp as you age, this episode shares simple ways to improve how you see the world—literally! 

What You’ll Learn: 

• Why vision training is the next frontier in biohacking 

• Three free techniques to improve your vision naturally 

• How your eyesight affects brain performance and energy levels 

• Why kids and adults need to get outside for better eye health 

• How to train your eyes to stop relying on glasses 

Go to www.screenfit.com/enroll and use code DAVE ($200 OFF with the code) 

Or 

Visit myvisionfirst.com/dave/ for 5000$ off the premium concierge program! 

Sponsors

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Screenfit- Visit https://www.screenfit.com/enroll and use code DAVE ($200 OFF with the code, from $497 to $297) 

• MyVisionFirst – Visit https://myvisionfirst.com/dave/ and apply now to get $5000 off 

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Timestamps: 

• 00:00 Intro 

• 00:29 Dave Asprey’s Vision Journey 

• 04:33 Understanding Vision Beyond 20/20 

• 08:01 Impact of Environment on Vision 

• 22:47 Exercises to Improve Vision 

• 27:29 Effective Eye Exercises for Better Vision 

• 27:46 Daily Routine for Eye Health 

• 29:12 Peripheral Vision Training 

• 31:15 Vision and Body Connection 

• 33:38 Handling Visual Overload 

• 35:04 Vision Training Benefits 

• 39:25 Neuroplasticity and Vision 

• 45:22 Vision Training for All Ages 

• 46:38 Practical Vision Improvement Tips 

• 54:24 Final Thoughts on Vision Training 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the secret to living to 250 was simply sitting in the garden? 

In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cells and accelerating healing. 

Christian dives into the fascinating stories behind these plants, their ancient origins, and how modern science is proving their power to extend life. He also shares how anyone—regardless of age—can tap into these natural tools to transform their health and longevity. Imagine harnessing the same methods as a Chinese healer reportedly living to 250 years old. Could these practices be the missing link to longer, healthier lives? 

What You’ll Learn: 

• The surprising plants that naturally stimulate stem cells 

• How stem cells repair and rejuvenate your body from the inside out 

• Why fasting can reset your cellular health 

• Practical tips to harness your body’s natural ability to heal 

• The secrets to improving recovery, energy, and longevity 

Resources:  

• 2025 Biohacking Conference - STEMREGEN is the Title Sponsor – https://biohackingconference.com/2025 

• STEMREGEN Website - Visit stemregen.co/dave and save 20% on STEMREGEN! 

• Christian Drapeau’s Website - https://christiandrapeau.com  

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. 

Timestamps: 

• 00:00 Intro 

• 00:57 Meet Christian Drapeau: Stem Cell Expert 

• 02:22 Understanding the Innate Repair System 

• 04:26 Stem Cells and Aging: The Science Explained 

• 05:27 Fasting and Stem Cell Rejuvenation 

• 08:34 STEMREGEN: Activating Your Body’s Stem Cells 

• 12:09 Historical Longevity Practices 

• 17:59 Enhancing Stem Cell Function: Lifestyle Tips 

• 22:45 The Role of PEMF in Stem Cell Activation 

• 26:45 The Importance of Immediate Recovery 

• 27:22 Stem Cells and Longevity 

• 28:13 The Bank Account Analogy of Aging 

• 29:05 Stem Cells and Age-Related Diseases 

• 30:42 Mind Over Matter: The Brain’s Role in Stem Cell Release 

• 32:51 The Quantum Mechanics of Stem Cells 

• 36:22 The Role of Science in Understanding Reality 

• 42:24 Biological Clocks and Stem Cells 

• 46:08 Future of Stem Cell Research and Applications 

• 49:36 Practical Applications and Success Stories 

• 52:23 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are we protecting our kids—or unknowingly putting their health at risk? 

Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time. 

With his integrative and functional approach, Dr. Warsh unpacks the startling rise in chronic illnesses among children and questions if we’re truly asking the hard questions about vaccine safety and efficacy. This isn’t about taking sides—it’s about uncovering the truths every parent needs to know. 

Dave and Dr. Warsh dive deep into the science, the myths, and the hidden risks Big Pharma doesn’t want you to hear about. Whether you’re a parent, a skeptic, or just someone seeking the truth, this episode will give you the tools and insights to navigate this complex issue with confidence. 

What You’ll Learn: 

• The alarming rise in chronic illnesses and what might be driving it 

• Why vaccine safety studies may not tell the whole story 

• The critical questions every parent should ask before vaccinating 

• How toxins in our environment are impacting our kids’ health 

• Practical steps to protect your children in today’s world 

 Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Dr. Joel “Gator” Warsh’s Book: Parenting at Your Child’s Pace – https://www.amazon.com/Parenting-Your-Childs-Pace-Pediatricians/dp/1454952490 

• Dr. Joel “Gator” Warsh’s Website – https://www.integrativepediatrics.com 

• Dr. Joel “Gator” Warsh on Instagram – https://www.instagram.com/drjoelgator 

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. 

-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%. 

Timestamps: 

• 00:00 Intro 

• 00:40 Personal Health Journey and Pediatric Concerns 

• 01:41 Interview with Dr. Joel Gator Warsh 

• 02:49 Rising Chronic Diseases in Children 

• 04:03 Factors Contributing to Health Issues 

• 10:13 Debating Vaccine Safety and Efficacy 

• 30:32 Historical Context and Vaccine Research 

• 44:18 Introduction to Dr. Joe Dispenza and Meditation 

• 45:13 Genetics and Vaccine Controversies 

• 46:16 The Importance of Individualized Medicine 

• 49:02 Western Medicine’s Flaws and Alternatives 

• 50:07 Childhood Health Crisis and Solutions 

• 50:52 Pharmaceutical Industry Critique 

• 52:09 The Role of Parents and Doctors in Child Health 

• 01:04:43 The Influence of Big Pharma on Medicine 

• 01:19:56 Balancing Vaccination Decisions 

• 01:25:44 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your hearing isn’t just about sound—it’s the key to sharper focus, deeper connections, and increased awareness. In this episode, Dave explores the cutting-edge world of hearing technology with Brandon Sawalich, CEO of Starkey, and reveals how you can gain superhuman hearing with almost no effort.

“Listening” to this episode is going to be one of the best things for your hearing. But why? Because your hearing isn’t just about detecting sounds—it’s about transforming the way you experience the world. Imagine real-time translation in 75 languages, tuning out noise pollution, and amplifying what truly matters—all while protecting your brain from cognitive decline and boosting your overall performance.

Brandon shares the groundbreaking innovations that redefine what hearing devices can do. From biohacking your auditory environment to integrating AI for mood and health tracking, this conversation will change how you think about your ears, your brain, and your future.

What You’ll Gain from This Episode:

• Discover how superhuman hearing enhances focus and reduces mental fatigue

• Learn why better hearing can slow brain aging and improve mental health

• Get an inside look at AI-powered hearing technology that’s changing lives

• Understand the surprising connection between hearing and peak performance

• Find out how upgrading your hearing can unlock new opportunities for success

Sponsor: 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:

• Starkey Hearing Technologies – Explore AI-powered hearing aids and innovations: https://www.starkey.com

• Starkey Blog – Stay updated on the latest in hearing health: https://www.starkey.com/blog

•   Starkey Instagram - https://www.instagram.com/starkeyhearing/

• Danger Coffee – Clean, mold-free coffee for sustained energy: https://dangercoffee.com

• Dave Asprey’s Website – Explore biohacking tools, books, and more: https://daveasprey.com

• Dave Asprey’s Book: Smarter Not Harder – Biohacking made simple: https://daveasprey.com/books

• Dave Asprey’s Linktree – Access all Dave’s platforms: https://linktr.ee/daveasprey

• Upgrade Collective – Join live podcast recordings: https://www.ourupgradecollective.com

• Own an Upgrade Labs – Franchise opportunities for cutting-edge health labs: https://ownanupgradelabs.com

• Upgrade Labs – The ultimate biohacking experience: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback for advanced cognitive enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Introduction to Hearing Loss

• 01:23 Dave Asprey’s Personal Hearing Journey

• 02:47 Guest Introduction: Brandon Sawalich

• 03:45 Advancements in Hearing Technology

• 06:47 The Importance of Hearing for Brain Health

• 17:32 Hearing Aids as Performance Enhancers

• 25:32 Future Innovations in Hearing Technology

• 27:03 Detecting Lies with Technology

• 27:26 The Science of Sleep Enhancement

• 29:57 Innovation and Risk-Taking in Business

• 32:18 Addressing EMF Concerns with Hearing Aids

• 34:26 Ethical Considerations in Technology

• 37:06 Empowering Users with AI and Hearing Technology

• 43:38 Future of Biohacking and Hearing Superpowers

• 44:57 Conclusion and Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear. 

Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high. 

Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live. 

Why This Episode Matters: 

• You’ll discover how fear sneaks into your decisions—and how to stop it 

• Learn why courage is the ultimate skill for success and fulfillment 

• Get actionable advice to break through self-imposed limits 

• Understand the psychology of fear and how to use it as fuel 

• Hear real-life stories of people who overcame fear to achieve greatness 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Ryan Holiday’s Website – https://ryanholiday.net 

Daily Stoic Website – https://dailystoic.com/ 

Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC 

Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

-Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. 

Timestamps: 

• 00:00 – Intro 

• 00:44 – Discussing Ryan Holiday’s Work 

• 02:37 – The Concept of Courage 

• 08:09 – Fear and Courage in History 

• 12:41 – Stoic Philosophy and Modern Applications 

• 21:50 – The Four Virtues and Their Interrelation 

• 28:39 – Challenges in Admitting Mistakes 

• 35:21 – Navigating Business Risks During a Pandemic 

• 36:44 – The Essence of Courage in Business and Life 

• 37:03 – Reed Hastings and the Duality of Courage 

• 40:06 – Moral Courage: Lessons from History 

• 43:35 – The Debate on Mandates and Personal Freedom 

• 45:22 – Balancing Public Health and Individual Rights 

• 58:29 – The Role of Responsibility in Society 

• 01:09:01 – The Importance of Intellectual Courage 

• 01:12:04 – Reaching Audiences in a Noisy World 

• 01:13:27 – Final Thoughts and Encouragement 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today we are bringing back one of our all-time favorite episodes with James Altucher. 

Dave sits down with James, an entrepreneur, bestselling author, and master experimenter, to uncover why the 10,000-hour rule might just be holding you back. Instead of grinding your way to expertise, James reveals his 10,000 Experiment Rule—a game-changing approach to mastering any skill faster than you thought possible. 

From comedy stages to boardrooms, James has redefined success through relentless experimentation and bold pivots. In this electrifying conversation, he exposes the toxic allure of “failure porn” and why glorifying failure might be sabotaging your growth. You’ll learn why skipping the line isn’t just possible—it’s essential for thriving in a world obsessed with rigid rules. 

This episode dives deep into the power of curiosity, the art of experimentation, and the strategies James uses to crush the myth of conventional wisdom. Whether you’re stuck in a career rut, looking to start something new, or just want to optimize your life, James delivers unfiltered insights to help you rewrite the rules. 

What You’ll Learn: 

• Why the 10,000-hour rule is outdated—and what actually works 

• How “failure porn” is dragging you down (and how to escape it) 

• The 10,000 Experiment Rule that accelerates skill mastery 

• Bold strategies to break through limits and skip the line in any industry 

• Why curiosity is the ultimate superpower for growth and success 

• Practical steps to monetize your passion and build a life you love 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

James Altucher’s Website – https://www.jamesaltucher.com 

The James Altucher Show Podcast – https://podcasts.apple.com/us/podcast/the-james-altucher-show/id794030859 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors 

-Calroy | Head to https://calroy.com/dave for an exclusive discount. 

-Viome | Go to https://viome.com/dave to save $110 on the Full Body Intelligence Test. 

Timestamps: 

00:00 Introduction to The Human Upgrade Podcast 

00:38 Meet James Altucher: Entrepreneur and Author 

01:02 The Comedy Journey: From Advice to Stage 

02:06 The Controversial New York Article 

03:42 Facing Backlash and Public Reaction 

10:46 The 10,000 Experiment Rule 

15:44 Skipping the Line: Challenging Conventional Wisdom 

23:35 The Importance of Loving What You Do 

31:30 A Chance Encounter with Howard Schultz 

32:11 The Plus Minus Equals Technique 

33:26 Applying Techniques to Chess Mastery 

34:43 The Importance of Curiosity 

36:30 Experimenting with Comedy 

38:44 The Concept of Failure Porn 

40:39 The Hero’s Journey in Business 

44:42 Living an Experimental Life 

47:10 Frame Control in High-Stakes Situations 

53:43 Advice for Parents and Kids 

55:29 Conclusion and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can you use hate to make the world a better place?  

Daryl Davis, a world-class jazz musician, didn’t just confront hate—he dismantled it. By sitting down with over 200 Ku Klux Klan members, he inspired them to leave their robes behind. But this isn’t just a story about racism or redemption; it’s a story about the incredible power of human connection and the lessons it holds for all of us. 

In this special episode, Dave explores how Daryl turned impossible conversations into transformative breakthroughs. Together, they unpack the mindset shifts, emotional intelligence, and fearless curiosity that can break down barriers of all kinds—whether they’re rooted in bias, fear, or misunderstanding. 

Daryl’s approach to erasing hate is so unique, so impactful, that it may just change how you view conflict, compassion, and even your own health. 

What You’ll Learn: 

• How Daryl’s global upbringing shaped his fearless approach to conflict 

• Why eliminating hate starts with understanding, not opposition 

• The neuroscience of compassion and how it rewires your brain 

• How forgiveness can transform your health and happiness 

• A step-by-step framework for tackling impossible conversations 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Daryl Davis's Book: Klan-destine Relationships (Go read it for free at your local library instead of buying on Amazon :)) 

Daryl Davis's Website – https://www.daryldavis.com 

Daryl Davis on Instagram – https://www.instagram.com/realdaryldavis/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

• 00:00 A Shocking Parade Experience 

• 00:38 Meeting the KKK: First Impressions 

• 01:06 Introducing Daryl Davis 

• 03:46 Daryl’s Unique Upbringing 

• 09:52 Confronting Racism: A Lifelong Quest 

• 14:16 The Power of Travel and Perspective 

• 18:25 A High School Encounter with Nazis 

• 21:12 Confronting the Klan Leader 

• 30:57 Changing Minds: A Personal Approach 

• 36:30 The Illusion of Latent Genes 

• 42:08 Collecting Klan Robes: A Symbolic Victory 

• 46:17 Facing the Klan: Staying Grounded 

• 48:27 Challenging Beliefs: Confronting Hate 

• 49:15 The Journey to Writing ‘Clandestine’ 

• 50:26 Introducing ‘The Klan Whisperer’ 

• 51:35 Reflections on Racism and History 

• 57:29 The Power of Forgiveness 

• 59:28 Freedom of Speech and Its Limits 

• 01:02:21 Personal Stories of Racism 

• 01:13:16 Cultural Understanding and Misunderstandings 

• 01:25:16 The Impact of Music on Memory 

• 01:29:02 Final Thoughts and Upcoming Events 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is AI About to Replace Your Doctor? Or Save Your Life? 

The tools that are reshaping healthcare will redefine medicine—and your life—in ways you’ve never imagined. Will artificial intelligence and regenerative therapies like stem cells and exosomes make doctors obsolete? Or will they finally unlock the secrets to living to 180? 

In this episode, Dave sits down with Dr. Pradeep Albert, a leader in regenerative medicine and AI-driven imaging, to explore the intersection of technology, longevity, and healing.  

Dr. Albert shares groundbreaking insights on how AI is revolutionizing medical diagnostics, replacing outdated systems, and empowering patients to take control of THEIR OWN health. He also dives deep into regenerative therapies—how PRP, exosomes, and stem cells are changing the game for injuries, inflammation, and aging.  

Can AI improve patient-doctor relationships? Are doctors becoming coaches instead of gatekeepers? And most importantly, how can you leverage these tools to outlive your peers and enhance every aspect of your health? 

What You’ll Learn: 

• Why 50% of people won’t make it past 76—and how to beat the odds 

• How AI is already better than doctors at diagnosing certain conditions 

• The truth about PRP, exosomes, and stem cells—and when to use each 

• The three rules of longevity every person needs to know 

• How your mindset and epigenetics can help you live longer and healthier 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Dr. Pradeep Albert’s Book: Exosomes, PRP, and Stem Cells…Medicine – https://www.amazon.com/Exosomes-Stem-Cells-Musculoskeletal-Medicine/dp/B0C2S59S8K 

Dr. Pradeep Albert’s Book: Lifespan Decoded –https://lifespandecoded.com/ 

Dr Pradeep Albert’s Website – https://drpradeepalbert.com/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

OneSkin | Go to https://oneskin.co/ and use code ASPREY15 for 15% off your purchase. 

Timestamps: 

• 00:00 – Introduction to AI in Medicine 

• 00:36 – The Role of AI in Longevity 

• 00:51 – Meet Dr. Pradeep Alpert 

• 01:11 – AI’s Impact on Healthcare 

• 02:07 – Changing Role of Doctors 

• 05:01 – AI in Medical Imaging 

• 06:37 – Orthopedics and AI 

• 09:19 – Longevity and Epigenetics 

• 14:16 – The Importance of Mindset 

• 29:08 – Trust in the Medical System 

• 43:18 – DIY Health and Longevity 

• 44:21 – The Future of Insurance and Medical Costs 

• 45:45 – Advancements in Imaging Technology 

• 47:26 – The Art of Physical Examination 

• 50:21 – Regenerative Medicine: PRP, Exosomes, and Stem Cells 

• 01:00:23 – Challenges in the US Medical System 

• 01:07:54 – The Role of AI in Medicine 

• 01:18:14 – Final Thoughts and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people don’t think about their liver until it’s too late. 

In this episode, Dave sits down with Siggi Clavien, founder of de-liver-ance® & The Liver Clinic, to uncover the hidden superpowers of the body’s most underrated organ: the liver. This is a deep dive into why your liver is the ultimate game-changer for your energy, brain power, and longevity. 

Siggi reveals groundbreaking insights on reversing fatty liver disease, boosting detoxification, and harnessing the liver’s regenerative capabilities. From fighting brain fog to protecting against toxins, this episode will have you rethinking everything about how you treat your body. And yes, your liver could be the key to living a healthier, happier life. 

Siggi also shares the science and innovation behind de-liver-ance®, his groundbreaking herbal product designed to deliver the most powerful results in a safe, natural way. Backed by millions of dollars and years of research, de-liver-ance® is setting a new standard in liver health. 

Use code: DAVE at https://us.loveyourliver.com/discount/DAVE to get a discount! 

Dave and Siggi also explore cutting-edge strategies to supercharge your liver health using natural herbs, breakthrough science, and biohacking tools. 

What You’ll Learn: 

• Why your liver holds the key to longevity, energy, and mental clarity 

• How to reverse fatty liver disease—even if you’ve been told it’s irreversible 

• The truth about common liver-destroying habits you need to ditch now 

• Groundbreaking ways to protect and regenerate your liver for optimal health 

• The science behind de-liver-ance® and how it’s changing liver health forever 

• Simple, actionable strategies to boost detoxification and supercharge your body 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

de-liver-ance® – https://us.loveyourliver.com/discount/DAVE (Use code DAVE at checkout for a discount!) 

The Liver Clinic – https://theliverclinic.com 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Timestamps: 

• 00:00 Intro 

• 00:00 Introduction and Liver Basics 

• 01:46 Guest Introduction and Liver Health Insights 

• 02:16 Understanding Liver Scans and Lab Panels 

• 05:13 Fatty Liver Disease: Causes and Consequences 

• 07:07 Diet and Liver Health 

• 09:47 Supplements and Liver Function 

• 11:53 Advanced Liver Health Strategies 

• 14:05 Biohacking and Liver Health 

• 17:41 Deliverance Supplement and Its Benefits 

• 23:12 Liver Health and Longevity 

• 31:12 Biohacking: The Path to Consciousness and Longevity 

• 32:29 The Liver: The Body’s Regenerative Powerhouse 

• 34:48 Gut Microbiome and Liver Health Connection 

• 35:59 Lipopolysaccharides: The Hidden Toxins 

• 40:44 Coffee: A Surprising Ally for Liver Health 

• 43:16 Mold Toxins: The Silent Liver Destroyers 

• 48:43 Hormone Health and the Liver 

• 52:19 Type 2 Diabetes, Menopause, and Liver Health 

• 52:43 The Impact of Lifestyle on Liver Health 

• 54:57 The Importance of Bile and Gallbladder Health 

• 58:06 Genetics, Toxins, and Liver Resilience 

• 01:06:25 Conclusion: Investing in Liver Health for a Better Life 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Will the next nuclear bomb be AI Superintelligence? 

The intelligence we’re building will reshape the world in ways we never imagined—for better or worse? But more importantly, what side will humanity take? 

In this episode, Mo Gawdat, bestselling author of Scary Smart and former Chief Business Officer of Google X, joins Dave to tackle the profound challenges and opportunities artificial intelligence presents. This isn’t about dystopian robots or tech hype—it’s about redefining what it means to be human in the age of machines. There’s hope, don’t worry!  

Mo dives into the reality of how AI is already shaping our behavior, our ethics, and even our potential for happiness. He reveals the critical need for aligning intelligence—human or artificial—with values that promote global abundance and collaboration. Dave and Mo mix data, philosophy, and bold visions, to show why our future depends on shifting from competition to cooperation. But most importantly, why all of this is going to make you a better YOU. 

What You’ll Learn: 

• The real reason AI is reshaping human behavior—and how to take back control 

• Why intelligence without ethics could lead to catastrophe 

• How abundance thinking can unlock limitless possibilities for humanity 

• The crucial mindset shifts leaders need to adopt before it’s too late 

• Practical insights for ensuring AI supports human flourishing, not destruction 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Mo Gawdat’s Book: Scary Smart – https://a.co/d/6DukqyW 

Mo Gawdat’s Book: Unstressable – https://a.co/d/hrbpY9O 

Follow Mo Gawdat on Instagram – https://www.instagram.com/mo_gawdat/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  

- fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Timestamps: 

• 00:00 The Ethical Dilemma of AI in Warfare 

• 00:31 Introduction to Part Two with Mo Gawdat 

• 00:58 AI and Human Happiness: A Complex Relationship 

• 03:18 The Power and Responsibility of Technology 

• 05:08 The Rise of AI and Its Impact on Society 

• 08:31 The Future of AI: Abundance or Destruction? 

• 19:53 The Role of Ethics in AI Development 

• 22:39 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can Happiness Really Be Engineered? Mo Gawdat Says Yes—And Here’s How.  

I know what you’re thinking… ANOTHER episode on happiness? Haven’t we heard it all before? This one’s different. The code is cracked, and you’re about to learn exactly how it works. 

Joining us today is Mo Gawdat, bestselling author of Unstressable and former Chief Business Officer of Google X. Mo sits down with Dave to deliver a practical, science-backed approach to hacking your mind and body for lasting joy. 

Mo dives into the raw science behind happiness and stress—revealing how your brain runs on algorithms that you can actually reprogram. Discover why dopamine might be sabotaging your joy, how to decode the four types of stress, and biohacks that can flip the script on your mental and physical resilience. 

He also shares the deeply personal story of how he turned unimaginable tragedy into a global mission for happiness and purpose. Mo’s insights will challenge everything you thought you knew about living a fulfilled life. 

What You’ll Learn: 

• The happiness algorithm—and how to make it work for you 

• Why dopamine addiction is robbing you of joy (and how to fix it) 

• The four stress modalities and how to regain control 

• Biohacks that build resilience—like cold plunges, gratitude, and micro-habits 

• How small mindset shifts can create major life transformations 

And don’t miss Part 2, dropping in two days! Dave and Mo explore the intersection of happiness and AI, revealing how to get them both working FOR you instead of against you. 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Mo Gawdat’s Book: Scary Smart – https://a.co/d/6DukqyW 

Mo Gawdat’s Book: Unstressable – https://a.co/d/hrbpY9O 

Follow Mo Gawdat on Instagram – https://www.instagram.com/mo_gawdat/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

Neurohacker | Go to https://qualialife.com/dave and use code Dave for 15% off. 

Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

Timestamps: 

00:00 – Intro 

00:31 – Introduction to The Human Upgrade 

00:45 – Dave Asprey’s AI Background 

01:13 – Introducing Mo Gawdat and His Work 

01:51 – From Scary Smart to Unstressable 

02:40 – The Journey to Happiness 

13:10 – Understanding Stress and Its Mechanisms 

17:26 – The Four Modalities of Stress 

24:16 – Mental Stress and the Happiness Flowchart 

31:34 – Sources of Stress: Trauma, Obsessions, Noise, and Nuisances 

33:27 – Understanding Modern PTSD 

34:09 – The Role of Obsessions and Noise 

36:24 – Biohacking for Resilience 

37:58 – The Power of Gratitude 

40:12 – The Happiness Equation 

54:37 – Dopamine vs. Serotonin 

01:03:00 – The Benefits of Cold Therapy 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?  

Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity. 

They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter. 

What you’ll learn: 

• Why metabolic flexibility matters more than strict diet rules 

• The science behind long-term ketosis and insulin’s broader role in health 

• How common “health foods” could be doing more harm than good 

• The importance of nutrient-dense animal-based foods for gut and immune health 

• How to achieve optimal balance between fat types, mTOR, and longevity markers 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Shop Paul Saladino’s Products – https://heartandsoil.co 

Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/ 

Paul Saladino’s Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X 

Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow 

Danger Coffee – https://dangercoffee.com 

Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

- Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

- LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave. 

Timestamps: 

• 00:00 Intro 

• 00:40 Paul Saladino’s Evolution in Diet 

• 01:21 Challenges of a Strict Carnivore Diet 

• 03:36 Reintroducing Carbohydrates 

• 05:32 Debunking Common Diet Myths 

• 13:49 The Problem with Calorie Restriction 

• 18:30 The Importance of Food Quality 

• 24:08 The Veganism Debate 

• 34:15 The Benefits of Organ Meats 

• 37:27 Foot Surgery and Bone Density 

• 39:23 Mineral Deficiency and Plant-Based Diets 

• 40:00 The Truth About Seed Oils 

• 41:10 Historical Studies on Seed Oils 

• 47:26 Mechanisms and Effects of Seed Oils 

• 52:33 Nicotine and Neuroprotection 

• 54:12 Oleic Acid and Longevity 

• 01:01:44 The Benefits of Animal Fats

• 01:02:32 Odd Chain Fatty Acids and Health 

• 01:11:07 Cheese and Dairy Considerations 

• 01:13:11 The Impact of Cheese on Health 

• 01:14:03 Protein Intake and Longevity 

• 01:14:54 Understanding mTOR and Its Effects 

• 01:17:35 Ideal Body Fat and Metabolic Health 

• 01:24:38 The Role of Omega Fatty Acids 

• 01:32:46 ApoB, Insulin Sensitivity, and Longevity 

• 01:43:09 Final Thoughts and Product Recommendations 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What are the oral hygiene tips that could save your life?  

Dave Asprey sits down with one of the most popular guests on the show, Naveen Jain, founder and CEO of Viome Life Sciences, to explore how your oral microbiome influences not just your dental health but your entire body. Naveen reveals groundbreaking insights into how imbalances in oral bacteria can trigger chronic inflammation, heart disease, and even cancer—and how understanding your unique microbiome can help prevent these risks. 

Discover why oral health goes far beyond brushing and flossing, how to optimize your oral microbiome for longevity, and why common mouthwashes may be doing more harm than good. Naveen also introduces cutting-edge solutions from Viome, including personalized oral lozenges and postbiotics, to elevate both your oral and overall health. 

In this episode, you’ll also uncover the exact foods to eat and avoid to live a longer, healthier, and more vibrant life. 

What you’ll learn in this episode: 

• The surprising link between your oral microbiome and chronic disease 

• Why bacterial diversity in your mouth is essential for overall health 

• How leaky gums drive systemic inflammation and increase health risks 

• The dangers of over-sterilizing your mouth and eliminating beneficial bacteria 

• Personalized solutions to improve oral and gut health with Viome 

• Actionable tips to optimize your oral microbiome for better longevity 

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Viome Full Body Intelligence Test (Save $110) – https://www.viome.com/dave 

• Viome Instagram – https://www.instagram.com/viome 

• Learn More About Viome – https://viome.com 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Sponsors: 

-Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. 

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Timestamps: 

• 00:00 Introduction to Viome and Its Impact on Health 

• 00:53 Meet Naveen Jain: Visionary Behind Viome 

• 02:41 Understanding the Microbiome and Its Role in Health 

• 05:54 The Power of RNA Analysis in Personalized Health 

• 12:19 Diet, Microbiome, and Personalized Nutrition 

• 29:50 The Importance of Oral and Gut Health 

• 39:20 Debating the Benefits of Intermittent Fasting 

• 40:08 The Role of Gut Bacteria in Fasting and Diet 

• 42:12 Understanding Chronic Inflammation and Diet 

• 44:13 The Keto Diet Myths and Realities 

• 45:44 Oxalates and Superfoods What You Need to Know 

• 49:25 The Concept of Holobiont and Human Health 

• 56:21 The Five Pillars of Longevity 

• 01:02:04 The Importance of Quality Sleep 

• 01:05:18 Purpose and Community for a Longer Life 

• 01:09:48 Upcoming Topics and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is this the missing link in fertility? 

The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform women’s health outcomes. 

Priyanka shares how Evvy is advancing women’s health through cutting-edge genomic research and AI-powered insights, offering solutions to challenges like bacterial vaginosis, yeast infections, recurrent UTIs, and even infertility. You’ll learn why this critical microbiome plays such a vital role, how hormonal changes and lifestyle impact it, and how personalized approaches can improve reproductive and overall health. 

This episode explores not just women’s health but also how understanding the vaginal microbiome can influence relationships, biohacking, and even groundbreaking fertility research. Don’t miss this deep dive into the science and solutions shaping the future of health. 

Here’s what you’ll learn in this episode: 

• The critical role the vaginal microbiome plays in women’s health and fertility 

• How hormonal changes affect vaginal health and microbiome balance 

• The link between vaginal microbiome imbalances and conditions like bacterial vaginosis, yeast infections, and UTIs 

• Evvy’s innovative approach to using AI and genomics for personalized health insights 

• Practical tips for maintaining microbiome health, including probiotics, hydration, and hormone balance 

• The connection between the vaginal microbiome and overall quality of life 

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Shop at Evvy (Use coupon code DAVE for $10 off!) – https://shareasale.com/r.cfm?b=1862577&u=2810239&m=116251&urllink=&afftrack=

• Follow Evvy on Instagram – https://www.instagram.com/evvy 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Sponsors: 

- Calroy | Head to https://calroy.com/dave for an exclusive discount. 

Timestamps: 

• 00:00 Trailer 

• 00:35 Introduction to Vaginal Microbiome 

• 01:12 Meet Priyanka Jain of Evvy 

• 02:03 Understanding the Vaginal Microbiome 

• 04:37 Challenges in Women’s Health 

• 09:55 Impact of Lifestyle on Vaginal Health 

• 11:22 The Role of Diet and Supplements 

• 15:24 Sexual Health and Vaginal Microbiome 

• 27:25 Menopause and Vaginal Health 

• 31:23 Optimizing Vaginal Health 

• 39:31 Exploring Women’s Health Data 

• 41:17 The Role of Vaginal Microbiome in Fertility 

• 43:44 Affordable Testing and Discount Offers 

• 45:31 The Impact of Lubricants on Vaginal Health 

• 46:20 Innovative Ideas for Probiotic Products 

• 47:29 Audience Questions and Precision Medicine 

• 48:04 The Importance of Data in Women’s Health 

• 54:31 Marketing and Misinformation in Vaginal Health 

• 01:06:34 The Connection Between Diet and Vaginal Health 

• 01:12:49 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is alcohol losing its grip as the go-to social drink? 

Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and mental clarity. 

In this episode, Dave Asprey welcomes Cameron George, founder of TRU KAVA, to discuss why kava is becoming the drink of choice for those seeking a healthier, more connected lifestyle. Learn how kava impacts neurotransmitters like GABA and dopamine, enhances creativity and emotional grounding, and even helps the body recover from stress and trauma. Discover why kava is taking center stage in the biohacking and sober-curious movements as a new tool for wellness and connection. 

Here’s what you’ll learn in this episode: 

• Why 41% of Americans and 61% of Gen Z are drinking less alcohol 

• What kava is, how it works, and its history as a ceremonial and social beverage 

• The science behind kava’s calming and neuroprotective effects 

• How kava supports creativity, emotional resilience, and authentic social connection 

• Practical uses for kava, including stress relief, sleep enhancement, and travel recovery 

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• TRU KAVA – https://www.trukava.com 

• TRU KAVA Instagram – https://www.instagram.com/trukava 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Sponsors: 

-Quantum Upgrade |Go to https://quantumupgrade.io/Dave for a free trial. 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

• 00:00 Intro 

• 00:37 Introduction to Alcohol Trends 

• 01:57 Meet Cameron George and TRU KAVA 

• 02:29 What is Kava? 

• 05:03 Kava’s Effects on the Brain 

• 06:53 Kava vs. Alcohol 

• 08:54 Active Compounds in Kava 

• 10:10 Kava’s Safety and Standardization 

• 16:17 Kava in Social Settings 

• 21:28 Kava and Psychedelics 

• 31:26 Kava for Public Speaking and Anxiety 

• 34:04 Kava in the Workplace: Enhancing Team Creativity 

• 35:22 Kava and Libido: The Unexpected Benefits 

• 36:06 Biohacking with Kava: Energy Allocation and Community 

• 39:00 Kava’s Role in Meditation and Emotional Awareness 

• 42:04 Kava During Pregnancy: Safety and Traditions 

• 44:37 Kava’s Neuroprotective Properties: A Deep Dive 

• 45:49 Kava and EMF Sensitivity: A Surprising Connection 

• 48:39 Kava for Frequent Travelers: Enhancing Mitochondrial Health 

• 52:46 Kava and Metabolic Health: Fasting and Fat Burning 

• 57:14 Kava Products: Oils, Beverages, and Their Uses 

• 01:01:27 The Future of Kava: Social Impact and Cultural Integration 

• 01:05:28 Conclusion: The Potential of Kava in Modern Society 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Have we finally discovered the key to youthful energy, longevity, and cellular health? 

In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the groundbreaking science behind Urolithin A, a revolutionary postbiotic that boosts mitochondrial function, enhances immune system resilience, and combats chronic inflammation. 

This episode goes beyond cutting-edge science. Dr. Singh reveals practical, real-world strategies to combat “inflammaging”—the chronic, low-grade inflammation that accelerates aging. Learn how fasting, gut health, and mitochondrial boosters like Urolithin A can rejuvenate your cells, fight fatigue, and supercharge your energy, vitality, and longevity. 

Here’s what you’ll learn in this episode: 

• What Urolithin A is and its role in mitochondrial health and cellular energy production 

• How to reverse “inflammaging” and reduce inflammation through nutrition, fasting, and biohacking 

• The connection between mitochondrial dysfunction and immune system aging 

• Real-life benefits of Urolithin A for energy levels, athletic recovery, skin health, and longevity 

• Why mitochondrial support is critical for combating aging and improving overall performance 

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025  

• Timeline Nutrition -  https://www.timeline.com/dave to get 10% off your first order  

• Timeline Instagram – https://www.instagram.com/timeline_longevity/  

• Dave Asprey’s Website – https://daveasprey.com  

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  

• Danger Coffee – https://dangercoffee.com  

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey  

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  

• Own an Upgrade Labs – https://ownanupgradelabs.com  

• Upgrade Labs – https://upgradelabs.com  

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com  

Timestamps: 

• 00:00 Introduction to Longevity and Mitochondria 

• 01:28 The Role of Mitochondria in Immune Health 

• 03:36 Understanding Inflammaging and Immune Aging 

• 07:47 Measuring Immune Health and Inflammation 

• 13:33 Urolithin A: A Mitochondrial Booster 

• 16:46 Dosage and Effects of Urolithin A 

• 26:11 Urolithin A and Exercise Performance 

• 28:31 Urolithin A for Skin Health 

• 31:34 Collagen and Aging: The Role of MMPs 

• 33:27 Personal Experience with MMPs and Recovery 

• 35:04 Measuring MMPs and Their Impact on Longevity 

• 36:18 Skin Health and Urolithin A 

• 38:39 Exploring Urolithin A’s Broader Benefits 

• 40:33 Brain Health and Urolithin A 

• 43:33 Combining Supplements for Optimal Health 

• 45:54 Omega-3s and Mitochondrial Health 

• 46:51 Ketones, MCTs, and Urolithin A 

• 54:30 Final Thoughts on MitoPure and Supplementation 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are exosomes the planet’s ultimate healing tool?! 

In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing, explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of stem cells. 

BUT this episode isn’t just about cutting-edge science. Dr. Park also shares profound insights into life, resilience, and emotional well-being, offering advice that goes far beyond medicine. From the power of forgiveness to breaking free of limiting beliefs, his perspective blends science, spirituality, and practical wisdom for living a better life. 

Here’s what you’ll learn in this episode: 

• How exosomes work and why they’re being called the future of regenerative medicine 

• The key differences between exosomes and stem cells—and which is better for healing 

• Real-life applications of exosome therapy for injuries, anti-aging, and overall health 

• The potential of exosomes to enhance brain function, reduce inflammation, and promote recovery 

• Dr. Park’s advice on emotional resilience, gratitude, and creating lasting change 

With over a decade of experience, Dr. Park shares compelling case studies, cutting-edge insights, and practical advice for anyone looking to upgrade their body, mind, and life. Whether you’re managing chronic pain, exploring anti-aging therapies, or seeking wisdom for navigating life’s challenges, this episode has something for everyone. 

Sponsors 

TRU KAVA | Go to https://trukava.com and enter code DAVE15 at checkout for 15% off 

Resources: 

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Dr. Edward Park’s Website: Recharge Biomedical – https://www.rechargebiomedical.com 

• Dr. Edward Park’s Book: Exosomes: Songs of Healing – https://www.amazon.com/EXOSOMES-Songs-Healing-Ed-Park/dp/098260632X 

• Dr. Edward Park’s YouTube Channel – https://www.youtube.com/channel/UCpp9DlRArB1rKAWNwoouiTg 

• Dr. Edward Park on Instagram – https://www.instagram.com/dredpark/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com  

Timestamps: 

• 00:00 Introduction to Exosomes and Healing 

• 00:48 Understanding Exosomes: Stem Cell Communication 

• 01:19 Dr. Edward Park’s Insights on Exosomes 

• 02:47 Exosomes vs. Traditional Treatments 

• 04:44 Exosomes in Regenerative Medicine 

• 07:33 Cost-Effective Regeneration Protocols 

• 12:35 Exosomes for Hair Growth 

• 14:37 Stem Cells and Brain Health 

• 25:33 Banking Stem Cells for Future Use 

• 35:27 Epigenetic Age and Longevity Predictors 

• 37:48 CRISPR and Gene Editing: Risks and Benefits 

• 39:43 Basic Health Tips for Longevity 

• 41:02 Spirituality, Past Lives, and Healing 

• 42:50 Questioning Medical and Political Narratives 

• 47:54 The Importance of Free Speech 

• 01:07:40 The Role of Intuition in Medicine 

• 01:09:22 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is biohacking your sweat the secret to vitality? 

Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level. 

Here’s what you’ll learn in this episode: 

• Why infrared saunas excel at detoxing heavy metals and toxins 

• How they mimic exercise to boost cardiovascular health and recovery 

• The science behind infrared’s impact on mitochondrial energy and longevity 

• Surprising benefits for gut health, inflammation, and hormone balance 

• Hacks to get the most out of your infrared sauna sessions 

Connie shares cutting-edge research and personal insights, offering practical ways to integrate infrared therapy into your routine. Whether you’re looking to recover faster, improve your mood, or support long-term health, this episode delivers the tools you need to take your biohacking game to the next level. 

Special Offer: Use code “DAVE” at sunlighten.com to get up to $1,000 off until December 6th! 

Sponsors:

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Resources: 

• Sunlighten Saunas Website – https://www.sunlighten.com/dave/?utm_source=DaveAsprey&utm_medium=Partner&utm_content=Podcast&leadsource=DaveAsprey&utm_campaign=DaveAsprey 

• Sunlighten Saunas on Instagram – https://www.instagram.com/sunlightensaunas/ 

   • 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Timestamps  

• 00:00 Introduction to Infrared Saunas 

• 00:27 Meet Connie Zack: Leading Voice in Infrared Saunas 

• 00:50 The Science Behind Infrared Saunas 

• 02:35 Infrared Saunas vs. Traditional Saunas 

• 05:41 Health Benefits of Infrared Saunas 

• 08:14 Technological Advancements in Infrared Saunas 

• 17:36 The Role of LEDs in Infrared Saunas 

• 22:37 Practical Tips and Personal Experiences 

• 28:14 Detoxing and Energizing with Glutathione 

• 28:40 Pre and Post-Sauna Rituals 

• 29:05 Habit Stacking in the Sauna 

• 29:41 Managing Overheating Devices 

• 31:05 Creative Breakthroughs in the Sauna 

• 32:14 Scientific Method and Personal Experience 

• 36:05 Understanding Glucose Spikes 

• 38:44 Longevity Benefits of Infrared Saunas 

• 43:27 Infrared Saunas and Skin Health 

• 45:29 Extreme Detox Protocols 

• 48:28 Grip Strength and Longevity 

• 50:34 Customizing Your Sauna Experience 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could command any room and set boundaries without saying a word? 

Dave Asprey sits down with Kasia Urbaniak, founder and CEO of The Academy—a trailblazing school where women learn the true principles of influence and authority. Kasia brings a unique and dynamic perspective, drawing on nearly two decades of experience that includes working as a professional Dominatrix, practicing Taoist alchemy in one of China’s oldest female-led monasteries, and earning certifications across disciplines like Medical Qi Gong and Systemic Constellations. 

Here’s what you’ll learn in this episode: 

• How to set clear, unbreakable boundaries in any situation 

• Techniques for wielding influence without sacrificing integrity 

• Tools to reclaim inner authority and navigate life with confidence 

• Practical strategies for handling power dynamics in relationships, work, and beyond 

Kasia’s methods have empowered over 4,000 women worldwide to step into leadership roles in every sphere, from personal relationships to professional arenas. In this episode, she shares practical insights on transforming how you’re perceived by others and, more importantly, how you perceive yourself. Whether you’re navigating complex workplace dynamics, strengthening personal boundaries, or seeking clarity in relationships, Kasia’s teachings offer a path to reclaiming the powerful, authentic authority within you. 

Sponsors 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  

-LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave. 

Resources: 

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Kasia Urbaniak’s Website – https://www.kasiaurbaniak.com 

• Kasia Urbaniak’s Book: Unbound: A Woman’s Guide to Power – https://www.kasiaurbaniak.com/unbound 

• The Academy – Practical Training for Women on Power and Influence – https://www.kasiaurbaniak.com/the-academy 

• Kasia Urbaniak on Instagram – https://www.instagram.com/kasiaurbaniak/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Timestamps: 

• 00:00 Introduction to the Human Upgrade 

• 01:07 Meet Kasia Urbaniak: Author of Unbound 

• 02:52 Exploring Power Dynamics 

• 04:46 The Role of Emotions in Power 

• 14:50 Embodiment and Somatic Work 

• 32:58 The Power of Voice and Presence 

• 48:22 Collective Intelligence and Intuition 

• 54:50 Facing Fears and Intuition 

• 55:15 Male vs. Female Intuition 

• 56:01 The Power of Erotic Energy 

• 57:13 Welcoming Emotions and States 

• 59:10 Role-Playing and Personas 

• 01:00:06 Teaching Women to Speak Up 

• 01:02:04 Energetic Dynamics in Relationships 

• 01:04:35 Victimhood and Healing 

• 01:19:54 The Power of Asking 

• 01:29:40 Money and Emotional Alchemy 

• 01:31:53 Shameless Money Conversations 

• 01:44:00 Final Thoughts and Upcoming Events 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is unlocking the full potential of your brain even possible, or just a myth from the movie Limitless? 

In this eye-opening episode, neuroscientist and author Dr. Mithu Storoni joins Dave to dive deep into the science of brain optimization for hyper-efficient work performance. Together, they break down the surprising roles of astrocytes in supporting neurons, the influence of the brain’s “blue dot” region (the locus coeruleus) on focus and mental clarity, and how harnessing neuroplasticity can lead to improved cognitive efficiency and resilience in high-stress environments. 

Get ready to discover actionable science-backed hacks for enhancing work productivity and maintaining focus—even in the face of constant distractions. Dr. Storoni also explains how optimizing your breathing rhythm, managing your brain’s arousal state, and tapping into the natural flow of ultradian rhythms can dramatically improve your mental output. 

Whether you’re looking to elevate your workflow, supercharge your mental performance, or unlock the science of hyper-efficiency, this episode delivers essential strategies to cultivate a high-performing mind for work and beyond. Tune in to understand how the latest neuroscience can transform how you think, focus, and excel every day. 

Sponsors 

-Quantum Upgrade | Go to Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 

Resources: 

• Dr. Mithu Storoni’s Website – https://www.mithustoroni.com 

• Hyper Efficient: Optimize Your Brain to Transform the Way You Work by Dr. Mithu Storoni – https://www.hachettebookgroup.com/titles/mithu-storoni/hyperefficient/9780316566933/ 

• Dr. Mithu Storoni on Facebook – https://www.facebook.com/drmithustoroni/ 

• Dr. Mithu Storoni’s LinkedIn – https://www.linkedin.com/in/mithu-storoni-0488872a/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Timestamps 

• 00:00 – Introduction to Brain Complexity 

• 00:29 – The Human Upgrade with Dave Asprey 

• 01:42 – Meet Dr. Mijtu Storoni 

• 02:16 – Understanding Brain Efficiency 

• 02:57 – The Role of Astrocytes 

• 04:37 – Brain Adaptability and Environment 

• 06:55 – Biohacking and Environmental Signals 

• 08:34 – Power vs. Efficiency Debate 

• 11:26 – The Importance of Glial Cells 

• 18:10 – The Brain as a Predictive Machine 

• 23:14 – Nutrition and Brain Health 

• 32:33 – The Gut-Brain Connection 

• 36:36 – Eye Health as a Proxy for Brain Health 

• 40:47 – Aligning the Brain: The Blue Dot Network 

• 41:54 – Understanding Brain Gears and Stress Management 

• 42:27 – Maintaining the Goldilocks Zone for Optimal Brain Function 

• 43:09 – The Role of Creativity and Daydreaming 

• 44:28 – Strategies to Stay in Optimal Mental States 

• 47:44 – Biohacking for Enhanced Efficiency 

• 51:00 – The Science Behind Flow States 

• 57:09 – Harnessing Innate Curiosity for Mental Efficiency 

• 01:03:46 – Breathing Techniques for Mental Regulation 

• 01:13:32 – The Importance of Ultradian Rhythms 

• 01:17:40 – Practical Tips for Efficient Breaks 

• 01:21:20 – Conclusion: Embracing Hyper Efficiency 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the keys to an extraordinary life lie in choices most people wouldn’t dare to make? 

In this iconic, unearthed episode, best-selling author and performance pioneer Tim Ferriss joins Dave Asprey to spill the unfiltered truth on smart drugs, insect protein, and the surprising links between sex, creativity, and high performance. 

They dig into cutting-edge topics still sparking curiosity today: the calculated risks and rewards of smart drugs, the future-forward benefits of insect protein, and how unconventional habits fuel creativity and peak performance. Tim candidly shares his personal protocols, from routine blood testing to strategic supplementation, all rooted in his philosophy that “the dose makes the poison.” 

As a powerful wrap-up, Tim lays out his top three life principles for real success: choosing high-caliber people, focusing on those who “get it,” and setting audacious, even wild, goals. Whether you’re biohacking or simply intrigued, this episode delivers timeless insights and bold ideas for anyone ready to unlock a high-performance life. 

Sponsors 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

-Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. 

Resources: 

• Tim Ferriss’ Website – https://tim.blog 

• Tim Ferriss’ Book Club – http://fourhourbook.club/ 

• Tim Ferriss’ Podcast – https://tim.blog/podcast/ 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com 

Timestamps 

• 00:00 Introduction to Early Episodes 

• 00:57 The Human Upgrade with Tim Ferriss 

• 01:58 Smart Drugs and Their Effects 

• 05:09 Experimenting with Health and Performance 

• 13:53 The Role of Creativity and Writing 

• 17:05 Exploring Nutrition and Insect Protein 

• 21:01 Handling Criticism and Audience Responsibility 

• 30:04 Sex, Performance, and Longevity 

• 33:21 Tim Ferriss’ Top Three Life Tips 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if everything you believe about happiness is wrong? 

In this episode, Harvard professor and world-renowned happiness expert Arthur Brooks joins Dave Asprey to unlock the secrets of real happiness, revealing the science behind joy, resilience, and lasting fulfillment. As a bestselling author and co-author with Oprah Winfrey of Build the Life You Want, Arthur has spent decades helping people rethink happiness through a blend of psychology, neuroscience, and ancient wisdom. 

Together, Dave and Arthur explore eye-opening topics like the “reverse bucket list,” why dopamine-driven goals often lead to disappointment, and how embracing discomfort can actually create deeper contentment. Arthur dives into why our common pursuits of fame, wealth, and success often fall short, and shares powerful strategies for mastering what’s within our control, building resilience, and finding meaning in life’s simplest moments. 

From managing dopamine to harnessing the power of small wins, this episode offers science-backed insights and practical tools to elevate your life with lasting joy and purpose. If you’re ready to transform your approach to happiness, tune in for strategies that truly work. 

Sponsors 

Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. 

ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:  

• Arthur Brooks’ Website – https://arthurbrooks.com  

• Arthur Brooks’ TED Talk: A New Way to Think About Happiness – https://www.ted.com/talks/arthur_brooks_the_art_and_science_of_happiness?subtitle=en&geo=es 

• Arthur Brooks’ Weekly Column: How to Build a Life in The Atlantic – https://www.theatlantic.com/author/arthur-c-brooks/  

• Dave Asprey’s Website – https://daveasprey.com  

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  

• Danger Coffee – https://dangercoffee.com  

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey  

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  

• Own an Upgrade Labs – https://ownanupgradelabs.com  

• Upgrade Labs – https://upgradelabs.com  

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com    

Timestamps 

• 00:00 – Introduction to Reverse Bucket List 

• 00:35 – The Science of Happiness 

• 00:58 – Personal Journey to Happiness 

• 01:44 – Meet Arthur Brooks 

• 04:26 – The Role of Music in Emotions 

• 07:43 – Understanding Emotions and the Brain 

• 09:50 – Parenting and Influence 

• 18:06 – Public Speaking and Performance 

• 34:10 – Striving for Success and Happiness 

• 39:40 – The Struggle with Body Image and Nutrition 

• 40:03 – Reverse Bucket List: Assessing Attachments 

• 40:57 – The Science of Dopamine and Motivation 

• 43:09 – The Dangers of Pornography and Dopamine 

• 44:03 – Biohacking and Pain Management 

• 47:03 – The Importance of Small Wins 

• 48:48 – Embracing Pain and Discomfort 

• 53:01 – The Role of Pain in Personal Growth 

• 56:12 – The Concept of Non-Resistance 

• 57:17 – The Happiness of Strivers 

• 01:01:13 – The Importance of Relationships and Spiritual Life 

• 01:03:22 – The Role of Fame and Legacy 

• 01:16:31 – The Value of Truthfulness and Compassion 

• 01:17:59 – Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Explore the science and potential of hypnosis as Dr. David Spiegel, Stanford’s leading expert in mind-body medicine, joins Dave Asprey to reveal how hypnosis can radically enhance cognition, mental clarity, and resilience. In this episode of The Human Upgrade, you’ll learn how hypnosis influences the brain’s most vital networks, including the default mode network and executive control, to break mental barriers and amplify focus, perception, and healing. 

Discover how hypnosis, unlike traditional meditation or neurofeedback, accelerates response times, manages pain, and even helps alleviate PTSD. Dr. Spiegel shares stories of patients overcoming chronic pain and trauma through self-hypnosis, and details the mechanisms that make hypnosis a powerful tool for emotional and physical transformation. 

Dive into the fascinating brain science behind the practice, from theta brainwave induction to deep sensory modulation, and learn simple self-hypnosis techniques that can elevate mental performance, improve sleep quality, and instill lasting calm. If you’re seeking a powerful, accessible way to biohack your brain and harness the potential of your mind, this episode delivers the insights and tools you need to make hypnosis your ultimate cognitive upgrade.   

Sponsors 

Quantum Upgrade | Go to Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

Resources: 

• Dr. David Spiegel’s Website – https://med.stanford.edu/profiles/david-spiegel 

• Reveri Hypnosis App – https://reveri.com (available on App Store and Google Play) 

• Dave Asprey’s Website – https://daveasprey.com 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement https://40yearsofzen.com 

Timestamps 

• 00:00 – Introduction to Hypnosis 

• 00:59 – Dave Asprey Introduces Dr. David Spiegel 

• 02:03 – Dr. Spiegel’s Journey into Hypnotherapy 

• 06:06 – The Power of Hypnosis in Medical Practice 

• 11:19 – Understanding Hypnosis and Brain Function 

• 16:14 – Hypnosis for PTSD and Trauma 

• 19:33 – Hypnosis vs. EMDR: Key Differences 

• 22:30 – Pain Management through Hypnosis 

• 31:06 – The Impact of Psychedelics on Cancer Patients 

• 33:04 – Exploring Psychedelic-Assisted Neurofeedback 

• 34:05 – Neuroimaging and Brain Activity in Hypnosis 

• 35:22 – Hypnosis and Cognitive Enhancement 

• 38:53 – Hypnosis for Sleep and Stress Management 

• 42:26 – Hypnosis and the “Manchurian Candidate” Concept 

• 48:21 – Hypnosis and the Immune System 

• 53:11 – Live Hypnosis Session with Dave Asprey 

• 58:46 – Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Unlock the mastermind secrets to cognitive enhancement as Dave Asprey shares his ultimate brain-boosting biohacks in this powerful episode of The Human Upgrade. Discover how Dave elevated his IQ, reversed Asperger’s, and overcame brain fog through advanced neurofeedback, BDNF-boosting supplements, mitochondrial enhancers, and the power of the groundbreaking 40 Years of Zen program. 

Explore revolutionary techniques, from ancient meditation practices to modern nootropics and smart drugs, all designed to amplify memory, focus, and resilience. Learn the science behind cognitive enhancement, from ketones like C8 MCT oil to essential supplements like Vitamins D, K, A, and magnesium that fuel optimal brain function. 

If you’re seeking proven methods to enhance neuroplasticity, boost mental endurance, or reduce brain fog, this episode is packed with actionable insights. Whether you’re aiming to maximize mental performance or unlock the latest in brain science, Dave’s mastermind approach offers a comprehensive guide to upgrading your mind and achieving peak potential. 

Prepare to boost cognitive abilities, harness your mind’s true power, and achieve new levels of clarity with Dave’s most effective brain and body biohacks—culminating in the transformative experience of 40 Years of Zen. 

Sponsors

40 Years of Zen | Neurofeedback training for advanced cognitive enhancement https://40yearsofzen.com/upgrade/

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula.

Resources: 

• Dave Asprey’s Website – https://daveasprey.com 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• Mendi Neurofeedback Device – Home neurofeedback device for attention and focus improvement https://www.mendi.io 

• Ketone IQ by HVMN – Go to https://ketone.com/dave for 30% off your first subscription of Ketone IQ.

• Qualia NAD – Support for mitochondrial function and cellular energy https://qualialife.com/dave (use code DAVE for discounts) 

• Vitamin DAKE – Fat-soluble vitamin complex designed by Dave Asprey https://vitamindake.com 

• Minerals 101 – Comprehensive mineral supplement for cognitive and metabolic support https://shopsuppgradelabs.com/products/minerals-101  

Timestamps: 

• 00:00 Intro 

• 00:32 Introduction to Cognitive Enhancement 

• 01:41 Dave’s Personal Journey and Struggles 

• 04:15 Discovering Cognitive Enhancement Tools 

• 11:36 Exploring Neurofeedback and Brain Training 

• 14:22 The Power of Mitochondria and Neuroplasticity 

• 23:45 Supplements for Cognitive Enhancement 

• 32:33 The Role of NAD+ in Brain Function 

• 34:41 Foundational Supplements for Brain Health 

• 36:17 Essential Supplements for Cognitive Function 

• 37:29 The Importance of Magnesium and Zinc 

• 39:14 Meditation and Breath Work for Brain Health 

• 40:07 Avoiding Toxins for Better Brain Function 

• 42:56 The Impact of EMFs on Brain Health 

• 46:25 Neurofeedback and Cognitive Enhancement 

• 01:05:01 The Power of Ketamine in Neurofeedback 

• 01:09:49 Final Thoughts and Recommendations 

• 01:09:49 Testimonials 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Unlock the secret to cellular detox and discover how to cleanse your body from the inside out with Dave Asprey and Jessica Berman in this episode of The Human Upgrade. Explore cutting-edge detox strategies using phosphatidylcholine, Tudca, and butyrate, three powerful molecules designed to remove toxins, microplastics, and endocrine disruptors from your system. 

Jessica, co-owner of BodyBio, reveals how these products support not just detoxification, but also optimize mitochondrial function, enhance brain performance, and improve overall cellular health. From phosphatidylcholine’s ability to restore cell membranes to Tudca’s role in liver health, you’ll learn how to protect yourself from the daily onslaught of environmental toxins that can harm your longevity and vitality. 

If you’ve been searching for how to reduce your toxic load, flush out microplastics, or boost cognitive function, this episode is packed with actionable insights. Whether you’re a biohacker looking to enhance your cellular resilience or someone curious about how these supplements can improve your overall health, this episode will take your detox game to the next level. 

Get ready to learn how to detox like a pro, rebuild your cell membranes, and optimize your brain and body with these game-changing biohacks! 

Resources:  

• BodyBio Phosphatidylcholine, Tudca, Butyrate & More – Get 25% off BodyBio products with code DAVEASPREY https://bodybio.com/collections/dave-asprey?affluencerId=Dave%20Asprey&linkId=Dave%20Asprey_Clear%20It%20All_Podcast

• Dave Asprey’s Website – https://daveasprey.com 

• The Human Upgrade Podcast – https://daveasprey.com/category/podcasts/ 

• Danger Coffee – https://dangercoffee.com 

• Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com

Timestamps: 

• 00:00 Intro 

• 00:30 Introduction and Importance of Grass-Fed Barbecue 

• 01:03 The Ubiquity of Environmental Toxins 

• 01:39 Minimizing Exposure and Detoxification 

• 02:47 Introducing Jessica Berman and BodyBio 

• 04:41 Understanding Cell Membranes 

• 08:55 Phosphatidylcholine and Its Benefits 

• 27:54 Clinical Observations and Future Research 

• 36:49 The Reality of Modern Toxins 

• 37:00 Understanding Lipophoric Toxins 

• 37:44 Detoxification Strategies 

• 38:30 The Role of Phospholipids 

• 39:16 Liver Health and Detox 

• 40:29 The Benefits of Tudca 

• 41:24 Choline and Fatty Liver 

• 42:20 Debunking TMAO Myths 

• 44:28 Soy Lecithin vs. Sunflower Lecithin 

• 47:21 Mitochondrial Health and Prenatal Care 

• 50:03 Biohacking for Healthy Aging 

• 55:35 The Importance of Phospholipids for Cognitive Health 

• 59:12 Mold Toxins and Health 

• 01:01:45 Building Resilient Humans 

• 01:05:02 Exclusive Offer for Listeners 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Step into the future of sports performance with The Human Upgrade as Dave Asprey and Aron D’Souza, founder of the Enhanced Games, uncover the controversial world of steroids, gene therapy, peptides, and human enhancement. In this groundbreaking episode, they explore how athletes can push the boundaries of physical and mental performance by embracing cutting-edge science once banned by traditional sports bodies like the Olympics. 

Discover why the Enhanced Games are redefining fairness in athletics, allowing competitors to use biohacking and performance-enhancing technologies to unlock new levels of strength, speed, and recovery. Aron breaks down the ethical dilemmas, the science behind enhancements, and why athletes should have full control over their bodies and biology. From synthetic growth hormones to the latest in gene therapy, this episode dives deep into the future of sports innovation. 

Whether you’re fascinated by the world of biohacking, curious about the next big revolution in sports, or want to understand how gene therapy and performance enhancers could impact human longevity, this episode delivers a thought-provoking look into the possibilities of superhuman performance. 

Could you be the world’s next super athlete? Age might soon be irrelevant! The future of athletic potential is wide open—are you ready to take the leap? 

Sponsors: 

• Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. 
• Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. 

Resources: 

• Enhanced Games – https://enhanced.org 

• Enhanced Games Instagram – https://www.instagram.com/enhanced_games/ 

• Dave Asprey’s Website – https://daveasprey.com