331 avsnitt • Längd: 65 min • Månadsvis
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows ’This Week in Virology’ (TWiV) and ’This Week in Parasitism’ (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
The podcast This Week in Microbiology is created by Vincent Racaniello. The podcast and the artwork on this page are embedded on this page using the public podcast feed (RSS).
TWiM explains how to recode E. coli so it uses only one stop codon, and an exploration of the mechanisms of bacterial adhesion within dental plaque.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains Pasteur’s relentless hunt for microbes in the air, and how bacteria hunt for prey by ixotrophy - using grappling hooks!
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email.
Become a patron of TWiM.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains the remarkable abilities of bacterial ice nucleating proteins to promote freezing of water, and cryoprotective proteins produced by worm microbiomes that prevent freezing.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explores the discovery of microbial enzymes, PETases, that can degrade ubiquitous plastics, and how exogenous peptidoglycan is a danger signal to trigger biofilm formation.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson.
Guest Mark O. Martin.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals that record high atmospheric methane growth has been driven by microbes, and the cecum as an adaptive niche for Salmonella typhi.
Hosts: Michael Schmidt, Petra Levin and Michele Swanson.
Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
From ASMCUE 2024, the conference on undergraduate education, TWiM speaks with Becky, Melanie, and Katriana about their careers and how they use TWiM in undergraduate microbiology education.
Hosts: Michael Schmidt and Mark O. Martin
Guests: Becky Seipel-Thiemann, Melanie Melendrez-Vallard, and Katriana Popichak
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM describes how to make concrete more ‘green’ by using microbes, and bacterial bioluminescence as an important regulator of multitrophic interactions in the soil.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and and Mark O. Martin.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains how ticagrelor alters the membrane of S. aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance, and the development of a novel continuous disinfectant technology that decreases healthcare-associated infections in ICUs by 70%.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM focuses on recent foodborne outbreaks of bacterial infections, and how nanopore sequencing technology can be used to identify pathogenic microbes and antimicrobial resistance genes in food products.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM travels to the U.S. Army Medical Research Institute of Infectious Diseases to learn how research conducted at USAMRIID leads to vaccines, drugs, diagnostics, and training programs that protect both warfighters and civilians.
Hosts: Michael Schmidt, Petra Levin and Michele Swanson. Guests: Norman Kreiselmeir, Christopher K Coat, Keersten Ricks, and Eric Nguyen Links for this episode:
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains a project to engineer the cow microbiome to reduce emissions of methane, and the finding of antibiotic resistance genes in the genomes of giant viruses.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains how bacterial community structure can be used to predict athletic performance in racehorses, and the idea that a tiny fraction of all species forms most of Nature.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Mark O. Martin.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains unique modifications in the energy conservation pathways linked to methanogenesis in an Archaeon, and mechanisms of white nose fungal invasion of cells from the Little Brown Bat.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM describes experiments to explore gut microbiota signatures of vulnerability to food addiction in mice and humans, and how a phage tail-like protein suppresses competitors in populations of bacteria of plants.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explores evolution and host adaptation of Pseudomonas infections of plants, and the impact of COVID-19 on ESBL-producing E. coli on urinary tract and blood infections.
Hosts: Vincent Racaniello and Michael Schmidt.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explores the deep-dwelling microbes that sculpt our planet, and the use of microbes in bioelectronics to manage inflammation.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
From ASM Microbe in Atlanta, Georgia, Arturo joins TWiM to reveal the threats that fungi pose to human health, including the notorious Candida auris and many more and how committed experts are researching ways to save us and our food supplies.
Hosts: Michael Schmidt, Mark O. Martin
Guest: Arturo Casadevall
Watch this episode: https://youtu.be/nKJe5xNUocU
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains a new mechanism for preventing lysogeny through temperate phage-antibiotic synergy, and Salmonella expansion in the murine gut dependency on aspartate derived from reactive oxygen species-mediated microbiota lysis.
Hosts: Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explores how climate change may be increasing our risks to infectious disease and then how the Odyssey literally comes alive in our microbial world but fear not, unlike the Trojans, the bacteria are fighting back and have developed resistance to this novel class of newly developed antimicrobials.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM explores the plasticity of the adult human small intestinal stoma microbiota, and survival and rapid resuscitation that permit limited productivity in desert microbial communities.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
Today on TWiM, a charcuterie invasion, and how that acid in your stomach may protect from the invading hordes of microbes.
Hosts: Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
Guest: Mark O. Martin
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM discusses the identification of natural products from reconstructed ancient bacterial genomes, and how plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection.
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reviews the ongoing cholera outbreak in Africa, and research showing that gut complement induced by the microbiota blocks pathogens and spares commensal bacteria.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals a new population in the blue cheese-making fungus Penicillium roqueforti and identification of a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.
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Links:
S. aureus drives itch and scratch behavior (Cell)
Staph scratches its itch (Cell)
A new class of antibiotics (Nature)
A new type of antibiotic (Nature)
Novel antibiotic targets LPS transporter (Nature)
New antibiotic traps LPS (Nature)
Macrocyclic peptide drugs (Science)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
A highly reduced TWiM team presents a study of the use of phage diversity in cell-free DNA to identify bacterial pathogens in human sepsis cases, and the evolution, persistence, and host adaptation of a gonococcal antimicrobial resistance plasmid that emerged in the pre-antibiotic era.
Hosts: Vincent Racaniello and Petra Levin
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Links for this episodeMusic used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to [email protected]
On the occasion of TWiM’s 300th episode, we discuss how two college students found a new antibiotic in soil, Barbara Iglewski’s passing, and Elio returns for an appearance.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Guest: Elio Schaechter
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
From ASM’s Conference for Undergraduate Educators 2023 in Phoenix, TWiM speaks with Amaya Garcia Costas and Gwendolyn Knapp about their approaches to undergraduate microbiology education, and how they use TWiM as part of their curricula.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Guest: Amaya Garcia Costas and Gwendolyn Knapp.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM provides thoughts on providing better training for a non-academic career, and help celebrate Black in Microbiology Week with a 2023 paper by Ari Kozik, a co-founder of Black Microbiologists Association and Assistant Professor at the University of Michigan
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reviews how a coating of lipoproteins provides a stabilizing environment on the inner membrane of Bacillus subtilis spores, and a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track mediators of inflammation in the gastrointestinal tract
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM discusses a dispute about whether the mycobiome plays a role in the development of cancer, and the structure and function of channels that are delivered to plant cells by pathogenic bacteria.
Hosts: Vincent Racaniello, and Michael Schmidt.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target.
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin,
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals that the ice cream manufacturing environment harbors psychrotrophic bacteria, and identification of a deadly bacterial strain causing widespread deaths of newborns in Uganda.
Hosts: Vincent Racaniello, Michael Schmidt, & Michele Swanson.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains personalized aerosilized phage therapy for a chronic lung infection, and using the combination of antibiotic and a DNA molecule that binds alpha-gal to reduce S. aureus infection in vivo.
Hosts: Vincent Racaniello and Michael Schmidt
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.
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Links for this episode:Music used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to [email protected]
TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeMusic used on TWiM is by Ronald Jenkees
Send your microbiology questions and comments (email or recorded audio) to [email protected]
From ASM Microbe 2023 in Houston, TWiM speaks with Mimi Goldschmidt about her remarkable career in microbiology which included training astronauts to safely bring moon rocks back to Earth.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin. Guest: Mimi Goldschmidt
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Links for this episodeMusic used on TWiM is by Ronald Jenkees
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM highlights viral defense and counter-defense: cGAS mediated ubiquitination to counter infection, and viral sponges that sequester nucleotide signals to inactivate immunity.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.
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Links for this episodeMusic used on TWiM is by Ronald Jenkees
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM describes a potential connection between a bacterial protein that damages DNA, and human cancers, and how to synthesize antimicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
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Links for this episodeMusic used on TWiM is by Ronald Jenkees
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat.
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeMusic used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to [email protected]
TWiM reveals environmental integrons, bacterial genetic elements notorious for their role in spreading antibiotic resistance, and how Salmonella invasion is controlled by competition among intestinal chemical signals.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episodeMusic used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to [email protected]
TWiM reveals a new type of satellite virus that requires only phage tails for producing infectious virus particles, and that highly virulent plague bacteria differs from its innocuous enteric predecessor by its resistance to lysis by human complement.
Hosts: Vincent Racaniello and Michael Schmidt. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeSend your microbiology questions and comments to [email protected]
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
TWiM reveals housefly dispersal of antimicrobial resistant bacteria, and a reproductive organ in squid linked to symbiotic bacteria.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM reveals quorum-sensing systems that regulate intestinal inflammation and permeability caused by P. aeruginosa, and how plasmids manipulate bacterial behavior through translational regulatory crosstalk.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
TWiM presents a protocol for evolving caffeine-tolerant yeast by high school students in the home, and how predator-prey dynamics change when multiple bacteria grow together in biofilms.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeSend your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains the synthesis in bacteria of new energy-dense biofuels that can replace rocket and jet fuels, and the use of nanopore sequencing to improve diagnosis and treatment of patients with serious infections.
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Links for this episode:
Biosynthesis of high energy biofuels (Joule)
Polyketide synthases in bacteria (PNAS)
Sequencing for diagnosis of serious infections (mBio)
Nanopore sequencing video (YouTube)
Emerging human pathogen Kodamaea ohmeri (Front. Micro)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase Effector.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.
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Links for this episode:•Magnesium modulates cell division frequency (J Bacteriol) •A. baumannii kills fungi (mBio)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses.
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Music used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to [email protected]
TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.
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Links for this episode:Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
On this episode of TWiM, we reveal widespread stop-codon recoding in bacteriophages that may regulate translation of lytic genes, and how Staphylococcus aureus inhibits Pseudomonas aeruginosa growth.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM presents evidence that over half of human pathogenic diseases are impacted by climate change, and considers how a novel prokaryote discovered next to an underground stream illuminates the pathway to multicellularity.
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Mark Martin.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals high rates of co-transformation of plasmids in E. coli overturns the clonality myth, and bacterial membrane vesicles as a novel strategy for extrusion of the antimicrobial bismuth in H. pylori.
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin
Links for this episodeBecome a patron of TWiM.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
Mark Martin returns to TWiM to join the discussion of how to design a complex gut microbiome, and protection of protists from virus infection by intracellular bacterial symbionts.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
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Links for this episodeMusic by Ronald Jenkees.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals how to inactivate norovirus on formica surfaces, and how to achieve antibiotic resistance by suppression of a frameshift mutation in an essential gene.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
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Links for this episodeMusic by Ronald Jenkees.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explores the activation of natural product synthesis using CRISPR interference in Streptomyces, and how light/dark and temperature cycling modulate Electron Flow in Pseudomonas aeruginosa biofilms.
Hosts: Vincent Racaniello, Michele Swanson, and Petra Levin
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM presents a novel mucosal COVID-19 vaccine based on a bacteriophage capsid, and potentiation of C. difficile infection severity by the gut bacterial community.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reviews discovery of a bacterium that is visible to the naked eye, and reversible resistance to bacteriophage by shedding of the bacterial cell wall.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM discusses citizen science surveillance of drug-resistant Aspergillus in garden soil, and the mechanism of action of a copper dependent antibiotic.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
From ASM Microbe 2022 in Washington, DC, Heran joins TWiM to discuss her career and her work on the agent of tuberculosis, Mycobacterium tuberculosis.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Guest: Heran Darwin
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM explains how spindle-shaped Archaeal viruses evolved from rod-shaped ancestors to package a larger genome, and transcriptional recording by CRISPR acquisition from RNA.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted by hydrophilins.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM reveals that the atypical antipsychotic quetiapine promotes multiple antibiotic resistance in E. coli, and treatment with Bifidobacterium lactis probiotic benefits patients with coronary artery disease.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
TWiM explains the use of lavender oil to disrupt Listeria biofilms, and how treatment of catheters with liquid silicone reduces associated urinary tract infections.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to [email protected]
TWiM welcomes new host Petra, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion system that is essential for virulence of a variety of bacterial pathogens.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.
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Links for this episode:Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
Mark returns to TWiM to join in a discussion of soil microbiota as game-changers in restoration of degraded lands, and discovery of a centimeter-long bacterium, the biggest yet discovered.
Guest: Mark O. Martin
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In this food-centric TWiM, we reveal the microbiomes of carnivorous vulture bees and of Gala apples from all over the world.
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Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis.
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TWiM explains how bacterial symbionts regulate tick blood feeding activity, and the reasons why antibiotics exist.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt
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On this episode of TWiM, how phages prevent other phages from invading their hosts without blocking their own reproduction, and plastic-degrading potential of microbes across the Earth.
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TWiM discusses antigenic variation within dengue virus serotypes, and an mRNA vaccine that induces antibodies against tick proteins and prevents transmission of the Lyme disease agent.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson
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TWiM reveals a study showing that positive interactions among bacteria are far more common than previously thought, and how acquisition of a single gene enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt
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Mark Martin returns to TWiM for a discussion of the observation that Gram’s stain does not cross the bacterial cytoplasmic membrane, and suppression of gingival inflammation and bone loss through host modulation caused by episymbiotic Saccharibacteria.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt
Guest: Mark O. Martin
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Petra Levin joins TWiM to tell three stories from her laboratory: how starvation induces shrinkage of the bacterial cytoplasm; plasticity of E. coli cell wall and how it influences antibiotic resistance across different environments; and induction of antibiotic resistance by Triclosan.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt Guest: Petra Levin
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On this episode of TWiM, using colicins to ferry DNA into cells through an iron transporter, and construction of highly efficient microbial fuel cells that produce more electrical current than previously observed.
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TWiM explores the role of biofilms in infection by coronaviruses, and development of a Shigella vaccine using outer membrane vesicles derived from Salmonella
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On this episode, an electrochemical scaffold that delivers safe doses of hypochlorous acid to treat wound infections in humans, and a method for sampling and monitoring bacteria and viruses on surfaces using plain paper stickers.
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt
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TWiM reveals how temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts, and the intracellular localization of toxin-antitoxin proteins in E. coli.
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Mark Martin returns to TWiM to discuss ways to increase diversity in our field, and the discovery of Borgs, giant extrachromosomal elements with the potential to augment methane oxidation. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt
Guest: Mark O. Martin
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TWiM explores whether ‘rewilding’ is a way to get back our missing gut microbes, and failure of bacteriophage therapy due to the production of neutralizing antibodies.
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The TWiM folk explore disruption of a Burkholderia intracellular niche by a cell death program, and an increase in Brucella infectiousness after intracellular passage.
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In this episode, how polysaccharides keep cyanobacteria afloat in the oceans so that they can carry out photosynthesis, and a symbiotic bacterium that protects honey bees from fungal infections.
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Foodie TWiM reveals that bacteria in human saliva are major components of Ecuadorian indigenous beers, and an unusual E. coli that produces atypical light cream-colored colonies in chromogenic agar.
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TWiM continues its food arc with an examination of the effect of peroxyacetic acid spray on the microbiome and sensory properties of beef, and explores asymmetry of the cell division machinery during sporulation.
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TWiM reveals the microbiome of sourdough starter cultures, and discovery of a novel family of prokaryotic nanocompartments involved in the metabolism of sulfur.
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TWiM explains how Vibrio biofilms are dispersed by polyamine signals, and the induction of inappetence by respiratory virus infection which causes alteration of the gut microbiome.
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TWiM reviews aspirin modulation of Fusobacterium nucleatum, a microbe that has been associated with colorectal cancer, and Elio tells us ‘What are vaccines’, a talk he recently gave to members of his community.
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The TWiM team reviews how variants of P. aeruginosa survive antimicrobial treatment, and a decrease in the antimicrobial resistance of the gut microbiome in the presence of the fungus C. albicans.
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Elio reveals his thoughts on the big themes of modern microbiology, followed by an analysis of the gut microbiome in patients with Parkinson’s disease.
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To celebrate ten years, TWiM asks former hosts and guests to provide their thoughts on how microbiology has contributed to our understanding of the microbial world.
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In this episode, hiring and training expectations for future biomedical life sciences faculty, and the roles of bacterial symbionts in deep-sea hydrothermal vent tubeworms.
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In this episode, how DNA of giant viruses has contributed extensively to the genome of green algae, and inhibition of E. coli virulence by a metabolic product of arachidonic acid in the intestinal epithelium.
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The TWiM team reviews Salmonella colonization of three-dimensional miniature intestinal organs, and identification of a circadian clock in a non-photosynthetic prokaryote.
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The TWiM team reviews the movie Jezebel, played against the background of the yellow fever epidemic of 1853 in New Orleans, and prokaryotic viperins, ancestors of the eukaryotic enzymes that synthesize antiviral molecules.
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TWiM explores the use of a bacterial protein to make highly conductive microbial nanowires, and how modulin proteins seed the formation of amyloid, a key component of S. aureus biofilms.
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Mark Martin returns to TWiM for a discussion of a predatory bacterium appropriately named Vampirococcus lugosii, and Elio reveals how bacteria can be used on the International Space Station to efficiently extract rare earth elements in microgravity.
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In this episode of TWiM, control of Campylobacter in raw chicken by zinc oxide nanoparticles in packaging material, and Salmonella enterica genomes from a16th century epidemic in Mexico.
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In this episode of TWiM, the hidden biochemical diversity in soil-dwelling Actinobacteria that could lead to a second Golden Era of antibiotic discovery, and structures of glideosome components reveals the mechanism of gliding in apicomplexan parasites.
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Ninecia and Chelsey, two of the founders of Black in Microbiology, join TWiM to discuss the goals of the organization, then we reveal survival of Deinococcus bacteria for 3 years in space, an experiment that addresses the panspermia hypothesis for interplanetary transfer of life.
Guests: Ninecia Scott and Chelsey Spriggs
You can watch this episode at https://youtu.be/1o1hh0I4rio
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TWiM presents an episode for mycophiles: how bacteria disarm mushroom pathogens, and the role of the CARD9 protein in protective immunity against pulmonary cryptococcosis.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson
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TWiM presents two unusual microorganisms, Erysipelothrix rhusiopathiae, heard by Elio in an episode of Doc Martin, and Roseomonas mucosa, which is being used to treat atopic dermatitis.
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The TWiM team explores how delivery of an enzyme into competitor cells leads to synthesis of (p)ppApp, depletion of ATP, deregulation of metabolic pathways, and cell death, and a refinement of our typical view of bacterial lag phase as a period of nonreplication.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt
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The TWiM team reveals the genetic mysteries of the Dead Sea Scrolls from sequencing of DNA, and 100 million year old living bacteria recovered from marine sediments.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt
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The TWiMmers explore detection of SARS-CoV-2 on surfaces in an ophthalmology examination room, the ability of stressed populations of Yersinia bacteria to survive antimicrobial treatment within host tissues, and how volatile organic chemicals produced by soil microbes attract arthropods which in turn disperse bacterial spores.
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Mark Martin joins TWiM to describe nano-sized parasitic bacteria that inhabit humans, and the construction of whole-cell biosensors for detecting arsenic in drinking water.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt
Guest: Mark O. Martin
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TWiM reveals a potential mucus-busting weapon for patients with cystic fibrosis, and bacteria in the intestinal tract that can oxidize cholesterol, leading to lower levels of the lipid in blood.
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TWiM reveals that methane-producing bacteria might survive beneath the surface of Mars, and identification of a cytopathogenic toxin in a bacterium associated with preterm birth.
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The TWiM discusses eradicating racism in academia and STEM, and a peptide from commensal bacteria that protects skin from damage caused by MRSA
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The TWiM team explains how breathing can transmit SARS-CoV-2, and how lack of breathing leads to loss of mitochondria in a multicellular parasitic animal.
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The TWiM team explains an experimental vaccine to prevent E. coli urinary tract infections, and the remarkable three-way symbiosis of narnaviruses, bacteria, and fungi.
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Links for this episodeThe TWiM team discuses saliva as more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swab and how Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough.
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A ferret model for infection by SARS-CoV-2, and how Neolithization lead to emergence of a human bacterial pathogen.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt
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Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response.
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Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect.
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The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease.
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The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples.
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The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt
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The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane.
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Hosts: Vincent Racaniello, Michele Swanson and Michael Schmidt
Guests: Deanna Beatty, Mark Hay, Gina Lewin, Frank Stewart, and Marvin Whiteley
At Georgia Tech, members and trainees of the Center for Microbial Dynamics and Infection discuss the identification of pathogen essential genes during coinfections, and how coral management can improve coral defenses against pathogens.
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From ASM Microbe 2019 in San Francisco, Vincent speaks with Victoria McGovern, Carl Nathan, and Dan Portnoy about advancing human health through innovative collaborations.
Host: Vincent Racaniello
Guests: Victoria McGovern, Carl Nathan, and Dan Portnoy
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The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts.
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The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell.
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Host: Vincent Racaniello
Guests: Nicholas Arpaia and Tal Danino
Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice.
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The TWiM team reveals thousands of small novel genes in the human microbiome, and a mutualistic symbiosis between marine protists covered with magnetosome-containing bacteria.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt
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Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt
Guest: Julie Wolf
Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic.
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Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students.
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Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms.
VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko
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From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review.
Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt
Guests: Susanna L. Harrisand Alex Politis
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The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance.
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The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components.
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The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.
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Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease.
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Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter
How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.
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The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.
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The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.
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The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
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The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome.
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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The TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.
Hosts: Vincent Racaniello and Michael Schmidt
Links for this episode
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.
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The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
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The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episode
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds.
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Episode Links:
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.
Host: Vincent Racaniello
Guest: Sam Sternberg
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake.
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows.
Host: Vincent Racaniello
Guest: John Warhol
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Links for this episode
State Microbe (Wikipedia)
Micro Minutes! (tumblr)
Warhol Science on Etsy
Periodic Table of Microbes (Amazon)
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Vincent speaks with Mark O. Martin about microbial centricity, teaching undergraduates microbiology, lux art, painting with glowing bacteria, tardigrades and much more at ASM Microbe 2018.
Host: Vincent Racaniello
Guest: Mark O. Martin
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Send your microbiology questions and comments (email or recorded audio) to [email protected]
The TwiModulators discuss aerosolization of bacteria and viruses in an ocean-atmosphere mesocosm, and how the common practice of decontaminating produce with chlorine produces viable but non-culturable pathogens.
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Multistate foodborne outbreak investigations (CDC)
The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson
Guest: Christina Kellogg
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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The TWiM team discuss bacteriophage evolution in a dairy plant, and killing of less fit cells among social microbes.
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Elio Schaechter.
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Links for this episode
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer.
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
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Links for this episode
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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The TWiM team notes the passing of Allan Campbell, and explains how aminoglycoside antibiotics like neomycin enhance host resistance to viral infection.
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Send your microbiology questions and comments (email or recorded audio) to [email protected]
The TWiMsters explain why untreatable typhoid fever might be on the way, and the evolution of fungal virulence in tropical frogs.
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
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Links for this episode
Extensively drug resistant Salmonella typhi (mBio)
A Gathering Storm (mBio)
Typhoid vaccine recommendations (CDC)
Changes in dynamics of frog fungal disease (Science)
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The Masters of the Microbiological Universe discuss the humongouest fungus, and a commensal bacterium that protects against skin neoplasia.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Fertile prototaxites (Proc Royal Soc B)
The humongousest fungus (STC)
Commensal Staphylococcus protects against skin cancer (Sci Adv)
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The TWiMmers discuss culture-independent discovery of malacidin antibiotics, and unfolding of relaxase during bacterial conjugation.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Malacidins from soils (Nat Micro)
Excellent antibiotic resistance threat report (CDC, pdf)
Jo Handelsman on Women’s History Month (CBS)
Unfolding relaxase during bacterial conjugation (J Bact)
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The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps.
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
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Links for this episode
Bee larvae require fungal steroid to pupate (Sci Rep)
Biofilm refuge for tumorigenic bacteria (Science)
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The TWiM team reveals that spread of plague was likely by human ectoparasites, not rats, and deconstruct a durable, broadly protective protein nanoparticle influenza virus vaccine.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Ectoparasites and plague (PNAS)
SIR model for spread of disease (MAA)
Protein nanoparticle flu vaccines (Nat Commun)
Food washing (USDA)
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The cast of TWiM reveals how uropathogenic E. coli use a copper-binding protein to treat copper as a nutrient or a toxin, and Antarctic soil bacteria that survive on trace atmospheric gases.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Copper import in E. coli (Nat Chem Biol)
Conversion of OD to cells/ml for E. coli
Nutritional immunity with Jennifer Bomberger (TWiM#141)
Microbes live on atmospheric trace gases in Antarctic soil (Nature)
Antarctic terrestrial ecosystem (SciHub)
Hypolith (Wikipedia)
Breatharians (Broadly)
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Dickson joins the TWiM team to discuss the nasal microbiota of dairy farmers, and attenuation of bacterial virulence by quorum sensing in the maize weevil.
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Guest: Dickson Despommier
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Links for this episode:
Nasal microbiota of dairy farmers (PLoS One)
Measuring species richness, diversity, similarity (pdf one, pdf two)
Quorum sensing attenuates virulence (Cell Host Micr)
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How pandemic influenza viruses suppress immunogenic cell death, and 3D printing of bacteria into functional materials.
Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater.
Hosts:
Vincent Racaniello and Elio Schaechter.
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Links for this episode
Glycosylation site on influenza H3N2 viruses (PNAS)
Biohydrogen production by Thermotoga (Waste Man)
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The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
Links for this episode:
From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria.
Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang
Watch the video version! https://www.youtube.com/watch?v=ifGCe-qfnA0
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Links for this episode:
This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation.
Links for this episode:
The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Fungus killing fire salamanders (Nature)
Chlamydia with flagella (ISME J)
Flagellar movement in rickettsia (PLoS One)
Letters read on TWiM 162
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This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Tainted Houston floodwaters (NYTimes)
Peter Hotez on TWiP 29
FAQ: Microbiology of Built Environments, American Academy of Microbiology
Microbiomes of the Built Environment: A Research Agenda for Indoor Microbiology, Human Health, and Buildings, The National Academies of Sciences
Eukaryotic mating induced by bacterial enzyme (Cell)
Image credit: Arielle Woznica
Nicole King on TWiEVO 11
Send your microbiology questions and comments (email or recorded audio) to [email protected]
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus.
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episode
Regional Zika update, Americas (PAHO, WHO)
FGCU, Zika (TWiV 454)
Archaeal plasmid travels cell to cell via vesicles (Nature Micro)
Send your microbiology questions and comments (email or recorded audio) to [email protected]
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.
The TWiM team considers a report on prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Prokaryotic viral sequence in the brain (PNAS)
Diarrhea clears enteric pathogens (Cell Host Microbe)
Tight junction biology (Turner Laboratory)
Send your microbiology questions and comments (email or recorded audio) to [email protected]
The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection.
Hosts:
Vincent Racaniello, Michele Swanson and Elio Schaechter.
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Links for this episode
Role of Streptomyces in moonmilk (bioRxiv)
Moonmilk (Wikipedia)
Ancient proteins for virus resistance (Cell Rep)
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The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Molecular beacons identify gifted microbes (J Antibiot)
Defensive symbiosis (PLoS Path)
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Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Legionella in Flint water (The Scientist)
Q fever with Robert Heinzen (TWiM Special)
Horizontally acquired genes boost C. burnetii (Front Cell Inf Micro)
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At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Watch the video version recorded live at ASM Microbe 2017!
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Links for this episode
Pathogenic potential of a microbe (mSphere)
Rigorous science (mBio)
Funding by lottery (mBio)
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The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from latent reservoirs.
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Landscape of type VI secretion (BioRxiv)
Type VI secretion structure (jpg)
Activation of dormant E. coli in urinary tract infection (PLoS Path)
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The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells.
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
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Links for this episode
Chemoautotrophic symbiosis in giant shipworm (PNAS)
There’s gold in them hills (TWiM 97)
Vertebrate-algal symbiosis (eLife)
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The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths.
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
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Links for this episode
Bat sources of novel antifungals (AEM)
White nose syndrome in US (jpg)
Symbiont-derived antimicrobials (Cell Chem Cell)
Bacteriocins (Wikipedia)
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In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that Ureaplasma species can cause a system metabolic disturbance, hyperammonemia.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
Guest: Robin Patel
Links for this episode:
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The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication.
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Special guest: Pat Schloss
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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
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Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
Send your microbiology questions and comments (email or recorded audio) to [email protected]
The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation.
Hosts:
Vincent Racaniello, Michele Swanson, Michael Schmidt, and Elio Schaechter.
Links for this episodePhosphate needed for Cryptococcus brain disease (mSphere)
Type VI killing drives phase separation (Nat Rep)
Type VI secretion review (Phil Trans Roy Soc)
Microbial cooperation and conflict (TedX)
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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twim
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Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny.
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guest: Robert Heinzen
At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, Coxiella burneti.
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Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower.
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The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria.
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episodeThis episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Right click to download TWiM#143 (32 MB .mp3, 66 minutes).
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Links for this episode
Electrochemical scaffold to eliminate persistent biofilms (npj Biofilms Microbiomes)
Experimental setup for electrochemical treatment of biofilm (pdf, from article)
Acquisition of phage sensitivity by transfer of cell receptors (Cell)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.
Hosts:
Vincent Racaniello, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodePhenylpyrroles: Nearly no resistance (Front Micro)
Membrane-thickness caliper (J Bact)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.
Hosts:
Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
Guest: Jennifer Bomberger
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeVirus dysregulation of nutritional immunity (PNAS)
Podcast article mentioned by Michael
Compromised defenses (PLoS Path)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Host: Vincent Racaniello
Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel
At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.
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Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth.
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Register today for the 2017 ASM Scientific Writing and Publishing Online Course at bit.ly/swpoc17
Send your microbiology questions and comments (email or mp3 file) to [email protected]
The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii.
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeImage in audio player: Molecular surface of a Human rhinovirus, showing protein spikes. By: Wiki user: Robin S
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires.
Hosts: Vincent Racaniello, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
Hosts: Vincent Racaniello and Michael Schmidt
Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.
Links for this episode
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to [email protected]
Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.
The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.
Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode.
Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your microbiology questions and comments (email or mp3 file) to [email protected]
The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.
Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Agar Art Contest and ASM Grant Writing Course
Send your microbiology questions and comments (email or mp3 file) to [email protected]
The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.
A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.
Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
Guest: Harris Wang
Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeIdentification of a novel Borrelia species causing Lyme disease (Lancet Inf Dis)
Parasite wonders with Bobbi Pritt (TWiP 75)
Reported cases of Lyme disease (CDC)
Signs and symptoms of Lyme disease (CDC)
American Academy of Microbiology FAQ Human microbiome
Host fecal microRNA shapes gut microbiota (Cell)
Live Tiny, Die Never - Tardigrade T-shirt
This episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Host: Vincent Racaniello
Special guests: Rebekah Kading and Wyndham Lathem
From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello and Elio Schaechter.
Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by Ali Zifan - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.
Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson
On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeThis episode is sponsored by ASM Microbe 2016 and ASM Biodefense
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
The TWiM team marvels over the finding of a completely nitrifying Nitrospira, and horizontal gene transfer from Wolbachia into an animal genome.
Links for this episode:
This episode is sponsored by ASM Microbe 2016 and ASM Biodefense
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson
The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans.
Links for this episodeThis episode is sponsored by ASM Biodefense and the 32nd Clinical Virology Symposium.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected].
Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells.
Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!
Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the laboratory has advanced the science and teaching of microbiology, and discuss faculty work on uropathogenic E. coli, induction of stress by bacterial infection, and the gut microbiome.
Visit microbeworld.org/twim for more including the special video version of this episode.
Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation sequencing and advanced molecular diagnostics.
Visit microbeworld.org/twim to watch the video version and for complete shownotes including links mentioned.
The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus.
Image: Lesion formation on banana surfaces infected with Aspergillus terreus. Source
Links mentioned:
Visit microbeworld.org/twim for more.
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeMusic used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeAkkermansia muciniphilia and obesity (Gut)
A. muciniphilia genome (Biol Direct)
Alterations of gut microbiota and C. difficile colonization (mBio)
Association for Women in Science
The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.
Links for this episode:
Antimicrobial peptides to modulate microbial ecology (PNAS)
Targeting specific bacteria in the oral microbiome (Trends Micro)
How Wolbachiakills male hosts (PLoS Biol)
Wolbachia phage on TWiV 332
Image: Transmission electron micrograph of Wolbachia within an insect cell.
By: Scott O'Neill - Genome Sequence of the Intracellular Bacterium Wolbachia. PLoS Biol 2/3/2004: e76.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
The professors of TWiM discuss a University of Wisconsin plan for rescuing biomedical research in the US, and results of a clinical trial in Bangladesh of an oral cholera vaccine.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeHosts: Vincent Racaniello and Michael Schmidt.
Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.
The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis.
Links for this episode:
Microbes in whole-leaf herbs (J Appl Micro)
Antimicrobial peptide blocks ribosome (Nat Struct Mol Biol)
Bacterial protein synthesis (Micro Mol Biol Rev)
Antimicrobial peptides (Nature)
The battle for tryptophan (Front Cell Infect Micro)
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeMeasles vaccination prevents all-cause infectious disease (Science)
Master of contagion (The Loom)
Video: Measles incidence to immunomodulation (Science)
Metabolism links biofilms and colon cancer (Cell Metab)
Scripps Center for Metabolomics
Scripps metabolite database
Sponsors for this episode: SciMedSolutions, ICAAC-ICC
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
The TWiM team is amazed by the ocelloid, and an evolutionary battle for iron between mammalian transferrin and bacterial transferrin-binding protein.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
The TWiM team discusses evidence that serotonin synthesis is regulated by spore-forming members of the gut microbiota.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Image: Serotonin temporary tattoo by flickr user: ChezShawna
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
The TWiMers discuss how aroma helps disperse yeast cells on insect vectors, and evidence that MRSA is transmitted within households.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Jo Handelsman.
The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Image: Yellow colonies of S. aureus on a blood agar plate, note regions of clearing around colonies caused by lysis of red cells in the agar By: HansN. on wikimedia. From the study (Nat Gen) "...only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits."
Hosts: Vincent Racaniello
Guests: Maria Julia Marinissen, Edward H. You, and David R. Howell
Vincent meets up with Maria, Edward, and David at the ASM Biodefense and Emerging Infections Research meeting to talk about alternative careers for scientists.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
A video version of this episode is available at microbeworld.org/twim Links for this episode:
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
The TWiM crew ponders the question of how a bacterium finds its middle when dividing, then divulge the transfer of interbacterial antagonism genes to eukaryotes, where they may function in innate defense.
Links for this episode:
Size independent symmetric division (Nat Commun)
How does a bacterium find its middle? (Nat Struct Biol)
Genes transferred from bacteria augment eukaryotic defenses (Cell)
Antibacterial gene transfer (eLife)
Visit microbeworld.org/twim for complete shownotes and more.
The TWiM team reveal how bacteria in a shipworm’s gills help digest wood in the gut, and an approach that identifies a new antibiotic from the soil.
Links for this episode:
Gill bacteria enable a novel digestive strategy (PNAS)
Killing bacteria without resistance (Nature)
An irresistable newcomer (Nature)
Peptidoglycan synthesis animation
10 x 20 initiative (IDSA)
Visit microbeworld.org/twim for more.
Hosts: Vincent Racaniello.
Special guest: Rob Knight
Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants.
Check out the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello.
Special guest: Stanley Maloy
Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app. Links for this episode:Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.
Links for this episode:
Unicellular cyanobacterium and alga symbiosis (Science)
Diversity of nitrogen-fixing cyanobacterium and its host (Environ Micro)
Coccolithophore (Wikipedia)
Visit microbeworld.org/twim to view the complete shownotes and entire back catalog.
Vincent, Elio, and Michael reveal that a soil-dwelling nematode can recognize and respond to a bacterial quorum sensing molecule through a sensory neuron.
Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.
Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City.
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Vincent meets up with Laurene and David at the Annual Meeting of the Southern California Branch of the American Society for Microbiology, where they discuss how the Los Angeles County Department of Health is preparing for an outbreak of Ebola virus infection, and Cepheid’s game-changing, modular PCR system for the diagnosis of infectious diseases.
Vincent, Michele, and Michael discuss how a gene from bacteria protects a tick from plant cyanide poisoning, and enhanced transmission of Streptococcus pneumoniae by influenza virus co-infection in mice.
Michele speaks with members of the Department of Bacteriology at the University of Wisconsin - Madison, on the occasion of its designation as a Milestones in Microbiology site, where they discuss how the department has advanced the science and teaching of microbiology.
Vincent, Elio, and Michael explore the fossilization of archaeal lipids, and highlight the recent ICAAC in Washington, D.C.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
Vincent, Elio, Michael, and Michele consider whether our eating behavior is manipulated by gastrointestinal microbiota, and an aphid gene of bacterial origin whose gene product encodes a protein that is transported to an obligate endosymbiont.
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Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent, Elio, Michael, and Michele discuss the diel transcriptional rythmns of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.
In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.
Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.
Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of neonates.
Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episodeSend your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling Salmonella by modulating host iron homeostasis.
Hosts: Vincent Racaniello, Elio Schaechter, and Michele Swanson.
Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas.
Links for this episode:Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.
Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn.
Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.
Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.
Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.
Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.
Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS.
Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.
Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.
Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological profiling to identify pathways targeted by antibiotics.
Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.
Hosts: Vincent Racaniello and Michelle Swanson.
Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice.
Links for this episode:Fighting obesity with bacteria (Science)
Send your microbiology questions and comments (email or mp3 file) to [email protected], or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent and Michael recorded this episode at the 53rd ICAAC in Denver, where they spoke with James Gern and James Johnson about rhinoviruses and extra-intestinal pathogenic E. coli.
Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid
Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.
Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.
Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.
Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.
Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates.
Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria.
This episode was filmed live at ASM GM 2013 in Denver, CO. Visit www.microbeworld.org/asmlive to watch the full video archive of this episode as well as all the videos recorded during GM.
Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.
Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.
Vincent, Michael, and Stanley review the scientific career of Carl Woese.
Vincent, Michael, and Elio discuss the HIV co-receptor CCR5 as a receptor for S. aureus leukotoxin ED, and the vineyard yeast microbiome.
Vincent, Michael, and Jo discuss how subtle gender bias of science faculty favors male students, and the relationship of invasive infection and antibody orientation at bacterial surfaces.
Horizontal transfer of antibiotic resistance genes on metal surfaces, and using bacteriophage to reverse antibiotic resistance.
Vincent, Michael, and Elio meet up with Jonathan Dworkin to discuss how bacteria form spores and how they return to vegetative growth.
Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.
Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.
**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!**
Vincent and Stanley meet with Waclaw Szybalski and John Kirby at Cold Spring Harbor Laboratory on the occasion of its designation as a Milestones in Microbiology site. They reminisce about how the well known laboratory has advanced the science and teaching of microbiology, and discuss John’s work on the soil dwelling, predatory myxobacteria.
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This video is also available for free at www.microbeworld.org in the TWiM section, epsiode #40.
Vincent, Michael, and Elio reviews chapters from Microbes and Evolution, a collection of short, personal essays by microbiologists.
Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.
Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.
Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.
Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter
Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas.
Right click to download TWiM #34 (50 MB .mp3, 69 minutes).
Links for this episode:Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut.
Links for this episode:Send your microbiology questions and comments (email or mp3 file) to [email protected] ,
Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus.
Hosts: Vincent Racaniello, Jo Handelsman, and Michael Schmidt
Vincent, Jo, and Michael discuss an archetypal protein transport system in bacterial outer membranes, and evidence that gut microbial enterotypes might not fall into defined groups.
Links for this episode:
On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.
On episode #29 of the podcast, Vincent and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.
Vincent, Michael, and Elio review how competition within a host drives virulence of Streptococcus pneumoniae, and the expanding universe of the bacterial cytoskeleton.
Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.
Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria.
Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.
Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.
Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.
Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.
Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.
Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.
Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.
On episode #14 of the podcast This Week in Microbiology, Stanley, Margaret, Michael and Elio review how the fungus Cryptococcus escapes from macrophages, and electrical conductivity in nanowires formed by the bacterium Geobacter.
On episode #13 of the podcast This Week in Microbiology, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a probiotic-derived soluble protein to the colon.
Vincent, Margaret, Michael and Elio review the use of photothermal nanoblades to dissect the Burkholderia intracellular life cycle, and manipulation of chromosomes in vivo for genome-wide codon replacement in E. coli.
Vincent, Margaret, Michael and Elio review the presence of extended spectrum beta-lactamase genes in chicken meat and in humans, and a beneficial effect of Helicobacter pylori colonization on the development of allergen-induced asthma.
On episode #10 of the podcast This Week in Microbiology, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri.
Vincent, Michael, and Cliff review the outbreak of bloody diarrhea and hemolytic uremic syndrome in Germany caused by Shiga toxin-producing Escherichia coli O104:H4.
Vincent, Michael, and Stanley recorded TWiM #8 live at the 2011 ASM General Meeting in New Orleans, with guests Andreas Baümler, Nicole Dubilier, and Paul Rainey. They spoke about how pathogens benefit from disease, symbioses between chemosynthetic bacteria and marine invertebrates, and repetitive sequences in bacteria.
Vincent, Cliff, Elio, Margaret, and Michael discuss programmed cell death in E. coli, and the daily synthesis and degradation of enzymes needed for photosynthesis and nitrogen fixation by cyanobacteria.
Vincent, Cliff, Michael and Elio review the use of bacteriophages to manage infections, and the presence of antibiotic resistance genes in the bacteriophage from urban sewage and river water.
Vincent, Ron, Cliff, and Michael discuss the genome sequence of a mercury-methylating bacterium and the antimicrobial effects of nanoparticles.
Vincent, Cliff, Margaret, and Michael review foodborne bacterial illness in the context of outbreaks associated with cantaloupes and Lebanon bologna.
Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.
On episode #1 of the podcast This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.
En liten tjänst av I'm With Friends. Finns även på engelska.
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