The Dr. Hyman Show

Good sleep does more than recharge you—it can improve your mental clarity, mood, and long-term health. In this episode of “The Doctor’s Farmacy,” Dr. Mark Hyman looks back on his conversations with experts Andrew Huberman, Bryan Johnson, and Dr. Cindy Geyer to explore how light, food, and stress affect your sleep quality. You’ll get actionable tips to fix your sleep routine and learn why a restorative night’s rest is critical for protecting against cognitive decline and chronic disease.

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Full-length episodes of these interviews can be found here:

How to Rewire Your Brain For Sleep

The Science of Living Longer: Diet, Supplements, & Sleep

What Is Driving Your Poor Sleep And How Can You Fix It?

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Forget counting sheep—let’s talk about the simple and scientifically-proven tweaks that’ll have you sleeping like a pro. In this episode, I’m revealing my personal routine that turned my restless nights into deep, uninterrupted sleep. Learn how to fix those sneaky issues like blood sugar dips, nighttime stress, and even mouth breathing. If you’re tired of being tired, this is the episode you don’t want to miss.

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This episode is brought to you by AG1, Big Bold Health, and Seed.

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Navigating menopause doesn’t have to be difficult, but too often, women are left without the proper tools to manage their symptoms. In this episode, Dr. Mary Claire Haver joins me to unpack the real reasons behind hormonal imbalances during perimenopause and menopause. We dive deep into bioidentical hormone therapy, lifestyle changes, and how environmental toxins might be affecting your hormones more than you realize.

In this episode, we discuss:

• The benefits of using bioidentical hormones to manage menopausal symptoms and improve quality of life.
• Addressing hormonal imbalances early, before full menopause, to prevent more severe symptoms like osteoporosis and cardiovascular issues.
• How progesterone, especially in oral or topical form, can be a "miracle" solution for sleep and mood regulation during menopause.
• Estrogen’s role in cardiovascular and sexual health
• The "menopause toolkit," which includes hormone therapy, nutrition, exercise, sleep optimization, and stress reduction
• The impact of environmental toxins, such as endocrine disruptors, on women’s hormonal health, particularly during menopause.

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This episode is brought to you by Rupa Health, Mitopure, LMNT, and Wonderfeel.

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Most of us take breathing for granted, but it holds the key to transforming your health. In this episode, I dive into powerful conversations with James Nestor and Wim Hof about how mastering your breath can boost your immune system, reduce stress, and even manage chronic inflammation. You’ll discover why nose breathing is essential for overall wellness, how cold exposure enhances cardiovascular health, and why The Wim Hof Method is changing lives. If you’ve been ignoring your breath, it’s time to wake up—this episode will show you how to harness the power of breath for better physical and mental health.

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Full-length episodes of these interviews can be found here:

The Power Of Breath As Medicine

Why Ice Water Immersion And Your Breath Is The Key To Health And Happiness

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Feeling tired, sick, or struggling with stubborn health issues? It might be time to check your vitamin D levels. In this episode, I explore why vitamin D is the secret to better health—covering everything from its role in preventing chronic diseases like heart disease and cancer to how it boosts your immune system. I’ll break down the symptoms of deficiency, why regular testing is a must, and how to get vitamin D safely through sun exposure and supplements.

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Is the thought of aging holding you back, or could it be your chance to thrive? On this episode of “The Doctor’s Farmacy,” I sit down with Chip Conley to challenge the outdated view of midlife as a time of decline. We explore how this stage can become a period of growth, from finding new passions to building deeper connections. Learn why happiness often increases after 50 and get actionable tips for staying active, curious, and engaged.

In this episode, we discuss:

• Research on the U-curve of happiness, showing that life satisfaction typically dips around ages 45-50 but improves steadily with each decade after.
• The importance of social wellness and relationships as a key factor for longevity and well-being
• The Modern Elder Academy
• Overcoming the fear of aging
• The importance of maintaining curiosity and openness to new experiences, which are strongly correlated with living a longer, happier life.

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This episode is brought to you by Rupa University, BIOptimizers, Armra, and Qualia.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

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80% of us aren’t getting enough magnesium—and this impacts everything from migraines to muscle cramps, blood pressure, and even stress levels. On this episode of “The Doctor’s Farmacy,” I share insights from top experts like Dr. Todd LePine, Dr. George Papanicolaou, and Dr. Elizabeth Boham on how magnesium impacts your overall well-being. Learn why standard tests often miss a magnesium deficiency, how to get tested properly, and which foods and supplements can help you restore your levels. Don’t ignore this crucial mineral—your health depends on it.

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Full-length episodes of these interviews can be found here:

How Magnesium Deficiency Impacts Your Health | Know Your Numbers

The Functional Medicine Approach To Ending Migraines

Treating The Underlying Causes Of High Blood Pressure with Dr. George Papanicolaou

Supplements: Useful Or Useless? with Dr. Elizabeth Boham

This episode is brought to you by Rupa Health and Big Bold Health.

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We’ve all been there: one too many drinks and the next morning feels like a nightmare. But why does alcohol make us feel so terrible? In this episode of “The Doctor’s Farmacy,” I’m uncovering the surprising reasons behind hangovers and how you can avoid them. Get ready for expert tips on hydration, supplements, and the real truth about that ‘hair of the dog’ myth.

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This episode is brought to you by Mitopure, AG1, and Big Bold Health.

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Stress isn’t just in your head—it’s rewiring your brain. In this episode, I sit down with Dr. Robert Sapolsky to dive into the science of stress and its profound impact on mental and physical health. We explore how chronic stress damages the brain, particularly the hippocampus, leading to cognitive decline and mood disorders. Tune in to learn powerful strategies for managing stress, from mindfulness to exercise, and discover what it means for your health and society at large.

In this episode, we discuss:

• The difference between short-term (acute) stress, which can be beneficial in small doses, and long-term (chronic) stress
• The impact of stress on brain health
• The argument that free will is an illusion, as our decisions and behaviors are largely driven by complex biological processes and environmental factors
• How stress interacts with genes and the environment, influencing behavior, health outcomes, and the body's ability to cope with stress
• How chronic stress triggers inflammation throughout the body, contributing to various health problems
• Effective ways to manage stress, including mindfulness, physical exercise, and proper nutrition

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This episode is brought to you by Rupa Health, Pendulum, Thrive Market, and Our Place.

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Head over to ThriveMarket.com/Hyman today to received 30% off your first order and a free gift up to $60.

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What if you could train your brain to handle stress better—just by meditating for a few minutes each day? In this episode of “The Doctor’s Farmacy,” I revisit conversations with Emily Fletcher, Dan Harris, and Daniel Goleman to explore how meditation rewires the brain, reduces anxiety, and enhances mental clarity. You’ll learn the science behind mindfulness, loving-kindness meditation, and other techniques that not only improve stress management but also promote overall mental health and wellness.

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Full-length episodes of these interviews can be found here:

Why Meditation is the New Medicine

Is one minute of meditation enough?

Meditation, Kindness, and Compassion: The Secret to Your Life and Financial Abundance

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Are you up to date on the doctor appointments that could save your life? In this episode, I dive into the essential screenings you can’t afford to skip, from mammograms and colonoscopies to functional lab tests that reveal much more than standard checkups. We’ll break down how conventional medicine is great for emergency care and early detection, but it often misses the root causes of illness.

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Every tap, like, and scroll on social media is feeding a mental health epidemic—and it’s targeting our youth. In honor of World Mental Health Day, a day dedicated to raising awareness and mobilizing efforts to support mental health worldwide, I'm sitting down with renowned social psychologist and author Jonathan Haidt, PhD to explore the dramatic rise in anxiety and depression among today’s youth. We’ll dive into the evolution of internet culture, the role of food systems in social disruption, and how we can turn the tide on these trends. If you’re concerned about the mental well-being of the next generation, tune in for actionable solutions.

In this episode, we discuss:

• The Rise of Depression and Anxiety in Gen Z
• The Link Between Social Media and Mental Health
• The Addictive Nature of Social Media Algorithms
• The Evolution of the Internet and Its Role in Childhood
• The Phone-Free Schools Movement
• The Influence of Ultra-Processed Foods on Mental Health

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This episode is brought to you by Rupa University, ButcherBox, Sunlighten, and Fatty15.

Practitioners: Dr. Casey Means is hosting a free class on metabolic dysfunction. To sign up, go to rupahealth.com/casey.

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Did you know changing your diet can dramatically reduce ADD/ADHD symptoms? In this episode, I look back on my conversations with Dr. George Papanicolaou, Dr. Jaquel Patterson, and Dr. Uma Naidoo on how sugar, gluten, and toxins like heavy metals are disrupting brain function and fueling these chronic disorders. You’ll discover the power of nutrient-dense foods, gut health, and functional medicine in managing ADD and ADHD naturally. If you're looking for solutions beyond medication, this episode gives you the tools to start healing from the inside out.

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Full-length episodes of these interviews can be found here:

Why ADHD Is Not A Psychiatric Disorder Or Brain Disease with Dr. George Papaicolaou

What’s Fueling Our Mental Health Crisis and How Can We Fix it? With Dr. Jaquel Patterson

Is Food to Blame for Your Anxiety and Depression?

This episode is brought to you by AX3, Mitopure, Seed, and OneSkin.

Get 20% off your first order of AX3's astaxanthin at ax3.life/hyman with code HYMAN at checkout.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

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Cancer rates are on the rise, but what you eat can make all the difference. In this episode, I explore the powerful relationship between food and cancer risk. From cutting down on sugar and processed foods to boosting your intake of anti-cancer superfoods like cruciferous vegetables and mushrooms, I’ll walk you through why a whole-food, nutrient-dense diet is your best defense against this disease.

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This episode is brought to you by Rupa Health, Manukora Honey, and Eudemonia.

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What if we could predict disease before it even starts? In this episode, I’m joined by Dr. Jeremy Nicholson to explore the cutting-edge science of precision medicine and how understanding your unique biology could hold the key to preventing illness. We dive into the future of diagnostics, the power of the exposome in shaping your health, and how advancements like gene editing could revolutionize treatment. 

In this episode, we discuss:

• The emerging field of phenomic medicine
• Moving away from one-size-fits-all treatments toward more personalized medical approaches based on individual biology
• Long COVID and its impact
• The critical role of the microbiome in overall health, immune system function, and its direct influence on diseases
• How the exposome, or all of the environmental exposures a person experiences, plays a crucial role in shaping health outcomes
• Advanced technologies like metabolic profiling, which can reveal subtle biochemical signals and identify disease risks long before symptoms appear.
• How gene-environment interactions drive the development of complex diseases, making personalized medical approaches crucial for effective treatment

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This episode is brought to you by Rupa Health, Cozy Earth, BIOptimizers, and Neurohacker.

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Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit Bioptimizers.com/hyman and use code HYMAN10 to save 10%.

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Have you ever wondered why it’s so hard to put down that bag of chips? In this episode, my guests Dr. Shebani Sethi and Calley Means and I break down how ultra-processed foods are contributing to the obesity epidemic, diabetes, heart disease, and even mental health issues. From understanding the science of addiction to decoding food labels, we’ll explore how big food companies are manipulating us—and what we can do to fight back.

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Full-length episodes of these interviews can be found here:

Why the Last Thing that Should Ever Eat is Ultra Processed Foods: It Kills 11 Million People a Year

How Does Ultra-Processed Food Affect Our Mental Health?

Calley Means: The Obesity Crisis, Ozempic, ADHD and Food Industry Lies

This episode is brought to you by Rupa Health, FOND, Ketone-IQ, and Happy Egg.

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Most people have no idea they’re missing out on essential nutrients—until it’s too late. In this episode, I expose the hidden truth behind nutrient deficiencies and why supplements are no longer optional when it comes to your health. Learn which supplements are vital to keep you feeling your best and how to navigate the confusing supplement market with confidence.

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This episode is brought to you by AG1, Seed, and Essentia.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get a year's worth of D3 and five Travel Packs for FREE with your first order.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

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Fatty liver disease is on the rise, but the good news is, it’s preventable and reversible. In this episode, I sit down with Dr. Yousef Elyaman to explore the silent epidemic and how early detection could be the key to saving your liver—and your health. We break down the latest in diagnostic tools and dive into powerful lifestyle interventions. Whether you’ve been diagnosed or want to stay ahead of the game, this episode is packed with practical advice to protect your liver and your health.

In this episode, we discuss:

• The importance of diagnosing fatty liver disease early through blood tests
• How dietary interventions, particularly the Mediterranean diet, can significantly improve or even reverse fatty liver disease
• Supplements that support liver function and reverse fatty liver disease
• How insulin resistance is a major contributor to fatty liver disease and why managing blood sugar levels is critical for liver health
• The connection between chronic inflammation and fatty liver disease
• How exposure to toxins and chemicals, including processed foods and environmental pollutants, contribute to liver damage and fatty liver disease

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This episode is brought to you by Rupa Health, BIOptimizers, LMNT, and Manukora Honey.

Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit Bioptimizers.com/Hyman and use code HYMAN10 to save 10%.

LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today.

Get your Manukora Honey Starter Kit today! Just head to Manukora.com/Hyman, to get $25 off.

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Struggling with skin issues like acne or rosacea? In this episode, I team up with Dr. Todd LePine and Dr. Elizabeth Boham to dive deep into the root causes behind chronic skin conditions. We break down how gut health, food sensitivities, and systemic inflammation are often at the heart of these issues. Learn how eliminating processed foods, gluten, and dairy can transform your skin, and why treating from the inside out is the key to lasting skin health.

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Full-length episodes of these interviews can be found here:

Treating Adult Acne & Rosacea From The Inside Out

How To Heal Skin Issues By Optimizing Your Nutrient Status And Fixing Your Gut

Treating Acne From The Inside Out with Dr. Elizabeth Boham

This episode is brought to you by Eudemonia, ButcherBox, and Cozy Earth.

For the full lineup and to purchase a ticket, visit Eudemonia.net.

ButcherBox is giving new members two pounds of wild-caught salmon for FREE plus $30 off. Visit ButcherBox.com/Farmacy and use code FARMACY30.

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Think weight training is just for bodybuilders? In this episode, I break down why building muscle is one of the most important things you can do for your long-term health. From improving insulin resistance and boosting your metabolism to enhancing mental clarity and protecting against chronic diseases like diabetes, heart disease, and Alzheimer's—muscle is the secret weapon you didn’t know you needed. I’ll also share practical tips for incorporating strength training into your routine, no matter your age or fitness level.

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This episode is brought to you by Mitopure, OneSkin, Seed, and AX3.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10.

Unlock your healthiest skin yet. Try OneSkin with 15% off your first purchase using code HYMAN15 at OneSkin.co today.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

Get 20% off your first order of AX3's astaxanthin at Ax3.Life/Hyman with code HYMAN at checkout.

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Have you ever experienced unexplained allergy-like symptoms, digestive issues, or persistent fatigue? It could be histamine intolerance, a condition that’s more common than you think. In this episode, Dr. Elizabeth Boham joins me to examine real patient stories, dive deep into the gut-brain connection, and share how you can manage histamine intolerance through personalized treatments, stress management, and gut health optimization. Whether it's genetic or lifestyle-related, histamine intolerance doesn't have to be a lifelong battle. 

In this episode, we discuss:

• The common symptoms of histamine intolerance
• The importance of the DAO enzyme
• Why low-histamine diets may not be a long-term solution
• Why stress and gut health are key triggers
• The difference between histamine intolerance and and mast cell activation syndrome (MCAS)

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This episode is brought to you by Rupa Health, Pendulum, ARMRA, and Our Place.

Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Pendulum is offering listeners 20% off their first membership order at PendulumLife.com/Farmacy. Discount applied at checkout.

Save 15% on your first order of ARMRA Colostrum and unlock the power of 400+ functional nutrients. Just visit TryARMRA.com/Mark or use code MARK.

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Is going gluten-free just a trend, or is it a legitimate step toward better health? In this episode, I’m joined by Dr. Alessio Fasano and Maggie Ward to explore the science behind gluten sensitivity and why modern bread could be at the root of many gut issues. We dive into the debate over gluten-free diets, discussing whether they’re necessary for everyone or only for those with celiac disease. We also examine how environmental factors like pesticides and hybridized wheat are disrupting the gut microbiome, leading to issues like leaky gut syndrome.

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Is Gluten-Free A Fad Or Is Gluten A Real Threat To Our Health?

Should We All Avoid Gluten?

What Would Happen If You Stopped Eating Bread For 30 Days?

This episode is brought to you by Momentous, AG1, and Happy Egg.

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Tired of dealing with constant bloating and discomfort? In this episode, I break down the root causes of IBS and other common gut problems, from food sensitivities and SIBO to the gut-brain connection and stress. We’ll explore why ultra-processed foods are wreaking havoc on your gut, and I’ll walk you through the 5 R program and strategies like the low FODMAP diet to heal your gut for good. If you're suffering from bloating, constipation, or gas, this episode is your guide to real relief.

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Muscle isn’t just about strength—it’s about longevity, metabolic health, and even immune function. In this episode, I sit down with Dr. Gabrielle Lyon to uncover the critical role that skeletal muscle plays in our overall health. We dive deep into muscle as an endocrine organ, its role in fighting insulin resistance, and why sedentary lifestyles are wreaking havoc on our bodies. From understanding how to build muscle effectively at any age to learning why muscle mass is the key to metabolic health, this conversation will change the way you think about strength training.

In this episode, we discuss:

• Exactly how much protein we need to eat every day
• The differences between plant and animal proteins
• The impact of resistance training
• The metabolic benefits of muscle
• Why you should spread your protein intake evenly throughout the day
• How sedentary behavior and insufficient protein intake can lead to muscle loss, insulin resistance, and metabolic disorders

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Are you getting enough vitamin D? This powerful nutrient does so much more than just support bone health—it’s essential for mood, energy, immunity, and even protection against serious diseases like cancer and COVID. Yet, approximately 80% of Americans are deficient due to limited sun exposure and the depletion of nutrients in our modern food supply. In this episode, I break down why vitamin D is critical for your health, the optimal levels you should aim for, and how to get your daily dose safely—whether through the sun, diet, or supplements.

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Full-length episodes of these interviews can be found here:

Do You Need To Take Vitamin D?

Supplements: Useful Or Useless? with Dr. Elizabeth Boham

The Science Behind Vitamin D, Our Rampant Deficiency, And Its Harmful Impact On Our Health

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We often think of trauma as those big, life-shattering events, but did you know that everyday stress can have the same lasting impact on your health? In this episode, I break down how both major and minor traumas affect your body at the deepest level—from your gut to your brain—and what you can do to heal. We’ll dive into the science of how trauma shapes your biology and explore the functional medicine strategies that go beyond traditional talk therapy. Whether you’ve been through a major event or are feeling the weight of everyday stress, this episode offers powerful tools to help you not just survive, but thrive.

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What if the key to fixing our broken healthcare system lies within Congress? On this episode of “The Doctor’s Farmacy,” I sit down with U.S. Representative Vern Buchanan to tackle one of the biggest crises facing our country: the rise of chronic disease and its staggering economic impact. We dive deep into why prevention, not just treatment, needs to be at the forefront of healthcare, and discuss the groundbreaking work being done in Congress to shift our focus toward nutrition, lifestyle changes, and medically tailored meals. 

In this episode, we discuss:

• The staggering economic burden of chronic diseases on the U.S. economy
• The importance of nutrition education for doctors and healthcare providers as a key factor in preventing chronic diseases
• Congressman Vern Buchanan’s bipartisan efforts to address the chronic disease epidemic through policy changes and initiatives like the Congressional Preventive Health and Wellness Caucus
• The impact of chronic disease on military readiness and national security
• The critical need for a shift in healthcare focus from treatment to prevention, emphasizing lifestyle changes and nutrition

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Did you know chronic stress can age your immune system faster than almost anything else? In this episode, I dive into the fascinating world of immune and lymph health with some of the leading experts in the field, including Dr. Mehmet Oz, Dr. Gerald Lemole, and Dr. Leonard Calabrese. We explore how stress, diet, and lifestyle can either rejuvenate or break down your immune defenses, leading to a host of chronic conditions. Learn practical, science-backed strategies to boost your immune resilience, reduce inflammation, and keep your body’s defenses in top shape.

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Full-length episodes of these interviews can be found here:

How To Reset Your Immune System At A Cellular Level

Why Our Neglected Lymph System Is A Key To Optimal Health

The Secrets to Creating a Healthy Immune System

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Could your persistent acne, eczema, or psoriasis be a sign of something more serious? Join me on "The Doctor’s Farmacy" as I reveal how chronic skin conditions are often linked to gut health and nutrient deficiencies. I’ll share practical tips on how to support your skin by healing your gut, optimizing your diet, and identifying the root causes of inflammation. It’s time to understand what your skin is really telling you and how to fix it.

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Do you ever feel like the more meds you take, the worse you feel? The problem might lie in how our healthcare system operates. In this episode, I sit down with Dr. Marty Makary to tackle the alarming rise of colon cancer among young people, explore how our microbiome plays a crucial role in preventing chronic diseases, and discuss the unsettling influence of the pharmaceutical industry on medical practices. From the impact of antibiotics on children to the hidden dangers of over-medication, we unpack the urgent need for more transparency and a shift towards addressing the root causes of illness.

In this episode, we discuss:

• The alarming increase in colon cancer among young people
• The microbiome's impact on overall health, from regulating the immune system to influencing mood and metabolism
• The deep influence of pharmaceutical companies on medical research, education, and policy, often at the expense of patient care
• The long-term health consequences of early antibiotic use in children
• The overmedication of Americans, particularly children, and the need for a shift towards addressing root causes of diseases

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Did you know that sugar is lurking in more places than you might think, and it could be sabotaging your health in ways you never imagined? In this episode, I look back on my conversations with Dr. Richard Johnson and Dr. Robert Lustig. We examine how certain foods, especially those loaded with sugar, can trigger overeating, disrupt your metabolism, and lead to a cascade of health issues. Plus, I'll share practical strategies for detoxing from sugar, managing blood sugar levels, and reclaiming your health.

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Full-length episodes of these interviews can be found here:

Why Sugar And Fructose Are So Deadly with Dr. Richard Johnson

Depressed or Anxious? You May Never Eat Sugar Again After Watching This

The True Dangers Of Sugar with Dr. Robert Lustig

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Are you tired of feeling tired all the time? You're not alone—burnout is one of the most common complaints I hear from patients. In this episode, I dive into the root causes of chronic fatigue, including how mitochondrial dysfunction could be sabotaging your energy levels. I’ll share my personal journey with chronic fatigue and explain how functional medicine can help you boost your energy and finally feel like yourself again.

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In a world where chronic illness and unexplained health issues are on the rise, understanding the root causes behind immune dysfunction is more important than ever. In this episode of "The Doctor's Farmacy," I'm joined by Dr. Elroy Vojdani to explore the critical issue of immune resilience and its connection to chronic illness. Dr. Vojdani shares groundbreaking insights from his father’s work on immune health, along with practical strategies to boost your immune system, tackle long COVID, and reverse chronic conditions through personalized, functional medicine approaches.

In this episode, we discuss:

• The Decline of Immune Resilience
• The Role of the Gut in Immune Health
• The Impact of Long COVID on the Immune System
• Molecular Mimicry and Autoimmunity
• The Connection Between Mitochondrial Dysfunction and Chronic Illness

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Ever wondered why you’re always tired, achy, or just not feeling your best? It could be chronic inflammation silently wreaking havoc on your health—but the good news is, there’s a way to stop it. Joined by experts Dr. Shilpa Ravella and Dr. David Furman, we explore the surprising ways your diet, environment, and even your daily habits might be fueling this silent killer. We break down the science behind inflammation, how it’s linked to almost every chronic disease, and what you can do to stop it in its tracks.

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What Causes Inflammation And How Can You Treat It?

The Silent Killer: Inflammation And Chronic Disease

How Silent Inflammation Accelerates Aging

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What if I told you that your breakfast habits might be sabotaging your entire day? In this episode of “The Doctor’s Farmacy,” I’m diving into the science behind starting your day right. Discover why a high-protein, nutrient-dense breakfast can set the tone for balanced blood sugar, reduced cravings, and improved cognitive performance. Plus, I’ll offer up some practical tips for making breakfast a powerful tool for maintaining a healthy weight and preventing chronic diseases.

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Did you know that inflammation could be the hidden culprit behind the skyrocketing rates of mental illness? In this episode, I sit down with Dr. Jaquel Patterson to discuss one of today's most pressing issues: the alarming rise in mental health disorders like depression, anxiety, ADHD, and bipolar disorder. We explore the connection between mental health, inflammation, and immune function, shedding light on post-COVID mental health challenges, brain inflammation, and the impact of environmental factors.

In this episode, we discuss:

• The mental health impacts observed post-COVID, highlighting the exacerbation of pre-existing conditions and new onset issues.
• The connection between brain inflammation and mental health disorders, emphasizing the role of chronic inflammation in conditions like depression and schizophrenia.
• The impact of environmental toxins on mental health.
• The potential benefits of sauna therapy for reducing inflammation and improving mental health.
• Functional medicine strategies for treating mental health disorders, including dietary changes, nutrient supplementation, and lifestyle modifications.

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So many people suffer from chronic Lyme disease without even knowing they have it. Why? Because it can mimic over 300 different medical conditions. On this episode of “The Doctor’s Farmacy,” I revisit my conversations with Dr. Steven Phillips, Dana Parish, and Dr. Todd LePine to unravel the complexities of Lyme disease and other tick-borne illnesses. We dive into the diagnostic and treatment challenges, and explore how functional medicine can offer solutions to your suffering. 

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Full-length episodes of these interviews can be found here:

Answering Your Questions About Lyme Disease, Detoxing, And More

The Link Between Autoimmune Disease, Chronic Fatigue, And Hidden Infections

How To Recover From Chronic Lyme And Tick Diseases with Dr. Todd LePine

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Have you noticed the scale inching up despite believing you're following a healthy diet? In this episode, I dive into why maintaining a healthy weight can be so challenging. We'll explore how diet, hormones, and environmental factors influence weight, and why understanding body composition is crucial. Plus, I'll provide actionable strategies, from balancing blood sugar to optimizing gut health, to help you achieve and sustain a healthy weight.

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What if the key to overcoming your autoimmune disease lies in your lifestyle? In this episode of "The Doctor's Farmacy," I’m joined by Dr. Robert Rountree to examine the alarming rise of these chronic conditions. We’ll dissect the root causes and holistic solutions to stop your suffering now. Tune in to discover how personalized lifestyle changes and functional medicine can offer hope and healing.

In this episode, we discuss:

• How toxins like heavy metals can trigger autoimmune responses and affect overall health
• The role of dietary triggers and food sensitivities in the development and management of autoimmune diseases
• The importance of gut health in autoimmune conditions, including the impact of microbial imbalances and the gut microbiome
• The significant role of stress and sleep in modulating immune responses and managing autoimmune conditions
• The importance of individualized lifestyle changes, including diet, stress management, and exercise, in managing and potentially reversing autoimmune conditions

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We all know mitochondria is “the powerhouse of the cell” thanks to middle school science class, but when does that mean when we’re talking about our overall health and longevity? In this episode, I dive into the fascinating world of mitochondrial health with Dr. Steven Gundry and Dr. Andrew Salzman. We discuss how optimizing mitochondrial function through diet, exercise, and light exposure can dramatically improve your health and energy levels. Plus, we explore the impacts of chronic inflammation, leaky gut, and environmental toxins on our mitochondria and overall well-being.

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Full-length episodes of these interviews can be found here:

4 Non-Negotiables To Boost Energy And Optimize Your Mitochondria

Sick And Tired Of Being Sick And Tired? How To Reclaim Your Energy

How Supplementing With NMN Can Increase NAD levels, Energy, Reduce Inflammation, And Improve Insulin Resistance

After a distinguished surgical career as a professor and chairman of cardiothoracic surgery at Loma Linda University, Dr. Gundry changed his focus to curing modern diseases via dietary changes. He is the author of New York Times bestseller The Plant Paradox, The Plant Paradox Cookbook, The Plant Paradox Quick & Easy,andThe Longevity Paradox,along with national bestsellersThe Plant Paradox Family Cookbook, The Energy Paradox,Dr. Gundry’s DietEvolution,andUnlocking the Keto Code, and has had more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He just released his latest book,Gut Check: Unleash the Power of Your Microbiome to Reverse Disease and Transform Your Mental, Physical, and Emotional Health.

Dr. Andrew Salzman is a physician, inventor, professor, and biomedical entrepreneur. Dr. Salzman received his medical degree from Harvard University and has spent decades in drug discovery and development, raising over $165M in NIH grants for research. In addition to 50 patents, Dr. Salzman is credited with a breakthrough discovery in cellular DNA repair, which led to the world’s first clinical application for successfully treating breast cancer caused by mutations in BRCA1 and BRCA2 genes. Millions of patients are benefiting from discoveries by Dr. Salzman in areas including mitochondrial health, gastrointestinal microbiota, damage caused by inflammation and oxidative stress to human cells and DNA, autoimmune disease, and cancer.

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Did you know that what you eat could significantly affect your ability to have children? In this episode, I’m demystifying the vital connection between fertility and nutrition, discussing how diet influences DNA, cellular health, and reproductive wellness. Tune in to discover how avoiding ultra-processed foods and incorporating key nutrients can improve your fertility outcomes and overall health.

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Dementia and Alzheimer’s are rising at an alarming rate, affecting millions worldwide and costing trillions in healthcare. In this episode of “The Doctor’s Farmacy,” I sit down with Dr. Heather Sandison to explore groundbreaking personalized treatment approaches that offer hope in reversing cognitive decline. Learn more about the impact of lifestyle interventions, the role of environmental toxins, and the power of holistic methods compared to conventional treatments.

In this episode, we discuss:

• The rising prevalence of Dementia and Alzheimer's
• The importance of personalized treatment plans for cognitive decline
• The critical role of lifestyle interventions, including diet, exercise, sleep, and stress management, in reversing cognitive decline.
• How toxins, such as heavy metals and mold exposure, contribute to cognitive decline
• The advancements in diagnostics, including more accurate and early detection methods for dementia and Alzheimer’s
• How cognitive decline and dementia can be reversed through a multifaceted approach

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This episode is brought to you by Rupa Health, BIOptimizers, LMNT, Cymbiotika.

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Testosterone levels in men have dropped significantly over the past few decades and in this episode of "The Doctor’s Farmacy," we’ll uncover some of the reasons why. Dr. George Papanicolaou joins me to discuss the critical role testosterone plays in metabolic health and overall well-being. We dive into how low testosterone levels can impact everything from muscle mass to blood sugar control, and discuss the best methods for measuring and optimizing hormone levels. 

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Full-length episodes of these interviews can be found here:

Are Your Hormones Out Of Balance? | Know Your Numbers

Male Menopause, Low Libido and Testosterone Replacement

Fertility in Crisis: Exploring the Toxic Threats to Fertility and the Rise in Infertility

This episode is brought to you by Mitopure, Butcher Box, Purity Coffee, and Armra.

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I always say I want to live to be 120 years old, but feeling strong and healthy as I age is even more important to me. In this episode of “The Doctor’s Farmacy,” I delve into the intricate relationship between inflammation and aging, emphasizing the difference between lifespan and health span. I’m breaking down everything you need to know about the gut microbiome, inflammatory triggers, and effective strategies to reduce inflammation. Plus, I’ll share some practical tips on optimizing your diet and supplements to support your body's natural detoxification processes.

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Our current food system is a national emergency. It’s intricately designed to confuse and mislead consumers, making healthy choices difficult and contributing to America’s chronic disease epidemic. In this episode, I sit down with Senator Cory Booker to delve into the systemic issues impacting our diet, food labeling, and the power of policy change. 

In this episode, we discuss:

• How food packaging is designed to confuse or mislead consumers
• The link between the food system, chronic illness, and the unintended consequences of food policies that increase disease and healthcare costs.
• The harmful effects of ultra-processed foods
• The negative impact of industrial farming practices on the environment, soil health, and the nutritional quality of food
• The importance of personal health advocacy and broader public health initiatives to transform the food system, improve health outcomes, and reduce healthcare costs

Uncover the truth behind our food politics and discover how informed choices can lead to a healthier future. This conversation was hosted by Sixth and I in Washington, DC.

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Millions of women experience hormonal imbalances at some point in their lives, but did you know suffering isn’t your only option? In this episode of “The Doctor’s Farmacy,” I look back on conversations with Dr. Mindy Pelz and Dr. Elizabeth Boham where we explore the complexities of hormone health. From the benefits of bioidentical hormones versus synthetic ones to the impact of diet, exercise, and stress management on hormone balance, learn how functional medicine tailors personalized treatments to enhance your overall well-being.

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This episode is brought to you by Mitopure, Happy Egg, and Cymbiotika.

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The perfect diet isn't always enough – sometimes we need a little help from supplements to feel our very best. On today’s episode of “The Doctor’s Farmacy,” I’m giving you the ultimate supplement stack to complement your wellness routine so you can live better. We’ll cover the basics from multivitamins to probiotics and discuss why personalized testing is key to getting it right. Let’s explore how to effectively use supplements to bridge the nutritional gaps in your diet.

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This episode is brought to you by Mitopure, Fatty15, and SleepMe.

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Everyday exposure to toxins are silently wreaking havoc on our well-being, causing a surge in chronic diseases and health complications. In this episode, I'm joined by Dr. Joseph Pizzorno to dive deep into the hidden dangers of environmental toxins. Learn about practical detoxification pathways, foods that support detox, and effective methods like sweating to eliminate fat-soluble toxins. Plus, discover how reducing your exposure to heavy metals and synthetic chemicals can dramatically improve your health.

In this episode, we discuss:

• The startling link between lead exposure and cardiovascular disease
• Persistent organic pollutants found in everyday items
• The impact of heavy metals on prostate cancer, heart disease, and diabetes
• How increased fiber intake helps eliminate toxins by preventing reabsorption in the gut
• How regular sauna use can help eliminate toxins that are difficult to remove through other means

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This episode is brought to you by Rupa Health, Pendulum, Armra, and Purity Coffee.

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Did you know chronic loneliness is just as harmful as smoking 15 cigarettes a day? In this episode, I revisit conversations with Dr. Vivek Murthy and Dr. Robert Waldinger to explore the profound impact of social isolation on both our physical and mental health. Plus, we share practical tips for cultivating connections in our modern world where loneliness is increasingly common.

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Full-length episodes of these interviews can be found here:

The Surprising Key to Longevity

Why Loneliness Is A Public Health Issue

How Our Relationships Can Impact Our Health And Longevity

This episode is brought to you by Momentous, Neurohacker, AG1, and Cymbiotika.

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Did you know that what you eat and the toxins in your environment can significantly influence your risk of developing cancer? In this episode, I’m tackling a major concern that's been making headlines: the dramatic rise in cancer among young people. We'll explore the root causes, from chronic inflammation and insulin resistance to lifestyle and dietary choices that are actively impacting your wellbeing. Join me as I provide research-backed solutions and practical strategies to help you reduce your cancer risk and improve your overall health.

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This episode is brought to you by AG1, Our Place, and Happy Egg.

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Believe it or not, data can empower you to live a longer, happier, and healthier life. In this episode, I’m joined by Bryan Johnson, a health optimization pioneer. Bryan shares his meticulous approach to tracking and measuring every aspect of his health to make informed lifestyle choices. We break down his structured diet, supplement regimen, and sleep optimization techniques, all designed to enhance longevity and well-being. 

In this episode, we discuss:

• The importance of rigorous measurement and data-driven interventions to optimize health
• Maximizing nutrient density and minimizing unnecessary calories
• How chronic inflammation and insulin resistance drive disease and accelerate aging
• The Blueprint program, a systematic approach to health optimization that others can follow, incorporating diet, exercise, sleep, and supplements

Don’t miss our fascinating discussion of the “don’t die” philosophy and how it could revolutionize our approach to health and aging.

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Uncover the secrets to a longer, healthier life by understanding the impact of nutrient sensing pathways with guest Radha Agrawal and me. Today, we’re exploring the dangers of ultra-processed foods, the benefits of regular exercise, and the power of a strong social network. Plus, I'll give you my top three tips for boosting longevity and preventing chronic diseases.

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This episode is brought to you by Rupa Health, Cozy Earth, Cymbiotika, and Mitopure.

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Have you ever wondered why you constantly feel tired, achy, or bloated? In this episode, I delve into "Feel Like Crap Syndrome," a term I coined to describe the chronic low-level systemic inflammation that affects so many of us. I’ll share my clinical insights on how ultra-processed foods and other dietary choices may explain why you’re feeling so run down. Plus, find out how a 10-day elimination diet can help you reset your health and live your best life.

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This episode is brought to you by Rupa University, House of Macadamias, and SleepMe.

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What if we could predict diseases before they occur? Dr. Leroy Hood joins me on this episode of “The Doctor’s Farmacy” to shed light on the future of brain health and scientific wellness. We examine the crucial role of regular exercise and diet in maintaining brain health, and how early detection methods like metabolic PET scans can identify changes in brain metabolism years before symptoms of disease appear. 

In this episode, we discuss:

• The significance of tracking biomarkers to understand what's happening inside the body and how it relates to health and disease.
• How big data and AI are transforming medicine by enabling highly personalized care through tools like knowledge graphs, digital twins, and machine learning.
• The concept of biological age as a metric for wellness, with the potential to reverse biological aging through personalized health interventions.
• Tom Brady's use of Brain HQ to improve his reaction time and depth of field, showcasing the practical benefits of cognitive training.

Don’t miss our conversation on groundbreaking advancements in personalized healthcare, including how phenomics, AI, and brain health innovations can transform your wellness journey.

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Did you know that the food you eat can actually change your genes and improve your health? In this episode, I speak with Dr. William Li and Dr. Jeffrey Bland about how the quality of our food significantly impacts our health. We dive into the fascinating world of phytochemicals, exploring how foods like konjac root, cruciferous vegetables, and medicinal mushrooms can enhance our well-being and even reverse chronic diseases like diabetes and heart disease. Learn all about the transformative potential of food and how you can harness it to feel your best.

This episode is brought to you by Rupa Health, Mitopure, and AG1.

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Struggling with PMS symptoms like mood swings, cramps, and bloating? It doesn’t have to be this way! In this episode of “The Doctor’s Farmacy,” I’ll break down how diet, inflammation, and nutrient deficiencies can throw your hormones out of whack and I’ll share simple, effective changes you can make to feel better. From cutting back on sugar and caffeine, to adding anti-inflammatory foods and key supplements, discover how to balance your hormones naturally and finally find relief from PMS.

This episode is brought to you by Rupa Health, AG1, and Thrive Market.

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Peptides are gaining popularity for their remarkable health benefits, but what exactly are they and how can they help you? In this episode of “The Doctor’s Farmacy,” I sit down with Dr. Edwin Lee to demystify the incredible world of peptides. We delve into how these tiny proteins can regulate every function in your body, from hormone imbalance to tissue repair, and even cognitive health. 

In this episode, we discuss:

• The crucial role peptides play in regulating our wellbeing
• BPC 157, a peptide that shows promise in accelerating healing from injuries and reducing inflammation
• Epi-thalon, a peptide with potential to improve sleep quality and reverse some aging markers
• The future potential of peptides, including ongoing research and clinical trials, to unlock further therapeutic uses and improve patient outcomes
• The importance of using peptides under proper medical guidance to ensure safety and efficacy

Learn how peptides can optimize your overall health and longevity, and why they might just be the future of medicine.

This episode is brought to you by Rupa University, Cozy Earth, LMNT, and Cymbiotika.

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AI is set to revolutionize healthcare as we know it - improving diagnostics, treatment personalization, patient care, while simultaneously reducing costs and enhancing outcomes. In this episode of “The Doctor’s Farmacy,” I sit down with Vijay Pande, PhD and Daisy Wolf, JD to explore how investors are shaping the future by funding innovative companies that address our system's fundamental problems. Discover how cutting-edge tech, like wearable devices and AI diagnostics, is making personalized medicine more accessible and effective for everyone.

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Over 75% of adults and 40% of kids in the U.S. are now overweight - and sugar addiction is a big reason why. In this episode, discover how sugar hides in many common foods like salad dressings, sauces, and pasta sauces. We'll explore how excessive sugar drives obesity, diabetes, cognitive decline, depression, and even Alzheimer's disease. Plus, I'll share my 10-day detox diet designed to help you break free from sugar addiction and transform your health.

This episode is brought to you by AG1, Our Place, and House of Macadamias.

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Imagine if you could turn back the clock on your immune system and make it work like it did when you were younger. In this episode of “The Doctor’s Farmacy,” I'm thrilled to welcome Dr. Jeffrey Bland to dive into the exciting world of immuno-rejuvenation. We explore the cutting-edge science behind phytochemicals and their incredible ability to influence gene expression and supercharge our immune health. 

In this episode, we discuss:

• Revitalizing and enhancing the immune system to function more efficiently
• The science behind how certain natural compounds can influence gene expression and boost immune health.
• Practical steps to incorporate specific nutrients and compounds into your diet to decrease inflammation.
• The importance of gut health and its connection to chronic diseases and mental health.

Join us as we lay out practical tips to easily incorporate these powerful nutrients into your diet for a healthier, more resilient you.

This episode is brought to you by Rupa Health, Pendulum, BIOptimizers, Armra.

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Food is more than just fuel - every bite we take has a profound impact on our biology. In this episode, I explain the principles of the Pegan diet, emphasizing the importance of quality, nutrient-dense foods. Joining me are some incredible guests: Dr. Cindy Geyer, a renowned expert in functional medicine, and Dr. Elissa Epel, a leading stress researcher. Together, we'll explore how chronic stress and poor sleep are intricately connected to major health issues like obesity, diabetes, and neurodegenerative diseases. Learn how specific dietary choices can serve as powerful medicine, improving your overall health and longevity. Plus, explore actionable tips and expert insights on integrating these health-boosting foods into your daily routine.

This episode is brought to you by Rupa Health, Neurohacker, and Cymbiotika.

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Harness the power of nutrition for a healthier, sharper mind. In this episode of "The Doctor's Farmacy," I explore the science behind five remarkable superfoods that can sharpen your mental acuity, rejuvenate your brain, and safeguard against neurodegenerative diseases. Plus, I share actionable tips to seamlessly integrate these brain-boosting foods into your daily diet, enhancing your cognitive function and overall well-being.

This episode is brought to you by Rupa University, Essentia, and Momentous.

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Approximately 1 in 5 women over the age of 65 are affected by Alzheimer's, yet research on this condition often neglects to address the specific impact it has on women's health. Renowned journalist and women's health advocate Maria Shriver joins me on this enlightening episode of "The Doctor's Farmacy" to examine the critical connection between diet, brain health, and longevity. Maria shares personal insights into her family's health journey and her tireless efforts to raise awareness about women's health disparities. 

In this episode, we discuss:

• The impact of diet on brain health
• The importance of comprehensive diagnostics
• Empowering patients by giving them more hands-on access to their health data
• The disparities in women's health coverage

Join us for a thought-provoking discussion on equipping individuals with the tools and knowledge needed to take control of their health journey.

This episode is brought to you by Rupa Health, Butcher Box, Thrive Market, and Mitopure.

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Got milk? Well, you might want to reconsider that after listening to this episode. I explore the truth about milk with Dr. David Ludwig, including its nutritional value, health risks, and the impact of modern dairy farming practices. Together, we challenge the conventional wisdom that promotes high dairy intake and we discuss the latest scientific research that questions its necessity and safety. You'll gain a deeper understanding of how dairy affects your health and what alternatives might be better for your diet.

This episode is brought to you by Rupa Health, AG1, and Cymbiotika.

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Why is it so hard to lose weight and keep it off? On this episode of "The Doctor's Farmacy," we explore the intricate science of weight gain and metabolism, debunking common myths about calorie counting and your diet. Emphasizing the importance of food quality over quantity, I'll examine how modern diets high in refined carbs and sugars contribute to obesity. By investigating root causes and offering a holistic approach, I’ll provide you with a science-backed roadmap to achieving sustainable weight loss and optimal metabolic health.

This episode is brought to you by AG1 and Fatty 15.

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Approximately 1.2 million Americans are diagnosed with diabetes each year​. Understanding the complex nature of this disease is crucial to tackling this widespread health issue. Award-winning science and health journalist Gary Taubes joins me to delve into the history of diabetes and modern treatment options. Together, we explore the use of ketogenic diets, the impact of drugs like Ozempic, and the need to reassess our approach to diabetes management. 

In this episode, we discuss:

• The evolution of diabetes treatment
• Assumptions about diabetes and the influence of dietary choices
• The role of calorie intake and exercise in diabetes management
• The limitations of current drugs used to treat diabetes
• Clinical trials and their impact on our understanding of diet and health
• The choice between drug therapy and dietary changes in managing diabetes

Join us to discover how bias and ingrained beliefs can obstruct progress in understanding how to treat this chronic illness.

This episode is brought to you by Rupa Health, Pique, and BIOptimizers. 

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Metabolic health is key to preventing chronic diseases, which means it’s crucial for us to understand how our dietary choices impact our overall wellbeing. Simple changes in our eating habits can improve our insulin response and balance blood sugar levels, which offers immediate health benefits. In this episode, Jessie Inchauspe, Dr. Casey Means, and Dr. Ben Bikman share their actionable insights on boosting your metabolism through food. We delve into the latest research and provide practical tips for incorporating metabolism-friendly nutrition into your daily routine.

This episode is brought to you by Rupa Health, Cozy Earth, Cymbiotika, and Momentous.

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Microplastics, tiny pollutants that infiltrate our environment, are known to have serious implications on our health and ecosystems. In today's episode, we explore how microplastics contribute to conditions like obesity and cancer and we identify the top sources of exposure. Listen now for practical steps to detoxify your body and reduce microplastic exposure in your everyday life.

This episode is brought to you by AG1, Neurohacker, and Cymbiotika.

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The world is experiencing a mental health crisis like never before. While that is rightfully scary, it’s important to recognize that many of our daily choices can up-level our brain function and mental health. The inadequacies of current psychiatric disease and care models require urgent attention to address root causes such as nutrition, toxins, and gut health. In this episode of the podcast, I talk to Dr. James Greenblatt, who draws on his four decades of experience in studying functional psychiatry to highlight the importance of a personalized approach to mental health. 

In this episode, we specifically focus on: 

• The pressing need for a new model of mental health care.
• How is functional psychiatry different from conventional psychiatry? 
• Root causes of mental health issues and the importance of addressing nutrient deficiencies, toxins, and gut health.
• Success stories using the personalized approach with low-dose lithium, ketogenic diets, and nutraceuticals to treat psychiatric symptoms. 
• Encouragement for those suffering from mental health disorders to explore Functional Medicine approaches.
• Integrating Functional Medicine principles into mainstream psychiatry.

Join us to discover how Functional Medicine can transform mental health care and offer new hope for those struggling with mental health disorders.

This episode is brought to you by Rupa Health, Mitopure, House of Macadamias, and Cymbiotika.

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We often hear about food in the context of physical health, but food is very tied to emotional and mental health, too. The growing field of nutritional psychiatry is shedding light on this profound connection between food and mood, and how what we eat impacts everything from anxiety and depression to ADHD and more.

In this episode, Dr. Hyman speaks with Max Lugavere and Dr. Uma Naidoo about the best foods to eat to support your brain and the beautiful symphony between what you eat, your gut microbiome, and cognitive function.

This episode is brought to you by Rupa University, ButcherBox, and Cymbiotika.

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Every year, we celebrate our birthdays, marking another year of growing older and, hopefully, wiser. But what if we flipped the script and celebrated getting younger instead? 

With groundbreaking advancements in longevity science and technology, this idea is becoming more than just a dream. We now have the tools, diet, lifestyle, and supplement regimens to reverse our biological clock.

In today’s episode, we’ll dive into the science behind what ages us, the latest research breakthroughs in eating and aging, and we’ll uncover how our diet and lifestyle impact our bodies at the genetic level, influencing DNA expression and potentially switching off our aging genes. Stay tuned until the end for my six-step actionable protocol to start aging in reverse!

This episode is brought to you by Rupa Health, Essentia, and House of Macadamias. 

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We live in a time with more money, medical interventions, and knowledge than ever before—so why are we getting sicker? While this might seem depressing, there are actually many exciting discoveries changing the future of wellness, like our increased understanding of the microbiome and how it interacts with the brain. This dynamic has profound implications for mental health, reducing the risk of neurodegenerative diseases, and even supporting positive behavior in our children. I’m excited to talk to board-certified internal medicine physician, bestselling author, and published researcher Dr. Austin Perlmutter about all this and more on this episode of the podcast. 

We explore:

• Why don’t we try to prevent brain dysfunction the same way we do cardiovascular disease and other illnesses?
• Neuroinflammation and how to modulate it to improve mood, behavior, and neurodegenerative diseases
• Having an “adult in the room” versus our lizard brain
• The inundation of Big Food and Big Pharma marketing we’re up against
• Psychobiotics: The future of probiotics for brain health 

I know you’ll love this conversation as much as I did. I hope you’ll tune in wherever you listen to podcasts!

This episode is brought to you by Rupa Health, Magnesium Breakthrough, LMNT, and Pique. 

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Lifestyle and dietary factors are widely accepted as key drivers of disease among cardiologists, oncologists, and endocrinologists, however the impact of diet and lifestyle on our brain health still remains largely on the margins. And, while there are certainly other factors, creating healthy daily habits can make a significant difference.

In this episode, Dr. Hyman speaks with Dr. Marwan Sabbagh, Dr. Richard Isaacson, and Dr. Jay Lombard about the role of genetics in brain disorders, lifestyle habits you can start right now to reduce your risk or reverse symptoms, and why we need to look at bacteria as a cause of neurodegenerative disease.

This episode is brought to you by Rupa Health and AG1.

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There’s a common misconception that getting older means getting weaker, but what if you could improve your fitness level at any age? The truth is, you can. 

In today’s Health Bites episode, I’m joined by my dear friend and colleague, Dr. George Papanicolaou, a highly sought-after Functional Medicine practitioner on my team at the Ultra Wellness Center. Together, we explore the incredible benefits of exercise—a free, universally accessible powerhouse drug—from a functional medicine perspective. 

We discuss the crucial, often-overlooked aspects of fitness for enhancing longevity, such as VO2 max, how to optimize our levels, and the role our mitochondria play. We also dive into the importance of resistance training and nutrition for enhancing body composition, strength, and muscle mass, vital for metabolic health, recovery from illness, and so much more.

If you’re looking to leverage your exercise routine to enhance your overall health and quality of life, no matter your age, this episode is for you. 

This episode is brought to you by AG1, Neurohacker, and Cymbiotika

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One of the many reasons I was drawn to Functional Medicine is that it’s the medicine of asking “why?” and looking beyond the status quo to reimagine health. When we use this practice to assess the metabolic diseases we see today, we can see we’re in an energy crisis. We’re wrapped up in a web of physiologic root causes, but also a web of policies, industries, and economic incentives impacting our health from the ground up. I loved discussing all this and more on this episode of the podcast with Dr. Casey Means. 

We take a deep dive into:

• Why we need to reimagine the healthcare system and how to use Functional Medicine as a framework for asking “why?”
• Using metabolic health as a barometer for our challenges as a society 
• A stark reality: Every institution related to our health makes money off of sickness
• Combining advanced technology with our own awareness to take back control of our health
• Five affordable biomarkers of metabolic syndrome to start with 
• And so much more!

I hope you’ll tune in to learn how to dramatically improve your metabolic health and support foundational societal shifts, all at once.

This episode is brought to you by Rupa Health, ARMRA Colostrum, Pendulum, Live Momentous, and House of Macadamias.

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Our brain has the ability to adapt, change, and grow new neurons through a concept known as neuroplasticity. Compounds in psychedelics are finally being recognized as powerful tools to change the wiring of the brain which means we’re not doomed to become a statistic and lose our minds as we get older or carry destructive trauma in our bodies for the rest of our lives. 

In this episode, Dr. Hyman speaks with Dr. Andrew Huberman, Dr. Sara Gottfried, and Paul Stamets about what exactly neuroplasticity is and how psychedelics like ketamine and psilocybin may be a helpful treatment for depression, trauma, addiction, and more.

This episode is brought to you by Rupa Health, Cozy Earth, and Cymbiotika.

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Carrying excess weight around your midsection can be frustrating, especially if you maintain a healthy diet and exercise regularly. Yet, millions of people worldwide struggle with their weight, 

It is crucial to understand that belly fat is more than just a layer under your clothes. It is an active endocrine organ that secretes pro-inflammatory cytokines throughout the body, contributing to our risk for chronic diseases.

It's important to recognize that this is not a reflection of personal failure. Our modern-day lifestyles are overloaded with stress, environmental toxins, and convenience foods that actively work against us. In today’s episode, we will explore visceral fat (a.k.a. belly fat), the factors that contribute to it, and how to address it using the principles of Functional Medicine effectively.

In this episode, I dive into:

• Understanding belly fat and obesity (2:51) 
• The role of diet and lifestyle in the accumulation of belly fat (10:48) 
• The impact of sleep, alcohol, and stress on weight gain (19:14) 
• What are obesogens, and how do they make us gain weight? (21:44)
• Health risks associated with visceral fat and belly fat (23:05) 
• Where does conventional medicine miss the mark? (24:14)
• Functional medicine's approach to assessing and addressing visceral fat (26:38) 
• Dietary and lifestyle changes to reduce visceral fat (30:52) 

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Every parent wants to raise a healthy kid, but our modern world, industrialized diet, and increased stressors can make that goal feel confusing and difficult. The good news is that we can do so many things during a child’s life, and even before it starts, to give them the best possible chance to truly thrive in body and mind. I’m thrilled to share this in-depth conversation with pediatric Functional Medicine expert, and mom to 2 thriving children, Dr. Elisa Song.

In this episode, we discuss:

• The disappearing act of Bifidobacterium infantis and why it matters 
• Why preconception support is so important for optimal epigenetic programming 
• The bloodwork Dr. Song runs when first assessing a child 
• One nutrient that might dramatically help your sensory-sensitive child
• A grounded discussion around the controversial topic of vaccines
• And so much more!

No matter how old your kids are, it’s never too late to upgrade their health with holistic approaches. I know you’ll love this episode as much as I did!

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A declining mind is one of the scariest things we can imagine. Yet, many of us walk around every day with brain fog, which is a clue that our brains (and our bodies) need some support. Left unchecked, there can be long-term consequences, and not just for your brain. The good news is that changes to diet, reducing toxic burden and stress, improving sleep and gut health, and getting good movement can work wonders to clear up any fogginess.

In this episode, Dr. Hyman speaks with Dr. Todd LePine and Max Lugavere about the Functional Medicine approach to reducing brain fog.

This episode is brought to you by Rupa Health, AG1, and Cymbiotika.

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Excess sugar consumption is one of the deadliest drugs of our time, and it’s virtually ubiquitous in our modern-day industrialized food system. Everywhere you turn, there’s sugar—from blended coffees to protein bars, drinks, dressings, snacks, and everything in between. Even seemingly “healthy” packaged foods often contain heaps of added sugar, and its impact has proven catastrophic for our mental and metabolic health.

As the other white powder, sugar hijacks our brain chemistry, making us addicted, inflamed, sick, and depressed. But the good news is that most of the health issues that arise from eating too much sugar can be completely reversed in as little as 14 days.

In today’s Health Bites episode, we’re exploring the research connecting sugar addiction to poor mental health and what you can do to clean up the excess sugar to reclaim your health and feel better, and more energized.

In this episode, I discuss:

• The prevalence of sugar in our diet and its impact on mental health (2:00)
• Hidden sources of sugar in our diets (7:27)
• How sugar affects our mood and brain function (11:42)
• How insulin resistance leads to systemic inflammation and changes in mood (16:16)
• Strategies to reduce sugar intake for better mental health (20:41)
• The role of supplements, exercise, stress, and sleep in blood sugar management (26:40)

This episode is brought to you by Cozy Earth and Fatty 15.

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Each bite of food we eat has the potential to modulate our genetics and impact every cell of the body—don’t you want those levers to be moving in the right direction? Eating for health is one thing, but eating to beat disease is an even more intentional step toward prevention and longevity. I was so excited to sit down with internationally renowned physician, scientist, and author Dr. William Li to discuss how we can leverage food to optimize every system of the body. 

We dig into:

• How Dr. Li got interested in “Food As Medicine” while developing cancer treatments 
• Why eating to beat disease is not the same as eating for health
• What food would Dr. Li bring with him if he was going to be stuck on an island?
• One thing Dr. Li knows everyone needs to do better
• Is dairy good or bad?
• What’s the deal with soy? 
• The 5 defense systems to support optimal health and Dr. Li’s 5 x 5 x 5 plan 

We talk about this and so much more. I know you’ll love this conversation as much as I did!

This episode is brought to you by Rupa Health, BIOptimizers, Timeline Nutrition, and Momentous.

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Your gut microbiome is your inner garden—the more good bugs you have in it, the more likely it is to flourish. Our gut bacteria regulate many bodily functions, from creating vitamins to controlling our immune system, brain function, and, of course, our metabolism and weight. 

In this episode, Dr. Hyman speaks with Dr. Elizabeth Boham and Shawn Stevenson about the ways in which our gut influences the health of our body, and alternately, how our lifestyle choices affect our gut health.

This episode is brought to you by Rupa University, AG1, and OneSkin.

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Infertility is a significant challenge for many couples, with statistics now showing that one in six couples face difficulties conceiving. What was previously perceived primarily as a woman's issue is now recognized as a shared concern between partners. In today’s episode, we'll explore the factors in our modern environment contributing to this growing problem.

In this episode, we’ll explore what’s driving this infertility epidemic and a step-by-step Functional Medicine protocol for correcting hormonal imbalances and elevating overall health through targeted dietary choices, lifestyle changes, and the strategic use of supplements. Tune in for a comprehensive approach to addressing infertility from the inside out.

In this episode, I discuss:

• The fertility crisis (4:03)
• Top drivers of the global decline in fertility (7:01)
• How sugar can cause hormonal imbalances (7:36)
• Chronic inflammation and trouble conceiving (9:46)
• The role of the gut microbiome (12:50)
• Conventional Medicine fails to get to the root cause of infertility (17:12)
• The Functional Medicine approach to infertility (19:33)
• The importance of testing and correcting nutrient deficiencies (20:21)
• Hormones to test and why (26:59)
• Step-by-step protocol to support fertility (34:32)
• Choosing the right prenatal supplement (44:59)

This episode is brought to you by AG1, Momentous, and Cymbiotika.

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Food has become a more complex part of our lives than ever before. Much of what we think is food is actually many ingredients disguised as food, with entirely different, often negative impacts on the human body. Sadly, this is a greater problem here in the US than in other parts of the world, thanks to the food industry, corrupt intentions, and broken policies. Today, I talk about all this and more with my guest Jason Karp, whose personal experience of nearly going blind due to a toxic lifestyle led him to discover a different way; he made it his mission to get “back to human.”

In this episode, we discuss:

• Jason’s personal health journey and why that has prompted him to take on the campaign against Kellogg’s (7:53)
• The unhealthy state of America’s food industry (22:42)
• How Kellogg’s has one cereal formulation for Canada and another for the US that is full of chemicals (26:07)
• The correlation between food dyes and ADHD, and the failure of Kellogg's pledge (29:04)
• The political aspect of food regulation and dangers of unregulated food additives (32:55)
• Why we are in a state of metacrisis and what that means for our future (37:18)
• The bidirectional relationship between food and mental health (46:04)
• The financial burden of healthcare on the US government due to unhealthy diets (53:52)
• Supporting the Kellogg's Initiative: Sign the Petition (1:06:03)
• 
  

We have a lot to do to shift our food system and eliminate harmful ingredients in the US, but there are ways to enact positive change starting today. We can all support a cleaner food industry and better health by voting with our dollar, purchasing real food, and getting involved in policy policy changes. I hope you’ll listen to this episode to learn more. 

This episode is brought to you by Rupa Health, Cozy Earth, BIOptimizers, and Wonderfeel. 

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Obesity rates are at an all-time high, even in our children, despite the common recommendation to eat less and exercise more. While calories may be one piece of the puzzle, weight is so much more nuanced than that including factors such as mother’s metabolic health during pregnancy, chemicals called obesogens, inflammation, hormones, and more.

In this episode, Dr. Hyman speaks with Dr. Elizabeth Boham, Calley Means, and Dr. Casey Means about the obesity crisis, how we got here, and what we can do about it.

This episode is brought to you by Rupa Health, ButcherBox and Mitopure.

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I'm turning 65 this year and feel younger, fitter, and more vibrant than ever. Thanks to my longevity routine, I’ve been able to reverse my biological age by 20 years, plus an additional year in the past five months alone!

As I grow older, I’ve learned that what’s possible when we nourish our bodies, get regular exercise, quality sleep, and manage our stress – we can effectively turn back our biological clock. Add a supplement stack and hormetic stressors to activate our longevity switches, and you’re setting a solid foundation for lasting health. So, how does someone in their 60s build muscle and sport abs that could rival their younger selves? 

In today’s Health Bites episode, I’m sharing the exclusive details behind my longevity routine that anyone can try on their journey towards a healthier, longer life. Whether you want to sharpen your mind, enhance your physique, or simply feel younger, this episode is for you. Remember, it’s not just about adding years to your life, but life to your years. 

In this episode, I discuss:

• My morning routine for longevity (2:46)
• How I get the benefits of exercise in minimal time (3:23)
• A look at the ingredients in my Healthy Aging Shake (5:54)
• What I eat in a day (lunch and dinner) to support longevity (11:46)
• The role of dietary protein for longevity and how much to eat every day(15:03)
• How to activate your longevity switches using the power of hormesis (23:00)
• Top tips for active relaxation and rejuvenation (28:51)
• My nightly routine for sleep optimization (30:01)
• The supplement I take for optimal health and longevity (32:01)
• Why lab testing is crucial for longevity and optimal health (33:31)
• Personal experience and experimentation with advanced longevity therapeutics (36:55)

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Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails. Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between. 

In this episode, we discuss:

• The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34)
• Challenging the notion of treating obesity with drugs like Ozempic (10:35)
• An unsettling revelation about the push for using Ozempic in children (12:04)
• Digging deeper into GLP-1 research and some of the benefits (32:51)
• Why are children being born metabolically challenged? (41:11)
• Dr. Moore’s approach to using peptides with her patients and for her own crippling pain, and what they’ve seen (45:19)
• How our current healthcare system lacks policies and support for behavior change (1:27)

While there are always differing views, we know for sure that our food and drug policies aren’t serving the best interests of creating sustainable, empowered health for the masses. I hope you’ll tune in to hear more from this comprehensive and lively discussion. 

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Gas, bloating, constipation, diarrhea, urgency, and painful cramping—these are just some of the many difficult symptoms that come along with inflammatory bowel disease, also known as IBD. This disorder is an umbrella term for a variety of symptoms and diagnoses, including ulcerative colitis and Crohn’s disease, and it impacts millions of Americans each day.

In this episode, Dr. Hyman speaks with Dr. George Papanicolaou, Dr. Miguel Reguiro, and Dr. Shilpa Ravella about the Functional Medicine approach to reducing symptoms of IBD that extend beyond medications and surgery.

This episode is brought to you by Rupa Health and LMNT.

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In the health space, we hear the term ultra-processed foods thrown around often for its clear link to chronic diseases such as depression, Alzheimer’s, and diabesity. But what exactly does “ultra-processed” mean? How can you tell if a food is ultra-processed?

In today’s Health Bites episode, we will learn exactly what ultra-processed foods are, how to identify them, their impact on human health, and the global economy. We’ll also discuss tips and tricks for how to read food labels to better navigate the grocery store, and the innovations happening in Washington to develop label laws that helps protect the consumer.

In this episode, I discuss:

• Definition, examples, and deceptive health claims of ultra-processed food (2:06) 
• Health risks and impacts of ultra-processed food (7:30) 
• Case study: impact of an ultra-processed diet on twin girls (10:00) 
• History and rise of processed food (12:09) 
• Difference between ultra-processed and minimally processed foods (17:45) 
• Impact of food packaging and additives on health (24:01) 
• Economic and societal consequences of chronic diseases caused by poor diet (28:04) 
• Identifying ultra-processed foods and understanding food labeling (35:00) 
• Avoiding ultra-processed foods and using food scoring systems (40:50) 

This episode is brought to you by Rupa Health, Essentia, and Cymbiotika.

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The prevalence of autism has risen a shocking 400% in the last twenty years. Increased awareness and diagnosis are one piece, but there are also so many other factors to consider. The hopeful news is that we’re seeing a shift paradigm in how we view and treat autism, with some truly amazing improvements possible. I’m thrilled to welcome Dr. Suzanna Goh, a board-certified pediatric behavioral neurologist, behavioral analyst, neuroscience researcher, Rhodes scholar, and author.

In this episode, we discuss:

• Shaking things up around the autism paradigm (1:57)
• The connection between the brain and mitochondria (6:04)
• Can autism be reversed? (7:00)
• The biggest mistake made in autism (10:10)
• What creates the inflammatory fire in the autistic brain? (15:20)
• The role of diet in autism treatment (19:17)
• Functional tests for assessing brain function and how to best support kids with autism (26:30)
• Mitochondrial dysfunction and autism (28:30)
• "Magnificent Minds" - A book on autism by Dr. Suzanne Goh (34:57)

Using a whole-child approach and investigating the intricate connections between metabolism, mitochondrial function, and nutrition we can better understand what types of support autistic children need most. I hope you’ll listen in to learn more. 

This episode is brought to you by Rupa Health, AG1, and Essentia.

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Often, when patients have high cholesterol or high blood pressure, the treatment focus is on statins or anti-hypertensive medications. However, these are just the symptoms of poor metabolic health, which requires a closer look at the root cause and a treatment model that reflects that.

In this episode, Dr. Hyman speaks with Dr. Elizabeth Boham and Dr. George Papanicolaou about our lifestyle choices that affect our cholesterol levels, blood pressure, and waist circumference.

This episode is brought to you by Rupa University, AG1, and Momentous.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

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Our global mental health crisis is growing at an exponential rate, with over half a billion people suffering from depression and anxiety; it’s time we rethink our understanding of the underlying root causes of mental health challenges.

From treating thousands of patients, I’ve learned that depression is not in your head. It’s in your body. More specifically, your gut. When your gut is unhealthy and inflamed, your brain is unhealthy and inflamed. In Functional Medicine, we know that the gut and the brain are intimately connected and that the health of one directly influences the health of the other. 

In today’s Health Bites episode, we’re diving into the gut-brain connection and sharing Functional Medicine tools to support your gut health and, as a result, your mood and mental health. 

In this episode, I discuss:

• Our global mental health crisis (2:45)
• The gut-brain connection (4:18)
• The story of Marks's broken brain (5:15)
• Features of the gut-brain axis (8:57)
• Gut hormones that send signals to your brain (10:06)
• Role of the gut microbiota in mood and mental health (12:24)
• How stress negatively impacts our gut microbiome (20:14)
• The link between leaky gut and poor mental health (21:41)
• The Functional Medicine approach to fixing the gut (25:56)
• The 5R Program for fixing your gut health (30:09)

This episode is brought to you by AG1 and Rupa Health.

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Functional Medicine offers patients many things, especially hope and understanding. Autoimmune disease is a prime example: Rather than condemning patients to a lifetime of symptom management through medication, functional practitioners dig to find the “why,” to address the underlying causes with individualized, multimodal support to create lasting improvement and systemic healing. My guest today, Dr. Sara Gottfried, is a physician, researcher, author, and educator passionate about changing the way we view and treat autoimmunity. 

In this episode, we discuss:

• What is a “trauma signature” and what is its role in autoimmunity? (5:55)
• Hidden autoimmunity triggers you might be surprised to learn about (21:30)
• The go-to test panel Sara runs on her patients (27:33)
• Sara’s stack for reducing cortisol and why trauma has to be considered (39:00)
• How Trauma biologically impacts you through the PINE system (41:40)
• Psychedelic therapy and other healing states of consciousness, plus Sara’s personal experience using them (48:10)
• What Sara wishes she told her 20-year-old self about life (1:15:45)

When we dig deeper, we always find out there is more going on below the surface. I know you’ll love this conversation as much as I did. 

This episode is brought to you by Rupa Health, Cozy Earth, and Magnesium Breakthrough. 

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As a whole, autoimmune disease affects over 80 million Americans and five percent of the population in Western countries. They include type 1 diabetes, lupus, rheumatoid arthritis, multiple sclerosis, colitis, Crohn’s disease, and dozens of others. While your body is designed to fight off harmful things like infections, toxins, allergens, or a stress response, with autoimmune issues the body directs a hostile attack on its own joints, brain, skin, and more.

In this episode, Dr. Hyman speaks with Dr. Cynthia Li and Dr. Terry Wahls about their personal stories of working through autoimmunity and how it led them to help others using Functional Medicine. They also dive into the underlying triggers of inflammation such as stress, hidden infections, food allergies or sensitivities, toxic exposure, genetic predisposition, nutrient deficiencies, and leaky gut.

This episode is brought to you by Rupa Health, Mitopure, and Fatty15.

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In our recent Health Bites episodes, we’ve delved into the research on how our dietary choices and lifestyle impact our hormones and sexual health. From disruption caused by our sugar-heavy diets to the stressors of modern life and invisible threats of environmental toxins, our hormones often bear the brunt of our daily decisions. The good news is that there are many things we can do to bring our hormones and sexual health back in balance. 

Today, I'm delighted to bring back a standout Health Bites episode, which offers a brief overview of our sexual health series along with actionable strategies to enhance your sexual health, starting now.

In this episode, I discuss:

• The biggest killer of sex drive (2:32)
• How sugar messes up our hormones (3:12)
• The link between insulin resistance, hormones, and sexual dysfunction (5:00)
• How dietary fat plays a crucial role in our sex hormones (6:40)
• Environmental toxins as a hormone disruptor and driver of sexual dysfunction (7:30)
• Strategies to activate your sex drive (9:23)
• Peptides for optimizing sexual function in men and women (11:13)

This episode is brought to you by Rupa University and Momentous.

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There’s been a lot of recent discussion around fasting, and for good reason. But one thing that often slips through the cracks is the differences between men and women, and why women need to take a specific approach to fasting that honors their hormones. You may have heard the recent buzz around fasting and a controversial headline associating it with cardiovascular death (which was not peer-reviewed, by the way). So today, I’m resharing this popular episode with holistic health expert Dr. Mindy Pelz to shed light on what we really know about the safety of fasting, and the dos and don’ts, particularly for women.

We discuss:

• Will time-restricted eating kill you? Deciphering recent headlines
• Two major issues happening for women: Understanding hormone cycles and an evolutionary mismatch 
• Mindy’s expert approach to managing hormones through fasting 
• Three rules for successfully reintroducing foods 
• Who should avoid fasting?
• Tips for women over 40 that aren’t being talked about 
• The best way to get a handle on hormone testing

Fasting can be an incredibly healing practice, but it’s got to be done the right way—especially for women! Learn how to fast while supporting hormonal balance, and so much more, in this episode with Dr. Mindy Pelz. 

This episode is brought to you by LMNT, BIOptimizers, Thrive Market, and Happy Egg.

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There’s a foundational piece of Functional Medicine that surprises many conventional health practitioners: it’s that the health of our gut impacts every other part of the body—even the brain. With 60% of our immune system residing in our gut, it is the first place to look for an imbalance when treating illness.

In today’s episode, I talk with Dr. Elizabeth Boham and Dr. Raja Dhir about all of the insults to our gut and how to recover gut health using Functional Medicine principles.

This episode is brought to you by Rupa Health, ButcherBox, and AG1.

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Are you, or someone you know, thinking about starting a family now or in the near future? Typically, the focus on reproductive health falls on the woman, and it begins after conception has already occurred, with minimal emphasis on diet and nutrition beyond prenatal vitamins. 

However, the pre-conception window is a foundational time for both partners to take charge of their hormonal, metabolic, and overall health to ensure the healthiest sperm and egg possible for a healthy pregnancy and, most importantly, a healthy baby. 

In today's episode, we're discussing the essential steps both men and women can take to foster a nurturing environment for conception. We'll delve into lab tests and tools to support hormone and reproductive wellness, the challenges and insults of our modern-day lifestyles, and how we can use Functional Medicine to take a proactive approach by embracing diet, supplements, and exercise to prime couples for a successful pregnancy while safeguarding against developmental conditions like autism and ADHD that are doubling, or even tripling from one generation to the next. 

Whether you're just starting to think about having kids or already on your pregnancy path, this conversation is for you. 

In this episode I discuss: 

• The importance of the preconception window (3:15)(5:05)
• How epigenetics impact the preconception window (3:58)(6:01)
• How parent’s diet and lifestyle imprint their children’s epigenome (5:03)(6:59)
• Limitations of Conventional Medicine during the preconception window (9:30)(11:26)
• The Functional Medicine approach to preparing to conceive (12:12)
• Breakdown of essential nutrients and biomarkers to ensure a healthy pregnancy (15:27)
• Sex hormone and bonus lab tests (21:00)
• Optimizing blood sugar and cardiometabolic health before and during pregnancy (22:40)
• Foods to eat and foods to avoid while gearing up for pregnancy (23:44)
• Eat your foods in the correct order (protein and fat first, then carbs (36:28)
• Tips for reducing exposure to endocrine-disrupting chemicals (38:14)
• The power of exercise, stress, and sleep for a healthy pregnancy (47:24)
• Supplement recommendations for men and women for the preconception window (51:35)

This episode is brought to you by Rupa Health and AG1.

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There are several different schools of thought behind obesity and metabolic dysfunction, for example, the energy balance model or “calories-in, calories-out” perspective that many people have felt fooled by. While calories certainly are one piece, there is much more to the puzzle of weight management and metabolic health, like hormonal cascades and oxidative stress.

My guest today is Dr. Robert Lustig, an author and neuroendocrinologist with expertise in metabolism, obesity, and nutrition. He has dedicated his retirement from clinical medicine to help fix the food supply in any way he can, to reduce human suffering, and to promote a collective vision of metabolic health: protect the liver, feed the gut, support the brain. 

In this episode we discuss:

• Is a calorie really just a calorie? (7:24)
• The surprising truth: All models of energy intake are a little right and a little wrong (9:20)
• Proven methods for reducing insulin to support weight loss (29:39)
• What are obesogens and how are they hijacking our metabolic health? (32:00)
• Reactive oxygen species and aging (and how to reduce them) (38:05)
• Why glucose and insulin monitoring are powerful levers for metabolic health (42:15)
• Summing up the facts and our beliefs around calories and weight (47:00)
• The cellular impact of oxidative stress and chronic stress (54:00)
• Monch Monch: a new fiber solution for absorbing simple sugars and preventing glucose spikes as well as increasing satiety and boosting microbial diversity (1:02:20)
• Food addiction in adults and children and addressing the root cause (1:10:45)
• What actions can we take based on scientific advances to make our lives better? (1:24:15)
• Why any food that feeds the gut, protects the liver, and supports the brain is a healthy food (1:33:35)
• Perfact and how to use it to understand what is metabolically healthy at your exact grocery store (1:40:20)

This episode is brought to you by Rupa Health, Pendulum, ARMRA Colostrum, and Wonderfeel. 

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Poor metabolic health is the largest underlying cause of early death worldwide, making it the canary in the coal mine for not just type 2 diabetes, but a multitude of illnesses such as Alzheimer’s, heart disease, cancer, obesity, and even some cases of infertility and depression. Sadly, many people are walking around without even knowing they need to address their metabolic health or have any idea how to do that.

In today’s episode, I talk with Dr. William Li, Dr. Casey Means, and Dr. Richard Johnson about why metabolic health is important and ways that we can start improving it immediately at home.

This episode is brought to you by Mitopure, Cozy Earth, and AG1.

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An estimated 85% of women experience symptoms of menopause that vary from hot flashes to weight gain, brain fog, low mood, sex drive, chronic fatigue, and more. Recognizing menopause as a gradual, uniquely personal transition rather than an abrupt change is crucial. This insight can help empower women to take proactive, supportive measures early on, ensuring a smoother journey through this natural phase of life.

Today, Dr. Cindy Geyer from the UltraWellness Center joins me as we unravel the Functional Medicine perspective and approach to menopause. Our conversation highlights the crucial role of lab testing in uncovering the root causes of symptoms, paving the way for tailored nutrition and lifestyle interventions. Moreover, we critically examine the limitations of traditional medical approaches and discuss the nuances of hormone replacement therapy, the different forms, and who may benefit the most from this treatment.

Dr. Cindy Geyer received her Bachelor of Science and her Doctor of Medicine degrees, with honors, from the Ohio State University. She completed residency in internal medicine at Strong Memorial Hospital in Rochester, N.Y. and is triple board certified in internal medicine, integrative medicine, and lifestyle medicine. She joined The Ultrawellness Center in 2021 after practicing and serving as the medical director at Canyon Ranch for 23 years.

This episode is brought to you by AG1 and FOND.

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In this episode we discuss:

• How the Nurse’s Health Study caused backlash about hormone replacement therapy (3:35) 
• The issues with how menopause is treated in our society today (6:35) 
• Symptoms of menopause and their root causes (8:20) 
• The conventional medicine approach to menopause (17:57) 
• The functional medicine approach to menopause (19:38) 
• Lab testing (24:00) 
• The importance of the Estrobolome and gut microbiome testing (27:11) 
• The role of insulin, sleep, and stress (31:49) 
• Dr Cindy Geyer’s patient case study (34:21) 
• Bioidentical hormones explained (41:52) 
• The nuances of hormone replacement therapy (47:21) 
• Addressing low libido (51:00) 

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Food has the power to change everything, from our health to family dynamics, the environment, and so much more. And it all starts with one bite. Today I’m thrilled to sit down with a good friend and an inspiring food activist and entrepreneur, Kimbal Musk. Kimbal is co-founder of the seasonal and thoughtfully sourced restaurant The Kitchen, co-founder of the non-profit Big Green, and a crusader for real food.

How we choose to eat and prepare our food has implications for more than just our bodies. My conversation with Kimbal is sure to inspire you to leverage the power of real food in your own family, community, and beyond.

In this episode, we discuss (audio version):

• Kimbal’s surprising journey from the tech industry to becoming a food activist (8:30)
• How 9/11 forever changed Kimbal’s relationship with cooking (16:00)
• The experiences that inspired Kimbal to open a restaurant (25:47)
• Kimbal’s determination to provide healthy food with local sourcing (26:34)
• Food as the secret weapon for fighting the loneliness epidemic (33:50)
• How he started building a community of farmers from the ground up (37:35)
• The skyrocketing rates of childhood obesity and his work with Big Green (42:33)
• Kimbal’s life-changing accident and his revelation (44:00)
• How kids are impacted when they’re taught about growing and preparing food (52:20)
• Creating a family connection container through mealtimes and home cooking (58:00)

This episode is brought to you by Rupa Health, Butcher Box, Pique, and Open.

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The trio of alcohol, caffeine, and sugar are often the centerpiece of social engagements and times of emotional distress. While consuming them from time to time may be okay, overindulging in them can be a recipe for a disaster, leading to inflammation, insulin resistance, disrupted sleep, and more.

In today’s episode, I talk with Dr. Elizabeth Boham, Dr. Todd LePine, and Dr. Robert Lustig about how the foods we love can often have negative consequences when overconsumed.

This episode is brought to you by Rupa Health, AG1, and Essentia.

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It's easy to overlook the connection between what we eat and how we feel, but in a country where more than 1 in 5 adults are battling mental illness, suicide is on the rise, especially in children, and drug overdoses are at an all-time high, we need to stop and ask why? Why are we witnessing such unprecedented rates of mental illness? The answer lies not only in our modern-day, high-paced, stressful environment but at the end of our forks. 

In this episode of my Health Bites series, I discuss why our brains are so broken, the root causes driving neuroinflammation, and how this drives disconnection between our prefrontal cortex (the adult in the room) and amygdala (our reactive, child-like brain), causing our anxiety and emotions to take over. We’ll also discuss the research clearly showing how our toxic SAD is a key driver of our mental health crisis and how you can eat (and supplement) your way out of many mental health issues. 

This episode is brought to you by Cozy Earth and Happy Egg.

Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.

Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

In this episode I discuss (audio version):

• The state of the impact of our Standard American Diet on mental health (2:20)
• Why are we dealing with unprecedented rates of mental illness? (4:46)
• Top inflammatory foods and factors that are setting our brains on fire (6:34)
• What is metabolic health? (9:34)
• The impact of metabolic dysfunction on our brains, mood, and overall health (14:04)
• How is UPF driving poor metabolic health? (16:22)
• The link between leaky gut and leaky brain (21:47)
• How inflammation impacts the brain (23:33)
• Research on the link between junk food and mental Illness (28:01)
• The link between junk food consumption, violence, and aggression (32:38)
• The link between UPF, social functioning, and ADHD (36:58)
• Practical steps to fix your brain (39:36)

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JJ Virgin is a triple Board certified nutrition expert, Fitness Hall of Famer, and four-time New York Times bestselling author. With over three decades of experience in the field, she has become a trusted authority in nutrition, weight loss, and wellness. She is the author of four New York Times bestsellers: The Virgin Diet, The Virgin Diet Cookbook, JJ Virgin’s Sugar Impact Diet, and JJ Virgin’s Sugar Impact Diet Cookbook. 

This episode is brought to you by Rupa Health, BiOptimizers, Thrive Market, and Momentous.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10%.

Head over to thrivemarket.com/Hyman today to receive 30% off your first order and a free gift up to $60.

Head over to livemomentous.com/mark for 20% off creatine, collagen, and all of their best-in-class products.

In this episode we discuss (audio version / Apple Subscriber version):

• The shocking percentage of muscle, strength, and power we lose every year (12:58 / 11:21)
• How the science and perspective of weight training have evolved (Spoiler: it’s not just for gym rats anymore) (15:55 / 14:36)
• What is the difference between strength, power, and hypertrophy? (18:00 / 16:22)
• My personal experience overcoming chronic pain through resistance training (19:35 / 17:58)
• The Protein Leverage Hypothesis (This is why you overeat food when you undereat protein!) (25:20 / 23:41)
• The most important way to start your day (36:26 / 32:28)
• JJ’s tips for creating “metabolic spanx” and taking advantage of this “sugar sponge” (43:10 / 39:12)
• Why we should stop using scales as our only parameter of body composition and what do do instead (56:11 / 52:13)
• How your nighttime routine impacts your body composition (1:09:13 / 1:05:15)

Learn more at jjvirgin.com.

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our latest Dr. Hyman+ Functional Medicine Deep Dive on inflammatory bowel disease with Dr. Dawn Beaulieu.

Follow Dr. Beaulieu on Instagram @drdawnbeaulieu.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

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Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at [email protected] with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast only includes Dr. Hyman+ in audio content.

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The foods many of us eat every day, like breads and grains, may have an effect on our health in ways we may not even be aware of. From inflammation to a leaky gut, insulin resistance, and even autoimmune conditions, gluten often plays a role in degrading our health, as do modern farming practices that douse grains with harmful pesticides.

In today’s episode, I talk with Maggie Ward and Dr. Terry Wahls about the connection between gluten, leaky gut, and autoimmune conditions.

This episode is brought to you by Rupa University, AG1, and FOND.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

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A decrease in libido or difficulty in achieving or maintaining an erection during sex are tell-tale signs of erectile dysfunction, and they can be uncomfortable to address. Sure, aging and performance anxiety are part of the story, but believe it or not, erectile dysfunction is not just about sexual health. It’s often the first clue of bigger health issues.

In this episode of my Health Bites series, I explore the root causes of erectile dysfunction, delving into the limitations of conventional medicine, the little blue pill, and how we can utilize the power of Functional Medicine by making changes to our diet, lifestyle, and even trying things like supplements, peptides, and hormone therapy. 

This episode is brought to you by Mitopure and Rupa Health.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10.

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In this episode, I discuss (audio version / Apple Subscriber version):

• The prevalence of erectile dysfunction (4:34 / 2:04)
• The root cause of low testosterone (9:38 / 7:08)
• The conventional medicine approach to treating erectile dysfunction (11:51 / 9:21)
• How do Viagra and ED drugs work? (16:34 / 14:04)
• The Functional Medicine approach to treating erectile dysfunction: diagnostic testing (18:58 / 16:28)
• Root causes of sexual dysfunction (29:42 / 27:12)
• Diet, lifestyle, and supplements to improve sexual dysfunction (42:22 / 39:52)

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Kelly LeVeque is a holistic nutritionist, celebrity health coach, the best-selling author of Body Love and Body Love Every Day, and most importantly, mom of three little boys. Kelly LeVeque is passionate about the science of human nutrition and is always guided by a practical and optimistic approach to wellness. Kelly helps clients improve their health, achieve goals, and develop sustainable habits to live a healthy and balanced life. Kelly is a regular contributor to numerous health, wellness, and lifestyle publications.

This episode is brought to you by Rupa Health, LMNT, Thrive Market, and ButcherBox.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today.

Head over to thrivemarket.com/Hyman today to receive 30% off your first order and a free gift up to $60.

ButcherBox is giving new members FREE ground beef for LIFE with their first order. Visit butcherbox.com/farmacy and use code FARMACY.

In this episode we discuss (audio version / Apple Subscriber version):

• Why we’re seeing an increasing incidence of infertility (4:45 / 3:02)
• Environmental toxins and ways to limit exposure (10:04 / 8:21)
• Men’s health and fertility (13:02 / 11:19)
• Optimizing sperm quality at every age (16:32 / 14:49)
• Selecting a prenatal with methylfolate, not folic acid (21:41 / 19:58)
• Preparing for pregnancy (25:20 / 21:22)
• Epigenetics and pregnancy (30:45 / 26:48)
• Assessing prenatal supplement quality (39:19 / 35:22)
• Nutrition status and postpartum depletion and depression (45:22 / 41:25)
• Focusing on what you have control over (49:23 / 45:26)

Learn more at BeWellByKelly.com.

Head to WeNatal.com/DrHyman to receive a FREE 30-day supply of their Omega DHA+ fish oil ($34.95 value) with purchase of any subscription.

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask A Doctor Anything episode with Dr. Elizabeth Boham.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

- Exclusive monthly Functional Medicine Deep Dives

- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at [email protected] with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast does not include access to the Dr. Hyman+ site and only includes Dr. Hyman+ in audio content. 

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Muscle mass is essential for maintaining a healthy weight, but it is also a key factor in metabolic health, reducing the risk of chronic disease, and in improving our healthspan and longevity. While muscle requires consuming the right amount of protein for your body, weight-bearing exercises, as a part of strength training routine, are also an important ingredient for building skeletal muscle.

In today’s episode, I talk with Dr. Gabrielle Lyon, Dr. Sara Gottfried, and Dr. Todd LePine about the many benefits of muscle and why strength training is non-negotiable.

This episode is brought to you by Rupa University, AG1, and Sweetgreen.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

We could use more Sweetgreens in the world. So check out your nearest Sweetgreen or go to Sweetgreen.com to learn more.

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Today, we're zooming in on a groundbreaking study that comes from Stanford University and was recently published in JAMA Network Open. The researchers put a vegan diet head-to-head with an omnivorous diet in twenty-two pairs of identical twins. The buzz around this study has been immense, sparking conversations everywhere—from social media to professional circles. Adding to the excitement, this research forms the basis of a new Netflix documentary called "You Are What You Eat: A Twin Experiment." 

In this episode of my Health Bites series, I discuss the many conflicts of interest, funding sources, and hidden agendas that were not fully disclosed but could have had a major hand in clouding the study's conclusions and real-world applications. We’ll also get into the Netflix docuseries itself—what they got right vs. what they got wrong, as well as the Functional Medicine approach to diet and how we can feed our bodies to create health while taking care of the planet in a healthy, sustainable, and ethical way.

This episode is brought to you by Rupa Health, Momentous, and Happy Egg.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Head over to livemomentous.com/mark for 20% off creatine, collagen, and all of their best-in-class products.

Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

In this episode, I discuss (audio version / Apple Subscriber version):

• Why nutrition research is so confusing (7:26 / 5:36)
• Overview of the Stanford study design and findings (11:57 / 10:07)
• Issues with the study design (27:10 / 24:10)
• Conflicts of interest and ethical considerations with this study (38:19 / 35:19)
• Other research on vegan diets (44:44 / 41:44)
• What the Netflix documentary got right and wrong (1:00:23 / 57:23)
• How to eat for your health and the environment (1:08:43 / 1:05:43)

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Dr. Sharon Hausman-Cohen is the Chief Medical Officer and co-founder of IntellxxDNA and has been in the field of integrative medicine for over 25 years. She is the co-author of many publications and a textbook chapter on using genomics to improve outcomes in cognitive decline and autism.

This episode is brought to you by Rupa Health, Fatty15, BiOptimizers, and ARMRA.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.

Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10% and receive free gifts with your purchase.

Save 15% on your first order of ARMRA Colostrum and unlock the power of 400+ functional nutrients. Just visit TryARMRA.com/Mark or use code MARK.

In this episode we discuss (audio version / Apple Subscriber version):

• What are genes and what do they do? (6:37 / 4:33)
• Genetic predisposition does not mean predestined (9:22 / 7:18)
• The difference between genetics vs genomics (13:10 / 11:06)
• Polygenic risk scoring for chronic disease (18:18 / 16:14)
• Dementia risk and treatment (33:59 / 29:24)
• Mental and cognitive health issues in children (46:00 / 41:25)
• The similarities between Autism and Alzheimer’s patients (49:49 / 45:14)
• My genomic test results, specifically related to detoxification and osteoporosis (52:21 / 47:45)
• Genetic vs genomic testing (1:06:29 / 1:01:54)

Learn more at IntellxxDNA.com.

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Your gut microbiome is your inner garden—the more good bugs you have in it, the more likely it is to flourish. Our gut bacteria regulate many bodily functions, from creating vitamins to controlling our immune system, brain function, and, of course, our metabolism and weight. They are critical to our long-term health. But even if you’re eating the right things, you may need outside assistance to maintain plentiful and diverse gut bacteria.

In today’s episode, I talk with Dr. Steven Gundry, Dr. Mark Pimentel, Dr. Uma Naidoo, and Dr. Zach Bush about the importance of the microbiome and why it should be considered in any disease treatment plan.

This episode is brought to you by Rupa Health, Cozy Earth, AG1, and Essentia.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

Receive an extra $100 off your mattress purchase! Go to myessentia.com/drmarkhyman and use code HYMAN at checkout to get this great deal.

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Heart disease is the world's leading cause of death. For years, the diet-heart hypothesis, which centers on high cholesterol as the primary culprit, has dominated the medical discourse. But now, we're beginning to appreciate the complexity and nuance of how the outer workings of our environment influence the inner workings of our physiology and risk for heart disease.

In today’s episode of a new series I’m calling Know Your Numbers, I deep dive into the Functional Medicine approach to assessing cardiovascular risk and why this is key to preventing and, in some cases, reversing cardiovascular disease.

You can test your cardiovascular risk with Function Health, a company I co-founded. It has been a lifelong dream for me. Function is the first-ever membership that includes 100+ lab tests and personalized insights from globally renowned doctors based on your results. Join Function at FunctionHealth.com.

This episode is brought to you by AG1, Sweetgreen, and OPEN.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs + a FREE Welcome Kit with your first order.

We could use more Sweetgreens in the world. So check out your nearest Sweetgreen or go to Sweetgreen.com to learn more.

Take your meditation practice further and start your FREE 30-day trial of Open by visiting withopen.com/MARK today.

Here are more details from the episode (audio version / Apple Subscriber version):

• Prevalence of cardiovascular disease and heart attacks (9:38 / 8:08)
• Why conventional medicine misses the mark in assessing and treating cardiovascular disease risk and “high” cholesterol (10:50 / 9:20)
• The testing you should be getting to assess cardiovascular risk (28:23 / 26:53)
• The major root causes of heart disease (46:38 / 44:10)
• Cholesterol: What is it and how is it related to heart disease? (47:20 / 44:52)
• Insulin resistance and heart disease (55:09 / 52:50)
• Total cholesterol, triglycerides, HDL, LDL cholesterol, and other relevant biomarkers (58:12 / 55:44)
• Root causes of suboptimal biomarkers (1:28:05 / 1:25:37)
• Additional diagnostic testing (1:31:04 / 1:28:36)
• Diet, lifestyle, and supplements for reducing cardiovascular risk (1:37:30 / 1:35:02)

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Dr. Eric Topol is the Founder and Director of the Scripps Research Translational Institute, Professor of Molecular Medicine, and Executive Vice-President of Scripps Research. He has published over 1,200 peer-reviewed articles with more than 330,000 citations, was elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine. His principal scientific focus has been on individualized medicine using genomic, digital, and AI tools.

This episode is brought to you by Rupa Health, Pendulum, Thrive Market, and Fatty15.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Pendulum is offering listeners 20% off their first month’s subscription of Akkermansia for gut health. Visit PendulumLife.com and use code HYMAN.

Head over to thrivemarket.com/Hyman today to receive 30% off your first order and a free gift up to $60.

Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.

In this episode we discuss (audio version / Apple Subscriber version):

• The first phase of AI’s application in medicine (7:19 / 5:40)
• How medicine will incorporate AI over the next few years (9:59 / 8:19)
• Retinal imaging (16:45 / 15:05)
• Expert-informed AI (20:02 / 18:23)
• The impending and biggest shake-up in the history of medicine (22:18 / 20:38)
• How AI can improve issues of medical error (26:08 / 24:29)
• Using AI to personalize medicine and prevent disease (33:01 / 29:11)
• The obesity crisis and toxic food environment (41:04 / 37:14)
• How AI can help restore the patient-doctor relationship (46:53 / 43:03)
• Using AI as a guide for medical self care (50:34 / 46:44)
• Reimagining research in the era of AI-enabled medicine (56:58 / 53:07)

Dr. Topol’s Substack, Ground Truths.

Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again

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We are getting sicker every day from cheap, addictive junk food. The food industry approaches food as “engineering projects,” with the end goal of creating “heavy users”—a disturbing internal term used by food manufacturers that helps them make as much money as possible at the expense of public health. It’s time we take a look at the intentional manipulation of our taste buds and the politics that support these practices.

In today’s episode, I talk with Michael Moss, Dhru Purohit, Calley Means, and Nina Teicholz about the formula to get you addicted to junk food and the money spent to influence you to buy more.

This episode is brought to you by Rupa University, AG1, ButcherBox, and Seed.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

ButcherBox is giving new members FREE ground beef for LIFE with their first order. Visit butcherbox.com/farmacy and use code FARMACY.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

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Recently, a study made headlines linking red meat consumption to an increased risk for type 2 diabetes. It’s no secret that navigating the realm of nutrition has become a challenge for the general public. 

That’s why, on today’s Health Bites episode, we’re diving deep into the findings from this study, “Red meat intake and risk of type 2 diabetes in a prospective cohort study of United States females and males,” published in The American Journal of Clinical Nutrition. I unpack the study’s design flaws, inaccuracies, and where the researchers got it straight up wrong. 

This episode is brought to you by Rupa University, Happy Egg, and Mitopure.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10.

In this episode, I discuss (audio version / Apple Subscriber version):

• What we can and cannot learn from observational research (3:42 / 1:56)
• “Red meat intake and risk of type 2 diabetes in a prospective cohort study of United States females and males” study design and findings (9:01 / 7:15)
• Issues with the study design and why it does not prove that red meat causes type 2 diabetes (20:01 / 16:23)
• What have other studies found? (39:20 / 35:42)
• The root cause of type 2 diabetes (44:02 / 40:24)
• Strategies to address type 2 diabetes (44:29 / 40:51)

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Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions. 

This episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15.

For a limited time, you can save up to $600 on a Sunlighten infrared sauna. Just go to sunlighten.com/mark-hyman and mention my name.

Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.

Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10% and get a free gift with purchase.

Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.

In this episode we discuss (audio version / Apple Subscriber version):

• The hallmarks of aging (9:01 / 7:10)
• What causes the hallmarks of aging? (15:40 / 13:49)
• Dr. Barzilai’s research on centenarians (23:16 / 21:25)
• Why living to 100+ years is good for the economy (24:54 / 23:03)
• What enables someone to live to 100 years old? (29:30 / 25:20)
• Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)
• The connection between HDL cholesterol and longevity (43:36 / 39:26)
• Dr. Barzilai’s research on Metformin (56:23 / 52:13)
• How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)
• Dr. Barzilai’s personal longevity (1:42:05 / 1:37:55)

Learn more about the Longevity Genes Project and the TAME Trial. 

Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our latest Dr. Hyman+ Functional Medicine Deep Dive on gut health with Dr. Pedi Mirdamadi.

Learn more about Dr. Twyman at oasishealthandmedicine.com/ and follow him on Instagram @drpedinaturalhealth/.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

- Exclusive monthly Functional Medicine Deep Dives

- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at [email protected] with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast only includes Dr. Hyman+ in audio content.

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In today's episode, I’m sharing key takeaways and powerful moments from episodes that aired last month, January 2024. Links to each episode can be found in the show notes, so you can easily go back to any episode you might have missed.

Here are more details from the episode (audio version / Apple Subscriber version):

• How mental health issues are tied to diet with Dr. Uma Naidoo (2:23 / 0:36)
• The importance of protein (6:24 / 4:37)
• The brain-microbiome connection with Dr. Steven Gundry (8:34 / 6:48)
• Magnesium deficiency (11:42 / 9:56)
• Probiotics and fermented foods with Raja Dhir (14:11 / 12:25)
• Optimizing our immune system to fight Covid and other infections (20:15 / 17:10)
• Childhood nutrition with Robert F. Kennedy Jr. (23:32 / 20:28)
• How our hormones make us hungry (27:19 / 24:15)
• How the food industry hurts our health (31:13 / 28:09)

This episode is brought to you by Rupa Health, AG1, and Momentous.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

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Head over to livemomentous.com/mark for 20% off creatine, collagen, and all of their best-in-class products.

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Do you feel fatigued, lethargic, and sluggish, especially when you wake up in the morning? Do you have poor-quality, cracked nails? Are you cold all the time? Do you have dry skin, coarse hair, or hair loss? Are you depressed? Are you constipated? Do you have muscle and joint pains? 

If you answered yes to any of the above, you may be one of the 38 million Americans with low thyroid function. 

In today’s episode of a new series I’m calling Know Your Numbers, I dive deep into thyroid dysfunction. I discuss why millions of people suffer with undetected thyroid issues, how conventional medicine misses the mark in measuring thyroid levels, how Functional Medicine treats hypothyroidism and hyperthyroidism, and much more.

You can test your magnesium levels with Function Health, a company I co-founded. It has been a lifelong dream for me. Function is the first-ever membership that includes 100+ lab tests and personalized insights from globally renowned doctors based on your results. Join Function at FunctionHealth.com.

This episode is brought to you by Mitopure and AG1.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use the code DRHYMAN10.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs plus a FREE Welcome Kit with your first order.

Here are more details from the episode (audio version / Apple Subscriber version):

• Symptoms and prevalence of hypothyroidism (4:29 / 2:29)
• Autoimmune thyroid disorders: Hashimoto’s thyroiditis and hyperthyroidism (7:37 /  5:37)
• What does a healthy, hypo- and hyper- thyroid gland do? (8:55 / 6:55)
• Risk factors for thyroid problems (15:58 / 13:58)
• Gluten and other drivers of thyroid problems (17:40 / 15:40)
• How conventional medicine misses the mark with thyroid testing and treatment (22:15 / 20:15)
• The Functional Medicine approach to thyroid testing and treatment (25:21 / 23:21) 
• Addressing poor thyroid function using diet, lifestyle, and supplements diet (28:59 / 26:59)

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Calley Means is the founder of TrueMed, a company that enables tax-free spending on food and exercise. He is also the co-author with his sister, Dr. Casey Means, of Good Energy: The Surprising Connection Between Metabolism and Limitless Health, which is coming out later this year and is now available for pre-order.

Earlier in his career, Calley was a consultant for food and pharma companies and is now exposing practices they use to weaponize our institutions of trust. In the past year, he's met with 50 members of Congress and presidential candidates advocating policies to combat the corruption of the pharma and food industries. He is a Graduate of Stanford and Harvard Business School. 

This episode is brought to you by Rupa Health, Fatty15, Thrive Market, and Happy Egg.

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Shopping for better eggs shouldn’t be confusing. Look for the yellow carton at your local grocery store or visit happyegg.com/farmacy to find Happy Egg near you.

In this episode we discuss (audio version / Apple Subscriber version):

• How the pharmaceutical industry is the largest funder of government, think tank organizations, academic research, and media outlets (7:44 / 5:59)
• Why America is getting sicker, fatter, more depressed, and more infertile (11:19 / 9:34)
• Corruption in industry and government that’s harming our health (20:02 / 18:18)
• Ozempic as a treatment for obesity in kids (29:00 / 25:10)
• How obesity is harming our national security (35:03 / 31:13)
• Taking control of your own health (39:20 / 35:29)
• Banning food and pharmaceutical ads on television (44:25 / 40:34)
• Is Ozempic bad for mental health? (56:10 / 52:19)
• How government subsidizes and recommends ultra-processed food (58:25 / 54:34)
• The thing that can counteract the influence of money (1:15:08 / 1:11:17)

Get a copy of Good Energy. Learn about Calley’s work at Trumed.

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask A Doctor Anything episode with Dr. Elizabeth Boham.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

- Exclusive monthly Functional Medicine Deep Dives

- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at [email protected] with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast does not include access to the Dr. Hyman+ site and only includes Dr. Hyman+ in audio content. 

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In today’s episode, I talk with Dhru Purohit, Dr. Elizabeth Boham, and Dr. Dale Bredesen about the numerous things we can do to protect our brains and even reverse cognitive decline.

Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.

Dr. Elizabeth Boham is a physician and nutritionist who practices Functional Medicine at The UltraWellness Center in Lenox, MA. Through her practice and lecturing she has helped thousands of people achieve their goals of optimum health and wellness. She witnesses the power of nutrition every day in her practice and is committed to training other physicians to utilize nutrition in healing.

Dr. Dale Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease and the author of the New York Times bestsellers The End of Alzheimer's, The End of Alzheimer's Program, and his latest book The First Survivors of Alzheimer's: How Patients Recovered Life and Hope in Their Own Words.

This episode is brought to you by Rupa University, AG1, Momentous, and Sweetgreen.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs plus a FREE Welcome Kit with your first order.

Head over to livemomentous.com/mark for 20% off creatine, collagen, and all of their best-in-class products.

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Our hormones coordinate many different functions in our body and control everything from our metabolism to our sexual function, circadian rhythms, and mood. These chemical messengers also play a big role when it comes to our appetites.

In today’s episode of my series I’m calling Health Bites, I am talking about two lesser-known hormones, leptin and ghrelin, which you may not have heard of before but that have a direct impact on our body and health. 

This episode is brought to you by Mitopure, Rupa Health, and Seed.

Support essential mitochondrial health and save 30% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN30.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com today.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

In this episode, I discuss (audio version / Apple Subscriber version):

• Why are so many people overweight? (3:29 / 1:36)
• What do leptin and ghrelin regulate in our bodies? (4:20 / 2:27)
• What happens when your leptin and ghrelin levels are out of whack? (6:27 / 4:35)
• Strategies to keep your leptin and ghrelin levels balanced and healthy (12:02 / 8:46)

Mentioned in this episode

The Fat Resistance Diet by Dr. Leo Galland

Force of Nature

FOOD: What the Heck Should I Eat?

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Robert F. Kennedy, Jr. is an independent candidate for President of the United States. He is the founder of the Waterkeeper Alliance—the world’s largest clean water advocacy group—and served as its longtime chairman and attorney. He founded the Children’s Health Defense, where he served as chairman and chief litigation counsel in its campaign to address childhood chronic disease and toxic exposures. He was also on the team that prosecuted and won the case against Monsanto for glyphosate's role in causing cancer.

As President, he promises to restore the middle class, unravel corporate capture, end the chronic disease epidemic, improve the quality of the water we drink and the air we breathe, heal the divide, fix our public education system, take care of our veterans, support the trades, make homes affordable again, support regenerative farming, among other key priorities.

This episode is brought to you by Rupa Health, Cozy Earth, Bioptimizers, and Fatty15.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.

This month only you can get a FREE bottle of Bioptimizers Magnesium Breakthrough. Just go to magbreakthrough.com/hymanfree and enter coupon code hyman10.

Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.

In this episode we discuss (audio version / Apple Subscriber version):

• The state of health in America (5:41 / 4:01)
• One of the main reasons RFK Jr. is running for president (8:39 / 6:59)
• The beginning of the autism epidemic (12:38 / 10:58)
• Addressing harms caused by ultra-processed food (15:03 / 13:23)
• Eliminating corporate culture in government agencies (33:05 / 28:41)
• America’s disproportionate deaths from COVID-19 (42:10 / 37:46)
• How America’s health status is affecting our national security (44:34 / 40:10)
• Solving the mental health crisis (47:41 / 43:17)
• Food and drug TV marketing (56:14 / 51:49)
• Bobby’s thinking about fitness for himself and America (1:03:39 / 59:14)

Enter for a chance to hike in LA with Bobby and me here.

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In today’s episode, I talk with Ken Cook, Dr. Elizabeth Boham, and Maggie Ward about toxin exposures all around us and how to remove toxins from our bodies.

Ken Cook is the president and co-founder of the Environmental Working Group (EWG). He is widely recognized as one of the environmental community’s most prominent and influential critics of industrial agriculture and the nation’s broken approach to protecting families and children from toxic substances. Under Cook’s leadership, the EWG has pioneered the use of digital technologies to empower American families with easy-to-use, science-driven tools to help reduce their exposure to potentially harmful ingredients in food, drinking water, cosmetics, and other household products. Capitol Hill’s closely read newspaper The Hill regularly lists Cook in its annual roster of Washington’s top lobbyists, writing that Cook’s “influence spans the country” and calling EWG “the tip of the green movement’s spear.”

Dr. Elizabeth Boham is a physician and nutritionist who practices Functional Medicine at The UltraWellness Center in Lenox, MA. Through her practice and lecturing she has helped thousands of people achieve their goals of optimum health and wellness. She witnesses the power of nutrition every day in her practice and is committed to training other physicians to utilize nutrition in healing.

Maggie Ward, MS, RD, LDN, is the Nutrition Director at The UltraWellness Center. Maggie holds a master’s degree in Nutrition from Bastyr University which focuses on using whole foods for holistic Nutrition Therapy. In addition, she completed her requirements to become a registered dietitian at Westchester Medical Center in NY. Prior to joining The UltraWellness Center team in 2008, Maggie worked at The Brooklyn Hospital Center in New York providing nutrition counseling to children and families dealing with HIV. She also taught at the Jewish Community Center in Manhattan and other sites throughout New York City, teaching nutritionally focused cooking classes for children and adults. Much of her focus is on food allergies, digestive disorders, inflammatory conditions, pediatrics, and sports nutrition.

This episode is brought to you by Rupa Health and ButcherBox.

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ButcherBox is giving new members FREE ground beef for LIFE with their first order. Visit butcherbox.com/farmacy and use code FARMACY.

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In today’s episode of my series I’m calling Health Bites, I am tackling a topic that has left an indelible mark on the world: the COVID-19 pandemic. As we navigate through new variants and climbing cases, it's crucial to unravel the reasons why so many Americans got so sick and died during the pandemic. We dig into the questions of why we as a nation were so susceptible to COVID-19’s deadly effects. I also explore why and how Functional Medicine steps in where conventional approaches stumble.

This episode is brought to you by AG1, Rupa Health, and Seed.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

In this episode, I discuss (audio version / Apple Subscriber version):

• Why the U.S. had some of the worst COVID-19 outcomes (7:07 / 5:24)
• The conventional medicine approach to the COVID-19 pandemic (25:46 / 22:41)
• My take on COVID vaccines (28:30 / 25:25)
• Optimizing our immune system to prevent serious infection and disease (39:09 / 36:04)
• Preventing and recovering from illness using diet and lifestyle (47:19 / 44:14)
• Supplements to support your immune system during cold and flu season (57:00 / 53:55)
• Strategies for COVID infection and exposure (59:34 / 56:29)
• Long-COVID (1:02:51 / 59:46)

Connect with Dr. Mark Hyman on Twitter, Instagram, Facebook, and YouTube

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Raja Dhir is co-founder and co-CEO of Seed Health, a microbiome science company pioneering innovations in probiotics and living medicines to impact human and planetary health. With unique expertise in translating scientific research for product innovation, Raja guides the development of Seed Health’s platform to enable rapid, efficient advancement of microbial research from discovery to market. He also leads the company’s academic collaborations, working with institutions like MIT, Harvard University, Stanford University, California Institute of Technology (Caltech), and the National Institute of Health (NIH) to drive innovation across the fields of microbiology, genetics, immunology, and ecology. He co-chairs Seed’s Scientific Board –an interdisciplinary group of leading scientists, researchers, and clinicians–with Dr. Jacques Ravel.

Raja also oversees Seed's environmental endeavors under SeedLabs and directs LUCA Biologics, a venture targeting the vaginal microbiome for unmet needs in urogenital and reproductive health.

This episode is brought to you by Rupa Health, Fatty15, ARMRA, and Sweetgreen.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.

Save 15% on your first order of ARMRA Colostrum and unlock the power of 400+ functional nutrients. Just visit TryARMRA.com/Mark or use code MARK.

We could use more Sweetgreens in the world. So check out your nearest Sweetgreen or go to Sweetgreen.com to learn more.

In this episode we discuss (audio version / Apple Subscriber version):

• The central role the gut plays in our overall health (4:50 / 3:04)
• How the makeup of our gut microbiome comes to be (11:25 / 9:40)
• Why fiber is critical to reaping the benefits of akkermansia (12:59 / 11:13)
• The explosion of research on the gut microbiome (20:22 / 18:44)
• Microbiome testing (29:09 / 25:15)
• What are probiotics and should you take them? (33:41 / 29:47)
• Selecting a probiotic (42:45 / 38:49)
• Prebiotics, synbiotics and postbiotics (53:19 / 49:25)
• How antibiotics affect the gut microbiome (58:38 / 54:44)
• The future of microbiome data (1:14:34 / 1:10:40)

Learn more about Raja’s work at Seed.

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In today’s episode, I talk with Shawn Stevenson, Dr. Todd LePine, Dr. Andrew Huberman, and Dr. Cindy Geyer about the value of sleep and the basics of sleep hygiene.

Shawn Stevenson is the author of the international bestselling book Sleep Smarter and creator of The Model Health Show, featured as the #1 health podcast in the U.S. with millions of downloads each year. A graduate of the University of Missouri–St. Louis, Shawn studied business, biology, and nutritional science, and went on to found Advanced Integrative Health Alliance, a company that provides wellness services for individuals and organizations worldwide.

Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body.

Dr. Andrew Huberman is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award in 2017, which is given to the scientist making the largest discoveries in the study of vision. His lab’s most recent work focuses on the influence of vision and respiration on human performance and brain states such as fear and courage. Work from the Huberman Laboratory at Stanford University School of Medicine has been published in top journals including Nature, Science, and Cell and has been featured in TIME, BBC, Scientific American, Discover, and other top media outlets.

Dr. Cindy Geyer received her Bachelor of Science and her Doctor of Medicine degrees, with honors, from the Ohio State University. She completed residency in internal medicine at Strong Memorial Hospital in Rochester, N.Y. and is triple board certified in internal medicine, integrative medicine, and lifestyle medicine. She joined The UltraWellness Center in 2021 after practicing and serving as the medical director at Canyon Ranch for 23 years.

This episode is brought to you by Rupa Health, AG1, and Sweetgreen.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

Check out your nearest Sweetgreen or go to Sweetgreen.com to learn more.

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Magnesium is a critical mineral that is responsible for more than 600 enzyme reactions in the body, yet most people are not getting enough of it. Magnesium is critical for your cells to make energy, for many different chemical pumps to work, to stabilize membranes, and to help muscles relax. Essentially, anything that is tight, irritable, crampy, or stiff—whether it is a body part or even a mood—can be a sign of low levels of magnesium, and magnesium deficiency has even been linked to inflammation in the body and higher CRP levels. 

In today’s episode of a new series I’m calling Know Your Numbers, I dive deep into magnesium. I discuss why millions of people suffer with undetected magnesium deficiency, how conventional medicine misses the mark in measuring magnesium levels, how Functional Medicine treats magnesium deficiency, and much more.

You can test your magnesium levels with Function Health, a company I co-founded. It has been a lifelong dream for me. Function is the first-ever membership that includes 100+ lab tests and personalized insights from globally renowned doctors based on your results. Join Function at FunctionHealth.com.

This episode is brought to you by AG1 and Open.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs + a Welcome Kit with your first order.

Take your meditation practice further and start your FREE 30-day trial of Open by visiting WithOpen.com/Mark today.

Here are more details from the episode (audio version / Apple Subscriber version):

• Symptoms of magnesium deficiency (5:23 / 3:25)
• Why is magnesium deficiency a problem? (6:19 / 4:21)
• Testing magnesium levels (7:27 / 5:29)
• How magnesium works in the body (8:45 / 6:47)
• Why magnesium deficiency is so prevalent (11:46 / 9:48)
• The Functional Medicine approach to measuring magnesium levels (16:14 / 14:16)
• Root causes of and conditions related to magnesium deficiency (17:48 / 15:50)
• Addressing magnesium deficiency (23:27 / 21:29)

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Dr. Steven Gundry is one of the world’s top cardiothoracic surgeons and a pioneer in nutrition. He hosts a top-rated health show, The Dr. Gundry Podcast, is the founder and Director of The International Heart and Lung Institute Center for Restorative Medicine, and is the founder of Gundry MD, a line of wellness products and supplements. He is the author of New York Times bestsellers The Plant Paradox, The Plant Paradox Cookbook, The Plant Paradox Quick & Easy, and The Longevity Paradox, along with national bestsellers The Plant Paradox Family Cookbook, The Energy Paradox, Dr. Gundry’s Diet Evolution, and Unlocking the Keto Code, and has had more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He just released his latest book, Gut Check: Unleash the Power of Your Microbiome to Reverse Disease and Transform Your Mental, Physical, and Emotional Health.

This episode is brought to you by Rupa Health, Mitopure, Beekeeper’s Naturals, and Momentous.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Support essential mitochondrial health and save 30% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN30.

Listeners can save 20% off sitewide on Beekeeper’s Naturals. Just go to beekeepersnaturals.com/hyman and use code HYMAN.

Head over to livemomentous.com/mark for 20% off creatine, collagen, and all of their best-in-class products.

In this episode we discuss (audio version / Apple Subscriber version):

• How Dr. Gundry and I discovered the significance of the gut microbiome (8:05 / 5:29)
• Hallmarks of a healthy microbiome (15:21 / 12:45)
• Feeding the microbiome (17:11 / 14:35)
• Maintaining a healthy, impenetrable gut wall through mitochondrial uncoupling (23:03 / 20:27)
• The role of polyphenols in the gut microbiome (32:50 / 27:55)
• Research on the microbiomes of centenarians and their ability to produce Urolithin A (48:23 / 43:28)
• The mood, brain, gut connection (1:02:32 / 57:37)
• Cancer and the gut microbiome (1:05:42 / 1:00:47)
• Dr. Gundry’s tips for gut health (1:18:31 / 1:13:36)